UBE2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.35142137
2proteasome assembly (GO:0043248)5.13112969
3protein neddylation (GO:0045116)4.53635654
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51850128
5DNA deamination (GO:0045006)4.40839163
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35940723
7ATP synthesis coupled proton transport (GO:0015986)4.35940723
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.33014974
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.25467313
10termination of RNA polymerase III transcription (GO:0006386)4.25467313
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12473891
12chaperone-mediated protein transport (GO:0072321)4.10209491
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.08104552
14antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.00189380
15establishment of integrated proviral latency (GO:0075713)3.99949471
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.99491050
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.98367294
18negative regulation of ligase activity (GO:0051352)3.94186262
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.94186262
20regulation of cellular amino acid metabolic process (GO:0006521)3.90107298
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.87555740
22deoxyribonucleotide biosynthetic process (GO:0009263)3.85931839
23ribosomal small subunit assembly (GO:0000028)3.84129397
24protein deneddylation (GO:0000338)3.82850309
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78798236
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78798236
27RNA capping (GO:0036260)3.78427822
287-methylguanosine RNA capping (GO:0009452)3.78427822
29cullin deneddylation (GO:0010388)3.76563289
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75537636
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75537636
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75537636
337-methylguanosine mRNA capping (GO:0006370)3.75431112
34viral transcription (GO:0019083)3.75004253
35ribosomal small subunit biogenesis (GO:0042274)3.73786422
36regulation of protein heterodimerization activity (GO:0043497)3.72419165
37translational termination (GO:0006415)3.69895072
38establishment of viral latency (GO:0019043)3.67451428
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.64852431
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.62009470
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62009470
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.60485741
43signal transduction involved in cell cycle checkpoint (GO:0072395)3.56402127
44ribosome assembly (GO:0042255)3.54487543
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50359657
46positive regulation of ligase activity (GO:0051351)3.49412386
47cotranslational protein targeting to membrane (GO:0006613)3.49233105
48maturation of SSU-rRNA (GO:0030490)3.48971122
49protein heterotetramerization (GO:0051290)3.48921587
50protein targeting to ER (GO:0045047)3.41326219
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41063974
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35973260
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.35973260
54NADH dehydrogenase complex assembly (GO:0010257)3.35973260
55respiratory electron transport chain (GO:0022904)3.35817372
56COPI coating of Golgi vesicle (GO:0048205)3.35755620
57Golgi transport vesicle coating (GO:0048200)3.35755620
58protein targeting to mitochondrion (GO:0006626)3.35202122
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.34330618
60protein localization to endoplasmic reticulum (GO:0070972)3.31925608
61rRNA modification (GO:0000154)3.31115873
62translation (GO:0006412)3.30257768
63translational elongation (GO:0006414)3.29277509
64de novo protein folding (GO:0006458)3.29264633
65establishment of protein localization to mitochondrion (GO:0072655)3.28156399
66electron transport chain (GO:0022900)3.26755533
67sequestering of actin monomers (GO:0042989)3.23775380
68protein complex biogenesis (GO:0070271)3.23244558
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22892894
70negative regulation of protein ubiquitination (GO:0031397)3.22578621
71ribosomal large subunit biogenesis (GO:0042273)3.21335263
72neutrophil activation involved in immune response (GO:0002283)3.20833148
73translational initiation (GO:0006413)3.20150961
74formation of translation preinitiation complex (GO:0001731)3.13068274
75mitotic metaphase plate congression (GO:0007080)3.11656095
76regulation of ubiquitin-protein transferase activity (GO:0051438)3.11474017
77positive regulation of actin filament depolymerization (GO:0030836)3.08896696
78* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.07372174
79DNA replication checkpoint (GO:0000076)3.05957072
80negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.05947222
81de novo posttranslational protein folding (GO:0051084)3.05096074
82viral life cycle (GO:0019058)3.04860987
83regulation of ligase activity (GO:0051340)3.04383985
84activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.03980171
85platelet dense granule organization (GO:0060155)3.03670784
