U2SURP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.00405071
2nuclear pore complex assembly (GO:0051292)4.75033157
3nuclear pore organization (GO:0006999)4.51318612
4regulation of DNA endoreduplication (GO:0032875)4.36816835
5mitotic sister chromatid cohesion (GO:0007064)4.33796980
6kinetochore assembly (GO:0051382)4.31543040
7DNA unwinding involved in DNA replication (GO:0006268)4.12587069
8chromatin remodeling at centromere (GO:0031055)4.01888778
9CENP-A containing nucleosome assembly (GO:0034080)3.94711615
10DNA replication initiation (GO:0006270)3.92162507
11ribosome assembly (GO:0042255)3.83117940
12mitotic chromosome condensation (GO:0007076)3.82524577
13non-recombinational repair (GO:0000726)3.80563662
14double-strand break repair via nonhomologous end joining (GO:0006303)3.80563662
15DNA double-strand break processing (GO:0000729)3.80474404
16DNA replication-independent nucleosome assembly (GO:0006336)3.70727645
17DNA replication-independent nucleosome organization (GO:0034724)3.70727645
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.67511742
19sister chromatid segregation (GO:0000819)3.65515153
20regulation of helicase activity (GO:0051095)3.65254806
21DNA strand elongation involved in DNA replication (GO:0006271)3.63928471
22protein localization to kinetochore (GO:0034501)3.58714541
23mitotic metaphase plate congression (GO:0007080)3.56997430
24mitotic recombination (GO:0006312)3.55754675
25DNA replication checkpoint (GO:0000076)3.55375339
26pore complex assembly (GO:0046931)3.54863502
27mitotic spindle checkpoint (GO:0071174)3.54542343
28DNA strand renaturation (GO:0000733)3.53554145
29intra-S DNA damage checkpoint (GO:0031573)3.51828249
30mitotic sister chromatid segregation (GO:0000070)3.51633928
31telomere maintenance via semi-conservative replication (GO:0032201)3.50716535
32DNA strand elongation (GO:0022616)3.46676921
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46443695
34metaphase plate congression (GO:0051310)3.45409615
35regulation of centriole replication (GO:0046599)3.42472244
36histone exchange (GO:0043486)3.38355499
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.38324516
38telomere maintenance via recombination (GO:0000722)3.37784807
39attachment of spindle microtubules to kinetochore (GO:0008608)3.37183739
40ribosomal large subunit biogenesis (GO:0042273)3.30280475
41replication fork processing (GO:0031297)3.29556547
42regulation of RNA export from nucleus (GO:0046831)3.29369995
43mitotic G2/M transition checkpoint (GO:0044818)3.29176114
44meiotic chromosome segregation (GO:0045132)3.25362571
45DNA replication-dependent nucleosome assembly (GO:0006335)3.23336470
46DNA replication-dependent nucleosome organization (GO:0034723)3.23336470
47DNA geometric change (GO:0032392)3.23035133
48regulation of histone H3-K9 methylation (GO:0051570)3.22888678
49heterochromatin organization (GO:0070828)3.22436065
50DNA duplex unwinding (GO:0032508)3.22003595
51regulation of centrosome cycle (GO:0046605)3.21888404
52regulation of sister chromatid cohesion (GO:0007063)3.21478387
53maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21035048
54termination of RNA polymerase II transcription (GO:0006369)3.20695093
55microtubule depolymerization (GO:0007019)3.20335460
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.20236050
57telomere maintenance via telomere lengthening (GO:0010833)3.19733582
58formation of translation preinitiation complex (GO:0001731)3.18920258
59regulation of spindle organization (GO:0090224)3.18172719
60mitotic nuclear envelope disassembly (GO:0007077)3.16081849
61regulation of translational fidelity (GO:0006450)3.15711739
62establishment of chromosome localization (GO:0051303)3.15063237
63maturation of SSU-rRNA (GO:0030490)3.14404653
64folic acid-containing compound biosynthetic process (GO:0009396)3.13706756
65protein localization to chromosome, centromeric region (GO:0071459)3.13235309
66negative regulation of histone methylation (GO:0031061)3.12235113
67DNA topological change (GO:0006265)3.11796303
68establishment of integrated proviral latency (GO:0075713)3.11778006
69DNA ligation (GO:0006266)3.11170329
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10900589
71mRNA splice site selection (GO:0006376)3.09861826
72regulation of centrosome duplication (GO:0010824)3.09398663
73negative regulation of DNA repair (GO:0045738)3.07510453
74nucleobase biosynthetic process (GO:0046112)3.06940695
75protein K6-linked ubiquitination (GO:0085020)3.06612907
76DNA conformation change (GO:0071103)3.06285064
77mismatch repair (GO:0006298)3.04267006
78regulation of mitotic spindle checkpoint (GO:1903504)3.04062241
