TUFT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.37758771
2establishment of skin barrier (GO:0061436)7.89364207
3regulation of water loss via skin (GO:0033561)7.79135575
4interferon-gamma secretion (GO:0072643)6.19074166
5hemidesmosome assembly (GO:0031581)5.94188421
6keratinization (GO:0031424)5.63837500
7bundle of His cell to Purkinje myocyte communication (GO:0086069)5.48802640
8multicellular organismal water homeostasis (GO:0050891)5.44831628
9water homeostasis (GO:0030104)4.77916307
10keratinocyte differentiation (GO:0030216)4.73428495
11intestinal epithelial cell development (GO:0060576)4.64835599
12sphingoid metabolic process (GO:0046519)4.36941646
13glucosamine-containing compound catabolic process (GO:1901072)4.29754314
14negative regulation of keratinocyte proliferation (GO:0010839)4.26534271
15sphingosine metabolic process (GO:0006670)4.25071149
16keratinocyte proliferation (GO:0043616)4.22844848
17positive regulation of Cdc42 GTPase activity (GO:0043089)3.78584766
18molting cycle (GO:0042303)3.77488105
19hair cycle (GO:0042633)3.77488105
20diol metabolic process (GO:0034311)3.76727639
21epidermal cell differentiation (GO:0009913)3.76226159
22skin morphogenesis (GO:0043589)3.71204961
23peptide catabolic process (GO:0043171)3.59219466
24Golgi transport vesicle coating (GO:0048200)3.58290126
25COPI coating of Golgi vesicle (GO:0048205)3.58290126
26hepatocyte apoptotic process (GO:0097284)3.55190517
27folic acid transport (GO:0015884)3.54745384
28tight junction assembly (GO:0070830)3.52596229
29keratinocyte development (GO:0003334)3.47313569
30polarized epithelial cell differentiation (GO:0030859)3.40951113
31amino sugar catabolic process (GO:0046348)3.36061866
32regulation of transforming growth factor beta1 production (GO:0032908)3.34100512
33calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.26902995
34membrane budding (GO:0006900)3.23715111
35peptide cross-linking (GO:0018149)3.23075185
36cyclooxygenase pathway (GO:0019371)3.18294835
37regulation of chemokine secretion (GO:0090196)3.16679025
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13580534
39regulation of apoptotic process involved in morphogenesis (GO:1902337)3.11023288
40positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.10518316
41epithelial cell-cell adhesion (GO:0090136)3.09538334
42regulation of cell proliferation involved in kidney development (GO:1901722)3.09284188
43ER overload response (GO:0006983)3.07837028
44folic acid metabolic process (GO:0046655)3.05003239
45magnesium ion transport (GO:0015693)3.00427880
46protein K11-linked deubiquitination (GO:0035871)2.92418138
47phospholipid scrambling (GO:0017121)2.91674619
48epidermis development (GO:0008544)2.90975604
49protein retention in ER lumen (GO:0006621)2.89248282
50columnar/cuboidal epithelial cell development (GO:0002066)2.88658629
51regulation of hippo signaling (GO:0035330)2.87865071
52cornea development in camera-type eye (GO:0061303)2.87746712
53positive regulation of interleukin-8 secretion (GO:2000484)2.84740929
54positive regulation of epidermis development (GO:0045684)2.82174090
55negative regulation of cell fate specification (GO:0009996)2.81353322
56response to xenobiotic stimulus (GO:0009410)2.80377996
57negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79665441
58viral transcription (GO:0019083)2.79228601
59ectoderm development (GO:0007398)2.78204808
60intermediate filament organization (GO:0045109)2.77647199
61regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.75677714
62ribosomal small subunit assembly (GO:0000028)2.75404271
63regulation of keratinocyte proliferation (GO:0010837)2.74576532
64detection of bacterium (GO:0016045)2.71508557
65regulation of cholesterol homeostasis (GO:2000188)2.71308112
66surfactant homeostasis (GO:0043129)2.71261945
67lactate metabolic process (GO:0006089)2.70650233
68translational termination (GO:0006415)2.70470495
69fat-soluble vitamin biosynthetic process (GO:0042362)2.70222863
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.70158445
71regulation of cardioblast differentiation (GO:0051890)2.69872087
72maturation of SSU-rRNA (GO:0030490)2.69072873
73pyrimidine-containing compound transmembrane transport (GO:0072531)2.68296361
74vitamin transmembrane transport (GO:0035461)2.68126096
75regulation of phospholipase A2 activity (GO:0032429)2.67122061
76regulation of interleukin-8 secretion (GO:2000482)2.66979174
77diterpenoid biosynthetic process (GO:0016102)2.66932528
78UDP-N-acetylglucosamine metabolic process (GO:0006047)2.66202604
79retinol metabolic process (GO:0042572)2.65640799
80positive regulation of epidermal cell differentiation (GO:0045606)2.64877723
81positive regulation of actin filament depolymerization (GO:0030836)2.62877465
82gland morphogenesis (GO:0022612)2.62870526
83protein targeting to ER (GO:0045047)2.62444457
84retinal metabolic process (GO:0042574)2.62384708
85cardiac right ventricle morphogenesis (GO:0003215)2.61876355
86regulation of acrosome reaction (GO:0060046)2.59991268
87ribosomal large subunit biogenesis (GO:0042273)2.59182118
88regulation of glucokinase activity (GO:0033131)2.59082599
89regulation of hexokinase activity (GO:1903299)2.59082599
90cotranslational protein targeting to membrane (GO:0006613)2.59075331
91hormone catabolic process (GO:0042447)2.58895121
92primary alcohol catabolic process (GO:0034310)2.58653506
93COPII vesicle coating (GO:0048208)2.58352543
94regulation of ruffle assembly (GO:1900027)2.58099311
95negative regulation of dendrite morphogenesis (GO:0050774)2.58060881