86purine nucleotide salvage (GO:0032261)3.03615171
87negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.02605971
88protein localization to mitochondrion (GO:0070585)3.01029469
89cellular protein complex disassembly (GO:0043624)3.00313243
90DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.99589981
91ribonucleoprotein complex biogenesis (GO:0022613)2.99314958
92DNA strand elongation involved in DNA replication (GO:0006271)2.98615867
93mitochondrial respiratory chain complex assembly (GO:0033108)2.98587584
94nucleobase-containing small molecule interconversion (GO:0015949)2.97470147
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96669020
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95703942
97positive regulation of cell cycle arrest (GO:0071158)2.94925646
98positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93522973
99cell cycle G1/S phase transition (GO:0044843)2.92731019
100G1/S transition of mitotic cell cycle (GO:0000082)2.92731019
101regulation of cellular amine metabolic process (GO:0033238)2.92518720
102nuclear envelope reassembly (GO:0031468)2.92498849
103mitotic nuclear envelope reassembly (GO:0007084)2.92498849
104transcription-coupled nucleotide-excision repair (GO:0006283)2.91198063
105telomere maintenance via semi-conservative replication (GO:0032201)2.89756577
106negative regulation of cell cycle G1/S phase transition (GO:1902807)2.88728613
107negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.88728613
108cellular component biogenesis (GO:0044085)2.87774534
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84615278
110CENP-A containing nucleosome assembly (GO:0034080)2.84001066
111deoxyribose phosphate biosynthetic process (GO:0046385)2.83575871
1122-deoxyribonucleotide biosynthetic process (GO:0009265)2.83575871
113regulation of cell cycle arrest (GO:0071156)2.83074687
114regulation of mitochondrial translation (GO:0070129)2.82831555
115cytochrome complex assembly (GO:0017004)2.82768970
116deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81560361
117L-methionine salvage (GO:0071267)2.78829314
118L-methionine biosynthetic process (GO:0071265)2.78829314
119amino acid salvage (GO:0043102)2.78829314
120protein localization to kinetochore (GO:0034501)2.78716480
121DNA strand elongation (GO:0022616)2.78619770
122transcription from RNA polymerase I promoter (GO:0006360)2.77623126
123membrane budding (GO:0006900)2.76732902
124signal transduction in response to DNA damage (GO:0042770)2.76196118
125rRNA processing (GO:0006364)2.74541718
126transcription elongation from RNA polymerase II promoter (GO:0006368)2.73408085
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73150441
128guanosine-containing compound biosynthetic process (GO:1901070)2.72874936
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72838549
130respiratory chain complex IV assembly (GO:0008535)2.72516010
131protein localization to chromosome, centromeric region (GO:0071459)2.70309605
132AMP metabolic process (GO:0046033)2.69735612
133positive regulation of protein ubiquitination (GO:0031398)2.69476794
134chromatin remodeling at centromere (GO:0031055)2.67341139
135negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.66144554
136ventricular cardiac muscle cell development (GO:0055015)2.65980685
137negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.65012373
138heart process (GO:0003015)2.64185290
139heart contraction (GO:0060047)2.64185290
140DNA damage response, detection of DNA damage (GO:0042769)2.58641970
141regulation of spindle organization (GO:0090224)2.57309628
142fatty acid elongation (GO:0030497)2.55826478
143positive regulation of protein modification by small protein conjugation or removal (GO:1903322)2.54664258
144natural killer cell mediated cytotoxicity (GO:0042267)2.53209398
145natural killer cell mediated immunity (GO:0002228)2.53209398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59652048
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.42170939
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.04999335
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84360684
5E2F7_22180533_ChIP-Seq_HELA_Human3.73844259
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.61015286
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.55906722
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.47051423
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39462391
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39367285
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.27019919
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06437157
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97896328
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92091008
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84609555
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80302162
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76843876
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74986591
19* VDR_23849224_ChIP-Seq_CD4+_Human2.67399157
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66849493
