UBAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)7.78061686
2auditory behavior (GO:0031223)6.02294215
3cell morphogenesis involved in neuron differentiation (GO:0048667)4.99374834
4epithelial cell differentiation involved in prostate gland development (GO:0060742)4.57432058
5startle response (GO:0001964)4.33766198
6negative regulation of erythrocyte differentiation (GO:0045647)4.20044517
7response to peptidoglycan (GO:0032494)4.20041697
8regulation of podosome assembly (GO:0071801)4.15291972
9cellular response to vitamin D (GO:0071305)4.01240740
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00518092
11negative regulation of cell killing (GO:0031342)4.00518092
12low-density lipoprotein particle clearance (GO:0034383)3.97454617
13neutrophil activation involved in immune response (GO:0002283)3.69986796
14detection of other organism (GO:0098543)3.68396913
15macrophage activation involved in immune response (GO:0002281)3.61344032
16mesenchymal-epithelial cell signaling (GO:0060638)3.58864267
17regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.53729250
18mechanosensory behavior (GO:0007638)3.51669422
19protein localization to endosome (GO:0036010)3.46928037
20detection of bacterium (GO:0016045)3.46810606
21positive regulation of nitric-oxide synthase activity (GO:0051000)3.42894602
22innervation (GO:0060384)3.37594256
23response to muramyl dipeptide (GO:0032495)3.35800416
24morphogenesis of an endothelium (GO:0003159)3.34331082
25endothelial tube morphogenesis (GO:0061154)3.34331082
26cellular response to prostaglandin stimulus (GO:0071379)3.33611361
27cellular response to vitamin (GO:0071295)3.27801194
28positive regulation of chemokine biosynthetic process (GO:0045080)3.24212879
29positive regulation of gamma-delta T cell activation (GO:0046645)3.24200575
30glycine metabolic process (GO:0006544)3.23740225
31regulation of mast cell degranulation (GO:0043304)3.23588192
32heparin biosynthetic process (GO:0030210)3.23253371
33heparin metabolic process (GO:0030202)3.23253371
34detection of external biotic stimulus (GO:0098581)3.18251892
35detection of molecule of bacterial origin (GO:0032490)3.18010255
36regulation of leukocyte degranulation (GO:0043300)3.17853881
37negative regulation of interleukin-12 production (GO:0032695)3.15195865
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14173902
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.14173902
40modulation by symbiont of host immune response (GO:0052553)3.14173902
41positive regulation by symbiont of host defense response (GO:0052509)3.14173902
42modulation by symbiont of host defense response (GO:0052031)3.14173902
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14173902
44positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.13464672
45germinal center formation (GO:0002467)3.10594728
46response to auditory stimulus (GO:0010996)3.10244897
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09032536
48response to host (GO:0075136)3.08886325
49response to host defenses (GO:0052200)3.08886325
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08886325
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08433898
52response to host immune response (GO:0052572)3.08433898
53serine family amino acid catabolic process (GO:0009071)3.06805901
54regulation of T-helper 2 cell differentiation (GO:0045628)3.06137615
55lung-associated mesenchyme development (GO:0060484)3.05133743
563-UTR-mediated mRNA stabilization (GO:0070935)3.04870454
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04863194
58lysine catabolic process (GO:0006554)3.02973358
59lysine metabolic process (GO:0006553)3.02973358
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02296281
61protein kinase C signaling (GO:0070528)3.00792917
62plasma lipoprotein particle clearance (GO:0034381)2.99659532
63barbed-end actin filament capping (GO:0051016)2.99513628
64cysteine metabolic process (GO:0006534)2.98835541
65positive regulation of monooxygenase activity (GO:0032770)2.98052406
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97590687
67fructose metabolic process (GO:0006000)2.96913445
68histone H2A monoubiquitination (GO:0035518)2.95991034
692-oxoglutarate metabolic process (GO:0006103)2.95822309
70macroautophagy (GO:0016236)2.93880467
71folic acid transport (GO:0015884)2.93767961
72regulation of myeloid leukocyte mediated immunity (GO:0002886)2.92298743
73cellular extravasation (GO:0045123)2.91292135
74antigen processing and presentation of endogenous antigen (GO:0019883)2.91139273
75positive regulation of cellular amide metabolic process (GO:0034250)2.89185568
76regulation of interferon-beta biosynthetic process (GO:0045357)2.88367076
77regulation of mast cell activation involved in immune response (GO:0033006)2.88286951
78cellular response to thyroid hormone stimulus (GO:0097067)2.87535564
79midgut development (GO:0007494)2.86996217
80granulocyte activation (GO:0036230)2.83706965
81urea metabolic process (GO:0019627)2.82481010
82urea cycle (GO:0000050)2.82481010
83detection of biotic stimulus (GO:0009595)2.82177941
84genitalia morphogenesis (GO:0035112)2.82142012
85gland morphogenesis (GO:0022612)2.81300296
86negative regulation of cell fate specification (GO:0009996)2.81072856
87G-protein coupled receptor internalization (GO:0002031)2.77926964
88regulation of cardioblast differentiation (GO:0051890)2.77661020
89nuclear pore complex assembly (GO:0051292)2.77565184
90heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.77151989
91stress fiber assembly (GO:0043149)2.76975972
92NIK/NF-kappaB signaling (GO:0038061)2.76150804
93amino-acid betaine metabolic process (GO:0006577)2.76012183
94nephron tubule formation (GO:0072079)2.74825013
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.74451479
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73869387
97positive regulation of endothelial cell differentiation (GO:0045603)2.73097100
98neutrophil activation (GO:0042119)2.72748927
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72253320
100leukocyte aggregation (GO:0070486)2.72024690
101modulation by symbiont of host cellular process (GO:0044068)2.71825485
102positive regulation of organelle assembly (GO:1902117)2.70766307
103protein carboxylation (GO:0018214)2.70088989
