TUSC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)9.97388352
2detection of temperature stimulus involved in sensory perception (GO:0050961)9.97388352
3detection of temperature stimulus (GO:0016048)9.08724543
4negative regulation of dendrite morphogenesis (GO:0050774)8.68842216
5peripheral nervous system neuron development (GO:0048935)8.46846076
6neurofilament cytoskeleton organization (GO:0060052)7.34180578
7negative regulation of calcium ion transport into cytosol (GO:0010523)7.07327000
8transcytosis (GO:0045056)6.68357948
9glycerolipid catabolic process (GO:0046503)6.53770946
10cell migration in hindbrain (GO:0021535)6.30143930
11lipid storage (GO:0019915)5.68284112
12diacylglycerol metabolic process (GO:0046339)5.58213934
13negative regulation of homotypic cell-cell adhesion (GO:0034111)5.56925688
14negative regulation of dendrite development (GO:2000171)5.52779209
15protein heterotrimerization (GO:0070208)5.41681644
16fatty acid homeostasis (GO:0055089)5.38773841
17NADH metabolic process (GO:0006734)5.27761463
18negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)5.21933570
19ovulation from ovarian follicle (GO:0001542)4.96601936
20negative regulation of granulocyte differentiation (GO:0030853)4.91991124
21lipid particle organization (GO:0034389)4.88076162
22neuronal action potential (GO:0019228)4.80506062
23polyol transport (GO:0015791)4.80000443
24regulation of cholesterol storage (GO:0010885)4.79198835
25white fat cell differentiation (GO:0050872)4.72459786
26ethanol oxidation (GO:0006069)4.61402435
27plasma lipoprotein particle clearance (GO:0034381)4.55680712
28positive regulation of lipid storage (GO:0010884)4.53085986
29brown fat cell differentiation (GO:0050873)4.50537024
30negative regulation of macrophage differentiation (GO:0045650)4.49135741
31cellular response to epinephrine stimulus (GO:0071872)4.46455136
32regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.38080184
33calcium-mediated signaling using intracellular calcium source (GO:0035584)4.37934926
34neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.36153511
35innervation (GO:0060384)4.30734523
36retina vasculature morphogenesis in camera-type eye (GO:0061299)4.30189567
37negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.28728982
38regulation of platelet aggregation (GO:0090330)4.28216230
39neuronal action potential propagation (GO:0019227)4.20276962
40negative regulation of amino acid transport (GO:0051956)4.19725502
41negative regulation of protein autophosphorylation (GO:0031953)4.19350365
42positive regulation of cholesterol efflux (GO:0010875)4.17593964
43triglyceride metabolic process (GO:0006641)4.17207927
44regulation of gonadotropin secretion (GO:0032276)4.16136236
45biotin metabolic process (GO:0006768)4.15467413
46triglyceride biosynthetic process (GO:0019432)4.10695494
47negative regulation of smooth muscle cell migration (GO:0014912)4.07167970
48positive regulation of cellular response to insulin stimulus (GO:1900078)4.05635875
49positive regulation of triglyceride lipase activity (GO:0061365)4.03977477
50positive regulation of lipoprotein lipase activity (GO:0051006)4.03977477
51membrane depolarization during action potential (GO:0086010)4.00634089
52negative regulation of phagocytosis (GO:0050765)4.00099261
53proline transport (GO:0015824)3.98565199
54response to phenylpropanoid (GO:0080184)3.96171392
55establishment of mitochondrion localization (GO:0051654)3.93134466
56acylglycerol biosynthetic process (GO:0046463)3.89626356
57neutral lipid biosynthetic process (GO:0046460)3.89626356
58neuron fate specification (GO:0048665)3.89461435
59CDP-diacylglycerol biosynthetic process (GO:0016024)3.89288058
60acylglycerol metabolic process (GO:0006639)3.86413230
61regulation of macrophage derived foam cell differentiation (GO:0010743)3.82839829
62neutral lipid metabolic process (GO:0006638)3.80907080
63negative regulation of metanephros development (GO:0072217)3.80545478
64CDP-diacylglycerol metabolic process (GO:0046341)3.80226003
65negative regulation of gluconeogenesis (GO:0045721)3.79273814
66cellular response to nicotine (GO:0071316)3.78492037
67response to water (GO:0009415)3.73828425
68establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.73740960
69mitochondrion transport along microtubule (GO:0047497)3.73740960
70regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.73423001
71positive regulation of glucose import (GO:0046326)3.73398209
72positive regulation of insulin receptor signaling pathway (GO:0046628)3.71501301
73regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.67864566
74positive regulation of glycolytic process (GO:0045821)3.67556166
75negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.66568099
76oxaloacetate metabolic process (GO:0006107)3.64754120
77cranial nerve development (GO:0021545)3.64274414
78response to epinephrine (GO:0071871)3.64005209
79regulation of receptor binding (GO:1900120)3.62872559
80regulation of glycogen (starch) synthase activity (GO:2000465)3.59607781
81glomerular filtration (GO:0003094)3.59014184
82positive regulation of cholesterol transport (GO:0032376)3.57704845
83positive regulation of sterol transport (GO:0032373)3.57704845
84protein localization to cell surface (GO:0034394)3.51088111
85valine metabolic process (GO:0006573)3.50626994
86regulation of triglyceride catabolic process (GO:0010896)3.49551825
87response to pain (GO:0048265)3.49106010
88regulation of lipoprotein metabolic process (GO:0050746)3.48304494
89ethanol metabolic process (GO:0006067)3.47874093
90response to acidic pH (GO:0010447)3.47232051
91cGMP-mediated signaling (GO:0019934)3.46741102
92behavioral response to pain (GO:0048266)3.45765814
93detection of mechanical stimulus involved in sensory perception (GO:0050974)3.44844324
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44799420
95primary alcohol metabolic process (GO:0034308)3.44272385
96barbed-end actin filament capping (GO:0051016)3.43140552
97positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.43069229
98negative regulation of DNA biosynthetic process (GO:2000279)3.42766929
99negative regulation of neurological system process (GO:0031645)3.40450090
100enteric nervous system development (GO:0048484)3.37915570
