TVP23C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine ribonucleotide transport (GO:0015868)7.89616134
2nucleotide transmembrane transport (GO:1901679)7.87586794
3adenine nucleotide transport (GO:0051503)7.47575557
4nucleoside transmembrane transport (GO:1901642)6.78858988
5heme transport (GO:0015886)6.41786787
6regulation of phospholipid biosynthetic process (GO:0071071)6.26322783
7regulation of isotype switching to IgG isotypes (GO:0048302)6.24562642
8phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.96521482
9negative regulation of type 2 immune response (GO:0002829)5.90030222
10organic cation transport (GO:0015695)5.89679870
11purine nucleotide transport (GO:0015865)5.85691743
12cofactor transport (GO:0051181)5.71226830
13phosphatidylcholine acyl-chain remodeling (GO:0036151)5.68240067
14negative regulation of telomerase activity (GO:0051974)5.58023095
15surfactant homeostasis (GO:0043129)5.18366676
16chaperone-mediated protein transport (GO:0072321)5.12195742
17folic acid transport (GO:0015884)4.97510635
18telomere maintenance via telomerase (GO:0007004)4.89327283
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.89033869
20iron coordination entity transport (GO:1901678)4.73712907
21positive regulation of T-helper 1 type immune response (GO:0002827)4.72236993
22protein K6-linked ubiquitination (GO:0085020)4.55453107
23nucleoside transport (GO:0015858)4.51371522
24chemical homeostasis within a tissue (GO:0048875)4.46570059
25synapsis (GO:0007129)4.45496516
26folic acid-containing compound biosynthetic process (GO:0009396)4.42453265
27establishment of nucleus localization (GO:0040023)4.34534134
28phosphatidylinositol acyl-chain remodeling (GO:0036149)4.31450053
29ATP synthesis coupled proton transport (GO:0015986)4.02959928
30energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02959928
31negative regulation of multicellular organism growth (GO:0040015)3.99724815
32nucleotide transport (GO:0006862)3.92366576
33positive regulation of translational initiation (GO:0045948)3.92300469
34protein K63-linked deubiquitination (GO:0070536)3.90787724
35regulation of feeding behavior (GO:0060259)3.90326988
36regulation of telomerase activity (GO:0051972)3.88436138
37neuron remodeling (GO:0016322)3.82373919
38protein neddylation (GO:0045116)3.79113493
39DNA deamination (GO:0045006)3.77759425
40glycerophospholipid catabolic process (GO:0046475)3.74139102
41phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.67983990
42polarized epithelial cell differentiation (GO:0030859)3.60711758
43male meiosis I (GO:0007141)3.60049858
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59098565
45regulation of type B pancreatic cell apoptotic process (GO:2000674)3.48325350
46folic acid-containing compound metabolic process (GO:0006760)3.45728155
47folic acid metabolic process (GO:0046655)3.43622133
48regulation of T-helper 1 type immune response (GO:0002825)3.40866226
49kynurenine metabolic process (GO:0070189)3.36229448
50negative regulation of DNA biosynthetic process (GO:2000279)3.33993109
51cellular ketone body metabolic process (GO:0046950)3.24272745
52serine family amino acid biosynthetic process (GO:0009070)3.21726191
53phosphatidylglycerol metabolic process (GO:0046471)3.21426819
54regulation of centriole replication (GO:0046599)3.21013013
55behavioral response to nicotine (GO:0035095)3.14998833
56keratan sulfate biosynthetic process (GO:0018146)3.12256889
57water-soluble vitamin biosynthetic process (GO:0042364)3.10498792
58RNA-dependent DNA replication (GO:0006278)3.10026756
59atrial cardiac muscle cell action potential (GO:0086014)3.06236828
60negative regulation of telomere maintenance (GO:0032205)3.05728228
61pteridine-containing compound biosynthetic process (GO:0042559)3.02805916
62maintenance of protein location in nucleus (GO:0051457)3.02267644
63negative regulation of alcohol biosynthetic process (GO:1902931)2.98354797
64regulation of interferon-beta biosynthetic process (GO:0045357)2.96714493
65inositol phosphate catabolic process (GO:0071545)2.94641171
66ketone body metabolic process (GO:1902224)2.93776402
67disruption of cells of other organism (GO:0044364)2.92456724
