UBA52P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)5.96982374
2behavioral response to nicotine (GO:0035095)5.95813782
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.88397811
4ATP synthesis coupled proton transport (GO:0015986)5.59027364
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.59027364
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.49781426
7DNA deamination (GO:0045006)5.15189072
8regulation of immunoglobulin secretion (GO:0051023)4.95196735
9regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.86258102
10regulation of regulatory T cell differentiation (GO:0045589)4.60877005
11sequestering of actin monomers (GO:0042989)4.40408641
12regulation of isotype switching to IgG isotypes (GO:0048302)4.35438294
13regulation of B cell apoptotic process (GO:0002902)4.06371942
14ribosomal small subunit assembly (GO:0000028)3.95174266
15positive regulation of prostaglandin secretion (GO:0032308)3.56124263
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51350977
17protein neddylation (GO:0045116)3.50214823
18pseudouridine synthesis (GO:0001522)3.48625468
19peptidyl-histidine modification (GO:0018202)3.44503077
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38472953
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38472953
22NIK/NF-kappaB signaling (GO:0038061)3.34796892
23respiratory electron transport chain (GO:0022904)3.33703504
24electron transport chain (GO:0022900)3.33087551
25somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.27843999
26isotype switching (GO:0045190)3.27843999
27somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.27843999
28cytidine deamination (GO:0009972)3.26899238
29cytidine metabolic process (GO:0046087)3.26899238
30cytidine catabolic process (GO:0006216)3.26899238
31protein complex biogenesis (GO:0070271)3.24902859
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23631895
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.23631895
34NADH dehydrogenase complex assembly (GO:0010257)3.23631895
35regulation of memory T cell differentiation (GO:0043380)3.21853489
36regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.17497649
37myoblast migration (GO:0051451)3.13067078
38positive regulation of interleukin-17 production (GO:0032740)3.13066792
39regulation of prostaglandin secretion (GO:0032306)3.11305633
40negative regulation of telomere maintenance (GO:0032205)3.07740460
41ATP biosynthetic process (GO:0006754)3.04696070
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04485262
43regulation of T cell mediated cytotoxicity (GO:0001914)3.01994374
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99859845
45L-fucose catabolic process (GO:0042355)2.95111027
46fucose catabolic process (GO:0019317)2.95111027
47L-fucose metabolic process (GO:0042354)2.95111027
48negative regulation of mast cell activation (GO:0033004)2.93624335
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93232987
50interferon-gamma production (GO:0032609)2.91916606
51embryonic hemopoiesis (GO:0035162)2.90222448
52purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.85365519
53mitochondrial respiratory chain complex assembly (GO:0033108)2.85252340
54GTP biosynthetic process (GO:0006183)2.84545132
55regulation of response to tumor cell (GO:0002834)2.84164557
56positive regulation of response to tumor cell (GO:0002836)2.84164557
57positive regulation of immune response to tumor cell (GO:0002839)2.84164557
58regulation of immune response to tumor cell (GO:0002837)2.84164557
59indole-containing compound catabolic process (GO:0042436)2.83912866
60indolalkylamine catabolic process (GO:0046218)2.83912866
61tryptophan catabolic process (GO:0006569)2.83912866
62regulation of T cell migration (GO:2000404)2.83802092
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82734863
64drug catabolic process (GO:0042737)2.82197715
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80749615
66positive regulation of T-helper 1 type immune response (GO:0002827)2.80316490
67regulation of hypersensitivity (GO:0002883)2.74566750
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.74214711
69termination of RNA polymerase III transcription (GO:0006386)2.74214711
