UBA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)6.37834289
2viral transcription (GO:0019083)5.84382161
3translational termination (GO:0006415)5.69993639
4ribosomal small subunit biogenesis (GO:0042274)5.55296024
5pore complex assembly (GO:0046931)5.48264328
6mitotic chromosome condensation (GO:0007076)5.37741486
7mitotic sister chromatid cohesion (GO:0007064)5.28274971
8translational elongation (GO:0006414)4.87547132
9sister chromatid segregation (GO:0000819)4.81861542
10mitotic sister chromatid segregation (GO:0000070)4.81803971
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.70980419
12ribosomal small subunit assembly (GO:0000028)4.70563829
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70194966
14cotranslational protein targeting to membrane (GO:0006613)4.63052519
15protein targeting to ER (GO:0045047)4.60188769
16translational initiation (GO:0006413)4.59619954
17establishment of integrated proviral latency (GO:0075713)4.59437379
18cellular protein complex disassembly (GO:0043624)4.58068920
19DNA replication initiation (GO:0006270)4.54378019
20DNA strand elongation involved in DNA replication (GO:0006271)4.48713061
21rRNA modification (GO:0000154)4.46844833
22viral life cycle (GO:0019058)4.40315851
23CENP-A containing nucleosome assembly (GO:0034080)4.39306153
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.38648210
25chromatin remodeling at centromere (GO:0031055)4.37539566
26telomere maintenance via semi-conservative replication (GO:0032201)4.29487538
27protein localization to endoplasmic reticulum (GO:0070972)4.28288278
28spliceosomal snRNP assembly (GO:0000387)4.26316386
29DNA strand elongation (GO:0022616)4.23516169
30ribonucleoprotein complex biogenesis (GO:0022613)4.20066361
31DNA unwinding involved in DNA replication (GO:0006268)4.18655474
32regulation of translational fidelity (GO:0006450)4.17433395
33cellular response to electrical stimulus (GO:0071257)4.14992358
34DNA topological change (GO:0006265)4.11723121
35ribosomal large subunit biogenesis (GO:0042273)4.07592068
36protein complex disassembly (GO:0043241)4.06583762
37regulation of helicase activity (GO:0051095)4.04655901
38spliceosomal complex assembly (GO:0000245)4.02637891
39detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.99741530
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.98592821
41nucleoside diphosphate catabolic process (GO:0009134)3.98304650
42formation of translation preinitiation complex (GO:0001731)3.97106792
43heterochromatin organization (GO:0070828)3.92620854
44mitotic metaphase plate congression (GO:0007080)3.90984576
45DNA synthesis involved in DNA repair (GO:0000731)3.86359905
46rRNA methylation (GO:0031167)3.84766923
47rRNA processing (GO:0006364)3.84387015
48DNA duplex unwinding (GO:0032508)3.84181415
49macromolecular complex disassembly (GO:0032984)3.84018996
50kinetochore organization (GO:0051383)3.83705855
51DNA replication-independent nucleosome organization (GO:0034724)3.80777145
52DNA replication-independent nucleosome assembly (GO:0006336)3.80777145
53ribosome biogenesis (GO:0042254)3.79878182
54telomere maintenance via recombination (GO:0000722)3.79593890
55kinetochore assembly (GO:0051382)3.79390705
56protein localization to kinetochore (GO:0034501)3.77612089
57histone exchange (GO:0043486)3.75289940
58DNA replication-dependent nucleosome organization (GO:0034723)3.73005887
59DNA replication-dependent nucleosome assembly (GO:0006335)3.73005887
60rRNA metabolic process (GO:0016072)3.70175394
61DNA geometric change (GO:0032392)3.69979541
62nucleobase biosynthetic process (GO:0046112)3.69728101
63translation (GO:0006412)3.69350826
64regulation of RNA export from nucleus (GO:0046831)3.69315596
65termination of RNA polymerase I transcription (GO:0006363)3.65462375
66mitotic recombination (GO:0006312)3.64167416
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.63072907
68DNA deamination (GO:0045006)3.60566813
69ribosome assembly (GO:0042255)3.58053958
70positive regulation of chromosome segregation (GO:0051984)3.56736841
71protein complex localization (GO:0031503)3.56609376
72regulation of sister chromatid cohesion (GO:0007063)3.53284183
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.53146220
74telomere maintenance via telomere lengthening (GO:0010833)3.50504333
75transcription-coupled nucleotide-excision repair (GO:0006283)3.50239123
76folic acid-containing compound biosynthetic process (GO:0009396)3.48288170
77cellular protein complex localization (GO:0034629)3.48135373
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48032106
79chromosome condensation (GO:0030261)3.47931765
80mitotic nuclear envelope disassembly (GO:0007077)3.47031322
81DNA replication checkpoint (GO:0000076)3.46210608
82double-strand break repair via nonhomologous end joining (GO:0006303)3.46176308
83non-recombinational repair (GO:0000726)3.46176308
84establishment of viral latency (GO:0019043)3.43806988
85DNA conformation change (GO:0071103)3.43358044
86mRNA catabolic process (GO:0006402)3.42978212
87negative regulation of RNA splicing (GO:0033119)3.40955317
88transcription elongation from RNA polymerase I promoter (GO:0006362)3.39904137
89regulation of centriole replication (GO:0046599)3.38540460
