UBE2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.14290626
2protein localization to kinetochore (GO:0034501)5.61810575
3mitotic sister chromatid segregation (GO:0000070)5.56493041
4kinetochore organization (GO:0051383)5.49454425
5regulation of spindle organization (GO:0090224)5.42013236
6metaphase plate congression (GO:0051310)5.34078743
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.31138113
8kinetochore assembly (GO:0051382)5.22562540
9protein localization to chromosome, centromeric region (GO:0071459)5.22347474
10DNA ligation (GO:0006266)5.13036546
11sister chromatid segregation (GO:0000819)5.00977592
12establishment of chromosome localization (GO:0051303)4.95941989
13CENP-A containing nucleosome assembly (GO:0034080)4.83094033
14attachment of spindle microtubules to kinetochore (GO:0008608)4.79619128
15regulation of mitotic spindle organization (GO:0060236)4.72006331
16chromatin remodeling at centromere (GO:0031055)4.65551695
17mitotic chromosome condensation (GO:0007076)4.64991675
18establishment of integrated proviral latency (GO:0075713)4.55222321
19positive regulation of chromosome segregation (GO:0051984)4.32274872
20mitotic nuclear envelope disassembly (GO:0007077)4.31428611
21DNA replication-independent nucleosome organization (GO:0034724)4.23869950
22DNA replication-independent nucleosome assembly (GO:0006336)4.23869950
23ventricular cardiac muscle cell development (GO:0055015)4.16427331
24* spindle checkpoint (GO:0031577)4.15947108
25histone exchange (GO:0043486)3.99537136
26DNA strand elongation involved in DNA replication (GO:0006271)3.98333431
27* regulation of chromosome segregation (GO:0051983)3.97922632
28DNA replication checkpoint (GO:0000076)3.97594935
29membrane disassembly (GO:0030397)3.97322157
30nuclear envelope disassembly (GO:0051081)3.97322157
31protein localization to chromosome (GO:0034502)3.89468131
32* negative regulation of chromosome segregation (GO:0051985)3.87554501
33DNA replication initiation (GO:0006270)3.85913143
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.85030456
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.85030456
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.85030456
37* spindle assembly checkpoint (GO:0071173)3.83328624
38* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.82047795
39* negative regulation of sister chromatid segregation (GO:0033046)3.82047795
40* negative regulation of mitotic sister chromatid separation (GO:2000816)3.82047795
41* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.82047795
42maturation of SSU-rRNA (GO:0030490)3.80391655
43DNA strand elongation (GO:0022616)3.79163493
44formation of translation preinitiation complex (GO:0001731)3.78694449
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77245550
46chromosome segregation (GO:0007059)3.76859514
47telomere maintenance via semi-conservative replication (GO:0032201)3.76719292
48* mitotic spindle checkpoint (GO:0071174)3.75659199
49establishment of viral latency (GO:0019043)3.74421435
50* mitotic spindle assembly checkpoint (GO:0007094)3.73962187
51meiotic chromosome segregation (GO:0045132)3.72432322
52* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.72034843
53* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.70392293
54DNA unwinding involved in DNA replication (GO:0006268)3.70323869
55nucleobase biosynthetic process (GO:0046112)3.68701966
56* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.62978992
57purine nucleobase biosynthetic process (GO:0009113)3.61173277
58DNA packaging (GO:0006323)3.57673328
59* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54470227
60* regulation of mitotic sister chromatid separation (GO:0010965)3.53923817
61* regulation of mitotic sister chromatid segregation (GO:0033047)3.53923817
62* regulation of sister chromatid segregation (GO:0033045)3.53923817
63ribosomal small subunit assembly (GO:0000028)3.52354690
64* negative regulation of ligase activity (GO:0051352)3.48953170
65* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48953170
66mitotic recombination (GO:0006312)3.45487981
67DNA replication-dependent nucleosome organization (GO:0034723)3.43720351
68DNA replication-dependent nucleosome assembly (GO:0006335)3.43720351
69microtubule depolymerization (GO:0007019)3.43274384
70telomere maintenance via recombination (GO:0000722)3.43232668
71histone-serine phosphorylation (GO:0035404)3.41498974
72regulation of centrosome cycle (GO:0046605)3.40100916
73DNA deamination (GO:0045006)3.34702219
74ribosomal large subunit biogenesis (GO:0042273)3.33861159
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32887650
76chaperone-mediated protein transport (GO:0072321)3.31243106
