TWSG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.96458133
2Golgi transport vesicle coating (GO:0048200)8.96458133
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.94644642
4COPII vesicle coating (GO:0048208)5.33149574
5protein retention in ER lumen (GO:0006621)5.27924674
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.20976919
7skin morphogenesis (GO:0043589)5.12867623
8type B pancreatic cell proliferation (GO:0044342)4.86458910
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.84728222
10type B pancreatic cell development (GO:0003323)4.76349553
11cell adhesion mediated by integrin (GO:0033627)4.74597245
12positive regulation of nuclease activity (GO:0032075)4.64247811
13exocrine pancreas development (GO:0031017)4.60883658
14sequestering of extracellular ligand from receptor (GO:0035581)4.53614865
15glandular epithelial cell development (GO:0002068)4.40969671
16endocrine pancreas development (GO:0031018)4.40602167
17endodermal cell differentiation (GO:0035987)4.36474127
18chondrocyte proliferation (GO:0035988)4.35091588
19cellular response to vitamin D (GO:0071305)4.33683737
20mesenchymal-epithelial cell signaling (GO:0060638)4.28239532
21regulation of nuclease activity (GO:0032069)4.18994665
22endoplasmic reticulum unfolded protein response (GO:0030968)4.14445504
23positive regulation of hormone biosynthetic process (GO:0046886)4.09334210
24kidney mesenchyme development (GO:0072074)4.08761693
25vesicle coating (GO:0006901)4.00686895
26cellular response to unfolded protein (GO:0034620)4.00264317
27peptide hormone processing (GO:0016486)3.98940458
28ER-nucleus signaling pathway (GO:0006984)3.88442028
29extracellular matrix assembly (GO:0085029)3.85008327
30bone trabecula formation (GO:0060346)3.84148526
31extracellular fibril organization (GO:0043206)3.82422239
32cell migration involved in heart development (GO:0060973)3.82407677
33cellular response to vitamin (GO:0071295)3.76015829
34negative regulation of chondrocyte differentiation (GO:0032331)3.75199484
35cellular response to topologically incorrect protein (GO:0035967)3.74269940
36sequestering of metal ion (GO:0051238)3.72731590
37metanephric mesenchyme development (GO:0072075)3.70539302
38protein maturation by protein folding (GO:0022417)3.64266498
39mesodermal cell differentiation (GO:0048333)3.60903166
40toxin metabolic process (GO:0009404)3.57746211
41glandular epithelial cell differentiation (GO:0002067)3.56124401
42endocardial cushion development (GO:0003197)3.51258951
43collagen metabolic process (GO:0032963)3.48986455
44regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.46607469
45columnar/cuboidal epithelial cell development (GO:0002066)3.46583595
46positive regulation of endothelial cell apoptotic process (GO:2000353)3.45833047
474-hydroxyproline metabolic process (GO:0019471)3.45658130
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39665766
49muscle cell migration (GO:0014812)3.36965588
50blood vessel maturation (GO:0001955)3.35388883
51regulation of integrin-mediated signaling pathway (GO:2001044)3.34125888
52collagen catabolic process (GO:0030574)3.32377622
53wound healing, spreading of epidermal cells (GO:0035313)3.29226026
54regulation of type B pancreatic cell apoptotic process (GO:2000674)3.23787409
55response to endoplasmic reticulum stress (GO:0034976)3.23718077
56substrate-dependent cell migration (GO:0006929)3.20234561
57negative regulation of smooth muscle cell migration (GO:0014912)3.19732084
58multicellular organismal macromolecule metabolic process (GO:0044259)3.19280701
59heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.19029921
60regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.16906647
61endothelial cell morphogenesis (GO:0001886)3.16539295
62paraxial mesoderm development (GO:0048339)3.13587570
63fibril organization (GO:0097435)3.11563101
64negative regulation of osteoblast proliferation (GO:0033689)3.10788402
65ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.10441571
66response to unfolded protein (GO:0006986)3.09406658
67positive regulation of glycogen biosynthetic process (GO:0045725)3.08290762
68extracellular regulation of signal transduction (GO:1900115)3.06749648
69extracellular negative regulation of signal transduction (GO:1900116)3.06749648
70protein localization to cell surface (GO:0034394)3.06254975
71substrate adhesion-dependent cell spreading (GO:0034446)3.01903626
72epithelial cell fate commitment (GO:0072148)3.01870389
73extracellular matrix disassembly (GO:0022617)3.01107351
74dorsal/ventral axis specification (GO:0009950)3.00791783
75multicellular organismal metabolic process (GO:0044236)3.00460356
76positive regulation of osteoblast proliferation (GO:0033690)2.97926302
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.97773998
78multicellular organismal catabolic process (GO:0044243)2.96940433
79protein localization to endosome (GO:0036010)2.96111428
80hypotonic response (GO:0006971)2.95146263
81response to topologically incorrect protein (GO:0035966)2.93583008
82pericardium development (GO:0060039)2.92327060
83retina vasculature morphogenesis in camera-type eye (GO:0061299)2.92224537
84negative regulation of stem cell proliferation (GO:2000647)2.89161792
85regulation of osteoblast proliferation (GO:0033688)2.88907651
86negative regulation of axon extension involved in axon guidance (GO:0048843)2.87870061
87cell-substrate junction assembly (GO:0007044)2.87247020
88positive regulation of hormone metabolic process (GO:0032352)2.87125072
89Golgi organization (GO:0007030)2.86737329
90positive regulation of histone deacetylation (GO:0031065)2.86687438
91regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.85821708
92smooth muscle tissue development (GO:0048745)2.85544388