104peptidyl-glutamic acid carboxylation (GO:0017187)2.70088989
105nuclear pore organization (GO:0006999)2.70005744
106regulation of cholesterol homeostasis (GO:2000188)2.69114800
107response to laminar fluid shear stress (GO:0034616)2.68592360
108regulation of necroptotic process (GO:0060544)2.68339427
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67997236
110positive regulation of triglyceride biosynthetic process (GO:0010867)2.67458300
111hypotonic response (GO:0006971)2.66515638
112regulation of regulated secretory pathway (GO:1903305)2.65944536
113negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.65863593
114pore complex assembly (GO:0046931)2.65760217
115negative regulation of type 2 immune response (GO:0002829)2.64955669
116macrophage activation (GO:0042116)2.64505677
117DNA double-strand break processing (GO:0000729)2.64417961
118ruffle organization (GO:0031529)2.63284950
119morphogenesis of an epithelial fold (GO:0060571)2.63192828
120pathway-restricted SMAD protein phosphorylation (GO:0060389)2.61703032
121cellular response to nutrient (GO:0031670)2.61260863
122protoporphyrinogen IX metabolic process (GO:0046501)2.60512809
123regulation of gamma-delta T cell activation (GO:0046643)2.58986604
124serine family amino acid metabolic process (GO:0009069)2.58619694
125endothelial cell morphogenesis (GO:0001886)2.58171097
126negative regulation of necroptotic process (GO:0060546)2.57124550
127regulation of macrophage cytokine production (GO:0010935)2.56163230
128pinocytosis (GO:0006907)2.55952803
129regulation of heterotypic cell-cell adhesion (GO:0034114)2.55741382
130positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54929299
131alpha-linolenic acid metabolic process (GO:0036109)2.54508002
132regulation of necrotic cell death (GO:0010939)2.54429478
133neutrophil mediated immunity (GO:0002446)2.54209127
134regulation of chromosome segregation (GO:0051983)2.53872116
135positive regulation of leukocyte degranulation (GO:0043302)2.53204680
136regulation of cholesterol storage (GO:0010885)2.52461210
137DNA-dependent DNA replication (GO:0006261)2.52210910
138negative regulation of interleukin-17 production (GO:0032700)2.51948637
139negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51904955
140regulation of phospholipid biosynthetic process (GO:0071071)2.51699871
141histone H2A ubiquitination (GO:0033522)2.50644628
142negative regulation of leukocyte mediated immunity (GO:0002704)2.49074163
143positive regulation of glycoprotein metabolic process (GO:1903020)2.49023714
144positive regulation of fatty acid beta-oxidation (GO:0032000)2.48910342
145negative regulation of fibrinolysis (GO:0051918)2.48564436
146positive regulation of triglyceride metabolic process (GO:0090208)2.48514021
147dorsal/ventral axis specification (GO:0009950)2.47589424
148regulation of cilium movement (GO:0003352)2.47568408
149interferon-gamma secretion (GO:0072643)2.47480567
150negative regulation of lymphocyte mediated immunity (GO:0002707)2.47015303
151positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45815787
152pyrimidine dimer repair (GO:0006290)2.45529700
153very-low-density lipoprotein particle assembly (GO:0034379)2.45506304
154hemoglobin metabolic process (GO:0020027)2.45117168
155cellular response to arsenic-containing substance (GO:0071243)2.44859615
156response to arsenic-containing substance (GO:0046685)2.44734909
157mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44614186
158plasma lipoprotein particle assembly (GO:0034377)2.44286586
159erythrocyte development (GO:0048821)2.42829645
160regulation of type 2 immune response (GO:0002828)2.39946742
161positive regulation of lipid catabolic process (GO:0050996)2.39260511
162nitrogen cycle metabolic process (GO:0071941)2.39239985
163protein-lipid complex assembly (GO:0065005)2.39175034
164regulation of early endosome to late endosome transport (GO:2000641)2.37821980
165regulation of protein polyubiquitination (GO:1902914)2.37615010
166embryonic foregut morphogenesis (GO:0048617)2.37532329
167myeloid cell activation involved in immune response (GO:0002275)2.37378460
168modulation by virus of host process (GO:0019054)2.36476229
169negative regulation of protein localization to plasma membrane (GO:1903077)2.35614113
170regulation of platelet aggregation (GO:0090330)2.34698757
171positive regulation of macrophage cytokine production (GO:0060907)2.33485590
172embryonic process involved in female pregnancy (GO:0060136)2.32980862
173immunoglobulin mediated immune response (GO:0016064)2.32133600
174positive regulation of Cdc42 GTPase activity (GO:0043089)2.29996994
175regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.27844371
176positive regulation of mast cell activation (GO:0033005)2.27600704
177response to thyroid hormone (GO:0097066)2.26620158
178microglial cell activation (GO:0001774)2.25172031
179leukocyte migration involved in inflammatory response (GO:0002523)2.24862197
180regulation of B cell receptor signaling pathway (GO:0050855)2.22845835
181positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.22241266
182I-kappaB phosphorylation (GO:0007252)2.21441734
183negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.21193842
184myeloid cell development (GO:0061515)2.20213768
185type I interferon signaling pathway (GO:0060337)2.20103689
186cellular response to type I interferon (GO:0071357)2.20103689
187regulation of gamma-delta T cell differentiation (GO:0045586)2.19758794
188positive regulation of type 2 immune response (GO:0002830)2.19153053
189negative regulation of innate immune response (GO:0045824)2.17909378
190regulation of defense response to virus by virus (GO:0050690)2.17899583
191cellular response to virus (GO:0098586)2.17760204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.37684227
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.22820319
3E2F7_22180533_ChIP-Seq_HELA_Human3.98743343
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.84623199
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.53193803
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.22578170
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.21532012
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.75500289
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.74282502