101regulation of lipid storage (GO:0010883)3.37356250
102cellular response to leptin stimulus (GO:0044320)3.34090939
103negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.33194741
104positive regulation of metanephros development (GO:0072216)3.29253960
105negative regulation of smooth muscle cell proliferation (GO:0048662)3.28434819
106tyrosine phosphorylation of STAT protein (GO:0007260)3.27909631
107retinal ganglion cell axon guidance (GO:0031290)3.27675356
108phosphatidic acid biosynthetic process (GO:0006654)3.27305173
109phosphatidic acid metabolic process (GO:0046473)3.27305173
110triglyceride homeostasis (GO:0070328)3.26198594
111acylglycerol homeostasis (GO:0055090)3.26198594
112intermediate filament organization (GO:0045109)3.25617546
113inositol phosphate catabolic process (GO:0071545)3.25160860
114glycerol metabolic process (GO:0006071)3.24691524
115regulation of NFAT protein import into nucleus (GO:0051532)3.23354147
116angiogenesis involved in wound healing (GO:0060055)3.22685355
117cellular response to vitamin (GO:0071295)3.22359751
118regulation of relaxation of muscle (GO:1901077)3.21064538
119cellular response to lithium ion (GO:0071285)3.20414884
120negative regulation of lipid catabolic process (GO:0050995)3.19868204
121renal filtration (GO:0097205)3.18632877
122positive regulation of glucose transport (GO:0010828)3.17686768
123response to vitamin E (GO:0033197)3.15940730
124negative regulation of response to food (GO:0032096)3.15563922
125negative regulation of appetite (GO:0032099)3.15563922
126negative regulation of smooth muscle contraction (GO:0045986)3.14320725
127regulation of glomerulus development (GO:0090192)3.13884411
128nerve growth factor signaling pathway (GO:0038180)3.13215820
129positive regulation of fatty acid metabolic process (GO:0045923)3.12537339
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11662965
131regulation of cAMP-dependent protein kinase activity (GO:2000479)3.11401619
132negative regulation of platelet activation (GO:0010544)3.10635086
133triglyceride catabolic process (GO:0019433)3.10373362
134negative regulation of cation channel activity (GO:2001258)3.10342538
135endocrine hormone secretion (GO:0060986)3.09814963
136endothelium development (GO:0003158)3.09753145
137response to leptin (GO:0044321)3.09739943
138negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.09087108
139cell communication involved in cardiac conduction (GO:0086065)3.08486744
140carnitine shuttle (GO:0006853)3.06008496
141regulation of sodium ion transmembrane transporter activity (GO:2000649)2.99233769
142nerve development (GO:0021675)2.97005275
143regulation of cell communication by electrical coupling (GO:0010649)2.95239966
144axon development (GO:0061564)2.95060864
145fatty acid transmembrane transport (GO:1902001)2.94823387
146action potential (GO:0001508)2.94741518
147suckling behavior (GO:0001967)2.91614367
148acrosome reaction (GO:0007340)2.90001817
149potassium ion export (GO:0071435)2.88280864
150regulation of sequestering of triglyceride (GO:0010889)2.83160666
151regulation of protein heterodimerization activity (GO:0043497)2.79578187
152neutral lipid catabolic process (GO:0046461)2.77941608
153acylglycerol catabolic process (GO:0046464)2.77941608
154alanine transport (GO:0032328)2.77513821
155G-protein coupled receptor internalization (GO:0002031)2.77425026
156low-density lipoprotein particle clearance (GO:0034383)2.77324345
157regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76491825
158phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.74281399
159positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.71725246
160regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.70538027
161cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70160988
162regulation of homotypic cell-cell adhesion (GO:0034110)2.69029265
163regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67436839
164positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63782621
165intermediate filament-based process (GO:0045103)2.63190683
166activation of protein kinase A activity (GO:0034199)2.62058914
167membrane budding (GO:0006900)2.61096156
168positive regulation of axon extension (GO:0045773)2.60767762
169positive regulation of macrophage differentiation (GO:0045651)2.60752184
170mechanoreceptor differentiation (GO:0042490)2.60439439
171synaptic vesicle maturation (GO:0016188)2.58732822
172urinary tract smooth muscle contraction (GO:0014848)2.58732498
173intermediate filament cytoskeleton organization (GO:0045104)2.58105844
174regulation of cell maturation (GO:1903429)2.57908092
175response to dietary excess (GO:0002021)2.57811205
176long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.57295090
177regulation of protein kinase A signaling (GO:0010738)2.56304037
178positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53145939
179negative regulation of bone resorption (GO:0045779)2.51821275
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51004410
181axon cargo transport (GO:0008088)2.50996700
182organelle transport along microtubule (GO:0072384)2.50927870
183positive regulation of steroid hormone secretion (GO:2000833)2.50756484
184positive regulation of glomerulus development (GO:0090193)2.48605610
185activation of adenylate cyclase activity (GO:0007190)2.47962414
186serotonin receptor signaling pathway (GO:0007210)2.47159309
187negative regulation of membrane potential (GO:0045837)2.46975230
188long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.46971232
189positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.45383096
190sodium ion transmembrane transport (GO:0035725)2.44893457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00683953
2CLOCK_20551151_ChIP-Seq_293T_Human3.38548970
3FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.38009896
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.78664101
5GBX2_23144817_ChIP-Seq_PC3_Human2.77489671
6EZH2_22144423_ChIP-Seq_EOC_Human2.69982315
7TAF15_26573619_Chip-Seq_HEK293_Human2.69933841
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67206958
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57810915
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45696033
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43274810
