TWIST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cell migration involved in heart development (GO:0060973)6.85604425
2protein heterotrimerization (GO:0070208)5.96722765
3bone trabecula formation (GO:0060346)5.84475104
4chondrocyte proliferation (GO:0035988)5.46560816
5collagen fibril organization (GO:0030199)5.38698595
6planar cell polarity pathway involved in neural tube closure (GO:0090179)5.30689934
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.09935151
8enteric nervous system development (GO:0048484)4.92202165
9regulation of secondary heart field cardioblast proliferation (GO:0003266)4.79209769
10regulation of cardioblast proliferation (GO:0003264)4.79209769
11axon extension involved in axon guidance (GO:0048846)4.76570232
12neuron projection extension involved in neuron projection guidance (GO:1902284)4.76570232
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.73797081
14sequestering of extracellular ligand from receptor (GO:0035581)4.56924346
15middle ear morphogenesis (GO:0042474)4.42047241
16mesenchymal-epithelial cell signaling (GO:0060638)4.30834050
17paraxial mesoderm development (GO:0048339)4.28886598
18tooth mineralization (GO:0034505)4.25137407
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22423207
20embryonic skeletal joint morphogenesis (GO:0060272)4.19234901
21cell proliferation involved in metanephros development (GO:0072203)4.16153547
22lateral sprouting from an epithelium (GO:0060601)4.09126409
23hippo signaling (GO:0035329)4.08781378
24negative regulation of chondrocyte differentiation (GO:0032331)4.05103505
25mesenchymal cell proliferation (GO:0010463)4.04124024
26regulation of organ formation (GO:0003156)4.02882733
27* embryonic cranial skeleton morphogenesis (GO:0048701)3.99661966
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.94110123
29polarized epithelial cell differentiation (GO:0030859)3.91063843
30kidney mesenchyme development (GO:0072074)3.89502585
31Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.86459271
32metanephric mesenchyme development (GO:0072075)3.83940492
33regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.83668877
34regulation of establishment of planar polarity (GO:0090175)3.80096823
35endodermal cell differentiation (GO:0035987)3.77973128
36proximal/distal pattern formation (GO:0009954)3.76287669
37neural crest cell development (GO:0014032)3.74554542
38collagen metabolic process (GO:0032963)3.68265253
39* outer ear morphogenesis (GO:0042473)3.67062185
40negative regulation of catenin import into nucleus (GO:0035414)3.66913564
41anatomical structure regression (GO:0060033)3.66729698
42* craniofacial suture morphogenesis (GO:0097094)3.66344017
43body morphogenesis (GO:0010171)3.64586645
44dopaminergic neuron differentiation (GO:0071542)3.64154190
45cartilage morphogenesis (GO:0060536)3.59994819
46dermatan sulfate metabolic process (GO:0030205)3.59954109
47regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.59465276
48cochlea morphogenesis (GO:0090103)3.59122366
49negative regulation of cartilage development (GO:0061037)3.59048583
50artery morphogenesis (GO:0048844)3.58749699
51collagen catabolic process (GO:0030574)3.58157650
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.57053476
53chondrocyte development (GO:0002063)3.55929129
54negative regulation of fatty acid transport (GO:2000192)3.54052607
55extracellular matrix assembly (GO:0085029)3.53424374
56regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.53388372
57non-canonical Wnt signaling pathway (GO:0035567)3.53001136
58negative regulation of embryonic development (GO:0045992)3.52567826
59negative regulation of axon extension involved in axon guidance (GO:0048843)3.46627043
60cell proliferation involved in kidney development (GO:0072111)3.45622091
61positive regulation of mesenchymal cell proliferation (GO:0002053)3.42835156
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.42474326
63skin morphogenesis (GO:0043589)3.42351083
64multicellular organismal macromolecule metabolic process (GO:0044259)3.41706576
65anterior/posterior axis specification, embryo (GO:0008595)3.41287422
66keratan sulfate catabolic process (GO:0042340)3.39900549
67head development (GO:0060322)3.38604899
68convergent extension (GO:0060026)3.38461731
69aorta morphogenesis (GO:0035909)3.36259275
70negative regulation of axon guidance (GO:1902668)3.35491010
71negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.33033712
72* embryonic forelimb morphogenesis (GO:0035115)3.29686054
73regulation of cartilage development (GO:0061035)3.28982079
74pattern specification involved in kidney development (GO:0061004)3.28196492
75mesenchymal cell development (GO:0014031)3.27750593
76multicellular organismal catabolic process (GO:0044243)3.23581437
77outflow tract septum morphogenesis (GO:0003148)3.21616147
78regulation of mesenchymal cell proliferation (GO:0010464)3.21430920
79multicellular organismal metabolic process (GO:0044236)3.21285287
