TUBBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83034638
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.73635700
3ATP synthesis coupled proton transport (GO:0015986)4.73635700
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.39398517
5sequestering of actin monomers (GO:0042989)4.21610028
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.07196716
7NADH dehydrogenase complex assembly (GO:0010257)4.07196716
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07196716
9GTP biosynthetic process (GO:0006183)4.00046521
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97615873
11pyrimidine nucleobase catabolic process (GO:0006208)3.96707547
12protein complex biogenesis (GO:0070271)3.76670209
13proteasome assembly (GO:0043248)3.65010739
14mitochondrial respiratory chain complex assembly (GO:0033108)3.59530101
15DNA double-strand break processing (GO:0000729)3.58086608
16UTP biosynthetic process (GO:0006228)3.52433335
17chaperone-mediated protein transport (GO:0072321)3.52366230
18cullin deneddylation (GO:0010388)3.44582280
19respiratory electron transport chain (GO:0022904)3.40428127
20DNA damage response, detection of DNA damage (GO:0042769)3.39613984
21UTP metabolic process (GO:0046051)3.39364495
22electron transport chain (GO:0022900)3.38919504
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37253800
24chromatin remodeling at centromere (GO:0031055)3.36431601
25behavioral response to nicotine (GO:0035095)3.32753680
26protein deneddylation (GO:0000338)3.28816526
27protein neddylation (GO:0045116)3.28672962
28CENP-A containing nucleosome assembly (GO:0034080)3.27398577
29nucleobase catabolic process (GO:0046113)3.26978372
30spliceosomal snRNP assembly (GO:0000387)3.24156035
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19681023
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19681023
33ubiquinone metabolic process (GO:0006743)3.17367990
34guanosine-containing compound biosynthetic process (GO:1901070)3.17119564
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16414941
36regulation of mitochondrial translation (GO:0070129)3.15317829
37pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14379150
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13197791
39protein-cofactor linkage (GO:0018065)3.12553971
40CTP metabolic process (GO:0046036)3.12252824
41CTP biosynthetic process (GO:0006241)3.12252824
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10930013
43pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.09359010
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05009204
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02879872
46platelet dense granule organization (GO:0060155)2.97647777
47water-soluble vitamin biosynthetic process (GO:0042364)2.96091729
48DNA deamination (GO:0045006)2.92510183
49organelle disassembly (GO:1903008)2.91061546
50DNA replication checkpoint (GO:0000076)2.89919309
51pseudouridine synthesis (GO:0001522)2.89440602
52regulation of cellular amino acid metabolic process (GO:0006521)2.89414042
53DNA strand elongation involved in DNA replication (GO:0006271)2.88249051
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86403185
55DNA replication-dependent nucleosome assembly (GO:0006335)2.85713293
56DNA replication-dependent nucleosome organization (GO:0034723)2.85713293
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85662748
58replication fork processing (GO:0031297)2.84920203
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.82742950
60ubiquinone biosynthetic process (GO:0006744)2.82579639
61postreplication repair (GO:0006301)2.82004076
62isoprenoid biosynthetic process (GO:0008299)2.81464823
63negative regulation of ligase activity (GO:0051352)2.78963941
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78963941
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78536978
66pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.76781194
67DNA strand elongation (GO:0022616)2.76397150
68maturation of 5.8S rRNA (GO:0000460)2.76374133
69ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75585865
707-methylguanosine mRNA capping (GO:0006370)2.73635436
71signal transduction involved in cell cycle checkpoint (GO:0072395)2.73331193