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04062241
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03903578
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03469625
82positive regulation of chromosome segregation (GO:0051984)3.03073295
83spindle checkpoint (GO:0031577)3.01784471
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99571210
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.99571210
86DNA synthesis involved in DNA repair (GO:0000731)2.99477029
87telomere maintenance via telomerase (GO:0007004)2.98473927
88purine nucleobase biosynthetic process (GO:0009113)2.96574658
89negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96310726
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95640193
91ATP-dependent chromatin remodeling (GO:0043044)2.95632401
92spliceosomal complex assembly (GO:0000245)2.94288248
93regulation of mitotic sister chromatid separation (GO:0010965)2.94101332
94regulation of mitotic sister chromatid segregation (GO:0033047)2.94101332
95regulation of sister chromatid segregation (GO:0033045)2.94101332
96postreplication repair (GO:0006301)2.93533561
97regulation of chromosome segregation (GO:0051983)2.92798168
98membrane disassembly (GO:0030397)2.92468895
99nuclear envelope disassembly (GO:0051081)2.92468895
100negative regulation of sister chromatid segregation (GO:0033046)2.92395426
101negative regulation of mitotic sister chromatid separation (GO:2000816)2.92395426
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92395426
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92395426
104spindle assembly checkpoint (GO:0071173)2.91829284
105chromatin assembly or disassembly (GO:0006333)2.91012002
106positive regulation of histone H3-K4 methylation (GO:0051571)2.90543619
107chromosome segregation (GO:0007059)2.90328177
108sister chromatid cohesion (GO:0007062)2.88902769
109negative regulation of chromosome segregation (GO:0051985)2.88371150
110negative regulation of DNA recombination (GO:0045910)2.88166476
111pre-miRNA processing (GO:0031054)2.87835847
112IMP biosynthetic process (GO:0006188)2.87076387
113positive regulation of mitotic sister chromatid separation (GO:1901970)2.84589349
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84589349
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84589349
116RNA splicing, via transesterification reactions (GO:0000375)2.83617173
117mitotic spindle assembly checkpoint (GO:0007094)2.82612870
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82588931
119negative regulation of RNA splicing (GO:0033119)2.82476567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.63832031
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.26882460
3KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.05236152
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.03264582
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99975708
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99369885
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94622937
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.87973485
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62024709
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58616563
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34939417
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.26706084
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24467156
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.22148427
15YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20685503
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20423812
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.16761697
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10966283
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07053706
20ELK1_19687146_ChIP-ChIP_HELA_Human2.00769609
21E2F7_22180533_ChIP-Seq_HELA_Human10.4310428
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99038578
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92465856
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88969320
25FUS_26573619_Chip-Seq_HEK293_Human1.84728939
26AR_21909140_ChIP-Seq_LNCAP_Human1.84401291
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.80123939
28VDR_23849224_ChIP-Seq_CD4+_Human1.76801048
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73370339
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72015240
31EWS_26573619_Chip-Seq_HEK293_Human1.69815557
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66566018
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65390886
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64036074