80* positive regulation of epithelial to mesenchymal transition (GO:0010718)3.20614105
81peripheral nervous system neuron development (GO:0048935)3.19785864
82basement membrane organization (GO:0071711)3.19677235
83embryonic skeletal system development (GO:0048706)3.19660803
84midgut development (GO:0007494)3.17875475
85glomerular basement membrane development (GO:0032836)3.16697554
86prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.16366431
87cellular response to vitamin (GO:0071295)3.15787897
88positive regulation of smoothened signaling pathway (GO:0045880)3.10177939
89mesenchyme development (GO:0060485)3.09375503
90branching involved in prostate gland morphogenesis (GO:0060442)3.08150308
91regulation of chondrocyte differentiation (GO:0032330)3.05986350
92axis elongation (GO:0003401)3.05853792
93regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.04494733
94* regulation of heart morphogenesis (GO:2000826)3.04056421
95* hindlimb morphogenesis (GO:0035137)3.02857257
96* embryonic hindlimb morphogenesis (GO:0035116)3.02848256
97negative regulation of BMP signaling pathway (GO:0030514)3.01598137
98lung-associated mesenchyme development (GO:0060484)2.99897979
99insulin-like growth factor receptor signaling pathway (GO:0048009)2.99631252
100embryonic body morphogenesis (GO:0010172)2.99241335
101regulation of gastrulation (GO:0010470)2.98545821
102smooth muscle tissue development (GO:0048745)2.98444803
103bone morphogenesis (GO:0060349)2.98206447
104heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.97819090
105positive regulation of cartilage development (GO:0061036)2.97776805
106glial cell migration (GO:0008347)2.95981205
107extracellular regulation of signal transduction (GO:1900115)2.95457627
108extracellular negative regulation of signal transduction (GO:1900116)2.95457627
109mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.95231505
110muscle cell fate commitment (GO:0042693)2.95071114
111* embryonic appendage morphogenesis (GO:0035113)2.94912697
112* embryonic limb morphogenesis (GO:0030326)2.94912697
113* embryonic skeletal system morphogenesis (GO:0048704)2.94675031
114heterochromatin organization (GO:0070828)2.93866349
115* forelimb morphogenesis (GO:0035136)2.93478680
116blood vessel maturation (GO:0001955)2.92224907
117negative chemotaxis (GO:0050919)2.91739418
118lymphangiogenesis (GO:0001946)2.91716589
119glomerular filtration (GO:0003094)2.91514897
120positive regulation of gastrulation (GO:2000543)2.91430064
121regulation of catenin import into nucleus (GO:0035412)2.90848635
122* appendage morphogenesis (GO:0035107)2.90306158
123* limb morphogenesis (GO:0035108)2.90306158
124epithelial to mesenchymal transition (GO:0001837)2.89868125
125establishment of tissue polarity (GO:0007164)2.89468984
126establishment of planar polarity (GO:0001736)2.89468984
127endothelial cell morphogenesis (GO:0001886)2.89103592
128dermatan sulfate biosynthetic process (GO:0030208)2.88619203
129regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.88366452
130extracellular matrix disassembly (GO:0022617)2.88271591
131endocardial cushion development (GO:0003197)2.88189923
132extracellular fibril organization (GO:0043206)2.87532554
133sympathetic nervous system development (GO:0048485)2.86490612
134organ induction (GO:0001759)2.86103696
135positive regulation of endothelial cell apoptotic process (GO:2000353)2.85869018
136positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84307499
137regulation of axon guidance (GO:1902667)2.83720850
138regulation of axon extension involved in axon guidance (GO:0048841)2.83314258
139blood vessel morphogenesis (GO:0048514)2.82763357
140lymph vessel development (GO:0001945)2.82252923
141cranial nerve morphogenesis (GO:0021602)2.80359239
142type B pancreatic cell proliferation (GO:0044342)2.80113672
143protein localization to cell surface (GO:0034394)2.79714052
144fibril organization (GO:0097435)2.77608653
145negative regulation of smooth muscle cell migration (GO:0014912)2.76810061
146adhesion of symbiont to host cell (GO:0044650)2.76136240
147virion attachment to host cell (GO:0019062)2.76136240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.09730931
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.23560479
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.80785365
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59057499
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31877454
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.06201597
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89520096
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.82448884
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.74664279
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72537135
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.66627066
12* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.66281139
