ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.17048436
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.83147404
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.78073337
4	ATP synthesis coupled proton transport (GO:0015986)	4.78073337
5	sequestering of actin monomers (GO:0042989)	4.76415691
6	protein complex biogenesis (GO:0070271)	4.48438125
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.47028624
8	behavioral response to nicotine (GO:0035095)	4.44914369
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.42402934
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.42402934
11	NADH dehydrogenase complex assembly (GO:0010257)	4.42402934
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.27727386
13	chaperone-mediated protein transport (GO:0072321)	4.27191928
14	nucleobase catabolic process (GO:0046113)	4.23282306
15	protein neddylation (GO:0045116)	4.19927168
16	mitochondrial respiratory chain complex assembly (GO:0033108)	4.05057525
17	protein-cofactor linkage (GO:0018065)	3.79548732
18	respiratory electron transport chain (GO:0022904)	3.76052153
19	electron transport chain (GO:0022900)	3.74472817
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.35133033
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.35133033
22	protein polyglutamylation (GO:0018095)	3.29529169
23	nonmotile primary cilium assembly (GO:0035058)	3.17148730
24	water-soluble vitamin biosynthetic process (GO:0042364)	3.16524480
25	cell proliferation in forebrain (GO:0021846)	3.15631836
26	retinal ganglion cell axon guidance (GO:0031290)	3.13335765
27	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.09862048
28	substrate-independent telencephalic tangential migration (GO:0021826)	3.09862048
29	negative regulation of telomere maintenance (GO:0032205)	3.05895477
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95579061
31	hydrogen ion transmembrane transport (GO:1902600)	2.92443992
32	establishment of mitochondrion localization (GO:0051654)	2.91692354
33	DNA deamination (GO:0045006)	2.90814317
34	cullin deneddylation (GO:0010388)	2.88023928
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.87450625
36	DNA damage response, detection of DNA damage (GO:0042769)	2.86158377
37	regulation of cilium movement (GO:0003352)	2.85461437
38	postsynaptic membrane organization (GO:0001941)	2.84885760
39	platelet dense granule organization (GO:0060155)	2.84756603
40	somite development (GO:0061053)	2.84140042
41	cornea development in camera-type eye (GO:0061303)	2.78200814
42	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.76469538
43	proton transport (GO:0015992)	2.74570624
44	protein deneddylation (GO:0000338)	2.72289491
45	neuron cell-cell adhesion (GO:0007158)	2.71757068
46	ATP biosynthetic process (GO:0006754)	2.70659499
47	respiratory chain complex IV assembly (GO:0008535)	2.70448049
48	transmission of nerve impulse (GO:0019226)	2.70348233
49	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.69736444
50	gamma-aminobutyric acid transport (GO:0015812)	2.69413482
51	hydrogen transport (GO:0006818)	2.68311604
52	mannosylation (GO:0097502)	2.67716658
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.66120877
54	protein localization to cilium (GO:0061512)	2.66051856
55	limb bud formation (GO:0060174)	2.65794051
56	termination of RNA polymerase III transcription (GO:0006386)	2.64084372
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.64084372
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.63805068
59	intracellular protein transmembrane import (GO:0044743)	2.59093970
60	neurofilament cytoskeleton organization (GO:0060052)	2.57133473
61	presynaptic membrane organization (GO:0097090)	2.56103525
62	positive regulation of mitochondrial fission (GO:0090141)	2.55921010
63	dendritic spine morphogenesis (GO:0060997)	2.55596753
64	epithelial cilium movement (GO:0003351)	2.55553160
65	proteasome assembly (GO:0043248)	2.52663025
66	cytochrome complex assembly (GO:0017004)	2.51986381
67	GTP biosynthetic process (GO:0006183)	2.51748572
68	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50959864
69	presynaptic membrane assembly (GO:0097105)	2.48853839
70	axonal fasciculation (GO:0007413)	2.48625047
71	regulation of development, heterochronic (GO:0040034)	2.48188728
72	DNA double-strand break processing (GO:0000729)	2.48122315
73	organelle disassembly (GO:1903008)	2.47480421
74	neuron fate determination (GO:0048664)	2.46126606
75	cilium morphogenesis (GO:0060271)	2.44538326
76	neural tube formation (GO:0001841)	2.44287200
77	regulation of timing of cell differentiation (GO:0048505)	2.42982286
78	fucose catabolic process (GO:0019317)	2.42365316
79	L-fucose metabolic process (GO:0042354)	2.42365316
80	L-fucose catabolic process (GO:0042355)	2.42365316
81	inner mitochondrial membrane organization (GO:0007007)	2.41849540
82	GPI anchor metabolic process (GO:0006505)	2.41569696
83	neuron recognition (GO:0008038)	2.41091861
84	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.40045664
85	regulation of action potential (GO:0098900)	2.39428975
86	regulation of microtubule-based movement (GO:0060632)	2.38762140
87	synaptic transmission, cholinergic (GO:0007271)	2.37656445
88	ubiquinone metabolic process (GO:0006743)	2.36980728
89	protein localization to mitochondrion (GO:0070585)	2.36033857
90	forebrain neuron differentiation (GO:0021879)	2.34958469
91	tRNA processing (GO:0008033)	2.33600825
92	synapse assembly (GO:0007416)	2.33120552
93	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.32654654
