UBA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.27405059
2cullin deneddylation (GO:0010388)4.69865298
3protein deneddylation (GO:0000338)4.05971594
4DNA ligation (GO:0006266)4.00062523
5establishment of integrated proviral latency (GO:0075713)3.95288259
6DNA deamination (GO:0045006)3.93487814
7regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.88761174
8regulation of acyl-CoA biosynthetic process (GO:0050812)3.83943694
9regulation of cofactor metabolic process (GO:0051193)3.82386385
10regulation of coenzyme metabolic process (GO:0051196)3.82386385
11DNA catabolic process, exonucleolytic (GO:0000738)3.81609435
12regulation of cellular amino acid metabolic process (GO:0006521)3.78867764
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74598375
14purine nucleobase biosynthetic process (GO:0009113)3.73910851
15signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69010627
16signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69010627
17signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69010627
18platelet dense granule organization (GO:0060155)3.68389249
19ribosome assembly (GO:0042255)3.66798909
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65301234
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65301234
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.63381711
23tricarboxylic acid cycle (GO:0006099)3.61859173
24non-recombinational repair (GO:0000726)3.60588031
25double-strand break repair via nonhomologous end joining (GO:0006303)3.60588031
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57416655
27regulation of mitotic spindle checkpoint (GO:1903504)3.57416655
28respiratory chain complex IV assembly (GO:0008535)3.55959772
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55017934
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.51008094
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.45466383
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45466383
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.44071301
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.43344967
35isotype switching (GO:0045190)3.43344967
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.43344967
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42929126
38negative regulation of fibroblast apoptotic process (GO:2000270)3.40674321
39nuclear pore organization (GO:0006999)3.36310718
40histone H2A acetylation (GO:0043968)3.34578866
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32902462
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.32902462
43positive regulation of ligase activity (GO:0051351)3.30182429
44negative regulation of DNA recombination (GO:0045910)3.29134279
45histone mRNA metabolic process (GO:0008334)3.27892851
46mitotic metaphase plate congression (GO:0007080)3.24138208
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22701475
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22701475
49histone exchange (GO:0043486)3.19602637
50replication fork processing (GO:0031297)3.19142027
51response to X-ray (GO:0010165)3.18996850
52nucleobase biosynthetic process (GO:0046112)3.18383902
53negative regulation of DNA repair (GO:0045738)3.14688624
54rRNA modification (GO:0000154)3.13611562
55branched-chain amino acid catabolic process (GO:0009083)3.11490369
56establishment of viral latency (GO:0019043)3.07269852
57regulation of helicase activity (GO:0051095)3.01760347
58mitotic sister chromatid segregation (GO:0000070)3.01647558
59* protein neddylation (GO:0045116)3.00283530
60regulation of ubiquitin-protein transferase activity (GO:0051438)2.99843484
61lactate metabolic process (GO:0006089)2.99569208
62DNA double-strand break processing (GO:0000729)2.98119988
63sister chromatid segregation (GO:0000819)2.96253656
64rRNA methylation (GO:0031167)2.94920298
65regulation of ligase activity (GO:0051340)2.94892650
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94801090
67synaptic vesicle docking involved in exocytosis (GO:0016081)2.93104804
68metaphase plate congression (GO:0051310)2.91444158
69mitochondrial RNA metabolic process (GO:0000959)2.88173083
70regulation of translational termination (GO:0006449)2.88000794
71chondrocyte proliferation (GO:0035988)2.87880523
72regulation of fibroblast apoptotic process (GO:2000269)2.86546294
73cytochrome complex assembly (GO:0017004)2.86531945
74protein K11-linked ubiquitination (GO:0070979)2.84664663
75positive regulation of mitochondrial fission (GO:0090141)2.83270324
76DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82025352
77negative regulation of protein ubiquitination (GO:0031397)2.82025267
78positive regulation of actin filament depolymerization (GO:0030836)2.80256428
79regulation of sulfur metabolic process (GO:0042762)2.79818414
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77430137
81sequestering of actin monomers (GO:0042989)2.75292924
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75146988
83mismatch repair (GO:0006298)2.74838142
84DNA replication-independent nucleosome assembly (GO:0006336)2.74154184
85DNA replication-independent nucleosome organization (GO:0034724)2.74154184
86anterograde synaptic vesicle transport (GO:0048490)2.73676242
87histone mRNA catabolic process (GO:0071044)2.73572241
88protein-cofactor linkage (GO:0018065)2.72868307
89somatic diversification of immunoglobulins (GO:0016445)2.72474432
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71018891
91resolution of meiotic recombination intermediates (GO:0000712)2.70798238
92organelle disassembly (GO:1903008)2.70651166
93IMP biosynthetic process (GO:0006188)2.70540919
94cytidine catabolic process (GO:0006216)2.69956904
95cytidine deamination (GO:0009972)2.69956904
96sequestering of extracellular ligand from receptor (GO:0035581)2.69393395
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68880195
98prenylation (GO:0097354)2.68734421