77ribosome assembly (GO:0042255)3.27862305
78* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27723447
79viral transcription (GO:0019083)3.27419118
80spliceosomal snRNP assembly (GO:0000387)3.26961465
81translational termination (GO:0006415)3.24905893
82ribosome biogenesis (GO:0042254)3.24040530
83telomere maintenance via telomere lengthening (GO:0010833)3.23317423
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.23023643
85regulation of telomere maintenance via telomerase (GO:0032210)3.22124680
86ribonucleoprotein complex biogenesis (GO:0022613)3.21123737
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20854208
88nuclear pore organization (GO:0006999)3.19939082
89ATP-dependent chromatin remodeling (GO:0043044)3.18305871
90ribosomal small subunit biogenesis (GO:0042274)3.17930090
91chromosome condensation (GO:0030261)3.17561530
92chromatin assembly or disassembly (GO:0006333)3.17135455
93regulation of mitochondrial translation (GO:0070129)3.16210110
94* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15576367
95nuclear envelope organization (GO:0006998)3.15481955
96translational initiation (GO:0006413)3.13117764
97* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11926824
98proteasome assembly (GO:0043248)3.10911830
99* regulation of ubiquitin-protein transferase activity (GO:0051438)3.08617908
100* mitotic cell cycle (GO:0000278)3.07809982
101protein complex localization (GO:0031503)3.07405334
102* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05896488
103DNA topological change (GO:0006265)3.05153243
104* negative regulation of mitosis (GO:0045839)3.04295131
105rRNA processing (GO:0006364)3.03475289
106protein K6-linked ubiquitination (GO:0085020)3.02420610
107* negative regulation of cell division (GO:0051782)3.02007032
108spindle assembly involved in mitosis (GO:0090307)3.01175303
109regulation of nuclear cell cycle DNA replication (GO:0033262)2.99830487
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.99678316
111spliceosomal complex assembly (GO:0000245)2.98940100
112mitotic nuclear division (GO:0007067)2.98458391
113* negative regulation of nuclear division (GO:0051784)2.98407803
114* negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.98388655
115mitotic cytokinesis (GO:0000281)2.98332141
116translational elongation (GO:0006414)2.97631478
117* positive regulation of ligase activity (GO:0051351)2.96521392
118* regulation of ligase activity (GO:0051340)2.95693906
119rRNA modification (GO:0000154)2.94993102
120rRNA metabolic process (GO:0016072)2.94033729
121regulation of sister chromatid cohesion (GO:0007063)2.93649856
122regulation of spindle checkpoint (GO:0090231)2.93482054
123mitotic G2/M transition checkpoint (GO:0044818)2.92489622
124mitotic spindle organization (GO:0007052)2.87922789
125microtubule polymerization or depolymerization (GO:0031109)2.84787155
126cell cycle G1/S phase transition (GO:0044843)2.83969588
127G1/S transition of mitotic cell cycle (GO:0000082)2.83969588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.54026059
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.87871349
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.31073503
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.24320910
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.11825540
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55299394
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42942225
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98442907
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93687861
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81849632
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.77249618
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77117193
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75047149
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73458272
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69385099
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.64214220
17AR_21909140_ChIP-Seq_LNCAP_Human2.56453490
18* XRN2_22483619_ChIP-Seq_HELA_Human2.35252684
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34005634
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28951126
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27970565
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20552380
23VDR_23849224_ChIP-Seq_CD4+_Human2.08321866
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02808392
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00139405
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.96048873
27DCP1A_22483619_ChIP-Seq_HELA_Human1.95402960
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94490918
29* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92015146