96negative regulation of JUN kinase activity (GO:0043508)2.57938978
97atrioventricular valve morphogenesis (GO:0003181)2.56997281
98modified amino acid transport (GO:0072337)2.56953430
99fibroblast migration (GO:0010761)2.56063741
100regulation of keratinocyte differentiation (GO:0045616)2.54045364
101fatty acid elongation (GO:0030497)2.53407340
102sodium-independent organic anion transport (GO:0043252)2.51753518
103proteasome assembly (GO:0043248)2.49682842
104regulation of Cdc42 GTPase activity (GO:0043088)2.49641591
105positive regulation of protein autophosphorylation (GO:0031954)2.48859531
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48304121
107protein localization to endoplasmic reticulum (GO:0070972)2.46874301
108negative regulation of stress fiber assembly (GO:0051497)2.45307229
109cell-cell junction assembly (GO:0007043)2.44855533
110negative regulation of epidermal cell differentiation (GO:0045605)2.44103836
111regulation of epidermis development (GO:0045682)2.42882946
112gap junction assembly (GO:0016264)2.42589889
113lung epithelium development (GO:0060428)2.39364575
114negative regulation of neurological system process (GO:0031645)2.39312885
115cellular response to vitamin D (GO:0071305)2.39212216
116regulation of cell fate specification (GO:0042659)2.39180452
117vitamin transport (GO:0051180)2.39124476
118terpenoid biosynthetic process (GO:0016114)2.38609639
119copper ion transport (GO:0006825)2.38596722
120glandular epithelial cell differentiation (GO:0002067)2.38188288
121purine nucleobase biosynthetic process (GO:0009113)2.36793926
122regulation of type B pancreatic cell apoptotic process (GO:2000674)2.36559703
123regulation of integrin-mediated signaling pathway (GO:2001044)2.36261652
124intestinal absorption (GO:0050892)2.36027284
125translational elongation (GO:0006414)2.34336652
126sphingomyelin metabolic process (GO:0006684)2.31286180
127positive regulation of response to nutrient levels (GO:0032109)2.28229942
128positive regulation of response to extracellular stimulus (GO:0032106)2.28229942
129endocrine hormone secretion (GO:0060986)2.28043504
130positive regulation of macroautophagy (GO:0016239)2.27483834
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27250723
132nucleotide transmembrane transport (GO:1901679)2.27021123
133negative regulation of cell aging (GO:0090344)2.26825945
134regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.25470736
135chemosensory behavior (GO:0007635)2.24079515
136regulation of clathrin-mediated endocytosis (GO:2000369)2.21520791
137regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.20834417
138epithelial cell maturation (GO:0002070)2.18187426
139mannosylation (GO:0097502)2.18129594
140cell adhesion mediated by integrin (GO:0033627)2.16977013
141nucleotide-sugar biosynthetic process (GO:0009226)2.16439606
142respiratory chain complex IV assembly (GO:0008535)2.13148505
143ER to Golgi vesicle-mediated transport (GO:0006888)2.11080671
144auditory receptor cell differentiation (GO:0042491)2.10750135
145peptidyl-cysteine modification (GO:0018198)2.10587115
146dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.10462946
147mammary gland epithelial cell proliferation (GO:0033598)2.09972710
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.09504958
149lipid particle organization (GO:0034389)2.08728904
150positive regulation of growth hormone secretion (GO:0060124)2.08227142
151neural crest cell development (GO:0014032)2.08025750
152C-terminal protein lipidation (GO:0006501)2.07082341
153water-soluble vitamin biosynthetic process (GO:0042364)2.06610779
154regulation of cellular amino acid metabolic process (GO:0006521)2.06019262
155establishment of planar polarity (GO:0001736)2.05997328
156establishment of tissue polarity (GO:0007164)2.05997328
157hippo signaling (GO:0035329)2.05500427
158nephron tubule formation (GO:0072079)2.05137839
159zinc ion transport (GO:0006829)2.05029336
160regulation of transforming growth factor beta2 production (GO:0032909)2.04486265
161macroautophagy (GO:0016236)2.04318934
162ribosome assembly (GO:0042255)2.04217642
163protein localization to microtubule (GO:0035372)2.03409593
164sphingolipid biosynthetic process (GO:0030148)2.02253984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.31517235
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.92073559
3* ESR1_21235772_ChIP-Seq_MCF-7_Human2.81297125
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56013879
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.51913711
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26516664
7GATA1_22025678_ChIP-Seq_K562_Human2.19493049
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.18510392
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.16998934
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14258872
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12367586
12* ESR2_21235772_ChIP-Seq_MCF-7_Human2.11982507
13* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.10343370
14* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.10343370
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.07466134
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03174661
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00935497
18TP63_17297297_ChIP-ChIP_HaCaT_Human12.1516796
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97540979
20GATA4_25053715_ChIP-Seq_YYC3_Human1.97424681
21ZNF263_19887448_ChIP-Seq_K562_Human1.93023238
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91134669
23ZNF274_21170338_ChIP-Seq_K562_Hela1.87785583