70positive regulation of fatty acid transport (GO:2000193)2.73979747
71neuron fate determination (GO:0048664)2.72187711
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71815474
73pyrimidine ribonucleoside catabolic process (GO:0046133)2.67610006
74signal peptide processing (GO:0006465)2.66080778
75positive regulation of T cell migration (GO:2000406)2.63822337
76establishment of protein localization to mitochondrial membrane (GO:0090151)2.63438516
77necroptotic process (GO:0070266)2.61852471
78positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.60763964
79negative T cell selection (GO:0043383)2.59368750
80retinal cone cell development (GO:0046549)2.57574640
81regulation of cell killing (GO:0031341)2.56292775
82negative regulation of macrophage differentiation (GO:0045650)2.55367636
83regulation of leukocyte mediated cytotoxicity (GO:0001910)2.54998779
84positive regulation of T cell mediated cytotoxicity (GO:0001916)2.51063515
85hydrogen ion transmembrane transport (GO:1902600)2.50199308
86chaperone-mediated protein transport (GO:0072321)2.50059647
87synaptic transmission, cholinergic (GO:0007271)2.50001688
88negative thymic T cell selection (GO:0045060)2.49419722
89neural tube formation (GO:0001841)2.47595360
90water-soluble vitamin biosynthetic process (GO:0042364)2.47471962
91positive regulation of DNA recombination (GO:0045911)2.44427175
92mast cell degranulation (GO:0043303)2.43770554
93mast cell activation involved in immune response (GO:0002279)2.43770554
94positive regulation of respiratory burst (GO:0060267)2.43593915
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.43123182
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40792300
97positive regulation of isotype switching (GO:0045830)2.39890719
98kidney morphogenesis (GO:0060993)2.38888543
99positive regulation of activated T cell proliferation (GO:0042104)2.36501116
100regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.35837042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.28230237
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.47376662
3ZNF274_21170338_ChIP-Seq_K562_Hela3.32782186
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07538199
5VDR_22108803_ChIP-Seq_LS180_Human2.81995039
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.81775435
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73425302
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70386796
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51610288
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.42493949
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42349834
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.26079046
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15583560
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10434179
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03845469
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01676559
17VDR_23849224_ChIP-Seq_CD4+_Human1.98586385
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.98292868
19ELK1_19687146_ChIP-ChIP_HELA_Human1.96082420
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92846337
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91706299
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.91169079
23TAF15_26573619_Chip-Seq_HEK293_Human1.79452743
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78027810
25TP53_22573176_ChIP-Seq_HFKS_Human1.77758902
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75498545
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67180543
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60276174
29EWS_26573619_Chip-Seq_HEK293_Human1.58512700
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55779250
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.51976750
32FOXP3_21729870_ChIP-Seq_TREG_Human1.48606953
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48323431
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47440335
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46699270
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.46401417
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.44759275
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.41132161