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.63911059
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61509485
37FOXP3_21729870_ChIP-Seq_TREG_Human1.61278837
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59197150
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58156269
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.56177738
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55874517
42TTF2_22483619_ChIP-Seq_HELA_Human1.53125726
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52853481
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52658394
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49328662
46XRN2_22483619_ChIP-Seq_HELA_Human1.48868578
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43115021
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38122976
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37383528
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37239589
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36677166
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.34716254
53CIITA_25753668_ChIP-Seq_RAJI_Human1.34612998
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32348655
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31081878
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25165688
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24897332
58TAF15_26573619_Chip-Seq_HEK293_Human1.22781869
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19891415
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19890562
61DCP1A_22483619_ChIP-Seq_HELA_Human1.18890152
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17922574
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16732042
64MYC_18940864_ChIP-ChIP_HL60_Human1.14813293
65GBX2_23144817_ChIP-Seq_PC3_Human1.08935366
66IRF1_19129219_ChIP-ChIP_H3396_Human1.02099216
67KDM5A_27292631_Chip-Seq_BREAST_Human1.00583912
68GABP_19822575_ChIP-Seq_HepG2_Human0.99340509
69NOTCH1_21737748_ChIP-Seq_TLL_Human0.96682922
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95686046
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95541923
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94509989
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94037477
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94037477
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94037477
76NANOG_16153702_ChIP-ChIP_HESCs_Human0.93711622
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93096580
78IGF1R_20145208_ChIP-Seq_DFB_Human0.91155808
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89493458
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.88863565
81SRF_21415370_ChIP-Seq_HL-1_Mouse0.88473725
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88283863
83ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88067107
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87993264
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.87573158
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.86894825
87CHD1_26751641_Chip-Seq_LNCaP_Human0.86656819
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86478323
89GATA1_22025678_ChIP-Seq_K562_Human0.85828987
90SOX9_26525672_Chip-Seq_HEART_Mouse0.83495681
91TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82071734
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81913672
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81632200
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81629070
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80899235
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80778232
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80614491
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79704837
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79289096
100ZNF274_21170338_ChIP-Seq_K562_Hela0.78916925
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77464666
102VDR_22108803_ChIP-Seq_LS180_Human0.76168393
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76037812
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76016496
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75052012
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72560925
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72444697
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72351024
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71777910
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70146518
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.68872968
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68711168
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.68623470