24* AHR_22903824_ChIP-Seq_MCF-7_Human1.81744958
25ATF3_27146783_Chip-Seq_COLON_Human1.81658763
26AR_21909140_ChIP-Seq_LNCAP_Human1.81377644
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.81192414
28* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80775524
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.77616842
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.76068316
31* ELK1_19687146_ChIP-ChIP_HELA_Human1.72016176
32SOX2_20726797_ChIP-Seq_SW620_Human1.68430339
33* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65023732
34* GATA6_25053715_ChIP-Seq_YYC3_Human1.62249254
35* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.58761182
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57725041
37* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53640256
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52979432
39* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48975952
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45630702
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44522101
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.43600128
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42782448
44FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.41279109
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39728097
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39646042
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39266731
48* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38024766
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.37945822
50* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.37915995
51RACK7_27058665_Chip-Seq_MCF-7_Human1.36885215
52ELF5_23300383_ChIP-Seq_T47D_Human1.36532924
53* RUNX1_27514584_Chip-Seq_MCF-7_Human1.35239450
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34465174
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34303765
56* GATA3_24758297_ChIP-Seq_MCF-7_Human1.34300329
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33573505
58CLOCK_20551151_ChIP-Seq_293T_Human1.32150378
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31058470
60* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30272584
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.29790476
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.29398607
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29292653
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28267469
65* ELK1_22589737_ChIP-Seq_MCF10A_Human1.27374413
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27138473
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.27004420
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.26739801
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26267611
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25586611
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25281940
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24357590
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24037097
74* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22562599
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21884827
76TP53_18474530_ChIP-ChIP_U2OS_Human1.21294909
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20347389
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19164504
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17981911
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17577065
81* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17467803
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17317786
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17039832
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12977531
85BRD4_25478319_ChIP-Seq_HGPS_Human1.10661981
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08517702
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08410979
88CDX2_22108803_ChIP-Seq_LS180_Human1.08403662
89ER_23166858_ChIP-Seq_MCF-7_Human1.08244712
90* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07498721
91* FUS_26573619_Chip-Seq_HEK293_Human1.07472915
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07058204
93* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06853588
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.06584008
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05361563
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02683222
97KLF5_25053715_ChIP-Seq_YYC3_Human1.00332609
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99485430
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99313647
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98275437
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97935035
102HOXB7_26014856_ChIP-Seq_BT474_Human0.97473442
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97289706
104CHD1_26751641_Chip-Seq_LNCaP_Human0.97184854
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96732618
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96349532
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95232493
108CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94548813
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94168788
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94078424
111KDM5A_27292631_Chip-Seq_BREAST_Human0.92674598
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92403836
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92394366
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90349595
115ETS1_20019798_ChIP-Seq_JURKAT_Human0.90181706
116EST1_17652178_ChIP-ChIP_JURKAT_Human0.89418193
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88707065