30FOXP3_21729870_ChIP-Seq_TREG_Human1.87424766
31TTF2_22483619_ChIP-Seq_HELA_Human1.81400861
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81255991
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78779118
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77812989
35GABP_19822575_ChIP-Seq_HepG2_Human1.76962354
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73048587
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69972922
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67696951
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64609669
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63812445
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.63491262
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63010468
43CIITA_25753668_ChIP-Seq_RAJI_Human1.61048063
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52084773
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.51365374
46* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50449818
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48743355
48ELK1_19687146_ChIP-ChIP_HELA_Human1.48390696
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44754087
50KDM5A_27292631_Chip-Seq_BREAST_Human1.43635044
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40118134
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38339358
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37554812
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.36064263
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33645957
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33069454
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31998158
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31975807
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30063002
60MYC_22102868_ChIP-Seq_BL_Human1.25668740
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25148216
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22454208
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.21167245
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19289191
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18087415
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17172225
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16266675
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11273986
69* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07427875
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06883062
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06172863
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04922287
73* SOX2_16153702_ChIP-ChIP_HESCs_Human1.01709537
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.01655321
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.00994584
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00421195
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98871546
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98040914
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97990642
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97955222
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96080912
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95143973
83TFEB_21752829_ChIP-Seq_HELA_Human0.94586472
84MYC_18940864_ChIP-ChIP_HL60_Human0.92989219
85RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91076655
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89577904
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89405439
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88963071
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88260612
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86346174
91VDR_21846776_ChIP-Seq_THP-1_Human0.84369425
92ZNF263_19887448_ChIP-Seq_K562_Human0.83778855
93SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83360041
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82768515
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.80990147
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80907101
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79833752
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79828406
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79505665
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79414696
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79387825
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78545322
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78282402
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77661684
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76990864
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76624310
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75167079