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41627089
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.40295785
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38131584
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38131584
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35248311
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24192525
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23275629
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.20950138
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17657054
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.17609093
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15130244
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12055464
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09950639
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.09929016
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08241178
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.07791805
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05969610
29ESR1_20079471_ChIP-ChIP_T-47D_Human2.00385028
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98634405
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94630507
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93466104
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89467071
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87827839
35* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85618667
36* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.83991245
37IGF1R_20145208_ChIP-Seq_DFB_Human1.82836066
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.80360887
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.80360887
40ZNF263_19887448_ChIP-Seq_K562_Human1.77786334
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.71310751
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.69252013
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65215443
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.65047711
45* REST_21632747_ChIP-Seq_MESCs_Mouse1.64847237
46AHR_22903824_ChIP-Seq_MCF-7_Human1.64712251
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62901493
48EGR1_19032775_ChIP-ChIP_M12_Human1.61003390
49SMAD4_21799915_ChIP-Seq_A2780_Human1.60426132
50PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.58229765
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57777909
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.57720852
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.56603311
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54468109
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.51620470
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.47959284
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.46030594
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45864071
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43837732
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43039407
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42840185
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.39639266
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38153080
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36128764
65GATA1_22025678_ChIP-Seq_K562_Human1.34998828
66AR_25329375_ChIP-Seq_VCAP_Human1.34787469
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31819873
68P300_19829295_ChIP-Seq_ESCs_Human1.31592660
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.30154252
70* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28837046
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28573095
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26040590
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24786497
74* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24382769
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23719304
76VDR_22108803_ChIP-Seq_LS180_Human1.23268568
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22995411
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21621399
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.20329645
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18342766
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17564796
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.16951811
83STAT3_23295773_ChIP-Seq_U87_Human1.16768757
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16689082
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14933692
86* SA1_22415368_ChIP-Seq_MEFs_Mouse1.14761014
87KDM2B_26808549_Chip-Seq_K562_Human1.13684581
88AR_21572438_ChIP-Seq_LNCaP_Human1.13117580
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13033951
90SOX2_19829295_ChIP-Seq_ESCs_Human1.12906047
91NANOG_19829295_ChIP-Seq_ESCs_Human1.12906047
92LXR_22292898_ChIP-Seq_THP-1_Human1.12228005
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.10970919
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10852190
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.10257834
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10212487
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09054942
98* BCAT_22108803_ChIP-Seq_LS180_Human1.08324035
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07783385
100* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06697293
101CJUN_26792858_Chip-Seq_BT549_Human1.06287365
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05237085
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05132472
104* CTCF_27219007_Chip-Seq_Bcells_Human1.04313755
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03433568
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03254826
107* KDM2B_26808549_Chip-Seq_REH_Human1.02174292
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.02076581
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01094246
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01094246
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00454643
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99971990
113* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99446919
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99012853
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96945159
116PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.96358239
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95556896