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50910998
22DCP1A_22483619_ChIP-Seq_HELA_Human2.46719094
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.37832676
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.35847598
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29208465
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28508246
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25617731
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25409146
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25349053
30* XRN2_22483619_ChIP-Seq_HELA_Human2.14995521
31* ELK1_19687146_ChIP-ChIP_HELA_Human2.14702912
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09916682
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07640505
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.01185265
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01109221
36FOXP3_21729870_ChIP-Seq_TREG_Human1.98569574
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96843071
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96214413
39GABP_19822575_ChIP-Seq_HepG2_Human1.95099823
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93101945
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90722804
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84802108
43TTF2_22483619_ChIP-Seq_HELA_Human1.83959616
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77827242
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77098765
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.75960337
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.72141322
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65106933
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.62146429
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60950354
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.58650438
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55961494
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50772112
54SPI1_23547873_ChIP-Seq_NB4_Human1.48769640
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48162358
56* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46777767
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45835139
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45486678
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44481990
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43980578
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43584233
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39423739
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36609015
64ZNF263_19887448_ChIP-Seq_K562_Human1.36538971
65MYC_18940864_ChIP-ChIP_HL60_Human1.24709770
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17429642
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16582199
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16319704
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16010194
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15744476
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15353194
72TFEB_21752829_ChIP-Seq_HELA_Human1.12998446
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12903810
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.12584230
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11347654
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07404566
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07364484
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07015129
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06677205
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.06460760
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04581050
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04351321
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04215889
84ELF5_23300383_ChIP-Seq_T47D_Human1.04177196
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03766354
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.03437752
87AR_21909140_ChIP-Seq_LNCAP_Human1.03177740
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01767807
89KDM5A_27292631_Chip-Seq_BREAST_Human0.98191983
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94874539
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94337089
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93888859
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93516988
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93213802
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93051056
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93051056
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.92360371
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91634362
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90993471
100* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89963814
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89857601
102CIITA_25753668_ChIP-Seq_RAJI_Human0.86512435
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85257526
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81100451
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81036440