118GABP_17652178_ChIP-ChIP_JURKAT_Human0.88520979
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.87773262
120E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86959598
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86944472
122P300_19829295_ChIP-Seq_ESCs_Human0.85760298
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84893120
124DCP1A_22483619_ChIP-Seq_HELA_Human0.84694935
125VDR_22108803_ChIP-Seq_LS180_Human0.83772042
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83675080
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83489418
128TP63_22573176_ChIP-Seq_HFKS_Human0.83352539
129EWS_26573619_Chip-Seq_HEK293_Human0.82817791
130EOMES_21245162_ChIP-Seq_HESCs_Human0.82576783
131HTT_18923047_ChIP-ChIP_STHdh_Human0.81952803
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81529170
133TCF4_22108803_ChIP-Seq_LS180_Human0.81229471
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81140294
135PHF8_20622853_ChIP-Seq_HELA_Human0.81126743
136GABP_19822575_ChIP-Seq_HepG2_Human0.80441887
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80162217
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80162217
139CJUN_26792858_Chip-Seq_BT549_Human0.79731863
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76376458
141* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75933346
142XRN2_22483619_ChIP-Seq_HELA_Human0.74171926
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.71825284
144TP63_23658742_ChIP-Seq_EP156T_Human0.71086122
145NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70735831
146MYC_18358816_ChIP-ChIP_MESCs_Mouse0.69996104
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68797907
148TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.66536457
149* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66497616
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66413260
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65531285
152SOX17_20123909_ChIP-Seq_XEN_Mouse0.64109949
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.63565938
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.63130684
155NANOG_18555785_ChIP-Seq_MESCs_Mouse0.63115086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.06545824
2MP0010234_abnormal_vibrissa_follicle4.92472936
3MP0005501_abnormal_skin_physiology3.54089122
4MP0003941_abnormal_skin_development3.50892367
5MP0005275_abnormal_skin_tensile3.33031181
6MP0009780_abnormal_chondrocyte_physiolo2.90162872
7MP0002060_abnormal_skin_morphology2.75907434
8MP0001216_abnormal_epidermal_layer2.70991612
9MP0002098_abnormal_vibrissa_morphology2.66714575
10MP0003950_abnormal_plasma_membrane2.57464306
11MP0004019_abnormal_vitamin_homeostasis2.27400518
12MP0003453_abnormal_keratinocyte_physiol2.25843507
13MP0010352_gastrointestinal_tract_polyps2.24714493
14MP0010678_abnormal_skin_adnexa2.14898531
15MP0003011_delayed_dark_adaptation2.04454921
16MP0002254_reproductive_system_inflammat1.97586826
17MP0004264_abnormal_extraembryonic_tissu1.97568881
18MP0010771_integument_phenotype1.97376455
19MP0003705_abnormal_hypodermis_morpholog1.93313600
20MP0000377_abnormal_hair_follicle1.90888316
21MP0004381_abnormal_hair_follicle1.87973730
22MP0000579_abnormal_nail_morphology1.87409387
23MP0004947_skin_inflammation1.84041203
24MP0000383_abnormal_hair_follicle1.83191847
25MP0005451_abnormal_body_composition1.81658872
26MP0003693_abnormal_embryo_hatching1.73944379
27MP0003566_abnormal_cell_adhesion1.71103445
28MP0000647_abnormal_sebaceous_gland1.64582246
29MP0001188_hyperpigmentation1.58677053
30MP0009384_cardiac_valve_regurgitation1.54902632
31MP0002877_abnormal_melanocyte_morpholog1.52356120
32MP0000427_abnormal_hair_cycle1.52324506
33MP0009840_abnormal_foam_cell1.50671015
34MP0001666_abnormal_nutrient_absorption1.47332813
35MP0002938_white_spotting1.45483805
36MP0000467_abnormal_esophagus_morphology1.45316694
37MP0001346_abnormal_lacrimal_gland1.40913464
38MP0002909_abnormal_adrenal_gland1.40833625
39MP0000537_abnormal_urethra_morphology1.40161673
40MP0002876_abnormal_thyroid_physiology1.39652184
41MP0004782_abnormal_surfactant_physiolog1.39587773
42MP0001191_abnormal_skin_condition1.36920208
43MP0002139_abnormal_hepatobiliary_system1.36581176
44MP0003755_abnormal_palate_morphology1.34144880
45MP0009931_abnormal_skin_appearance1.33335750
46MP0002163_abnormal_gland_morphology1.33154438
47MP0000566_synostosis1.28367477
48MP0004957_abnormal_blastocyst_morpholog1.28264803
49MP0003123_paternal_imprinting1.27135942
50MP0000762_abnormal_tongue_morphology1.27004720
51MP0002009_preneoplasia1.26238983
52MP0005023_abnormal_wound_healing1.25554567
53MP0002160_abnormal_reproductive_system1.24690928
54MP0004043_abnormal_pH_regulation1.23025704
55MP0008995_early_reproductive_senescence1.22475972
56MP0005379_endocrine/exocrine_gland_phen1.16146555
57MP0005085_abnormal_gallbladder_physiolo1.14037120
58MP0009643_abnormal_urine_homeostasis1.13537004
59MP0002234_abnormal_pharynx_morphology1.13203180
60MP0009379_abnormal_foot_pigmentation1.13180071
61MP0003191_abnormal_cellular_cholesterol1.13074418
62MP0010386_abnormal_urinary_bladder1.12258995
63MP0000367_abnormal_coat/_hair1.10698761
64MP0000003_abnormal_adipose_tissue1.10136410
65MP0005365_abnormal_bile_salt1.09760649
66MP0003195_calcinosis1.09613604
67MP0003786_premature_aging1.09600495
68MP0008004_abnormal_stomach_pH1.07674644
69MP0003300_gastrointestinal_ulcer1.07643175
70MP0001958_emphysema1.07109294
71MP0005360_urolithiasis1.03636738
72MP0001849_ear_inflammation1.03094610
73MP0010030_abnormal_orbit_morphology1.01515571
