TUBB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.63927774
2establishment of integrated proviral latency (GO:0075713)5.20164180
3mitotic sister chromatid segregation (GO:0000070)4.93168166
4sister chromatid segregation (GO:0000819)4.77903413
5mitotic chromosome condensation (GO:0007076)4.63197890
6protein localization to kinetochore (GO:0034501)4.61423547
7DNA strand elongation involved in DNA replication (GO:0006271)4.49463688
8protein localization to chromosome, centromeric region (GO:0071459)4.45282490
9DNA strand elongation (GO:0022616)4.37168878
10nuclear pore complex assembly (GO:0051292)4.36287635
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.23805899
12establishment of viral latency (GO:0019043)4.07804048
13mitotic metaphase plate congression (GO:0007080)4.05916938
14nuclear pore organization (GO:0006999)3.97710838
15telomere maintenance via semi-conservative replication (GO:0032201)3.89703374
16DNA topological change (GO:0006265)3.84591153
17heterochromatin organization (GO:0070828)3.64241500
18DNA replication initiation (GO:0006270)3.62913942
19DNA ligation (GO:0006266)3.61494893
20microtubule depolymerization (GO:0007019)3.50337860
21metaphase plate congression (GO:0051310)3.49197617
22mitotic sister chromatid cohesion (GO:0007064)3.48448851
23peptidyl-arginine omega-N-methylation (GO:0035247)3.47834223
24mitotic nuclear envelope disassembly (GO:0007077)3.39190119
25chromatin remodeling at centromere (GO:0031055)3.36404389
26CENP-A containing nucleosome assembly (GO:0034080)3.33635777
27ATP-dependent chromatin remodeling (GO:0043044)3.29049522
28protein localization to chromosome (GO:0034502)3.28169600
29protein-DNA complex disassembly (GO:0032986)3.27529817
30nucleosome disassembly (GO:0006337)3.27529817
31mitotic recombination (GO:0006312)3.23697711
32membrane disassembly (GO:0030397)3.22779604
33nuclear envelope disassembly (GO:0051081)3.22779604
34L-serine metabolic process (GO:0006563)3.22520382
35paraxial mesoderm development (GO:0048339)3.22477680
36regulation of sister chromatid cohesion (GO:0007063)3.20522931
37pore complex assembly (GO:0046931)3.18527642
38regulation of chromosome segregation (GO:0051983)3.18057828
39histone arginine methylation (GO:0034969)3.17208675
40chromosome condensation (GO:0030261)3.16157669
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15863334
42telomere maintenance via recombination (GO:0000722)3.14738601
43DNA replication-independent nucleosome assembly (GO:0006336)3.11537344
44DNA replication-independent nucleosome organization (GO:0034724)3.11537344
45peptidyl-arginine N-methylation (GO:0035246)3.08380462
46peptidyl-arginine methylation (GO:0018216)3.08380462
47spindle checkpoint (GO:0031577)3.08368731
48regulation of spindle organization (GO:0090224)3.08266826
49DNA replication checkpoint (GO:0000076)3.07275762
50establishment of chromosome localization (GO:0051303)3.06679332
51non-recombinational repair (GO:0000726)3.05584684
52double-strand break repair via nonhomologous end joining (GO:0006303)3.05584684
53negative regulation of chromosome segregation (GO:0051985)3.04851433
54chromosome segregation (GO:0007059)3.02356710
55pyrimidine nucleobase catabolic process (GO:0006208)3.00454406
56protein complex localization (GO:0031503)2.98862139
57positive regulation of chromosome segregation (GO:0051984)2.95884397
58mitotic spindle organization (GO:0007052)2.95392612
59kinetochore organization (GO:0051383)2.95298944
60nucleotide-excision repair, DNA gap filling (GO:0006297)2.92667197
61mitotic spindle checkpoint (GO:0071174)2.92587995
62DNA duplex unwinding (GO:0032508)2.92279790
63IMP biosynthetic process (GO:0006188)2.92275906
64regulation of mitotic spindle organization (GO:0060236)2.92104856
65negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92048446
66negative regulation of mitotic sister chromatid separation (GO:2000816)2.92048446
67negative regulation of sister chromatid segregation (GO:0033046)2.92048446
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92048446
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92048446
70mitotic spindle assembly checkpoint (GO:0007094)2.85181674