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79644327
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79556039
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79507588
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78955266
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78572694
111* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76392860
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76025885
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75859539
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74463356
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74412254
116IRF8_27001747_Chip-Seq_BMDM_Mouse0.73927741
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73566093
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72825399
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.72243645
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71691322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.10602599
2MP0004957_abnormal_blastocyst_morpholog3.25613292
3MP0009785_altered_susceptibility_to2.93235214
4MP0002877_abnormal_melanocyte_morpholog2.79802982
5MP0002148_abnormal_hypersensitivity_rea2.79053364
6MP0001835_abnormal_antigen_presentation2.78092430
7MP0003186_abnormal_redox_activity2.62835929
8MP0003646_muscle_fatigue2.60863270
9MP0003136_yellow_coat_color2.53309353
10MP0003077_abnormal_cell_cycle2.40661201
11MP0008438_abnormal_cutaneous_collagen2.39628974
12MP0010094_abnormal_chromosome_stability2.37234470
13MP0003718_maternal_effect2.36399668
14MP0005671_abnormal_response_to2.31055171
15MP0005451_abnormal_body_composition2.22360667
16MP0009333_abnormal_splenocyte_physiolog2.21520117
17MP0003436_decreased_susceptibility_to2.19527199
18MP0008932_abnormal_embryonic_tissue2.19304851
19MP0005000_abnormal_immune_tolerance2.13670112
20MP0008260_abnormal_autophagy2.12996206
21MP0005084_abnormal_gallbladder_morpholo2.12692195
22MP0001986_abnormal_taste_sensitivity2.11313105
23MP0003724_increased_susceptibility_to2.10783433
24MP0003111_abnormal_nucleus_morphology2.04926881
25MP0005083_abnormal_biliary_tract2.03725446
26MP0008058_abnormal_DNA_repair2.03156047
27MP0003806_abnormal_nucleotide_metabolis1.98482800
28MP0002419_abnormal_innate_immunity1.95440144
29MP0005025_abnormal_response_to1.93276308
30MP0001529_abnormal_vocalization1.92611698
31MP0000372_irregular_coat_pigmentation1.88491220
32MP0006054_spinal_hemorrhage1.83448762
33MP0006036_abnormal_mitochondrial_physio1.79823292
34MP0000749_muscle_degeneration1.76899026
35MP0002452_abnormal_antigen_presenting1.74772148
36MP0005165_increased_susceptibility_to1.74695324
37MP0002723_abnormal_immune_serum1.73622710
38MP0006082_CNS_inflammation1.71921676
39MP0009379_abnormal_foot_pigmentation1.70678806
40MP0001800_abnormal_humoral_immune1.66765882
41MP0001819_abnormal_immune_cell1.62894912
42MP0002420_abnormal_adaptive_immunity1.62541265
43MP0008057_abnormal_DNA_replication1.59323820
44MP0001853_heart_inflammation1.57854816
45MP0010368_abnormal_lymphatic_system1.56752333
46MP0003566_abnormal_cell_adhesion1.53239749
47MP0005257_abnormal_intraocular_pressure1.51910277
48MP0005330_cardiomyopathy1.49628534
49MP0005501_abnormal_skin_physiology1.47339783
50MP0009053_abnormal_anal_canal1.46827787
51MP0008007_abnormal_cellular_replicative1.45824394
52MP0000343_altered_response_to1.45684329
53MP0000516_abnormal_urinary_system1.44271008
54MP0005367_renal/urinary_system_phenotyp1.44271008
55MP0003950_abnormal_plasma_membrane1.43328816
56MP0001542_abnormal_bone_strength1.42820300
57MP0005058_abnormal_lysosome_morphology1.42440113
58MP0001905_abnormal_dopamine_level1.38924608
59MP0002102_abnormal_ear_morphology1.37916488
60MP0008775_abnormal_heart_ventricle1.36972872
61MP0005623_abnormal_meninges_morphology1.36767309
62MP0001243_abnormal_dermal_layer1.36209679
63MP0002638_abnormal_pupillary_reflex1.35051167
64MP0006035_abnormal_mitochondrial_morpho1.34818026
65MP0002405_respiratory_system_inflammati1.34361255
66MP0005387_immune_system_phenotype1.32342797
67MP0001790_abnormal_immune_system1.32342797
68MP0002398_abnormal_bone_marrow1.32284191
69MP0003656_abnormal_erythrocyte_physiolo1.30781687
70MP0001879_abnormal_lymphatic_vessel1.27472529
71MP0000716_abnormal_immune_system1.26895891
72MP0000858_altered_metastatic_potential1.26247590
73MP0004782_abnormal_surfactant_physiolog1.25417621
74MP0003221_abnormal_cardiomyocyte_apopto1.25360606
75MP0000490_abnormal_crypts_of1.23183471
76MP0002277_abnormal_respiratory_mucosa1.22868094
77MP0002163_abnormal_gland_morphology1.22652796
78MP0002735_abnormal_chemical_nociception1.22543240
79MP0005408_hypopigmentation1.21526433
80MP0000689_abnormal_spleen_morphology1.20794373
81MP0002132_abnormal_respiratory_system1.19788652
82MP0002396_abnormal_hematopoietic_system1.18415515
83MP0000685_abnormal_immune_system1.17093208
84MP0003763_abnormal_thymus_physiology1.16545260
85MP0001845_abnormal_inflammatory_respons1.16313471
86MP0002429_abnormal_blood_cell1.16145463
87MP0004084_abnormal_cardiac_muscle1.15935025
88MP0002722_abnormal_immune_system1.12104003
89MP0002736_abnormal_nociception_after1.08096257