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94013213
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93520814
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.93348795
121JUN_21703547_ChIP-Seq_K562_Human0.92982999
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92650942
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.92529608
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92376710
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91632815
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91632815
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91632815
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88926215
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.88797688
130* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88427455
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88257645
132RNF2_27304074_Chip-Seq_NSC_Mouse0.88048693
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87930891
134SOX2_20726797_ChIP-Seq_SW620_Human0.87619628
135* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87595520
136* SOX2_21211035_ChIP-Seq_LN229_Gbm0.86714010
137SMC4_20622854_ChIP-Seq_HELA_Human0.86549555
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86313453
139* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86172651
140VDR_24787735_ChIP-Seq_THP-1_Human0.85893078
141* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85180785
142RARB_27405468_Chip-Seq_BRAIN_Mouse0.84655988
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84358752
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84280468
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.83892276
146KLF4_19829295_ChIP-Seq_ESCs_Human0.83831453
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83703427
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83448256
149IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82860951
150KDM2B_26808549_Chip-Seq_DND41_Human0.81926589
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.81580285
152CBP_21632823_ChIP-Seq_H3396_Human0.79655390
153P68_20966046_ChIP-Seq_HELA_Human0.77477836
154RACK7_27058665_Chip-Seq_MCF-7_Human0.77115890
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76115091
156SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75172593
157* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73804945
158SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73594339
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72535915
160SA1_27219007_Chip-Seq_ERYTHROID_Human0.71631948
161STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70849044
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70343798

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception7.78297569
2MP0006276_abnormal_autonomic_nervous5.21732495
3MP0004270_analgesia4.91817987
4MP0001986_abnormal_taste_sensitivity4.87847521
5MP0001968_abnormal_touch/_nociception4.59128481
6MP0002736_abnormal_nociception_after4.28816913
7MP0004858_abnormal_nervous_system4.00278229
8MP0002733_abnormal_thermal_nociception3.51775011
9MP0002734_abnormal_mechanical_nocicepti3.44564414
10MP0004147_increased_porphyrin_level3.05294612
11MP0001970_abnormal_pain_threshold3.01584434
12MP0005670_abnormal_white_adipose2.78936041
13MP0000372_irregular_coat_pigmentation2.51225466
14MP0006138_congestive_heart_failure2.49466744
15MP0003724_increased_susceptibility_to2.27841932
16MP0003828_pulmonary_edema2.27571669
17MP0005503_abnormal_tendon_morphology2.25495539
18MP0009379_abnormal_foot_pigmentation2.17368697
19MP0001348_abnormal_lacrimal_gland2.16768425
20MP0002876_abnormal_thyroid_physiology2.14081842
21MP0002751_abnormal_autonomic_nervous2.11851012
22MP0004130_abnormal_muscle_cell1.98413873
23MP0002184_abnormal_innervation1.92946838
24MP0003186_abnormal_redox_activity1.85959714
25MP0005167_abnormal_blood-brain_barrier1.82589088
26MP0003868_abnormal_feces_composition1.81471474
27MP0003011_delayed_dark_adaptation1.81390786
28MP0003690_abnormal_glial_cell1.80452937
29MP0002067_abnormal_sensory_capabilities1.80389411
30MP0002272_abnormal_nervous_system1.79692746
31MP0003705_abnormal_hypodermis_morpholog1.78098968
32MP0002837_dystrophic_cardiac_calcinosis1.73730799
33MP0009046_muscle_twitch1.62013941
34MP0005666_abnormal_adipose_tissue1.58649441
35MP0002108_abnormal_muscle_morphology1.58229123
36MP0002638_abnormal_pupillary_reflex1.52735724
37MP0000343_altered_response_to1.52141759
38MP0003329_amyloid_beta_deposits1.44761278
39MP0005535_abnormal_body_temperature1.36906169
40MP0004272_abnormal_basement_membrane1.35284361
41MP0005379_endocrine/exocrine_gland_phen1.30984767
42MP0003279_aneurysm1.30923366
43MP0003950_abnormal_plasma_membrane1.27623993
44MP0001879_abnormal_lymphatic_vessel1.26839969
45MP0005595_abnormal_vascular_smooth1.22759817
46MP0002295_abnormal_pulmonary_circulatio1.20194056
47MP0008260_abnormal_autophagy1.19653564
48MP0001188_hyperpigmentation1.19377460
49MP0010368_abnormal_lymphatic_system1.14751878
50MP0002933_joint_inflammation1.13670540
51MP0000749_muscle_degeneration1.12555383
52MP0000013_abnormal_adipose_tissue1.12482170
53MP0000955_abnormal_spinal_cord1.10644603
54MP0001270_distended_abdomen1.10110808
55MP0003880_abnormal_central_pattern1.09819032
56MP0005647_abnormal_sex_gland1.05852222
57MP0004811_abnormal_neuron_physiology1.05368298
58MP0001542_abnormal_bone_strength1.05316619
59MP0003635_abnormal_synaptic_transmissio1.04770909
60MP0003656_abnormal_erythrocyte_physiolo1.04612658
61MP0003646_muscle_fatigue1.03947904
62MP0003191_abnormal_cellular_cholesterol1.03480704
63MP0001984_abnormal_olfaction1.03426751
64MP0000249_abnormal_blood_vessel1.03142343
65MP0008569_lethality_at_weaning1.02631714
66MP0004185_abnormal_adipocyte_glucose1.01473969
67MP0004215_abnormal_myocardial_fiber1.00779913
68MP0003948_abnormal_gas_homeostasis0.99802849
69MP0003183_abnormal_peptide_metabolism0.99144241
70MP0002971_abnormal_brown_adipose0.98532678
71MP0001958_emphysema0.96799007
72MP0000751_myopathy0.96589917
73MP0005375_adipose_tissue_phenotype0.96551435
74MP0004087_abnormal_muscle_fiber0.96052264
75MP0002909_abnormal_adrenal_gland0.95131669
76MP0000767_abnormal_smooth_muscle0.94139000
77MP0005164_abnormal_response_to0.94048422
78MP0004859_abnormal_synaptic_plasticity0.94012951