39MYC_18940864_ChIP-ChIP_HL60_Human1.40432302
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.37022141
41NCOR_22424771_ChIP-Seq_293T_Human1.32264891
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31848669
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29368185
44ER_23166858_ChIP-Seq_MCF-7_Human1.28687518
45GATA3_26560356_Chip-Seq_TH2_Human1.27851219
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27285069
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27204567
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26402158
49ETV1_20927104_ChIP-Seq_GIST48_Human1.25511565
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24898287
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22338035
52AR_20517297_ChIP-Seq_VCAP_Human1.20106905
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18887228
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18382776
55RBPJ_21746931_ChIP-Seq_IB4_Human1.14959680
56NANOG_20526341_ChIP-Seq_ESCs_Human1.14197752
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14138131
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.14138131
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13878758
60EZH2_22144423_ChIP-Seq_EOC_Human1.13664515
61FUS_26573619_Chip-Seq_HEK293_Human1.12643348
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11642177
63BCAT_22108803_ChIP-Seq_LS180_Human1.10756837
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.10230686
65PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06435055
66GBX2_23144817_ChIP-Seq_PC3_Human1.06206888
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05486884
68CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05064728
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04619603
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03987570
71HOXB7_26014856_ChIP-Seq_BT474_Human1.03856603
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.02347411
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02000565
74TCF4_22108803_ChIP-Seq_LS180_Human1.01258328
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01044296
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99273720
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98765002
78P300_19829295_ChIP-Seq_ESCs_Human0.97905690
79SOX2_19829295_ChIP-Seq_ESCs_Human0.97546229
80NANOG_19829295_ChIP-Seq_ESCs_Human0.97546229
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97202708
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97151549
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.95998944
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94832200
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94651626
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94105336
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93946886
88STAT3_18555785_Chip-Seq_ESCs_Mouse0.93463151
89ERA_21632823_ChIP-Seq_H3396_Human0.92649625
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91962779
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91519474
92TAF2_19829295_ChIP-Seq_ESCs_Human0.89774198
93P53_21459846_ChIP-Seq_SAOS-2_Human0.89442283
94KLF4_18555785_Chip-Seq_ESCs_Mouse0.88931321
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.88855476
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88107970
97PHF8_20622853_ChIP-Seq_HELA_Human0.87927717
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87271279
99SOX2_18555785_Chip-Seq_ESCs_Mouse0.84888573
100TTF2_22483619_ChIP-Seq_HELA_Human0.84792591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.88243125
2MP0001835_abnormal_antigen_presentation3.67921706
3MP0000685_abnormal_immune_system2.64519467
4MP0002102_abnormal_ear_morphology2.52286412
5MP0008875_abnormal_xenobiotic_pharmacok2.34935119
6MP0005671_abnormal_response_to2.31131556
7MP0000372_irregular_coat_pigmentation2.30571377
8MP0004043_abnormal_pH_regulation2.20662027
9MP0002138_abnormal_hepatobiliary_system2.13440598
10MP0002638_abnormal_pupillary_reflex2.05648051
11MP0008877_abnormal_DNA_methylation2.03472578
12MP0003283_abnormal_digestive_organ2.03218677
13MP0004145_abnormal_muscle_electrophysio2.03064481
14MP0003195_calcinosis1.98495946
15MP0004885_abnormal_endolymph1.92599494