99protein prenylation (GO:0018342)2.68734421
100peptidyl-arginine methylation (GO:0018216)2.68570234
101peptidyl-arginine N-methylation (GO:0035246)2.68570234
102peptidyl-arginine omega-N-methylation (GO:0035247)2.66622159
103ventricular cardiac muscle cell development (GO:0055015)2.65935594
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64099505
105attachment of spindle microtubules to kinetochore (GO:0008608)2.63429063
106positive regulation of protein complex disassembly (GO:0043243)2.62192821
107establishment of chromosome localization (GO:0051303)2.61865152
108positive regulation of cardiac muscle cell differentiation (GO:2000727)2.58395044
109apical protein localization (GO:0045176)2.58171295
110IMP metabolic process (GO:0046040)2.57390616
111nuclear pore complex assembly (GO:0051292)2.55915784
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.55816762
113ATP hydrolysis coupled proton transport (GO:0015991)2.55816762
114regulation of centriole replication (GO:0046599)2.55346992
115spindle checkpoint (GO:0031577)2.54215794
116chaperone-mediated protein transport (GO:0072321)2.53576348
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52700532
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52525121
119CENP-A containing nucleosome assembly (GO:0034080)2.51304969
120regulation of centrosome cycle (GO:0046605)2.50677946
121glutamate secretion (GO:0014047)2.49186214
122histone arginine methylation (GO:0034969)2.49090794
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48208743
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47049886
125spindle assembly checkpoint (GO:0071173)2.46616626
126mitotic spindle assembly checkpoint (GO:0007094)2.46155089
127transferrin transport (GO:0033572)2.45571126
128chromatin remodeling at centromere (GO:0031055)2.45085011
129negative regulation of dendrite morphogenesis (GO:0050774)2.43929808
130inositol phosphate catabolic process (GO:0071545)2.43459329
131mitotic spindle checkpoint (GO:0071174)2.43305409
132positive regulation of cardiac muscle tissue growth (GO:0055023)2.42558874
133regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41921067
134ferric iron transport (GO:0015682)2.38284147
135trivalent inorganic cation transport (GO:0072512)2.38284147
136regulation of mitotic sister chromatid segregation (GO:0033047)2.36886916
137regulation of sister chromatid segregation (GO:0033045)2.36886916
138regulation of mitotic sister chromatid separation (GO:0010965)2.36886916
139regulation of centrosome duplication (GO:0010824)2.36317882
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.35632073
141negative regulation of sister chromatid segregation (GO:0033046)2.35632073
142negative regulation of mitotic sister chromatid separation (GO:2000816)2.35632073
143negative regulation of mitotic sister chromatid segregation (GO:0033048)2.35632073
144positive regulation of cardiac muscle cell proliferation (GO:0060045)2.34597272
145regulation of mitochondrial fission (GO:0090140)2.33471823
146positive regulation of mitotic sister chromatid separation (GO:1901970)2.33462846
147positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33462846
148positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33462846
149positive regulation of cardiac muscle tissue development (GO:0055025)2.30661837
150mitotic sister chromatid cohesion (GO:0007064)2.30080643
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.29763908
152paraxial mesoderm development (GO:0048339)2.29505154
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.28990751
154positive regulation of muscle hypertrophy (GO:0014742)2.28930455
155positive regulation of cardiac muscle hypertrophy (GO:0010613)2.28930455
156establishment of protein localization to mitochondrial membrane (GO:0090151)2.27704919
157mitochondrial genome maintenance (GO:0000002)2.27559691
158mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.27001344
159regulation of mitotic spindle organization (GO:0060236)2.26972885
160negative regulation of chromosome segregation (GO:0051985)2.26195544
161positive regulation of protein depolymerization (GO:1901881)2.25919243
162mitotic cytokinesis (GO:0000281)2.25500420
163negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.24956790
164negative regulation of ligase activity (GO:0051352)2.24956790
165regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.24607199
166positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.23439635
167axon extension involved in axon guidance (GO:0048846)2.19613782
168neuron projection extension involved in neuron projection guidance (GO:1902284)2.19613782
169positive regulation of heart growth (GO:0060421)2.18273474
170ATP synthesis coupled proton transport (GO:0015986)2.17963071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.17021222
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.08161052
3GBX2_23144817_ChIP-Seq_PC3_Human2.97795650
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.97584357
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91897159
6E2F7_22180533_ChIP-Seq_HELA_Human2.82600841
7FUS_26573619_Chip-Seq_HEK293_Human2.82363652
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53835781
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49592713
10TAF15_26573619_Chip-Seq_HEK293_Human2.47103076
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43665315
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36079696
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33726574
14VDR_23849224_ChIP-Seq_CD4+_Human2.22334837
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.18901465
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16409577
17AR_21909140_ChIP-Seq_LNCAP_Human2.08542254
18EWS_26573619_Chip-Seq_HEK293_Human2.06187695
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05083459
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.04687088