71regulation of translational fidelity (GO:0006450)2.84030250
72DNA geometric change (GO:0032392)2.83141385
73spliceosomal tri-snRNP complex assembly (GO:0000244)2.82195933
74DNA replication-dependent nucleosome assembly (GO:0006335)2.81207930
75DNA replication-dependent nucleosome organization (GO:0034723)2.81207930
76negative regulation of mRNA processing (GO:0050686)2.80879708
77spindle assembly checkpoint (GO:0071173)2.80676621
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77608869
79chromatin assembly or disassembly (GO:0006333)2.76781202
80pre-miRNA processing (GO:0031054)2.75914506
81DNA conformation change (GO:0071103)2.72469509
82DNA damage response, detection of DNA damage (GO:0042769)2.72352573
83base-excision repair (GO:0006284)2.71847795
84de novo posttranslational protein folding (GO:0051084)2.71293040
85regulation of mitotic sister chromatid separation (GO:0010965)2.71150878
86regulation of mitotic sister chromatid segregation (GO:0033047)2.71150878
87regulation of sister chromatid segregation (GO:0033045)2.71150878
88regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70138947
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70138947
90DNA packaging (GO:0006323)2.69997569
91histone exchange (GO:0043486)2.69165080
92de novo protein folding (GO:0006458)2.68328206
93formation of translation preinitiation complex (GO:0001731)2.66718061
94telomere maintenance via telomere lengthening (GO:0010833)2.65451620
95DNA strand renaturation (GO:0000733)2.62010344
96* mitotic cell cycle (GO:0000278)2.61558097
97nuclear envelope organization (GO:0006998)2.60992912
98negative regulation of microtubule polymerization (GO:0031115)2.57825171
99V(D)J recombination (GO:0033151)2.54698642
100chromatin assembly (GO:0031497)2.53964016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99493420
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.82376453
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01110065
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80077161
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.70133629
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.24411563
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03098343
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02060443
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65320232
10AR_21909140_ChIP-Seq_LNCAP_Human2.64275031
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54598268
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47441054
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37257365
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33228763
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33212835
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32436326
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30858956
18* XRN2_22483619_ChIP-Seq_HELA_Human2.24872452
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21693375
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.17934127
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.13439708
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06530138
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00731446
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99878736
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94384051
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93709930
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90687481
28TTF2_22483619_ChIP-Seq_HELA_Human1.85090865
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83958856
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.80734391
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79279813
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79150999
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78705839
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76379246
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.76378560
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74712635
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71554421
38DCP1A_22483619_ChIP-Seq_HELA_Human1.70871415
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70620105