16MP0000604_amyloidosis1.88930100
17MP0002148_abnormal_hypersensitivity_rea1.88112282
18MP0005084_abnormal_gallbladder_morpholo1.82813893
19MP0006292_abnormal_olfactory_placode1.82019686
20MP0002876_abnormal_thyroid_physiology1.75666532
21MP0002163_abnormal_gland_morphology1.63033495
22MP0000465_gastrointestinal_hemorrhage1.62170294
23MP0006276_abnormal_autonomic_nervous1.61455252
24MP0003787_abnormal_imprinting1.59853777
25MP0001790_abnormal_immune_system1.59021922
26MP0005387_immune_system_phenotype1.59021922
27MP0009333_abnormal_splenocyte_physiolog1.57987793
28MP0009379_abnormal_foot_pigmentation1.57201162
29MP0005075_abnormal_melanosome_morpholog1.52750898
30MP0004142_abnormal_muscle_tone1.51439749
31MP0001800_abnormal_humoral_immune1.50556051
32MP0002653_abnormal_ependyma_morphology1.48287333
33MP0005551_abnormal_eye_electrophysiolog1.45597587
34MP0003806_abnormal_nucleotide_metabolis1.44452767
35MP0010386_abnormal_urinary_bladder1.42517999
36MP0001984_abnormal_olfaction1.42489033
37MP0005083_abnormal_biliary_tract1.39722047
38MP0005000_abnormal_immune_tolerance1.38212933
39MP0006072_abnormal_retinal_apoptosis1.35044368
40MP0003300_gastrointestinal_ulcer1.32038831
41MP0004147_increased_porphyrin_level1.31967002
42MP0003718_maternal_effect1.31409459
43MP0000538_abnormal_urinary_bladder1.27588605
44MP0003011_delayed_dark_adaptation1.26953561
45MP0002006_tumorigenesis1.26716319
46MP0002405_respiratory_system_inflammati1.25729756
47MP0005646_abnormal_pituitary_gland1.22905478
48MP0002234_abnormal_pharynx_morphology1.22834620
49MP0001853_heart_inflammation1.20363304
50MP0002723_abnormal_immune_serum1.20102539
51MP0002166_altered_tumor_susceptibility1.19668216
52MP0003786_premature_aging1.17791942
53MP0003252_abnormal_bile_duct1.16104081
54MP0008961_abnormal_basal_metabolism1.11542878
55MP0005645_abnormal_hypothalamus_physiol1.10651621
56MP0001968_abnormal_touch/_nociception1.07928205
57MP0003329_amyloid_beta_deposits1.07889370
58MP0005174_abnormal_tail_pigmentation1.07865155
59MP0005253_abnormal_eye_physiology1.05444369
60MP0008872_abnormal_physiological_respon1.04083766
61MP0003646_muscle_fatigue1.02940108
62MP0001845_abnormal_inflammatory_respons1.01190087
63MP0002938_white_spotting1.00377965
64MP0002452_abnormal_antigen_presenting0.99809258
65MP0001756_abnormal_urination0.99477962
66MP0002420_abnormal_adaptive_immunity0.99457954
67MP0010155_abnormal_intestine_physiology0.99239909
68MP0002139_abnormal_hepatobiliary_system0.98579546
69MP0001819_abnormal_immune_cell0.97578044
70MP0003866_abnormal_defecation0.96895999
71MP0006082_CNS_inflammation0.96620460
72MP0008789_abnormal_olfactory_epithelium0.95129824
73MP0005389_reproductive_system_phenotype0.94916740
74MP0002272_abnormal_nervous_system0.93338885
75MP0001905_abnormal_dopamine_level0.90407380
76MP0004742_abnormal_vestibular_system0.89719792
77MP0001873_stomach_inflammation0.89522730
78MP0009745_abnormal_behavioral_response0.88948211
79MP0005025_abnormal_response_to0.88275490
80MP0002160_abnormal_reproductive_system0.88101444
81MP0009785_altered_susceptibility_to0.87086070
82MP0004381_abnormal_hair_follicle0.86283854
83MP0002736_abnormal_nociception_after0.85902879
84MP0009046_muscle_twitch0.85211237
85MP0000689_abnormal_spleen_morphology0.84991164
86MP0002693_abnormal_pancreas_physiology0.84256453
87MP0005377_hearing/vestibular/ear_phenot0.84183030
88MP0003878_abnormal_ear_physiology0.84183030
89MP0003724_increased_susceptibility_to0.83925913
90MP0005085_abnormal_gallbladder_physiolo0.83316639
91MP0005332_abnormal_amino_acid0.82131185
92MP0000569_abnormal_digit_pigmentation0.81953789
93MP0001970_abnormal_pain_threshold0.81850750
94MP0001661_extended_life_span0.81470885
95MP0003638_abnormal_response/metabolism_0.81150731
96MP0002733_abnormal_thermal_nociception0.78132372
97MP0009764_decreased_sensitivity_to0.76528318
98MP0005379_endocrine/exocrine_gland_phen0.75092674
99MP0002398_abnormal_bone_marrow0.74224235
100MP0002837_dystrophic_cardiac_calcinosis0.74078716

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.10193988
23-Methylglutaconic aciduria (HP:0003535)4.44405424
3Generalized aminoaciduria (HP:0002909)4.41875594