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48919741
11VDR_21846776_ChIP-Seq_THP-1_Human2.45025585
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41936247
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.36053613
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.33869643
15CLOCK_20551151_ChIP-Seq_293T_Human2.31606767
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20864251
17AR_21909140_ChIP-Seq_LNCAP_Human2.16561554
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15823737
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14696428
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09974533
21LXR_22292898_ChIP-Seq_THP-1_Human2.07674817
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06852249
23VDR_24763502_ChIP-Seq_THP-1_Human2.02715121
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98860208
25* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96751328
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91492565
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87042851
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84146122
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81208403
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78257979
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76289994
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76164805
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68527566
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64251654
35RACK7_27058665_Chip-Seq_MCF-7_Human1.64213272
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62749792
37SPI1_23127762_ChIP-Seq_K562_Human1.62294552
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61565369
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.58430082
40* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57417157
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57404001
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57362811
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56812740
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55162717
45KDM2B_26808549_Chip-Seq_K562_Human1.54588693
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53637701
47ATF3_27146783_Chip-Seq_COLON_Human1.52317889
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50106272
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.47158867
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47154972
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45374167
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42111428
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.42080236
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41138388
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38777735
56ZNF263_19887448_ChIP-Seq_K562_Human1.38491821
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36419459
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.34300531
59TFEB_21752829_ChIP-Seq_HELA_Human1.33710762
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33235050
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31606181
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30587823
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30075212
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27846857
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27195175
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26701867
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25357726
68* SPI1_23547873_ChIP-Seq_NB4_Human1.25216315
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24647840
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23511521
71* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22685913
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22081504
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21473013
74RUNX_20019798_ChIP-Seq_JUKART_Human1.20253267
75* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19371704
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.19004845
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.18936554
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.17724729
79GATA1_22025678_ChIP-Seq_K562_Human1.17251837
80* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16806476
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16688185
82MAF_26560356_Chip-Seq_TH1_Human1.16615452
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16238595
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16175945
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15983257
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15814600
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.15245783
88KDM5A_27292631_Chip-Seq_BREAST_Human1.14867162
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14848181
90MYC_22102868_ChIP-Seq_BL_Human1.13520647
91* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13281608
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13097137
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12542284
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12031733
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.11087888
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10769746
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10756810
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10567257
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10321486
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09621172
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09516133
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09516133
103* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09406548
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08280920
105SMC4_20622854_ChIP-Seq_HELA_Human1.08226152
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08155915
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07458168
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07261606
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06602445
110E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06542714
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05404023
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05360708
113* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05275208
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04588209