68killing of cells of other organism (GO:0031640)2.92456724
69parturition (GO:0007567)2.91074907
70maturation of 5.8S rRNA (GO:0000460)2.90970839
71multicellular organism reproduction (GO:0032504)2.84825110
72glycine metabolic process (GO:0006544)2.84266448
73pteridine-containing compound metabolic process (GO:0042558)2.83401560
74reciprocal DNA recombination (GO:0035825)2.83241393
75reciprocal meiotic recombination (GO:0007131)2.83241393
76collecting duct development (GO:0072044)2.83217346
77regulation of cilium movement (GO:0003352)2.81714760
78phosphatidic acid biosynthetic process (GO:0006654)2.74878408
79phosphatidic acid metabolic process (GO:0046473)2.74878408
80indole-containing compound catabolic process (GO:0042436)2.74624795
81indolalkylamine catabolic process (GO:0046218)2.74624795
82tryptophan catabolic process (GO:0006569)2.74624795
83protein deneddylation (GO:0000338)2.73945244
84regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.73784853
85tetrahydrofolate metabolic process (GO:0046653)2.72025391
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70063874
87phosphorylated carbohydrate dephosphorylation (GO:0046838)2.69131979
88inositol phosphate dephosphorylation (GO:0046855)2.69131979
89negative regulation of mast cell activation (GO:0033004)2.68848578
90phosphatidylserine acyl-chain remodeling (GO:0036150)2.65400876
91meiosis I (GO:0007127)2.63964457
92response to pheromone (GO:0019236)2.62318624
93protein localization to cilium (GO:0061512)2.61588981
94indolalkylamine metabolic process (GO:0006586)2.59948689
95substrate-dependent cell migration (GO:0006929)2.58466985
96positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.55539550
97cytidine catabolic process (GO:0006216)2.52972026
98cytidine deamination (GO:0009972)2.52972026
99cytidine metabolic process (GO:0046087)2.52972026
100exogenous drug catabolic process (GO:0042738)2.52583542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.34704314
2ZNF274_21170338_ChIP-Seq_K562_Hela3.28383513
3VDR_22108803_ChIP-Seq_LS180_Human3.19188497
4GBX2_23144817_ChIP-Seq_PC3_Human2.81086865
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.72579117
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66264563
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49729429
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36432706
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21065884
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19746813
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.19589842
12TAF15_26573619_Chip-Seq_HEK293_Human2.16807245
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15927467
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13169662
15EWS_26573619_Chip-Seq_HEK293_Human2.12462152
16FUS_26573619_Chip-Seq_HEK293_Human2.02648848
17ER_23166858_ChIP-Seq_MCF-7_Human1.94994867
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87946487
19P300_19829295_ChIP-Seq_ESCs_Human1.83428594
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83056041
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81977608
22EZH2_22144423_ChIP-Seq_EOC_Human1.78437158
23TP53_22573176_ChIP-Seq_HFKS_Human1.74409783
24GATA3_21878914_ChIP-Seq_MCF-7_Human1.67614147
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60564683
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58361777
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57335813
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57042321
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.55909172
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55439133
31STAT3_23295773_ChIP-Seq_U87_Human1.54349327
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.52970541
33IGF1R_20145208_ChIP-Seq_DFB_Human1.52246346
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50353540
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.50353540
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.49222716
37TCF4_23295773_ChIP-Seq_U87_Human1.49124350
38CBP_20019798_ChIP-Seq_JUKART_Human1.48606954
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48606954
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47478178