90metaphase plate congression (GO:0051310)3.36091078
917-methylguanosine mRNA capping (GO:0006370)3.35475038
92RNA catabolic process (GO:0006401)3.33837752
93histone H4-K5 acetylation (GO:0043981)3.33169932
94histone H4-K8 acetylation (GO:0043982)3.33169932
95transcription from RNA polymerase I promoter (GO:0006360)3.32458594
96termination of RNA polymerase III transcription (GO:0006386)3.31703931
97transcription elongation from RNA polymerase III promoter (GO:0006385)3.31703931
98pre-miRNA processing (GO:0031054)3.31146174
99regulation of chromosome segregation (GO:0051983)3.31118756
100regulation of nuclear cell cycle DNA replication (GO:0033262)3.30676293
101IMP metabolic process (GO:0046040)3.30109371
102regulation of histone H3-K9 methylation (GO:0051570)3.30108264
103meiotic chromosome segregation (GO:0045132)3.29825330
104RNA capping (GO:0036260)3.29506697
1057-methylguanosine RNA capping (GO:0009452)3.29506697
106purine nucleobase biosynthetic process (GO:0009113)3.28605468
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27815215
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26910457
109negative regulation of DNA repair (GO:0045738)3.25431583
110establishment of protein localization to mitochondrial membrane (GO:0090151)3.23454447
111nuclear pore organization (GO:0006999)3.21681972
112DNA packaging (GO:0006323)3.20917152
113membrane disassembly (GO:0030397)3.20737997
114nuclear envelope disassembly (GO:0051081)3.20737997
115pseudouridine synthesis (GO:0001522)3.20580178
116negative regulation of chromosome segregation (GO:0051985)3.19686709
117nuclear envelope organization (GO:0006998)3.18283151
118paraxial mesoderm development (GO:0048339)3.17586537
119DNA-templated transcription, termination (GO:0006353)3.15360768
120transcription initiation from RNA polymerase I promoter (GO:0006361)3.15351767
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14324649
122termination of RNA polymerase II transcription (GO:0006369)3.13865030
123negative regulation of mRNA processing (GO:0050686)3.13645421
124protein localization to chromosome, centromeric region (GO:0071459)3.13200353
125cell migration involved in gastrulation (GO:0042074)3.13008267
126spliceosomal tri-snRNP complex assembly (GO:0000244)3.11014263
127chromatin assembly or disassembly (GO:0006333)3.10883688
128chromatin assembly (GO:0031497)3.10381114
129IMP biosynthetic process (GO:0006188)3.09868624
130ATP-dependent chromatin remodeling (GO:0043044)3.08601424
131cellular component biogenesis (GO:0044085)3.07897576
132chromosome segregation (GO:0007059)3.05255878
133negative regulation of mitotic sister chromatid separation (GO:2000816)3.04615495
134negative regulation of sister chromatid segregation (GO:0033046)3.04615495
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04615495
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04615495
137negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04615495
138nuclear pore complex assembly (GO:0051292)3.03252636
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03091188
140mRNA splicing, via spliceosome (GO:0000398)3.03091188
141regulation of posttranscriptional gene silencing (GO:0060147)3.02932047
142regulation of gene silencing by miRNA (GO:0060964)3.02932047
143regulation of gene silencing by RNA (GO:0060966)3.02932047
144sister chromatid cohesion (GO:0007062)3.02709374
145regulation of centrosome cycle (GO:0046605)3.02598103
146protein localization to chromosome (GO:0034502)3.02171239
147positive regulation of cell cycle checkpoint (GO:1901978)3.02040635
148spindle checkpoint (GO:0031577)3.01993312
149regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00646112
150regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00646112
151regulation of mitotic sister chromatid separation (GO:0010965)3.00486119
152regulation of mitotic sister chromatid segregation (GO:0033047)3.00486119
153regulation of sister chromatid segregation (GO:0033045)3.00486119
154mitotic spindle checkpoint (GO:0071174)2.98987086
155negative regulation of mRNA metabolic process (GO:1903312)2.98944732
156mRNA transport (GO:0051028)2.98564439
157mitotic spindle assembly checkpoint (GO:0007094)2.98231673
158regulation of nucleobase-containing compound transport (GO:0032239)2.97861736
159regulation of DNA endoreduplication (GO:0032875)2.97552170
160DNA ligation (GO:0006266)2.93960533
161spindle assembly checkpoint (GO:0071173)2.93628459
162establishment of chromosome localization (GO:0051303)2.93555661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.01317096
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.83387877
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.66334159
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64561743
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64079340
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.54932044
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49161497
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.28273815
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09306980
10MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04639935
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.03587035
