TXNDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.96690890
2axonemal dynein complex assembly (GO:0070286)9.81611592
3cilium or flagellum-dependent cell motility (GO:0001539)9.59226533
4spermatid development (GO:0007286)9.56091213
5response to pheromone (GO:0019236)9.17837636
6motile cilium assembly (GO:0044458)9.01034307
7regulation of cilium movement (GO:0003352)8.45390682
8cilium movement (GO:0003341)8.18705190
9single fertilization (GO:0007338)7.84860596
10piRNA metabolic process (GO:0034587)7.64526069
11male meiosis (GO:0007140)7.52831173
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45433201
13rRNA methylation (GO:0031167)7.34546034
14protein targeting to Golgi (GO:0000042)7.24409093
15sperm capacitation (GO:0048240)7.10671404
16synaptonemal complex organization (GO:0070193)7.10012078
17establishment of protein localization to Golgi (GO:0072600)6.94886460
18synaptonemal complex assembly (GO:0007130)6.94865120
19negative regulation of inclusion body assembly (GO:0090084)6.75899213
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.75236743
21fertilization (GO:0009566)6.66368036
22microtubule depolymerization (GO:0007019)6.57531586
23* spermatogenesis (GO:0007283)6.45595823
24* male gamete generation (GO:0048232)6.43349724
25rRNA modification (GO:0000154)6.20228810
26phosphatidylethanolamine biosynthetic process (GO:0006646)6.19490306
27* gamete generation (GO:0007276)6.01508323
28organic cation transport (GO:0015695)5.86235654
29phosphatidylethanolamine metabolic process (GO:0046337)5.72065367
30regulation of inclusion body assembly (GO:0090083)5.59563753
31germ cell development (GO:0007281)5.44141148
32cellular ketone body metabolic process (GO:0046950)5.38715679
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.35921388
34spermatid nucleus differentiation (GO:0007289)5.34826759
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.33485091
36calcium ion-dependent exocytosis (GO:0017156)5.27288462
37protein localization to Golgi apparatus (GO:0034067)5.20951687
38regulation of Rab GTPase activity (GO:0032313)5.11015061
39positive regulation of Rab GTPase activity (GO:0032851)5.11015061
40male meiosis I (GO:0007141)5.09278877
41ventricular system development (GO:0021591)5.03991065
42DNA methylation involved in gamete generation (GO:0043046)4.97249972
43microtubule severing (GO:0051013)4.94382388
44regulation of microtubule-based movement (GO:0060632)4.91048593
45chromatin silencing (GO:0006342)4.85366947
46chromosome condensation (GO:0030261)4.84781627
47cell recognition (GO:0008037)4.81705909
48chromosome organization involved in meiosis (GO:0070192)4.76037214
49* multicellular organismal reproductive process (GO:0048609)4.75095576
50ketone body metabolic process (GO:1902224)4.74867438
51single strand break repair (GO:0000012)4.59893993
52sexual reproduction (GO:0019953)4.54400314
53meiotic nuclear division (GO:0007126)4.51854399
54DNA packaging (GO:0006323)4.51645728
55monoubiquitinated protein deubiquitination (GO:0035520)4.32798875
56regulation of transcription involved in cell fate commitment (GO:0060850)4.32080397
57seminiferous tubule development (GO:0072520)4.25769733
58meiosis I (GO:0007127)4.13561421
59glomerular visceral epithelial cell development (GO:0072015)4.09018691
60left/right pattern formation (GO:0060972)4.01921126
61meiotic cell cycle (GO:0051321)3.96411980
62glomerular epithelial cell development (GO:0072310)3.89621578
63coenzyme catabolic process (GO:0009109)3.88804173
64multicellular organismal movement (GO:0050879)3.84706577
65musculoskeletal movement (GO:0050881)3.84706577
66negative regulation of Rho protein signal transduction (GO:0035024)3.82083212
67* multicellular organismal development (GO:0007275)3.68920732
68genitalia morphogenesis (GO:0035112)3.68336925
69protein polyglutamylation (GO:0018095)3.64699661
70microtubule polymerization or depolymerization (GO:0031109)3.61557000
71microtubule nucleation (GO:0007020)3.51764904
72chaperone-mediated protein complex assembly (GO:0051131)3.49047818
73protein K11-linked deubiquitination (GO:0035871)3.48612209
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39132131
75protein-DNA complex disassembly (GO:0032986)3.36179205
76nucleosome disassembly (GO:0006337)3.36179205
77mitotic sister chromatid cohesion (GO:0007064)3.33270806
78regulation of spindle checkpoint (GO:0090231)3.33239178
79negative regulation of gene expression, epigenetic (GO:0045814)3.32324267
80nucleus organization (GO:0006997)3.31711107
81protein refolding (GO:0042026)3.26450455
82protein depolymerization (GO:0051261)3.24942747
83histone H3-K9 demethylation (GO:0033169)3.22328538
84membrane protein intracellular domain proteolysis (GO:0031293)3.21364990
85glycolytic process (GO:0006096)3.21092872
86regulation of interleukin-13 production (GO:0032656)3.20252219
87response to acidic pH (GO:0010447)3.16959614
88regulation of meiosis I (GO:0060631)3.13118519
89cerebral cortex neuron differentiation (GO:0021895)3.12614109
90DNA conformation change (GO:0071103)3.11737064
91meiotic cell cycle process (GO:1903046)3.10898604
92regulation of T-helper 2 cell differentiation (GO:0045628)3.10770393
93peptidyl-threonine dephosphorylation (GO:0035970)3.09508565
94cellular response to pH (GO:0071467)3.08142214
95homeostasis of number of cells within a tissue (GO:0048873)3.07520282
96mesenchymal cell differentiation involved in renal system development (GO:2001012)3.04721296
97mesenchymal cell differentiation involved in kidney development (GO:0072161)3.04721296
98centriole assembly (GO:0098534)2.94743463
99cell differentiation involved in metanephros development (GO:0072202)2.92985665
100carnitine transport (GO:0015879)2.90622297