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74223630
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.71183719
110SPI1_23547873_ChIP-Seq_NB4_Human0.70970642
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.70885647
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.70885647
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69821825
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69748870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.52553879
2MP0003111_abnormal_nucleus_morphology5.57101382
3MP0004957_abnormal_blastocyst_morpholog4.74047189
4MP0010094_abnormal_chromosome_stability4.71447714
5MP0003077_abnormal_cell_cycle4.63262443
6MP0008057_abnormal_DNA_replication3.42307591
7MP0008058_abnormal_DNA_repair3.09352119
8MP0008007_abnormal_cellular_replicative3.01205578
9MP0008932_abnormal_embryonic_tissue2.88602297
10MP0003123_paternal_imprinting2.54081267
11MP0001730_embryonic_growth_arrest2.47245004
12MP0000350_abnormal_cell_proliferation2.27280847
13MP0003718_maternal_effect2.16178920
14MP0010030_abnormal_orbit_morphology2.07909383
15MP0009697_abnormal_copulation1.94799015
16MP0003786_premature_aging1.94614978
17MP0002396_abnormal_hematopoietic_system1.92438737
18MP0005380_embryogenesis_phenotype1.87183771
19MP0001672_abnormal_embryogenesis/_devel1.87183771
20MP0001697_abnormal_embryo_size1.84117163
21MP0010307_abnormal_tumor_latency1.83764726
22MP0009379_abnormal_foot_pigmentation1.66443938
23MP0008877_abnormal_DNA_methylation1.66110576
24MP0002080_prenatal_lethality1.65860302
25MP0002085_abnormal_embryonic_tissue1.64612908
26MP0003984_embryonic_growth_retardation1.63030672
27MP0002088_abnormal_embryonic_growth/wei1.59063211
28MP0000490_abnormal_crypts_of1.54477571
29MP0000313_abnormal_cell_death1.47466870
30MP0002086_abnormal_extraembryonic_tissu1.44424320
31MP0000566_synostosis1.41452054
32MP0001346_abnormal_lacrimal_gland1.39302694
33MP0003136_yellow_coat_color1.38921864
34MP0003567_abnormal_fetal_cardiomyocyte1.38188403
35MP0010352_gastrointestinal_tract_polyps1.35257970
36MP0002084_abnormal_developmental_patter1.34691835
37MP0002019_abnormal_tumor_incidence1.33057854
38MP0003941_abnormal_skin_development1.30690151
39MP0004808_abnormal_hematopoietic_stem1.28803038
40MP0003315_abnormal_perineum_morphology1.24769150
41MP0002697_abnormal_eye_size1.24440502
42MP0004197_abnormal_fetal_growth/weight/1.23932490
43MP0009333_abnormal_splenocyte_physiolog1.22129598
44MP0008789_abnormal_olfactory_epithelium1.20650031
45MP0006035_abnormal_mitochondrial_morpho1.18176388
46MP0005076_abnormal_cell_differentiation1.17270856
47MP0001545_abnormal_hematopoietic_system1.16953739
48MP0005397_hematopoietic_system_phenotyp1.16953739
49MP0003121_genomic_imprinting1.16058916
50MP0006292_abnormal_olfactory_placode1.14527173
51MP0002210_abnormal_sex_determination1.13867702
52MP0001293_anophthalmia1.10521816
53MP0001529_abnormal_vocalization1.07864091
54MP0009053_abnormal_anal_canal1.05881434
55MP0001145_abnormal_male_reproductive1.04376402
56MP0002234_abnormal_pharynx_morphology1.02916490
57MP0004147_increased_porphyrin_level1.02475801
58MP0003656_abnormal_erythrocyte_physiolo1.02066012
59MP0003119_abnormal_digestive_system0.97636757
60MP0003890_abnormal_embryonic-extraembry0.97114894
61MP0002233_abnormal_nose_morphology0.96271492
62MP0009672_abnormal_birth_weight0.94552664
63MP0001929_abnormal_gametogenesis0.93988278
64MP0002132_abnormal_respiratory_system0.93806380
65MP0000537_abnormal_urethra_morphology0.92694949
66MP0003937_abnormal_limbs/digits/tail_de0.90631433
67MP0004133_heterotaxia0.89102510
68MP0000703_abnormal_thymus_morphology0.89012488
69MP0000653_abnormal_sex_gland0.88347370
70MP0000372_irregular_coat_pigmentation0.87685927
71MP0005499_abnormal_olfactory_system0.86754751
72MP0005394_taste/olfaction_phenotype0.86754751
73MP0000579_abnormal_nail_morphology0.85967616
74MP0002111_abnormal_tail_morphology0.85214819
75MP0005389_reproductive_system_phenotype0.83004598
76MP0002102_abnormal_ear_morphology0.82133870
77MP0003755_abnormal_palate_morphology0.81897402
78MP0006054_spinal_hemorrhage0.79785086
79MP0002722_abnormal_immune_system0.79381567
80MP0000762_abnormal_tongue_morphology0.79098614
81MP0002653_abnormal_ependyma_morphology0.77708555
82MP0003938_abnormal_ear_development0.77552101
83MP0001119_abnormal_female_reproductive0.76617164
84MP0003186_abnormal_redox_activity0.76463114
85MP0000647_abnormal_sebaceous_gland0.76443838
86MP0001919_abnormal_reproductive_system0.73917553
87MP0009250_abnormal_appendicular_skeleto0.73764585
88MP0000858_altered_metastatic_potential0.73200006
89MP0002398_abnormal_bone_marrow0.73169113
90MP0005257_abnormal_intraocular_pressure0.71581116
91MP0002160_abnormal_reproductive_system0.70864640