21ELK1_19687146_ChIP-ChIP_HELA_Human2.04628793
22IGF1R_20145208_ChIP-Seq_DFB_Human2.02183044
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00588880
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97018320
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.93878042
26FOXP3_21729870_ChIP-Seq_TREG_Human1.85948502
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.83124507
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79912568
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.79778639
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75181304
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.73854214
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73652311
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68959325
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67481252
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.66717869
36P300_19829295_ChIP-Seq_ESCs_Human1.66390744
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65727831
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65641238
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63991143
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62216331
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61673303
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.54840815
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54181817
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52599544
45SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.51398361
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50784116
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47636459
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46671432
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42797421
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.42707862
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41378668
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.41071399
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41051543
54JUN_21703547_ChIP-Seq_K562_Human1.40532939
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38937906
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38920919
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38874513
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33865705
59ER_23166858_ChIP-Seq_MCF-7_Human1.33269386
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30575264
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.30502371
62MYC_18940864_ChIP-ChIP_HL60_Human1.29868921
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29815023
64SMAD4_21799915_ChIP-Seq_A2780_Human1.29572613
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28852130
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25085302
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25085302
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24451679
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24252597
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23279986
71* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23114576
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22746196
73SOX9_26525672_Chip-Seq_HEART_Mouse1.22427497
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.21488607
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.21287954
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21169461
77VDR_22108803_ChIP-Seq_LS180_Human1.20135634
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20132198
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.18680896
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.18348255
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.17206043
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16118981
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.15495360
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14243388
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13520081
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13163196
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.12695349
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12496812
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12401718
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.12257234
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.11836677
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11482053
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11303936
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10778208
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10486533
96TP53_18474530_ChIP-ChIP_U2OS_Human1.09930705
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08670914
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.07119250
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06835063
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06226574
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.05406226
102NANOG_19829295_ChIP-Seq_ESCs_Human1.04693647
103SOX2_19829295_ChIP-Seq_ESCs_Human1.04693647
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03413864
105P53_22387025_ChIP-Seq_ESCs_Mouse1.03298685
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03152756
107CBP_20019798_ChIP-Seq_JUKART_Human1.03152756
108DCP1A_22483619_ChIP-Seq_HELA_Human1.02826680
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02445475
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02278176
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01537511
112IRF1_19129219_ChIP-ChIP_H3396_Human1.01384749
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01308917
114BRD4_25478319_ChIP-Seq_HGPS_Human1.01182098
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00779612
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00209577
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99696920
118* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99359478
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99000356