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.99810211
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92842604
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87258487
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75216647
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74210456
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70301727
18XRN2_22483619_ChIP-Seq_HELA_Human2.55826162
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48113733
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47679185
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34294689
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32612143
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31282207
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24471824
25VDR_23849224_ChIP-Seq_CD4+_Human2.17866379
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14226509
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13897106
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07861385
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07425891
30FOXP3_21729870_ChIP-Seq_TREG_Human2.05971213
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.05787568
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03479680
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98767942
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.96306741
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93258446
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93258446
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93258446
38AR_21909140_ChIP-Seq_LNCAP_Human1.93180862
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92777031
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90482112
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86662846
42* TTF2_22483619_ChIP-Seq_HELA_Human1.85566836
43ELK1_19687146_ChIP-ChIP_HELA_Human1.84320345
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82827062
45DCP1A_22483619_ChIP-Seq_HELA_Human1.81911910
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80061786
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78841316
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.78121134
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.73614274
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67537876
51MYC_22102868_ChIP-Seq_BL_Human1.67247577
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66987788
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66438557
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65381225
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62647783
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62169784
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60123858
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53140373
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52954375
60* GABP_19822575_ChIP-Seq_HepG2_Human1.51795760
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49598706
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.42092505
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40691102
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37700312
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34218488
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32009586
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31073567
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30861414
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30829182
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30131781
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.28347507
72* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28154122
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27372413
74* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26110549
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26094327
76ZNF263_19887448_ChIP-Seq_K562_Human1.25941505
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24988834
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24105855
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21047622
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.18716222
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18335098
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.17921029
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.17243015
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15753000
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13676341
86KDM5A_27292631_Chip-Seq_BREAST_Human1.13672183
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13005448
88CIITA_25753668_ChIP-Seq_RAJI_Human1.12003192
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11909860
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10582545
91CHD1_26751641_Chip-Seq_LNCaP_Human1.09044240
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08190395
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07137584
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04782907
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04592253
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03501748
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.03074288
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03068825