115KDM2B_26808549_Chip-Seq_DND41_Human1.03678515
116GATA6_25053715_ChIP-Seq_YYC3_Human1.03655888
117GATA1_19941826_ChIP-Seq_K562_Human1.03301796
118UTX_26944678_Chip-Seq_JUKART_Human1.02481282
119TCF7_22412390_ChIP-Seq_EML_Mouse1.01893298
120BCOR_27268052_Chip-Seq_Bcells_Human1.01615321
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01123661
122MYB_26560356_Chip-Seq_TH2_Human1.00969798
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00584749
124MYB_26560356_Chip-Seq_TH1_Human0.99444878
125CREB1_26743006_Chip-Seq_LNCaP_Human0.99270105
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99158698
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97441579
128P68_20966046_ChIP-Seq_HELA_Human0.97332228
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96281545
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.96164335
131GATA4_25053715_ChIP-Seq_YYC3_Human0.94751760
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93604674
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.93470901
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93227641
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.92590100
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91337545
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90324916
138NCOR1_26117541_ChIP-Seq_K562_Human0.90302910
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89679753
140MAF_26560356_Chip-Seq_TH2_Human0.89638747
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89302559
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88507536
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88282155
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87935030
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87261777
146GATA2_19941826_ChIP-Seq_K562_Human0.86468444
147* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86201914
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85870854
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85513632
150SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85310729
151SCL_19346495_ChIP-Seq_HPC-7_Human0.85197711
152* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84762366
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84047636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.70515650
2MP0005248_abnormal_Harderian_gland3.36940371
3MP0003724_increased_susceptibility_to3.26013392
4MP0009840_abnormal_foam_cell3.15646215
5MP0002139_abnormal_hepatobiliary_system3.11043603
6MP0003303_peritoneal_inflammation3.10769545
7MP0006054_spinal_hemorrhage3.03906711
8MP0005360_urolithiasis2.83918623
9MP0003806_abnormal_nucleotide_metabolis2.60490394
10MP0004130_abnormal_muscle_cell2.59328839
11MP0003436_decreased_susceptibility_to2.47020043
12MP0008961_abnormal_basal_metabolism2.40776214
13MP0003656_abnormal_erythrocyte_physiolo2.26147803
14MP0005365_abnormal_bile_salt2.11554174
15MP0003828_pulmonary_edema2.09391010
16MP0003705_abnormal_hypodermis_morpholog2.00811469
17MP0005076_abnormal_cell_differentiation2.00032206
18MP0004510_myositis1.97135179
19MP0010307_abnormal_tumor_latency1.95655661
20MP0003075_altered_response_to1.90866287
21MP0005085_abnormal_gallbladder_physiolo1.86779660
22MP0005058_abnormal_lysosome_morphology1.84697210
23MP0002148_abnormal_hypersensitivity_rea1.75786001
24MP0005257_abnormal_intraocular_pressure1.75303864
25MP0000537_abnormal_urethra_morphology1.74986896
26MP0001835_abnormal_antigen_presentation1.74633719
27MP0000685_abnormal_immune_system1.66299679
28MP0008004_abnormal_stomach_pH1.64015429
29MP0005387_immune_system_phenotype1.61199282
30MP0001790_abnormal_immune_system1.61199282
31MP0005167_abnormal_blood-brain_barrier1.60672301
32MP0002723_abnormal_immune_serum1.57489643
33MP0009278_abnormal_bone_marrow1.57110804
34MP0005409_darkened_coat_color1.53034749
35MP0002452_abnormal_antigen_presenting1.52977161
36MP0008875_abnormal_xenobiotic_pharmacok1.51985075
37MP0002420_abnormal_adaptive_immunity1.49664396
38MP0001915_intracranial_hemorrhage1.48381026
39MP0001819_abnormal_immune_cell1.48007119
40MP0010352_gastrointestinal_tract_polyps1.47872227
41MP0005083_abnormal_biliary_tract1.46399264
42MP0001800_abnormal_humoral_immune1.46270044
43MP0003329_amyloid_beta_deposits1.44929118
44MP0003111_abnormal_nucleus_morphology1.44749356
45MP0002998_abnormal_bone_remodeling1.43472154
46MP0002405_respiratory_system_inflammati1.42628906
47MP0001849_ear_inflammation1.41072624
48MP0000609_abnormal_liver_physiology1.38718600
49MP0009333_abnormal_splenocyte_physiolog1.38304070
50MP0010329_abnormal_lipoprotein_level1.38218340
51MP0000343_altered_response_to1.36689108
52MP0002653_abnormal_ependyma_morphology1.36582039
53MP0000604_amyloidosis1.35400120
54MP0003091_abnormal_cell_migration1.34818669
55MP0002796_impaired_skin_barrier1.31951330
56MP0010155_abnormal_intestine_physiology1.31741165
57MP0008775_abnormal_heart_ventricle1.29790493
58MP0002736_abnormal_nociception_after1.29484645
59MP0001851_eye_inflammation1.26965190
60MP0003763_abnormal_thymus_physiology1.24096379
61MP0003195_calcinosis1.23010167
62MP0002398_abnormal_bone_marrow1.22527848
63MP0010030_abnormal_orbit_morphology1.22293656
64MP0003300_gastrointestinal_ulcer1.21607712
65MP0003890_abnormal_embryonic-extraembry1.21057575
66MP0001533_abnormal_skeleton_physiology1.20109367
67MP0004233_abnormal_muscle_weight1.19806909
68MP0005220_abnormal_exocrine_pancreas1.18514441
69MP0004947_skin_inflammation1.15309769
70MP0000566_synostosis1.14303641
71MP0001853_heart_inflammation1.12399718
72MP0000716_abnormal_immune_system1.12170986
73MP0003690_abnormal_glial_cell1.11326386
74MP0003183_abnormal_peptide_metabolism1.10349372
75MP0000858_altered_metastatic_potential1.10253931
76MP0002332_abnormal_exercise_endurance1.09975105
77MP0010678_abnormal_skin_adnexa1.09830415
78MP0003252_abnormal_bile_duct1.09645015
79MP0005397_hematopoietic_system_phenotyp1.09589645
80MP0001545_abnormal_hematopoietic_system1.09589645
81MP0005332_abnormal_amino_acid1.09235418
82MP0002877_abnormal_melanocyte_morpholog1.07063614
83MP0008874_decreased_physiological_sensi1.05879153
84MP0003186_abnormal_redox_activity1.05784802
85MP0000598_abnormal_liver_morphology1.03674981
86MP0001346_abnormal_lacrimal_gland1.03029554
87MP0003453_abnormal_keratinocyte_physiol1.01114126