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.64713306
14CLOCK_20551151_ChIP-Seq_293T_Human2.58588766
15* TP63_19390658_ChIP-ChIP_HaCaT_Human2.53745000
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.42592694
17* TP53_20018659_ChIP-ChIP_R1E_Mouse2.37929158
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.31526886
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.30545144
20* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.25398341
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16014184
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.14527091
23E2F7_22180533_ChIP-Seq_HELA_Human2.07328222
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04672812
25BRD4_25478319_ChIP-Seq_HGPS_Human2.04082546
26* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03876096
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03474487
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00422171
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96006665
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87504920
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.85746049
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84492159
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81572614
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.79124481
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78453642
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76800843
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76800843
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75977345
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74836957
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.72256766
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70937851
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.69847208
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65257062
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62326076
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60359051
46* EZH2_27304074_Chip-Seq_ESCs_Mouse1.60046438
47AR_21909140_ChIP-Seq_LNCAP_Human1.55779715
48SMC3_22415368_ChIP-Seq_MEFs_Mouse1.55700063
49* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50728056
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49385908
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.48968207
52MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.48435404
53CJUN_26792858_Chip-Seq_BT549_Human1.48262796
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44493928
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44435337
56* RING1B_27294783_Chip-Seq_NPCs_Mouse1.41261913
57* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.38662624
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.38473464
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36656498
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36508720
61* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36446219
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35186309
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33345578
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33345578
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33345578
66TP53_16413492_ChIP-PET_HCT116_Human1.29944302
67* EZH2_27294783_Chip-Seq_ESCs_Mouse1.29796720
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.27507210
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26564281
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24497459
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21092468
72* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20035505
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18937063
74* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18825177
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18589799
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18331239
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17770609
78TP53_23651856_ChIP-Seq_MEFs_Mouse1.17267577
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16742148
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16330350
81* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15873860
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.15794769
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15144080
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15068329
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14721259
86TP53_18474530_ChIP-ChIP_U2OS_Human1.13394759
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13157794
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12214145
89* RNF2_27304074_Chip-Seq_ESCs_Mouse1.12199868
90TP53_22127205_ChIP-Seq_IMR90_Human1.12073799
91SA1_22415368_ChIP-Seq_MEFs_Mouse1.11662944
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11178038
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11015177
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11015177
95* CBX2_27304074_Chip-Seq_ESCs_Mouse1.10716195