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.02777476
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02096901
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01840818
102POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00607154
103MYC_18940864_ChIP-ChIP_HL60_Human0.98942469
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97431849
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95863508
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95297468
107CLOCK_20551151_ChIP-Seq_293T_Human0.95286392
108NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94940539
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.92938033
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92349356
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89544914
112ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88987272
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86543919
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86057299
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.85964363
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85832944
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84435871
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.84249705
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83734645
120IRF1_19129219_ChIP-ChIP_H3396_Human0.83700031
121TFEB_21752829_ChIP-Seq_HELA_Human0.83647915
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83413978
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.82399027
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82230953
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79880398
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78677910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.05263167
2MP0005423_abnormal_somatic_nervous5.44978179
3MP0003693_abnormal_embryo_hatching4.54280469
4MP0009379_abnormal_foot_pigmentation4.43541104
5MP0004957_abnormal_blastocyst_morpholog4.07846805
6MP0008057_abnormal_DNA_replication3.92543945
7MP0003111_abnormal_nucleus_morphology3.82902351
8MP0010094_abnormal_chromosome_stability3.70548548
9MP0003077_abnormal_cell_cycle3.40622400
10MP0004145_abnormal_muscle_electrophysio3.17819091
11MP0008058_abnormal_DNA_repair3.01519054
12MP0002009_preneoplasia2.77755781
13MP0003136_yellow_coat_color2.65319195
14MP0003806_abnormal_nucleotide_metabolis2.56564270
15MP0003123_paternal_imprinting2.53303716
16MP0000566_synostosis2.46213450
17MP0006292_abnormal_olfactory_placode2.45380009
18MP0008932_abnormal_embryonic_tissue2.43154803
19MP0008007_abnormal_cellular_replicative2.38655672
20MP0004133_heterotaxia2.34865920
21MP0002877_abnormal_melanocyte_morpholog2.26976948
22MP0004185_abnormal_adipocyte_glucose2.18994745
23MP0001730_embryonic_growth_arrest2.03224652
24MP0000350_abnormal_cell_proliferation1.84988062
25MP0009672_abnormal_birth_weight1.84590617
26MP0003890_abnormal_embryonic-extraembry1.84429140
27MP0003705_abnormal_hypodermis_morpholog1.82955819
28MP0009697_abnormal_copulation1.81584662
29MP0008877_abnormal_DNA_methylation1.65969613
30MP0003718_maternal_effect1.63082853
31MP0002085_abnormal_embryonic_tissue1.53269614
32MP0010352_gastrointestinal_tract_polyps1.51618103
33MP0003786_premature_aging1.50445746
34MP0003283_abnormal_digestive_organ1.44826495
35MP0002084_abnormal_developmental_patter1.42612936
36MP0010234_abnormal_vibrissa_follicle1.40949790
37MP0005380_embryogenesis_phenotype1.38603355
38MP0001672_abnormal_embryogenesis/_devel1.38603355
39MP0001697_abnormal_embryo_size1.38558322
40MP0001661_extended_life_span1.37682733
41MP0002080_prenatal_lethality1.36231276
42MP0002210_abnormal_sex_determination1.32760280
43MP0003121_genomic_imprinting1.30668644
44MP0010307_abnormal_tumor_latency1.30508402
45MP0004197_abnormal_fetal_growth/weight/1.24948261
46MP0004233_abnormal_muscle_weight1.23083087
47MP0010030_abnormal_orbit_morphology1.22666754
48MP0001293_anophthalmia1.22128255
49MP0003941_abnormal_skin_development1.21190423
50MP0003984_embryonic_growth_retardation1.17356039
51MP0003221_abnormal_cardiomyocyte_apopto1.14903136
52MP0002088_abnormal_embryonic_growth/wei1.13818066
53MP0001145_abnormal_male_reproductive1.12885509
54MP0000313_abnormal_cell_death1.11025390
55MP0003045_fibrosis1.09734364
56MP0002086_abnormal_extraembryonic_tissu1.09714500
57MP0003385_abnormal_body_wall1.08127277
58MP0005666_abnormal_adipose_tissue1.05303657
59MP0003942_abnormal_urinary_system1.02916604
60MP0001346_abnormal_lacrimal_gland1.01956193
61MP0001929_abnormal_gametogenesis0.98635729
62MP0003119_abnormal_digestive_system0.98606333
63MP0003567_abnormal_fetal_cardiomyocyte0.96221521
64MP0005623_abnormal_meninges_morphology0.96073299
65MP0000653_abnormal_sex_gland0.95627106
66MP0005187_abnormal_penis_morphology0.94987819
67MP0001915_intracranial_hemorrhage0.94383934
68MP0003950_abnormal_plasma_membrane0.90056713
69MP0005253_abnormal_eye_physiology0.87883850
70MP0002019_abnormal_tumor_incidence0.87636967
71MP0003115_abnormal_respiratory_system0.87290596
72MP0001299_abnormal_eye_distance/0.86416033
73MP0000537_abnormal_urethra_morphology0.86266947
74MP0005391_vision/eye_phenotype0.85046879
75MP0003937_abnormal_limbs/digits/tail_de0.84315156
76MP0009053_abnormal_anal_canal0.84116955