72telomere maintenance via semi-conservative replication (GO:0032201)2.73322505
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73255230
74DNA catabolic process, exonucleolytic (GO:0000738)2.73244789
75positive regulation of mitochondrial fission (GO:0090141)2.73038530
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.72569738
77termination of RNA polymerase III transcription (GO:0006386)2.72569738
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72374155
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72374155
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72374155
81ATP biosynthetic process (GO:0006754)2.72195666
82regulation of double-strand break repair via homologous recombination (GO:0010569)2.70717600
83peptidyl-histidine modification (GO:0018202)2.68636858
84respiratory chain complex IV assembly (GO:0008535)2.68593090
85gamma-aminobutyric acid transport (GO:0015812)2.67233413
867-methylguanosine RNA capping (GO:0009452)2.66554726
87RNA capping (GO:0036260)2.66554726
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66503336
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66503336
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.65577427
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65577427
92de novo posttranslational protein folding (GO:0051084)2.64950998
93nucleoside diphosphate phosphorylation (GO:0006165)2.63343106
94nucleoside triphosphate biosynthetic process (GO:0009142)2.62599217
95inner mitochondrial membrane organization (GO:0007007)2.62004493
96de novo protein folding (GO:0006458)2.60827344
97translesion synthesis (GO:0019985)2.59276180
98amino acid salvage (GO:0043102)2.59018921
99L-methionine salvage (GO:0071267)2.59018921
100L-methionine biosynthetic process (GO:0071265)2.59018921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.72636834
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.98938699
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.64303310
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30784505
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29127932
6E2F7_22180533_ChIP-Seq_HELA_Human3.09425527
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04448853
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91477822
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.83499140
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76103912
11ZNF274_21170338_ChIP-Seq_K562_Hela2.67208525
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65837318
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52452728
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48013669
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44881482
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.41476995
17ELK1_19687146_ChIP-ChIP_HELA_Human2.40307097
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30358989
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28945591
20VDR_23849224_ChIP-Seq_CD4+_Human2.23206456
21VDR_22108803_ChIP-Seq_LS180_Human2.11051268
22IGF1R_20145208_ChIP-Seq_DFB_Human2.08504486
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07940567
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05239378
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04087769
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.99178661
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96960639
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96507221
29FOXP3_21729870_ChIP-Seq_TREG_Human1.85488924
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83865642
31MYC_18940864_ChIP-ChIP_HL60_Human1.83274564
32IRF1_19129219_ChIP-ChIP_H3396_Human1.82190494
33DCP1A_22483619_ChIP-Seq_HELA_Human1.77040986
34GABP_19822575_ChIP-Seq_HepG2_Human1.76851362
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75061252
36EWS_26573619_Chip-Seq_HEK293_Human1.69973294
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.69582601
38TTF2_22483619_ChIP-Seq_HELA_Human1.66712803
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63788788
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63030295
41XRN2_22483619_ChIP-Seq_HELA_Human1.59611829
42EZH2_22144423_ChIP-Seq_EOC_Human1.59111060