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10306579
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10062731
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09783633
99ATF3_27146783_Chip-Seq_COLON_Human1.08981888
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08299857
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06748284
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.05470836
103KDM2B_26808549_Chip-Seq_DND41_Human1.04381918
104* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04324136
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03332969
106* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03109726
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02753905
108* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02503758
109* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02503758
110* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02495443
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02012314
112* RING1B_27294783_Chip-Seq_ESCs_Mouse1.00960418
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99911019
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99637726
115* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97493309
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97195890
117KDM2B_26808549_Chip-Seq_K562_Human0.97091205
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.95292008
119RACK7_27058665_Chip-Seq_MCF-7_Human0.94857066
120NFI_21473784_ChIP-Seq_ESCs_Mouse0.94668897
121* ERG_21242973_ChIP-ChIP_JURKAT_Human0.94640640
122CHD1_26751641_Chip-Seq_LNCaP_Human0.94085665
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93998411
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93656439
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92254102
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91796805
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91370687
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89299386
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.88485054
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84638383
131TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84181525
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84074915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.85581189
2MP0005503_abnormal_tendon_morphology4.26791662
3MP0009053_abnormal_anal_canal3.80500137
4MP0010030_abnormal_orbit_morphology3.65352979
5MP0003705_abnormal_hypodermis_morpholog3.56388265
6MP0005275_abnormal_skin_tensile3.50726720
7MP0003385_abnormal_body_wall2.99619450
8MP0005623_abnormal_meninges_morphology2.71513484
9* MP0009250_abnormal_appendicular_skeleto2.64791667
10MP0003122_maternal_imprinting2.63058740
11MP0004272_abnormal_basement_membrane2.37556951
12MP0000537_abnormal_urethra_morphology2.20415105
13MP0006054_spinal_hemorrhage2.20128169
14MP0000049_abnormal_middle_ear2.18156570
15MP0003279_aneurysm2.17492795
16MP0003942_abnormal_urinary_system2.15444816
17MP0003123_paternal_imprinting2.13046350
18MP0005508_abnormal_skeleton_morphology2.11749474
19MP0005257_abnormal_intraocular_pressure2.08760613
20MP0002932_abnormal_joint_morphology2.01302733
21MP0003937_abnormal_limbs/digits/tail_de1.97435586
22MP0000428_abnormal_craniofacial_morphol1.91937755
23MP0003950_abnormal_plasma_membrane1.87170910
24MP0002249_abnormal_larynx_morphology1.81168017
25MP0000534_abnormal_ureter_morphology1.78159774
26MP0002282_abnormal_trachea_morphology1.76975605
27MP0001958_emphysema1.74421586
28* MP0003755_abnormal_palate_morphology1.72373706
29MP0009384_cardiac_valve_regurgitation1.70351417
30* MP0000733_abnormal_muscle_development1.62848787
31MP0001299_abnormal_eye_distance/1.55354882
32MP0005076_abnormal_cell_differentiation1.51300929
33MP0003935_abnormal_craniofacial_develop1.49722839
34MP0000516_abnormal_urinary_system1.49698308
35MP0005367_renal/urinary_system_phenotyp1.49698308
36* MP0002115_abnormal_skeleton_extremities1.44828097
37MP0000163_abnormal_cartilage_morphology1.44138964
38MP0002060_abnormal_skin_morphology1.43968172
39MP0002233_abnormal_nose_morphology1.43525952
40MP0003941_abnormal_skin_development1.43341875
41MP0003115_abnormal_respiratory_system1.42108357
42MP0003121_genomic_imprinting1.40634095
43* MP0002116_abnormal_craniofacial_bone1.40518056
44MP0002938_white_spotting1.40054724
45MP0000762_abnormal_tongue_morphology1.39872518
46MP0002896_abnormal_bone_mineralization1.37737615
47* MP0002109_abnormal_limb_morphology1.37661986
48MP0001243_abnormal_dermal_layer1.37194230
49MP0000432_abnormal_head_morphology1.35616256
50MP0010352_gastrointestinal_tract_polyps1.34904700
51MP0010368_abnormal_lymphatic_system1.33400152
52MP0005187_abnormal_penis_morphology1.30107085
53MP0002009_preneoplasia1.29356841
54MP0002108_abnormal_muscle_morphology1.27477532
55MP0002751_abnormal_autonomic_nervous1.26804637
56MP0002111_abnormal_tail_morphology1.25757260
57* MP0002113_abnormal_skeleton_development1.20019825
58MP0003283_abnormal_digestive_organ1.18483501