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68093550
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66473301
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64240586
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61902068
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.56167669
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.48744696
46GABP_19822575_ChIP-Seq_HepG2_Human1.48249980
47* SOX2_16153702_ChIP-ChIP_HESCs_Human1.47108336
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40474231
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.40008064
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39104467
51* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38179306
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37469056
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.34061904
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32475491
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.29444710
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28565907
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27441285
58ELK1_19687146_ChIP-ChIP_HELA_Human1.25408668
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.24895579
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24700320
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19565162
62KDM5A_27292631_Chip-Seq_BREAST_Human1.17515125
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15381742
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15067224
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13709140
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13578246
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13085538
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12719091
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12300391
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11458333
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11420088
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.10028510
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09454370
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.09443929
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07754744
76FOXP3_21729870_ChIP-Seq_TREG_Human1.06278011
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04883793
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04758432
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02957416
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.02243339
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00054717
82CIITA_25753668_ChIP-Seq_RAJI_Human0.99787914
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99593404
84MYC_18940864_ChIP-ChIP_HL60_Human0.94936634
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94796263
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94500679
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94487110
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90832328
89SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88297747
90* MYC_22102868_ChIP-Seq_BL_Human0.87836280
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87771540
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87139365
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86867489
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85809959
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84106585
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82540909
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.82518680
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81450434
99VDR_23849224_ChIP-Seq_CD4+_Human0.80017837
100CLOCK_20551151_ChIP-Seq_293T_Human0.79440613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.65763293
2MP0003693_abnormal_embryo_hatching3.62928241
3MP0003111_abnormal_nucleus_morphology3.52769354
4MP0004957_abnormal_blastocyst_morpholog2.95424145
5MP0003077_abnormal_cell_cycle2.86349477
6MP0008932_abnormal_embryonic_tissue2.82894353
7MP0010030_abnormal_orbit_morphology2.52088940
8MP0008058_abnormal_DNA_repair2.44011902
9MP0008057_abnormal_DNA_replication2.12119462