94	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.32616221
95	intraciliary transport (GO:0042073)	2.32161937
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.31776770
97	establishment of protein localization to mitochondrion (GO:0072655)	2.31763739
98	resolution of meiotic recombination intermediates (GO:0000712)	2.31590512
99	olfactory bulb development (GO:0021772)	2.31309890
100	hindbrain development (GO:0030902)	2.30853642

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.35850315
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.18198675
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.11727871
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.07444581
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06049651
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98244365
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.81886514
8	VDR_22108803_ChIP-Seq_LS180_Human	2.69830115
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.65836388
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39272018
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.35168793
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.27710250
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.25938040
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20224477
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.11538312
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95531819
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.95224486
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91348308
19	EWS_26573619_Chip-Seq_HEK293_Human	1.89799152
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89281195
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87896625
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83975380
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83788029
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81058551
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.78030424
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77904563
27	FUS_26573619_Chip-Seq_HEK293_Human	1.76387257
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.72308484
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.69826387
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66991138
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.65099750
32	P300_19829295_ChIP-Seq_ESCs_Human	1.63327532
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.62338429
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61755865
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.61701321
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60060195
37	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.55420188
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.53575360
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50860999
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47637045
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46011710
42	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45406149
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.42504217
44	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.40461560
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38434531
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.38073175
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.35605444
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.34323324
49	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.32363568
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32305194
51	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.30799530
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27545809
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26499603
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26155231
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.21825783
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20240615
57	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.18874787
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14945429
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14836737
60	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14065994
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13323091
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13323091
63	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.10490464
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09866172
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09691764
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.09604499
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09604499
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09585743
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.06356624
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04971729
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04857675
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04794347
73	AR_25329375_ChIP-Seq_VCAP_Human	1.04106071
74	NCOR_22424771_ChIP-Seq_293T_Human	1.02484558
75	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02280092
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01848815
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01616617
78	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01104429
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00646734
80	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00556786
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99953563
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99789810