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45634234
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.45485328
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45328640
44SMAD4_21799915_ChIP-Seq_A2780_Human1.44138301
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41043306
46NANOG_19829295_ChIP-Seq_ESCs_Human1.39649867
47SOX2_19829295_ChIP-Seq_ESCs_Human1.39649867
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38233492
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38139305
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.36398715
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.35094496
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.34900281
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34240976
54BCAT_22108803_ChIP-Seq_LS180_Human1.32741696
55VDR_23849224_ChIP-Seq_CD4+_Human1.32024743
56AR_20517297_ChIP-Seq_VCAP_Human1.31587156
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31076522
58TCF4_22108803_ChIP-Seq_LS180_Human1.30447956
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30091232
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.26665329
61NCOR_22424771_ChIP-Seq_293T_Human1.26301964
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26168507
63AR_25329375_ChIP-Seq_VCAP_Human1.25505581
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24574810
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23990127
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.23410754
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22683781
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.22381344
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21357642
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18952444
71TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18228943
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15807685
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14704301
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14508194
75RUNX2_22187159_ChIP-Seq_PCA_Human1.13922452
76GATA3_26560356_Chip-Seq_TH2_Human1.11540521
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10337996
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08438782
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08051406
80AR_21572438_ChIP-Seq_LNCaP_Human1.07286545
81GATA1_22025678_ChIP-Seq_K562_Human1.06774418
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.06700669
83IRF1_19129219_ChIP-ChIP_H3396_Human1.05498614
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05443954
85P53_22387025_ChIP-Seq_ESCs_Mouse1.05382422
86CDX2_22108803_ChIP-Seq_LS180_Human1.05335163
87REST_21632747_ChIP-Seq_MESCs_Mouse1.05219406
88ELK1_19687146_ChIP-ChIP_HELA_Human1.04097632
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03816851
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.02861692
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02753571
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.02398982
93RXR_22108803_ChIP-Seq_LS180_Human1.01992875
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.00474593
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00374466
96RNF2_27304074_Chip-Seq_NSC_Mouse1.00045943
97OCT4_20526341_ChIP-Seq_ESCs_Human0.98632353
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97519267
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.95390692
100HOXB7_26014856_ChIP-Seq_BT474_Human0.95388077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog5.17252152
2MP0003011_delayed_dark_adaptation4.16380367
3MP0002653_abnormal_ependyma_morphology4.03705172
4MP0003195_calcinosis3.21091603
5MP0001177_atelectasis3.17132919
6MP0005551_abnormal_eye_electrophysiolog2.77814317
7MP0008877_abnormal_DNA_methylation2.72978542
8MP0002332_abnormal_exercise_endurance2.36802356
9MP0002837_dystrophic_cardiac_calcinosis2.12963502
10MP0002102_abnormal_ear_morphology2.10629752
11MP0001440_abnormal_grooming_behavior2.08136946
12MP0002736_abnormal_nociception_after2.00577017
13MP0001968_abnormal_touch/_nociception1.98029624
14MP0003137_abnormal_impulse_conducting1.88634536
15MP0008875_abnormal_xenobiotic_pharmacok1.85649657
16MP0005394_taste/olfaction_phenotype1.83664373