59MP0005023_abnormal_wound_healing1.17721723
60MP0000767_abnormal_smooth_muscle1.16554473
61MP0002177_abnormal_outer_ear1.16485514
62MP0004858_abnormal_nervous_system1.16322286
63* MP0002114_abnormal_axial_skeleton1.15880490
64MP0009379_abnormal_foot_pigmentation1.15386006
65MP0009780_abnormal_chondrocyte_physiolo1.13227230
66MP0005595_abnormal_vascular_smooth1.11976027
67MP0000751_myopathy1.10947958
68MP0005248_abnormal_Harderian_gland1.10187374
69MP0000538_abnormal_urinary_bladder1.09713883
70MP0000013_abnormal_adipose_tissue1.08225136
71MP0004197_abnormal_fetal_growth/weight/1.07619518
72MP0003091_abnormal_cell_migration1.07539583
73MP0003566_abnormal_cell_adhesion1.07213443
74MP0001293_anophthalmia1.04520566
75MP0004134_abnormal_chest_morphology1.04447069
76MP0001340_abnormal_eyelid_morphology1.04255317
77MP0010386_abnormal_urinary_bladder1.03144883
78MP0001849_ear_inflammation0.98426591
79* MP0000759_abnormal_skeletal_muscle0.98274848
80MP0002092_abnormal_eye_morphology0.96732218
81MP0002295_abnormal_pulmonary_circulatio0.96040631
82MP0003567_abnormal_fetal_cardiomyocyte0.94790224
83* MP0002085_abnormal_embryonic_tissue0.92559104
84MP0000566_synostosis0.91804539
85MP0005390_skeleton_phenotype0.91303406
86MP0005171_absent_coat_pigmentation0.90186253
87MP0004233_abnormal_muscle_weight0.88075798
88MP0002084_abnormal_developmental_patter0.88044568
89MP0003119_abnormal_digestive_system0.87680966
90MP0001348_abnormal_lacrimal_gland0.87362517
91MP0005193_abnormal_anterior_eye0.86055871
92MP0002925_abnormal_cardiovascular_devel0.84413730
93MP0009703_decreased_birth_body0.83923500
94MP0001879_abnormal_lymphatic_vessel0.83724362
95MP0002697_abnormal_eye_size0.82347070
96MP0000749_muscle_degeneration0.82149216
97MP0003938_abnormal_ear_development0.80457924
98MP0005670_abnormal_white_adipose0.78586028
99MP0001286_abnormal_eye_development0.75925482
100MP0001175_abnormal_lung_morphology0.75707599
101MP0002089_abnormal_postnatal_growth/wei0.75142497
102MP0002160_abnormal_reproductive_system0.74661044
103MP0001542_abnormal_bone_strength0.74341596
104MP0000681_abnormal_thyroid_gland0.74128542
105MP0003315_abnormal_perineum_morphology0.74108059
106MP0001614_abnormal_blood_vessel0.70872419
107MP0001270_distended_abdomen0.68447901
108MP0000750_abnormal_muscle_regeneration0.67744202
109MP0005369_muscle_phenotype0.67623592
110MP0006138_congestive_heart_failure0.67112932
111MP0002127_abnormal_cardiovascular_syste0.67067137
112MP0003448_altered_tumor_morphology0.66754585
113MP0009672_abnormal_birth_weight0.66529023
114MP0001915_intracranial_hemorrhage0.66502828
115MP0002102_abnormal_ear_morphology0.65773299
116MP0000462_abnormal_digestive_system0.65731865
117MP0001697_abnormal_embryo_size0.65447643
118* MP0002128_abnormal_blood_circulation0.65296136
119MP0008007_abnormal_cellular_replicative0.64460932
120MP0002877_abnormal_melanocyte_morpholog0.64113398
121MP0008932_abnormal_embryonic_tissue0.63865960
122MP0000003_abnormal_adipose_tissue0.63556388
123MP0001672_abnormal_embryogenesis/_devel0.63417579
124MP0005380_embryogenesis_phenotype0.63417579
125MP0005197_abnormal_uvea_morphology0.62927628
126MP0001661_extended_life_span0.59805349
127MP0002638_abnormal_pupillary_reflex0.58724518
128MP0001346_abnormal_lacrimal_gland0.55779897
129MP0002933_joint_inflammation0.53751313
130MP0005409_darkened_coat_color0.53172191
131MP0005375_adipose_tissue_phenotype0.52711921

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.55741911
2Premature rupture of membranes (HP:0001788)6.18855873
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.55684214
4Short 4th metacarpal (HP:0010044)4.55684214
5Abnormality of the 4th metacarpal (HP:0010012)4.20410689
6* Shallow orbits (HP:0000586)4.17930079
7Ankle contracture (HP:0006466)3.92234071
8Soft skin (HP:0000977)3.73747611
9Aortic dissection (HP:0002647)3.66709571
10Atrophic scars (HP:0001075)3.58773181
11Broad metatarsal (HP:0001783)3.55354246
12Bladder diverticulum (HP:0000015)3.48858527
13Renal duplication (HP:0000075)3.45324065
14Short middle phalanx of the 5th finger (HP:0004220)3.36086062
15Peritonitis (HP:0002586)3.30739619
16Abnormality of dentin (HP:0010299)3.30073456
17Mesomelia (HP:0003027)3.27677127
18Fragile skin (HP:0001030)3.14019900
19Mitral valve prolapse (HP:0001634)3.12829454
20Neonatal short-limb short stature (HP:0008921)3.11434927
21Arterial tortuosity (HP:0005116)3.05107020
22Cerebral aneurysm (HP:0004944)3.04829004
23Hypoventilation (HP:0002791)3.01261265
24Dilatation of the ascending aorta (HP:0005111)2.97122931
25Spondylolisthesis (HP:0003302)2.96853330
26Genu recurvatum (HP:0002816)2.95611664
27Follicular hyperkeratosis (HP:0007502)2.86046664
28* Deviation of the hallux (HP:0010051)2.85659840
29Blue sclerae (HP:0000592)2.85039439
30Spinal cord lesions (HP:0100561)2.77851332
31Syringomyelia (HP:0003396)2.77851332
32Wide anterior fontanel (HP:0000260)2.75122219
33Short 5th finger (HP:0009237)2.71735177