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55370174
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52481327
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51191933
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.49404893
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48386615
48FUS_26573619_Chip-Seq_HEK293_Human1.44752472
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44636631
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44503493
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44307635
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44011040
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40258116
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35264615
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34498229
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32127967
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30967263
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30886401
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29488600
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.27187496
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27128850
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26218659
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25740493
64TAF15_26573619_Chip-Seq_HEK293_Human1.21150877
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18610866
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.17143555
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.16709422
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15612315
69P300_19829295_ChIP-Seq_ESCs_Human1.14077733
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12244878
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10734568
72TP53_22573176_ChIP-Seq_HFKS_Human1.10694019
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10547247
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.08910252
75GBX2_23144817_ChIP-Seq_PC3_Human1.07607553
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07545670
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.06290964
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.05304844
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.04097502
80KDM5A_27292631_Chip-Seq_BREAST_Human1.01872271
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01509470
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00522536
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.00043358
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99851132
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98262016
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92105826
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91748181
88MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90933375
89RNF2_27304074_Chip-Seq_NSC_Mouse0.90342018
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88857181
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87542454
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87002887
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86782216
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82966844
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80986252
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80565569
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79000691
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78752203
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78614624
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78046703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.36894925
2MP0001529_abnormal_vocalization3.12603942
3MP0000372_irregular_coat_pigmentation2.64306082
4MP0006292_abnormal_olfactory_placode2.63434466
5MP0008058_abnormal_DNA_repair2.59076995
6MP0008789_abnormal_olfactory_epithelium2.49271444
7MP0005499_abnormal_olfactory_system2.27026631
8MP0005394_taste/olfaction_phenotype2.27026631
9MP0003880_abnormal_central_pattern2.21087661
10MP0003122_maternal_imprinting2.14562355
11MP0010094_abnormal_chromosome_stability2.12956873
12MP0003693_abnormal_embryo_hatching2.12780907
13MP0005084_abnormal_gallbladder_morpholo2.09121134
14MP0002653_abnormal_ependyma_morphology1.97690782