74MP0003936_abnormal_reproductive_system0.98860070
75MP0003937_abnormal_limbs/digits/tail_de0.96329658
76MP0000627_abnormal_mammary_gland0.96203659
77MP0000678_abnormal_parathyroid_gland0.95666784
78MP0002138_abnormal_hepatobiliary_system0.94690680
79MP0001243_abnormal_dermal_layer0.94376568
80MP0002102_abnormal_ear_morphology0.93816526
81MP0005248_abnormal_Harderian_gland0.93746965
82MP0006054_spinal_hemorrhage0.93723048
83MP0002233_abnormal_nose_morphology0.93479722
84MP0008789_abnormal_olfactory_epithelium0.92935337
85MP0002837_dystrophic_cardiac_calcinosis0.92335654
86MP0008877_abnormal_DNA_methylation0.92306080
87MP0003718_maternal_effect0.91858970
88MP0003806_abnormal_nucleotide_metabolis0.91487992
89MP0001765_abnormal_ion_homeostasis0.91141841
90MP0002090_abnormal_vision0.89567671
91MP0000490_abnormal_crypts_of0.89557637
92MP0008875_abnormal_xenobiotic_pharmacok0.89355778
93MP0003186_abnormal_redox_activity0.86961193
94MP0000516_abnormal_urinary_system0.85808793
95MP0005367_renal/urinary_system_phenotyp0.85808793
96MP0000538_abnormal_urinary_bladder0.84997453
97MP0005670_abnormal_white_adipose0.84895878
98MP0008057_abnormal_DNA_replication0.84482274
99MP0001727_abnormal_embryo_implantation0.83848604
100MP0001944_abnormal_pancreas_morphology0.83046417
101MP0009053_abnormal_anal_canal0.82923416
102MP0005220_abnormal_exocrine_pancreas0.82882670
103MP0000613_abnormal_salivary_gland0.82479574
104MP0003315_abnormal_perineum_morphology0.82127000
105MP0004233_abnormal_muscle_weight0.80671820
106MP0005377_hearing/vestibular/ear_phenot0.79134927
107MP0003878_abnormal_ear_physiology0.79134927
108MP0004272_abnormal_basement_membrane0.78330841
109MP0005666_abnormal_adipose_tissue0.78174049
110MP0002136_abnormal_kidney_physiology0.77756696
111MP0002177_abnormal_outer_ear0.77361342
112MP0002928_abnormal_bile_duct0.74576125
113MP0002653_abnormal_ependyma_morphology0.74405406
114MP0005408_hypopigmentation0.74106185
115MP0002282_abnormal_trachea_morphology0.73955422
116MP0003787_abnormal_imprinting0.73806457
117MP0001529_abnormal_vocalization0.73754907
118MP0003252_abnormal_bile_duct0.73413234
119MP0000750_abnormal_muscle_regeneration0.72341940
120MP0003183_abnormal_peptide_metabolism0.72270372
121MP0008058_abnormal_DNA_repair0.71986817
122MP0002132_abnormal_respiratory_system0.71588592
123MP0001881_abnormal_mammary_gland0.71216359
124MP0001756_abnormal_urination0.71149359
125MP0000358_abnormal_cell_content/0.70069108
126MP0000477_abnormal_intestine_morphology0.68200153
127MP0001340_abnormal_eyelid_morphology0.67789063
128MP0000372_irregular_coat_pigmentation0.66983541
129MP0005636_abnormal_mineral_homeostasis0.66612472
130MP0002277_abnormal_respiratory_mucosa0.66529186
131MP0001984_abnormal_olfaction0.66419776
132MP0002896_abnormal_bone_mineralization0.66021988
133MP0000013_abnormal_adipose_tissue0.65075254
134MP0002697_abnormal_eye_size0.63504466
135MP0005395_other_phenotype0.63371274
136MP0005084_abnormal_gallbladder_morpholo0.63361054
137MP0004185_abnormal_adipocyte_glucose0.62489020
138MP0000462_abnormal_digestive_system0.60844388
139MP0003866_abnormal_defecation0.60441636
140MP0005083_abnormal_biliary_tract0.59414194
141MP0001299_abnormal_eye_distance/0.59031203
142MP0005389_reproductive_system_phenotype0.58558598
143MP0005332_abnormal_amino_acid0.58006120
144MP0003119_abnormal_digestive_system0.57503308
145MP0005551_abnormal_eye_electrophysiolog0.55215606
146MP0005197_abnormal_uvea_morphology0.54090650

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.68920347
2Onycholysis (HP:0001806)4.97406539
3Plantar hyperkeratosis (HP:0007556)4.66435113
4Woolly hair (HP:0002224)4.25035335
5Fragile nails (HP:0001808)4.08646565
6Lip pit (HP:0100267)4.06969841
7Palmoplantar hyperkeratosis (HP:0000972)3.98374403
8Congenital ichthyosiform erythroderma (HP:0007431)3.93879019
9Hypotrichosis (HP:0001006)3.90484466
10Milia (HP:0001056)3.80607492
11Palmar hyperkeratosis (HP:0010765)3.78760370
12Increased IgE level (HP:0003212)3.56233774
13Curly hair (HP:0002212)3.25001976
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.21024654
15Hypoplasia of the uterus (HP:0000013)3.17562862
16Erythema (HP:0010783)3.09287484
17Pili torti (HP:0003777)3.08052072
18Abnormal blistering of the skin (HP:0008066)3.05193934
19Abnormality of the distal phalanges of the toes (HP:0010182)2.96788532
20Aplasia/hypoplasia of the uterus (HP:0008684)2.95306698
21Sparse eyelashes (HP:0000653)2.95028204
22Gout (HP:0001997)2.92071509
23Thin bony cortex (HP:0002753)2.89319786
24Erythroderma (HP:0001019)2.78967585
25Nail dystrophy (HP:0008404)2.77739967
26Natal tooth (HP:0000695)2.70122026
27Hypoplasia of dental enamel (HP:0006297)2.65996640
28Distal lower limb muscle weakness (HP:0009053)2.65168469
29Widely patent fontanelles and sutures (HP:0004492)2.63465979
30Abnormal pancreas size (HP:0012094)2.59998697
31Parakeratosis (HP:0001036)2.58170937
32Abnormality of nail color (HP:0100643)2.56841449
33Vascular calcification (HP:0004934)2.53233316
34Atrophic scars (HP:0001075)2.52075470
35Abnormal hemoglobin (HP:0011902)2.44995258
36Hamartoma of the eye (HP:0010568)2.43258608
37Alopecia of scalp (HP:0002293)2.42485488
38Abnormality of permanent molar morphology (HP:0011071)2.41485094
39Abnormality of the dental root (HP:0006486)2.41485094
40Taurodontia (HP:0000679)2.41485094
41Corneal erosion (HP:0200020)2.40462996
42Abnormality of cells of the erythroid lineage (HP:0012130)2.38324365
43Increased purine levels (HP:0004368)2.36165898
44Hyperuricemia (HP:0002149)2.36165898
45Ileus (HP:0002595)2.33111249