17MP0005499_abnormal_olfactory_system1.83664373
18MP0002295_abnormal_pulmonary_circulatio1.75520227
19MP0002876_abnormal_thyroid_physiology1.72420827
20MP0005253_abnormal_eye_physiology1.71530871
21MP0002160_abnormal_reproductive_system1.68818116
22MP0005085_abnormal_gallbladder_physiolo1.65152859
23MP0004142_abnormal_muscle_tone1.60903333
24MP0006072_abnormal_retinal_apoptosis1.56397604
25MP0002938_white_spotting1.55134171
26MP0005389_reproductive_system_phenotype1.54349050
27MP0001986_abnormal_taste_sensitivity1.47003690
28MP0003890_abnormal_embryonic-extraembry1.44081970
29MP0008872_abnormal_physiological_respon1.42416901
30MP0001293_anophthalmia1.37954686
31MP0006292_abnormal_olfactory_placode1.37061246
32MP0009046_muscle_twitch1.36590690
33MP0001873_stomach_inflammation1.36371779
34MP0009745_abnormal_behavioral_response1.36275594
35MP0002638_abnormal_pupillary_reflex1.36115168
36MP0003183_abnormal_peptide_metabolism1.34225079
37MP0000427_abnormal_hair_cycle1.33969630
38MP0000566_synostosis1.32467459
39MP0005645_abnormal_hypothalamus_physiol1.30237994
40MP0000372_irregular_coat_pigmentation1.26178534
41MP0001984_abnormal_olfaction1.25724696
42MP0003787_abnormal_imprinting1.22276286
43MP0000569_abnormal_digit_pigmentation1.20574976
44MP0000462_abnormal_digestive_system1.19485207
45MP0010030_abnormal_orbit_morphology1.16579623
46MP0000383_abnormal_hair_follicle1.14831706
47MP0008789_abnormal_olfactory_epithelium1.14020311
48MP0002133_abnormal_respiratory_system1.12227092
49MP0005388_respiratory_system_phenotype1.12227092
50MP0002272_abnormal_nervous_system1.11691339
51MP0009764_decreased_sensitivity_to1.06323851
52MP0001919_abnormal_reproductive_system1.05888328
53MP0000631_abnormal_neuroendocrine_gland1.05538929
54MP0001485_abnormal_pinna_reflex1.03945739
55MP0003646_muscle_fatigue1.02658906
56MP0001529_abnormal_vocalization1.02049161
57MP0006276_abnormal_autonomic_nervous1.01651747
58MP0010386_abnormal_urinary_bladder1.01251150
59MP0004885_abnormal_endolymph0.99096972
60MP0005266_abnormal_metabolism0.98044393
61MP0004924_abnormal_behavior0.97725337
62MP0005386_behavior/neurological_phenoty0.97725337
63MP0001501_abnormal_sleep_pattern0.96805285
64MP0005646_abnormal_pituitary_gland0.96031871
65MP0002751_abnormal_autonomic_nervous0.95617210
66MP0005332_abnormal_amino_acid0.91536087
67MP0001486_abnormal_startle_reflex0.91250801
68MP0002693_abnormal_pancreas_physiology0.90180326
69MP0001929_abnormal_gametogenesis0.88909851
70MP0002928_abnormal_bile_duct0.87806562
71MP0002557_abnormal_social/conspecific_i0.87804417
72MP0004133_heterotaxia0.87728743
73MP0001851_eye_inflammation0.86759081
74MP0002572_abnormal_emotion/affect_behav0.86717347
75MP0004085_abnormal_heartbeat0.86661192
76MP0000538_abnormal_urinary_bladder0.85396264
77MP0001502_abnormal_circadian_rhythm0.85176892
78MP0003880_abnormal_central_pattern0.85170476
79MP0005084_abnormal_gallbladder_morpholo0.85079342
80MP0003959_abnormal_lean_body0.83036949
81MP0001905_abnormal_dopamine_level0.81210515
82MP0003698_abnormal_male_reproductive0.81205574
83MP0002163_abnormal_gland_morphology0.80269617
84MP0005379_endocrine/exocrine_gland_phen0.78525242
85MP0004145_abnormal_muscle_electrophysio0.78471497
86MP0001944_abnormal_pancreas_morphology0.78114066
87MP0000647_abnormal_sebaceous_gland0.76997940
88MP0002210_abnormal_sex_determination0.75712279
89MP0002064_seizures0.75419196
90MP0005365_abnormal_bile_salt0.75070414
91MP0005220_abnormal_exocrine_pancreas0.74923789
92MP0005448_abnormal_energy_balance0.74600965
93MP0005391_vision/eye_phenotype0.74452796
94MP0006036_abnormal_mitochondrial_physio0.74156632
95MP0005195_abnormal_posterior_eye0.73271329
96MP0002735_abnormal_chemical_nociception0.72037116
97MP0002752_abnormal_somatic_nervous0.71858424
98MP0002095_abnormal_skin_pigmentation0.71324701
99MP0001119_abnormal_female_reproductive0.71222990
100MP0002069_abnormal_eating/drinking_beha0.69268715

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.20112876
2Abnormality of midbrain morphology (HP:0002418)4.00298757
3Molar tooth sign on MRI (HP:0002419)4.00298757
4Cheilitis (HP:0100825)3.65268950
5Pancreatic cysts (HP:0001737)3.51338572