90MP0003786_premature_aging1.07463291
91MP0004381_abnormal_hair_follicle1.06121541
92MP0010030_abnormal_orbit_morphology1.05937425
93MP0002972_abnormal_cardiac_muscle1.05868419
94MP0002060_abnormal_skin_morphology1.04594934
95MP0001533_abnormal_skeleton_physiology1.02030124
96MP0000015_abnormal_ear_pigmentation1.01827288
97MP0008469_abnormal_protein_level1.00424808
98MP0002796_impaired_skin_barrier0.99957801
99MP0002332_abnormal_exercise_endurance0.97731421
100MP0003191_abnormal_cellular_cholesterol0.97256455
101MP0000647_abnormal_sebaceous_gland0.97161517
102MP0000358_abnormal_cell_content/0.96367153
103MP0002019_abnormal_tumor_incidence0.95751156
104MP0001881_abnormal_mammary_gland0.92521235
105MP0000750_abnormal_muscle_regeneration0.91956179
106MP0001697_abnormal_embryo_size0.90843410
107MP0009697_abnormal_copulation0.89492896
108MP0000313_abnormal_cell_death0.88298898
109MP0004233_abnormal_muscle_weight0.87950042
110MP0004215_abnormal_myocardial_fiber0.87608550
111MP0000350_abnormal_cell_proliferation0.86343496
112MP0001851_eye_inflammation0.85029178
113MP0010155_abnormal_intestine_physiology0.84992996
114MP0005464_abnormal_platelet_physiology0.83772017
115MP0002090_abnormal_vision0.83436893
116MP0001727_abnormal_embryo_implantation0.83399336
117MP0002177_abnormal_outer_ear0.81821841
118MP0004272_abnormal_basement_membrane0.81724816
119MP0005275_abnormal_skin_tensile0.81673383
120MP0003279_aneurysm0.80558012
121MP0005384_cellular_phenotype0.80002868
122MP0004947_skin_inflammation0.79981898
123MP0005397_hematopoietic_system_phenotyp0.79779249
124MP0001545_abnormal_hematopoietic_system0.79779249
125MP0004147_increased_porphyrin_level0.79372477
126MP0005164_abnormal_response_to0.78857315
127MP0001730_embryonic_growth_arrest0.77441393
128MP0000751_myopathy0.77259714
129MP0001968_abnormal_touch/_nociception0.77080914
130MP0003941_abnormal_skin_development0.76516673
131MP0004510_myositis0.76345807
132MP0009764_decreased_sensitivity_to0.76129893
133MP0005197_abnormal_uvea_morphology0.74759958
134MP0003448_altered_tumor_morphology0.74685546
135MP0000747_muscle_weakness0.74647382
136MP0006292_abnormal_olfactory_placode0.74139029
137MP0000427_abnormal_hair_cycle0.72443132
138MP0010352_gastrointestinal_tract_polyps0.71940421
139MP0003123_paternal_imprinting0.71344034
140MP0006276_abnormal_autonomic_nervous0.71106508
141MP0005266_abnormal_metabolism0.71057076
142MP0003011_delayed_dark_adaptation0.70843193
143MP0005075_abnormal_melanosome_morpholog0.69563505
144MP0000465_gastrointestinal_hemorrhage0.69384872
145MP0003303_peritoneal_inflammation0.69344223
146MP0003315_abnormal_perineum_morphology0.69047136
147MP0001188_hyperpigmentation0.68790539
148MP0005379_endocrine/exocrine_gland_phen0.68374889
149MP0001764_abnormal_homeostasis0.67875253
150* MP0002080_prenatal_lethality0.67239519
151MP0005621_abnormal_cell_physiology0.66163407
152MP0003828_pulmonary_edema0.61955427
153MP0001216_abnormal_epidermal_layer0.61681007
154MP0010771_integument_phenotype0.61623239
155MP0009763_increased_sensitivity_to0.60762779

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.46349203
2Mitochondrial inheritance (HP:0001427)4.19504898
3Abnormal mitochondria in muscle tissue (HP:0008316)3.96750531
4Hepatocellular necrosis (HP:0001404)3.91567424
5Recurrent abscess formation (HP:0002722)3.83921937
6Increased CSF lactate (HP:0002490)3.76967091
7Abnormality of cells of the erythroid lineage (HP:0012130)3.72887536
8Atrophy/Degeneration involving motor neurons (HP:0007373)3.59926511
9Abnormal number of erythroid precursors (HP:0012131)3.54656373
10Increased hepatocellular lipid droplets (HP:0006565)3.54018299
11Progressive macrocephaly (HP:0004481)3.51198875
12Hepatic necrosis (HP:0002605)3.50569067
13Acute encephalopathy (HP:0006846)3.49982830
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.45441412
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39599446
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39599446
17Recurrent bacterial skin infections (HP:0005406)3.38790875
18Increased serum pyruvate (HP:0003542)3.36167649
19Abnormality of glycolysis (HP:0004366)3.36167649
203-Methylglutaconic aciduria (HP:0003535)3.33524912
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.24074649
22Exertional dyspnea (HP:0002875)3.19215875
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.14544402
24Reduced subcutaneous adipose tissue (HP:0003758)3.14387753
25Lipid accumulation in hepatocytes (HP:0006561)3.06176066
26Reticulocytopenia (HP:0001896)3.06055859
27Renal Fanconi syndrome (HP:0001994)2.98356480
28Cerebral hypomyelination (HP:0006808)2.96303720
29Eczematoid dermatitis (HP:0000976)2.96037438
30Increased serum lactate (HP:0002151)2.93255753
31Breast hypoplasia (HP:0003187)2.92506131
32Birth length less than 3rd percentile (HP:0003561)2.89647300
33Limb-girdle muscle atrophy (HP:0003797)2.77746077
34Premature rupture of membranes (HP:0001788)2.76166413
35Aplastic anemia (HP:0001915)2.74533306
36Poor head control (HP:0002421)2.73675300
37Abnormality of the anterior horn cell (HP:0006802)2.70241755