101amino-acid betaine transport (GO:0015838)2.90622297
102cilium organization (GO:0044782)2.89218971
103cranial nerve morphogenesis (GO:0021602)2.88558764
104polyol catabolic process (GO:0046174)2.88114100
105gene silencing by RNA (GO:0031047)2.87088777
106nucleoside diphosphate phosphorylation (GO:0006165)2.83591709
107regulation of somitogenesis (GO:0014807)2.81380915
108microtubule-based movement (GO:0007018)2.79506844
109receptor recycling (GO:0001881)2.79469555
110protein localization to cilium (GO:0061512)2.79300325
111cilium assembly (GO:0042384)2.78410285
112mitotic G1 DNA damage checkpoint (GO:0031571)2.76016085
113alditol metabolic process (GO:0019400)2.74785403
114centriole replication (GO:0007099)2.74476348
115NAD biosynthetic process (GO:0009435)2.73657462
116negative regulation of histone methylation (GO:0031061)2.73510492
117sequestering of actin monomers (GO:0042989)2.71730687
118carnitine transmembrane transport (GO:1902603)2.71632996
119lactate metabolic process (GO:0006089)2.70871161
120detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.70415459
121regulation of cilium assembly (GO:1902017)2.69421207
122regulation of phosphoprotein phosphatase activity (GO:0043666)2.69317412
123negative regulation of organelle assembly (GO:1902116)2.66187272
124synapsis (GO:0007129)2.65191287
125cellular component assembly involved in morphogenesis (GO:0010927)2.64684894
126polyamine biosynthetic process (GO:0006596)2.62366018
127histone exchange (GO:0043486)2.62328409
128regulation of centriole replication (GO:0046599)2.62253607
129protein localization to chromosome, centromeric region (GO:0071459)2.60967668
130RNA localization (GO:0006403)2.60461585
131nuclear pore complex assembly (GO:0051292)2.59797294
132intraciliary transport (GO:0042073)2.58631260
133gene silencing (GO:0016458)2.56921559
134RNA destabilization (GO:0050779)2.56720221
135cilium morphogenesis (GO:0060271)2.55155605
136sister chromatid cohesion (GO:0007062)2.55018570
137GTP biosynthetic process (GO:0006183)2.54775593
138sperm motility (GO:0030317)13.8273007
139fusion of sperm to egg plasma membrane (GO:0007342)13.3574897
140cell wall macromolecule metabolic process (GO:0044036)12.3151354
141cell wall macromolecule catabolic process (GO:0016998)12.3151354
142multicellular organism reproduction (GO:0032504)11.5163105
143acrosome reaction (GO:0007340)11.3955574
144sperm-egg recognition (GO:0035036)11.2217457
145acrosome assembly (GO:0001675)10.5035771
146binding of sperm to zona pellucida (GO:0007339)10.2794661
147plasma membrane fusion (GO:0045026)10.1723435
148epithelial cilium movement (GO:0003351)10.1202276
149cell-cell recognition (GO:0009988)10.0327479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.81501161
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.72786617
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.57395061
4EZH2_22144423_ChIP-Seq_EOC_Human4.08162178
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.96143997
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.77333803
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10383721
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84663879
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69605412
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54839434
11VDR_22108803_ChIP-Seq_LS180_Human2.41811240
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.28236291
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23932406
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.23875956
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13290677
16ELF1_20517297_ChIP-Seq_JURKAT_Human2.08776376
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06046779
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.04359922
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01143248
20ERA_21632823_ChIP-Seq_H3396_Human1.99632726
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.97651540
22RAC3_21632823_ChIP-Seq_H3396_Human1.95248241
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94359175
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.90658341
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.89012611
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.83523972
27DROSHA_22980978_ChIP-Seq_HELA_Human1.83122677
28STAT1_17558387_ChIP-Seq_HELA_Human1.82974276
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78978522
30NANOG_20526341_ChIP-Seq_ESCs_Human1.78661961
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.77458555
32* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.76587554
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75346740
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72300627
35CTCF_27219007_Chip-Seq_Bcells_Human1.71281239
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.69106410
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65501009
38ZNF274_21170338_ChIP-Seq_K562_Hela1.64510169
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63943198
40* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63286725
41MYC_19829295_ChIP-Seq_ESCs_Human1.63109136
42TAF2_19829295_ChIP-Seq_ESCs_Human1.62684292
43BCL6_27268052_Chip-Seq_Bcells_Human1.62276333
44ER_23166858_ChIP-Seq_MCF-7_Human1.62202720
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59994043
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.59756078
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58143750
48* KDM2B_26808549_Chip-Seq_REH_Human1.57804302
49E2F1_20622854_ChIP-Seq_HELA_Human1.56694836
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.56586134
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.55770180