79MP0000015_abnormal_ear_pigmentation0.89909632
80MP0000604_amyloidosis0.88505935
81MP0001727_abnormal_embryo_implantation0.87725032
82MP0008775_abnormal_heart_ventricle0.87313510
83MP0001881_abnormal_mammary_gland0.87191433
84MP0009115_abnormal_fat_cell0.85503066
85MP0005334_abnormal_fat_pad0.83949680
86MP0001764_abnormal_homeostasis0.83828780
87MP0002882_abnormal_neuron_morphology0.82546230
88MP0000858_altered_metastatic_potential0.81992978
89MP0004084_abnormal_cardiac_muscle0.81189893
90MP0009745_abnormal_behavioral_response0.80694036
91MP0002229_neurodegeneration0.80074369
92MP0005584_abnormal_enzyme/coenzyme_acti0.79869662
93MP0002009_preneoplasia0.77824012
94MP0000609_abnormal_liver_physiology0.77375065
95MP0002970_abnormal_white_adipose0.75060120
96MP0002063_abnormal_learning/memory/cond0.74873653
97MP0008438_abnormal_cutaneous_collagen0.73948678
98MP0002752_abnormal_somatic_nervous0.73542342
99MP0005448_abnormal_energy_balance0.72521197
100MP0002064_seizures0.72281330
101MP0004142_abnormal_muscle_tone0.71504249
102MP0001299_abnormal_eye_distance/0.70561446
103MP0003633_abnormal_nervous_system0.70297519
104MP0003634_abnormal_glial_cell0.70153418
105MP0002133_abnormal_respiratory_system0.69685770
106MP0005388_respiratory_system_phenotype0.69685770
107MP0002118_abnormal_lipid_homeostasis0.69352992
108MP0004883_abnormal_blood_vessel0.68199382
109MP0002972_abnormal_cardiac_muscle0.67999829
110MP0003566_abnormal_cell_adhesion0.67759799
111MP0003953_abnormal_hormone_level0.67639220
112MP0000230_abnormal_systemic_arterial0.67150234
113MP0010329_abnormal_lipoprotein_level0.66629009
114MP0005275_abnormal_skin_tensile0.64873812
115MP0001919_abnormal_reproductive_system0.64441276
116MP0002066_abnormal_motor_capabilities/c0.64119231
117MP0001501_abnormal_sleep_pattern0.63673562
118MP0006036_abnormal_mitochondrial_physio0.63424943
119MP0004924_abnormal_behavior0.63183242
120MP0005386_behavior/neurological_phenoty0.63183242
121MP0002572_abnormal_emotion/affect_behav0.62988294
122MP0005409_darkened_coat_color0.62966566
123MP0004085_abnormal_heartbeat0.62851675
124MP0003879_abnormal_hair_cell0.62801362
125MP0001963_abnormal_hearing_physiology0.61321419
126MP0003959_abnormal_lean_body0.60726189
127MP0005508_abnormal_skeleton_morphology0.59486773
128MP0000759_abnormal_skeletal_muscle0.59090946
129MP0003075_altered_response_to0.59036634
130MP0002078_abnormal_glucose_homeostasis0.58786641
131MP0003045_fibrosis0.58528790
132MP0005365_abnormal_bile_salt0.58244752
133MP0002796_impaired_skin_barrier0.57850459
134MP0001661_extended_life_span0.56864759
135MP0005385_cardiovascular_system_phenoty0.56603563
136MP0001544_abnormal_cardiovascular_syste0.56603563
137MP0002160_abnormal_reproductive_system0.55465774
138MP0009780_abnormal_chondrocyte_physiolo0.55385289
139MP0008874_decreased_physiological_sensi0.55231440
140MP0002060_abnormal_skin_morphology0.54981158
141MP0001486_abnormal_startle_reflex0.54585815
142MP0004036_abnormal_muscle_relaxation0.54409521
143MP0010630_abnormal_cardiac_muscle0.53699115
144MP0009643_abnormal_urine_homeostasis0.53379403
145MP0003448_altered_tumor_morphology0.52222730
146MP0000778_abnormal_nervous_system0.50821040
147MP0000003_abnormal_adipose_tissue0.50748851
148MP0005452_abnormal_adipose_tissue0.50542597
149MP0005620_abnormal_muscle_contractility0.50187220
150MP0002166_altered_tumor_susceptibility0.49981123
151MP0001944_abnormal_pancreas_morphology0.48744735
152MP0001177_atelectasis0.48449739
153MP0003091_abnormal_cell_migration0.48095420
154MP0005369_muscle_phenotype0.48044277
155MP0005266_abnormal_metabolism0.47296108
156MP0001614_abnormal_blood_vessel0.47082562
157MP0005397_hematopoietic_system_phenotyp0.47038609
158MP0001545_abnormal_hematopoietic_system0.47038609
159MP0001533_abnormal_skeleton_physiology0.46506835
160MP0002128_abnormal_blood_circulation0.46161567
161MP0005165_increased_susceptibility_to0.45868804

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)7.73369601
2Action tremor (HP:0002345)6.87074373
3Myokymia (HP:0002411)5.72148382
4Hypothermia (HP:0002045)5.71498514
5Increased variability in muscle fiber diameter (HP:0003557)5.20008240
6Protrusio acetabuli (HP:0003179)5.17586028
7Abnormality of pain sensation (HP:0010832)5.11333177
8Impaired pain sensation (HP:0007328)5.11333177
9Dysautonomia (HP:0002459)4.96847725
10Insulin resistance (HP:0000855)4.84576938
11Termporal pattern (HP:0011008)4.58991125
12Insidious onset (HP:0003587)4.58991125
13Pheochromocytoma (HP:0002666)4.50436310
14Difficulty running (HP:0009046)4.49794194
15Oligomenorrhea (HP:0000876)4.46224517
16Abnormality of skeletal muscle fiber size (HP:0012084)4.36433975
17Neuroendocrine neoplasm (HP:0100634)4.27950356
18Segmental peripheral demyelination/remyelination (HP:0003481)4.04376677
19Autoamputation (HP:0001218)3.88483675
20Hyperlipoproteinemia (HP:0010980)3.85866122
21Muscle fiber splitting (HP:0003555)3.82351834
22Myocardial infarction (HP:0001658)3.79836966
23Bradycardia (HP:0001662)3.72834689
24Febrile seizures (HP:0002373)3.70349830
25Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.69233408
26Insulin-resistant diabetes mellitus (HP:0000831)3.64819772
27Hemorrhage of the eye (HP:0011885)3.64016805
28Bone cyst (HP:0012062)3.62950892
29Spinal rigidity (HP:0003306)3.56522896
30Steppage gait (HP:0003376)3.56515193
31Atonic seizures (HP:0010819)3.51284140
32Hypercortisolism (HP:0001578)3.51131451
33Complement deficiency (HP:0004431)3.48983654
34Pigmentary retinal degeneration (HP:0001146)3.40864364
35Foot dorsiflexor weakness (HP:0009027)3.39306739
36Aortic aneurysm (HP:0004942)3.29647741
37Skin nodule (HP:0200036)3.26588889
38Hammertoe (HP:0001765)3.24796620
39Long foot (HP:0001833)3.19826082
40Arthropathy (HP:0003040)3.19473175
41Vertebral compression fractures (HP:0002953)3.16933874
42Thyroid carcinoma (HP:0002890)3.13433115
43Abnormality of complement system (HP:0005339)3.13254161
44Ectopia lentis (HP:0001083)3.07960314
45Colitis (HP:0002583)3.07625951
46Distal arthrogryposis (HP:0005684)3.05881647
47Epidermoid cyst (HP:0200040)3.05596428
48Reduced subcutaneous adipose tissue (HP:0003758)3.04195550
49Back pain (HP:0003418)3.03776381
50Myotonia (HP:0002486)3.03667862
51Polycythemia (HP:0001901)3.03055616
52Axonal loss (HP:0003447)3.01818976