88MP0005164_abnormal_response_to1.00917816
89MP0005671_abnormal_response_to1.00705724
90MP0003566_abnormal_cell_adhesion1.00304741
91MP0004185_abnormal_adipocyte_glucose1.00271808
92MP0004858_abnormal_nervous_system0.99559782
93MP0002722_abnormal_immune_system0.99209905
94MP0005501_abnormal_skin_physiology0.98861318
95MP0005666_abnormal_adipose_tissue0.97727842
96MP0002429_abnormal_blood_cell0.96486439
97MP0009764_decreased_sensitivity_to0.96175131
98MP0003567_abnormal_fetal_cardiomyocyte0.95916935
99MP0009672_abnormal_birth_weight0.95478578
100MP0004957_abnormal_blastocyst_morpholog0.95168205
101MP0005000_abnormal_immune_tolerance0.94924821
102MP0005375_adipose_tissue_phenotype0.93859088
103MP0005319_abnormal_enzyme/_coenzyme0.92354271
104MP0001730_embryonic_growth_arrest0.89814024
105MP0003077_abnormal_cell_cycle0.89810061
106MP0003879_abnormal_hair_cell0.89022274
107MP0000689_abnormal_spleen_morphology0.89006642
108MP0008260_abnormal_autophagy0.88362521
109MP0005025_abnormal_response_to0.87192958
110MP0005390_skeleton_phenotype0.87174214
111MP0002282_abnormal_trachea_morphology0.86107357
112MP0003172_abnormal_lysosome_physiology0.85257953
113MP0002419_abnormal_innate_immunity0.84473991
114MP0001666_abnormal_nutrient_absorption0.84371587
115MP0003221_abnormal_cardiomyocyte_apopto0.84220699
116MP0004808_abnormal_hematopoietic_stem0.84081524
117MP0010368_abnormal_lymphatic_system0.83951633
118MP0000465_gastrointestinal_hemorrhage0.83640596
119MP0000920_abnormal_myelination0.83341695
120MP0000249_abnormal_blood_vessel0.80706859
121MP0001672_abnormal_embryogenesis/_devel0.80393502
122MP0005380_embryogenesis_phenotype0.80393502
123MP0005165_increased_susceptibility_to0.78946810
124MP0003984_embryonic_growth_retardation0.77851059
125MP0002098_abnormal_vibrissa_morphology0.77773524
126MP0000750_abnormal_muscle_regeneration0.77403523
127MP0002132_abnormal_respiratory_system0.77395023
128MP0002118_abnormal_lipid_homeostasis0.77380467
129MP0002971_abnormal_brown_adipose0.77170541
130MP0005166_decreased_susceptibility_to0.77075647
131MP0002088_abnormal_embryonic_growth/wei0.76987045
132MP0005621_abnormal_cell_physiology0.76770634
133MP0003448_altered_tumor_morphology0.75978645
134MP0009931_abnormal_skin_appearance0.75909239
135MP0005464_abnormal_platelet_physiology0.74078659
136MP0003191_abnormal_cellular_cholesterol0.74027056
137MP0005451_abnormal_body_composition0.73833692
138MP0001697_abnormal_embryo_size0.73281324
139MP0005310_abnormal_salivary_gland0.72536133
140MP0000703_abnormal_thymus_morphology0.72348186
141MP0003011_delayed_dark_adaptation0.71619386
142MP0009053_abnormal_anal_canal0.69142617
143MP0001845_abnormal_inflammatory_respons0.68965878
144MP0003693_abnormal_embryo_hatching0.67322719
145MP0008469_abnormal_protein_level0.65594287
146MP0002060_abnormal_skin_morphology0.64892462
147MP0005023_abnormal_wound_healing0.64432252
148MP0009785_altered_susceptibility_to0.64315804
149MP0001216_abnormal_epidermal_layer0.64100555
150MP0000377_abnormal_hair_follicle0.63982742
151MP0006082_CNS_inflammation0.63975084
152MP0009763_increased_sensitivity_to0.63589926
153MP0005448_abnormal_energy_balance0.62101837
154MP0009643_abnormal_urine_homeostasis0.61670703
155MP0005187_abnormal_penis_morphology0.61268456

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.83987065
2Severe Myopia (HP:0011003)4.73537050
3Subacute progressive viral hepatitis (HP:0006572)4.45914702
4Toxemia of pregnancy (HP:0100603)4.24781114
5Increased nuchal translucency (HP:0010880)3.43626208
6Hepatocellular carcinoma (HP:0001402)3.29984617
7Spastic diplegia (HP:0001264)3.29823802
8Abnormality of the umbilical cord (HP:0010881)3.28644988
9Abnormality of glycolipid metabolism (HP:0010969)3.17412161
10Abnormality of liposaccharide metabolism (HP:0010968)3.17412161
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.17412161
12Recurrent bacterial skin infections (HP:0005406)3.03820900
13Round ear (HP:0100830)3.01578144
14Recurrent abscess formation (HP:0002722)3.00648819
15Xanthomatosis (HP:0000991)2.98778700
16Myocardial infarction (HP:0001658)2.98778149
17Myositis (HP:0100614)2.94353407
18Micronodular cirrhosis (HP:0001413)2.91615999
19Orchitis (HP:0100796)2.89388479
20Absent radius (HP:0003974)2.88427589
21Abnormal umbilical cord blood vessels (HP:0011403)2.82391093
22Single umbilical artery (HP:0001195)2.82391093
23Abnormality of the fetal cardiovascular system (HP:0010948)2.82391093
24Breast carcinoma (HP:0003002)2.78682145
25Tetraparesis (HP:0002273)2.77832192
26Increased IgE level (HP:0003212)2.74022420
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72906178
28Prolonged bleeding time (HP:0003010)2.72721965
29Amyloidosis (HP:0011034)2.71788275
30Volvulus (HP:0002580)2.71317444
31Hyperacusis (HP:0010780)2.70131911
32Poikilocytosis (HP:0004447)2.67303830
33Cellulitis (HP:0100658)2.64416507
34Abnormality of pyrimidine metabolism (HP:0004353)2.64026595
35Elevated erythrocyte sedimentation rate (HP:0003565)2.62592569
36Deep venous thrombosis (HP:0002625)2.59979711
37Distal lower limb muscle weakness (HP:0009053)2.58658195
38Eczematoid dermatitis (HP:0000976)2.56778774
39Absent forearm bone (HP:0003953)2.56643771
40Aplasia involving forearm bones (HP:0009822)2.56643771
41Distal lower limb amyotrophy (HP:0008944)2.54901131
42Neurofibrillary tangles (HP:0002185)2.52148979
43Cone-rod dystrophy (HP:0000548)2.50920250
44Abnormality of abdominal situs (HP:0011620)2.49661071
45Abdominal situs inversus (HP:0003363)2.49661071
46Loss of speech (HP:0002371)2.49384565
47Nasal polyposis (HP:0100582)2.48482330
48Gastrointestinal infarctions (HP:0005244)2.48472115
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47714805
50Purpura (HP:0000979)2.47621808
51Nausea (HP:0002018)2.45153117
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44119124
53Increased connective tissue (HP:0009025)2.42187826
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.39524571
55Cerebral inclusion bodies (HP:0100314)2.39492238
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.39421493
57Mediastinal lymphadenopathy (HP:0100721)2.37916180
58Optic neuritis (HP:0100653)2.35754647
59Retrobulbar optic neuritis (HP:0100654)2.35754647
60Hyperglycinemia (HP:0002154)2.35495998
61Polycythemia (HP:0001901)2.34972196
62Absent thumb (HP:0009777)2.34750396