46Delayed epiphyseal ossification (HP:0002663)2.32489135
47Abnormality of the gastric mucosa (HP:0004295)2.31901756
48Popliteal pterygium (HP:0009756)2.31466157
49Micronodular cirrhosis (HP:0001413)2.27588378
50Amelogenesis imperfecta (HP:0000705)2.27501371
51Thick nail (HP:0001805)2.27383578
52Abnormality of molar (HP:0011077)2.26917664
53Abnormality of molar morphology (HP:0011070)2.26917664
54Conjunctival hamartoma (HP:0100780)2.26123455
55Insulin-resistant diabetes mellitus (HP:0000831)2.23475610
56Cardiovascular calcification (HP:0011915)2.23470360
57Depressed nasal tip (HP:0000437)2.23083375
58Hypokinesia (HP:0002375)2.22577077
59Absent eyelashes (HP:0000561)2.20787988
60Follicular hyperkeratosis (HP:0007502)2.20029229
61Abnormal number of erythroid precursors (HP:0012131)2.18862587
62Acanthosis nigricans (HP:0000956)2.18387266
63Ectropion (HP:0000656)2.16441862
64Hypoalphalipoproteinemia (HP:0003233)2.15281248
65Breast carcinoma (HP:0003002)2.15166428
66Septate vagina (HP:0001153)2.15014613
67Abnormality of the costochondral junction (HP:0000919)2.13408767
68Trismus (HP:0000211)2.13170369
69Hypothermia (HP:0002045)2.12068976
70Abnormality of purine metabolism (HP:0004352)2.10350063
71Dry hair (HP:0011359)2.10029080
72Abnormal biliary tract morphology (HP:0012440)2.08968517
73Abnormality of the dental pulp (HP:0006479)2.08357443
74Chronic bronchitis (HP:0004469)2.08063524
75Abdominal distention (HP:0003270)2.07007983
76Hyperglycemia (HP:0003074)2.05918780
77Tubular atrophy (HP:0000092)2.05663978
78Abnormality of the labia majora (HP:0012881)2.05660163
79Biliary tract neoplasm (HP:0100574)2.05285257
80Concave nail (HP:0001598)2.05147487
81Adrenal hypoplasia (HP:0000835)2.04577955
82Generalized aminoaciduria (HP:0002909)2.04167697
83Enlarged epiphyses (HP:0010580)2.02357284
84Intrahepatic cholestasis (HP:0001406)2.02293330
85Advanced eruption of teeth (HP:0006288)2.01886840
86Abnormal trabecular bone morphology (HP:0100671)2.00323650
87Hyperphosphatemia (HP:0002905)1.99779940
88Exocrine pancreatic insufficiency (HP:0001738)1.99639058
89Hypohidrosis (HP:0000966)1.99351726
90Pustule (HP:0200039)1.98939597
91Abnormality of chloride homeostasis (HP:0011422)1.97518533
92Dehydration (HP:0001944)1.97403478
93Abnormality of the nasal septum (HP:0000419)1.97151728
94Hypoglycemic coma (HP:0001325)1.95600562
95Neonatal death (HP:0003811)1.94904004
96Abnormal hair laboratory examination (HP:0003328)1.94544583
97Hypoplastic labia majora (HP:0000059)1.94176669
98Sensory axonal neuropathy (HP:0003390)1.92464077
99Late onset (HP:0003584)1.92293446
100Unilateral renal agenesis (HP:0000122)1.90923618
101Anhidrosis (HP:0000970)1.90763852
102Short nail (HP:0001799)1.90539993
103Xanthomatosis (HP:0000991)1.89946519
104Tetraparesis (HP:0002273)1.89329398
105Reticulocytopenia (HP:0001896)1.89086433
106Sparse scalp hair (HP:0002209)1.88970583
107Palmoplantar keratoderma (HP:0000982)1.87902047
108Ventricular fibrillation (HP:0001663)1.87819864
109Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86972321
11011 pairs of ribs (HP:0000878)1.86748071
111Insulin resistance (HP:0000855)1.85738640
112Congenital, generalized hypertrichosis (HP:0004540)1.85206937
113Pancreatic cysts (HP:0001737)1.84846665
114Delayed gross motor development (HP:0002194)1.84738622
115Esophageal varix (HP:0002040)1.84445343
116Interstitial pulmonary disease (HP:0006530)1.82957879
117Entropion (HP:0000621)1.82769582
118Selective tooth agenesis (HP:0001592)1.82176864
119Sparse lateral eyebrow (HP:0005338)1.81604761
120Hyperinsulinemic hypoglycemia (HP:0000825)1.81357344
121Tubulointerstitial nephritis (HP:0001970)1.81131691
122Pterygium (HP:0001059)1.80517859
123Hypolipoproteinemia (HP:0010981)1.80270730
124Ventricular tachycardia (HP:0004756)1.80063208
125Wide intermamillary distance (HP:0006610)1.79754181
126Focal segmental glomerulosclerosis (HP:0000097)1.79527064
127Stenosis of the external auditory canal (HP:0000402)1.78709894
128Ridged nail (HP:0001807)1.78033633
129Amniotic constriction ring (HP:0009775)1.78028156
130Abnormality of placental membranes (HP:0011409)1.78028156
131Abnormality of urine glucose concentration (HP:0011016)1.77202890
132Glycosuria (HP:0003076)1.77202890
133Hyperactive renin-angiotensin system (HP:0000841)1.76997730
134Fragile skin (HP:0001030)1.75067157
135Diminished movement (HP:0002374)1.74756268
136Proximal tubulopathy (HP:0000114)1.73990181
137Chorioretinal atrophy (HP:0000533)1.73522435
138Type II lissencephaly (HP:0007260)1.73116788
139Furrowed tongue (HP:0000221)1.72251071
140Absent eyebrow (HP:0002223)1.70312460
141Large for gestational age (HP:0001520)1.69152718
142Tongue fasciculations (HP:0001308)1.68171859
143Asymmetry of the thorax (HP:0001555)1.68162903
144Median cleft lip (HP:0000161)1.66220691
145Abnormality of secondary sexual hair (HP:0009888)1.66169551
146Abnormality of the axillary hair (HP:0100134)1.66169551
147Severe muscular hypotonia (HP:0006829)1.64709667
148Microretrognathia (HP:0000308)1.63928844
149Cutaneous melanoma (HP:0012056)1.63432463
150True hermaphroditism (HP:0010459)1.61399819
151Abnormality of the renal cortex (HP:0011035)1.59778689
152Blepharitis (HP:0000498)1.58255484
153Abnormality of dental color (HP:0011073)1.57693713
154Labial hypoplasia (HP:0000066)1.56491327
155Symptomatic seizures (HP:0011145)1.55513682
156Muscular hypotonia of the trunk (HP:0008936)1.54258237
157Disproportionate short-trunk short stature (HP:0003521)1.52716913
158Fibular aplasia (HP:0002990)1.52602794
159Hypoglycemic seizures (HP:0002173)1.50473643