4Congenital stationary night blindness (HP:0007642)4.32287198
5Congenital, generalized hypertrichosis (HP:0004540)3.72769549
6IgG deficiency (HP:0004315)3.69998075
7Increased IgM level (HP:0003496)3.69949841
8Abnormality of the renal cortex (HP:0011035)3.30757834
9Renal cortical cysts (HP:0000803)3.21949305
10Acute necrotizing encephalopathy (HP:0006965)3.18731371
11Autoimmune thrombocytopenia (HP:0001973)3.13047464
12Hepatic necrosis (HP:0002605)3.12835797
13Mitochondrial inheritance (HP:0001427)3.09131560
14Lipid accumulation in hepatocytes (HP:0006561)3.08003477
15Pancreatic cysts (HP:0001737)3.07023224
16Nephronophthisis (HP:0000090)3.04805931
17Reduced antithrombin III activity (HP:0001976)3.04225240
18Increased hepatocellular lipid droplets (HP:0006565)3.02132970
19Increased CSF lactate (HP:0002490)2.99782474
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98235303
21Abnormality of alanine metabolism (HP:0010916)2.98235303
22Hyperalaninemia (HP:0003348)2.98235303
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.97362853
24Severe combined immunodeficiency (HP:0004430)2.85449932
25Thyroiditis (HP:0100646)2.81158899
26Abnormal mitochondria in muscle tissue (HP:0008316)2.79934712
27Medial flaring of the eyebrow (HP:0010747)2.79884732
28Elevated erythrocyte sedimentation rate (HP:0003565)2.73984453
29Acute encephalopathy (HP:0006846)2.70309109
30Abnormality of the renal medulla (HP:0100957)2.69626915
31Tongue fasciculations (HP:0001308)2.67631074
32Progressive macrocephaly (HP:0004481)2.66067719
33Abnormality of T cell physiology (HP:0011840)2.62774562
34Autoimmune hemolytic anemia (HP:0001890)2.60325327
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57677786
36Hepatocellular necrosis (HP:0001404)2.57530968
37Abnormality of urine glucose concentration (HP:0011016)2.55932162
38Glycosuria (HP:0003076)2.55932162
39Large eyes (HP:0001090)2.48673483
40Renal Fanconi syndrome (HP:0001994)2.48354697
41Type I transferrin isoform profile (HP:0003642)2.48244183
42Type 2 muscle fiber atrophy (HP:0003554)2.47050359
43Mesangial abnormality (HP:0001966)2.46906110
44Pancreatic fibrosis (HP:0100732)2.45928142
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45089786
46Optic disc pallor (HP:0000543)2.41339892
47Abnormality of eosinophils (HP:0001879)2.38206653
48Abolished electroretinogram (ERG) (HP:0000550)2.32974252
49Abnormality of B cell number (HP:0010975)2.32176648
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30588989
51Attenuation of retinal blood vessels (HP:0007843)2.27044971
52True hermaphroditism (HP:0010459)2.27038121
53Chronic hepatic failure (HP:0100626)2.25642654
54Exertional dyspnea (HP:0002875)2.23093720
55Muscle fibrillation (HP:0010546)2.22598726
56Abnormal rod and cone electroretinograms (HP:0008323)2.22512753
57Abnormality of T cells (HP:0002843)2.19252823
58Eosinophilia (HP:0001880)2.17954929
59Gait imbalance (HP:0002141)2.17083866
60Hypoproteinemia (HP:0003075)2.15137625
61Hypothermia (HP:0002045)2.14985717
62Limb dystonia (HP:0002451)2.13958899
63Constricted visual fields (HP:0001133)2.13124525
64Lactic acidosis (HP:0003128)2.08337399
65Joint swelling (HP:0001386)2.06171031
66Menstrual irregularities (HP:0000858)2.05704485
67Increased serum lactate (HP:0002151)2.04343718
68Pendular nystagmus (HP:0012043)2.03981750
69Muscle fiber atrophy (HP:0100295)2.00860216
70Increased intramyocellular lipid droplets (HP:0012240)1.96005110
71Abnormality of the labia minora (HP:0012880)1.95140257
72Severe muscular hypotonia (HP:0006829)1.93447873
73Combined immunodeficiency (HP:0005387)1.93207770
74Pachygyria (HP:0001302)1.90414188
75Tubular atrophy (HP:0000092)1.87595222
76Abnormality of T cell number (HP:0011839)1.86281264
77IgA deficiency (HP:0002720)1.85443101
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84571648
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84571648
80Polyuria (HP:0000103)1.84154635
81B lymphocytopenia (HP:0010976)1.84097954
82Cerebral edema (HP:0002181)1.84084773
83Congenital primary aphakia (HP:0007707)1.83801460
84Polydipsia (HP:0001959)1.83745108
85Abnormal drinking behavior (HP:0030082)1.83745108
86Abnormality of the pons (HP:0007361)1.81210033