38Degeneration of anterior horn cells (HP:0002398)2.70241755
39Macrocytic anemia (HP:0001972)2.70238786
40Congenital ichthyosiform erythroderma (HP:0007431)2.66766180
41Carpal bone hypoplasia (HP:0001498)2.66042596
42Parakeratosis (HP:0001036)2.65570128
43Respiratory failure (HP:0002878)2.61573267
44Type I transferrin isoform profile (HP:0003642)2.58655060
45Autoamputation (HP:0001218)2.56896753
46Abnormality of macrophages (HP:0004311)2.54129195
47Exercise intolerance (HP:0003546)2.52606508
48Respiratory difficulties (HP:0002880)2.51781869
49Lactic acidosis (HP:0003128)2.47084800
50Fasciculations (HP:0002380)2.45719701
51Increased intramyocellular lipid droplets (HP:0012240)2.43424969
52Pallor (HP:0000980)2.41583901
53Amyotrophic lateral sclerosis (HP:0007354)2.41563408
54Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41147286
55Agnosia (HP:0010524)2.39307526
56Shoulder girdle muscle weakness (HP:0003547)2.39086706
57Chronic obstructive pulmonary disease (HP:0006510)2.36713481
58Obstructive lung disease (HP:0006536)2.36713481
59Elevated erythrocyte sedimentation rate (HP:0003565)2.34621775
60Hand muscle atrophy (HP:0009130)2.33587215
61Rough bone trabeculation (HP:0100670)2.33556719
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33179166
63Generalized aminoaciduria (HP:0002909)2.29773784
64Abnormality of glycolipid metabolism (HP:0010969)2.28346816
65Abnormality of liposaccharide metabolism (HP:0010968)2.28346816
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.28346816
67Irregular epiphyses (HP:0010582)2.27540105
68Oral leukoplakia (HP:0002745)2.26393402
69Increased IgM level (HP:0003496)2.25270570
70Vertebral compression fractures (HP:0002953)2.22366616
71Upper motor neuron abnormality (HP:0002127)2.19447725
72Microretrognathia (HP:0000308)2.18214797
73Multiple enchondromatosis (HP:0005701)2.18187245
74Leukodystrophy (HP:0002415)2.17413155
75Abnormality of the distal phalanges of the toes (HP:0010182)2.15195647
76Opisthotonus (HP:0002179)2.12914328
77Nausea (HP:0002018)2.11989551
78Delayed gross motor development (HP:0002194)2.07571321
79Abnormality of the umbilical cord (HP:0010881)2.06350504
80Axonal loss (HP:0003447)2.04682289
81Cerebral edema (HP:0002181)2.04085696
82Mediastinal lymphadenopathy (HP:0100721)2.03972913
83Vacuolated lymphocytes (HP:0001922)2.03292947
84X-linked dominant inheritance (HP:0001423)2.01683582
85Abnormal gallbladder physiology (HP:0012438)2.01585844
86Cholecystitis (HP:0001082)2.01585844
87Congenital, generalized hypertrichosis (HP:0004540)2.01508188
88Hepatosplenomegaly (HP:0001433)2.01021108
89Palpitations (HP:0001962)2.00993325
90Myositis (HP:0100614)1.99726928
91Petechiae (HP:0000967)1.99297185
92Optic disc pallor (HP:0000543)1.98689547
93Abnormality of the motor neurons (HP:0002450)1.96432412
94Abnormal neuron morphology (HP:0012757)1.96432412
95Retinal dysplasia (HP:0007973)1.96144262
96Exercise-induced muscle cramps (HP:0003710)1.95577737
97Increased muscle lipid content (HP:0009058)1.95207475
98Achilles tendon contracture (HP:0001771)1.94339271
99Premature graying of hair (HP:0002216)1.93790540
100CNS demyelination (HP:0007305)1.93337226
101Reduced antithrombin III activity (HP:0001976)1.93182827
102Abnormality of the musculature of the pelvis (HP:0001469)1.92753287
103Abnormality of the hip-girdle musculature (HP:0001445)1.92753287
104Upper limb muscle weakness (HP:0003484)1.92069290
105Premature ovarian failure (HP:0008209)1.91430860
106Distal lower limb muscle weakness (HP:0009053)1.90902253
107Abnormalities of placenta or umbilical cord (HP:0001194)1.89988329
108Abnormal trabecular bone morphology (HP:0100671)1.89843098
109Stenosis of the external auditory canal (HP:0000402)1.88458627
110Cleft eyelid (HP:0000625)1.88187044
111IgM deficiency (HP:0002850)1.88006209
112Nemaline bodies (HP:0003798)1.86086571
113Postnatal microcephaly (HP:0005484)1.85965984
114Amniotic constriction ring (HP:0009775)1.85733348
115Abnormality of placental membranes (HP:0011409)1.85733348
116Pulmonary fibrosis (HP:0002206)1.85222416
117Fatigue (HP:0012378)1.85154195
118Recurrent skin infections (HP:0001581)1.84668422
119Hypokinesia (HP:0002375)1.84154856
120Abnormal protein N-linked glycosylation (HP:0012347)1.83972371
121Abnormal protein glycosylation (HP:0012346)1.83972371
122Abnormal glycosylation (HP:0012345)1.83972371
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83972371
124Retrobulbar optic neuritis (HP:0100654)1.83066508
125Optic neuritis (HP:0100653)1.83066508
126CNS hypomyelination (HP:0003429)1.81947373
127Spastic paraparesis (HP:0002313)1.81651876
128Mucosal telangiectasiae (HP:0100579)1.81432606
129Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81266017
130Aplasia/Hypoplasia of the patella (HP:0006498)1.81046919
131Abnormal umbilical cord blood vessels (HP:0011403)1.80840915
132Single umbilical artery (HP:0001195)1.80840915
133Abnormality of the fetal cardiovascular system (HP:0010948)1.80840915
134Follicular hyperkeratosis (HP:0007502)1.80613603
135Sparse eyelashes (HP:0000653)1.80541927
136Distal upper limb amyotrophy (HP:0007149)1.80415558