160Cerebellar dysplasia (HP:0007033)1.49936420
161Duplicated collecting system (HP:0000081)1.47768091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.94143709
2TRIM283.48984913
3MAP3K33.46099107
4MAP3K123.36499215
5RPS6KB22.98394866
6MST42.87360680
7MST1R2.82825343
8MAPKAPK32.82583577
9CASK2.71779751
10FRK2.66494145
11TESK12.46156591
12EIF2AK12.30181654
13BCR2.27891923
14EIF2AK32.23480131
15LMTK22.09109592
16PIM22.06907832
17PTK62.05770022
18MAPK152.03197983
19STK242.03072749
20SIK32.01383360
21MAP3K21.96361983
22FER1.89968302
23STK391.74624776
24STK38L1.69266207
25STK101.51102704
26MAP2K21.47925640
27PIK3CG1.46645501
28NME21.46294655
29ERN11.46074013
30IRAK31.44834891
31PTK21.40562325
32RPS6KA41.38514567
33TRIB31.38414138
34WNK41.31021058
35EPHB21.30526263
36TRPM71.28516550
37MYLK1.28277544
38NEK91.26054738
39PASK1.25502728
40LATS11.22262708
41BRSK21.16012011
42LRRK21.15555126
43MAP2K31.15362624
44MAP3K111.12029215
45MUSK1.11423467
46PRKCI1.10736985
47DYRK31.08377328
48MAP3K91.06600189
49PAK31.02361245
50STK31.02308995
51FGFR21.01661367
52TAOK11.01250614
53BRSK11.01151085
54MET1.00307565
55PRKCE0.99467470
56TAF10.99252135
57CDK120.97456950
58CDK60.97451309
59DYRK1B0.96883296
60OXSR10.96339092
61STK380.95437193
62ERBB30.94864627
63LIMK10.89743115
64ACVR1B0.88862408
65AURKB0.88490761
66AKT30.88307885
67NEK20.87409729
68TTK0.87350713
69MAP3K10.87240536
70EPHA30.85219481
71MELK0.82698633
72TGFBR20.82555112
73MAP3K40.82333956
74RIPK10.80825215
75FGFR40.79931932
76WEE10.78739042
77MAP3K50.76629344
78MAP2K10.75474566
79BRAF0.75240376
80VRK20.74546547
81FLT30.71304349
82ZAK0.69941630
83CSNK1A1L0.68980748
84MAP4K20.67739740
85NME10.67130203
86LATS20.66702297
87MKNK20.66268338
88TAOK30.65833896
89CSNK1G10.64806688
90NLK0.64306154
91MAPKAPK20.64136849
92ILK0.64121276
93ERBB40.63300313
94BUB10.61885051
95MAP3K80.61878036
96CSNK1G30.61783052
97EPHB10.59210615
98KSR10.57462662
99MAP2K60.56393257
100PAK40.55931911
101EEF2K0.55147243
102TGFBR10.55140476
103AURKA0.54600788
104MAP2K70.53632136
105PIK3CA0.53444951
106ABL20.52621682
107FGFR10.51738901
108PRKG20.51202889
109PHKG10.51184179
110PHKG20.51184179
111CDK70.49186159
112TSSK60.46761800
113PBK0.46667446
114ARAF0.45942542
115CHUK0.45861225
116BRD40.45138894
117MOS0.44499070
118TEC0.44242756
119NEK10.44177239
120CSNK1G20.43958983
121CAMK2D0.41855660
122NUAK10.41681871
123ITK0.41216774
124PDK40.41133199
125PDK30.41133199
126PKN20.40958560
127YES10.40693883
128IRAK10.40392399
129BLK0.39331037
130GRK10.39290118
131PRKCG0.39213270
132DAPK10.38257754
133TBK10.38058080
134MINK10.36027126
135WNK30.35770818
136TAOK20.35521966
137ZAP700.34735128
138PLK20.34703460
139CAMK2G0.33738372
140GSK3A0.33068527
141BTK0.32983667
142ADRBK10.32489274
143EIF2AK20.32074298
144PDK20.31743415
145SRPK10.31721503
146STK160.31296735
147PIM10.31275838
148HIPK20.30599506
149ROCK10.29978530
150PRKAA10.29547868
151MTOR0.28900856
152CSNK1A10.27225196
153SCYL20.26981835
154PLK30.26893102
155IKBKB0.26702666
156PLK10.25251949
157PNCK0.24266194
158BMPR1B0.23787796
159INSRR0.23740274
160CHEK20.23456526

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.35609956
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.76662913
3Folate biosynthesis_Homo sapiens_hsa007902.50314001
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46115781
5Sulfur metabolism_Homo sapiens_hsa009202.41078954
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.39189900
7Ribosome_Homo sapiens_hsa030102.24603561
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22131518
9Glutathione metabolism_Homo sapiens_hsa004802.03384993
10Vitamin digestion and absorption_Homo sapiens_hsa049771.95691147
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91107598
12Arachidonic acid metabolism_Homo sapiens_hsa005901.90715028
13Vitamin B6 metabolism_Homo sapiens_hsa007501.89094640
14Bladder cancer_Homo sapiens_hsa052191.88618862
15Sphingolipid metabolism_Homo sapiens_hsa006001.85089061
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82200236
17Histidine metabolism_Homo sapiens_hsa003401.78155299
18p53 signaling pathway_Homo sapiens_hsa041151.70507982
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68448540
20Retinol metabolism_Homo sapiens_hsa008301.66673466
21Collecting duct acid secretion_Homo sapiens_hsa049661.66030411
22Chemical carcinogenesis_Homo sapiens_hsa052041.60989326
23Selenocompound metabolism_Homo sapiens_hsa004501.60670233
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59978012
25Caffeine metabolism_Homo sapiens_hsa002321.55834003
26Linoleic acid metabolism_Homo sapiens_hsa005911.55270667
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55127326
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54845840
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52997636
30Mineral absorption_Homo sapiens_hsa049781.52245757
31Fat digestion and absorption_Homo sapiens_hsa049751.51322482
32Butanoate metabolism_Homo sapiens_hsa006501.47754664
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44166635
34Proteasome_Homo sapiens_hsa030501.35773179
35Phenylalanine metabolism_Homo sapiens_hsa003601.33657420
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32195183
37Tight junction_Homo sapiens_hsa045301.31231392
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29614247
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27242738
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.22348425
41Galactose metabolism_Homo sapiens_hsa000521.22062134
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.19662095