92MP0005384_cellular_phenotype0.70764877
93MP0003861_abnormal_nervous_system0.70580587
94MP0001286_abnormal_eye_development0.70459928
95MP0009278_abnormal_bone_marrow0.69479803
96MP0003699_abnormal_female_reproductive0.69320458
97MP0005621_abnormal_cell_physiology0.69175619
98MP0002938_white_spotting0.68965052
99MP0000358_abnormal_cell_content/0.68903306
100MP0002177_abnormal_outer_ear0.67459598
101MP0000689_abnormal_spleen_morphology0.67454960
102MP0002877_abnormal_melanocyte_morpholog0.67431927
103MP0009703_decreased_birth_body0.67039794
104MP0003221_abnormal_cardiomyocyte_apopto0.66633558
105MP0000750_abnormal_muscle_regeneration0.66497619
106MP0002161_abnormal_fertility/fecundity0.66311808
107MP0002796_impaired_skin_barrier0.65232246
108MP0003806_abnormal_nucleotide_metabolis0.64923506
109MP0008260_abnormal_autophagy0.64107148
110MP0001881_abnormal_mammary_gland0.63883825
111MP0002163_abnormal_gland_morphology0.61375933
112MP0005023_abnormal_wound_healing0.60192372
113MP0002932_abnormal_joint_morphology0.60088965
114MP0003698_abnormal_male_reproductive0.59645959
115MP0000428_abnormal_craniofacial_morphol0.59245590
116MP0003385_abnormal_body_wall0.58744652
117MP0003942_abnormal_urinary_system0.58359456
118MP0002092_abnormal_eye_morphology0.58099138
119MP0002429_abnormal_blood_cell0.57682385
120MP0003115_abnormal_respiratory_system0.56614213
121MP0006072_abnormal_retinal_apoptosis0.56301906
122MP0001727_abnormal_embryo_implantation0.55822701
123MP0000049_abnormal_middle_ear0.55266342
124MP0000432_abnormal_head_morphology0.54995506
125MP0000627_abnormal_mammary_gland0.54807391
126MP0005501_abnormal_skin_physiology0.54394916
127MP0006036_abnormal_mitochondrial_physio0.54318475
128MP0000733_abnormal_muscle_development0.53976986
129MP0003935_abnormal_craniofacial_develop0.53397972
130MP0005197_abnormal_uvea_morphology0.52573407
131MP0002127_abnormal_cardiovascular_syste0.52318471
132MP0005395_other_phenotype0.52221262
133MP0003763_abnormal_thymus_physiology0.52181008
134MP0004264_abnormal_extraembryonic_tissu0.52162666

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.60052072
2Breast hypoplasia (HP:0003187)4.43275123
3Reticulocytopenia (HP:0001896)4.25705943
4Chromsome breakage (HP:0040012)4.10996825
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.06002027
6Carpal bone hypoplasia (HP:0001498)3.97819197
7Patellar aplasia (HP:0006443)3.96836462
8Aplasia/Hypoplasia of the patella (HP:0006498)3.76002217
9Abnormality of cells of the erythroid lineage (HP:0012130)3.67274257
10Oral leukoplakia (HP:0002745)3.58409341
11Abnormal number of erythroid precursors (HP:0012131)3.55695272
12Meckel diverticulum (HP:0002245)3.51902154
13Impulsivity (HP:0100710)3.41793475
14Abnormality of the ileum (HP:0001549)3.35924797
15Duodenal stenosis (HP:0100867)3.27965818
16Small intestinal stenosis (HP:0012848)3.27965818
17Acute necrotizing encephalopathy (HP:0006965)3.26344953
18Abnormality of the preputium (HP:0100587)3.26106091
19Rough bone trabeculation (HP:0100670)3.23711519
20Abnormal mitochondria in muscle tissue (HP:0008316)3.19621639
21Abnormal lung lobation (HP:0002101)3.16039526
22Abnormality of chromosome stability (HP:0003220)3.13234655
23Cortical dysplasia (HP:0002539)3.10069864
24Absent radius (HP:0003974)3.09105031
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.08546865
26Selective tooth agenesis (HP:0001592)2.95893602
27Colon cancer (HP:0003003)2.94852600
28Acute encephalopathy (HP:0006846)2.94190248
29Abnormality of the anterior horn cell (HP:0006802)2.94054372
30Degeneration of anterior horn cells (HP:0002398)2.94054372
31Aplasia involving forearm bones (HP:0009822)2.87533651
32Absent forearm bone (HP:0003953)2.87533651
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.83925285
34Mitochondrial inheritance (HP:0001427)2.80662954
35Absent thumb (HP:0009777)2.80596709
36Myelodysplasia (HP:0002863)2.75793299
37Macrocytic anemia (HP:0001972)2.75631607
38Cerebral hypomyelination (HP:0006808)2.72766531
39Medulloblastoma (HP:0002885)2.70852380
40Hypoplastic pelvis (HP:0008839)2.69603952
41Abnormality of the duodenum (HP:0002246)2.67938812
42Increased CSF lactate (HP:0002490)2.64310807
43Microvesicular hepatic steatosis (HP:0001414)2.58001265
44Hepatocellular necrosis (HP:0001404)2.56290100
45Sloping forehead (HP:0000340)2.55436018
46Trismus (HP:0000211)2.53551077
47Aplastic anemia (HP:0001915)2.52496457
48Bone marrow hypocellularity (HP:0005528)2.49973001
49Pallor (HP:0000980)2.49039976
50Increased nuchal translucency (HP:0010880)2.48880479
51Broad distal phalanx of finger (HP:0009836)2.48541000
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47286047