77MP0006072_abnormal_retinal_apoptosis0.83396721
78MP0005395_other_phenotype0.82829066
79MP0005501_abnormal_skin_physiology0.82553537
80MP0001286_abnormal_eye_development0.81669548
81MP0005076_abnormal_cell_differentiation0.81611903
82MP0002396_abnormal_hematopoietic_system0.81191229
83MP0002653_abnormal_ependyma_morphology0.79934798
84MP0008789_abnormal_olfactory_epithelium0.78776355
85MP0003943_abnormal_hepatobiliary_system0.77926353
86MP0000490_abnormal_crypts_of0.77709183
87MP0002114_abnormal_axial_skeleton0.76878092
88MP0002796_impaired_skin_barrier0.76195531
89MP0005621_abnormal_cell_physiology0.76098506
90MP0000762_abnormal_tongue_morphology0.75733306
91MP0005408_hypopigmentation0.74639040
92MP0000733_abnormal_muscle_development0.74570866
93MP0002081_perinatal_lethality0.73240495
94MP0009703_decreased_birth_body0.73167058
95MP0010630_abnormal_cardiac_muscle0.72817242
96MP0002111_abnormal_tail_morphology0.71797058
97MP0008995_early_reproductive_senescence0.70855968
98MP0003861_abnormal_nervous_system0.69896234
99MP0002751_abnormal_autonomic_nervous0.69459835
100MP0003566_abnormal_cell_adhesion0.67968291
101MP0000358_abnormal_cell_content/0.67543702
102MP0001529_abnormal_vocalization0.67424659
103MP0002092_abnormal_eye_morphology0.67272192
104MP0002160_abnormal_reproductive_system0.66708962
105MP0005389_reproductive_system_phenotype0.66628540
106MP0003315_abnormal_perineum_morphology0.66519106
107MP0000579_abnormal_nail_morphology0.64838963
108MP0002249_abnormal_larynx_morphology0.63775051
109MP0004272_abnormal_basement_membrane0.63572287
110MP0003938_abnormal_ear_development0.63488989
111MP0005375_adipose_tissue_phenotype0.63298691
112MP0006035_abnormal_mitochondrial_morpho0.63179995
113MP0003698_abnormal_male_reproductive0.62006166
114MP0001188_hyperpigmentation0.61177921
115MP0002938_white_spotting0.60638765
116MP0005266_abnormal_metabolism0.60322972
117MP0002697_abnormal_eye_size0.59502333
118MP0002102_abnormal_ear_morphology0.58911812
119MP0000372_irregular_coat_pigmentation0.58848557
120MP0000703_abnormal_thymus_morphology0.58427799
121MP0002163_abnormal_gland_morphology0.58181769
122MP0000432_abnormal_head_morphology0.57619790
123MP0003755_abnormal_palate_morphology0.54115992
124MP0005384_cellular_phenotype0.53676984
125MP0005394_taste/olfaction_phenotype0.52106330
126MP0005499_abnormal_olfactory_system0.52106330
127MP0000428_abnormal_craniofacial_morphol0.51677599
128MP0001727_abnormal_embryo_implantation0.51207747
129MP0001919_abnormal_reproductive_system0.49687843
130MP0008770_decreased_survivor_rate0.49198740
131MP0004808_abnormal_hematopoietic_stem0.48455994
132MP0002233_abnormal_nose_morphology0.48102523
133MP0001119_abnormal_female_reproductive0.48026291
134MP0003935_abnormal_craniofacial_develop0.47431319

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)8.51076185
2Abnormality of the renal collecting system (HP:0004742)7.31514039
3Long foot (HP:0001833)6.31471816
4Acute lymphatic leukemia (HP:0006721)5.97388206
5Breast hypoplasia (HP:0003187)5.22287734
6Adactyly (HP:0009776)5.01388220
7Congenital stationary night blindness (HP:0007642)4.98826825
8Reticulocytopenia (HP:0001896)4.94041792
9Hypoplastic nipples (HP:0002557)4.90586912
10Abnormality of cells of the erythroid lineage (HP:0012130)4.71025261
11Birth length less than 3rd percentile (HP:0003561)4.31469683
12Ureteral duplication (HP:0000073)4.28811576
13Large for gestational age (HP:0001520)4.18219829
14Abnormal number of erythroid precursors (HP:0012131)4.17264855
15Pulmonary artery stenosis (HP:0004415)3.88442224
16Colon cancer (HP:0003003)3.68860678
17Macrocytic anemia (HP:0001972)3.67431700
18Increased nuchal translucency (HP:0010880)3.53231613
19Abnormal connection of the cardiac segments (HP:0011545)3.50776317
20Abnormal ventriculo-arterial connection (HP:0011563)3.50776317
21Transposition of the great arteries (HP:0001669)3.50776317
22Ureteral stenosis (HP:0000071)3.35418892
23Abnormality of the labia minora (HP:0012880)3.23852319
24Cortical dysplasia (HP:0002539)3.23081615
25Selective tooth agenesis (HP:0001592)3.21383148
26Pallor (HP:0000980)3.18131471
27Nephroblastoma (Wilms tumor) (HP:0002667)2.99889740
28Ureteral obstruction (HP:0006000)2.99754472
29Abdominal situs inversus (HP:0003363)2.94793976
30Abnormality of abdominal situs (HP:0011620)2.94793976
31Oral leukoplakia (HP:0002745)2.88385755
32Volvulus (HP:0002580)2.85708009
33Aplasia/Hypoplasia of the nipples (HP:0006709)2.84244719
34Embryonal renal neoplasm (HP:0011794)2.80697227
35Broad-based gait (HP:0002136)2.77143365
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76911852
37Ependymoma (HP:0002888)2.76772150
38Clubbing of toes (HP:0100760)2.73913264
39Supernumerary spleens (HP:0009799)2.60994675
40Patellar aplasia (HP:0006443)2.56858924
41Rough bone trabeculation (HP:0100670)2.56725113
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54555076
43Absent radius (HP:0003974)2.54231470
44Abnormality of cochlea (HP:0000375)2.53967133
45Deviation of the thumb (HP:0009603)2.53022430
46Medulloblastoma (HP:0002885)2.53009988
47Cerebral hypomyelination (HP:0006808)2.52821479
48Abnormal lung lobation (HP:0002101)2.52130920
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50857493