6Stomach cancer (HP:0012126)3.46557455
7Congenital stationary night blindness (HP:0007642)3.45924943
8Large for gestational age (HP:0001520)3.33690511
9Pancreatic fibrosis (HP:0100732)3.32667551
10Abnormality of eosinophils (HP:0001879)3.28088417
11True hermaphroditism (HP:0010459)3.27032354
12Abnormality of the renal cortex (HP:0011035)3.14327294
13Megaloblastic anemia (HP:0001889)3.02439552
14Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.87904424
15Short 1st metacarpal (HP:0010034)2.87904424
16Abnormality of the labia minora (HP:0012880)2.87545140
17Abnormality of macular pigmentation (HP:0008002)2.86030143
18Dyskinesia (HP:0100660)2.84180197
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.79941784
20Absent/shortened dynein arms (HP:0200106)2.79941784
21Nephronophthisis (HP:0000090)2.72162625
22Medial flaring of the eyebrow (HP:0010747)2.71275752
23Renal cortical cysts (HP:0000803)2.69862751
24Conical tooth (HP:0000698)2.55300220
25Congenital, generalized hypertrichosis (HP:0004540)2.54334668
26Abolished electroretinogram (ERG) (HP:0000550)2.52462806
27Abnormality of the 1st metacarpal (HP:0010009)2.52348358
28Basal ganglia calcification (HP:0002135)2.48239103
29Abnormal drinking behavior (HP:0030082)2.45463858
30Polydipsia (HP:0001959)2.45463858
31Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45388860
32Sclerocornea (HP:0000647)2.38622715
33Cystic liver disease (HP:0006706)2.36271225
34Abnormality of the renal medulla (HP:0100957)2.33282530
35Progressive cerebellar ataxia (HP:0002073)2.32195817
36Rib fusion (HP:0000902)2.31050400
37Tubular atrophy (HP:0000092)2.26967038
38Increased hepatocellular lipid droplets (HP:0006565)2.25738633
39Proximal amyotrophy (HP:0007126)2.20863926
40Abnormal biliary tract physiology (HP:0012439)2.20351953
41Bile duct proliferation (HP:0001408)2.20351953
42Lipid accumulation in hepatocytes (HP:0006561)2.17649580
43Congenital primary aphakia (HP:0007707)2.16732919
44Gait imbalance (HP:0002141)2.15828252
45Decreased circulating renin level (HP:0003351)2.15001442
46IgG deficiency (HP:0004315)2.11481974
47Retinal dysplasia (HP:0007973)2.10314411
48Genital tract atresia (HP:0001827)2.10042842
49Vaginal atresia (HP:0000148)2.08744820
50Hypothermia (HP:0002045)2.08519999
51Abnormal respiratory epithelium morphology (HP:0012253)2.07541782
52Abnormal respiratory motile cilium morphology (HP:0005938)2.07541782
53Protruding tongue (HP:0010808)2.06735476
54Long clavicles (HP:0000890)2.04194371
55Gaze-evoked nystagmus (HP:0000640)2.03267290
56Impaired smooth pursuit (HP:0007772)2.01672764
57Methylmalonic acidemia (HP:0002912)2.00168800
58Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99694843
59Nephrogenic diabetes insipidus (HP:0009806)1.97616871
60Abnormal albumin level (HP:0012116)1.97436065
61Hypoalbuminemia (HP:0003073)1.97436065
62Stomatitis (HP:0010280)1.96151475
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.95111859
64Inability to walk (HP:0002540)1.94537880
65Abnormal delayed hypersensitivity skin test (HP:0002963)1.94444438
66Abnormality of incisor morphology (HP:0011063)1.93456525
67Polyuria (HP:0000103)1.91240215
68Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90954435
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90954435
70Genetic anticipation (HP:0003743)1.90276990
71Attenuation of retinal blood vessels (HP:0007843)1.89228210
72Congenital hepatic fibrosis (HP:0002612)1.89089720
73Type II lissencephaly (HP:0007260)1.88790346
74Chronic otitis media (HP:0000389)1.88533510
75Tachypnea (HP:0002789)1.88147108
76Hypoplastic iliac wings (HP:0002866)1.88146692
77Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.87456483
78Hypobetalipoproteinemia (HP:0003563)1.86894420
79Progressive inability to walk (HP:0002505)1.85368672
80Hypochromic anemia (HP:0001931)1.84937004
81Breast hypoplasia (HP:0003187)1.84561576
82Anencephaly (HP:0002323)1.84408862
83Colon cancer (HP:0003003)1.81771482
84Abdominal situs inversus (HP:0003363)1.81647585
85Abnormality of abdominal situs (HP:0011620)1.81647585
86Stenosis of the external auditory canal (HP:0000402)1.80704156
87Postaxial hand polydactyly (HP:0001162)1.80330354