15MP0002234_abnormal_pharynx_morphology1.92907022
16MP0002938_white_spotting1.92117004
17MP0006276_abnormal_autonomic_nervous1.87776993
18MP0000566_synostosis1.83209909
19MP0004142_abnormal_muscle_tone1.79872113
20MP0003121_genomic_imprinting1.77640204
21MP0002736_abnormal_nociception_after1.74907530
22MP0000049_abnormal_middle_ear1.73497558
23MP0001984_abnormal_olfaction1.69082433
24MP0000778_abnormal_nervous_system1.68459738
25MP0006072_abnormal_retinal_apoptosis1.59802214
26MP0005187_abnormal_penis_morphology1.59229496
27MP0008995_early_reproductive_senescence1.58642590
28MP0001986_abnormal_taste_sensitivity1.58288798
29MP0005423_abnormal_somatic_nervous1.55776176
30MP0004957_abnormal_blastocyst_morpholog1.55752183
31MP0004133_heterotaxia1.52872129
32MP0003718_maternal_effect1.48866430
33MP0006035_abnormal_mitochondrial_morpho1.47973786
34MP0005551_abnormal_eye_electrophysiolog1.47323847
35MP0003786_premature_aging1.46079723
36MP0002822_catalepsy1.44931614
37MP0008875_abnormal_xenobiotic_pharmacok1.41452866
38MP0003011_delayed_dark_adaptation1.40597309
39MP0001293_anophthalmia1.40013343
40MP0009697_abnormal_copulation1.39907338
41MP0008932_abnormal_embryonic_tissue1.38006535
42MP0003111_abnormal_nucleus_morphology1.37041467
43MP0003937_abnormal_limbs/digits/tail_de1.36027976
44MP0003119_abnormal_digestive_system1.34708735
45MP0010030_abnormal_orbit_morphology1.33197316
46MP0005253_abnormal_eye_physiology1.33047420
47MP0009745_abnormal_behavioral_response1.32703253
48MP0008877_abnormal_DNA_methylation1.29745113
49MP0000631_abnormal_neuroendocrine_gland1.27282458
50MP0005645_abnormal_hypothalamus_physiol1.27031867
51MP0001968_abnormal_touch/_nociception1.21708130
52MP0002751_abnormal_autonomic_nervous1.20299762
53MP0003890_abnormal_embryonic-extraembry1.19598609
54MP0008872_abnormal_physiological_respon1.17688474
55MP0003077_abnormal_cell_cycle1.16242862
56MP0009046_muscle_twitch1.14697956
57MP0003938_abnormal_ear_development1.13651194
58MP0002557_abnormal_social/conspecific_i1.13026243
59MP0002233_abnormal_nose_morphology1.11927029
60MP0001905_abnormal_dopamine_level1.11212928
61MP0000647_abnormal_sebaceous_gland1.10461284
62MP0003806_abnormal_nucleotide_metabolis1.09568897
63MP0002735_abnormal_chemical_nociception1.07199661
64MP0002272_abnormal_nervous_system1.07158301
65MP0002210_abnormal_sex_determination1.05171170
66MP0002282_abnormal_trachea_morphology1.03758720
67MP0002572_abnormal_emotion/affect_behav1.03156676
68MP0004147_increased_porphyrin_level1.03002699
69MP0003315_abnormal_perineum_morphology1.00904127
70MP0003635_abnormal_synaptic_transmissio0.99279174
71MP0002752_abnormal_somatic_nervous0.98158761
72MP0000026_abnormal_inner_ear0.97040590
73MP0003136_yellow_coat_color0.96504185
74MP0002184_abnormal_innervation0.95773988
75MP0000537_abnormal_urethra_morphology0.95548691
76MP0001286_abnormal_eye_development0.95241322
77MP0001764_abnormal_homeostasis0.93276983
78MP0003698_abnormal_male_reproductive0.91823619
79MP0005195_abnormal_posterior_eye0.91634664
80MP0002638_abnormal_pupillary_reflex0.89951774
81MP0003186_abnormal_redox_activity0.88853203
82MP0000653_abnormal_sex_gland0.88630425
83MP0001929_abnormal_gametogenesis0.88415780
84MP0003567_abnormal_fetal_cardiomyocyte0.88338067
85MP0002734_abnormal_mechanical_nocicepti0.88195795
86MP0006036_abnormal_mitochondrial_physio0.85559828
87MP0004742_abnormal_vestibular_system0.84550118
88MP0005171_absent_coat_pigmentation0.84450402
89MP0002160_abnormal_reproductive_system0.83999065
90MP0003221_abnormal_cardiomyocyte_apopto0.83261076
91MP0005391_vision/eye_phenotype0.82412159
92MP0003755_abnormal_palate_morphology0.81582665
93MP0000579_abnormal_nail_morphology0.81129003
94MP0005389_reproductive_system_phenotype0.80260558
95MP0000955_abnormal_spinal_cord0.80247217
96MP0001919_abnormal_reproductive_system0.80047010
97MP0002064_seizures0.79986630
98MP0003861_abnormal_nervous_system0.79120398
99MP0001145_abnormal_male_reproductive0.79083027
100MP0004270_analgesia0.76668109

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.76159263
2Acute encephalopathy (HP:0006846)4.31271813
3Abnormal mitochondria in muscle tissue (HP:0008316)4.19518501