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.55344179
53SMC4_20622854_ChIP-Seq_HELA_Human1.55340476
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53859791
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53153697
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.52762416
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51315061
58SOX2_22085726_ChIP-Seq_NPCs_Mouse1.51313221
59BCOR_27268052_Chip-Seq_Bcells_Human1.50662032
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49575971
61CTCF_20526341_ChIP-Seq_ESCs_Human1.49168902
62P68_20966046_ChIP-Seq_HELA_Human1.48489254
63PHF8_20622854_ChIP-Seq_HELA_Human1.47106195
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.47061880
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46810209
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.46672454
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.46480215
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44661666
69CBP_20019798_ChIP-Seq_JUKART_Human1.44661666
70OCT4_20526341_ChIP-Seq_ESCs_Human1.44024424
71TP53_18474530_ChIP-ChIP_U2OS_Human1.43849416
72RBPJ_21746931_ChIP-Seq_IB4_Human1.42871736
73* TP63_22573176_ChIP-Seq_HFKS_Human1.42364492
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41166069
75CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.40803632
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.39600048
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39541811
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.39372305
79AR_25329375_ChIP-Seq_VCAP_Human1.38271859
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35852918
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34365539
82LXR_22292898_ChIP-Seq_THP-1_Human1.33504018
83TAF15_26573619_Chip-Seq_HEK293_Human1.33219994
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32367028
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32367028
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.30558872
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30335788
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.30035219
89P300_27268052_Chip-Seq_Bcells_Human1.30034345
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29922500
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.29841065
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.28851879
93CEBPB_22108803_ChIP-Seq_LS180_Human1.27891724
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.27263947
95FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26137256
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25072249
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24512778
98GF1_26923725_Chip-Seq_HPCs_Mouse1.23250425
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22968912
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22874574
101LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22120446
102KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21865823
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21281389
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20843691
105P53_21459846_ChIP-Seq_SAOS-2_Human1.20496944
106RUNX_20019798_ChIP-Seq_JUKART_Human1.20174289
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19351548
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19086205
109PHF8_20622853_ChIP-Seq_HELA_Human1.19053496
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18644385
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17999748
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.17323968
113* GATA3_21878914_ChIP-Seq_MCF-7_Human1.17213798
114SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17032699
115REST_21632747_ChIP-Seq_MESCs_Mouse1.16967929
116GATA6_21074721_ChIP-Seq_CACO-2_Human1.15937189
117FUS_26573619_Chip-Seq_HEK293_Human1.15003115
118SA1_27219007_Chip-Seq_Bcells_Human1.14692942
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14512040
120* P300_19829295_ChIP-Seq_ESCs_Human1.14473331
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.13938461
122ERG_20517297_ChIP-Seq_VCAP_Human1.13373250
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.13089052
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12899772
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12882508
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12709522
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.11663090
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11616038
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11407270
130RNF2_27304074_Chip-Seq_NSC_Mouse1.10464129
131SPI1_26923725_Chip-Seq_HPCs_Mouse1.10390202
132P53_22387025_ChIP-Seq_ESCs_Mouse1.10083754
133SMRT_27268052_Chip-Seq_Bcells_Human1.10010790
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09795977
135PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09098320
136* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08674512
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06923606
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06668030
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06240892
140ESET_19884257_ChIP-Seq_ESCs_Mouse1.06085205
141NFYA_21822215_ChIP-Seq_K562_Human1.04910556
142RUNX2_22187159_ChIP-Seq_PCA_Human1.04905629
143EZH2_27294783_Chip-Seq_NPCs_Mouse1.04554887
144KLF4_18555785_Chip-Seq_ESCs_Mouse1.03446645
145HOXB7_26014856_ChIP-Seq_BT474_Human1.02867789
146P300_18555785_Chip-Seq_ESCs_Mouse1.02707243
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01919452
148SOX2_19829295_ChIP-Seq_ESCs_Human1.01599375
149NANOG_19829295_ChIP-Seq_ESCs_Human1.01599375
150NFYB_21822215_ChIP-Seq_K562_Human1.01462853
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01153687
152OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00796974
153RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00633196
154TBL1_22424771_ChIP-Seq_293T_Human1.00400643
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99205953
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99027813
157EZH2_27294783_Chip-Seq_ESCs_Mouse0.98849763
158GF1B_26923725_Chip-Seq_HPCs_Mouse0.97581074
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97145220
160OCT1_27270436_Chip-Seq_PROSTATE_Human0.96783687
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.95925524
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95839480
163PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95669379
164STAT3_18555785_Chip-Seq_ESCs_Mouse0.95125975
165SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95039511
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94527906
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94045424
168GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93907114
169SOX2_18555785_Chip-Seq_ESCs_Mouse0.93569001
170ETV1_20927104_ChIP-Seq_GIST48_Human0.93383599
171SOX9_26525672_Chip-Seq_HEART_Mouse0.92871321
172MYC_27129775_Chip-Seq_CORNEA_Mouse0.92270257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07163648
2MP0001929_abnormal_gametogenesis5.73685247
3MP0008877_abnormal_DNA_methylation4.59172554
4MP0001348_abnormal_lacrimal_gland3.85296201
5MP0002210_abnormal_sex_determination3.64604965
6MP0002161_abnormal_fertility/fecundity3.51078066
7MP0001145_abnormal_male_reproductive3.03328146
8MP0000653_abnormal_sex_gland2.80025547
9MP0002653_abnormal_ependyma_morphology2.79498423
10MP0005670_abnormal_white_adipose2.71378969
11MP0000678_abnormal_parathyroid_gland2.57953228
12MP0003646_muscle_fatigue2.09664344
13MP0002132_abnormal_respiratory_system2.07144271
14MP0005410_abnormal_fertilization15.6457170
15MP0005379_endocrine/exocrine_gland_phen1.94894694
16MP0005423_abnormal_somatic_nervous1.64787916
17MP0001485_abnormal_pinna_reflex1.60441484
18MP0002249_abnormal_larynx_morphology1.55486847
19MP0001486_abnormal_startle_reflex1.54134645
20MP0005310_abnormal_salivary_gland1.53965585
21MP0002160_abnormal_reproductive_system1.50932403
22MP0004510_myositis1.48568104
23MP0002282_abnormal_trachea_morphology1.44797566
24MP0009053_abnormal_anal_canal1.43328334
25MP0002102_abnormal_ear_morphology1.40401581
26MP0004742_abnormal_vestibular_system1.35592226
27MP0005623_abnormal_meninges_morphology1.29479686
28MP0004233_abnormal_muscle_weight1.20935266
29MP0005248_abnormal_Harderian_gland1.14995924
30MP0004859_abnormal_synaptic_plasticity1.14963137
31MP0002138_abnormal_hepatobiliary_system1.14004166
32MP0002735_abnormal_chemical_nociception1.10672413
33MP0001963_abnormal_hearing_physiology1.10585751
34MP0008058_abnormal_DNA_repair1.09344963
35MP0010094_abnormal_chromosome_stability1.08820334
36MP0002127_abnormal_cardiovascular_syste1.08304470
37MP0005647_abnormal_sex_gland1.07119942
38MP0008995_early_reproductive_senescence1.00510418
39MP0003699_abnormal_female_reproductive0.98151549
40MP0000026_abnormal_inner_ear0.96026853
41MP0005389_reproductive_system_phenotype0.89863647
42MP0000681_abnormal_thyroid_gland0.86118596
43MP0002229_neurodegeneration0.84819646
44MP0001119_abnormal_female_reproductive0.82579749
45MP0003111_abnormal_nucleus_morphology0.80008627
46MP0000955_abnormal_spinal_cord0.79997301
47MP0001984_abnormal_olfaction0.79514864
48MP0003718_maternal_effect0.79022100
49MP0002822_catalepsy0.77906916
50MP0005451_abnormal_body_composition0.76529262
51MP0005083_abnormal_biliary_tract0.73488112
52MP0000049_abnormal_middle_ear0.73279843
53* MP0001765_abnormal_ion_homeostasis0.72829216
54MP0002733_abnormal_thermal_nociception0.71557270
55MP0003115_abnormal_respiratory_system0.71552941
56MP0002067_abnormal_sensory_capabilities0.70340923
57MP0004085_abnormal_heartbeat0.70057639
58MP0000516_abnormal_urinary_system0.68652906
59MP0005367_renal/urinary_system_phenotyp0.68652906
60MP0005375_adipose_tissue_phenotype0.66658556
61MP0009697_abnormal_copulation0.66342410
62MP0008569_lethality_at_weaning0.65806418
63MP0005167_abnormal_blood-brain_barrier0.65487263
64MP0000569_abnormal_digit_pigmentation0.64529163
65MP0001879_abnormal_lymphatic_vessel0.64203154
66MP0005666_abnormal_adipose_tissue0.61981217
67MP0002557_abnormal_social/conspecific_i0.61020662
68MP0003950_abnormal_plasma_membrane0.60419971
69MP0005377_hearing/vestibular/ear_phenot0.57292327
70MP0003878_abnormal_ear_physiology0.57292327
71MP0009046_muscle_twitch0.57196527
72MP0002234_abnormal_pharynx_morphology0.55471996
73MP0003329_amyloid_beta_deposits0.55231210
74MP0001666_abnormal_nutrient_absorption0.54132236
75MP0002572_abnormal_emotion/affect_behav0.52527829
76MP0000003_abnormal_adipose_tissue0.52483518
77MP0004484_altered_response_of0.52116686
78MP0004036_abnormal_muscle_relaxation0.51864133
79MP0003077_abnormal_cell_cycle0.51581302
80MP0003787_abnormal_imprinting0.51531518
81MP0003011_delayed_dark_adaptation0.49900816
82MP0003137_abnormal_impulse_conducting0.48509177
83MP0000358_abnormal_cell_content/0.48353941
84MP0004145_abnormal_muscle_electrophysio0.47400382
85MP0005535_abnormal_body_temperature0.47085039
86MP0001905_abnormal_dopamine_level0.46836752
87MP0002269_muscular_atrophy0.46660192
88MP0005408_hypopigmentation0.46370119
89MP0001970_abnormal_pain_threshold0.45649595
90MP0002295_abnormal_pulmonary_circulatio0.44280988
91MP0008961_abnormal_basal_metabolism0.43446401
92MP0001324_abnormal_eye_pigmentation0.43052074
93MP0001730_embryonic_growth_arrest0.42664237
94MP0003693_abnormal_embryo_hatching0.42072439
95MP0008007_abnormal_cellular_replicative0.42039479
96MP0002272_abnormal_nervous_system0.41852257
97MP0001501_abnormal_sleep_pattern0.41630917