93positive regulation of glycolytic process (GO:0045821)2.84084466
94dermatan sulfate biosynthetic process (GO:0030208)2.83297857
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82909585
96collagen fibril organization (GO:0030199)2.82423049
97positive regulation of insulin secretion (GO:0032024)2.79658496
98negative regulation of fatty acid transport (GO:2000192)2.79559529
99keratan sulfate catabolic process (GO:0042340)2.79380010
100hippo signaling (GO:0035329)2.79028495
101virion attachment to host cell (GO:0019062)2.76711473
102adhesion of symbiont to host cell (GO:0044650)2.76711473
103axon extension involved in axon guidance (GO:0048846)2.76540827
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.76540827
105extracellular matrix organization (GO:0030198)2.75974134
106basement membrane organization (GO:0071711)2.75572581
107extracellular structure organization (GO:0043062)2.74899586
108wound healing, spreading of cells (GO:0044319)2.73485768
109barbed-end actin filament capping (GO:0051016)2.73083739
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72797400
111regulation of glucose import in response to insulin stimulus (GO:2001273)2.72540974
112peptidyl-asparagine modification (GO:0018196)2.72540878
113signal peptide processing (GO:0006465)2.72017905
114protein N-linked glycosylation via asparagine (GO:0018279)2.71236919
115hyaluronan catabolic process (GO:0030214)2.70573968
116chondrocyte development (GO:0002063)2.69675741
117cellular response to nutrient (GO:0031670)2.69543214
118ER overload response (GO:0006983)2.69358253
119positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69127398
120membrane raft organization (GO:0031579)2.68893427
121growth hormone secretion (GO:0030252)2.67991343
122L-alpha-amino acid transmembrane transport (GO:1902475)2.67127122
123negative regulation of glycoprotein biosynthetic process (GO:0010561)2.66646637
124protein hydroxylation (GO:0018126)2.66495924
125ER to Golgi vesicle-mediated transport (GO:0006888)2.66368116
126glomerular basement membrane development (GO:0032836)2.66099141
127regulation of establishment of planar polarity (GO:0090175)2.64760764
128regulation of transforming growth factor beta2 production (GO:0032909)2.63811975
129tricarboxylic acid metabolic process (GO:0072350)2.63215880
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.61331779
131regulation of secondary heart field cardioblast proliferation (GO:0003266)2.61166144
132regulation of cardioblast proliferation (GO:0003264)2.61166144
133positive regulation of Rho protein signal transduction (GO:0035025)2.60716977
134negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.60017103
135dermatan sulfate metabolic process (GO:0030205)2.59734724
136sprouting angiogenesis (GO:0002040)2.58720353
137hemidesmosome assembly (GO:0031581)2.58505138
138stress fiber assembly (GO:0043149)2.57549285
139apoptotic cell clearance (GO:0043277)2.56511268
140positive regulation of fibroblast migration (GO:0010763)2.55389346
141establishment of planar polarity (GO:0001736)2.54601452
142macroautophagy (GO:0016236)2.52272047
143intra-Golgi vesicle-mediated transport (GO:0006891)2.51442154
144positive regulation of steroid biosynthetic process (GO:0010893)2.50635557
145regulation of glucan biosynthetic process (GO:0010962)2.48659711
146regulation of glycogen biosynthetic process (GO:0005979)2.48659711
147positive regulation of glycogen metabolic process (GO:0070875)2.48579856
148UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45996699
149negative regulation of glycogen biosynthetic process (GO:0045719)2.45774059
150protein N-linked glycosylation (GO:0006487)2.45569322
151vascular endothelial growth factor signaling pathway (GO:0038084)2.44971066
152desmosome organization (GO:0002934)2.44535678
153growth hormone receptor signaling pathway (GO:0060396)2.43968395
154polarized epithelial cell differentiation (GO:0030859)2.43545120
155insulin secretion (GO:0030073)2.40433456
156protein heterotrimerization (GO:0070208)2.40417825
157regulation of cell fate specification (GO:0042659)2.39922680
158astrocyte differentiation (GO:0048708)2.38480547
159lung vasculature development (GO:0060426)2.37883408
160positive regulation of p38MAPK cascade (GO:1900745)2.37335684
161regulation of polysaccharide biosynthetic process (GO:0032885)2.36424580
162body morphogenesis (GO:0010171)2.36317113
163cell migration involved in sprouting angiogenesis (GO:0002042)2.32743509
164cellular zinc ion homeostasis (GO:0006882)2.32036636
165regulation of cholesterol homeostasis (GO:2000188)2.31831776
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29232446
167regulation of endothelial cell chemotaxis (GO:2001026)2.28993002
168regulation of insulin secretion (GO:0050796)2.28532648
169positive regulation of fatty acid beta-oxidation (GO:0032000)2.28332534
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.28162146
171peptidyl-proline hydroxylation (GO:0019511)2.27540454
172negative regulation of cartilage development (GO:0061037)2.26018277
173glucocorticoid receptor signaling pathway (GO:0042921)2.25015989
174induction of positive chemotaxis (GO:0050930)2.24799552
175membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.24450019
176intestinal epithelial cell development (GO:0060576)2.24373181
177regulation of hormone biosynthetic process (GO:0046885)2.24257216
178embryonic retina morphogenesis in camera-type eye (GO:0060059)2.24038770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.14098118
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.90424939
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.68244979
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.99833461
5CLOCK_20551151_ChIP-Seq_293T_Human3.73689555
6GATA1_22025678_ChIP-Seq_K562_Human3.26686617