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50857493
51Chromsome breakage (HP:0040012)2.50736213
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46318942
53Absent forearm bone (HP:0003953)2.42340535
54Aplasia involving forearm bones (HP:0009822)2.42340535
55Microvesicular hepatic steatosis (HP:0001414)2.39901636
56Carpal bone hypoplasia (HP:0001498)2.38774922
57Aplasia/Hypoplasia of the patella (HP:0006498)2.38338592
58Pendular nystagmus (HP:0012043)2.37320140
59Large hands (HP:0001176)2.32735973
60Deep philtrum (HP:0002002)2.31225452
61Increased number of teeth (HP:0011069)2.30745300
62Agnosia (HP:0010524)2.29694833
63Cafe-au-lait spot (HP:0000957)2.29325704
6411 pairs of ribs (HP:0000878)2.29192662
65Multiple enchondromatosis (HP:0005701)2.27901768
66High anterior hairline (HP:0009890)2.24511773
67Duplication of thumb phalanx (HP:0009942)2.23378379
68Abnormal number of incisors (HP:0011064)2.22094028
69Depressed nasal ridge (HP:0000457)2.20505799
70Overlapping toe (HP:0001845)2.20215622
71Absent thumb (HP:0009777)2.18860897
72Abnormality of chromosome stability (HP:0003220)2.18143353
73Ectopic kidney (HP:0000086)2.16551126
74Meckel diverticulum (HP:0002245)2.15751777
75Abnormality of the calcaneus (HP:0008364)2.15088668
76Abnormality of the carotid arteries (HP:0005344)2.14661236
77Missing ribs (HP:0000921)2.13667206
78Increased intramyocellular lipid droplets (HP:0012240)2.10987199
79Ankyloglossia (HP:0010296)2.09760111
80Abnormality of the preputium (HP:0100587)2.09749332
81Overfolded helix (HP:0000396)2.06919139
82Premature graying of hair (HP:0002216)2.06670220
83Septate vagina (HP:0001153)2.05763222
84Abnormality of the ileum (HP:0001549)2.04996853
85Abnormality of chromosome segregation (HP:0002916)2.04889197
86Aplastic anemia (HP:0001915)2.02597098
87Supernumerary bones of the axial skeleton (HP:0009144)2.00764766
88Hyperacusis (HP:0010780)2.00631962
89Termporal pattern (HP:0011008)2.00576855
90Insidious onset (HP:0003587)2.00576855
91Shoulder girdle muscle weakness (HP:0003547)2.00341526
92Horseshoe kidney (HP:0000085)1.99841595
93Neoplasm of the pancreas (HP:0002894)1.98981932
94Tracheoesophageal fistula (HP:0002575)1.98401303
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.95832840
96Malignant gastrointestinal tract tumors (HP:0006749)1.95557022
97Gastrointestinal carcinoma (HP:0002672)1.95557022
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94601599
99Embryonal neoplasm (HP:0002898)1.93772892
100Progressive muscle weakness (HP:0003323)1.92276949
101Facial cleft (HP:0002006)1.91365805
102Degeneration of anterior horn cells (HP:0002398)1.90901355
103Abnormality of the anterior horn cell (HP:0006802)1.90901355
104Aplasia/Hypoplasia of the breasts (HP:0010311)1.90438014
105Abnormally folded helix (HP:0008544)1.90333324
106Choanal atresia (HP:0000453)1.90079322
107Breast aplasia (HP:0100783)1.89722081
108Stenosis of the external auditory canal (HP:0000402)1.86675272
109Abnormality of the duodenum (HP:0002246)1.86621398
110Myelodysplasia (HP:0002863)1.86244911
111Acute myeloid leukemia (HP:0004808)1.85972428
112Obsessive-compulsive behavior (HP:0000722)1.85936028
113Asymmetry of the thorax (HP:0001555)1.85011647
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85008704
115Uterine leiomyosarcoma (HP:0002891)1.84356985
116Leiomyosarcoma (HP:0100243)1.84356985
117Urethral obstruction (HP:0000796)1.83357517
118Absent toe (HP:0010760)1.82939851
119Rhabdomyosarcoma (HP:0002859)1.82864052
120Proximal placement of thumb (HP:0009623)1.82319408
121Thick lower lip vermilion (HP:0000179)1.81950636
122Insomnia (HP:0100785)1.81127071
123Dysmetric saccades (HP:0000641)1.80931840
124Short middle phalanx of the 5th finger (HP:0004220)1.80805834
125Neoplasm of the oral cavity (HP:0100649)1.80751876
126Progressive external ophthalmoplegia (HP:0000590)1.80507408
127Morphological abnormality of the inner ear (HP:0011390)1.80198009
128Small intestinal stenosis (HP:0012848)1.78477837
129Duodenal stenosis (HP:0100867)1.78477837
130Atresia of the external auditory canal (HP:0000413)1.78023010
131Asplenia (HP:0001746)1.77384096
132Spastic diplegia (HP:0001264)1.77132355
133Arteriovenous malformation (HP:0100026)1.76658771
134Overriding aorta (HP:0002623)1.76487612
135Relative macrocephaly (HP:0004482)1.76331424
136Triphalangeal thumb (HP:0001199)1.75743710
137Septo-optic dysplasia (HP:0100842)1.75486427
138Spinal cord lesions (HP:0100561)1.75447117
139Syringomyelia (HP:0003396)1.75447117
140Tetralogy of Fallot (HP:0001636)1.74280505
141Cellular immunodeficiency (HP:0005374)1.73893251
142Aplasia/Hypoplasia of the sternum (HP:0006714)1.73809867
143Impulsivity (HP:0100710)1.73484815
144Abnormal trabecular bone morphology (HP:0100671)1.73363485
145Abnormality of the astrocytes (HP:0100707)1.72023974
146Astrocytoma (HP:0009592)1.72023974
147Supernumerary ribs (HP:0005815)1.71405024
148Calcaneovalgus deformity (HP:0001848)1.70420188
149Sandal gap (HP:0001852)1.70064852
150Neoplasm of the colon (HP:0100273)1.69398479
151Abnormality of the phalanges of the hallux (HP:0010057)1.69265611
152Heterotopia (HP:0002282)1.64734171
153Abnormality of oral frenula (HP:0000190)1.62494296