98MP0000249_abnormal_blood_vessel0.41205235
99MP0000534_abnormal_ureter_morphology0.39915993
100MP0002736_abnormal_nociception_after0.39852462
101MP0001440_abnormal_grooming_behavior0.39815672
102MP0002734_abnormal_mechanical_nocicepti0.39500490
103MP0000230_abnormal_systemic_arterial0.39422269
104MP0003119_abnormal_digestive_system0.39141326
105MP0001529_abnormal_vocalization0.38319989
106MP0005084_abnormal_gallbladder_morpholo0.37971217
107MP0005395_other_phenotype0.37488850
108MP0009745_abnormal_behavioral_response0.37431690
109MP0001764_abnormal_homeostasis0.37287987
110MP0002928_abnormal_bile_duct0.37263475
111MP0003786_premature_aging0.37027135
112MP0006292_abnormal_olfactory_placode0.36197062
113MP0000462_abnormal_digestive_system0.35950254
114MP0009115_abnormal_fat_cell0.35402678
115MP0002971_abnormal_brown_adipose0.35328373
116MP0003880_abnormal_central_pattern0.35243425
117MP0005253_abnormal_eye_physiology0.35033895
118MP0000470_abnormal_stomach_morphology0.34211931
119MP0001293_anophthalmia0.34027327
120MP0005551_abnormal_eye_electrophysiolog0.33973440
121MP0005397_hematopoietic_system_phenotyp0.33949484
122MP0001545_abnormal_hematopoietic_system0.33949484
123MP0004270_analgesia0.33475184
124MP0003861_abnormal_nervous_system0.33013755
125MP0005332_abnormal_amino_acid0.32597121
126MP0004084_abnormal_cardiac_muscle0.32209228
127MP0002084_abnormal_developmental_patter0.32138133
128MP0000613_abnormal_salivary_gland0.31737248
129MP0003172_abnormal_lysosome_physiology0.31403118
130MP0003942_abnormal_urinary_system0.31380911
131MP0003631_nervous_system_phenotype0.30404183
132MP0010329_abnormal_lipoprotein_level0.30245926
133MP0001849_ear_inflammation0.29264198
134MP0001697_abnormal_embryo_size0.29102492
135MP0005380_embryogenesis_phenotype0.26991195
136MP0001672_abnormal_embryogenesis/_devel0.26991195
137* MP0005636_abnormal_mineral_homeostasis0.26304420
138MP0004957_abnormal_blastocyst_morpholog0.25876032
139MP0002085_abnormal_embryonic_tissue0.25828321
140MP0005391_vision/eye_phenotype0.25719292
141MP0006072_abnormal_retinal_apoptosis0.25626605
142MP0003879_abnormal_hair_cell0.25545140
143MP0001919_abnormal_reproductive_system0.25411472
144MP0001727_abnormal_embryo_implantation0.25070939
145MP0010307_abnormal_tumor_latency0.24960530
146MP0009278_abnormal_bone_marrow0.24502750
147MP0009250_abnormal_appendicular_skeleto0.23943533
148MP0008057_abnormal_DNA_replication0.23778689
149MP0000313_abnormal_cell_death0.22910515
150MP0002169_no_abnormal_phenotype0.22437372
151MP0000604_amyloidosis0.22364525
152MP0002873_normal_phenotype0.22219173
153MP0002152_abnormal_brain_morphology0.22196458
154MP0006036_abnormal_mitochondrial_physio0.21416610
155MP0009672_abnormal_birth_weight0.19542352
156MP0005646_abnormal_pituitary_gland0.19413210
157MP0001851_eye_inflammation0.19217872
158MP0001968_abnormal_touch/_nociception0.16765305
159MP0000001_mammalian_phenotype0.15909848
160MP0002080_prenatal_lethality0.15670959
161MP0003984_embryonic_growth_retardation0.15277749
162MP0003936_abnormal_reproductive_system0.15149701
163MP0008932_abnormal_embryonic_tissue0.14514467
164MP0002109_abnormal_limb_morphology0.14193815

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.17124454
2Abnormal respiratory motile cilium morphology (HP:0005938)9.05768438
3Abnormal respiratory epithelium morphology (HP:0012253)9.05768438
4Severe visual impairment (HP:0001141)8.33335889
5Abnormal ciliary motility (HP:0012262)7.33095055
6Rhinitis (HP:0012384)7.21579674
7Chronic bronchitis (HP:0004469)7.21396346
8Infertility (HP:0000789)7.00261446
9Nasal polyposis (HP:0100582)5.97992583
10Male infertility (HP:0003251)5.87660271
11Attenuation of retinal blood vessels (HP:0007843)5.01337346
12Bony spicule pigmentary retinopathy (HP:0007737)4.98410556
13Abnormality of the nasal mucosa (HP:0000433)4.87979626
14Chronic hepatic failure (HP:0100626)4.86098903
15Resting tremor (HP:0002322)4.61360164
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.46611652
17Bronchitis (HP:0012387)4.43220551
18Bronchiectasis (HP:0002110)4.39264772
19Hyperkalemia (HP:0002153)4.27113648
20Nephronophthisis (HP:0000090)4.26446725
21Abnormality of macular pigmentation (HP:0008002)4.10769037
22Cone-rod dystrophy (HP:0000548)4.05165531
23Abnormal rod and cone electroretinograms (HP:0008323)3.86198328
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.81071015
25Abnormal spermatogenesis (HP:0008669)3.79265299
26Potter facies (HP:0002009)3.77090642
27Facial shape deformation (HP:0011334)3.77090642
28Hypoplastic ischia (HP:0003175)3.75543172
29Enlarged epiphyses (HP:0010580)3.63768209
30Abnormality of the ischium (HP:0003174)3.34141535
31Recurrent sinusitis (HP:0011108)3.30061878
32Hypoplasia of the thymus (HP:0000778)3.28510521
33Abnormality of the renal medulla (HP:0100957)3.25546447
34Progressive sensorineural hearing impairment (HP:0000408)3.23782567
35Recurrent otitis media (HP:0000403)3.22456720
36Hypoalphalipoproteinemia (HP:0003233)3.14774260
37Tubulointerstitial nephritis (HP:0001970)3.05585015
38Unilateral renal agenesis (HP:0000122)3.02307630
39Postural instability (HP:0002172)2.97816352
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.96065102
41Amelogenesis imperfecta (HP:0000705)2.90357622
42Abnormality of dental color (HP:0011073)2.79208785
43Impulsivity (HP:0100710)2.77014644
44Menstrual irregularities (HP:0000858)2.71578569
45Progressive cerebellar ataxia (HP:0002073)2.70506448
46Abnormality of the aortic arch (HP:0012303)2.68730736
47Abnormality of midbrain morphology (HP:0002418)2.68436304
48Molar tooth sign on MRI (HP:0002419)2.68436304
49Tubular atrophy (HP:0000092)2.60997357
50Renovascular hypertension (HP:0100817)2.59447457