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96659952
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.89477492
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.62720745
10AR_21909140_ChIP-Seq_LNCAP_Human2.62648217
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.57101574
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52807537
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.49566418
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48039396
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.36803929
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.35465651
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23345521
18* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.16214004
19TP53_18474530_ChIP-ChIP_U2OS_Human2.13151280
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09556246
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01603931
22SOX2_27498859_Chip-Seq_STOMACH_Mouse2.00054776
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.95037106
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86208447
25ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.78484074
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78199266
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77540276
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.76428689
29FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.75146489
30NFIB_24661679_ChIP-Seq_LUNG_Mouse1.71547995
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.71068442
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68897594
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68578721
34* EP300_21415370_ChIP-Seq_HL-1_Mouse1.68561923
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66824854
36TBX20_22328084_ChIP-Seq_HEART_Mouse1.65370239
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.65370239
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64698180
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64138277
40TP53_16413492_ChIP-PET_HCT116_Human1.62416264
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60562802
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60396639
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59342627
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58988625
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58464567
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55792781
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55761991
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55045849
49* BRD4_25478319_ChIP-Seq_HGPS_Human1.53574203
50CJUN_26792858_Chip-Seq_BT549_Human1.53237748
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51735061
52* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50920806
53SOX2_20726797_ChIP-Seq_SW620_Human1.50264155
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50123510
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49631689
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48465397
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48414965
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47883575
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.47821528
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46781220
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46123056
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42734632
63FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41918792
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41546104
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41107944
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39904817
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.39281925
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38340595
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.37510071
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36571426
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33651668
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33297340
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.30723809
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.30627538
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30316116
76ZNF263_19887448_ChIP-Seq_K562_Human1.30178851
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29891948
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29831000
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29650232
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.29369491
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29108494
82CHD1_26751641_Chip-Seq_LNCaP_Human1.28841600
83* SA1_22415368_ChIP-Seq_MEFs_Mouse1.27858581
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.27529897
85GATA4_25053715_ChIP-Seq_YYC3_Human1.26941758
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25572699
87* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24177733
88GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23611866
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23360185
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23360185
91GATA6_25053715_ChIP-Seq_YYC3_Human1.23089829
92TP53_22127205_ChIP-Seq_IMR90_Human1.23075488
93ATF3_27146783_Chip-Seq_COLON_Human1.20318233
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.19992477
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19981175
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19981175
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18644659
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18365234
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15320029
100RACK7_27058665_Chip-Seq_MCF-7_Human1.15083122
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15070126
102* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.14626456