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67609799
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.66398827
116TFEB_21752829_ChIP-Seq_HELA_Human0.65173708
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.64951248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.42019426
2MP0010094_abnormal_chromosome_stability4.25351957
3MP0003111_abnormal_nucleus_morphology3.40755142
4MP0003787_abnormal_imprinting3.36744560
5MP0003077_abnormal_cell_cycle3.27171233
6MP0008877_abnormal_DNA_methylation3.24089705
7MP0003121_genomic_imprinting3.23557634
8MP0003693_abnormal_embryo_hatching3.19225795
9MP0008058_abnormal_DNA_repair3.03830225
10MP0004957_abnormal_blastocyst_morpholog3.01350594
11MP0003123_paternal_imprinting2.71981547
12MP0006292_abnormal_olfactory_placode2.25155982
13MP0008932_abnormal_embryonic_tissue2.22864963
14MP0000569_abnormal_digit_pigmentation2.17742312
15MP0003890_abnormal_embryonic-extraembry2.14096626
16MP0008007_abnormal_cellular_replicative2.13817190
17MP0003136_yellow_coat_color1.81734171
18MP0000566_synostosis1.79835283
19MP0000350_abnormal_cell_proliferation1.79158925
20MP0003122_maternal_imprinting1.69366089
21MP0010307_abnormal_tumor_latency1.65145750
22MP0002396_abnormal_hematopoietic_system1.56657146
23MP0001730_embryonic_growth_arrest1.55614478
24MP0001188_hyperpigmentation1.54429683
25MP0002697_abnormal_eye_size1.45608728
26MP0003786_premature_aging1.41312557
27MP0002938_white_spotting1.32125616
28MP0002084_abnormal_developmental_patter1.31840085
29MP0006072_abnormal_retinal_apoptosis1.30884851
30MP0004133_heterotaxia1.30541788
31MP0005380_embryogenesis_phenotype1.29376732
32MP0001672_abnormal_embryogenesis/_devel1.29376732
33MP0002085_abnormal_embryonic_tissue1.27175622
34MP0003937_abnormal_limbs/digits/tail_de1.26478960
35MP0004197_abnormal_fetal_growth/weight/1.25650804
36MP0001697_abnormal_embryo_size1.23699551
37MP0003941_abnormal_skin_development1.22608689
38MP0003880_abnormal_central_pattern1.19323416
39MP0008995_early_reproductive_senescence1.18849350
40MP0002751_abnormal_autonomic_nervous1.15570404
41MP0001293_anophthalmia1.14526792
42MP0002102_abnormal_ear_morphology1.13873483
43MP0002095_abnormal_skin_pigmentation1.12835291
44MP0000015_abnormal_ear_pigmentation1.12525288
45MP0000778_abnormal_nervous_system1.11668449
46MP0003567_abnormal_fetal_cardiomyocyte1.07224687
47MP0004147_increased_porphyrin_level1.05571143
48MP0006035_abnormal_mitochondrial_morpho1.05205582
49MP0003315_abnormal_perineum_morphology1.04773091
50MP0002080_prenatal_lethality1.04578738
51MP0003984_embryonic_growth_retardation1.04431174
52MP0002088_abnormal_embryonic_growth/wei1.04237711
53MP0009697_abnormal_copulation1.03689636
54MP0003861_abnormal_nervous_system1.03209118
55MP0002210_abnormal_sex_determination1.02600009
56MP0009379_abnormal_foot_pigmentation1.01990504
57MP0001286_abnormal_eye_development1.00737733
58MP0005171_absent_coat_pigmentation1.00623941
59MP0002086_abnormal_extraembryonic_tissu1.00022130
60MP0000631_abnormal_neuroendocrine_gland0.99857854
61MP0009703_decreased_birth_body0.99370123
62MP0002111_abnormal_tail_morphology0.96713537
63MP0001529_abnormal_vocalization0.94934793
64MP0002653_abnormal_ependyma_morphology0.94168173
65MP0004808_abnormal_hematopoietic_stem0.92667042
66MP0004185_abnormal_adipocyte_glucose0.91358776
67MP0002092_abnormal_eye_morphology0.90841575
68MP0005174_abnormal_tail_pigmentation0.90742003
69MP0002233_abnormal_nose_morphology0.90735972
70MP0003755_abnormal_palate_morphology0.90409192
71MP0000313_abnormal_cell_death0.89758533
72MP0000490_abnormal_crypts_of0.87235669
73MP0005367_renal/urinary_system_phenotyp0.85723829
74MP0000516_abnormal_urinary_system0.85723829
75MP0005187_abnormal_penis_morphology0.84303544
76MP0005253_abnormal_eye_physiology0.83454150
77MP0003943_abnormal_hepatobiliary_system0.83245364
78MP0010030_abnormal_orbit_morphology0.82431926
79MP0001145_abnormal_male_reproductive0.81960723
80MP0000703_abnormal_thymus_morphology0.80562036
81MP0003718_maternal_effect0.80003515
82MP0003119_abnormal_digestive_system0.79352715
83MP0000537_abnormal_urethra_morphology0.78502627
84MP0003938_abnormal_ear_development0.78449406
85MP0002877_abnormal_melanocyte_morpholog0.78231374
86MP0010352_gastrointestinal_tract_polyps0.77400748
87MP0000358_abnormal_cell_content/0.77308272
88MP0005076_abnormal_cell_differentiation0.77061748
89MP0003221_abnormal_cardiomyocyte_apopto0.76305974
90MP0002009_preneoplasia0.75659220
91MP0009672_abnormal_birth_weight0.75391229
92MP0001929_abnormal_gametogenesis0.74827904
93MP0001346_abnormal_lacrimal_gland0.74667935
94MP0000432_abnormal_head_morphology0.73284753