120TP53_16413492_ChIP-PET_HCT116_Human0.98681834
121ZNF274_21170338_ChIP-Seq_K562_Hela0.98407173
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98089489
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97888865
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97791596
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97571161
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97303904
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97159740
128P300_18555785_Chip-Seq_ESCs_Mouse0.97057543
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96725753
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96200248
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96175929
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95736331
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95715176
134STAT3_23295773_ChIP-Seq_U87_Human0.95674701
135EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95574304
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95532966
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95454882
138KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95437108
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.93978411
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93748903
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.93496155
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93270581
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.93144559
144AR_25329375_ChIP-Seq_VCAP_Human0.92584528
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92474697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.16745183
2MP0003123_paternal_imprinting3.20204440
3MP0006054_spinal_hemorrhage2.78725065
4MP0008438_abnormal_cutaneous_collagen2.61675877
5MP0005503_abnormal_tendon_morphology2.56582543
6MP0008057_abnormal_DNA_replication2.36362798
7MP0003718_maternal_effect2.28624300
8MP0006072_abnormal_retinal_apoptosis2.24861282
9MP0003121_genomic_imprinting2.24069724
10MP0005075_abnormal_melanosome_morpholog2.22669975
11MP0003786_premature_aging2.19968005
12MP0001984_abnormal_olfaction2.17483588
13MP0003122_maternal_imprinting2.16323709
14MP0003693_abnormal_embryo_hatching2.13674583
15MP0008789_abnormal_olfactory_epithelium2.09293299
16MP0009384_cardiac_valve_regurgitation2.05833056
17MP0004084_abnormal_cardiac_muscle1.96377391
18MP0005171_absent_coat_pigmentation1.95966448
19MP0003787_abnormal_imprinting1.90843055
20MP0002735_abnormal_chemical_nociception1.89341197
21MP0001299_abnormal_eye_distance/1.82345877
22MP0005623_abnormal_meninges_morphology1.81830032
23MP0003880_abnormal_central_pattern1.74069259
24MP0003195_calcinosis1.70307547
25MP0005253_abnormal_eye_physiology1.69719726
26MP0005275_abnormal_skin_tensile1.69312620
27MP0003186_abnormal_redox_activity1.67982483
28MP0009046_muscle_twitch1.66461249
29MP0000537_abnormal_urethra_morphology1.64924291
30MP0006035_abnormal_mitochondrial_morpho1.63028367
31MP0005084_abnormal_gallbladder_morpholo1.62304825
32MP0004233_abnormal_muscle_weight1.60719600
33MP0001968_abnormal_touch/_nociception1.58749850
34MP0010094_abnormal_chromosome_stability1.58225168
35MP0006036_abnormal_mitochondrial_physio1.57980579
36MP0002736_abnormal_nociception_after1.52097633
37MP0009697_abnormal_copulation1.52050378
38MP0004215_abnormal_myocardial_fiber1.49815335
39MP0001529_abnormal_vocalization1.49554463
40MP0000749_muscle_degeneration1.47031663
41MP0001835_abnormal_antigen_presentation1.45507062
42MP0003950_abnormal_plasma_membrane1.45091088
43MP0000751_myopathy1.42460465
44MP0001188_hyperpigmentation1.41156484
45MP0003724_increased_susceptibility_to1.40939636
46MP0009250_abnormal_appendicular_skeleto1.39955045
47MP0000372_irregular_coat_pigmentation1.38526798
48* MP0008932_abnormal_embryonic_tissue1.38402581
49MP0003937_abnormal_limbs/digits/tail_de1.36295891
50MP0004859_abnormal_synaptic_plasticity1.35333555
51MP0005499_abnormal_olfactory_system1.34373861
52MP0005394_taste/olfaction_phenotype1.34373861
53MP0005671_abnormal_response_to1.33098862
54* MP0004957_abnormal_blastocyst_morpholog1.32881014
55MP0009780_abnormal_chondrocyte_physiolo1.28322231
56MP0000569_abnormal_digit_pigmentation1.27598056
57MP0004272_abnormal_basement_membrane1.26854735
58MP0004270_analgesia1.26048165
59MP0003385_abnormal_body_wall1.25280569
60MP0004484_altered_response_of1.24369309
61MP0003890_abnormal_embryonic-extraembry1.22035636
62MP0002734_abnormal_mechanical_nocicepti1.21694444
63MP0002282_abnormal_trachea_morphology1.20273524
64MP0004036_abnormal_muscle_relaxation1.17782727
65MP0003755_abnormal_palate_morphology1.17382446
66MP0002837_dystrophic_cardiac_calcinosis1.16880261
67MP0002108_abnormal_muscle_morphology1.16455520
68MP0009745_abnormal_behavioral_response1.15919688
69MP0001485_abnormal_pinna_reflex1.14919689
70MP0002938_white_spotting1.14054345
71MP0002972_abnormal_cardiac_muscle1.13812367
72MP0002102_abnormal_ear_morphology1.13644477
73MP0005646_abnormal_pituitary_gland1.13520066
74MP0006276_abnormal_autonomic_nervous1.13463658
75MP0008877_abnormal_DNA_methylation1.12737285
76MP0009785_altered_susceptibility_to1.12725211
77MP0002006_tumorigenesis1.12389922
78MP0002064_seizures1.11273632
79MP0004134_abnormal_chest_morphology1.10676201
80MP0003806_abnormal_nucleotide_metabolis1.10341534
81MP0003635_abnormal_synaptic_transmissio1.07110271
82MP0001293_anophthalmia1.06197987
83MP0010030_abnormal_orbit_morphology1.06126873
84* MP0003077_abnormal_cell_cycle1.05223425
85MP0005551_abnormal_eye_electrophysiolog1.04998153
86MP0002877_abnormal_melanocyte_morpholog1.04458612
87MP0002063_abnormal_learning/memory/cond1.02665859
88MP0002166_altered_tumor_susceptibility1.00808621
89MP0003221_abnormal_cardiomyocyte_apopto1.00749837
90MP0000778_abnormal_nervous_system1.00587259
91MP0003941_abnormal_skin_development0.99159219
92MP0008007_abnormal_cellular_replicative0.98106318