103SOX17_20123909_ChIP-Seq_XEN_Mouse1.14179379
104FOXA1_25552417_ChIP-Seq_VCAP_Human1.11779187
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11724543
106* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09390739
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09167532
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07268481
109EOMES_21245162_ChIP-Seq_HESCs_Human1.07113404
110E2F7_22180533_ChIP-Seq_HELA_Human1.06583871
111* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06479119
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05722866
113NFI_21473784_ChIP-Seq_ESCs_Mouse1.04449235
114TP63_23658742_ChIP-Seq_EP156T_Human1.03744586
115CREB1_26743006_Chip-Seq_LNCaP_Human1.00727187
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99826532
117EED_16625203_ChIP-ChIP_MESCs_Mouse0.99196443
118* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99059926
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97655008
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97476958
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97118150
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.97110769
123ELK1_19687146_ChIP-ChIP_HELA_Human0.96235921
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93993875
125KDM2B_26808549_Chip-Seq_K562_Human0.93979036
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93965485
127* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93384200
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92942578
129GATA1_19941826_ChIP-Seq_K562_Human0.92716462
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92070951
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91995908
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91679748
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90593199
134KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90377654
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.90371049
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89905791
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87176668
138* TP53_23651856_ChIP-Seq_MEFs_Mouse0.85804007
139TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85044920
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84852221
141PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.84130923
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81269644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.90551624
2MP0003283_abnormal_digestive_organ3.25717973
3MP0008438_abnormal_cutaneous_collagen2.80567754
4MP0003195_calcinosis2.75657226
5MP0000013_abnormal_adipose_tissue2.73724803
6MP0009780_abnormal_chondrocyte_physiolo2.70845731
7MP0003705_abnormal_hypodermis_morpholog2.64549106
8MP0006054_spinal_hemorrhage2.62413525
9MP0001542_abnormal_bone_strength2.60404141
10MP0003950_abnormal_plasma_membrane2.47776097
11MP0005275_abnormal_skin_tensile2.46660433
12MP0005503_abnormal_tendon_morphology2.46308665
13MP0000678_abnormal_parathyroid_gland2.44068760
14MP0002909_abnormal_adrenal_gland2.41070494
15MP0001944_abnormal_pancreas_morphology2.36812142
16MP0003300_gastrointestinal_ulcer2.22070449
17MP0005220_abnormal_exocrine_pancreas2.16361942
18MP0002693_abnormal_pancreas_physiology2.12871463
19MP0010234_abnormal_vibrissa_follicle2.05959094
20MP0004043_abnormal_pH_regulation2.05177408
21MP0004272_abnormal_basement_membrane1.98442730
22* MP0002896_abnormal_bone_mineralization1.96147615
23MP0002837_dystrophic_cardiac_calcinosis1.92559434
24MP0000003_abnormal_adipose_tissue1.87379915
25MP0003091_abnormal_cell_migration1.77150855
26MP0004264_abnormal_extraembryonic_tissu1.67510473
27MP0003566_abnormal_cell_adhesion1.67495640
28MP0000767_abnormal_smooth_muscle1.65970389
29MP0003252_abnormal_bile_duct1.63959466
30MP0009384_cardiac_valve_regurgitation1.63695690
31MP0001243_abnormal_dermal_layer1.52425107
32MP0005076_abnormal_cell_differentiation1.50278940
33MP0010352_gastrointestinal_tract_polyps1.46115258
34MP0005248_abnormal_Harderian_gland1.44766125
35MP0001270_distended_abdomen1.40662371
36MP0005187_abnormal_penis_morphology1.38531722
37MP0001299_abnormal_eye_distance/1.35774292
38MP0005379_endocrine/exocrine_gland_phen1.34541944
39MP0002138_abnormal_hepatobiliary_system1.33173816
40MP0000462_abnormal_digestive_system1.32737165
41MP0000516_abnormal_urinary_system1.30534470
42MP0005367_renal/urinary_system_phenotyp1.30534470
43MP0000537_abnormal_urethra_morphology1.28509471
44MP0003122_maternal_imprinting1.28453011
45MP0002078_abnormal_glucose_homeostasis1.26633263
46MP0005257_abnormal_intraocular_pressure1.24860874
47MP0003183_abnormal_peptide_metabolism1.24606953
48* MP0000163_abnormal_cartilage_morphology1.24530674
49MP0002060_abnormal_skin_morphology1.24126730
50MP0003279_aneurysm1.23236659
51MP0002928_abnormal_bile_duct1.22969768
52MP0002139_abnormal_hepatobiliary_system1.22867997
53MP0010368_abnormal_lymphatic_system1.20789657
54MP0010386_abnormal_urinary_bladder1.20023381
55MP0005171_absent_coat_pigmentation1.19543145
56MP0010030_abnormal_orbit_morphology1.19260509
57MP0001849_ear_inflammation1.17649868
58MP0005365_abnormal_bile_salt1.16465118
59MP0000751_myopathy1.14968647
60MP0005197_abnormal_uvea_morphology1.14836107
61* MP0005508_abnormal_skeleton_morphology1.14418716
62MP0005375_adipose_tissue_phenotype1.12975087
63MP0009053_abnormal_anal_canal1.12564982
64MP0009643_abnormal_urine_homeostasis1.11100610
65MP0000534_abnormal_ureter_morphology1.10857408
66MP0008961_abnormal_basal_metabolism1.10365377
67MP0001346_abnormal_lacrimal_gland1.09296883
68MP0004134_abnormal_chest_morphology1.07326873
69* MP0003942_abnormal_urinary_system1.05918191
70MP0005595_abnormal_vascular_smooth1.04980368
71MP0002168_other_aberrant_phenotype1.04870152
72MP0004084_abnormal_cardiac_muscle1.03267197
73MP0001756_abnormal_urination1.00397628