137Upper limb amyotrophy (HP:0009129)1.80415558
138Adrenal hypoplasia (HP:0000835)1.79496764
139Orthostatic hypotension (HP:0001278)1.79364827
140Patellar aplasia (HP:0006443)1.78763897
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78651681
142Abnormality of alanine metabolism (HP:0010916)1.78651681
143Hyperalaninemia (HP:0003348)1.78651681
144Pelvic girdle muscle weakness (HP:0003749)1.78076345
145Abnormality of renal resorption (HP:0011038)1.78026151
146Stomatitis (HP:0010280)1.75227434
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74875663
148Secondary amenorrhea (HP:0000869)1.74700436
149Pancytopenia (HP:0001876)1.74632702
150Cutaneous photosensitivity (HP:0000992)1.74258742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.67553895
2NME23.46478264
3EIF2AK13.38197779
4ARAF3.30298933
5PIM22.76367702
6VRK22.65415167
7WEE12.62827257
8MAP3K122.57043573
9STK162.51956092
10MST42.45462496
11TESK22.30511752
12TRIM282.18411165
13EIF2AK32.08817492
14VRK12.06561738
15PDK21.99986767
16PBK1.99533940
17PLK41.97636173
18RIPK41.93108052
19BRAF1.88356060
20BRSK21.88232627
21PAK41.86317556
22BLK1.82914513
23MAP3K141.69258787
24LIMK11.67077224
25SRPK11.45193845
26ERBB31.45146120
27TLK11.44787634
28EPHB21.38556410
29BCKDK1.36521408
30NME11.36049112
31SCYL21.34467571
32IRAK41.28265797
33ABL21.27049913
34TESK11.24601575
35SIK31.24218764
36PNCK1.23303213
37BMPR21.20184388
38CDK191.17002739
39IRAK31.15181257
40TSSK61.11932430
41CCNB11.11112462
42EIF2AK21.09771749
43NEK91.08477231
44PLK31.08327329
45TXK1.08243613
46GRK51.07630878
47EPHA21.07079858
48ACVR1B1.06615269
49PLK11.01312383
50AURKA1.00089081
51IKBKB0.99787245
52BRSK10.98829215
53RPS6KA40.98319091
54DYRK20.97838541
55MAP3K110.96869273
56TEC0.93340400
57ERBB40.93150976
58CDK80.91537907
59BCR0.90710123
60TBK10.90516498
61MKNK10.90422741
62MARK30.89958554
63TYK20.85651714
64NUAK10.84472564
65GRK70.84044347
66EPHB10.83619145
67RAF10.82901689
68STK240.82676454
69MYLK0.79004704
70MST1R0.77971558
71YES10.74845813
72STK30.74741639
73TAF10.74324388
74DAPK10.74268908
75SYK0.72893120
76CSNK1G30.72330865
77DMPK0.71720190
78MKNK20.71393416
79CLK10.71072995
80KDR0.70888376
81PLK20.70095694
82CDC70.69751945
83STK100.69560751
84NEK20.69356906
85MET0.68879577
86TTK0.68759169
87PIM10.68507030
88PAK10.67835811
89CDK180.66548710
90CSNK1A1L0.65175978
91ZAP700.64313741
92MOS0.64030376
93CSNK1G20.63790510
94JAK30.62721127
95CASK0.61371205
96CSNK2A10.61263711
97KSR10.61214214
98NEK10.61144041
99LYN0.58522370
100AURKB0.56949059
101ZAK0.56613799
102KIT0.56521018
103CDK11A0.56420679
104CDK150.55989026
105IKBKE0.55181940
106NLK0.53756690
107MAP4K10.52010673
108CDK60.51823221
109MAP3K50.51007652
110ILK0.50967041
111DAPK30.50932635
112STK38L0.50828663
113MAP3K80.50110297
114CDK70.50092167
115MAP3K130.48368679
116DYRK30.48199752
117ADRBK20.45850163
118MAP2K70.43811689
119BTK0.43586007
120MUSK0.43099396
121PRKCD0.43025353
122TRPM70.42273710
123MAP3K30.41935939
124STK390.41693420
125RPS6KA50.41453288
126PIK3CA0.40539304
127CHEK20.39527058
128CSNK2A20.38265197
129PTK20.38135780
130MAPKAPK50.35786202
131CDK140.35494430
132LRRK20.34966196
133CDK90.33313297
134ATR0.32789869
135STK40.32109503
136PRKCI0.31738784
137CSNK1G10.31540329

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.01285809
2Ribosome_Homo sapiens_hsa030104.24347069
3RNA polymerase_Homo sapiens_hsa030203.77311598
4Oxidative phosphorylation_Homo sapiens_hsa001903.57910140
5Parkinsons disease_Homo sapiens_hsa050123.07327365
6DNA replication_Homo sapiens_hsa030302.87420157
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49520161
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38162018
9Protein export_Homo sapiens_hsa030602.33949824
10Huntingtons disease_Homo sapiens_hsa050162.30944105
11Pyrimidine metabolism_Homo sapiens_hsa002402.30688109
12Mismatch repair_Homo sapiens_hsa034302.24083244
13Homologous recombination_Homo sapiens_hsa034402.13804984
14Alzheimers disease_Homo sapiens_hsa050102.09403250
15Nucleotide excision repair_Homo sapiens_hsa034202.02998712
16Spliceosome_Homo sapiens_hsa030401.91142151
17Base excision repair_Homo sapiens_hsa034101.88367653
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88298692
19Basal transcription factors_Homo sapiens_hsa030221.83915157
20RNA transport_Homo sapiens_hsa030131.55018602
21Folate biosynthesis_Homo sapiens_hsa007901.40709354
22Graft-versus-host disease_Homo sapiens_hsa053321.34526005
23Legionellosis_Homo sapiens_hsa051341.32617326
24Cell cycle_Homo sapiens_hsa041101.26919480
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26377215
26Collecting duct acid secretion_Homo sapiens_hsa049661.25765858
27Rheumatoid arthritis_Homo sapiens_hsa053231.21222472
28RNA degradation_Homo sapiens_hsa030181.21160544
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19736928
30Purine metabolism_Homo sapiens_hsa002301.17934202
31Epstein-Barr virus infection_Homo sapiens_hsa051691.16314856
32Fanconi anemia pathway_Homo sapiens_hsa034601.12921275
33Asthma_Homo sapiens_hsa053101.08547720
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08437642
35Allograft rejection_Homo sapiens_hsa053301.08199028