95MP0000653_abnormal_sex_gland0.71621683
96MP0000647_abnormal_sebaceous_gland0.71518518
97MP0000428_abnormal_craniofacial_morphol0.71420658
98MP0003935_abnormal_craniofacial_develop0.70822138
99MP0005409_darkened_coat_color0.70571692
100MP0001485_abnormal_pinna_reflex0.70526347
101MP0000579_abnormal_nail_morphology0.70004790
102MP0002081_perinatal_lethality0.69702006
103MP0002163_abnormal_gland_morphology0.68877532
104MP0001177_atelectasis0.68731593
105MP0001119_abnormal_female_reproductive0.68698106
106MP0000049_abnormal_middle_ear0.68143382
107MP0003698_abnormal_male_reproductive0.67936987
108MP0005391_vision/eye_phenotype0.67347022
109MP0003385_abnormal_body_wall0.67037114
110MP0002177_abnormal_outer_ear0.66881137
111MP0008789_abnormal_olfactory_epithelium0.65929655
112MP0005551_abnormal_eye_electrophysiolog0.65870261
113MP0002114_abnormal_axial_skeleton0.65737582
114MP0001299_abnormal_eye_distance/0.65639191
115MP0001186_pigmentation_phenotype0.65593118
116MP0002019_abnormal_tumor_incidence0.65286074
117MP0005499_abnormal_olfactory_system0.65094633
118MP0005394_taste/olfaction_phenotype0.65094633
119MP0002152_abnormal_brain_morphology0.64823181
120MP0002075_abnormal_coat/hair_pigmentati0.64476701
121MP0002160_abnormal_reproductive_system0.64251457
122MP0003115_abnormal_respiratory_system0.62136792
123MP0005408_hypopigmentation0.61766320
124MP0002234_abnormal_pharynx_morphology0.61095396
125MP0003699_abnormal_female_reproductive0.59930718
126MP0000383_abnormal_hair_follicle0.59852288
127MP0005384_cellular_phenotype0.56700688
128MP0010678_abnormal_skin_adnexa0.55549137

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.65068847
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46724580
3Volvulus (HP:0002580)4.15742078
4Abnormality of the labia minora (HP:0012880)4.01564499
5Birth length less than 3rd percentile (HP:0003561)3.77918104
6Abnormality of chromosome stability (HP:0003220)3.38149080
7Medulloblastoma (HP:0002885)3.36010950
8Duplicated collecting system (HP:0000081)2.99039804
9Agnosia (HP:0010524)2.98835135
10Abnormality of the preputium (HP:0100587)2.86672200
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.80460885
12Supernumerary spleens (HP:0009799)2.78596346
13Meckel diverticulum (HP:0002245)2.78143892
14Abnormality of the renal collecting system (HP:0004742)2.76487392
15Absent radius (HP:0003974)2.76101853
16Ectopic kidney (HP:0000086)2.72631075
17Abnormality of the ileum (HP:0001549)2.70010521
18Impulsivity (HP:0100710)2.69574249
19Colon cancer (HP:0003003)2.64801919
20Ependymoma (HP:0002888)2.64036660
21Aplasia involving forearm bones (HP:0009822)2.62218071
22Absent forearm bone (HP:0003953)2.62218071
23Abnormal number of incisors (HP:0011064)2.60411413
24Patellar aplasia (HP:0006443)2.57948997
25Nephroblastoma (Wilms tumor) (HP:0002667)2.56122212
26Acute myeloid leukemia (HP:0004808)2.50463646
27Reticulocytopenia (HP:0001896)2.49157770
28Myelodysplasia (HP:0002863)2.48848055
29Embryonal renal neoplasm (HP:0011794)2.46006718
30Abnormality of DNA repair (HP:0003254)2.42781623
31Abnormality of cells of the erythroid lineage (HP:0012130)2.41008391
32Duodenal stenosis (HP:0100867)2.40847886
33Small intestinal stenosis (HP:0012848)2.40847886
34Macrocytic anemia (HP:0001972)2.40006128
35Aplasia/Hypoplasia of the patella (HP:0006498)2.36995143
36Cortical dysplasia (HP:0002539)2.33645176
37Neoplasm of the oral cavity (HP:0100649)2.30841658
38Abnormality of the astrocytes (HP:0100707)2.24639503
39Astrocytoma (HP:0009592)2.24639503
40Rhabdomyosarcoma (HP:0002859)2.24132372
41Overlapping toe (HP:0001845)2.22374627
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.19965227
43Intestinal atresia (HP:0011100)2.18799985
44Breast hypoplasia (HP:0003187)2.18722909
45Glioma (HP:0009733)2.17032360
46Abnormality of the duodenum (HP:0002246)2.10745717
47Abnormal lung lobation (HP:0002101)2.10446043
48Sloping forehead (HP:0000340)2.09584736
49Missing ribs (HP:0000921)2.08620388
50Abnormality of methionine metabolism (HP:0010901)2.06906907
51Horseshoe kidney (HP:0000085)2.05734838
52Embryonal neoplasm (HP:0002898)2.04657601
53Abnormal number of erythroid precursors (HP:0012131)2.03741519
54Increased nuchal translucency (HP:0010880)2.03190666
55Proximal placement of thumb (HP:0009623)2.02604249
56Protruding tongue (HP:0010808)2.02367899
57Pallor (HP:0000980)2.00807208
58Supernumerary bones of the axial skeleton (HP:0009144)1.97701646
59Abnormal hair whorl (HP:0010721)1.97682225
60Microvesicular hepatic steatosis (HP:0001414)1.97356108
61Anal stenosis (HP:0002025)1.95598050
62Abnormality of homocysteine metabolism (HP:0010919)1.95406836