74* MP0000428_abnormal_craniofacial_morphol0.99594455
75MP0002108_abnormal_muscle_morphology0.97703596
76MP0001879_abnormal_lymphatic_vessel0.96797743
77* MP0000432_abnormal_head_morphology0.95016610
78MP0003045_fibrosis0.94911911
79* MP0002115_abnormal_skeleton_extremities0.94387442
80* MP0003935_abnormal_craniofacial_develop0.94123390
81MP0009250_abnormal_appendicular_skeleto0.93921506
82MP0005023_abnormal_wound_healing0.90964550
83MP0004185_abnormal_adipocyte_glucose0.90784859
84MP0003115_abnormal_respiratory_system0.87315781
85MP0001661_extended_life_span0.87306325
86MP0001765_abnormal_ion_homeostasis0.86971080
87MP0001348_abnormal_lacrimal_gland0.86778012
88MP0001958_emphysema0.86333980
89MP0002254_reproductive_system_inflammat0.85798360
90MP0003937_abnormal_limbs/digits/tail_de0.85507919
91MP0005193_abnormal_anterior_eye0.85393536
92* MP0005390_skeleton_phenotype0.84379944
93MP0002098_abnormal_vibrissa_morphology0.83725289
94* MP0002128_abnormal_blood_circulation0.82852560
95MP0000733_abnormal_muscle_development0.82512889
96* MP0003795_abnormal_bone_structure0.80831495
97MP0005623_abnormal_meninges_morphology0.79891804
98MP0009703_decreased_birth_body0.79740714
99MP0000538_abnormal_urinary_bladder0.79520237
100MP0009672_abnormal_birth_weight0.79321850
101MP0003448_altered_tumor_morphology0.77967444
102MP0009697_abnormal_copulation0.77936665
103* MP0002177_abnormal_outer_ear0.77894096
104MP0001666_abnormal_nutrient_absorption0.76941519
105MP0002938_white_spotting0.75677163
106MP0001915_intracranial_hemorrhage0.75296054
107MP0005164_abnormal_response_to0.74378351
108MP0001614_abnormal_blood_vessel0.74345950
109MP0002295_abnormal_pulmonary_circulatio0.73999619
110MP0000049_abnormal_middle_ear0.73806786
111* MP0002113_abnormal_skeleton_development0.72630296
112MP0003868_abnormal_feces_composition0.72448906
113MP0002282_abnormal_trachea_morphology0.72256471
114MP0002932_abnormal_joint_morphology0.71288483
115MP0003959_abnormal_lean_body0.71030905
116MP0003123_paternal_imprinting0.70779096
117MP0010678_abnormal_skin_adnexa0.70062349
118MP0003385_abnormal_body_wall0.69950700
119* MP0002116_abnormal_craniofacial_bone0.69468024
120MP0000749_muscle_degeneration0.69240450
121MP0003941_abnormal_skin_development0.69128886
122MP0003755_abnormal_palate_morphology0.68294498
123MP0005666_abnormal_adipose_tissue0.68009865
124MP0000762_abnormal_tongue_morphology0.66864920
125* MP0002233_abnormal_nose_morphology0.66509337
126MP0004036_abnormal_muscle_relaxation0.65018603
127* MP0001175_abnormal_lung_morphology0.64686770
128MP0008932_abnormal_embryonic_tissue0.64443645
129MP0004197_abnormal_fetal_growth/weight/0.64438287
130MP0005165_increased_susceptibility_to0.62847904
131MP0000759_abnormal_skeletal_muscle0.62256147
132MP0008004_abnormal_stomach_pH0.62149509
133MP0010771_integument_phenotype0.60437500
134MP0004233_abnormal_muscle_weight0.59414506
135MP0000467_abnormal_esophagus_morphology0.59404934
136* MP0002109_abnormal_limb_morphology0.59315364
137* MP0002114_abnormal_axial_skeleton0.59209248
138MP0002925_abnormal_cardiovascular_devel0.58677922
139MP0004858_abnormal_nervous_system0.57318253
140MP0005621_abnormal_cell_physiology0.56617371
141* MP0002092_abnormal_eye_morphology0.54809675
142MP0002133_abnormal_respiratory_system0.52709790
143MP0005388_respiratory_system_phenotype0.52709790
144* MP0002697_abnormal_eye_size0.52392746
145MP0005501_abnormal_skin_physiology0.51884096
146MP0006138_congestive_heart_failure0.51670416
147MP0002084_abnormal_developmental_patter0.51539440

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.09981786
2Vascular tortuosity (HP:0004948)4.92375226
3Hypoglycemic coma (HP:0001325)4.67298575
4Hypoglycemic seizures (HP:0002173)4.60714342
5Follicular hyperkeratosis (HP:0007502)4.45369471
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.45271982
7Arterial tortuosity (HP:0005116)4.34260409
8Symptomatic seizures (HP:0011145)3.97354267
9Hyperglycemia (HP:0003074)3.83866471
10Abnormality of dentin (HP:0010299)3.66639217
11Abnormality of the pancreatic islet cells (HP:0006476)3.51131469
12Abnormality of endocrine pancreas physiology (HP:0012093)3.51131469
13Pancreatic islet-cell hyperplasia (HP:0004510)3.47820314
14Neonatal short-limb short stature (HP:0008921)3.38843875
15Ketoacidosis (HP:0001993)3.36469459
16Insulin-resistant diabetes mellitus (HP:0000831)3.34676578
17Spondylolisthesis (HP:0003302)3.24413387
18Type 1 muscle fiber predominance (HP:0003803)3.23613635
19Protrusio acetabuli (HP:0003179)3.10571263
20Vertebral compression fractures (HP:0002953)3.08813247
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.06547557
22Osteolytic defects of the hand bones (HP:0009699)3.06547557
23Cervical subluxation (HP:0003308)2.95902160
24Genu recurvatum (HP:0002816)2.95263680
25Bowel diverticulosis (HP:0005222)2.94534071
26Abnormal pancreas size (HP:0012094)2.90879734
27Large for gestational age (HP:0001520)2.77832921
28Coronal craniosynostosis (HP:0004440)2.75858342
29Late onset (HP:0003584)2.73981088
30Slender build (HP:0001533)2.73553389
31Overgrowth (HP:0001548)2.61577119
32Hypokalemia (HP:0002900)2.61407040
33Abnormality of calcium-phosphate metabolism (HP:0100530)2.59524802
34Thoracolumbar scoliosis (HP:0002944)2.57565188
35Joint laxity (HP:0001388)2.55114045
36Cerebral aneurysm (HP:0004944)2.54918252
37Premature rupture of membranes (HP:0001788)2.53892281
38Aortic regurgitation (HP:0001659)2.53724121
39Abnormality of the acetabulum (HP:0003170)2.53636641
40Wide anterior fontanel (HP:0000260)2.50511099
41Elbow flexion contracture (HP:0002987)2.50163104
42Urinary glycosaminoglycan excretion (HP:0003541)2.49882191
43Mucopolysacchariduria (HP:0008155)2.49882191
44Right ventricular cardiomyopathy (HP:0011663)2.46426919