87Abnormality of midbrain morphology (HP:0002418)1.80856569
88Molar tooth sign on MRI (HP:0002419)1.80856569
89Increased muscle lipid content (HP:0009058)1.78982943
90Testicular atrophy (HP:0000029)1.76655991
91Lethargy (HP:0001254)1.74571228
92Nephrogenic diabetes insipidus (HP:0009806)1.73458133
93Hypoplasia of the pons (HP:0012110)1.73039392
94Decreased central vision (HP:0007663)1.72678858
95Cerebral palsy (HP:0100021)1.72566995
96Abnormal protein N-linked glycosylation (HP:0012347)1.72562095
97Abnormal protein glycosylation (HP:0012346)1.72562095
98Abnormal glycosylation (HP:0012345)1.72562095
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72562095
100Decreased circulating renin level (HP:0003351)1.72461140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.74563605
2VRK24.23920427
3NME23.76547875
4BMPR1B3.28108015
5TLK12.36203207
6TAF12.27155929
7FRK2.20748701
8ADRBK22.14196353
9TXK2.12366984
10ZAK2.11151298
11KIT1.94064895
12INSRR1.91821496
13WNK31.91521339
14VRK11.86075716
15FLT31.84604604
16BCKDK1.83772894
17CAMKK21.79066116
18MKNK11.61763427
19GRK11.60890184
20PASK1.57180459
21MAP4K21.51411751
22ACVR1B1.50104632
23PHKG21.39677307
24PHKG11.39677307
25DYRK21.33077134
26TIE11.32008315
27PKN21.30657756
28WNK41.30458267
29IKBKB1.25994489
30MAP4K11.22821917
31CDK81.22648082
32PINK11.20654086
33TGFBR11.17730642
34KDR1.16087403
35IKBKE1.15545277
36MAPKAPK51.13740058
37GRK61.13476895
38SYK1.11034413
39MARK11.10840752
40NUAK11.07486849
41TNK20.98186909
42MAPK130.96842873
43DAPK20.96725821
44TEC0.94440312
45FES0.93012619
46MAP3K40.92601305
47NME10.92132812
48LYN0.91162652
49MKNK20.89279641
50MAP2K60.85101576
51RPS6KA50.82340897
52ITK0.80475904
53BTK0.78964589
54MAP3K140.77518052
55RPS6KA40.77313661
56STK160.74483947
57ADRBK10.72023912
58CAMKK10.70307414
59TSSK60.65857743
60CHUK0.65097627
61CSK0.63339265
62PRKCQ0.63176085
63BCR0.62953136
64AKT30.61163050
65CSNK1G20.57116639
66MATK0.56818447
67CSNK1G30.55085848
68CDK90.55022470
69MELK0.54143104
70TGFBR20.54142261
71PRKCE0.53422733
72CSNK1A1L0.51880001
73LCK0.50033908
74ABL20.47341620
75CDC70.46626784
76BLK0.45970146
77EIF2AK20.45396536
78MAP2K70.44459515
79NTRK30.40638648
80DYRK1A0.40491342
81MST40.38310602
82PRKD30.38017518
83PIM10.37917235
84PAK30.37844654
85NTRK20.36200758
86BMPR20.36159149
87OXSR10.35872116
88MAP3K70.35630668
89MARK30.35332080
90CASK0.34797515
91OBSCN0.30585875
92PRKACA0.30474405
93STK38L0.30436277
94CSNK1A10.29987548
95PRKCG0.29830699
96FGFR10.28926932
97PRKG10.28215674
98EPHA30.28165931
99PRKCD0.28016236
100PRKCA0.27867330

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.54134044
2Oxidative phosphorylation_Homo sapiens_hsa001903.35853336
3Asthma_Homo sapiens_hsa053103.29413379
4Proteasome_Homo sapiens_hsa030503.26134562
5Autoimmune thyroid disease_Homo sapiens_hsa053203.17158229
6Type I diabetes mellitus_Homo sapiens_hsa049402.88748406
7Graft-versus-host disease_Homo sapiens_hsa053322.80921767
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.80470539
9Parkinsons disease_Homo sapiens_hsa050122.75101762
10Protein export_Homo sapiens_hsa030602.58757564
11Ribosome_Homo sapiens_hsa030102.40482982
12Primary immunodeficiency_Homo sapiens_hsa053402.26829147
13Linoleic acid metabolism_Homo sapiens_hsa005912.22561792
14Alzheimers disease_Homo sapiens_hsa050101.85618504
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83557668
16RNA polymerase_Homo sapiens_hsa030201.83214047
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.82598171
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78305324
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76655073
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70431065
21Cardiac muscle contraction_Homo sapiens_hsa042601.64588684
22Vitamin B6 metabolism_Homo sapiens_hsa007501.64377226
23Selenocompound metabolism_Homo sapiens_hsa004501.64219408
24Huntingtons disease_Homo sapiens_hsa050161.56847421
25Rheumatoid arthritis_Homo sapiens_hsa053231.52072012
26Phototransduction_Homo sapiens_hsa047441.51172951
27Caffeine metabolism_Homo sapiens_hsa002321.31278389
28Systemic lupus erythematosus_Homo sapiens_hsa053221.31190984
29Arachidonic acid metabolism_Homo sapiens_hsa005901.28654399