88Male pseudohermaphroditism (HP:0000037)1.79600307
89Short phalanx of the thumb (HP:0009660)1.78896900
90Rectovaginal fistula (HP:0000143)1.75260050
91Rectal fistula (HP:0100590)1.75260050
92Chorioretinal atrophy (HP:0000533)1.74311543
93Glycosuria (HP:0003076)1.73278268
94Abnormality of urine glucose concentration (HP:0011016)1.73278268
95Hyperventilation (HP:0002883)1.71150154
96Clumsiness (HP:0002312)1.65137170
97Amelogenesis imperfecta (HP:0000705)1.64738783
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.62207327
99Short tibia (HP:0005736)1.62135074
100Broad-based gait (HP:0002136)1.61997871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.87862869
2TLK14.58365504
3ADRBK22.64932959
4MAP4K22.58717402
5FGFR22.52090076
6WNK42.39710327
7WNK32.33363999
8ZAK2.24473600
9BMPR1B2.20599529
10GRK12.09647636
11PIK3CA2.09400060
12NUAK12.05536286
13INSRR1.91415586
14DAPK21.85887581
15STK391.85865687
16ACVR1B1.83987613
17PAK31.78052332
18MAP3K41.74587835
19TAOK31.61052274
20PINK11.59888349
21CASK1.59229550
22TNIK1.41182749
23FGFR11.28724002
24SGK21.25694955
25TXK1.11584112
26MAPK131.10550516
27OXSR11.09140477
28MAP2K71.08964371
29STK161.00376861
30MKNK20.99794752
31PLK20.99085322
32CSNK1G30.98752954
33RPS6KA50.97488570
34CSNK1G10.97371816
35CSNK1G20.96942164
36VRK10.96317080
37PLK40.93205702
38TRIM280.91780517
39TNK20.91521984
40TEC0.90957573
41CSNK1A1L0.89224667
42TIE10.88695477
43IKBKB0.88349812
44PLK10.87818663
45PTK2B0.87609041
46NEK10.86538678
47PRKCE0.86026955
48ADRBK10.83960181
49SGK4940.83889831
50SGK2230.83889831
51BMPR20.76495814
52PHKG10.76238498
53PHKG20.76238498
54CSNK1A10.72399926
55PRKCG0.68802438
56MST40.68624727
57CAMK2A0.67757237
58BTK0.64485953
59PLK30.62570052
60PRKACA0.62224787
61ATR0.61363520
62DYRK20.60673161
63EIF2AK30.57795824
64BRSK20.57591300
65ERBB30.57458509
66PRKCZ0.56946409
67CAMKK20.56473605
68MAP2K20.56102718
69STK30.56015800
70NME10.55475230
71STK110.55117720
72OBSCN0.55104898
73GRK70.54946041
74TGFBR10.54936671
75CSNK1D0.54581736
76BCR0.54168119
77MUSK0.53350095
78MAPK150.52827592
79STK38L0.52414274
80BCKDK0.51813684
81LCK0.49741181
82AKT30.48416326
83PIM10.47784464
84PNCK0.47429244
85MAP2K60.44817073
86KIT0.44602654
87PRKD20.44440888
88MKNK10.43401110
89PKN10.42207476
90RPS6KA60.40812508
91PRKCQ0.39328927
92NEK60.37847049
93DYRK1A0.36484405
94MARK10.36476753
95PASK0.35570017
96ATM0.35522093
97PRKCA0.35287851
98PRKACB0.34574495
99ABL10.34335112
100SGK30.34222793

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005335.91330486
2Linoleic acid metabolism_Homo sapiens_hsa005913.60091791
3Caffeine metabolism_Homo sapiens_hsa002323.55778256
4Phototransduction_Homo sapiens_hsa047443.42279853
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.42130208
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.35980444
7Ether lipid metabolism_Homo sapiens_hsa005653.31351235
8Nitrogen metabolism_Homo sapiens_hsa009103.10496518
9Folate biosynthesis_Homo sapiens_hsa007902.94414760
10One carbon pool by folate_Homo sapiens_hsa006702.73665157
11Sulfur relay system_Homo sapiens_hsa041222.30605932
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.20039087
13Vitamin digestion and absorption_Homo sapiens_hsa049772.01390291
14Selenocompound metabolism_Homo sapiens_hsa004501.95134280
15Tryptophan metabolism_Homo sapiens_hsa003801.83332035
16Oxidative phosphorylation_Homo sapiens_hsa001901.78625047
17Protein export_Homo sapiens_hsa030601.76735291
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54724609
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50415562
20Arachidonic acid metabolism_Homo sapiens_hsa005901.45459826
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39987172
22Nicotine addiction_Homo sapiens_hsa050331.25802904
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16605141
24Butanoate metabolism_Homo sapiens_hsa006501.12557885
25Homologous recombination_Homo sapiens_hsa034401.07129048
26Mineral absorption_Homo sapiens_hsa049781.07119082
27Basal transcription factors_Homo sapiens_hsa030221.04257564
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02403373
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96038888