4Abnormality of the labia minora (HP:0012880)4.15723941
5Mitochondrial inheritance (HP:0001427)4.11642722
6Increased CSF lactate (HP:0002490)3.87986672
7Progressive macrocephaly (HP:0004481)3.77333730
8Hepatocellular necrosis (HP:0001404)3.49584941
9Increased hepatocellular lipid droplets (HP:0006565)3.46113601
10Lipid accumulation in hepatocytes (HP:0006561)3.32935291
11Hepatic necrosis (HP:0002605)3.14953493
12Cerebral edema (HP:0002181)3.03583847
13Pancreatic cysts (HP:0001737)3.02354283
143-Methylglutaconic aciduria (HP:0003535)2.99848961
15Pancreatic fibrosis (HP:0100732)2.98295450
16True hermaphroditism (HP:0010459)2.93745396
17Cortical dysplasia (HP:0002539)2.92629836
18Retinal dysplasia (HP:0007973)2.88266736
19Lissencephaly (HP:0001339)2.85260094
20Increased serum pyruvate (HP:0003542)2.80193997
21Molar tooth sign on MRI (HP:0002419)2.78079903
22Abnormality of midbrain morphology (HP:0002418)2.78079903
23Renal Fanconi syndrome (HP:0001994)2.72810662
24Increased serum lactate (HP:0002151)2.72716364
25Optic disc pallor (HP:0000543)2.57604369
26Nephronophthisis (HP:0000090)2.57133475
27Colon cancer (HP:0003003)2.54430406
28Hyperglycinemia (HP:0002154)2.52634704
29Lactic acidosis (HP:0003128)2.48695837
30Abnormality of glycolysis (HP:0004366)2.48444072
31Leukodystrophy (HP:0002415)2.40580243
32Type II lissencephaly (HP:0007260)2.35228271
33Medial flaring of the eyebrow (HP:0010747)2.32584008
34Patellar aplasia (HP:0006443)2.29462508
35Abnormality of the anterior horn cell (HP:0006802)2.27079252
36Degeneration of anterior horn cells (HP:0002398)2.27079252
37Aplasia/Hypoplasia of the brainstem (HP:0007362)2.27036831
38Hypoplasia of the brainstem (HP:0002365)2.27036831
39Respiratory failure (HP:0002878)2.21484296
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16721322
41Aplasia/Hypoplasia of the patella (HP:0006498)2.15781393
42Abnormality of alanine metabolism (HP:0010916)2.11708577
43Hyperalaninemia (HP:0003348)2.11708577
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11708577
45Meckel diverticulum (HP:0002245)2.11349374
46Abnormality of the ileum (HP:0001549)2.10916002
47Abnormal number of erythroid precursors (HP:0012131)2.10200898
48Pendular nystagmus (HP:0012043)2.09772807
49Pachygyria (HP:0001302)2.09404736
50Sclerocornea (HP:0000647)2.09098218
51Exercise intolerance (HP:0003546)2.09026519
52Congenital stationary night blindness (HP:0007642)2.07659736
53Inability to walk (HP:0002540)2.04559411
54Gait imbalance (HP:0002141)2.04454298
55Occipital encephalocele (HP:0002085)2.00194891
56Aplasia/Hypoplasia of the uvula (HP:0010293)1.99944114
57Lethargy (HP:0001254)1.99812001
58Methylmalonic acidemia (HP:0002912)1.99064008
59Cerebral hypomyelination (HP:0006808)1.98746258
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98200098
61Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98200098
62Exertional dyspnea (HP:0002875)1.97660544
63Abnormality of the renal medulla (HP:0100957)1.95037624
64CNS demyelination (HP:0007305)1.94701087
65Methylmalonic aciduria (HP:0012120)1.94419596
66Nephrogenic diabetes insipidus (HP:0009806)1.93839408
67Congenital primary aphakia (HP:0007707)1.93442981
68Opisthotonus (HP:0002179)1.86959755
69Anencephaly (HP:0002323)1.86426004
70Poor suck (HP:0002033)1.85685517
71Preaxial hand polydactyly (HP:0001177)1.84797825
72Hypoplastic pelvis (HP:0008839)1.80219251
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.79806092
74Polyphagia (HP:0002591)1.79572668
75Delayed CNS myelination (HP:0002188)1.79330297
76Birth length less than 3rd percentile (HP:0003561)1.79294787
77Increased intramyocellular lipid droplets (HP:0012240)1.77394697
78Abnormality of the pons (HP:0007361)1.76762357
79Cystic liver disease (HP:0006706)1.76594947
80X-linked dominant inheritance (HP:0001423)1.75636472
81Thyroid-stimulating hormone excess (HP:0002925)1.75284411
82Concave nail (HP:0001598)1.75200091
83Atrophy/Degeneration involving motor neurons (HP:0007373)1.74766811
84Type I transferrin isoform profile (HP:0003642)1.74392484
85Genital tract atresia (HP:0001827)1.74182799
86Optic nerve coloboma (HP:0000588)1.74065683
87Shoulder girdle muscle weakness (HP:0003547)1.73321862