51Generalized aminoaciduria (HP:0002909)2.58354293
52Recurrent bronchitis (HP:0002837)2.57770021
53Insulin-resistant diabetes mellitus (HP:0000831)2.53717945
54Portal hypertension (HP:0001409)2.53169728
55Abnormality of the costochondral junction (HP:0000919)2.49810843
56Abnormal gallbladder physiology (HP:0012438)2.47424500
57Cholecystitis (HP:0001082)2.47424500
58Abnormality of potassium homeostasis (HP:0011042)2.45967763
59Tubulointerstitial abnormality (HP:0001969)2.42757046
60Medial flaring of the eyebrow (HP:0010747)2.38465479
61Azoospermia (HP:0000027)2.36862907
62Ventricular tachycardia (HP:0004756)2.36578864
63Abnormality of the hepatic vasculature (HP:0006707)2.31244504
64Focal segmental glomerulosclerosis (HP:0000097)2.28418523
65Gonadotropin excess (HP:0000837)2.23452776
66Flattened epiphyses (HP:0003071)2.21670488
67Abnormality of the parathyroid morphology (HP:0011766)2.19444079
68Osteomalacia (HP:0002749)2.18045266
69Polyuria (HP:0000103)2.12781427
70Progressive hearing impairment (HP:0001730)2.10444753
71Increased purine levels (HP:0004368)2.03440094
72Hyperuricemia (HP:0002149)2.03440094
73Intellectual disability, moderate (HP:0002342)2.02926610
74Epiphyseal dysplasia (HP:0002656)2.02800397
75Hyponatremia (HP:0002902)2.01530776
76Dynein arm defect of respiratory motile cilia (HP:0012255)13.3976192
77Absent/shortened dynein arms (HP:0200106)13.3976192
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9726185
79Abnormality of the epiphysis of the femoral head (HP:0010574)1.99514483
80Dyschromatopsia (HP:0007641)1.97616295
81Heterotopia (HP:0002282)1.94687754
82Widely patent fontanelles and sutures (HP:0004492)1.94001232
83Hypophosphatemic rickets (HP:0004912)1.93831901
84Myokymia (HP:0002411)1.88807608
85Tetany (HP:0001281)1.88274522
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87990467
87Abnormality of the pubic bones (HP:0003172)1.86967560
88Abnormality of femoral epiphyses (HP:0006499)1.86676674
89Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86676674
90Recurrent pneumonia (HP:0006532)1.86208969
91Bradycardia (HP:0001662)1.86123594
92Spastic tetraparesis (HP:0001285)1.84656652
93Postaxial foot polydactyly (HP:0001830)1.83559522
94Recurrent corneal erosions (HP:0000495)1.81585349
95Glomerulosclerosis (HP:0000096)1.81412282
96Hyperthyroidism (HP:0000836)1.80952166
97Stage 5 chronic kidney disease (HP:0003774)1.80664030
98Tubulointerstitial fibrosis (HP:0005576)1.80115990
99Flat capital femoral epiphysis (HP:0003370)1.79316142
100Hypoparathyroidism (HP:0000829)1.79312587
101Abnormal ventriculo-arterial connection (HP:0011563)1.77508554
102Transposition of the great arteries (HP:0001669)1.77508554
103Abnormal connection of the cardiac segments (HP:0011545)1.77508554
104Decreased central vision (HP:0007663)1.76670910
105Asymmetric septal hypertrophy (HP:0001670)1.73400901
106Bile duct proliferation (HP:0001408)1.70877592
107Abnormal biliary tract physiology (HP:0012439)1.70877592
108Choroideremia (HP:0001139)1.69534518
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65185821
110Abnormality of the renal cortex (HP:0011035)1.64112106
111Short ribs (HP:0000773)1.62988672
112Polydipsia (HP:0001959)1.59724276
113Abnormal drinking behavior (HP:0030082)1.59724276
114Congenital hepatic fibrosis (HP:0002612)1.59001830
115Hemorrhage of the eye (HP:0011885)1.54053391
116Abnormality of the dental root (HP:0006486)1.53244718
117Taurodontia (HP:0000679)1.53244718
118Abnormality of permanent molar morphology (HP:0011071)1.53244718
119Bundle branch block (HP:0011710)1.52942992
120Oculomotor apraxia (HP:0000657)1.52826277
121Abnormality of renal excretion (HP:0011036)1.50272480
122Supernumerary spleens (HP:0009799)1.49933112
123Pancreatic fibrosis (HP:0100732)1.45687871
124Postaxial hand polydactyly (HP:0001162)1.45630943
125Bell-shaped thorax (HP:0001591)1.44896206
126Cystic liver disease (HP:0006706)1.44779224
127Abnormality of molar morphology (HP:0011070)1.41122121
128Abnormality of molar (HP:0011077)1.41122121
129Aplasia/Hypoplasia of the lens (HP:0008063)1.40662778
130Abnormality of the dental pulp (HP:0006479)1.39676657
131Microglossia (HP:0000171)1.39131847
132Papillary thyroid carcinoma (HP:0002895)1.38016144
133Abnormality of dentin (HP:0010299)1.37592121
134Renal dysplasia (HP:0000110)1.34667461
135Congenital primary aphakia (HP:0007707)1.31740751
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.31250801
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.31215121
138Absent epiphyses (HP:0010577)1.31215121
139Gait imbalance (HP:0002141)1.31037290
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.29485152
141Retrobulbar optic neuritis (HP:0100654)1.28355755
142Optic neuritis (HP:0100653)1.28355755
143Abnormality of the lower motor neuron (HP:0002366)1.27581411
144Neurofibrillary tangles (HP:0002185)1.27402281
145Fibular hypoplasia (HP:0003038)1.23969929
146Abnormality of the neuromuscular junction (HP:0003398)1.22043862
147Fatigable weakness (HP:0003473)1.22043862
148Truncal obesity (HP:0001956)1.22021965
149Short thorax (HP:0010306)1.21125049
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20618425
151Constricted visual fields (HP:0001133)1.20253123
152Abnormal urine output (HP:0012590)1.19765911
153True hermaphroditism (HP:0010459)1.19343684
154Absent frontal sinuses (HP:0002688)1.18211060
155Amyotrophic lateral sclerosis (HP:0007354)1.18012532
156Easy fatigability (HP:0003388)1.17746278
157Facial cleft (HP:0002006)1.17679068
158Hemiparesis (HP:0001269)1.17589999
159Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.17392259
160Congenital malformation of the right heart (HP:0011723)1.16905681