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47286047
54Horseshoe kidney (HP:0000085)2.46526396
55Nephroblastoma (Wilms tumor) (HP:0002667)2.45863148
56Reduced antithrombin III activity (HP:0001976)2.44638787
57Duplicated collecting system (HP:0000081)2.43755732
58Abnormal number of incisors (HP:0011064)2.42953723
59Type I transferrin isoform profile (HP:0003642)2.42911465
60Progressive macrocephaly (HP:0004481)2.42325155
61Multiple enchondromatosis (HP:0005701)2.40802505
62Increased hepatocellular lipid droplets (HP:0006565)2.39189329
63Neoplasm of the pancreas (HP:0002894)2.37946294
64Abnormality of the labia minora (HP:0012880)2.37849955
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36817502
66Triphalangeal thumb (HP:0001199)2.35920621
67Premature graying of hair (HP:0002216)2.34264308
68Microretrognathia (HP:0000308)2.33878577
69Abnormal trabecular bone morphology (HP:0100671)2.33584926
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.32656949
71Premature ovarian failure (HP:0008209)2.31957040
72Abnormal umbilical cord blood vessels (HP:0011403)2.30391409
73Single umbilical artery (HP:0001195)2.30391409
74Abnormality of the fetal cardiovascular system (HP:0010948)2.30391409
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30274863
76Supernumerary spleens (HP:0009799)2.29433466
77Ectopic kidney (HP:0000086)2.29040807
78Atresia of the external auditory canal (HP:0000413)2.28797172
79Tracheoesophageal fistula (HP:0002575)2.27588814
80Hepatic necrosis (HP:0002605)2.26565489
81Embryonal renal neoplasm (HP:0011794)2.26560851
82Cleft eyelid (HP:0000625)2.26464503
83Ureteral duplication (HP:0000073)2.26286231
84Ependymoma (HP:0002888)2.24374318
85Short middle phalanx of the 5th finger (HP:0004220)2.23303697
86Increased serum pyruvate (HP:0003542)2.21412579
8711 pairs of ribs (HP:0000878)2.20127319
88Cerebral edema (HP:0002181)2.19795212
89Abnormality of glycolysis (HP:0004366)2.18656329
90Rhabdomyosarcoma (HP:0002859)2.17741373
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.17108539
92Secondary amenorrhea (HP:0000869)2.14302361
93Septo-optic dysplasia (HP:0100842)2.13793753
94Cellular immunodeficiency (HP:0005374)2.12105353
95Lipid accumulation in hepatocytes (HP:0006561)2.11409815
96Progressive muscle weakness (HP:0003323)2.10683238
97Abnormality of reticulocytes (HP:0004312)2.09232706
98Increased serum lactate (HP:0002151)2.07991996
99Absent septum pellucidum (HP:0001331)2.07968005
100Short thumb (HP:0009778)2.06060210
101Abnormality of the renal collecting system (HP:0004742)2.05289308
102Duplication of thumb phalanx (HP:0009942)2.04401588
103Cafe-au-lait spot (HP:0000957)2.03839349
104Abnormality of the septum pellucidum (HP:0007375)2.01613707
105Pancytopenia (HP:0001876)1.97572681
106Proximal placement of thumb (HP:0009623)1.96541814
107Abnormality of the umbilical cord (HP:0010881)1.95835930
108Neoplasm of the colon (HP:0100273)1.95311195
109Exercise intolerance (HP:0003546)1.94727189
110Facial hemangioma (HP:0000329)1.90477182
111Abnormality of the carotid arteries (HP:0005344)1.90058145
112Abnormality of the proximal phalanges of the hand (HP:0009834)1.88668912
113Agnosia (HP:0010524)1.88411789
114Volvulus (HP:0002580)1.87462389
115Squamous cell carcinoma (HP:0002860)1.85264846
116Deviation of the thumb (HP:0009603)1.83613107
117Abnormality of abdominal situs (HP:0011620)1.83252913
118Abdominal situs inversus (HP:0003363)1.83252913
119Lactic acidosis (HP:0003128)1.82464550
120Choanal atresia (HP:0000453)1.81288723
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79283466
122Abnormal protein N-linked glycosylation (HP:0012347)1.79283466
123Abnormal protein glycosylation (HP:0012346)1.79283466
124Abnormal glycosylation (HP:0012345)1.79283466
125Sparse eyelashes (HP:0000653)1.78905619
126Hypoplasia of the radius (HP:0002984)1.78672868
127Glossoptosis (HP:0000162)1.75926289
128Prominent nose (HP:0000448)1.75889003
129Irregular epiphyses (HP:0010582)1.75187738
130Embryonal neoplasm (HP:0002898)1.74700588
131Oligodactyly (HP:0012165)1.74586468
132Increased intramyocellular lipid droplets (HP:0012240)1.74397786
133Renal Fanconi syndrome (HP:0001994)1.73532121
134Overlapping toe (HP:0001845)1.73199049
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72253970
136Absent epiphyses (HP:0010577)1.72253970
137Aplasia/hypoplasia of the humerus (HP:0006507)1.72075496
138Facial cleft (HP:0002006)1.71295649
139Abnormality of the calcaneus (HP:0008364)1.71279533
140Small epiphyses (HP:0010585)1.70911711
141Basal cell carcinoma (HP:0002671)1.70705238
142Calcaneovalgus deformity (HP:0001848)1.69675988
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.69473476