63Segmental peripheral demyelination/remyelination (HP:0003481)2.34291494
64Peripheral hypomyelination (HP:0007182)2.33787211
65Bile duct proliferation (HP:0001408)2.32917646
66Abnormal biliary tract physiology (HP:0012439)2.32917646
67Gingivitis (HP:0000230)2.32308271
68Germ cell neoplasia (HP:0100728)2.31602421
69Abnormality of macrophages (HP:0004311)2.31329204
70Urticaria (HP:0001025)2.30028312
71Dysostosis multiplex (HP:0000943)2.29615468
72Petechiae (HP:0000967)2.29504512
73Vertebral compression fractures (HP:0002953)2.29309963
74Muscle fiber splitting (HP:0003555)2.29083430
75Epistaxis (HP:0000421)2.25326331
76Stomatitis (HP:0010280)2.25159775
77Abnormality of the nasal mucosa (HP:0000433)2.24862861
78Overriding aorta (HP:0002623)2.24814671
79Meckel diverticulum (HP:0002245)2.24040775
80Aqueductal stenosis (HP:0002410)2.23424389
81Gingival bleeding (HP:0000225)2.22970712
82Obstructive lung disease (HP:0006536)2.21404700
83Chronic obstructive pulmonary disease (HP:0006510)2.21404700
84Autoimmune thrombocytopenia (HP:0001973)2.20865012
85Interstitial pulmonary disease (HP:0006530)2.19840317
86Intrahepatic cholestasis (HP:0001406)2.19329175
87Hyperlipoproteinemia (HP:0010980)2.18637418
88Abnormality of the common coagulation pathway (HP:0010990)2.17492000
89Abnormality of skeletal muscle fiber size (HP:0012084)2.17266265
90Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16236920
91Natal tooth (HP:0000695)2.16148045
92Spontaneous hematomas (HP:0007420)2.15692251
93Abnormality of the carotid arteries (HP:0005344)2.15172569
94Impulsivity (HP:0100710)2.13785964
95Acanthocytosis (HP:0001927)2.13004435
96Premature rupture of membranes (HP:0001788)2.12413106
97Hyperglycinuria (HP:0003108)2.12390252
98Hypochromic anemia (HP:0001931)2.11892748
99Ureteral duplication (HP:0000073)2.10677598
100Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09527563
101Neuronal loss in central nervous system (HP:0002529)2.09227045
102Abnormality of the distal phalanges of the toes (HP:0010182)2.08860362
103Viral hepatitis (HP:0006562)2.08732885
104Insomnia (HP:0100785)2.08690217
105Large earlobe (HP:0009748)2.08281890
106Abnormality of the ileum (HP:0001549)2.07379162
107Abnormality of fatty-acid metabolism (HP:0004359)2.07001127
108Striae distensae (HP:0001065)2.06970975
109Exercise-induced myalgia (HP:0003738)2.06406077
110Increased cerebral lipofuscin (HP:0011813)2.06326066
111Hyperglycemia (HP:0003074)2.05355001
112Thick nail (HP:0001805)2.05222905
113Hypoalphalipoproteinemia (HP:0003233)2.05127631
114Increased serum ferritin (HP:0003281)2.04785250
115Leiomyosarcoma (HP:0100243)2.04625484
116Uterine leiomyosarcoma (HP:0002891)2.04625484
117Hypobetalipoproteinemia (HP:0003563)2.03907971
118Renovascular hypertension (HP:0100817)2.03718802
119Elfin facies (HP:0004428)2.03204415
120Slow saccadic eye movements (HP:0000514)2.01506137
121Malignant gastrointestinal tract tumors (HP:0006749)2.00385552
122Gastrointestinal carcinoma (HP:0002672)2.00385552
123Complement deficiency (HP:0004431)2.00057799
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.99420466
125Obstructive sleep apnea (HP:0002870)1.99027256
126Increased variability in muscle fiber diameter (HP:0003557)1.98056363
127Vasculitis (HP:0002633)1.96629962
128Low anterior hairline (HP:0000294)1.95782499
129Hypolipoproteinemia (HP:0010981)1.95655304
130Abnormality of nail color (HP:0100643)1.95614537
131Reticulocytosis (HP:0001923)1.94542343
132Shallow orbits (HP:0000586)1.94398802
133Abnormality of nucleobase metabolism (HP:0010932)1.94308827
134Abnormality of chromosome stability (HP:0003220)1.93570274
135Systemic lupus erythematosus (HP:0002725)1.93416284
136Submucous cleft hard palate (HP:0000176)1.93052873
137Pustule (HP:0200039)1.92547038
138Decreased motor nerve conduction velocity (HP:0003431)1.91813578
139Asymmetric septal hypertrophy (HP:0001670)1.91316476
140Supranuclear gaze palsy (HP:0000605)1.91132132
141Abnormal platelet volume (HP:0011876)1.90802493
142Keratoconjunctivitis sicca (HP:0001097)1.87938904
143Facial hemangioma (HP:0000329)1.87920423
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87252605
145Osteomyelitis (HP:0002754)1.87137265
146Peritonitis (HP:0002586)1.85269391
147Hypochromic microcytic anemia (HP:0004840)1.85171455
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84758135
149Fatigue (HP:0012378)1.84127896
150Polygenic inheritance (HP:0010982)1.83624936
151Chest pain (HP:0100749)1.83549790
152Recurrent skin infections (HP:0001581)1.83395879
153Difficulty climbing stairs (HP:0003551)1.83317263
154Neoplasm of the liver (HP:0002896)1.83200354
155Abnormality of transition element cation homeostasis (HP:0011030)1.81980015
156Axonal loss (HP:0003447)1.81004661
157Abnormality of iron homeostasis (HP:0011031)1.80999793
158Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80246335
159Hypertriglyceridemia (HP:0002155)1.79492057
160Prominent nose (HP:0000448)1.78293932
161Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77861540
162Abnormality of polysaccharide metabolism (HP:0011012)1.77861540
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77861540
164Meningitis (HP:0001287)1.77718304
165Proximal placement of thumb (HP:0009623)1.77122403
166Rapidly progressive (HP:0003678)1.76836992
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76530505
168Episodic fever (HP:0001954)1.76260626
169Abnormality of glycine metabolism (HP:0010895)1.76247949
170Abnormality of serine family amino acid metabolism (HP:0010894)1.76247949
171Increased neuronal autofluorescent lipopigment (HP:0002074)1.75841465
172Microcytic anemia (HP:0001935)1.75576259
173Bladder carcinoma (HP:0002862)1.74690062
174Diminished motivation (HP:0000745)1.74149213
175Ragged-red muscle fibers (HP:0003200)1.73803091
176Lower limb amyotrophy (HP:0007210)1.73089773
177Apathy (HP:0000741)1.72687707
178Foot dorsiflexor weakness (HP:0009027)1.71032401
179Onion bulb formation (HP:0003383)1.70576405
180Hepatosplenomegaly (HP:0001433)1.70487675
181Achilles tendon contracture (HP:0001771)1.69770883
182Impaired platelet aggregation (HP:0003540)1.68197131
183Abnormal platelet function (HP:0011869)1.68197131
184Gastrointestinal inflammation (HP:0004386)1.67821977
185Mucopolysacchariduria (HP:0008155)1.67555425