93MP0003137_abnormal_impulse_conducting0.97988823
94MP0005620_abnormal_muscle_contractility0.97963680
95MP0009053_abnormal_anal_canal0.97901106
96MP0008775_abnormal_heart_ventricle0.97398077
97MP0001440_abnormal_grooming_behavior0.95764514
98MP0002233_abnormal_nose_morphology0.95452057
99MP0003111_abnormal_nucleus_morphology0.95297059
100MP0000013_abnormal_adipose_tissue0.94961426
101MP0004197_abnormal_fetal_growth/weight/0.94389733
102MP0002184_abnormal_innervation0.92538032
103MP0002272_abnormal_nervous_system0.92240119
104MP0002090_abnormal_vision0.91930356
105MP0005508_abnormal_skeleton_morphology0.91260153
106MP0000428_abnormal_craniofacial_morphol0.90925679
107MP0001730_embryonic_growth_arrest0.90396216
108MP0001853_heart_inflammation0.89590718
109MP0006138_congestive_heart_failure0.88930774
110MP0002572_abnormal_emotion/affect_behav0.88526146
111MP0000647_abnormal_sebaceous_gland0.87596523
112MP0002067_abnormal_sensory_capabilities0.87593241
113MP0003942_abnormal_urinary_system0.87558300
114MP0000566_synostosis0.87280442
115MP0004782_abnormal_surfactant_physiolog0.86686232
116MP0000516_abnormal_urinary_system0.86451804
117MP0005367_renal/urinary_system_phenotyp0.86451804
118MP0004924_abnormal_behavior0.86319239
119MP0005386_behavior/neurological_phenoty0.86319239
120MP0001764_abnormal_homeostasis0.84670862
121MP0000689_abnormal_spleen_morphology0.84587602
122MP0000350_abnormal_cell_proliferation0.83807573
123MP0001697_abnormal_embryo_size0.81203878
124MP0000762_abnormal_tongue_morphology0.80788328
125MP0003567_abnormal_fetal_cardiomyocyte0.80467387
126MP0005395_other_phenotype0.79206229
127MP0001929_abnormal_gametogenesis0.78227314
128MP0001324_abnormal_eye_pigmentation0.77798218
129MP0005369_muscle_phenotype0.77421326
130MP0001119_abnormal_female_reproductive0.77409442
131MP0008995_early_reproductive_senescence0.77180362
132MP0002751_abnormal_autonomic_nervous0.77148080
133MP0010307_abnormal_tumor_latency0.76916918
134MP0005408_hypopigmentation0.76651465
135MP0001177_atelectasis0.76597853
136MP0002019_abnormal_tumor_incidence0.76373555
137MP0003646_muscle_fatigue0.76059494
138MP0002177_abnormal_outer_ear0.75829904
139MP0000358_abnormal_cell_content/0.75549653
140MP0002277_abnormal_respiratory_mucosa0.75417163
141MP0009764_decreased_sensitivity_to0.75413820
142MP0002084_abnormal_developmental_patter0.75393171
143MP0005380_embryogenesis_phenotype0.75068814
144MP0001672_abnormal_embryogenesis/_devel0.75068814
145MP0002114_abnormal_axial_skeleton0.74898780
146MP0002396_abnormal_hematopoietic_system0.74167011
147MP0003984_embryonic_growth_retardation0.73953600
148MP0008873_increased_physiological_sensi0.73682772
149MP0000465_gastrointestinal_hemorrhage0.73359118
150MP0009765_abnormal_xenobiotic_induced0.70701128
151MP0004147_increased_porphyrin_level0.70616899
152MP0003136_yellow_coat_color0.68167800
153MP0002095_abnormal_skin_pigmentation0.66106785
154MP0002148_abnormal_hypersensitivity_rea0.64282990
155MP0003011_delayed_dark_adaptation0.62284218
156MP0000313_abnormal_cell_death0.61726576
157MP0004142_abnormal_muscle_tone0.61112117
158MP0000653_abnormal_sex_gland0.60481112
159MP0002234_abnormal_pharynx_morphology0.58704429
160MP0002722_abnormal_immune_system0.58413975
161MP0006292_abnormal_olfactory_placode0.57892834
162MP0004085_abnormal_heartbeat0.57628668
163MP0005174_abnormal_tail_pigmentation0.57303495

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.15955135
2Abnormality of glycolysis (HP:0004366)4.15955135
3Abnormality of the labia minora (HP:0012880)3.68310776
4Atonic seizures (HP:0010819)3.65507914
5Medial flaring of the eyebrow (HP:0010747)2.95836927
6Focal motor seizures (HP:0011153)2.95732388
7Methylmalonic acidemia (HP:0002912)2.93319367
8Renal cortical cysts (HP:0000803)2.80948365
9Abnormal mitochondria in muscle tissue (HP:0008316)2.68372126
10Acute necrotizing encephalopathy (HP:0006965)2.67701521
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64691817
12Abnormality of alanine metabolism (HP:0010916)2.64691817
13Hyperalaninemia (HP:0003348)2.64691817
14Pancreatic cysts (HP:0001737)2.62956885
15Epileptic encephalopathy (HP:0200134)2.62099002
16Increased hepatocellular lipid droplets (HP:0006565)2.59133269
17Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57107758
18Ependymoma (HP:0002888)2.54512157
19Volvulus (HP:0002580)2.50149327
20Progressive macrocephaly (HP:0004481)2.45944705
21Protrusio acetabuli (HP:0003179)2.40771436
22Shoulder girdle muscle weakness (HP:0003547)2.37918400
23True hermaphroditism (HP:0010459)2.37477544
24Nephrogenic diabetes insipidus (HP:0009806)2.36599823
25Abnormality of methionine metabolism (HP:0010901)2.35595432
26Premature rupture of membranes (HP:0001788)2.31034742
27Hyperglycinemia (HP:0002154)2.29907386
28Fetal akinesia sequence (HP:0001989)2.27508297
29Cerebral edema (HP:0002181)2.26660796
30Abnormality of serum amino acid levels (HP:0003112)2.26575519
31Pancreatic fibrosis (HP:0100732)2.25582779
32Neoplasm of the adrenal gland (HP:0100631)2.24901627
333-Methylglutaconic aciduria (HP:0003535)2.23471878
34Abolished electroretinogram (ERG) (HP:0000550)2.23435690
35Rhabdomyosarcoma (HP:0002859)2.22790816
36Methylmalonic aciduria (HP:0012120)2.22580897
37Pheochromocytoma (HP:0002666)2.18682177
38Lipid accumulation in hepatocytes (HP:0006561)2.18225169
39Exercise-induced muscle cramps (HP:0003710)2.17407187
40Increased serum lactate (HP:0002151)2.17101835
41Degeneration of anterior horn cells (HP:0002398)2.16071226
42Abnormality of the anterior horn cell (HP:0006802)2.16071226
43Gonadotropin excess (HP:0000837)2.14378061
44Abnormality of the renal cortex (HP:0011035)2.13542367
45Atrophy/Degeneration involving motor neurons (HP:0007373)2.13198699
46Abnormality of chromosome stability (HP:0003220)2.12361436
47Thyroiditis (HP:0100646)2.10740581
48Severe combined immunodeficiency (HP:0004430)2.09886343