161Double outlet right ventricle (HP:0001719)1.16905681
162Deformed sella turcica (HP:0002681)1.14992702
163Sensory axonal neuropathy (HP:0003390)1.12772945
164Chronic sinusitis (HP:0011109)1.12644916
165Short femoral neck (HP:0100864)1.10749115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.53810146
2PDK48.53810146
3PDK25.50917085
4TESK15.04946789
5PRKD34.99351137
6DDR24.55337740
7INSRR4.39391264
8ICK3.87264394
9BRD43.70109216
10MAP4K23.55126060
11PLK23.40009390
12PIK3CG2.10006505
13PTK2B1.97305724
14PNCK1.96353915
15WNK41.83644716
16STK391.77514645
17STK381.60247680
18NEK21.59242397
19MST1R1.54778904
20DYRK1B1.28331811
21TTK1.27246287
22CDK71.24895723
23EEF2K1.19991305
24PLK41.13436746
25MUSK1.10059647
26PDK11.08551374
27TYRO31.07056033
28STK38L0.91462684
29CAMK1D0.88017577
30CHEK20.87937611
31STK30.84699069
32AKT30.81008443
33MAP3K110.75527807
34PRKG20.74168415
35CDC70.72763834
36DYRK30.72597036
37BRAF0.68571890
38UHMK10.66407258
39WNK10.63262908
40SIK20.63034511
41RPS6KA20.62210850
42MAP3K20.61498953
43LATS10.61141196
44PDPK10.59485396
45MAP2K20.58514370
46MAPK150.57172531
47CAMK1G0.56184446
48TAOK10.55747929
49IRAK10.55093024
50MAP2K60.53721135
51LMTK20.53164736
52MAP3K60.52558426
53CAMK10.52196954
54CHEK10.50168238
55ROCK10.47185613
56TIE10.46500492
57MAPKAPK50.45790890
58MARK10.44887981
59CCNB10.44182264
60ERBB40.44124483
61PAK10.43205745
62LATS20.42786419
63MARK20.41487151
64NTRK20.40769749
65MAPK10.39519834
66PASK0.38991118
67PINK10.38584340
68PLK10.37633719
69SGK2230.36995073
70SGK4940.36995073
71ATM0.36541577
72TESK20.36361279
73RIPK40.35681177
74CAMK40.35255296
75PAK60.35153422
76NTRK30.34653862
77BMPR1B0.33189287
78RPS6KL10.31122140
79RPS6KC10.31122140
80STK100.30392262
81PRKAA10.29910342
82MTOR0.28466538
83RPS6KA60.28241204
84ARAF0.27687443
85SGK10.26182999
86MAPKAPK30.24549834
87KSR20.23037942
88ATR0.22988667
89NEK60.22936626
90WEE10.22414449
91MAPK140.22213230
92PAK20.22142618
93IRAK20.21631774
94TAOK30.20900812
95PRKCB0.20806451
96BLK0.20762640
97MAPK100.20702533
98CDK120.20633160
99BRSK20.19685850
100AKT10.16540223
101MAPK110.15909694
102PRKCG0.14445972
103PKN10.13222443
104MELK0.13010786
105MAP3K40.12949713
106MET0.12918076
107BRSK10.11313565
108CDK10.10841704
109CSNK1D0.10690389
110CDK150.10520390
111MAP3K50.10486168
112PRKCZ0.10441800
113GSK3B0.10051378
114CDK20.09826658
115PRKACB0.09733514
116OXSR10.09575352
117JAK30.09089250
118MOS0.09017445
119MAP3K90.09005901
120FER0.08758686
121AURKA0.08454111
122TNIK0.08138709
123CAMK2A0.07898587
124SGK20.07825460
125CDK180.07731653
126PRKACA0.07499216
127RPS6KB10.07440031
128MAP3K70.07202184
129FRK0.07015064
130PRKCQ0.06317734
131CDK11A0.06257913
132PAK40.05979859
133MAPK90.05946965
134CDK90.05601532
135AURKB0.05063390
136IKBKB0.04343514
137RPS6KA10.04057639
138CDK30.03828637
139PRKAA20.03757266
140CHUK0.03683604
141CDK40.02698556
142CSNK2A10.02290653
143STK110.02227241
144CAMKK10.01503777
145PRKG10.01166592
146CDK140.00992967
147MAP3K10.00512738
148RPS6KA3-0.0086185
149CDK6-0.0066786
150MAPK8-0.0049683
151DYRK2-0.0025348
152MAP3K8-0.0002791

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.88598405
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.48069456
3Fatty acid biosynthesis_Homo sapiens_hsa000614.21551897
4Vitamin B6 metabolism_Homo sapiens_hsa007503.97992082
5Olfactory transduction_Homo sapiens_hsa047403.90253335
6Pyruvate metabolism_Homo sapiens_hsa006203.36279660
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26307033
8Linoleic acid metabolism_Homo sapiens_hsa005913.16033543
9Basal transcription factors_Homo sapiens_hsa030222.86836895
10Butanoate metabolism_Homo sapiens_hsa006502.60323418
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55849783
12Glucagon signaling pathway_Homo sapiens_hsa049222.39804376
13Propanoate metabolism_Homo sapiens_hsa006402.39344482
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.32436351
15Oocyte meiosis_Homo sapiens_hsa041142.20560200
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17969215
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03884511
18Dorso-ventral axis formation_Homo sapiens_hsa043201.99818093
19Type I diabetes mellitus_Homo sapiens_hsa049401.93667984
20Allograft rejection_Homo sapiens_hsa053301.92904624
21Glycerolipid metabolism_Homo sapiens_hsa005611.90498140
22Autoimmune thyroid disease_Homo sapiens_hsa053201.87026757
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.83244568
24Fanconi anemia pathway_Homo sapiens_hsa034601.77569385
25Graft-versus-host disease_Homo sapiens_hsa053321.75556547
26Ether lipid metabolism_Homo sapiens_hsa005651.75221022
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.65315229
28Type II diabetes mellitus_Homo sapiens_hsa049301.65145550
29PPAR signaling pathway_Homo sapiens_hsa033201.62954980
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.62185372
31Phenylalanine metabolism_Homo sapiens_hsa003601.62091184
32Selenocompound metabolism_Homo sapiens_hsa004501.60116089
33Mineral absorption_Homo sapiens_hsa049781.53746112
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45016745
35Viral myocarditis_Homo sapiens_hsa054161.40732364
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36387479
37mRNA surveillance pathway_Homo sapiens_hsa030151.32134747
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28789331
39RNA transport_Homo sapiens_hsa030131.27571301
40Arginine and proline metabolism_Homo sapiens_hsa003301.25597577
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.24897694
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23124904
43Fructose and mannose metabolism_Homo sapiens_hsa000511.20386366
44Pentose phosphate pathway_Homo sapiens_hsa000301.18853375