186Urinary glycosaminoglycan excretion (HP:0003541)1.67555425
187Cholelithiasis (HP:0001081)1.66464990
188Abnormal blistering of the skin (HP:0008066)1.65941304
189Osteolytic defects of the hand bones (HP:0009699)1.65130577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.95946891
2STK38L4.69539616
3PRPF4B3.74833371
4NEK23.31745196
5PAK42.84258537
6RIPK42.62983455
7PTK62.58765088
8MAP2K32.52546188
9BCKDK2.51628197
10NTRK22.43933538
11IRAK32.29381402
12TAOK22.23186414
13CDK62.20672988
14ERN12.19574658
15MAP3K112.17239766
16TAOK12.15525582
17STK382.04812954
18TRIB32.03973064
19SRPK11.94488712
20EPHB11.87361616
21TBK11.76770588
22TTK1.74190157
23FER1.67320061
24RPS6KA41.64309732
25PDK31.61226723
26PDK41.61226723
27IRAK41.57016992
28STK31.50866677
29BLK1.49136820
30CSK1.46877316
31EIF2AK11.40289119
32ARAF1.36309592
33MAP3K131.35409673
34CHUK1.31505388
35MELK1.30473414
36STK101.30309378
37TYK21.30274279
38MARK21.29940165
39MAP3K101.29001579
40SIK11.28991604
41SIK31.26703346
42ERBB21.26291118
43GRK61.24404751
44CSNK1G31.21946069
45LATS11.20376101
46FGFR41.18907026
47CSNK1A1L1.18592348
48MAP4K11.10627751
49MAP3K61.08448739
50FES1.07255081
51BUB11.06841669
52PRKD21.06663638
53FGR1.03945815
54TNK21.02546870
55DYRK1B1.02251155
56SIK20.99914950
57HCK0.97602217
58NEK90.97408673
59BMX0.96782781
60PLK40.96078281
61PKN20.94514559
62TESK10.94294066
63MOS0.93332819
64SMG10.93234633
65IRAK20.92317670
66JAK20.89556901
67CSNK1G20.89218346
68JAK10.88672617
69TAOK30.87486724
70PDK20.87174666
71SGK30.87139137
72ICK0.85379137
73CAMK1D0.84013442
74CSNK1G10.83709589
75CDK120.83466461
76MAPK120.80812369
77PDPK10.79952435
78TTN0.79309717
79LRRK20.77398424
80CDC42BPA0.76444178
81BRAF0.75928261
82MATK0.74333050
83KSR10.73970823
84ACVR1B0.73959776
85IKBKE0.73744716
86AKT20.73254141
87WNK10.71723520
88MST1R0.71211845
89BTK0.70772979
90SYK0.69675357
91MAPKAPK30.69633594
92PIK3CG0.67194194
93EPHA30.66604418
94PIM10.66414924
95TESK20.66087115
96BRSK20.64940573
97RPS6KA20.64771560
98MAP3K20.64499870
99DYRK30.63732277
100DDR20.63686668
101PBK0.62910590
102MAP3K30.62657743
103MAPK70.60817607
104RPS6KL10.59909628
105RPS6KC10.59909628
106MARK30.59306589
107MAP3K50.59254859
108CAMK1G0.59204103
109HIPK20.58678960
110PDGFRA0.57429110
111PDK10.57408896
112IKBKB0.56319625
113PLK10.55518821
114JAK30.54938265
115WEE10.54508447
116PDGFRB0.53944155
117MTOR0.53680844
118AURKB0.53608204
119ABL20.53185031
120MAP3K80.53055616
121EPHA20.52765226
122ERBB40.52593200
123RAF10.52386203
124PRKAA20.52184862
125CAMKK10.51033513
126MAP2K40.48931454
127IRAK10.48324950
128CSF1R0.48319244
129STK40.47037370
130RET0.46925926
131KSR20.46459547
132STK240.46286544
133RIPK10.46284631
134YES10.46085767
135SGK20.45884521
136SGK2230.44963272
137SGK4940.44963272
138PIM20.43583059
139LATS20.43054217
140FYN0.42637825
141LYN0.41900132
142TGFBR20.41808054
143PRKAA10.41559929
144GSK3A0.41137068
145PRKD10.40703557
146MAPK110.40203230
147EGFR0.37748854
148ATM0.36860176
149BRSK10.36717064
150TLK10.36664937
151ZAP700.35609139
152PTK20.34925573
153ATR0.32076442
154CDK70.31695496
155KDR0.31085236
156MAP3K140.29494841
157MAP3K10.29127905
158STK110.28918619

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002203.37925720
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.60871807
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.20513839
4Caffeine metabolism_Homo sapiens_hsa002322.08035402
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02173309
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01105484
7Pentose phosphate pathway_Homo sapiens_hsa000301.95273718
8Other glycan degradation_Homo sapiens_hsa005111.93805440
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93547546
10Biosynthesis of amino acids_Homo sapiens_hsa012301.82349108
11Nitrogen metabolism_Homo sapiens_hsa009101.81188868
12Vitamin B6 metabolism_Homo sapiens_hsa007501.78331764
13Staphylococcus aureus infection_Homo sapiens_hsa051501.76799870
14B cell receptor signaling pathway_Homo sapiens_hsa046621.76069400
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69550216
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65810391
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.64085409
18Fatty acid degradation_Homo sapiens_hsa000711.62909580
19Selenocompound metabolism_Homo sapiens_hsa004501.61019421
20Carbon metabolism_Homo sapiens_hsa012001.57393140
21Complement and coagulation cascades_Homo sapiens_hsa046101.56765793
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53418714
23PPAR signaling pathway_Homo sapiens_hsa033201.48588093
24Pancreatic cancer_Homo sapiens_hsa052121.45601902
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44987533
26Shigellosis_Homo sapiens_hsa051311.44415334
27Non-small cell lung cancer_Homo sapiens_hsa052231.41193593
28Salmonella infection_Homo sapiens_hsa051321.38185673
29Legionellosis_Homo sapiens_hsa051341.36908988
30Hepatitis C_Homo sapiens_hsa051601.35863752
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34501109
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31843333
33Fat digestion and absorption_Homo sapiens_hsa049751.30484854
34VEGF signaling pathway_Homo sapiens_hsa043701.27803434
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27640172
36Leishmaniasis_Homo sapiens_hsa051401.27323557
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25032195
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.22458577
39Peroxisome_Homo sapiens_hsa041461.22126485
40Renal cell carcinoma_Homo sapiens_hsa052111.21255246
41Chemokine signaling pathway_Homo sapiens_hsa040621.19487738
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.19023151
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18759349
44Hepatitis B_Homo sapiens_hsa051611.16748942
45Endocytosis_Homo sapiens_hsa041441.16419185
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15976338
47Tryptophan metabolism_Homo sapiens_hsa003801.14788469
48Prion diseases_Homo sapiens_hsa050201.14068191
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13915091
50Lysine degradation_Homo sapiens_hsa003101.13730004
51Measles_Homo sapiens_hsa051621.12587169
52Phagosome_Homo sapiens_hsa041451.12148113
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.11719838
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11287724