30Antigen processing and presentation_Homo sapiens_hsa046121.25290017
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22092007
32Basal transcription factors_Homo sapiens_hsa030221.21797660
33Hematopoietic cell lineage_Homo sapiens_hsa046401.18419398
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15691435
35RNA degradation_Homo sapiens_hsa030181.14819222
36Regulation of autophagy_Homo sapiens_hsa041401.08634580
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03943913
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01242051
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00735988
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.00238229
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96472187
42Butanoate metabolism_Homo sapiens_hsa006500.92937190
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.88864072
44Propanoate metabolism_Homo sapiens_hsa006400.85372718
45Chemical carcinogenesis_Homo sapiens_hsa052040.84547149
46Ovarian steroidogenesis_Homo sapiens_hsa049130.84075265
47Ether lipid metabolism_Homo sapiens_hsa005650.80441153
48T cell receptor signaling pathway_Homo sapiens_hsa046600.80153231
49Nicotine addiction_Homo sapiens_hsa050330.78896050
50Tryptophan metabolism_Homo sapiens_hsa003800.78871617
51Nitrogen metabolism_Homo sapiens_hsa009100.78144838
52Retinol metabolism_Homo sapiens_hsa008300.74774988
53Staphylococcus aureus infection_Homo sapiens_hsa051500.74118860
54Pyrimidine metabolism_Homo sapiens_hsa002400.71810878
55Olfactory transduction_Homo sapiens_hsa047400.71185700
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.65709997
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64399680
58Fanconi anemia pathway_Homo sapiens_hsa034600.63861274
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62932906
60Insulin secretion_Homo sapiens_hsa049110.62214434
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61994875
62Viral myocarditis_Homo sapiens_hsa054160.59680863
63Mineral absorption_Homo sapiens_hsa049780.59241484
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59121283
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57098937
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57072756
67Purine metabolism_Homo sapiens_hsa002300.55584081
68Fat digestion and absorption_Homo sapiens_hsa049750.54114135
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51886069
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51726661
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51442474
72Taste transduction_Homo sapiens_hsa047420.50364007
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.49247687
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48137130
75Spliceosome_Homo sapiens_hsa030400.46017348
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45238373
77Homologous recombination_Homo sapiens_hsa034400.44742218
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42802124
79African trypanosomiasis_Homo sapiens_hsa051430.42597663
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41570448
81One carbon pool by folate_Homo sapiens_hsa006700.41371575
82Metabolic pathways_Homo sapiens_hsa011000.40618104
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36782205
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36703583
85Epstein-Barr virus infection_Homo sapiens_hsa051690.36539300
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.36025523
87Measles_Homo sapiens_hsa051620.35222826
88Peroxisome_Homo sapiens_hsa041460.34394617
89TNF signaling pathway_Homo sapiens_hsa046680.34360267
90Morphine addiction_Homo sapiens_hsa050320.34117982
91RNA transport_Homo sapiens_hsa030130.31665420
92beta-Alanine metabolism_Homo sapiens_hsa004100.30659382
93Leishmaniasis_Homo sapiens_hsa051400.30169348
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29028847
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27800103
96TGF-beta signaling pathway_Homo sapiens_hsa043500.24960670
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24811014
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.23182098
99Serotonergic synapse_Homo sapiens_hsa047260.21842881
100ABC transporters_Homo sapiens_hsa020100.21762191

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