53Abnormality of the foot musculature (HP:0001436)2.95032950
54Submucous cleft hard palate (HP:0000176)2.87622976
55Abnormal autonomic nervous system physiology (HP:0012332)2.85965468
56Areflexia of lower limbs (HP:0002522)2.84815145
57Hyporeflexia of lower limbs (HP:0002600)2.82641251
58Striae distensae (HP:0001065)2.82620003
59Growth hormone excess (HP:0000845)2.81019956
60Amyloidosis (HP:0011034)2.79224680
61Prominent supraorbital ridges (HP:0000336)2.78141251
62Subcapsular cataract (HP:0000523)2.77610361
63Failure to thrive in infancy (HP:0001531)2.77230413
64Cervical subluxation (HP:0003308)2.73231332
65Lymphangioma (HP:0100764)2.67573404
66Cerebral aneurysm (HP:0004944)2.66977227
67Nausea (HP:0002018)2.66850053
68Abnormality of the vocal cords (HP:0008777)2.66222804
69Shallow orbits (HP:0000586)2.66060293
70Systemic lupus erythematosus (HP:0002725)2.61675109
71Ileus (HP:0002595)2.59305417
72Focal motor seizures (HP:0011153)2.57124936
73Broad metatarsal (HP:0001783)2.56167373
74Hypercholesterolemia (HP:0003124)2.54372772
75Distal sensory impairment (HP:0002936)2.53963826
76Focal seizures (HP:0007359)2.52945690
77Polyphagia (HP:0002591)2.52821065
78Decreased motor nerve conduction velocity (HP:0003431)2.52024843
79Progressive cerebellar ataxia (HP:0002073)2.51990645
80Polar cataract (HP:0010696)2.51895074
81Neck muscle weakness (HP:0000467)2.51665737
82Neoplasm of the peripheral nervous system (HP:0100007)2.50472254
83Frequent falls (HP:0002359)2.48442242
84Acanthosis nigricans (HP:0000956)2.48426811
85Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48105075
86Lipoatrophy (HP:0100578)2.48104390
87Abnormal hemoglobin (HP:0011902)2.44359452
88Palpitations (HP:0001962)2.44089519
89Accelerated skeletal maturation (HP:0005616)2.43188396
90Xanthomatosis (HP:0000991)2.42787839
91Episodic fever (HP:0001954)2.42441842
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40890227
93Distal lower limb muscle weakness (HP:0009053)2.38878825
94Vascular tortuosity (HP:0004948)2.36156800
95Thoracolumbar scoliosis (HP:0002944)2.35005057
96Onion bulb formation (HP:0003383)2.32967276
97Ankle contracture (HP:0006466)2.32130241
98Recurrent corneal erosions (HP:0000495)2.30347318
99Fasciculations (HP:0002380)2.27669312
100Ankle clonus (HP:0011448)2.26041826
101Menstrual irregularities (HP:0000858)2.25808953
102Wormian bones (HP:0002645)2.25428731
103Orthostatic hypotension (HP:0001278)2.22415499
104Infantile muscular hypotonia (HP:0008947)2.21318100
105Easy fatigability (HP:0003388)2.21232719
106Delusions (HP:0000746)2.18244928
107Stridor (HP:0010307)2.18039868
108Abnormality of magnesium homeostasis (HP:0004921)2.17780170
109Mitral valve prolapse (HP:0001634)2.17273536
110Supranuclear gaze palsy (HP:0000605)2.14592610
111Dilatation of the ascending aorta (HP:0005111)2.13795829
112Cerebral hemorrhage (HP:0001342)2.13365944
113Gowers sign (HP:0003391)2.09914932
114Pulmonary artery stenosis (HP:0004415)2.09867832
115Spastic gait (HP:0002064)2.06836842
116Hyperglycinuria (HP:0003108)2.03805253
117Abnormal eating behavior (HP:0100738)2.03457922
118Abnormality of the corticospinal tract (HP:0002492)2.01705721
119Esophageal varix (HP:0002040)2.01573995
120Large hands (HP:0001176)2.00953093
121Hepatic necrosis (HP:0002605)2.00629329
122Venous abnormality (HP:0002624)1.99794406
123Premature rupture of membranes (HP:0001788)1.98627132
124Joint hemorrhage (HP:0005261)1.97956194
125Muscle stiffness (HP:0003552)1.96845708
126Decreased muscle mass (HP:0003199)1.95069641
127Absence seizures (HP:0002121)1.94703433
128Apathy (HP:0000741)1.94663753
129Urinary urgency (HP:0000012)1.94221411
130Glucose intolerance (HP:0000833)1.93960117
131Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93501795
132Lower limb muscle weakness (HP:0007340)1.92118682
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91247734
134Hypoplasia of the brainstem (HP:0002365)1.91247734
135Asymmetric septal hypertrophy (HP:0001670)1.90224015
136Scanning speech (HP:0002168)1.89808262
137Increased serum pyruvate (HP:0003542)1.89355521
138Mutism (HP:0002300)1.87510360
139Hypertriglyceridemia (HP:0002155)1.87483621
140Diminished motivation (HP:0000745)1.87425703
141Abnormality of the periventricular white matter (HP:0002518)1.86631750
142Prolonged bleeding time (HP:0003010)1.86490824
143Knee flexion contracture (HP:0006380)1.85755374
144Gastrointestinal dysmotility (HP:0002579)1.85668309
145Hepatocellular necrosis (HP:0001404)1.85321247
146Impaired proprioception (HP:0010831)1.84647173
147Short tibia (HP:0005736)1.83636589
148Ventricular fibrillation (HP:0001663)1.83492937
149Muscle fibrillation (HP:0010546)1.82833831
150Increased muscle lipid content (HP:0009058)1.82042481
151Delayed gross motor development (HP:0002194)1.82024852
152Hypoventilation (HP:0002791)1.81899754
153Soft skin (HP:0000977)1.80950988
154Arterial tortuosity (HP:0005116)1.80338335
155Obstructive sleep apnea (HP:0002870)1.79810871
156Aortic valve stenosis (HP:0001650)1.79329604
157Abnormality of dental color (HP:0011073)1.79216304
158Hypoalphalipoproteinemia (HP:0003233)1.79175327
159Atrioventricular block (HP:0001678)1.79109441
160Overgrowth (HP:0001548)1.78857692
161Urinary bladder sphincter dysfunction (HP:0002839)1.77902372
162Myoglobinuria (HP:0002913)1.76219225
163Aneurysm (HP:0002617)1.75797110
164Dialeptic seizures (HP:0011146)1.75755188
165Truncal ataxia (HP:0002078)1.74721629
166Aortic dissection (HP:0002647)1.74601622
167Anosmia (HP:0000458)1.73109070
168Hypoplasia of the iris (HP:0007676)1.73077412
169Anxiety (HP:0000739)1.72947897
170Nuclear cataract (HP:0100018)1.72813432
171Megalocornea (HP:0000485)1.72782287
172Increased mean platelet volume (HP:0011877)1.72490918
173Generalized tonic-clonic seizures (HP:0002069)1.72434655
174Depression (HP:0000716)1.72116785
175Venous insufficiency (HP:0005293)1.71796036
176Bulbar palsy (HP:0001283)1.71080865
177Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70957055
178Curly hair (HP:0002212)1.70355199
179Increased connective tissue (HP:0009025)1.68778674
180Retinal dysplasia (HP:0007973)1.68378890
181Abnormality of glycolysis (HP:0004366)1.66401702
182Emphysema (HP:0002097)1.66031133
183Metaphyseal dysplasia (HP:0100255)1.65594817
184Polygenic inheritance (HP:0010982)1.65447802