10MP0001529_abnormal_vocalization2.08343157
11MP0000537_abnormal_urethra_morphology1.95318503
12MP0001730_embryonic_growth_arrest1.94792300
13MP0000566_synostosis1.94525526
14MP0003890_abnormal_embryonic-extraembry1.92926508
15MP0009672_abnormal_birth_weight1.85764456
16MP0006292_abnormal_olfactory_placode1.81675281
17MP0000778_abnormal_nervous_system1.80526411
18MP0008007_abnormal_cellular_replicative1.78862186
19MP0003937_abnormal_limbs/digits/tail_de1.73501300
20MP0005499_abnormal_olfactory_system1.69335414
21MP0005394_taste/olfaction_phenotype1.69335414
22MP0002085_abnormal_embryonic_tissue1.68533557
23MP0002697_abnormal_eye_size1.67551030
24MP0001293_anophthalmia1.66783748
25MP0000350_abnormal_cell_proliferation1.65316676
26MP0005380_embryogenesis_phenotype1.58072928
27MP0001672_abnormal_embryogenesis/_devel1.58072928
28MP0003122_maternal_imprinting1.57521337
29MP0002084_abnormal_developmental_patter1.55681481
30MP0003861_abnormal_nervous_system1.55559805
31MP0000049_abnormal_middle_ear1.51843125
32MP0003315_abnormal_perineum_morphology1.48919951
33MP0001299_abnormal_eye_distance/1.47442108
34MP0008789_abnormal_olfactory_epithelium1.46945420
35MP0001697_abnormal_embryo_size1.44992700
36MP0003385_abnormal_body_wall1.43337557
37MP0004197_abnormal_fetal_growth/weight/1.41281656
38MP0009697_abnormal_copulation1.40974253
39MP0003121_genomic_imprinting1.39984166
40MP0002080_prenatal_lethality1.39732561
41MP0001286_abnormal_eye_development1.39563558
42MP0003567_abnormal_fetal_cardiomyocyte1.38608651
43MP0003119_abnormal_digestive_system1.37997829
44MP0002938_white_spotting1.36723807
45MP0005623_abnormal_meninges_morphology1.35788719
46MP0003984_embryonic_growth_retardation1.34751693
47MP0001346_abnormal_lacrimal_gland1.32616136
48MP0005257_abnormal_intraocular_pressure1.29888057
49MP0002088_abnormal_embryonic_growth/wei1.29376823
50MP0002233_abnormal_nose_morphology1.28222164
51MP0003942_abnormal_urinary_system1.27617261
52MP0002751_abnormal_autonomic_nervous1.22545626
53MP0003705_abnormal_hypodermis_morpholog1.21760691
54MP0003755_abnormal_palate_morphology1.20042836
55MP0003941_abnormal_skin_development1.17766447
56MP0002092_abnormal_eye_morphology1.14810214
57MP0000428_abnormal_craniofacial_morphol1.14131071
58MP0000534_abnormal_ureter_morphology1.13393735
59MP0003718_maternal_effect1.11637236
60MP0003115_abnormal_respiratory_system1.10914333
61MP0002111_abnormal_tail_morphology1.10867195
62MP0009703_decreased_birth_body1.09898242
63MP0003935_abnormal_craniofacial_develop1.06922212
64MP0002081_perinatal_lethality1.06404795
65MP0003221_abnormal_cardiomyocyte_apopto1.05350685
66MP0010352_gastrointestinal_tract_polyps1.05306591
67MP0009053_abnormal_anal_canal1.04391720
68MP0002822_catalepsy1.03230792
69MP0003938_abnormal_ear_development0.98768031
70MP0004811_abnormal_neuron_physiology0.97310233
71MP0003880_abnormal_central_pattern0.97085724
72MP0005187_abnormal_penis_morphology0.96833935
73MP0004272_abnormal_basement_membrane0.96147501
74MP0002152_abnormal_brain_morphology0.94203038
75MP0003123_paternal_imprinting0.92933774
76MP0002184_abnormal_innervation0.91952374
77MP0000313_abnormal_cell_death0.91892509
78MP0002086_abnormal_extraembryonic_tissu0.91856068
79MP0002102_abnormal_ear_morphology0.91830347
80MP0004133_heterotaxia0.91424526
81MP0002234_abnormal_pharynx_morphology0.87434935
82MP0004233_abnormal_muscle_weight0.85217348
83MP0000647_abnormal_sebaceous_gland0.85045376
84MP0000955_abnormal_spinal_cord0.84831812
85MP0004270_analgesia0.84718934
86MP0002116_abnormal_craniofacial_bone0.84258118
87MP0004859_abnormal_synaptic_plasticity0.83987785
88MP0001188_hyperpigmentation0.82302128
89MP0000432_abnormal_head_morphology0.81541195
90MP0001849_ear_inflammation0.80494220
91MP0005076_abnormal_cell_differentiation0.80390251
92MP0002210_abnormal_sex_determination0.77523891
93MP0003786_premature_aging0.77123333
94MP0008877_abnormal_DNA_methylation0.77029709
95MP0000751_myopathy0.76476132
96MP0000579_abnormal_nail_morphology0.76035591
97MP0005391_vision/eye_phenotype0.74495593
98MP0002114_abnormal_axial_skeleton0.74408428
99MP0002249_abnormal_larynx_morphology0.74019706