45Atrophic scars (HP:0001075)2.43997837
46Unilateral renal agenesis (HP:0000122)2.39626129
47Abnormality of the intrinsic pathway (HP:0010989)2.38494212
48Shallow orbits (HP:0000586)2.35358292
49Hypoplastic ischia (HP:0003175)2.34679696
50Decreased circulating renin level (HP:0003351)2.33748054
51Increased variability in muscle fiber diameter (HP:0003557)2.33684498
52Insulin resistance (HP:0000855)2.32973757
53Short nail (HP:0001799)2.31214498
54Abnormality of the ischium (HP:0003174)2.30843423
55Thin bony cortex (HP:0002753)2.30418580
56Exostoses (HP:0100777)2.29987264
57Epiphyseal dysplasia (HP:0002656)2.29140222
58Peritonitis (HP:0002586)2.28789581
59Ankle contracture (HP:0006466)2.28724393
60Absent frontal sinuses (HP:0002688)2.28644872
61Abnormal delivery (HP:0001787)2.28411290
62Aortic valve stenosis (HP:0001650)2.28228961
63Aneurysm (HP:0002617)2.27191085
64Macroorchidism (HP:0000053)2.24282728
65Wrist flexion contracture (HP:0001239)2.23227517
66Mitral stenosis (HP:0001718)2.21522261
67Hypoplastic labia majora (HP:0000059)2.21285149
68Abnormality of polysaccharide metabolism (HP:0011012)2.19320359
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19320359
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19320359
71Mitral regurgitation (HP:0001653)2.17517150
72Metaphyseal cupping (HP:0003021)2.14271259
73Congenital glaucoma (HP:0001087)2.13881119
74Generalized aminoaciduria (HP:0002909)2.11938772
75Breech presentation (HP:0001623)2.11365244
76Aortic aneurysm (HP:0004942)2.08403435
77Broad metatarsal (HP:0001783)2.07506263
78Abnormality of potassium homeostasis (HP:0011042)2.07372448
79Hepatoblastoma (HP:0002884)2.07043078
80Delayed cranial suture closure (HP:0000270)2.06067523
81Hyperactive renin-angiotensin system (HP:0000841)2.05876721
82Protruding ear (HP:0000411)2.05451102
83Abdominal distention (HP:0003270)2.04849191
84Ulnar bowing (HP:0003031)2.04422350
85Mildly elevated creatine phosphokinase (HP:0008180)2.03725411
86Biconcave vertebral bodies (HP:0004586)2.03703022
87Natal tooth (HP:0000695)2.02272567
88Enlarged penis (HP:0000040)2.01519107
89Delayed closure of the anterior fontanelle (HP:0001476)2.01257375
90Abnormality of the distal phalanges of the toes (HP:0010182)2.01139239
91Lymphangioma (HP:0100764)2.00698950
92Rectal prolapse (HP:0002035)2.00666846
93Abnormality of skeletal muscle fiber size (HP:0012084)1.99731082
94Deviation of the hallux (HP:0010051)1.99707914
95Camptodactyly of toe (HP:0001836)1.98493820
96Protuberant abdomen (HP:0001538)1.97128268
97Turricephaly (HP:0000262)1.96641296
98Cardiovascular calcification (HP:0011915)1.95855179
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.95724792
100Abnormality of skull ossification (HP:0002703)1.94024805
101Abnormality of the labia majora (HP:0012881)1.93207960
102Ketosis (HP:0001946)1.91176758
103Hallux valgus (HP:0001822)1.91009364
104Long toe (HP:0010511)1.88923036
105Decreased skull ossification (HP:0004331)1.88735880
106Hypoventilation (HP:0002791)1.88532057
107Dysostosis multiplex (HP:0000943)1.88409958
108Bladder diverticulum (HP:0000015)1.87828108
109Spinal cord lesions (HP:0100561)1.87774019
110Syringomyelia (HP:0003396)1.87774019
111Inguinal hernia (HP:0000023)1.87446466
112Delayed gross motor development (HP:0002194)1.85733096
113Subacute progressive viral hepatitis (HP:0006572)1.85288402
114Aortic dissection (HP:0002647)1.85028985
115Mild short stature (HP:0003502)1.84699749
116Skin nodule (HP:0200036)1.83919027
117Hydroureter (HP:0000072)1.83875890
118Redundant skin (HP:0001582)1.83163321
119Hyperparathyroidism (HP:0000843)1.81898847
120Disproportionate tall stature (HP:0001519)1.81020370
121Mitral valve prolapse (HP:0001634)1.80593428
122Limb-girdle muscle weakness (HP:0003325)1.80107352
123Abnormality of chloride homeostasis (HP:0011422)1.80030457
124Generalized amyotrophy (HP:0003700)1.79663114
125Entropion (HP:0000621)1.79621517
126Severe short stature (HP:0003510)1.79286592
127Back pain (HP:0003418)1.79277875
128Platyspondyly (HP:0000926)1.78993754
129Nonimmune hydrops fetalis (HP:0001790)1.78945679
130Ectopia lentis (HP:0001083)1.77967402
131Broad ribs (HP:0000885)1.77645626
132Buphthalmos (HP:0000557)1.75955923
133Bronchomalacia (HP:0002780)1.75891584
134Abnormality of the common coagulation pathway (HP:0010990)1.75683114
135Asymmetry of the thorax (HP:0001555)1.75154540
136Abnormality of renin-angiotensin system (HP:0000847)1.75114388
137Knee flexion contracture (HP:0006380)1.74124079
138Agitation (HP:0000713)1.74037919
139Renal duplication (HP:0000075)1.72377526
140Joint stiffness (HP:0001387)1.71120297
141Abnormality of the umbilical cord (HP:0010881)1.71039211
142Dilatation of the ascending aorta (HP:0005111)1.70962191
143Femoral bowing (HP:0002980)1.70926453
144Hyperkalemia (HP:0002153)1.70907403
145Abnormal umbilical cord blood vessels (HP:0011403)1.70815838
146Single umbilical artery (HP:0001195)1.70815838
147Abnormality of the fetal cardiovascular system (HP:0010948)1.70815838
148Round ear (HP:0100830)1.69203200
149Missing ribs (HP:0000921)1.69123679
150Soft skin (HP:0000977)1.68333708
151Ovoid vertebral bodies (HP:0003300)1.66833127
152Blue sclerae (HP:0000592)1.66634591
153Osteopenia (HP:0000938)1.64977113
154Coxa vara (HP:0002812)1.64297193
155Tibial bowing (HP:0002982)1.63355145
156Osteomalacia (HP:0002749)1.63316029
157Increased mean platelet volume (HP:0011877)1.63134139
158Abnormal foot bone ossification (HP:0010675)1.62556502
159Hypercortisolism (HP:0001578)1.62076894
160Osteoarthritis (HP:0002758)1.61244349
161Spinal rigidity (HP:0003306)1.60655509
162Hypoplasia of the iris (HP:0007676)1.59618279
163Gout (HP:0001997)1.58974696
164Flat acetabular roof (HP:0003180)1.58828289
165Enlarged epiphyses (HP:0010580)1.57128236