55Notch signaling pathway_Homo sapiens_hsa043301.09777685
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09703033
57T cell receptor signaling pathway_Homo sapiens_hsa046601.08316267
58Propanoate metabolism_Homo sapiens_hsa006401.07968365
59Insulin resistance_Homo sapiens_hsa049311.07923102
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.06309631
61Fatty acid metabolism_Homo sapiens_hsa012121.06104205
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05736249
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04931298
64One carbon pool by folate_Homo sapiens_hsa006701.04647124
65Adipocytokine signaling pathway_Homo sapiens_hsa049201.03757500
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01310771
67Cell cycle_Homo sapiens_hsa041101.00961737
68Thyroid cancer_Homo sapiens_hsa052161.00725699
69Platelet activation_Homo sapiens_hsa046110.98316854
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.96325367
71GnRH signaling pathway_Homo sapiens_hsa049120.93469040
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.91156798
73Malaria_Homo sapiens_hsa051440.90350743
74Lysosome_Homo sapiens_hsa041420.89744536
75ErbB signaling pathway_Homo sapiens_hsa040120.87937228
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.87072943
77Insulin signaling pathway_Homo sapiens_hsa049100.87012222
78Hematopoietic cell lineage_Homo sapiens_hsa046400.86447086
79Prolactin signaling pathway_Homo sapiens_hsa049170.86101052
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.85607194
81TGF-beta signaling pathway_Homo sapiens_hsa043500.84561603
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82663727
83African trypanosomiasis_Homo sapiens_hsa051430.82340473
84Viral myocarditis_Homo sapiens_hsa054160.82302110
85Sulfur relay system_Homo sapiens_hsa041220.82105225
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81480481
87mTOR signaling pathway_Homo sapiens_hsa041500.80638568
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79413033
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78646019
90p53 signaling pathway_Homo sapiens_hsa041150.78491324
91Phenylalanine metabolism_Homo sapiens_hsa003600.78386510
92Starch and sucrose metabolism_Homo sapiens_hsa005000.77645205
93Osteoclast differentiation_Homo sapiens_hsa043800.76448349
94Retinol metabolism_Homo sapiens_hsa008300.76282071
95Glioma_Homo sapiens_hsa052140.75966491
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.75841364
97HIF-1 signaling pathway_Homo sapiens_hsa040660.75740345
98Fanconi anemia pathway_Homo sapiens_hsa034600.75177977
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74734159
100Choline metabolism in cancer_Homo sapiens_hsa052310.74634901
101Fructose and mannose metabolism_Homo sapiens_hsa000510.73988914
102Vitamin digestion and absorption_Homo sapiens_hsa049770.73584682
103Viral carcinogenesis_Homo sapiens_hsa052030.73191968
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71464967
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70500236
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69938794
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69909864
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69814937
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.68873065
110Apoptosis_Homo sapiens_hsa042100.68657165
111AMPK signaling pathway_Homo sapiens_hsa041520.68291256
112beta-Alanine metabolism_Homo sapiens_hsa004100.68138898
113Pyruvate metabolism_Homo sapiens_hsa006200.67719805
114Tuberculosis_Homo sapiens_hsa051520.67536022
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67529905
116Folate biosynthesis_Homo sapiens_hsa007900.66159375
117Herpes simplex infection_Homo sapiens_hsa051680.65508775
118Small cell lung cancer_Homo sapiens_hsa052220.65085483
119Base excision repair_Homo sapiens_hsa034100.64580660
120Acute myeloid leukemia_Homo sapiens_hsa052210.64482046
121Estrogen signaling pathway_Homo sapiens_hsa049150.63447956
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63328496
123Proteoglycans in cancer_Homo sapiens_hsa052050.63196962
124MicroRNAs in cancer_Homo sapiens_hsa052060.63171833
125Endometrial cancer_Homo sapiens_hsa052130.62799880
126Focal adhesion_Homo sapiens_hsa045100.62697755
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.62420659
128TNF signaling pathway_Homo sapiens_hsa046680.62367277
129Influenza A_Homo sapiens_hsa051640.61786672
130Long-term potentiation_Homo sapiens_hsa047200.61561516
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61396068
132Rheumatoid arthritis_Homo sapiens_hsa053230.61114346
133Inositol phosphate metabolism_Homo sapiens_hsa005620.60037957
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59893460
135MAPK signaling pathway_Homo sapiens_hsa040100.58781938
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57980012
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57538314
138Vibrio cholerae infection_Homo sapiens_hsa051100.57340345
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57253546
140Galactose metabolism_Homo sapiens_hsa000520.56258718
141Bladder cancer_Homo sapiens_hsa052190.55542514
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54562057
143Bile secretion_Homo sapiens_hsa049760.53993389
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52849403
145Butanoate metabolism_Homo sapiens_hsa006500.52809158
146Pertussis_Homo sapiens_hsa051330.52219592
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51298184
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51190970
149Oocyte meiosis_Homo sapiens_hsa041140.49077842
150HTLV-I infection_Homo sapiens_hsa051660.48634745
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48484996
152Amoebiasis_Homo sapiens_hsa051460.48391082
153Prostate cancer_Homo sapiens_hsa052150.47230393
154Chronic myeloid leukemia_Homo sapiens_hsa052200.46950924
155Adherens junction_Homo sapiens_hsa045200.46557365
156Histidine metabolism_Homo sapiens_hsa003400.46013952
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45814813
158Epstein-Barr virus infection_Homo sapiens_hsa051690.45636444
159Toxoplasmosis_Homo sapiens_hsa051450.45131734
160Antigen processing and presentation_Homo sapiens_hsa046120.44487160
161FoxO signaling pathway_Homo sapiens_hsa040680.44398970

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