100MP0000358_abnormal_cell_content/0.70886077

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70284446
2Increased nuchal translucency (HP:0010880)3.33719315
3Chromsome breakage (HP:0040012)3.25852570
4High anterior hairline (HP:0009890)3.04655941
5Abnormality of the labia minora (HP:0012880)2.86524793
6* Cortical dysplasia (HP:0002539)2.82854927
7Abnormal lung lobation (HP:0002101)2.68871756
8Meckel diverticulum (HP:0002245)2.63731691
9Trigonocephaly (HP:0000243)2.50218882
10Shoulder girdle muscle weakness (HP:0003547)2.49298239
11Abnormality of the ileum (HP:0001549)2.47890359
12Proximal placement of thumb (HP:0009623)2.40806130
13Hyperacusis (HP:0010780)2.35414487
14Insomnia (HP:0100785)2.32537452
15Deviation of the thumb (HP:0009603)2.28241751
16Medulloblastoma (HP:0002885)2.27972022
17Colon cancer (HP:0003003)2.26493266
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.26470228
19Birth length less than 3rd percentile (HP:0003561)2.23043891
20Patellar aplasia (HP:0006443)2.19019910
21Nephroblastoma (Wilms tumor) (HP:0002667)2.18143730
22Abnormality of glycolysis (HP:0004366)2.18054329
23Generalized hypotonia (HP:0001290)2.17117158
24Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08376152
25Overriding aorta (HP:0002623)2.08308850
26Ependymoma (HP:0002888)2.08220079
27Small intestinal stenosis (HP:0012848)2.08092647
28Duodenal stenosis (HP:0100867)2.08092647
29Hypoplastic pelvis (HP:0008839)2.06445175
30Abnormality of the carotid arteries (HP:0005344)2.05200014
31Embryonal renal neoplasm (HP:0011794)2.04032101
32Absent epiphyses (HP:0010577)2.03699327
33Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03699327
34Aplasia/Hypoplasia of the patella (HP:0006498)1.98491349
35Absent radius (HP:0003974)1.98418461
36Renal duplication (HP:0000075)1.96828194
37Aplasia/Hypoplasia of the sternum (HP:0006714)1.95366099
38Abnormality of the musculature of the pelvis (HP:0001469)1.95143530
39Abnormality of the hip-girdle musculature (HP:0001445)1.95143530
40Broad distal phalanx of finger (HP:0009836)1.93122171
41Spastic diplegia (HP:0001264)1.92829063
42Abnormality of the metopic suture (HP:0005556)1.92177069
43Abnormality of the duodenum (HP:0002246)1.91360470
44Abnormal number of incisors (HP:0011064)1.90719722
45Hepatoblastoma (HP:0002884)1.90440802
46Aplasia involving forearm bones (HP:0009822)1.90332886
47Absent forearm bone (HP:0003953)1.90332886
48Pelvic girdle muscle weakness (HP:0003749)1.89996641
49Overlapping toe (HP:0001845)1.89075454
50Horseshoe kidney (HP:0000085)1.88655123
51Abnormality of the preputium (HP:0100587)1.87039601
52Abnormality of the calcaneus (HP:0008364)1.84987238
53Selective tooth agenesis (HP:0001592)1.84843925
54Abnormality of chromosome stability (HP:0003220)1.84018223
55Increased serum pyruvate (HP:0003542)1.82055464
56Prominent metopic ridge (HP:0005487)1.80933367
57Reticulocytopenia (HP:0001896)1.79015090
58Ectopic kidney (HP:0000086)1.78828190
59Lissencephaly (HP:0001339)1.77915966
60Elfin facies (HP:0004428)1.76853496
61Abnormal gallbladder physiology (HP:0012438)1.73991920
62Cholecystitis (HP:0001082)1.73991920
63Duplication of thumb phalanx (HP:0009942)1.73766531
64Myelomeningocele (HP:0002475)1.70982323
65Facial hemangioma (HP:0000329)1.70116327
66Pointed chin (HP:0000307)1.68519230
67Hemivertebrae (HP:0002937)1.67395453
68Termporal pattern (HP:0011008)1.66639741
69Insidious onset (HP:0003587)1.66639741
70Facial cleft (HP:0002006)1.65663486
71Heterotopia (HP:0002282)1.65544389
72Abnormality of the lower motor neuron (HP:0002366)1.65238570
73Astrocytoma (HP:0009592)1.64896956
74Abnormality of the astrocytes (HP:0100707)1.64896956
75Shallow orbits (HP:0000586)1.64714483
76Short 4th metacarpal (HP:0010044)1.64655629
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64655629
78Leiomyosarcoma (HP:0100243)1.63268679
79Uterine leiomyosarcoma (HP:0002891)1.63268679
80Atresia of the external auditory canal (HP:0000413)1.63257875
81Optic nerve coloboma (HP:0000588)1.63024865
82Volvulus (HP:0002580)1.61074868
83Bilateral microphthalmos (HP:0007633)1.60385606
84Long palpebral fissure (HP:0000637)1.60384517