166Hematochezia (HP:0002573)1.56970254
167Hypokalemic alkalosis (HP:0001949)1.56819674
168Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56401486
169Wormian bones (HP:0002645)1.56052059
170Exocrine pancreatic insufficiency (HP:0001738)1.54947861
171Mesomelia (HP:0003027)1.53970896
172Striae distensae (HP:0001065)1.53228010
173Fragile skin (HP:0001030)1.52050331
174Hyperextensible skin (HP:0000974)1.51993432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.03369134
2INSRR4.11857803
3TRIB33.54487731
4PASK3.43757587
5LATS13.19695562
6FRK2.92034832
7MAPK152.91271860
8ERN12.83971939
9PDGFRA2.76884891
10SIK12.48212462
11LIMK12.35889269
12PTK62.25776305
13EPHA32.24694664
14PRKD32.24581532
15MAP3K22.24211065
16TAOK32.06411909
17LATS22.06283432
18PKN22.04184011
19EIF2AK12.03387535
20HIPK21.96486557
21ERBB41.96416571
22DDR21.92191531
23WNK31.88045574
24FLT31.80998951
25TTN1.71534741
26WNK41.70394293
27RIPK11.66195918
28GRK71.59770503
29PTK21.56459813
30FER1.52859770
31MOS1.50137458
32FGFR41.48405141
33MAP3K31.47067322
34MAP3K121.46434475
35SCYL21.46020055
36MET1.26376829
37FGFR31.25666546
38DYRK1B1.23487339
39AKT31.20397916
40NEK11.20208683
41GRK51.19888792
42MAP3K101.18343338
43PAK31.18316484
44CDC42BPA1.17937046
45CDK81.08368873
46PLK21.05725357
47EIF2AK31.04289507
48FGFR21.01764470
49NEK91.01400380
50MAP3K11.01329304
51ERBB31.00986118
52PRKCH1.00567605
53PIM20.99614597
54ABL20.97255739
55PBK0.97231776
56MTOR0.96765468
57STK30.95947644
58TGFBR20.95717269
59PDGFRB0.95514507
60LRRK20.95021843
61ADRBK10.93231506
62BRSK20.92972654
63TTK0.92282044
64PIK3CG0.91102390
65ROCK20.90997769
66PTK2B0.88881396
67DAPK30.88090262
68EPHA20.87928492
69EEF2K0.84095152
70WEE10.82520330
71RPS6KA40.82123913
72BUB10.81892939
73NTRK10.80350524
74EPHB20.77051294
75STK38L0.76451773
76NUAK10.76170105
77NEK20.75807836
78RET0.75763157
79FGFR10.75580168
80JAK10.75234860
81BCKDK0.74402533
82PLK30.73754381
83EPHB10.73705514
84PAK20.73046147
85DMPK0.72335440
86GRK10.72119821
87STK380.70575313
88IRAK30.70274107
89CDK120.70013620
90BCR0.69099228
91PRKD20.68509439
92CDK60.67451633
93JAK20.66585413
94CAMK1D0.63522141
95IRAK10.63038458
96TGFBR10.62956387
97PRKD10.62263106
98BMX0.61529569
99UHMK10.60020980
100MST40.59779281
101CHUK0.59554995
102MAP2K20.58886242
103PAK40.58875466
104LMTK20.58268034
105GSK3A0.58100496
106JAK30.57765455
107WNK10.57460503
108PAK10.57071602
109CAMKK20.55901905
110CAMK1G0.53839134
111PNCK0.53825375
112CLK10.53380196
113PAK60.51123341
114STK100.49312793
115KSR10.48909819
116MAP2K10.48890914
117BRSK10.48112886
118PRKAA10.46554570
119STK240.46495739
120MAPKAPK30.46110149
121CDK90.41445407
122TESK10.41331434
123EIF2AK20.40536100
124IGF1R0.39044450
125MST1R0.38889038
126ADRBK20.38218161
127NLK0.37718372
128ARAF0.36683688
129ITK0.35434957
130AURKB0.35252369
131CAMK2G0.35238428
132CDK70.34937290
133TRPM70.34062224
134TRIM280.33500862
135ERBB20.33279557
136MAP3K80.32623662
137TAF10.32557285
138CHEK20.32536135
139PRKCE0.29277681
140RPS6KA20.29109948
141ROCK10.28767085
142KSR20.28378756
143PIK3CA0.28339370
144ILK0.27303459
145PRKG20.26808868
146PRKCI0.26438069
147TIE10.26100851
148MELK0.25223343
149RPS6KB20.23902703
150SGK30.23039253
151MAPK10.22080230

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.87471588
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.23557949
3Protein export_Homo sapiens_hsa030602.99067800
4Sulfur metabolism_Homo sapiens_hsa009202.84606785
5Insulin secretion_Homo sapiens_hsa049111.93783295
6Regulation of actin cytoskeleton_Homo sapiens_hsa048101.90275559
7Selenocompound metabolism_Homo sapiens_hsa004501.89116972
8Type II diabetes mellitus_Homo sapiens_hsa049301.88773091
9ECM-receptor interaction_Homo sapiens_hsa045121.82594687
10Melanoma_Homo sapiens_hsa052181.79667073
11Protein digestion and absorption_Homo sapiens_hsa049741.71582923
12p53 signaling pathway_Homo sapiens_hsa041151.67661095
13Insulin resistance_Homo sapiens_hsa049311.65016800
14N-Glycan biosynthesis_Homo sapiens_hsa005101.58910774
15Focal adhesion_Homo sapiens_hsa045101.48738445
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44619220
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39543030
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.38113461
19Tryptophan metabolism_Homo sapiens_hsa003801.37899202
20Adherens junction_Homo sapiens_hsa045201.32648574
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.25930799
22Thyroid hormone synthesis_Homo sapiens_hsa049181.19784916
23Bladder cancer_Homo sapiens_hsa052191.18755108
24Lysine degradation_Homo sapiens_hsa003101.18387610
25Fatty acid degradation_Homo sapiens_hsa000711.18313459
26Shigellosis_Homo sapiens_hsa051311.15473192
27Proteoglycans in cancer_Homo sapiens_hsa052051.13516489
28Glucagon signaling pathway_Homo sapiens_hsa049221.13222458
29Gap junction_Homo sapiens_hsa045401.11498398
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11194332
31Nucleotide excision repair_Homo sapiens_hsa034201.08603988
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06088782
33Nitrogen metabolism_Homo sapiens_hsa009101.03165773
34Lysosome_Homo sapiens_hsa041420.99624632
35Prolactin signaling pathway_Homo sapiens_hsa049170.99589886
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97994039
37Sphingolipid metabolism_Homo sapiens_hsa006000.97223783
38Type I diabetes mellitus_Homo sapiens_hsa049400.96091625
39Prostate cancer_Homo sapiens_hsa052150.95195308
40Starch and sucrose metabolism_Homo sapiens_hsa005000.94845405
41Amoebiasis_Homo sapiens_hsa051460.93848145
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93070929
43Cell cycle_Homo sapiens_hsa041100.91215466
44Chronic myeloid leukemia_Homo sapiens_hsa052200.91160265
45Hippo signaling pathway_Homo sapiens_hsa043900.90207782