154Broad distal phalanx of finger (HP:0009836)1.60983852
155Skull defect (HP:0001362)1.58834566
156Sloping forehead (HP:0000340)1.58622835
157Abnormality of reticulocytes (HP:0004312)1.58381140
158Papillary thyroid carcinoma (HP:0002895)1.58253444
159Abnormality of glycolysis (HP:0004366)1.58251203
160Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58007748
161Deep palmar crease (HP:0006191)1.57801098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.57739662
2BUB14.44988976
3CDC74.21069885
4NME23.15691375
5SRPK13.14383724
6NEK12.95955264
7EIF2AK12.73361568
8TRIB32.63001594
9CDC42BPA2.59646207
10VRK12.55667300
11EIF2AK32.47908786
12TTK2.42493664
13RPS6KB22.39108529
14NEK22.34250498
15STK162.15596972
16DYRK32.00931367
17PLK12.00538553
18EPHA21.99505565
19SMG11.93817995
20CDK71.90549843
21MKNK11.80871959
22ATR1.79499146
23ACVR1B1.72836444
24PAK41.71923969
25TAF11.65734218
26TESK21.64218889
27AURKB1.59621384
28TLK11.52475408
29MKNK21.50928658
30PLK31.44765257
31MAP3K81.44681033
32ICK1.41839019
33AURKA1.39515681
34BRSK21.38303042
35CHEK11.38079399
36TSSK61.34914512
37MST41.34075770
38CAMK1G1.30191413
39CLK11.29814393
40LATS11.28521081
41CHEK21.26909671
42CDK121.20751680
43PDGFRA1.14705720
44PASK1.13115435
45ROCK21.09363961
46PLK41.08727872
47IRAK31.05729339
48BRD41.01384000
49CSNK2A20.99622225
50PBK0.98549661
51PNCK0.95446650
52ALK0.93083695
53PAK10.92745698
54ATM0.92268061
55KSR20.90922693
56CDK20.90910697
57CCNB10.90848775
58CDK40.89818606
59STK100.89746432
60BRSK10.89423181
61MAPKAPK30.89228105
62EIF2AK20.86296347
63EEF2K0.80908934
64DYRK20.79668840
65STK240.79436390
66CAMK1D0.78549591
67CSNK2A10.77839300
68PRKCI0.77155048
69STK30.76542466
70CDK10.74855790
71SCYL20.73217119
72PRPF4B0.69741461
73KSR10.67086367
74CSNK1E0.64884770
75ABL20.64678620
76CDK30.63583482
77FGFR10.63046516
78RPS6KA40.59375458
79NME10.59341522
80TGFBR10.58576698
81MAP3K90.58534609
82LRRK20.57567229
83STK40.57456181
84NEK90.55566104
85PKN20.55533973
86LATS20.51760349
87CSNK1D0.51712651
88PIM10.51705596
89MELK0.49973021
90TYRO30.49727653
91ERBB40.49055653
92MET0.47913430
93RAF10.47301349
94FLT30.47284434
95RPS6KB10.45459092
96MTOR0.44945981
97ROCK10.44896748
98CDK190.44332456
99CDK90.43661686
100RPS6KA50.41552235
101TTN0.40614697
102CDK11A0.40517943
103BRAF0.39178731
104PRKDC0.36872363
105CDK150.35447530
106PAK20.33525667
107CDK180.32895456
108STK38L0.32761758
109DMPK0.32320522
110CDK140.32308459
111GRK60.32144276
112MAPK100.31436450
113CSNK1G30.30947590
114MAP3K100.30678618
115ZAK0.30531029
116CDK80.30410743
117UHMK10.29517963
118NEK60.25781494
119YES10.24810507
120AKT30.24041099
121CDK60.23607884
122MAPK140.23270975
123GSK3B0.20952246
124BCR0.20908346
125CSNK1G10.19912635
126LIMK10.19700820
127AKT20.18714720
128ILK0.18108436
129DAPK30.17846456

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.51406620
2DNA replication_Homo sapiens_hsa030304.81672835
3Mismatch repair_Homo sapiens_hsa034304.38146401
4RNA polymerase_Homo sapiens_hsa030203.96679340
5Spliceosome_Homo sapiens_hsa030403.81611325
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73517869
7Proteasome_Homo sapiens_hsa030503.17147926
8RNA transport_Homo sapiens_hsa030133.16219448
9Nucleotide excision repair_Homo sapiens_hsa034202.98831208
10Pyrimidine metabolism_Homo sapiens_hsa002402.88209189
11Fanconi anemia pathway_Homo sapiens_hsa034602.77846838
12Homologous recombination_Homo sapiens_hsa034402.72554379
13Base excision repair_Homo sapiens_hsa034102.52067087
14One carbon pool by folate_Homo sapiens_hsa006702.50577237
15Cell cycle_Homo sapiens_hsa041102.33648341
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22245781
17RNA degradation_Homo sapiens_hsa030182.02562899
18Basal transcription factors_Homo sapiens_hsa030221.96929167
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89733281
20Non-homologous end-joining_Homo sapiens_hsa034501.81334403
21Phototransduction_Homo sapiens_hsa047441.75643953
22mRNA surveillance pathway_Homo sapiens_hsa030151.72210715
23Purine metabolism_Homo sapiens_hsa002301.63317532
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56038391
25Epstein-Barr virus infection_Homo sapiens_hsa051691.27999346
26Huntingtons disease_Homo sapiens_hsa050161.27365160
27p53 signaling pathway_Homo sapiens_hsa041151.23050403
28Oxidative phosphorylation_Homo sapiens_hsa001901.20879915
29Parkinsons disease_Homo sapiens_hsa050121.18878767
30Systemic lupus erythematosus_Homo sapiens_hsa053221.13110017
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11325709
32Lysine degradation_Homo sapiens_hsa003101.04174809
33Oocyte meiosis_Homo sapiens_hsa041141.03419227
34Pyruvate metabolism_Homo sapiens_hsa006201.01029806
35Pancreatic cancer_Homo sapiens_hsa052121.00930051
36Non-small cell lung cancer_Homo sapiens_hsa052230.97551302
37Protein export_Homo sapiens_hsa030600.96518081
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89669521
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82785466
40Viral carcinogenesis_Homo sapiens_hsa052030.76127279
41Glioma_Homo sapiens_hsa052140.75773665
42Endometrial cancer_Homo sapiens_hsa052130.74479467
43Vitamin B6 metabolism_Homo sapiens_hsa007500.74363726
44* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73844548