36Non-homologous end-joining_Homo sapiens_hsa034501.07800478
37Phagosome_Homo sapiens_hsa041451.02900180
38Sulfur metabolism_Homo sapiens_hsa009201.02263658
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02220988
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01919532
41Regulation of autophagy_Homo sapiens_hsa041400.99342082
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97371209
43Viral myocarditis_Homo sapiens_hsa054160.95687356
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95466335
45Carbon metabolism_Homo sapiens_hsa012000.94838635
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93695035
47Leishmaniasis_Homo sapiens_hsa051400.93425355
48Pyruvate metabolism_Homo sapiens_hsa006200.88569652
49Shigellosis_Homo sapiens_hsa051310.87881918
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86902556
51Galactose metabolism_Homo sapiens_hsa000520.84235135
52Cardiac muscle contraction_Homo sapiens_hsa042600.79840462
53Glutathione metabolism_Homo sapiens_hsa004800.79193918
54Vibrio cholerae infection_Homo sapiens_hsa051100.78979958
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76086674
56Pertussis_Homo sapiens_hsa051330.74864580
57Arachidonic acid metabolism_Homo sapiens_hsa005900.74729268
58Herpes simplex infection_Homo sapiens_hsa051680.72859666
59Vitamin B6 metabolism_Homo sapiens_hsa007500.72742718
60Biosynthesis of amino acids_Homo sapiens_hsa012300.72329879
61p53 signaling pathway_Homo sapiens_hsa041150.72319832
62Pentose phosphate pathway_Homo sapiens_hsa000300.72009599
63Primary immunodeficiency_Homo sapiens_hsa053400.71604373
64Antigen processing and presentation_Homo sapiens_hsa046120.71109985
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.70861839
66N-Glycan biosynthesis_Homo sapiens_hsa005100.70834168
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69281668
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68349852
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67359473
70Salmonella infection_Homo sapiens_hsa051320.65437183
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65228196
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64309930
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.64029070
74Tuberculosis_Homo sapiens_hsa051520.63974667
75Bladder cancer_Homo sapiens_hsa052190.63385989
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63145325
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61657689
78Sulfur relay system_Homo sapiens_hsa041220.61316037
79Autoimmune thyroid disease_Homo sapiens_hsa053200.60774858
80Steroid biosynthesis_Homo sapiens_hsa001000.60109471
81Fatty acid elongation_Homo sapiens_hsa000620.58147756
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57909421
83Type I diabetes mellitus_Homo sapiens_hsa049400.56585373
84Hematopoietic cell lineage_Homo sapiens_hsa046400.53738496
85Malaria_Homo sapiens_hsa051440.53543284
86Measles_Homo sapiens_hsa051620.52992609
87Sphingolipid metabolism_Homo sapiens_hsa006000.51496637
88Apoptosis_Homo sapiens_hsa042100.51473123
89One carbon pool by folate_Homo sapiens_hsa006700.51049173
90Metabolic pathways_Homo sapiens_hsa011000.48546435
91Oocyte meiosis_Homo sapiens_hsa041140.47831787
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46785974
93Lysosome_Homo sapiens_hsa041420.46220619
94Phenylalanine metabolism_Homo sapiens_hsa003600.45912176
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45194278
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44103138
97Other glycan degradation_Homo sapiens_hsa005110.43752321
98Influenza A_Homo sapiens_hsa051640.43563734
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43527587
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36416020
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35861521
102Ether lipid metabolism_Homo sapiens_hsa005650.35408938
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.33789890
104beta-Alanine metabolism_Homo sapiens_hsa004100.33765137
105Propanoate metabolism_Homo sapiens_hsa006400.33628294
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32233606
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.29035657
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28182341
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26818355
110Hepatitis B_Homo sapiens_hsa051610.26327445
111mRNA surveillance pathway_Homo sapiens_hsa030150.24315582
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23929184
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.23166455
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21839821
115Linoleic acid metabolism_Homo sapiens_hsa005910.20588741
116* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17920141
117African trypanosomiasis_Homo sapiens_hsa051430.17854040
118TNF signaling pathway_Homo sapiens_hsa046680.17852724
119Thyroid cancer_Homo sapiens_hsa052160.15991364
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15983701
121Fructose and mannose metabolism_Homo sapiens_hsa000510.15254868
122Osteoclast differentiation_Homo sapiens_hsa043800.14771936

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