49Hyperventilation (HP:0002883)2.09836223
50Medulloblastoma (HP:0002885)2.08337831
51Increased CSF lactate (HP:0002490)2.07646355
52Febrile seizures (HP:0002373)2.07380191
53Resting tremor (HP:0002322)2.07224445
54Wrist flexion contracture (HP:0001239)2.07210049
55Abnormal hair whorl (HP:0010721)2.07154338
56Genital tract atresia (HP:0001827)2.07112868
57Lactic acidosis (HP:0003128)2.06845806
58Delayed gross motor development (HP:0002194)2.05431266
59Absence seizures (HP:0002121)2.03672954
60Neuroendocrine neoplasm (HP:0100634)2.02330681
61Vaginal atresia (HP:0000148)2.01707574
62Type I transferrin isoform profile (HP:0003642)1.99841998
63Molar tooth sign on MRI (HP:0002419)1.99386600
64Abnormality of midbrain morphology (HP:0002418)1.99386600
65Palpitations (HP:0001962)1.98816786
66Microglossia (HP:0000171)1.98651660
67Hypoglycemic coma (HP:0001325)1.98218443
68Abnormal lung lobation (HP:0002101)1.97749498
69IgG deficiency (HP:0004315)1.96054489
70Combined immunodeficiency (HP:0005387)1.95335847
71Irregular epiphyses (HP:0010582)1.94154647
72Abnormality of glycine metabolism (HP:0010895)1.94137666
73Abnormality of serine family amino acid metabolism (HP:0010894)1.94137666
74Abnormality of T cell number (HP:0011839)1.93292023
75Termporal pattern (HP:0011008)1.92692248
76Insidious onset (HP:0003587)1.92692248
77Cortical dysplasia (HP:0002539)1.92645068
78Akinesia (HP:0002304)1.92340696
79Aplastic anemia (HP:0001915)1.92106684
80Amyotrophic lateral sclerosis (HP:0007354)1.91860063
81Poor suck (HP:0002033)1.91749542
82Hypoglycemic seizures (HP:0002173)1.91687911
83Hypoplastic heart (HP:0001961)1.91143379
84Mitochondrial inheritance (HP:0001427)1.91025991
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90707902
86Abnormal protein N-linked glycosylation (HP:0012347)1.90707902
87Abnormal protein glycosylation (HP:0012346)1.90707902
88Abnormal glycosylation (HP:0012345)1.90707902
89Progressive inability to walk (HP:0002505)1.90578265
90T lymphocytopenia (HP:0005403)1.89647723
91Postnatal microcephaly (HP:0005484)1.88937126
92Mild short stature (HP:0003502)1.88717943
93Focal seizures (HP:0007359)1.88487802
94Abnormality of B cell number (HP:0010975)1.88383515
95Abnormality of the fovea (HP:0000493)1.86659976
96Pancreatic islet-cell hyperplasia (HP:0004510)1.86157759
97Supernumerary spleens (HP:0009799)1.86038369
98Meckel diverticulum (HP:0002245)1.84498921
99Exertional dyspnea (HP:0002875)1.84398413
100Acute encephalopathy (HP:0006846)1.83541152
101Abnormality of the ileum (HP:0001549)1.82872203
102Dialeptic seizures (HP:0011146)1.82871958
103Abnormality of dentin (HP:0010299)1.81711781
104Intestinal atresia (HP:0011100)1.80419379
105Respiratory failure (HP:0002878)1.77858201
106Hepatocellular necrosis (HP:0001404)1.77287764
107Nephronophthisis (HP:0000090)1.77159102
108Abnormality of cochlea (HP:0000375)1.76770954
109Stomach cancer (HP:0012126)1.76533646
110Carpal bone hypoplasia (HP:0001498)1.75360477
111Abnormality of the vitamin B12 metabolism (HP:0004341)1.74367545
112Biliary tract neoplasm (HP:0100574)1.73725762
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.73590075
114Neoplasm of the colon (HP:0100273)1.72706401
115Myelomeningocele (HP:0002475)1.72457051
116Abnormality of the hip-girdle musculature (HP:0001445)1.71674758
117Abnormality of the musculature of the pelvis (HP:0001469)1.71674758
118Hyperglycinuria (HP:0003108)1.71452776
119Tubulointerstitial nephritis (HP:0001970)1.71029275
120Cerebral hypomyelination (HP:0006808)1.70837128
121Renal Fanconi syndrome (HP:0001994)1.70753169
122Broad foot (HP:0001769)1.70696704
123Hypoplastic left heart (HP:0004383)1.70279403
124Colon cancer (HP:0003003)1.69858110
125Pelvic girdle muscle weakness (HP:0003749)1.69815509
126Soft skin (HP:0000977)1.69745285
127Aplasia of the musculature (HP:0100854)1.69092753
128Slender build (HP:0001533)1.68551766
129Abnormal biliary tract physiology (HP:0012439)1.67667352
130Bile duct proliferation (HP:0001408)1.67667352
131Excessive salivation (HP:0003781)1.65792764
132Drooling (HP:0002307)1.65792764
133Abnormality of pain sensation (HP:0010832)1.63029975
134Impaired pain sensation (HP:0007328)1.63029975
135Astrocytoma (HP:0009592)1.62333950
136Abnormality of the astrocytes (HP:0100707)1.62333950
137Embryonal renal neoplasm (HP:0011794)1.60450081
138Autoamputation (HP:0001218)1.58978232
139Relative macrocephaly (HP:0004482)1.58853582
140X-linked dominant inheritance (HP:0001423)1.58543634
141Abnormality of the calf musculature (HP:0001430)1.57324963
142Neoplasm of the peripheral nervous system (HP:0100007)1.56803055
143Type 2 muscle fiber atrophy (HP:0003554)1.56556413
144Neuroblastoma (HP:0003006)1.53264142
145Primitive neuroectodermal tumor (HP:0030065)1.53264142
146Neuroblastic tumors (HP:0004376)1.53264142
147Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.53264142
148Hypothermia (HP:0002045)1.52730165
149Agnosia (HP:0010524)1.51949475
150Abnormality of the ischium (HP:0003174)1.51289816
151Rimmed vacuoles (HP:0003805)1.50962170
152Short foot (HP:0001773)1.50919661
153Limb-girdle muscle weakness (HP:0003325)1.50846697
154Sensory axonal neuropathy (HP:0003390)1.50561139
155Birth length less than 3rd percentile (HP:0003561)1.50486466
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50324773
157Hyperthyroidism (HP:0000836)1.50119294
158Delayed epiphyseal ossification (HP:0002663)1.49942379
159Freckling (HP:0001480)1.49438852
160Nephroblastoma (Wilms tumor) (HP:0002667)1.49323454
161Exercise intolerance (HP:0003546)1.49269064
162Neoplasm of the rectum (HP:0100743)1.48282888
163Respiratory insufficiency due to muscle weakness (HP:0002747)1.48046844
164Spinal rigidity (HP:0003306)1.47698679
165Mesomelia (HP:0003027)1.45592500
166Hepatic necrosis (HP:0002605)1.45409042
167Congenital primary aphakia (HP:0007707)1.45077984
168Gait imbalance (HP:0002141)1.44359228