45Renal cell carcinoma_Homo sapiens_hsa052110.73360781
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72265411
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68159098
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.66999174
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63971842
50N-Glycan biosynthesis_Homo sapiens_hsa005100.62785233
51Alzheimers disease_Homo sapiens_hsa050100.62698849
52ErbB signaling pathway_Homo sapiens_hsa040120.62428064
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.61767276
54AMPK signaling pathway_Homo sapiens_hsa041520.58289916
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58262383
56Biosynthesis of amino acids_Homo sapiens_hsa012300.58004271
57Insulin signaling pathway_Homo sapiens_hsa049100.57850832
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56002345
59Glutathione metabolism_Homo sapiens_hsa004800.54193143
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54115281
61mTOR signaling pathway_Homo sapiens_hsa041500.53466605
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.51514581
63Acute myeloid leukemia_Homo sapiens_hsa052210.50661448
64Steroid biosynthesis_Homo sapiens_hsa001000.49278605
65Proteoglycans in cancer_Homo sapiens_hsa052050.48996415
66Alcoholism_Homo sapiens_hsa050340.47943290
67Folate biosynthesis_Homo sapiens_hsa007900.47940790
68Herpes simplex infection_Homo sapiens_hsa051680.47758600
69HTLV-I infection_Homo sapiens_hsa051660.46977986
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46489856
71Small cell lung cancer_Homo sapiens_hsa052220.43107234
72MicroRNAs in cancer_Homo sapiens_hsa052060.40877854
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39731888
74Basal cell carcinoma_Homo sapiens_hsa052170.36882910
75Notch signaling pathway_Homo sapiens_hsa043300.36109515
76TGF-beta signaling pathway_Homo sapiens_hsa043500.35585237
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35215707
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.34928348
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34359140
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33453476
81Selenocompound metabolism_Homo sapiens_hsa004500.33013300
82Colorectal cancer_Homo sapiens_hsa052100.30545921
83VEGF signaling pathway_Homo sapiens_hsa043700.30324618
84Propanoate metabolism_Homo sapiens_hsa006400.29872408
85Pentose phosphate pathway_Homo sapiens_hsa000300.29807849
86Hippo signaling pathway_Homo sapiens_hsa043900.27558487
87Sulfur relay system_Homo sapiens_hsa041220.27256873
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27096641
89FoxO signaling pathway_Homo sapiens_hsa040680.27044854
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26771967
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26768552
92Choline metabolism in cancer_Homo sapiens_hsa052310.26528529
93Metabolic pathways_Homo sapiens_hsa011000.25726569
94Glucagon signaling pathway_Homo sapiens_hsa049220.25454340
95Fatty acid biosynthesis_Homo sapiens_hsa000610.25288838
96Arginine and proline metabolism_Homo sapiens_hsa003300.24704251
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22375371
98Wnt signaling pathway_Homo sapiens_hsa043100.22037876
99Antigen processing and presentation_Homo sapiens_hsa046120.21198215
100Pathways in cancer_Homo sapiens_hsa052000.20165263
101Thyroid cancer_Homo sapiens_hsa052160.16570888
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15526116
103Apoptosis_Homo sapiens_hsa042100.15358348
104Shigellosis_Homo sapiens_hsa051310.14156679
105Carbon metabolism_Homo sapiens_hsa012000.13783094
106Cardiac muscle contraction_Homo sapiens_hsa042600.13077932
107Hedgehog signaling pathway_Homo sapiens_hsa043400.12748926
108Renin-angiotensin system_Homo sapiens_hsa046140.11888848
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11495711
110Tight junction_Homo sapiens_hsa045300.08842646
111Primary immunodeficiency_Homo sapiens_hsa053400.08736479
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.08627444
113HIF-1 signaling pathway_Homo sapiens_hsa040660.08546841
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08122924
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06171523
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.04275782
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00472627
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0704551
119NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0688456
120Adherens junction_Homo sapiens_hsa04520-0.0646825
121NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0637780
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0626656
123Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0528550
124PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0318898
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0308636
126Prostate cancer_Homo sapiens_hsa05215-0.0276095
127Melanoma_Homo sapiens_hsa05218-0.0206552
128Bladder cancer_Homo sapiens_hsa05219-0.0095446
129Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0071635
130Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0063879
131Hepatitis B_Homo sapiens_hsa05161-0.0040306
132Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0018439

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