85Aplasia/Hypoplasia of the breasts (HP:0010311)1.60116162
86Spina bifida occulta (HP:0003298)1.59033957
87Triphalangeal thumb (HP:0001199)1.56546786
88Glioma (HP:0009733)1.56208284
89Abnormality of abdominal situs (HP:0011620)1.56035501
90Abdominal situs inversus (HP:0003363)1.56035501
91Breast hypoplasia (HP:0003187)1.55970450
92Microglossia (HP:0000171)1.54505078
93Microvesicular hepatic steatosis (HP:0001414)1.54146596
94Upper limb muscle weakness (HP:0003484)1.53554560
95Obsessive-compulsive behavior (HP:0000722)1.52912755
96Abnormality of the septum pellucidum (HP:0007375)1.52558330
97Choanal atresia (HP:0000453)1.51954434
98Glossoptosis (HP:0000162)1.51773406
99Multiple enchondromatosis (HP:0005701)1.50743698
100Skull defect (HP:0001362)1.50213139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.23920286
2SRPK13.27540576
3CDC73.20394457
4TTK3.04058986
5TSSK62.76093806
6NEK12.49377917
7WEE12.42446742
8VRK22.42437728
9MAP3K102.19201614
10MARK12.13121938
11PLK41.97393213
12BCR1.91035274
13TRIM281.83678301
14PLK31.80778655
15PBK1.75650039
16MKNK11.75370970
17SMG11.70880162
18DYRK21.68029445
19BRSK11.62353125
20ICK1.59896580
21CHEK21.55434122
22TAF11.51872018
23PLK11.47080825
24NEK21.45483834
25PNCK1.36105994
26MAP2K71.30030039
27ATR1.24747515
28BRSK21.23611339
29AURKB1.22206826
30CDK71.19525475
31DYRK31.18472858
32PASK1.16474122
33MKNK21.15081877
34EIF2AK11.11711169
35CDK181.11402428
36PAK41.08764473
37CDK151.07820205
38AURKA1.07157669
39VRK11.06943637
40CDK11A1.06182589
41MAP3K41.05291857
42EEF2K1.05110110
43CDK141.04813227
44CSNK1G31.02489978
45CHEK11.01328334
46CCNB11.00366049
47LATS20.98471828
48CASK0.95726909
49LIMK10.95526146
50EPHB20.95271381
51CDK120.94752374
52ZAK0.94336913
53CSNK1A1L0.92677435
54MINK10.91882797
55RPS6KA40.89575480
56UHMK10.89330364
57CDK80.89020441
58PDGFRA0.88525623
59CLK10.84613270
60TESK20.82933893
61CSNK1G20.82685971
62CSNK1G10.82634948
63TESK10.79829269
64ERBB40.78948245
65WNK30.77345910
66ATM0.76819100
67KSR10.73939104
68CDK10.73317329
69NTRK10.70159367
70MAP3K80.69209513
71BRD40.67443604
72EIF2AK20.65956318
73CDK20.65845362
74LATS10.64679806
75CDK40.64265613
76STK40.61109983
77CDK190.58047039
78TYRO30.55402485
79BRAF0.55271811
80PRKD30.50814758
81ALK0.49606138
82SCYL20.47766173
83MAP4K20.46972114
84EPHA20.46631738
85PRKDC0.46424285
86SIK30.46213394
87DAPK10.45937464
88PTK20.45710712
89CDK60.44923797
90FGFR10.44426476
91CSNK1E0.43695448
92PAK20.42830969
93CAMK1G0.40249876
94SIK20.37682877
95MTOR0.37195145
96TNIK0.37152319
97PAK10.36215894
98AKT20.36176880
99NTRK20.35578526
100CDK90.35216070

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.41017845
2Mismatch repair_Homo sapiens_hsa034303.47178892
3Base excision repair_Homo sapiens_hsa034102.98383447
4Cell cycle_Homo sapiens_hsa041102.85521822
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78318414
6Non-homologous end-joining_Homo sapiens_hsa034502.71135980
7Spliceosome_Homo sapiens_hsa030402.58916637
8RNA transport_Homo sapiens_hsa030132.27015575
9Biosynthesis of amino acids_Homo sapiens_hsa012302.11654850
10Nucleotide excision repair_Homo sapiens_hsa034202.09628865
11Fanconi anemia pathway_Homo sapiens_hsa034602.00355066
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93861722
13Homologous recombination_Homo sapiens_hsa034401.87138060
14Proteasome_Homo sapiens_hsa030501.85278648
15Steroid biosynthesis_Homo sapiens_hsa001001.85131026
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82822776
17mRNA surveillance pathway_Homo sapiens_hsa030151.77775596
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76347999
19One carbon pool by folate_Homo sapiens_hsa006701.63367553
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52182790
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48359212
22Pyrimidine metabolism_Homo sapiens_hsa002401.44699709
23Carbon metabolism_Homo sapiens_hsa012001.36343026
24Oocyte meiosis_Homo sapiens_hsa041141.31825577
25Basal cell carcinoma_Homo sapiens_hsa052171.30926166
26* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30146149
27RNA polymerase_Homo sapiens_hsa030201.28291288
28Hippo signaling pathway_Homo sapiens_hsa043901.25116126