185Spinal cord lesions (HP:0100561)1.64869677
186Aqueductal stenosis (HP:0002410)1.64348136
187Neonatal onset (HP:0003623)1.63728945
188Chin dimple (HP:0010751)1.63715438
189Emotional lability (HP:0000712)1.63040859
190Aplasia/Hypoplasia of the tibia (HP:0005772)1.62218603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK15.40169846
2TIE14.20218355
3CASK4.08553831
4EPHB23.77138697
5LMTK23.71866764
6MATK3.61053866
7RIPK13.55688916
8DDR23.47657394
9MINK13.43274247
10TGFBR23.34224530
11NTRK33.03214776
12PRKAA23.01747286
13MAPKAPK32.97464899
14CAMK12.56537190
15TESK12.49451955
16SIK32.40048069
17MAP3K62.39873363
18SIK12.35116980
19ERN12.29954621
20SGK22.04885871
21KSR22.02174032
22MAP3K122.01207094
23PDGFRA1.94847236
24SCYL21.88207707
25EEF2K1.88147191
26LIMK11.81714481
27MAPK41.80009972
28MAPK131.78506145
29EPHA31.77161099
30SGK2231.75596407
31SGK4941.75596407
32ABL21.70729624
33MAP2K11.68903788
34NEK91.66494312
35MAP3K131.62277732
36MAP3K21.58394087
37GRK51.52406266
38PHKG11.51145743
39PHKG21.51145743
40ARAF1.50431206
41LATS11.47297946
42FER1.43697216
43CSK1.43519492
44RIPK41.42762753
45RPS6KA21.41946194
46RET1.41640653
47CAMKK21.38800150
48CDK61.37942774
49LATS21.37715245
50SGK31.36227618
51MAPK121.30467153
52CAMK1D1.30084798
53MAP2K41.27375743
54MOS1.24816376
55YES11.20509059
56MAP3K91.19676625
57MAP2K71.16869255
58FGFR31.15033028
59PDK31.08021074
60PDK41.08021074
61FES1.07851157
62KDR1.05750817
63PRPF4B1.03162751
64PDGFRB1.01539873
65PINK11.01295700
66PRKCH1.01036435
67KIT0.97319956
68PRKG20.91542307
69MAP3K40.88430309
70BCKDK0.87696562
71WNK10.86582967
72BCR0.85831051
73MAPK70.85245940
74TNK20.84018477
75NLK0.83649585
76JAK20.79878376
77GSK3A0.79753928
78TYK20.79719729
79ADRBK10.76955976
80CAMK1G0.76486632
81CDC42BPA0.75736333
82PKN10.75697623
83DYRK20.73827163
84PRKG10.73386665
85PAK20.71843483
86MAP3K10.70030545
87CDK90.69907871
88FRK0.69654425
89PDPK10.69137407
90ILK0.68339367
91PKN20.66625999
92CDK40.65858805
93PTK20.65573419
94PRKCG0.64526985
95TRIB30.64332583
96CDK50.63543085
97PAK60.63440841
98DAPK20.62887836
99MAP3K110.62392606
100PDK10.59418419
101JAK30.59091169
102ADRBK20.58869955
103RPS6KB10.58815198
104STK240.58473994
105MARK20.58371008
106MAPK30.57101692
107PRKACB0.54962927
108MARK30.54634711
109PRKD10.54036019
110MTOR0.52460205
111TYRO30.52138563
112PRKCE0.51476339
113MAP3K70.51471774
114CAMKK10.50686871
115PRKD30.49939102
116PRKACG0.49390415
117FGFR40.48986653
118GRK10.45699722
119STK390.45641933
120MAP2K60.44769724
121PAK40.44670222
122BRAF0.44261387
123RPS6KC10.43622990
124RPS6KL10.43622990
125TBK10.43494130
126TTN0.43313572
127CDK140.42466842
128ABL10.42409542
129RPS6KA30.41428453
130STK38L0.41077604
131IRAK10.40350142
132MST1R0.39781125
133KSR10.39229418
134INSR0.38121286
135AKT20.38093635
136STK380.37701686
137PRKD20.37606708
138PIM20.36745398
139CAMK2G0.36498213
140SRC0.36360900
141WNK40.35873663
142HIPK20.35610819
143MAP2K20.35275840
144ERBB20.35127505
145DAPK30.34784235
146MARK10.34403991
147PRKACA0.34160385
148MAPK10.34000826
149MAPKAPK50.33938848
150AURKA0.33446498
151DMPK0.32422572
152RPS6KA60.32126488
153IGF1R0.32124426
154EPHB10.30733268
155PRKAA10.30609701
156ZAP700.30168892
157MAP2K30.30130907
158PDK20.29253958
159TRPM70.28963618
160IRAK20.28168687
161AKT30.27788868
162GRK70.27311433
163JAK10.27064679
164MUSK0.25637155
165ROCK10.24195314
166MYLK0.23997782

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.63701556
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.37857677
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.94206459
4Synaptic vesicle cycle_Homo sapiens_hsa047212.53829112
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50623455
6Thyroid cancer_Homo sapiens_hsa052162.41483709
7Tyrosine metabolism_Homo sapiens_hsa003502.39922879
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37718688
9Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.33958875
10Histidine metabolism_Homo sapiens_hsa003402.23109080
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.22715913
12Propanoate metabolism_Homo sapiens_hsa006402.21021086
13beta-Alanine metabolism_Homo sapiens_hsa004102.20753443
14Olfactory transduction_Homo sapiens_hsa047402.12834772
15Fatty acid biosynthesis_Homo sapiens_hsa000612.10077826
16PPAR signaling pathway_Homo sapiens_hsa033201.92516285
17Fatty acid metabolism_Homo sapiens_hsa012121.83202373
18Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.73683741
19Taste transduction_Homo sapiens_hsa047421.68316278
20Glycerolipid metabolism_Homo sapiens_hsa005611.66092980
21Tryptophan metabolism_Homo sapiens_hsa003801.62449358
22ECM-receptor interaction_Homo sapiens_hsa045121.60850503
23Insulin signaling pathway_Homo sapiens_hsa049101.58845408
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58616303
25Pyruvate metabolism_Homo sapiens_hsa006201.58268041
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57108903
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.56067835
28Fatty acid elongation_Homo sapiens_hsa000621.45127070
29Insulin secretion_Homo sapiens_hsa049111.44062163
30Fatty acid degradation_Homo sapiens_hsa000711.41736734
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.38555701
32Dopaminergic synapse_Homo sapiens_hsa047281.37289014
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31479407
34Cholinergic synapse_Homo sapiens_hsa047251.24661502
35Ovarian steroidogenesis_Homo sapiens_hsa049131.21969645
36Malaria_Homo sapiens_hsa051441.05982250
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05732849
38Renin secretion_Homo sapiens_hsa049241.03593142
39Long-term potentiation_Homo sapiens_hsa047201.01957700
40Glucagon signaling pathway_Homo sapiens_hsa049221.00839089
41Dorso-ventral axis formation_Homo sapiens_hsa043201.00755068
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00664407
43Melanoma_Homo sapiens_hsa052181.00453609
44Focal adhesion_Homo sapiens_hsa045101.00027527
45Salivary secretion_Homo sapiens_hsa049700.99601746
46Endometrial cancer_Homo sapiens_hsa052130.99288674
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.98737663
48Oxidative phosphorylation_Homo sapiens_hsa001900.94680424
49Regulation of autophagy_Homo sapiens_hsa041400.94316645
50AMPK signaling pathway_Homo sapiens_hsa041520.94148030
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93425794