169Leukodystrophy (HP:0002415)1.43011915
170Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.42597832
171Hypoplastic ischia (HP:0003175)1.41882101
172Adrenal hypoplasia (HP:0000835)1.41830628
173Glioma (HP:0009733)1.41359611
174Abnormality of the shoulder girdle musculature (HP:0001435)1.41038728
175Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39756736
176Absent epiphyses (HP:0010577)1.39756736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.79229308
2TRIM283.13861078
3MST42.83501156
4NUAK12.71380979
5PLK22.59439516
6TSSK62.42571100
7BCR2.36311893
8NEK12.35740629
9CDC72.30554041
10WNK32.18823090
11MAP3K42.15426873
12LIMK12.10044397
13MAP4K22.08800842
14BUB12.07352482
15MAP3K122.04269030
16MAP2K71.98279805
17TXK1.97823094
18PDK41.97445877
19PDK31.97445877
20STK38L1.96109999
21EIF2AK11.88788034
22PLK31.82861200
23AKT31.82551549
24CCNB11.82272575
25BRSK21.69443235
26PDK21.64736104
27BRSK11.60168968
28SIK31.55233076
29VRK21.52941632
30STK161.51716249
31PBK1.50369012
32LATS21.47924953
33MINK11.41838889
34ACVR1B1.37913380
35WEE11.37589186
36MKNK11.37273097
37ERBB31.37218304
38FER1.34982433
39ERBB41.30334094
40CDK81.25221250
41TEC1.24764258
42KSR11.20757488
43MET1.11964224
44LATS11.10786274
45BCKDK1.09873992
46EIF2AK21.08931936
47CDK191.08436944
48PIK3CA1.07628424
49MAP2K41.05803618
50TNIK1.04715018
51ZAK1.03723669
52TTK1.03539051
53CSNK1G11.03422871
54TIE11.02657661
55BRAF1.01349173
56GRK11.00979629
57NTRK30.97733009
58MOS0.94009994
59PRPF4B0.93571544
60OXSR10.92755301
61MELK0.92590015
62PINK10.90335609
63OBSCN0.89659240
64STK240.89636558
65CDK140.89619739
66MYLK0.89608567
67ADRBK10.88306036
68BMPR1B0.88110489
69FGFR10.88070914
70CDK180.87212559
71ADRBK20.85512894
72SRPK10.83716220
73MAPK130.83209848
74EPHA20.83048789
75TAF10.82572970
76FRK0.81966195
77DDR20.79424679
78CSNK1A1L0.77525789
79KDR0.77123958
80CAMKK20.76832406
81CDK150.75105870
82PLK10.75037908
83STK100.74705088
84RPS6KA40.73257874
85PRKCE0.70325672
86INSRR0.69924898
87FLT30.67942959
88STK390.67424910
89MAP2K10.66646172
90NEK90.66633906
91PRKCG0.66185943
92CSNK1G20.66153070
93TRPM70.65728777
94TESK10.65270521
95ARAF0.64956117
96TTN0.64617730
97AURKA0.63783316
98PLK40.63169760
99MKNK20.62406897
100NME10.61661973
101NEK60.61292628
102STK30.61090118
103PAK30.59567203
104VRK10.59447267
105CDK11A0.58445960
106PNCK0.55410937
107CAMK2A0.53657261
108ROCK20.52006274
109AURKB0.51383543
110SCYL20.50528245
111ITK0.50430772
112MAP3K60.50156810
113FES0.49686738
114CHEK20.48231817
115MAP3K90.48182918
116CSNK1G30.47643076
117ATM0.47292202
118ROCK10.47289094
119DYRK20.47094640
120MAP3K50.46880905
121FGFR20.45098394
122KIT0.43453885
123CAMK2B0.43330488
124ATR0.43279096
125GRK70.42847538
126BMPR20.42605440
127EIF2AK30.41964809
128YES10.41816255
129CHEK10.40395643
130PRKCQ0.39977718
131EGFR0.39614594
132IGF1R0.39533595
133DAPK10.39499059
134TGFBR10.38069670
135MARK30.37258617
136CSNK2A10.37076395
137PASK0.36618335
138CDK30.34763013
139ABL10.31634047
140DYRK30.31335177
141CSNK2A20.30203182
142STK40.30197831
143TGFBR20.28614093

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.91746956
2Proteasome_Homo sapiens_hsa030502.91578662
3Collecting duct acid secretion_Homo sapiens_hsa049662.37581248
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27086712
5Synaptic vesicle cycle_Homo sapiens_hsa047212.26051344
6Oxidative phosphorylation_Homo sapiens_hsa001902.23833304
7Cell cycle_Homo sapiens_hsa041102.16579544
8Vibrio cholerae infection_Homo sapiens_hsa051102.12634236
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09702129
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00171106
11Nicotine addiction_Homo sapiens_hsa050331.96323030
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92851113
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84989258
14Fanconi anemia pathway_Homo sapiens_hsa034601.81193611
15RNA transport_Homo sapiens_hsa030131.80447268
16Parkinsons disease_Homo sapiens_hsa050121.79204472
17RNA polymerase_Homo sapiens_hsa030201.78922336
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68823550
19Oocyte meiosis_Homo sapiens_hsa041141.68648768
20Base excision repair_Homo sapiens_hsa034101.64531252
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56590925
22Steroid biosynthesis_Homo sapiens_hsa001001.51652411
23Nucleotide excision repair_Homo sapiens_hsa034201.46621448
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44726360
25Huntingtons disease_Homo sapiens_hsa050161.41739925
26Basal transcription factors_Homo sapiens_hsa030221.36252652
27Pyruvate metabolism_Homo sapiens_hsa006201.34094431
28Mismatch repair_Homo sapiens_hsa034301.28113589
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25403937
30Primary immunodeficiency_Homo sapiens_hsa053401.23536138
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23491919
32Spliceosome_Homo sapiens_hsa030401.23306939
33TGF-beta signaling pathway_Homo sapiens_hsa043501.22579162
34Peroxisome_Homo sapiens_hsa041461.20478545
35Alzheimers disease_Homo sapiens_hsa050101.20342997
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18038799
37Butanoate metabolism_Homo sapiens_hsa006501.16350498
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15367320
39Carbon metabolism_Homo sapiens_hsa012001.15123074
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14458715
41Dopaminergic synapse_Homo sapiens_hsa047281.13977266
42Hippo signaling pathway_Homo sapiens_hsa043901.12848244
43* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09435942
44Long-term potentiation_Homo sapiens_hsa047201.08704593
45DNA replication_Homo sapiens_hsa030301.06154275
46Melanoma_Homo sapiens_hsa052181.05618484
47Regulation of autophagy_Homo sapiens_hsa041401.04713541
48GABAergic synapse_Homo sapiens_hsa047271.00011276
49Long-term depression_Homo sapiens_hsa047300.98751576
50Sulfur metabolism_Homo sapiens_hsa009200.98391915
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96496814