63Homocystinuria (HP:0002156)1.95406836
64Oligodactyly (hands) (HP:0001180)1.94762156
65Premature graying of hair (HP:0002216)1.93566774
66Abnormality of the incisor (HP:0000676)1.91278718
67Neoplasm of the small intestine (HP:0100833)1.90744337
68Increased hepatocellular lipid droplets (HP:0006565)1.90235293
69Deviation of the thumb (HP:0009603)1.89375629
70Supernumerary ribs (HP:0005815)1.89100327
71Abnormality of the carotid arteries (HP:0005344)1.88858224
72Absent thumb (HP:0009777)1.87097685
73Facial hemangioma (HP:0000329)1.87027196
74Abnormality of cochlea (HP:0000375)1.86703083
75Triphalangeal thumb (HP:0001199)1.86533304
76Choanal atresia (HP:0000453)1.85384574
77Bone marrow hypocellularity (HP:0005528)1.84912197
78Clubbing of toes (HP:0100760)1.84475369
79Hepatoblastoma (HP:0002884)1.84199868
80Septo-optic dysplasia (HP:0100842)1.82542416
81Megaloblastic anemia (HP:0001889)1.80944520
82Multiple enchondromatosis (HP:0005701)1.79978218
8311 pairs of ribs (HP:0000878)1.79802014
84Abdominal situs inversus (HP:0003363)1.78616366
85Abnormality of abdominal situs (HP:0011620)1.78616366
86Diastasis recti (HP:0001540)1.77074637
87Oral leukoplakia (HP:0002745)1.76754129
88Pancreatic islet-cell hyperplasia (HP:0004510)1.76649939
89Abnormality of the pons (HP:0007361)1.74089636
90Selective tooth agenesis (HP:0001592)1.73019225
91Short thumb (HP:0009778)1.72444706
92Biliary tract neoplasm (HP:0100574)1.72193709
93Gonadotropin excess (HP:0000837)1.71809714
94Aplastic anemia (HP:0001915)1.71800388
95Aplasia/Hypoplasia of the earlobes (HP:0009906)1.71483694
96Facial cleft (HP:0002006)1.69818236
97Hypoplasia of the pons (HP:0012110)1.69323524
98Cafe-au-lait spot (HP:0000957)1.67434923
99Neoplasm of striated muscle (HP:0009728)1.67324594
100Preaxial hand polydactyly (HP:0001177)1.65686696
101Acute lymphatic leukemia (HP:0006721)1.64802189
102Abnormality of chromosome segregation (HP:0002916)1.64348310
103Asplenia (HP:0001746)1.64335767
104Hypoplastic labia majora (HP:0000059)1.64050908
105Sandal gap (HP:0001852)1.63630961
106Duplication of thumb phalanx (HP:0009942)1.63406340
107Gastrointestinal atresia (HP:0002589)1.62213042
108Cellular immunodeficiency (HP:0005374)1.61621956
109Lipid accumulation in hepatocytes (HP:0006561)1.61198576
110Arteriovenous malformation (HP:0100026)1.60847539
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60708821
112Ovarian neoplasm (HP:0100615)1.59976309
113Short middle phalanx of the 5th finger (HP:0004220)1.59527749
114Amaurosis fugax (HP:0100576)1.59388297
115Abnormality of the septum pellucidum (HP:0007375)1.59285833
116Oligodactyly (HP:0012165)1.59093239
117Tracheoesophageal fistula (HP:0002575)1.58863909
118Anophthalmia (HP:0000528)1.57766088
119Deep philtrum (HP:0002002)1.56280578
120Gastroesophageal reflux (HP:0002020)1.56172536
121Progressive muscle weakness (HP:0003323)1.55391025
122Atresia of the external auditory canal (HP:0000413)1.55268704
123Prominent nose (HP:0000448)1.54638234
124Microtia (HP:0008551)1.54226075
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.53251632
126Short 4th metacarpal (HP:0010044)1.53251632
127Long eyelashes (HP:0000527)1.53194626
128Neoplasm of the pancreas (HP:0002894)1.53082822
129Papillary thyroid carcinoma (HP:0002895)1.52844288
130Progressive external ophthalmoplegia (HP:0000590)1.51365369
131Neoplasm of the colon (HP:0100273)1.50456398
132Abnormality of the nasal septum (HP:0000419)1.49844023
133Esophageal atresia (HP:0002032)1.49460228
134Obsessive-compulsive behavior (HP:0000722)1.48745075
135Abnormality of the labia majora (HP:0012881)1.46762159
136Bifid tongue (HP:0010297)1.46068788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.81127841
2SRPK13.48365824
3MKNK22.88726090
4MKNK12.82540125
5WEE12.77573370
6BRD42.63998881
7PNCK2.61688382
8ACVR1B2.56945483
9CASK2.54287085
10TSSK62.48741571
11BUB12.24847815
12PLK32.10120833
13TTK2.06898373
14EIF2AK11.99265771
15CCNB11.96660039
16TLK11.90044750
17ATR1.89340519
18PASK1.74022506
19MST41.72388134
20TAF11.68124339
21NEK21.67236646
22PLK11.66134447
23AKT31.62543172
24VRK11.61778087
25CHEK21.59763339
26CDK121.59620051
27PLK41.55677197
28MAP3K101.44003453
29AURKB1.37680427
30CHEK11.34968327
31BCR1.30093498
32STK161.29565850
33VRK21.25909371
34ATM1.25803836
35ZAK1.25671808
36SIK31.24724160
37BRSK21.20594514
38YES11.14180404
39CDK71.12214252
40PBK1.12000905
41SCYL21.09547263
42LATS11.08252801
43BMPR1B1.07246314
44NEK11.04667832
45STK31.01452287
46NME11.01278132
47STK40.99563665
48EIF2AK30.98939976
49CLK10.97968263
50WNK30.97456090
51ERBB30.97227567
52CDK10.96411839
53CDK80.96379476
54CDK20.95195246
55RPS6KA40.93610645