52Circadian entrainment_Homo sapiens_hsa047130.91032757
53Salmonella infection_Homo sapiens_hsa051320.90251251
54Parkinsons disease_Homo sapiens_hsa050120.90099867
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86108319
56ErbB signaling pathway_Homo sapiens_hsa040120.86064417
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.85561834
58GnRH signaling pathway_Homo sapiens_hsa049120.85014765
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84945094
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84107147
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83251719
62Phagosome_Homo sapiens_hsa041450.83228237
63Sulfur relay system_Homo sapiens_hsa041220.82569974
64Alzheimers disease_Homo sapiens_hsa050100.82014796
65Collecting duct acid secretion_Homo sapiens_hsa049660.80574134
66Glioma_Homo sapiens_hsa052140.80344108
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79288577
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79096053
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78601560
70Insulin resistance_Homo sapiens_hsa049310.78592265
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78432300
72Prolactin signaling pathway_Homo sapiens_hsa049170.77159051
73Serotonergic synapse_Homo sapiens_hsa047260.76032554
74Retinol metabolism_Homo sapiens_hsa008300.75532176
75Melanogenesis_Homo sapiens_hsa049160.75262981
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.74031763
77Notch signaling pathway_Homo sapiens_hsa043300.73220522
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72510029
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71391072
80Gastric acid secretion_Homo sapiens_hsa049710.70725206
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69932942
82Vibrio cholerae infection_Homo sapiens_hsa051100.69783603
83VEGF signaling pathway_Homo sapiens_hsa043700.68688700
84Oocyte meiosis_Homo sapiens_hsa041140.66458554
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.66151129
86Gap junction_Homo sapiens_hsa045400.65996776
87Calcium signaling pathway_Homo sapiens_hsa040200.65730953
88Cardiac muscle contraction_Homo sapiens_hsa042600.65617496
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64068154
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63073596
91Thyroid hormone synthesis_Homo sapiens_hsa049180.63031826
92Complement and coagulation cascades_Homo sapiens_hsa046100.62467965
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.62305936
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61942909
95Lysine degradation_Homo sapiens_hsa003100.61690055
96Type II diabetes mellitus_Homo sapiens_hsa049300.61104614
97Endocytosis_Homo sapiens_hsa041440.60999418
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60873056
99Acute myeloid leukemia_Homo sapiens_hsa052210.60803579
100Dilated cardiomyopathy_Homo sapiens_hsa054140.60758549
101Glutamatergic synapse_Homo sapiens_hsa047240.60027358
102Butanoate metabolism_Homo sapiens_hsa006500.59358439
103Carbon metabolism_Homo sapiens_hsa012000.58081385
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55428166
105Peroxisome_Homo sapiens_hsa041460.54968254
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.54553703
107cAMP signaling pathway_Homo sapiens_hsa040240.54476152
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54473916
109Morphine addiction_Homo sapiens_hsa050320.53977290
110Glutathione metabolism_Homo sapiens_hsa004800.53412216
111Renin-angiotensin system_Homo sapiens_hsa046140.53003520
112Huntingtons disease_Homo sapiens_hsa050160.51364883
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51225074
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49689532
115Vitamin digestion and absorption_Homo sapiens_hsa049770.47792520
116Staphylococcus aureus infection_Homo sapiens_hsa051500.45438119
117Fat digestion and absorption_Homo sapiens_hsa049750.45213413
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44872744
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44455785
120Oxytocin signaling pathway_Homo sapiens_hsa049210.44387257
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42850795
122Estrogen signaling pathway_Homo sapiens_hsa049150.42815681
123Chemical carcinogenesis_Homo sapiens_hsa052040.41965792
124Protein digestion and absorption_Homo sapiens_hsa049740.40749200
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38408307
126Ras signaling pathway_Homo sapiens_hsa040140.37899529
127Phototransduction_Homo sapiens_hsa047440.37403958
128Long-term depression_Homo sapiens_hsa047300.37241042
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37120182
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.36514477
131Rap1 signaling pathway_Homo sapiens_hsa040150.36171737
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34836474
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33991570
134Pancreatic secretion_Homo sapiens_hsa049720.32770969
135Adherens junction_Homo sapiens_hsa045200.31566218
136Folate biosynthesis_Homo sapiens_hsa007900.29126199
137Proteoglycans in cancer_Homo sapiens_hsa052050.28881228
138Bile secretion_Homo sapiens_hsa049760.28303844
139Arginine and proline metabolism_Homo sapiens_hsa003300.27120572
140Platelet activation_Homo sapiens_hsa046110.26725189
141Circadian rhythm_Homo sapiens_hsa047100.26027963
142ABC transporters_Homo sapiens_hsa020100.25842969
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24409553
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.23496595
145Pathways in cancer_Homo sapiens_hsa052000.21416741
146Sulfur metabolism_Homo sapiens_hsa009200.18899676
147Arginine biosynthesis_Homo sapiens_hsa002200.16744941
148Other glycan degradation_Homo sapiens_hsa005110.16541107
149Vitamin B6 metabolism_Homo sapiens_hsa007500.16523160
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15701189
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15430201
152FoxO signaling pathway_Homo sapiens_hsa040680.15179746
153Axon guidance_Homo sapiens_hsa043600.15091063
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.14943282
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14343735
156Amoebiasis_Homo sapiens_hsa051460.14246231
157Cocaine addiction_Homo sapiens_hsa050300.13672732

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