88Abnormality of the metopic suture (HP:0005556)1.72196275
89Vaginal atresia (HP:0000148)1.72085622
90Postaxial foot polydactyly (HP:0001830)1.71444034
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70311231
92Respiratory difficulties (HP:0002880)1.69355855
93Abnormal biliary tract physiology (HP:0012439)1.68970877
94Bile duct proliferation (HP:0001408)1.68970877
95Abnormality of serum amino acid levels (HP:0003112)1.67127340
96Abnormal respiratory motile cilium morphology (HP:0005938)1.66145075
97Abnormal respiratory epithelium morphology (HP:0012253)1.66145075
98Dandy-Walker malformation (HP:0001305)1.65885055
99Microvesicular hepatic steatosis (HP:0001414)1.65657171
100Congenital, generalized hypertrichosis (HP:0004540)1.65007378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.39804700
2VRK23.31015327
3MAP4K23.00233500
4BUB12.90838083
5TRIM282.62174643
6VRK12.56542576
7WNK32.54965049
8CDC72.45359762
9MAP2K72.43952481
10SRPK12.38188346
11MAP3K42.31668020
12DYRK22.14110594
13MARK12.09401190
14NUAK12.09009516
15TLK12.06069615
16BCR2.03956622
17TSSK61.94926201
18BCKDK1.83238516
19CSNK1G31.78100173
20NEK11.71311821
21TAF11.70409984
22STK161.67010817
23PLK31.64316123
24PBK1.57389764
25CSNK1G21.57201655
26CSNK1A1L1.54399865
27CASK1.53976579
28CSNK1G11.50921629
29MAPK131.41972441
30PLK41.38055046
31DYRK31.29870916
32WEE11.25588794
33NME11.16848028
34ADRBK21.16596305
35PINK11.14686451
36WNK41.11472657
37PLK11.08934155
38CCNB11.06930972
39RPS6KA41.06295296
40GRK11.05374900
41ATR1.05025545
42PNCK1.04663731
43MINK11.00126915
44ERBB30.99315063
45TTK0.97711565
46PDK20.96623944
47AURKA0.95371678
48MKNK10.94519187
49EPHA40.94421218
50TNIK0.94317199
51RPS6KA50.94007291
52AURKB0.92900407
53PRKCG0.90536808
54BRSK20.89873177
55LIMK10.89390670
56PLK20.86671441
57MKNK20.85983992
58BMPR1B0.84561583
59INSRR0.80997670
60CHEK20.80589814
61TIE10.68456675
62OXSR10.63814936
63STK390.62725980
64TESK20.62648111
65MST40.60669785
66BRSK10.59717960
67DAPK10.58740031
68EIF2AK20.56809375
69UHMK10.56325171
70EPHA30.55565004
71PRKCE0.53106975
72PASK0.52810002
73NEK20.51484991
74CSNK1A10.49322433
75MAP2K40.48714765
76PAK30.48421685
77CSNK2A10.46296398
78CDK140.45624465
79TESK10.45088385
80ADRBK10.45076980
81MAPKAPK50.44384545
82CDK180.44129367
83PHKG10.42214756
84PHKG20.42214756
85ATM0.40331482
86DYRK1A0.39164908
87CSNK2A20.38675000
88CDK150.38103904
89CHEK10.37617980
90CDK190.37204995
91DAPK30.36873652
92CDK80.36704881
93DYRK1B0.36294898
94EIF2AK10.36087517
95GRK50.35971479
96CDK11A0.35905480
97PKN10.35023683
98PAK60.33402145
99CSNK1E0.31330832
100EIF2AK30.31253285

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.50820506
2Oxidative phosphorylation_Homo sapiens_hsa001903.50036376
3Parkinsons disease_Homo sapiens_hsa050123.15006110
4RNA polymerase_Homo sapiens_hsa030202.57100651
5Protein export_Homo sapiens_hsa030602.56272987
6DNA replication_Homo sapiens_hsa030302.50373053
7Mismatch repair_Homo sapiens_hsa034302.36852830
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35144469
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33957993
10Huntingtons disease_Homo sapiens_hsa050162.27945668
11Homologous recombination_Homo sapiens_hsa034402.03807904
12Ribosome_Homo sapiens_hsa030102.02932179
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98697147
14Alzheimers disease_Homo sapiens_hsa050101.97226184
15Base excision repair_Homo sapiens_hsa034101.91931843
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88813595
17Steroid biosynthesis_Homo sapiens_hsa001001.88583977
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88192728
19Spliceosome_Homo sapiens_hsa030401.85642489
20Basal transcription factors_Homo sapiens_hsa030221.83463849
21Fanconi anemia pathway_Homo sapiens_hsa034601.81607506
22Nucleotide excision repair_Homo sapiens_hsa034201.63945306
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63255648
24Pyrimidine metabolism_Homo sapiens_hsa002401.58485401
25Sulfur relay system_Homo sapiens_hsa041221.50905743
26Butanoate metabolism_Homo sapiens_hsa006501.47329624
27RNA degradation_Homo sapiens_hsa030181.47083401
28RNA transport_Homo sapiens_hsa030131.44785986
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42512131