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89229503
47Hedgehog signaling pathway_Homo sapiens_hsa043400.86986615
48Small cell lung cancer_Homo sapiens_hsa052220.86824094
49Basal cell carcinoma_Homo sapiens_hsa052170.85865507
50mTOR signaling pathway_Homo sapiens_hsa041500.85408830
51Vibrio cholerae infection_Homo sapiens_hsa051100.84463219
52Phenylalanine metabolism_Homo sapiens_hsa003600.82871535
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81420468
54Fatty acid elongation_Homo sapiens_hsa000620.81002685
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80952567
56Insulin signaling pathway_Homo sapiens_hsa049100.80138471
57Other glycan degradation_Homo sapiens_hsa005110.79357196
58Thyroid cancer_Homo sapiens_hsa052160.79124098
59Platelet activation_Homo sapiens_hsa046110.79089760
60TGF-beta signaling pathway_Homo sapiens_hsa043500.77266052
61Glutathione metabolism_Homo sapiens_hsa004800.76756989
62Pancreatic secretion_Homo sapiens_hsa049720.76519294
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76310218
64One carbon pool by folate_Homo sapiens_hsa006700.76271142
65Cocaine addiction_Homo sapiens_hsa050300.75876432
66AMPK signaling pathway_Homo sapiens_hsa041520.75237982
67Circadian rhythm_Homo sapiens_hsa047100.74816912
68Dilated cardiomyopathy_Homo sapiens_hsa054140.74711024
69Axon guidance_Homo sapiens_hsa043600.74534244
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73664382
71Estrogen signaling pathway_Homo sapiens_hsa049150.73251284
72Endometrial cancer_Homo sapiens_hsa052130.72296076
73Proteasome_Homo sapiens_hsa030500.72156366
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71704971
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71246459
76Butanoate metabolism_Homo sapiens_hsa006500.71197851
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70266437
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70195276
79Rap1 signaling pathway_Homo sapiens_hsa040150.69806906
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69623063
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68359413
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67457388
83Prion diseases_Homo sapiens_hsa050200.67420235
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.67156316
85ABC transporters_Homo sapiens_hsa020100.66709524
86MicroRNAs in cancer_Homo sapiens_hsa052060.66173449
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66173249
88Pentose phosphate pathway_Homo sapiens_hsa000300.66037173
89Fatty acid metabolism_Homo sapiens_hsa012120.66003416
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65968748
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64710819
92Fat digestion and absorption_Homo sapiens_hsa049750.63778501
93Endocytosis_Homo sapiens_hsa041440.60976179
94Dorso-ventral axis formation_Homo sapiens_hsa043200.60784303
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.60625048
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60259460
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.59092382
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59010649
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57438891
100Pancreatic cancer_Homo sapiens_hsa052120.56955892
101Renal cell carcinoma_Homo sapiens_hsa052110.56678646
102Salmonella infection_Homo sapiens_hsa051320.55941349
103Steroid biosynthesis_Homo sapiens_hsa001000.55491915
104Tyrosine metabolism_Homo sapiens_hsa003500.54555473
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53861740
106Bile secretion_Homo sapiens_hsa049760.53674319
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53223813
108Malaria_Homo sapiens_hsa051440.53163959
109Tight junction_Homo sapiens_hsa045300.52250203
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51815096
111Mismatch repair_Homo sapiens_hsa034300.51596722
112Antigen processing and presentation_Homo sapiens_hsa046120.50294624
113Renin-angiotensin system_Homo sapiens_hsa046140.50244974
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.50119030
115Galactose metabolism_Homo sapiens_hsa000520.49880254
116Ovarian steroidogenesis_Homo sapiens_hsa049130.49361989
117Melanogenesis_Homo sapiens_hsa049160.48124771
118Toxoplasmosis_Homo sapiens_hsa051450.47839024
119Folate biosynthesis_Homo sapiens_hsa007900.47405310
120FoxO signaling pathway_Homo sapiens_hsa040680.47199110
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46494143
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45517443
123Ras signaling pathway_Homo sapiens_hsa040140.45051304
124Vitamin B6 metabolism_Homo sapiens_hsa007500.44527457
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44349891
126HTLV-I infection_Homo sapiens_hsa051660.43404874
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43086342
128Wnt signaling pathway_Homo sapiens_hsa043100.42224582
129Pathways in cancer_Homo sapiens_hsa052000.40051968
130Glioma_Homo sapiens_hsa052140.39932820
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.39847565
132Colorectal cancer_Homo sapiens_hsa052100.39779255
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.38886301
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.38547244
135Non-homologous end-joining_Homo sapiens_hsa034500.38391900
136PPAR signaling pathway_Homo sapiens_hsa033200.38197649
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37250333
138Histidine metabolism_Homo sapiens_hsa003400.37027081
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33959972
140Pyrimidine metabolism_Homo sapiens_hsa002400.33646769
141Complement and coagulation cascades_Homo sapiens_hsa046100.30121684
142Hepatitis B_Homo sapiens_hsa051610.25786536
143Phagosome_Homo sapiens_hsa041450.25063679
144Viral carcinogenesis_Homo sapiens_hsa052030.24633627

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