144Clubbing of toes (HP:0100760)1.69196935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB17.34263169
2WEE14.67939076
3VRK23.48789043
4NEK23.42645818
5BRSK23.16875166
6CDC73.13656991
7EIF2AK12.96118880
8TTK2.89741688
9BRSK12.86512694
10PLK12.42661142
11PLK42.32636336
12NEK12.31742688
13SRPK12.17264616
14NME22.05206913
15AURKB2.00053922
16PLK31.87242778
17STK161.79735282
18AURKA1.78810176
19TESK21.70783198
20STK101.67279497
21VRK11.61047728
22CCNB11.60282693
23MAP3K81.51756732
24TSSK61.51594312
25CDK71.50590256
26CHEK21.50563590
27DYRK31.49993005
28MKNK11.46886955
29STK41.42418711
30RPS6KA41.37629015
31EIF2AK31.35580112
32TLK11.34498697
33ACVR1B1.31918273
34MELK1.30226014
35ATR1.28027129
36MKNK21.27741463
37ZAK1.27586820
38TAF11.20367888
39CDK41.18346408
40PBK1.16884202
41EPHA21.12966326
42CDK121.07825670
43CHEK11.07452061
44RPS6KB21.02954836
45EIF2AK20.99266177
46PAK40.96484120
47BRAF0.93182540
48SMG10.88715272
49TRIM280.84982962
50MST40.84313008
51PAK10.77887417
52NUAK10.77837478
53PASK0.77744019
54CDK20.70902800
55STK30.69913767
56ATM0.69432781
57MST1R0.66501454
58MAP3K100.66334859
59CDK10.64045791
60CDK80.64045719
61PDK20.64029679
62MARK30.63052919
63CDK60.58999195
64PIM10.58421815
65STK38L0.57909638
66KDR0.57241768
67CSNK2A10.56998119
68UHMK10.55996011
69MAP3K110.53131236
70TESK10.51319960
71PRKCI0.51061242
72BCKDK0.50207490
73PIM20.49935391
74CSNK2A20.47901719
75AKT20.45663816
76BRD40.45444134
77AKT30.42666481
78ERBB40.41625252
79TNIK0.41257408
80LATS20.41130005
81ARAF0.40769313
82RPS6KA50.39507739
83PNCK0.39378870
84CLK10.39262776
85TAOK20.38525091
86CDK90.37611170
87MAP2K30.37114527
88EEF2K0.37082487
89MET0.37020116
90DYRK20.35285671
91MAPK110.34706334
92ALK0.34246308
93TGFBR10.34023988
94NME10.33984671
95MAPKAPK20.31575864
96CDK140.31518156
97LRRK20.31293130
98FLT30.28320013
99ABL20.27042798
100CDK190.25767674
101CSNK1G30.24403343
102EPHB20.23297402
103SCYL20.22417348
104MAP4K10.22349929
105DAPK10.21949632
106WNK30.21715908
107MAPKAPK30.21342441
108CSNK1G10.20919145
109MTOR0.18511946
110CDK30.17781497
111PRKDC0.17367821
112ILK0.17138971
113CSNK1E0.16992229
114MINK10.16739724
115CDC42BPA0.14071122
116CDK11A0.14047721
117MAPK140.13510979
118RPS6KA10.13423871
119ERBB20.13313452
120CDK150.11338704
121AKT10.10373207
122GRK60.09606523
123CDK180.09526381
124LIMK10.08887879

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48775372
2Mismatch repair_Homo sapiens_hsa034303.88640741
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61599985
4Ribosome_Homo sapiens_hsa030103.54406576
5RNA polymerase_Homo sapiens_hsa030203.50665158
6Cell cycle_Homo sapiens_hsa041103.44142636
7Spliceosome_Homo sapiens_hsa030403.42645096
8RNA transport_Homo sapiens_hsa030133.30359815
9Proteasome_Homo sapiens_hsa030503.27018052
10Base excision repair_Homo sapiens_hsa034103.16344970
11Homologous recombination_Homo sapiens_hsa034403.12079547
12Nucleotide excision repair_Homo sapiens_hsa034202.73903944
13Pyrimidine metabolism_Homo sapiens_hsa002402.52547023
14Fanconi anemia pathway_Homo sapiens_hsa034602.45419816
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12168320
16Vitamin B6 metabolism_Homo sapiens_hsa007502.11110670
17One carbon pool by folate_Homo sapiens_hsa006702.07951005
18p53 signaling pathway_Homo sapiens_hsa041152.00537819
19Basal transcription factors_Homo sapiens_hsa030221.98460325
20RNA degradation_Homo sapiens_hsa030181.86856315
21Non-homologous end-joining_Homo sapiens_hsa034501.83071874
22mRNA surveillance pathway_Homo sapiens_hsa030151.76332478
23Oocyte meiosis_Homo sapiens_hsa041141.61038970
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58149600
25Purine metabolism_Homo sapiens_hsa002301.35314374
26Fatty acid elongation_Homo sapiens_hsa000621.29903497
27Alzheimers disease_Homo sapiens_hsa050101.28299271
28Systemic lupus erythematosus_Homo sapiens_hsa053221.27884751
29Epstein-Barr virus infection_Homo sapiens_hsa051691.25932986
30Pyruvate metabolism_Homo sapiens_hsa006201.16808720
31* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06802908
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03549764
33Viral carcinogenesis_Homo sapiens_hsa052030.90583860
34Pentose phosphate pathway_Homo sapiens_hsa000300.90152262
35Folate biosynthesis_Homo sapiens_hsa007900.87547621
36Herpes simplex infection_Homo sapiens_hsa051680.86468529
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85747669
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79917474
39HTLV-I infection_Homo sapiens_hsa051660.77959676
40Steroid biosynthesis_Homo sapiens_hsa001000.76950867
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.76231871
42Biosynthesis of amino acids_Homo sapiens_hsa012300.71119566
43MicroRNAs in cancer_Homo sapiens_hsa052060.71038907