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.22922386
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20219166
31Basal transcription factors_Homo sapiens_hsa030221.17023567
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.16035374
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10863319
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09891971
35Pyruvate metabolism_Homo sapiens_hsa006201.08545834
36Adherens junction_Homo sapiens_hsa045201.04298116
37Fatty acid elongation_Homo sapiens_hsa000621.02336452
38Pentose phosphate pathway_Homo sapiens_hsa000301.01886548
39RNA degradation_Homo sapiens_hsa030181.00679355
40Lysine degradation_Homo sapiens_hsa003101.00100062
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99541906
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98944773
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98019353
44Axon guidance_Homo sapiens_hsa043600.96221716
45Vitamin B6 metabolism_Homo sapiens_hsa007500.95358850
46MicroRNAs in cancer_Homo sapiens_hsa052060.95154951
47Colorectal cancer_Homo sapiens_hsa052100.91795835
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91076359
49Selenocompound metabolism_Homo sapiens_hsa004500.89730597
50p53 signaling pathway_Homo sapiens_hsa041150.89465426
51Hedgehog signaling pathway_Homo sapiens_hsa043400.89017003
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88959394
53Wnt signaling pathway_Homo sapiens_hsa043100.88387789
54Thyroid cancer_Homo sapiens_hsa052160.81140826
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78360293
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77727988
57Ribosome_Homo sapiens_hsa030100.77330270
58Protein export_Homo sapiens_hsa030600.75978926
59Alcoholism_Homo sapiens_hsa050340.75834413
60Purine metabolism_Homo sapiens_hsa002300.73398833
61N-Glycan biosynthesis_Homo sapiens_hsa005100.70174997
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66893468
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66865105
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66796719
65Folate biosynthesis_Homo sapiens_hsa007900.65638897
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64960434
67* Gap junction_Homo sapiens_hsa045400.58489340
68Tight junction_Homo sapiens_hsa045300.57591148
69Bladder cancer_Homo sapiens_hsa052190.57418412
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57278277
71Chronic myeloid leukemia_Homo sapiens_hsa052200.56656178
72Viral carcinogenesis_Homo sapiens_hsa052030.53267769
73Sulfur relay system_Homo sapiens_hsa041220.53103977
74Fructose and mannose metabolism_Homo sapiens_hsa000510.53061618
75TGF-beta signaling pathway_Homo sapiens_hsa043500.52134311
76Vibrio cholerae infection_Homo sapiens_hsa051100.52117797
77Endometrial cancer_Homo sapiens_hsa052130.51757660
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51105162
79Huntingtons disease_Homo sapiens_hsa050160.47956364
80Fatty acid metabolism_Homo sapiens_hsa012120.46159955
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45379766
82Melanogenesis_Homo sapiens_hsa049160.43861506
83Prostate cancer_Homo sapiens_hsa052150.43177795
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40549405
85Small cell lung cancer_Homo sapiens_hsa052220.40267837
86Shigellosis_Homo sapiens_hsa051310.39970742
87Melanoma_Homo sapiens_hsa052180.39592622
88Propanoate metabolism_Homo sapiens_hsa006400.38557961
89Parkinsons disease_Homo sapiens_hsa050120.37515249
90AMPK signaling pathway_Homo sapiens_hsa041520.37043859
91Galactose metabolism_Homo sapiens_hsa000520.36044604
92Nicotine addiction_Homo sapiens_hsa050330.35650195
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.35221730
94Pathways in cancer_Homo sapiens_hsa052000.34144381
95Epstein-Barr virus infection_Homo sapiens_hsa051690.33918577
96Glioma_Homo sapiens_hsa052140.31148147
97Proteoglycans in cancer_Homo sapiens_hsa052050.30416867
98Notch signaling pathway_Homo sapiens_hsa043300.28591041
99ErbB signaling pathway_Homo sapiens_hsa040120.27230707
100HTLV-I infection_Homo sapiens_hsa051660.26992505

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