34Cervical subluxation (HP:0003308)2.71372035
35Microglossia (HP:0000171)2.69749243
36Biconcave vertebral bodies (HP:0004586)2.65272558
37* Hallux valgus (HP:0001822)2.60526899
38Type 1 muscle fiber predominance (HP:0003803)2.58694375
39Wormian bones (HP:0002645)2.47316117
40Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.46526016
41Broad long bones (HP:0005622)2.45532958
42Bowel diverticulosis (HP:0005222)2.42622494
43Wrist flexion contracture (HP:0001239)2.40280636
44Aortic aneurysm (HP:0004942)2.37567209
45Mild short stature (HP:0003502)2.37240003
46Broad thumb (HP:0011304)2.37207949
47Asymmetry of the thorax (HP:0001555)2.34324619
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.33361983
49Spinal rigidity (HP:0003306)2.32707834
50Increased variability in muscle fiber diameter (HP:0003557)2.30665834
51Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.30298124
52Absent frontal sinuses (HP:0002688)2.29601682
53Vertebral compression fractures (HP:0002953)2.29178716
54Slender build (HP:0001533)2.26492444
55Long toe (HP:0010511)2.25356965
56Osteolytic defects of the hand bones (HP:0009699)2.23947948
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.23947948
58Joint laxity (HP:0001388)2.19313610
59Hyperextensible skin (HP:0000974)2.19296663
60Aortic regurgitation (HP:0001659)2.19155651
61* Broad toe (HP:0001837)2.19046974
62Aplasia of the musculature (HP:0100854)2.18098997
63Broad phalanx (HP:0006009)2.14476311
64Elbow flexion contracture (HP:0002987)2.14227258
65Mitral regurgitation (HP:0001653)2.11615257
66Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.10754906
67* Delayed cranial suture closure (HP:0000270)2.10304253
68Sparse lateral eyebrow (HP:0005338)2.08896928
69Broad phalanges of the hand (HP:0009768)2.06828407
70Ectopia lentis (HP:0001083)2.05977016
71Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.04425395
72Broad finger (HP:0001500)2.03786677
73Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03477507
74Morphological abnormality of the middle ear (HP:0008609)2.03120851
75Cutaneous finger syndactyly (HP:0010554)2.02313535
76Increased connective tissue (HP:0009025)2.01862045
77Camptodactyly of toe (HP:0001836)2.01045170
78Ulnar bowing (HP:0003031)2.00513300
79Abnormal delivery (HP:0001787)2.00489773
80Infantile muscular hypotonia (HP:0008947)1.98884728
81Selective tooth agenesis (HP:0001592)1.98192494
82Overgrowth (HP:0001548)1.97618946
83* Abnormality of the parietal bone (HP:0002696)1.97012047
84Hepatoblastoma (HP:0002884)1.95765133
85Abnormality of the fetal cardiovascular system (HP:0010948)1.95168717
86Abnormal umbilical cord blood vessels (HP:0011403)1.95168717
87Single umbilical artery (HP:0001195)1.95168717
88Bell-shaped thorax (HP:0001591)1.94620548
89Lymphangioma (HP:0100764)1.94583412
90Nonimmune hydrops fetalis (HP:0001790)1.94013941
91Abnormality of the peritoneum (HP:0002585)1.92475918
92Abnormality of the phalanges of the 5th finger (HP:0004213)1.89522118
93Hypoplasia of the iris (HP:0007676)1.89494855
94Abnormality of the distal phalanges of the toes (HP:0010182)1.89492806
95Abnormality of skull ossification (HP:0002703)1.88770517
96* Abnormality of the phalanges of the hallux (HP:0010057)1.88437298
97Mildly elevated creatine phosphokinase (HP:0008180)1.88265686
98Aortic valve stenosis (HP:0001650)1.88122801
99Renovascular hypertension (HP:0100817)1.88059857
100Osteoarthritis (HP:0002758)1.87094396
101Cupped ribs (HP:0000887)1.86229012
102* Coronal craniosynostosis (HP:0004440)1.84418979
103Short clavicles (HP:0000894)1.84389128
104Disproportionate tall stature (HP:0001519)1.84199939
105Venous insufficiency (HP:0005293)1.84128759
106Delayed closure of the anterior fontanelle (HP:0001476)1.84011039
107Deformed tarsal bones (HP:0008119)1.83811523
108Flat cornea (HP:0007720)1.82288881
109Calcaneovalgus deformity (HP:0001848)1.82213630
110Bowed forearm bones (HP:0003956)1.81549712
111Bowing of the arm (HP:0006488)1.81549712
112Short phalanx of the thumb (HP:0009660)1.80982787
113Decreased skull ossification (HP:0004331)1.80966883
114Protruding ear (HP:0000411)1.80433712
115Chin dimple (HP:0010751)1.79873260
116Midline defect of the nose (HP:0004122)1.79548058
117Generalized amyotrophy (HP:0003700)1.79494621
118Joint stiffness (HP:0001387)1.78743379
119Abnormality of the acetabulum (HP:0003170)1.78408990
120Abnormality of skeletal muscle fiber size (HP:0012084)1.77896988
121Reduced subcutaneous adipose tissue (HP:0003758)1.77129707
122Abnormality of the frontal sinuses (HP:0002687)1.76526361
123Venous abnormality (HP:0002624)1.75784418
124Preaxial foot polydactyly (HP:0001841)1.75270014
125Abnormality of the middle phalanges of the toes (HP:0010183)1.75172612
126Broad ribs (HP:0000885)1.75079695
127Increased corneal curvature (HP:0100692)1.74958102
128Short middle phalanx of finger (HP:0005819)1.74885793
129Inguinal hernia (HP:0000023)1.74829014