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96238815
53Phagosome_Homo sapiens_hsa041450.96229270
54RNA degradation_Homo sapiens_hsa030180.95940069
55Serotonergic synapse_Homo sapiens_hsa047260.94768468
56Amphetamine addiction_Homo sapiens_hsa050310.93974114
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93437696
58Alcoholism_Homo sapiens_hsa050340.92459448
59Cardiac muscle contraction_Homo sapiens_hsa042600.91608813
60Fatty acid metabolism_Homo sapiens_hsa012120.91493351
61Dilated cardiomyopathy_Homo sapiens_hsa054140.90837632
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89926598
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89549294
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89469526
65ECM-receptor interaction_Homo sapiens_hsa045120.88965635
66Biosynthesis of amino acids_Homo sapiens_hsa012300.86269923
67Homologous recombination_Homo sapiens_hsa034400.84973033
68Gap junction_Homo sapiens_hsa045400.84430749
69Phototransduction_Homo sapiens_hsa047440.84097560
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83994178
71Tight junction_Homo sapiens_hsa045300.82958998
72Antigen processing and presentation_Homo sapiens_hsa046120.82611391
73Asthma_Homo sapiens_hsa053100.81950668
74Axon guidance_Homo sapiens_hsa043600.81826906
75Morphine addiction_Homo sapiens_hsa050320.81428438
76Legionellosis_Homo sapiens_hsa051340.79009084
77Circadian entrainment_Homo sapiens_hsa047130.78563168
78Tryptophan metabolism_Homo sapiens_hsa003800.78367470
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.77853650
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77532088
81Allograft rejection_Homo sapiens_hsa053300.75927424
82Selenocompound metabolism_Homo sapiens_hsa004500.75686995
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75264632
84Focal adhesion_Homo sapiens_hsa045100.72978963
85Viral carcinogenesis_Homo sapiens_hsa052030.72744149
86Graft-versus-host disease_Homo sapiens_hsa053320.72532068
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71499949
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70153064
89Rheumatoid arthritis_Homo sapiens_hsa053230.69916153
90Autoimmune thyroid disease_Homo sapiens_hsa053200.68639882
91Glutathione metabolism_Homo sapiens_hsa004800.68516206
92Colorectal cancer_Homo sapiens_hsa052100.68462352
93Caffeine metabolism_Homo sapiens_hsa002320.67471098
94Hematopoietic cell lineage_Homo sapiens_hsa046400.67049754
95Purine metabolism_Homo sapiens_hsa002300.66780190
96mRNA surveillance pathway_Homo sapiens_hsa030150.66609706
97Non-homologous end-joining_Homo sapiens_hsa034500.66317153
98Fatty acid elongation_Homo sapiens_hsa000620.66225525
99Systemic lupus erythematosus_Homo sapiens_hsa053220.65231812
100Epstein-Barr virus infection_Homo sapiens_hsa051690.64241230
101Fatty acid degradation_Homo sapiens_hsa000710.63770105
102Pyrimidine metabolism_Homo sapiens_hsa002400.61375321
103Wnt signaling pathway_Homo sapiens_hsa043100.61031350
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60461026
105p53 signaling pathway_Homo sapiens_hsa041150.59965673
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59732391
107Hedgehog signaling pathway_Homo sapiens_hsa043400.59719807
108Propanoate metabolism_Homo sapiens_hsa006400.59023182
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58012440
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57640911
111MicroRNAs in cancer_Homo sapiens_hsa052060.57521783
112Glutamatergic synapse_Homo sapiens_hsa047240.57286998
113Proteoglycans in cancer_Homo sapiens_hsa052050.57256473
114Glioma_Homo sapiens_hsa052140.57075319
115Metabolic pathways_Homo sapiens_hsa011000.55639742
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.54600619
117Viral myocarditis_Homo sapiens_hsa054160.53771858
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53596820
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.53381941
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53071343
121One carbon pool by folate_Homo sapiens_hsa006700.52448185
122ErbB signaling pathway_Homo sapiens_hsa040120.52288418
123Olfactory transduction_Homo sapiens_hsa047400.51992555
124beta-Alanine metabolism_Homo sapiens_hsa004100.51426743
125Taste transduction_Homo sapiens_hsa047420.51070443
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51011353
127Protein export_Homo sapiens_hsa030600.50968294
128Basal cell carcinoma_Homo sapiens_hsa052170.49498463
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48721901
130Renal cell carcinoma_Homo sapiens_hsa052110.48410298
131Cholinergic synapse_Homo sapiens_hsa047250.47806519
132Adherens junction_Homo sapiens_hsa045200.45864145
133Oxytocin signaling pathway_Homo sapiens_hsa049210.44567385
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44494110
135Type I diabetes mellitus_Homo sapiens_hsa049400.43539593
136HIF-1 signaling pathway_Homo sapiens_hsa040660.42398859
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42232566
138Melanogenesis_Homo sapiens_hsa049160.41991908
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38673494
140Herpes simplex infection_Homo sapiens_hsa051680.36389784
141Ether lipid metabolism_Homo sapiens_hsa005650.33585215
142N-Glycan biosynthesis_Homo sapiens_hsa005100.29594968
143Folate biosynthesis_Homo sapiens_hsa007900.28011159
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26154641
145Measles_Homo sapiens_hsa051620.25636895
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.23409718
147Vitamin B6 metabolism_Homo sapiens_hsa007500.22942000
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20844311
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20582974
150Nitrogen metabolism_Homo sapiens_hsa009100.16360822
151Shigellosis_Homo sapiens_hsa051310.15919342
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14439759

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