30Primary immunodeficiency_Homo sapiens_hsa053400.93056036
31Retinol metabolism_Homo sapiens_hsa008300.91424579
32RNA polymerase_Homo sapiens_hsa030200.90802303
33Glycerophospholipid metabolism_Homo sapiens_hsa005640.90465602
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87846947
35Parkinsons disease_Homo sapiens_hsa050120.87372163
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.83131926
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81965087
38Fat digestion and absorption_Homo sapiens_hsa049750.81934754
39Taste transduction_Homo sapiens_hsa047420.78937574
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78802489
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.77729818
42Type I diabetes mellitus_Homo sapiens_hsa049400.76611366
43Ribosome_Homo sapiens_hsa030100.76441980
44Circadian rhythm_Homo sapiens_hsa047100.73576311
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.71631644
46Chemical carcinogenesis_Homo sapiens_hsa052040.67710272
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66619921
48Cardiac muscle contraction_Homo sapiens_hsa042600.66524300
49RNA degradation_Homo sapiens_hsa030180.64776692
50Morphine addiction_Homo sapiens_hsa050320.64170659
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64026618
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63716757
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62805994
54Peroxisome_Homo sapiens_hsa041460.62467366
55Steroid biosynthesis_Homo sapiens_hsa001000.62096116
56Huntingtons disease_Homo sapiens_hsa050160.61386194
57Non-homologous end-joining_Homo sapiens_hsa034500.60427763
58Insulin secretion_Homo sapiens_hsa049110.58662069
59Olfactory transduction_Homo sapiens_hsa047400.58637662
60Graft-versus-host disease_Homo sapiens_hsa053320.57500415
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57314223
62beta-Alanine metabolism_Homo sapiens_hsa004100.56710494
63Propanoate metabolism_Homo sapiens_hsa006400.56481149
64Serotonergic synapse_Homo sapiens_hsa047260.54983119
65Glycerolipid metabolism_Homo sapiens_hsa005610.53663886
66Ovarian steroidogenesis_Homo sapiens_hsa049130.52751094
67Alzheimers disease_Homo sapiens_hsa050100.50213284
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47750877
69Proteasome_Homo sapiens_hsa030500.46318401
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46176504
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45164994
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44810872
73Dorso-ventral axis formation_Homo sapiens_hsa043200.44264693
74Metabolic pathways_Homo sapiens_hsa011000.44230585
75Fanconi anemia pathway_Homo sapiens_hsa034600.44208839
76GABAergic synapse_Homo sapiens_hsa047270.43861459
77Asthma_Homo sapiens_hsa053100.43227265
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41946522
79Regulation of autophagy_Homo sapiens_hsa041400.41774771
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40634220
81Autoimmune thyroid disease_Homo sapiens_hsa053200.40579583
82Allograft rejection_Homo sapiens_hsa053300.40249509
83ABC transporters_Homo sapiens_hsa020100.35305485
84Glutamatergic synapse_Homo sapiens_hsa047240.34906358
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30176632
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29981573
87Fatty acid degradation_Homo sapiens_hsa000710.26257661
88Dopaminergic synapse_Homo sapiens_hsa047280.26079071
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.25435228
90Circadian entrainment_Homo sapiens_hsa047130.25412596
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.25125220
92Histidine metabolism_Homo sapiens_hsa003400.23562454
93Collecting duct acid secretion_Homo sapiens_hsa049660.22130275
94Purine metabolism_Homo sapiens_hsa002300.22069224
95Calcium signaling pathway_Homo sapiens_hsa040200.21213095
96Sulfur metabolism_Homo sapiens_hsa009200.19891321
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16236976
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15257219
99p53 signaling pathway_Homo sapiens_hsa041150.14295786
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13439321

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