130Knee flexion contracture (HP:0006380)1.73955318
131Cutaneous syndactyly (HP:0012725)1.72417921
132Carpal synostosis (HP:0009702)1.72322365
133Vascular tortuosity (HP:0004948)1.72209577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.65478627
2MYLK3.74824947
3PDGFRA3.73257262
4LATS13.73200372
5TRIB33.70975821
6LATS23.68464418
7EPHB23.32765986
8AKT33.22886178
9NTRK12.80224689
10PKN22.45373814
11TTN2.45362895
12MAP3K102.43564231
13MKNK12.07142464
14PAK22.04805413
15SIK11.89706163
16RIPK11.86891909
17EPHA31.82660106
18BMX1.75054121
19PAK41.65450476
20FGFR11.65117231
21STK31.62962806
22ABL21.59492544
23PTK61.59328979
24CDK121.51363779
25FER1.45647163
26FGFR21.43097947
27BUB11.38811956
28ERN11.36410708
29PTK21.36285639
30MKNK21.34930320
31SCYL21.30250246
32MTOR1.29788135
33INSRR1.28231060
34PRKD31.27309291
35RPS6KA41.26002406
36NEK91.24949494
37CDC71.21759218
38STK38L1.18998826
39PDGFRB1.15777730
40TGFBR11.14960049
41CDK61.12239672
42EEF2K1.12223404
43CDK81.10166891
44PNCK1.07369547
45LRRK21.06287656
46TLK11.06244913
47MET1.05550093
48DMPK1.05409428
49KIT1.01306696
50GSK3A1.00784180
51ILK1.00178561
52ICK0.94060538
53TAF10.94014057
54ERBB30.91348468
55STK380.88822754
56PTK2B0.88758856
57WNK10.86278849
58MAPK70.86143864
59NEK20.83848187
60TGFBR20.83072314
61CAMK1D0.82083929
62MOS0.81754321
63SMG10.75968643
64RPS6KA20.75683884
65CDK70.75445198
66ROCK10.75254590
67MAP3K80.74598578
68RPS6KC10.74327141
69RPS6KL10.74327141
70ERBB40.74186873
71GRK70.72962426
72PRKD20.72772776
73PLK40.70806170
74CAMK1G0.69923573
75DYRK1B0.69842413
76ERBB20.68525639
77MAP3K60.68275658
78AKT20.67725426
79PIK3CG0.67514137
80LIMK10.63885150
81GRK50.63220930
82RPS6KA60.63150908
83WEE10.60526455
84PAK30.60400380
85BRSK10.59678981
86PLK30.59450202
87TESK10.58104105
88TTK0.56906989
89ALK0.56511170
90MUSK0.55060075
91DAPK30.53855297
92MAP3K30.51782812
93PAK10.51679948
94ROCK20.51463258
95MAP2K10.50795161
96PAK60.49993529
97PASK0.49673897
98VRK20.49390473
99INSR0.48906848
100MELK0.48354556
101MAP2K30.48240848
102NME20.48168873
103AURKA0.48074283
104CLK10.47486730
105TYRO30.47368680
106CDK90.47168564
107TAOK20.47017188
108PLK10.46056297
109ADRBK10.45494286
110STK40.45364243
111FGFR30.45240880
112ADRBK20.44382517
113PRKD10.41884181
114CDK40.41583245
115BRD40.41546906
116* MAPK10.41436666
117PLK20.41330054
118CAMK2G0.39422730
119TESK20.38973366
120FLT30.38776822
121PRKCH0.36448241
122SRC0.36083222
123AURKB0.35687575
124CDK140.35559435
125TRPM70.35062490
126CDK20.34484157
127MAPK40.34103118
128FRK0.33340266
129ATM0.33167735
130CHEK20.32788998
131PIK3CA0.32247373
132PKN10.32139078
133PRKCE0.32130920
134RET0.31864550
135CSNK1A1L0.31856516
136CDC42BPA0.31284662
137NEK10.30818234
138CDK10.29837156
139DYRK30.29620795
140STK160.29297427
141BRSK20.27273031

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.20692708
2Hedgehog signaling pathway_Homo sapiens_hsa043403.46048413
3ECM-receptor interaction_Homo sapiens_hsa045123.31685818
4Hippo signaling pathway_Homo sapiens_hsa043902.94954848
5* Proteoglycans in cancer_Homo sapiens_hsa052052.53078854
6Focal adhesion_Homo sapiens_hsa045102.49585158
7TGF-beta signaling pathway_Homo sapiens_hsa043502.48978829
8Protein digestion and absorption_Homo sapiens_hsa049742.19096549
9Adherens junction_Homo sapiens_hsa045202.18876935
10MicroRNAs in cancer_Homo sapiens_hsa052062.17314002
11Wnt signaling pathway_Homo sapiens_hsa043102.13422197
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.09542198
13Bladder cancer_Homo sapiens_hsa052191.99706319
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87120555
15Chronic myeloid leukemia_Homo sapiens_hsa052201.85058537
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.83571194
17Cell cycle_Homo sapiens_hsa041101.83187955
18Small cell lung cancer_Homo sapiens_hsa052221.77312885
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71400801
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.71110142
21Sulfur relay system_Homo sapiens_hsa041221.58962580
22Amoebiasis_Homo sapiens_hsa051461.57610646
23HTLV-I infection_Homo sapiens_hsa051661.56886473
24Melanoma_Homo sapiens_hsa052181.56477638
25Melanogenesis_Homo sapiens_hsa049161.54269542
26Pathways in cancer_Homo sapiens_hsa052001.54143183
27p53 signaling pathway_Homo sapiens_hsa041151.51802830
28Axon guidance_Homo sapiens_hsa043601.51164008
29Prostate cancer_Homo sapiens_hsa052151.47310221
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44346028
31Colorectal cancer_Homo sapiens_hsa052101.43107186
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33788258
33Glioma_Homo sapiens_hsa052141.31039982
34Thyroid cancer_Homo sapiens_hsa052161.26079388
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23556842
36Spliceosome_Homo sapiens_hsa030401.18436172
37Dilated cardiomyopathy_Homo sapiens_hsa054141.15396490
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13912198
39Endometrial cancer_Homo sapiens_hsa052131.11025161
40RNA transport_Homo sapiens_hsa030131.10746288