30Non-homologous end-joining_Homo sapiens_hsa034501.39416118
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39159055
32Nitrogen metabolism_Homo sapiens_hsa009101.38951581
33Fatty acid elongation_Homo sapiens_hsa000621.33222866
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32968781
35Cardiac muscle contraction_Homo sapiens_hsa042601.31737533
36Propanoate metabolism_Homo sapiens_hsa006401.27681453
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24679067
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24216850
39Nicotine addiction_Homo sapiens_hsa050331.18701182
40Phototransduction_Homo sapiens_hsa047441.18371171
41Purine metabolism_Homo sapiens_hsa002301.17641530
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16822490
43Alcoholism_Homo sapiens_hsa050341.14395870
44One carbon pool by folate_Homo sapiens_hsa006701.14329200
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13606071
46Systemic lupus erythematosus_Homo sapiens_hsa053221.12042398
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04680236
48Selenocompound metabolism_Homo sapiens_hsa004500.99052784
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.98483530
50Folate biosynthesis_Homo sapiens_hsa007900.94214637
51Peroxisome_Homo sapiens_hsa041460.91449299
52Sulfur metabolism_Homo sapiens_hsa009200.91335769
53Biosynthesis of amino acids_Homo sapiens_hsa012300.89074230
54Pyruvate metabolism_Homo sapiens_hsa006200.88024179
55Carbon metabolism_Homo sapiens_hsa012000.86014097
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85062339
57Tryptophan metabolism_Homo sapiens_hsa003800.84432225
58Linoleic acid metabolism_Homo sapiens_hsa005910.83452020
59Cell cycle_Homo sapiens_hsa041100.82913018
60Metabolic pathways_Homo sapiens_hsa011000.80280144
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75770104
62Glutathione metabolism_Homo sapiens_hsa004800.72833881
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71374761
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68732732
65Arginine biosynthesis_Homo sapiens_hsa002200.67253234
66Caffeine metabolism_Homo sapiens_hsa002320.66234012
67GABAergic synapse_Homo sapiens_hsa047270.63728657
68Collecting duct acid secretion_Homo sapiens_hsa049660.63539885
69Ether lipid metabolism_Homo sapiens_hsa005650.62542906
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62452360
71Fatty acid metabolism_Homo sapiens_hsa012120.55995308
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55848620
73Fat digestion and absorption_Homo sapiens_hsa049750.55800084
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55490226
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53164898
76mRNA surveillance pathway_Homo sapiens_hsa030150.50351717
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.49618987
78Oocyte meiosis_Homo sapiens_hsa041140.48965340
79Basal cell carcinoma_Homo sapiens_hsa052170.48594579
80N-Glycan biosynthesis_Homo sapiens_hsa005100.46208126
81Morphine addiction_Homo sapiens_hsa050320.45399840
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43727956
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42470900
84beta-Alanine metabolism_Homo sapiens_hsa004100.40848094
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39391067
86Fatty acid degradation_Homo sapiens_hsa000710.38981523
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37813227
88Arginine and proline metabolism_Homo sapiens_hsa003300.36150633
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35050853
90Olfactory transduction_Homo sapiens_hsa047400.34342095
91Chemical carcinogenesis_Homo sapiens_hsa052040.33976354
92Taste transduction_Homo sapiens_hsa047420.31717043
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31050970
94Hedgehog signaling pathway_Homo sapiens_hsa043400.31039204
95Vibrio cholerae infection_Homo sapiens_hsa051100.30742440
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29158529
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28570317
98p53 signaling pathway_Homo sapiens_hsa041150.27454358
99Cocaine addiction_Homo sapiens_hsa050300.26910645
100Regulation of autophagy_Homo sapiens_hsa041400.26474507

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