43Hippo signaling pathway_Homo sapiens_hsa043901.19408850
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16302258
45Regulation of autophagy_Homo sapiens_hsa041401.16158678
46Adherens junction_Homo sapiens_hsa045201.15418872
47Small cell lung cancer_Homo sapiens_hsa052221.14093390
48Phototransduction_Homo sapiens_hsa047441.13757489
49Oxidative phosphorylation_Homo sapiens_hsa001901.12144499
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11319471
51RNA polymerase_Homo sapiens_hsa030201.09627412
52Starch and sucrose metabolism_Homo sapiens_hsa005001.08380562
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07010840
54Propanoate metabolism_Homo sapiens_hsa006401.03455200
55ABC transporters_Homo sapiens_hsa020100.98995047
56Synaptic vesicle cycle_Homo sapiens_hsa047210.93362920
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92346817
58Lysosome_Homo sapiens_hsa041420.91572022
59Pentose phosphate pathway_Homo sapiens_hsa000300.91042374
60Protein export_Homo sapiens_hsa030600.90850693
61beta-Alanine metabolism_Homo sapiens_hsa004100.90285494
62Renin-angiotensin system_Homo sapiens_hsa046140.89652361
63Other glycan degradation_Homo sapiens_hsa005110.89257156
64ECM-receptor interaction_Homo sapiens_hsa045120.88775552
65N-Glycan biosynthesis_Homo sapiens_hsa005100.86311088
66Fructose and mannose metabolism_Homo sapiens_hsa000510.85859381
67Steroid biosynthesis_Homo sapiens_hsa001000.85565998
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.83837286
69Pyrimidine metabolism_Homo sapiens_hsa002400.82816101
70RNA degradation_Homo sapiens_hsa030180.82654903
71Ether lipid metabolism_Homo sapiens_hsa005650.80169231
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79168974
73Tyrosine metabolism_Homo sapiens_hsa003500.77104107
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76161994
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.75489229
76Protein digestion and absorption_Homo sapiens_hsa049740.73721479
77Fatty acid degradation_Homo sapiens_hsa000710.73720029
78Hepatitis C_Homo sapiens_hsa051600.71851823
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71823627
80Thyroid cancer_Homo sapiens_hsa052160.71764327
81Basal cell carcinoma_Homo sapiens_hsa052170.71372976
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71341954
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71091385
84Tryptophan metabolism_Homo sapiens_hsa003800.70065111
85Peroxisome_Homo sapiens_hsa041460.68003971
86Nitrogen metabolism_Homo sapiens_hsa009100.66997231
87Fanconi anemia pathway_Homo sapiens_hsa034600.66707209
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64385384
89Glycerolipid metabolism_Homo sapiens_hsa005610.61672730
90RNA transport_Homo sapiens_hsa030130.61125869
91One carbon pool by folate_Homo sapiens_hsa006700.61053958
92Apoptosis_Homo sapiens_hsa042100.60964335
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.59432351
94AMPK signaling pathway_Homo sapiens_hsa041520.58289106
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58081232
96Homologous recombination_Homo sapiens_hsa034400.57615438
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56670615
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55315234
99Nucleotide excision repair_Homo sapiens_hsa034200.54826764
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54572159
101Sulfur relay system_Homo sapiens_hsa041220.53987539
102Circadian rhythm_Homo sapiens_hsa047100.53536219
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52876509
104Proteoglycans in cancer_Homo sapiens_hsa052050.52035478
105Prostate cancer_Homo sapiens_hsa052150.51501826
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.51204277
107Inositol phosphate metabolism_Homo sapiens_hsa005620.50735872
108Huntingtons disease_Homo sapiens_hsa050160.50551076
109Cell cycle_Homo sapiens_hsa041100.49516989
110Axon guidance_Homo sapiens_hsa043600.48500911
111Metabolic pathways_Homo sapiens_hsa011000.48205034
112Insulin secretion_Homo sapiens_hsa049110.47062536
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46073301
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44631081
115TGF-beta signaling pathway_Homo sapiens_hsa043500.44203993
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44073848
117Ovarian steroidogenesis_Homo sapiens_hsa049130.43279525
118Hedgehog signaling pathway_Homo sapiens_hsa043400.42239753
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41469857
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41142242
121Complement and coagulation cascades_Homo sapiens_hsa046100.40958896
122Toxoplasmosis_Homo sapiens_hsa051450.40191269
123Fatty acid elongation_Homo sapiens_hsa000620.39925183
124Oocyte meiosis_Homo sapiens_hsa041140.39232024
125Melanoma_Homo sapiens_hsa052180.38754404
126Arginine and proline metabolism_Homo sapiens_hsa003300.38692023
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35384271
128Pyruvate metabolism_Homo sapiens_hsa006200.35007770
129TNF signaling pathway_Homo sapiens_hsa046680.34898701
130Fatty acid metabolism_Homo sapiens_hsa012120.34799041
131Parkinsons disease_Homo sapiens_hsa050120.34593313
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.34486476
133Vibrio cholerae infection_Homo sapiens_hsa051100.34304544
134Amoebiasis_Homo sapiens_hsa051460.33464342
135Legionellosis_Homo sapiens_hsa051340.31948087
136HTLV-I infection_Homo sapiens_hsa051660.31081643
137Basal transcription factors_Homo sapiens_hsa030220.30299421
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29605113

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