41Viral myocarditis_Homo sapiens_hsa054161.10131386
42Malaria_Homo sapiens_hsa051441.09721265
43Notch signaling pathway_Homo sapiens_hsa043301.07838397
44Pancreatic cancer_Homo sapiens_hsa052121.07800628
45Sulfur metabolism_Homo sapiens_hsa009201.05895312
46Tight junction_Homo sapiens_hsa045301.04138418
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02944237
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.00982912
49Rap1 signaling pathway_Homo sapiens_hsa040151.00097180
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.98784437
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98716801
52Viral carcinogenesis_Homo sapiens_hsa052030.96574977
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93531176
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90589172
55mRNA surveillance pathway_Homo sapiens_hsa030150.90534928
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89928519
57mTOR signaling pathway_Homo sapiens_hsa041500.87471747
58Lysine degradation_Homo sapiens_hsa003100.87001586
59Ribosome_Homo sapiens_hsa030100.86983506
60Renin-angiotensin system_Homo sapiens_hsa046140.85795895
61Renal cell carcinoma_Homo sapiens_hsa052110.84035906
62Cocaine addiction_Homo sapiens_hsa050300.79291274
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77754513
64Non-small cell lung cancer_Homo sapiens_hsa052230.77639338
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76142641
66Folate biosynthesis_Homo sapiens_hsa007900.75814700
67Gap junction_Homo sapiens_hsa045400.73740509
68Estrogen signaling pathway_Homo sapiens_hsa049150.73434330
69Hepatitis B_Homo sapiens_hsa051610.72214785
70Oocyte meiosis_Homo sapiens_hsa041140.70182287
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.69252287
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69155180
73One carbon pool by folate_Homo sapiens_hsa006700.69078213
74Platelet activation_Homo sapiens_hsa046110.68243813
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.68172618
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66265982
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65116557
78Systemic lupus erythematosus_Homo sapiens_hsa053220.63389616
79Shigellosis_Homo sapiens_hsa051310.61767786
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60204453
81Renin secretion_Homo sapiens_hsa049240.60061499
82Basal transcription factors_Homo sapiens_hsa030220.58714864
83FoxO signaling pathway_Homo sapiens_hsa040680.58667523
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58553264
85Cholinergic synapse_Homo sapiens_hsa047250.58273229
86HIF-1 signaling pathway_Homo sapiens_hsa040660.57400922
87Calcium signaling pathway_Homo sapiens_hsa040200.57306856
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56478225
89Prion diseases_Homo sapiens_hsa050200.54021045
90AMPK signaling pathway_Homo sapiens_hsa041520.53042665
91TNF signaling pathway_Homo sapiens_hsa046680.52520801
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52156625
93cAMP signaling pathway_Homo sapiens_hsa040240.50397616
94Toxoplasmosis_Homo sapiens_hsa051450.48374462
95PPAR signaling pathway_Homo sapiens_hsa033200.48113413
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47976724
97ErbB signaling pathway_Homo sapiens_hsa040120.46524586
98MAPK signaling pathway_Homo sapiens_hsa040100.46281720
99Protein export_Homo sapiens_hsa030600.45915017
100VEGF signaling pathway_Homo sapiens_hsa043700.44607312
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43009716
102Ras signaling pathway_Homo sapiens_hsa040140.42551590
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42128876
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.41779518
105Endocytosis_Homo sapiens_hsa041440.41696117
106Acute myeloid leukemia_Homo sapiens_hsa052210.41580356
107Pyruvate metabolism_Homo sapiens_hsa006200.41186792
108Insulin signaling pathway_Homo sapiens_hsa049100.40289469
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.40073750
110Alcoholism_Homo sapiens_hsa050340.40047672
111Vibrio cholerae infection_Homo sapiens_hsa051100.39862159
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37924213
113Insulin resistance_Homo sapiens_hsa049310.37582436
114DNA replication_Homo sapiens_hsa030300.37044117
115GnRH signaling pathway_Homo sapiens_hsa049120.36985079
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36958174
117Glutathione metabolism_Homo sapiens_hsa004800.34225254
118Apoptosis_Homo sapiens_hsa042100.33969930
119Epstein-Barr virus infection_Homo sapiens_hsa051690.32876382
120Thyroid hormone synthesis_Homo sapiens_hsa049180.32036877
121N-Glycan biosynthesis_Homo sapiens_hsa005100.31440372
122Nucleotide excision repair_Homo sapiens_hsa034200.30086489
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27842836
124Oxytocin signaling pathway_Homo sapiens_hsa049210.26746014
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22121134

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