56NUAK10.92953324
57EEF2K0.91923070
58PLK20.91213088
59CDK40.90869167
60EIF2AK20.89558466
61TRIM280.89015649
62STK38L0.85268164
63RPS6KB20.83352358
64DYRK30.82214769
65TGFBR10.79731909
66CDK60.79299590
67CAMK1G0.77764995
68MELK0.77239732
69CDK30.73997146
70CSNK2A20.71106953
71CSNK1E0.66829459
72AURKA0.65678131
73SIK20.65242816
74PRKDC0.65091552
75CSNK1G30.60597038
76CSNK1D0.59901871
77KSR10.59698767
78MAPK130.59635539
79RPS6KA50.59224151
80MAPK140.57535834
81FGFR20.56842267
82CSNK1A1L0.55386498
83DYRK1A0.55174810
84NEK60.50811153
85NTRK30.50654129
86CSNK2A10.50591422
87CDK90.49155725
88MAP3K40.48101096
89BRSK10.48078411
90NLK0.48036521
91FGFR10.47693902
92PRPF4B0.47295171
93DYRK20.47220765
94ERBB40.46912362
95GSK3B0.46509106
96ALK0.46429025
97NTRK20.46229000
98MAP2K70.44720917
99TNIK0.43987286
100CSNK1G20.43937972
101RPS6KB10.43246662
102CDK180.42648345
103MAP3K80.41614652
104MARK10.39996587
105CSNK1G10.39259594
106CDK190.39211087
107CAMK1D0.38846490
108TEC0.37511248
109STK390.36710940
110SGK20.35287361
111MAPK100.35036897
112PIM10.34979468
113STK240.34921189
114CDK150.33539479
115RAF10.31902756
116EPHA20.31899250
117CDK11A0.31127589
118AKT10.30361425
119UHMK10.29943462
120MAPKAPK50.29187608
121CDK140.29091882
122LATS20.28569250
123OXSR10.25710898
124PRKACB0.25696556

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.00706761
2DNA replication_Homo sapiens_hsa030303.91287211
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22748227
4* Spliceosome_Homo sapiens_hsa030403.20489982
5Homologous recombination_Homo sapiens_hsa034402.97990478
6Fanconi anemia pathway_Homo sapiens_hsa034602.90072715
7RNA transport_Homo sapiens_hsa030132.83939202
8RNA polymerase_Homo sapiens_hsa030202.76326612
9Non-homologous end-joining_Homo sapiens_hsa034502.70423271
10Cell cycle_Homo sapiens_hsa041102.66680415
11Nucleotide excision repair_Homo sapiens_hsa034202.62907376
12mRNA surveillance pathway_Homo sapiens_hsa030152.37152831
13Base excision repair_Homo sapiens_hsa034102.29494510
14RNA degradation_Homo sapiens_hsa030182.15175138
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13390508
16Basal transcription factors_Homo sapiens_hsa030222.08436531
17One carbon pool by folate_Homo sapiens_hsa006702.07930948
18Pyrimidine metabolism_Homo sapiens_hsa002401.82278865
19Systemic lupus erythematosus_Homo sapiens_hsa053221.75394210
20Ribosome_Homo sapiens_hsa030101.68173577
21Proteasome_Homo sapiens_hsa030501.66204119
22Selenocompound metabolism_Homo sapiens_hsa004501.51468131
23Nicotine addiction_Homo sapiens_hsa050331.40953454
24Oocyte meiosis_Homo sapiens_hsa041141.33065703
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28810033
26Alcoholism_Homo sapiens_hsa050341.27788494
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.26344486
28p53 signaling pathway_Homo sapiens_hsa041151.16694161
29Purine metabolism_Homo sapiens_hsa002301.14031110
30Epstein-Barr virus infection_Homo sapiens_hsa051691.12811752
31Phototransduction_Homo sapiens_hsa047441.09455434
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06611266
33Propanoate metabolism_Homo sapiens_hsa006401.05959510
34Viral carcinogenesis_Homo sapiens_hsa052031.05581039
35MicroRNAs in cancer_Homo sapiens_hsa052061.04211757
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00785969
37Parkinsons disease_Homo sapiens_hsa050120.93710584
38Pyruvate metabolism_Homo sapiens_hsa006200.86590503
39Herpes simplex infection_Homo sapiens_hsa051680.84585438
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83242100
41Oxidative phosphorylation_Homo sapiens_hsa001900.83041217
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81906678
43Steroid biosynthesis_Homo sapiens_hsa001000.81721494
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80182671
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79924571
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77685775
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75508973
48Colorectal cancer_Homo sapiens_hsa052100.73219390
49TGF-beta signaling pathway_Homo sapiens_hsa043500.69802936
50HTLV-I infection_Homo sapiens_hsa051660.68506964
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68017561
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67612929
53Biosynthesis of amino acids_Homo sapiens_hsa012300.62627015
54Wnt signaling pathway_Homo sapiens_hsa043100.62625591
55Basal cell carcinoma_Homo sapiens_hsa052170.59012358
56Hippo signaling pathway_Homo sapiens_hsa043900.57581681
57Taste transduction_Homo sapiens_hsa047420.56946205
58Long-term potentiation_Homo sapiens_hsa047200.56330977
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56021179