44Huntingtons disease_Homo sapiens_hsa050160.68936584
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.68097399
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67286216
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62737742
48Selenocompound metabolism_Homo sapiens_hsa004500.61379286
49Small cell lung cancer_Homo sapiens_hsa052220.61208620
50Glutathione metabolism_Homo sapiens_hsa004800.58270049
51Antigen processing and presentation_Homo sapiens_hsa046120.55488177
52Hippo signaling pathway_Homo sapiens_hsa043900.54887799
53Sulfur relay system_Homo sapiens_hsa041220.54540972
54Cardiac muscle contraction_Homo sapiens_hsa042600.54522693
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53274926
56Basal cell carcinoma_Homo sapiens_hsa052170.53102062
57Propanoate metabolism_Homo sapiens_hsa006400.52048136
58Thyroid cancer_Homo sapiens_hsa052160.51774394
59Parkinsons disease_Homo sapiens_hsa050120.47547594
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46285303
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.45557928
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44695887
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44544026
64Regulation of autophagy_Homo sapiens_hsa041400.43631190
65Protein export_Homo sapiens_hsa030600.41964761
66Apoptosis_Homo sapiens_hsa042100.41782243
67TGF-beta signaling pathway_Homo sapiens_hsa043500.40632434
68Hedgehog signaling pathway_Homo sapiens_hsa043400.40216394
69Alcoholism_Homo sapiens_hsa050340.39797717
70Carbon metabolism_Homo sapiens_hsa012000.37774385
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37579713
72Sulfur metabolism_Homo sapiens_hsa009200.37100813
73Arginine and proline metabolism_Homo sapiens_hsa003300.37051590
74Fructose and mannose metabolism_Homo sapiens_hsa000510.36199859
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35975834
76Notch signaling pathway_Homo sapiens_hsa043300.34961896
77Wnt signaling pathway_Homo sapiens_hsa043100.34728416
78Legionellosis_Homo sapiens_hsa051340.34361264
79Colorectal cancer_Homo sapiens_hsa052100.32277500
80Bladder cancer_Homo sapiens_hsa052190.32113354
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31863654
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30238996
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29841476
84Hepatitis B_Homo sapiens_hsa051610.28569284
85Phenylalanine metabolism_Homo sapiens_hsa003600.23660723
86Shigellosis_Homo sapiens_hsa051310.23532921
87FoxO signaling pathway_Homo sapiens_hsa040680.23390224
88Pathways in cancer_Homo sapiens_hsa052000.23260285
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23239978
90Metabolic pathways_Homo sapiens_hsa011000.22519669
91Oxidative phosphorylation_Homo sapiens_hsa001900.22319666
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21979144
93Lysine degradation_Homo sapiens_hsa003100.21614257
94Tyrosine metabolism_Homo sapiens_hsa003500.21436312
95Primary immunodeficiency_Homo sapiens_hsa053400.21079371
96Arachidonic acid metabolism_Homo sapiens_hsa005900.19962091
97HIF-1 signaling pathway_Homo sapiens_hsa040660.19748612
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19639516
99Galactose metabolism_Homo sapiens_hsa000520.18954152
100Fatty acid metabolism_Homo sapiens_hsa012120.17378963
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.17009218
102Measles_Homo sapiens_hsa051620.16896351
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16743268
104Vitamin digestion and absorption_Homo sapiens_hsa049770.16654849
105Chronic myeloid leukemia_Homo sapiens_hsa052200.16611656
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16042987
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16024147
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15988874
109Influenza A_Homo sapiens_hsa051640.14786786
110N-Glycan biosynthesis_Homo sapiens_hsa005100.14299767
111Tight junction_Homo sapiens_hsa045300.13071456
112Adherens junction_Homo sapiens_hsa045200.13041455
113Prostate cancer_Homo sapiens_hsa052150.12769066
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.12336130
115Asthma_Homo sapiens_hsa053100.12231825
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12039563
117Hematopoietic cell lineage_Homo sapiens_hsa046400.11739205
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11636362
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11557090
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11456100
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11304221
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.11266284
123Peroxisome_Homo sapiens_hsa041460.09254387
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07898481

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