45Amphetamine addiction_Homo sapiens_hsa050311.17510629
46Purine metabolism_Homo sapiens_hsa002301.12344796
47Carbon metabolism_Homo sapiens_hsa012001.09370887
48Fatty acid metabolism_Homo sapiens_hsa012121.07851175
49Fatty acid degradation_Homo sapiens_hsa000711.07570641
50Fat digestion and absorption_Homo sapiens_hsa049751.01333944
51Antigen processing and presentation_Homo sapiens_hsa046121.00052628
52Phototransduction_Homo sapiens_hsa047440.98637084
53Cell cycle_Homo sapiens_hsa041100.94627407
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94626410
55Cardiac muscle contraction_Homo sapiens_hsa042600.93280499
56Influenza A_Homo sapiens_hsa051640.92428881
57Arginine biosynthesis_Homo sapiens_hsa002200.91429425
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90985968
59Estrogen signaling pathway_Homo sapiens_hsa049150.86641780
60Hedgehog signaling pathway_Homo sapiens_hsa043400.86234120
61RNA degradation_Homo sapiens_hsa030180.86019205
62Huntingtons disease_Homo sapiens_hsa050160.84801824
63Arachidonic acid metabolism_Homo sapiens_hsa005900.83601407
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83560084
65Glutathione metabolism_Homo sapiens_hsa004800.81342726
66Ovarian steroidogenesis_Homo sapiens_hsa049130.81015964
67Renin secretion_Homo sapiens_hsa049240.80617792
68Biosynthesis of amino acids_Homo sapiens_hsa012300.78574082
69Morphine addiction_Homo sapiens_hsa050320.78219798
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73382968
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71637766
72Insulin secretion_Homo sapiens_hsa049110.71438266
73Thyroid hormone synthesis_Homo sapiens_hsa049180.70775942
74Nicotine addiction_Homo sapiens_hsa050330.69740101
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69617096
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68907161
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.68392464
78Bile secretion_Homo sapiens_hsa049760.67984816
79Inositol phosphate metabolism_Homo sapiens_hsa005620.67274489
80Tyrosine metabolism_Homo sapiens_hsa003500.65976227
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64624480
82Collecting duct acid secretion_Homo sapiens_hsa049660.62141549
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.61384787
84Chemical carcinogenesis_Homo sapiens_hsa052040.59251478
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.59229804
86Retinol metabolism_Homo sapiens_hsa008300.57137149
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56152773
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54139082
89Long-term potentiation_Homo sapiens_hsa047200.53914699
90VEGF signaling pathway_Homo sapiens_hsa043700.52141931
91Protein digestion and absorption_Homo sapiens_hsa049740.50049245
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.48449807
93Acute myeloid leukemia_Homo sapiens_hsa052210.46310312
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46161154
95MAPK signaling pathway_Homo sapiens_hsa040100.45707654
96Endocytosis_Homo sapiens_hsa041440.45552357
97AMPK signaling pathway_Homo sapiens_hsa041520.45288827
98Salivary secretion_Homo sapiens_hsa049700.41970339
99Calcium signaling pathway_Homo sapiens_hsa040200.41055943
100cAMP signaling pathway_Homo sapiens_hsa040240.39935207
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.39381868
102Legionellosis_Homo sapiens_hsa051340.39226144
103Pancreatic secretion_Homo sapiens_hsa049720.38928773
104Serotonergic synapse_Homo sapiens_hsa047260.37189431
105Pyrimidine metabolism_Homo sapiens_hsa002400.35470127
106Gastric acid secretion_Homo sapiens_hsa049710.34742410
107Tight junction_Homo sapiens_hsa045300.33341784
108Metabolic pathways_Homo sapiens_hsa011000.31238227
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.31095977
110Renin-angiotensin system_Homo sapiens_hsa046140.30664925
111Cholinergic synapse_Homo sapiens_hsa047250.30217730
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30057271
113Taste transduction_Homo sapiens_hsa047420.29245761
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27788134
115Herpes simplex infection_Homo sapiens_hsa051680.26925077
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26589687
117Synaptic vesicle cycle_Homo sapiens_hsa047210.26439893
118Viral carcinogenesis_Homo sapiens_hsa052030.25679646
119Homologous recombination_Homo sapiens_hsa034400.25530150
120ECM-receptor interaction_Homo sapiens_hsa045120.23704443
121ABC transporters_Homo sapiens_hsa020100.23447293
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22864807
123Nitrogen metabolism_Homo sapiens_hsa009100.22811060
124Oxytocin signaling pathway_Homo sapiens_hsa049210.22154873
125GABAergic synapse_Homo sapiens_hsa047270.21961656
126Prolactin signaling pathway_Homo sapiens_hsa049170.20018151
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19285440
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18231358
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17457805
130Circadian entrainment_Homo sapiens_hsa047130.15850723
131Cocaine addiction_Homo sapiens_hsa050300.14855082
132Toxoplasmosis_Homo sapiens_hsa051450.13811545
133Wnt signaling pathway_Homo sapiens_hsa043100.13176583
134Non-homologous end-joining_Homo sapiens_hsa034500.13118302
135Systemic lupus erythematosus_Homo sapiens_hsa053220.11724477
136Sphingolipid metabolism_Homo sapiens_hsa006000.11494935
137Circadian rhythm_Homo sapiens_hsa047100.11440834
138Glutamatergic synapse_Homo sapiens_hsa047240.11161821
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09922013
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09005469
141HIF-1 signaling pathway_Homo sapiens_hsa040660.05993914

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