60Protein export_Homo sapiens_hsa030600.55635190
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52576196
62Antigen processing and presentation_Homo sapiens_hsa046120.52165345
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51996737
64Type I diabetes mellitus_Homo sapiens_hsa049400.51372556
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50465806
66Melanoma_Homo sapiens_hsa052180.50052695
67Prostate cancer_Homo sapiens_hsa052150.49966860
68Folate biosynthesis_Homo sapiens_hsa007900.47792363
69Axon guidance_Homo sapiens_hsa043600.46936888
70Long-term depression_Homo sapiens_hsa047300.45787825
71Morphine addiction_Homo sapiens_hsa050320.44836737
72Huntingtons disease_Homo sapiens_hsa050160.44698242
73Pathways in cancer_Homo sapiens_hsa052000.43559973
74Dopaminergic synapse_Homo sapiens_hsa047280.43000909
75Primary immunodeficiency_Homo sapiens_hsa053400.42874245
76Hedgehog signaling pathway_Homo sapiens_hsa043400.42130331
77Alzheimers disease_Homo sapiens_hsa050100.41943083
78Hepatitis B_Homo sapiens_hsa051610.41905797
79Serotonergic synapse_Homo sapiens_hsa047260.41752254
80Autoimmune thyroid disease_Homo sapiens_hsa053200.41002196
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39531132
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39278501
83Adherens junction_Homo sapiens_hsa045200.38550531
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38359429
85Carbon metabolism_Homo sapiens_hsa012000.37772451
86Vitamin B6 metabolism_Homo sapiens_hsa007500.37530291
87Circadian rhythm_Homo sapiens_hsa047100.36816232
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36229427
89Amphetamine addiction_Homo sapiens_hsa050310.35313315
90Lysine degradation_Homo sapiens_hsa003100.34648445
91Small cell lung cancer_Homo sapiens_hsa052220.34605180
92Glutamatergic synapse_Homo sapiens_hsa047240.34035109
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33425417
94Measles_Homo sapiens_hsa051620.32562974
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31567709
96Asthma_Homo sapiens_hsa053100.30797851
97Hematopoietic cell lineage_Homo sapiens_hsa046400.29077978
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28880088
99GABAergic synapse_Homo sapiens_hsa047270.28673857
100T cell receptor signaling pathway_Homo sapiens_hsa046600.28391740
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.27287175
102ErbB signaling pathway_Homo sapiens_hsa040120.26731391
103Circadian entrainment_Homo sapiens_hsa047130.26513520
104Non-small cell lung cancer_Homo sapiens_hsa052230.26383447
105FoxO signaling pathway_Homo sapiens_hsa040680.25957145
106Pancreatic cancer_Homo sapiens_hsa052120.25804348
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25571436
108Allograft rejection_Homo sapiens_hsa053300.25485292
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25276493
110Notch signaling pathway_Homo sapiens_hsa043300.24245808
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23698427
112Vibrio cholerae infection_Homo sapiens_hsa051100.22415221
113Metabolic pathways_Homo sapiens_hsa011000.22300382
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21959455
115Glioma_Homo sapiens_hsa052140.21936119
116MAPK signaling pathway_Homo sapiens_hsa040100.21655462
117Endometrial cancer_Homo sapiens_hsa052130.21232630
118Thyroid cancer_Homo sapiens_hsa052160.20935460
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20650373
120Viral myocarditis_Homo sapiens_hsa054160.20422698
121Collecting duct acid secretion_Homo sapiens_hsa049660.20124411
122Renal cell carcinoma_Homo sapiens_hsa052110.19816098
123Fatty acid biosynthesis_Homo sapiens_hsa000610.18742008
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18349531
125HIF-1 signaling pathway_Homo sapiens_hsa040660.18111337
126mTOR signaling pathway_Homo sapiens_hsa041500.17891219
127Shigellosis_Homo sapiens_hsa051310.17760575
128Tight junction_Homo sapiens_hsa045300.17596203
129Chronic myeloid leukemia_Homo sapiens_hsa052200.17561588
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16406885
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15815033
132Fatty acid metabolism_Homo sapiens_hsa012120.15169361
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.14552235
134Vitamin digestion and absorption_Homo sapiens_hsa049770.14388928
135Cardiac muscle contraction_Homo sapiens_hsa042600.14309876
136N-Glycan biosynthesis_Homo sapiens_hsa005100.13238565
137Nitrogen metabolism_Homo sapiens_hsa009100.11744661
138Olfactory transduction_Homo sapiens_hsa047400.10596843
139Glutathione metabolism_Homo sapiens_hsa004800.02364887

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