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97139647
84	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.97134166
85	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.97081969
86	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97025213
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96570300
88	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96489214
89	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.95201545
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94837788
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92048848
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92048848
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.91851765
94	GABP_19822575_ChIP-Seq_HepG2_Human	0.91614020
95	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.91559008
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91371150
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91371150
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.90250092
99	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.86280984
100	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.85931054

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.17801446
2	MP0003880_abnormal_central_pattern	2.98980216
3	MP0003787_abnormal_imprinting	2.98079990
4	MP0003122_maternal_imprinting	2.67444296
5	MP0008877_abnormal_DNA_methylation	2.56090306
6	MP0002102_abnormal_ear_morphology	2.52349402
7	MP0001529_abnormal_vocalization	2.42806030
8	MP0006276_abnormal_autonomic_nervous	2.26070140
9	MP0003121_genomic_imprinting	2.24804756
10	MP0008789_abnormal_olfactory_epithelium	2.22075863
11	MP0002638_abnormal_pupillary_reflex	2.18911654
12	MP0000778_abnormal_nervous_system	2.09595752
13	MP0006072_abnormal_retinal_apoptosis	2.06304873
14	MP0002938_white_spotting	2.03137842
15	MP0005499_abnormal_olfactory_system	1.99658526
16	MP0005394_taste/olfaction_phenotype	1.99658526
17	MP0004142_abnormal_muscle_tone	1.98901760
18	MP0001968_abnormal_touch/_nociception	1.92789859
19	MP0002653_abnormal_ependyma_morphology	1.91431195
20	MP0001984_abnormal_olfaction	1.86211958
21	MP0003011_delayed_dark_adaptation	1.84656236
22	MP0002272_abnormal_nervous_system	1.81890510
23	MP0002736_abnormal_nociception_after	1.81308461
24	MP0005423_abnormal_somatic_nervous	1.81064158
25	MP0009745_abnormal_behavioral_response	1.79333063
26	MP0009046_muscle_twitch	1.75394958
27	MP0005645_abnormal_hypothalamus_physiol	1.69708662
28	MP0002837_dystrophic_cardiac_calcinosis	1.69463104
29	MP0005551_abnormal_eye_electrophysiolog	1.69412318
30	MP0005084_abnormal_gallbladder_morpholo	1.63605449
31	MP0004885_abnormal_endolymph	1.63569678
32	MP0002822_catalepsy	1.62203429
33	MP0000631_abnormal_neuroendocrine_gland	1.59804163
34	MP0001905_abnormal_dopamine_level	1.58127456
35	MP0002184_abnormal_innervation	1.57929640
36	MP0003635_abnormal_synaptic_transmissio	1.54901768
37	MP0002572_abnormal_emotion/affect_behav	1.54128805
38	MP0000049_abnormal_middle_ear	1.52153812
39	MP0004133_heterotaxia	1.49480984
40	MP0005253_abnormal_eye_physiology	1.48179065
41	MP0002557_abnormal_social/conspecific_i	1.45864678
42	MP0001986_abnormal_taste_sensitivity	1.44507804
43	MP0000569_abnormal_digit_pigmentation	1.43257981
44	MP0002063_abnormal_learning/memory/cond	1.39839877
45	MP0002735_abnormal_chemical_nociception	1.36367524
46	MP0001486_abnormal_startle_reflex	1.35356007
47	MP0002751_abnormal_autonomic_nervous	1.35110077
48	MP0000955_abnormal_spinal_cord	1.34832874
49	MP0004859_abnormal_synaptic_plasticity	1.33926886
50	MP0005646_abnormal_pituitary_gland	1.33346998
51	MP0002234_abnormal_pharynx_morphology	1.32769282
52	MP0002733_abnormal_thermal_nociception	1.32590054
53	MP0002064_seizures	1.31655639
54	MP0002734_abnormal_mechanical_nocicepti	1.31600915
55	MP0001970_abnormal_pain_threshold	1.31096360
56	MP0001485_abnormal_pinna_reflex	1.31055582
57	MP0002163_abnormal_gland_morphology	1.30710243
58	MP0008995_early_reproductive_senescence	1.26537176
59	MP0002752_abnormal_somatic_nervous	1.23343894
60	MP0004270_analgesia	1.22946984
61	MP0004742_abnormal_vestibular_system	1.20941534
62	MP0002067_abnormal_sensory_capabilities	1.20830292
63	MP0003136_yellow_coat_color	1.20325508
64	MP0001188_hyperpigmentation	1.17704032
65	MP0001293_anophthalmia	1.17161527
66	MP0004145_abnormal_muscle_electrophysio	1.17137789
67	MP0000372_irregular_coat_pigmentation	1.15868545
68	MP0000566_synostosis	1.14717106
69	MP0001440_abnormal_grooming_behavior	1.12851245
70	MP0003890_abnormal_embryonic-extraembry	1.12577815
71	MP0008872_abnormal_physiological_respon	1.12356246
72	MP0005195_abnormal_posterior_eye	1.09135576
73	MP0000026_abnormal_inner_ear	1.08262861
74	MP0002882_abnormal_neuron_morphology	1.07731453
75	MP0003938_abnormal_ear_development	0.99347644
76	MP0008058_abnormal_DNA_repair	0.99289899
77	MP0009379_abnormal_foot_pigmentation	0.98932388
78	MP0004924_abnormal_behavior	0.97972173
79	MP0005386_behavior/neurological_phenoty	0.97972173
80	MP0002160_abnormal_reproductive_system	0.95734730
81	MP0003718_maternal_effect	0.95335310
82	MP0005379_endocrine/exocrine_gland_phen	0.94775778
83	MP0004811_abnormal_neuron_physiology	0.94249461
84	MP0003937_abnormal_limbs/digits/tail_de	0.93172001
85	MP0003195_calcinosis	0.90426562
86	MP0001502_abnormal_circadian_rhythm	0.88351806
87	MP0002876_abnormal_thyroid_physiology	0.87855212
88	MP0002233_abnormal_nose_morphology	0.87705777
89	MP0005389_reproductive_system_phenotype	0.87347720
90	MP0002909_abnormal_adrenal_gland	0.86967198
91	MP0003283_abnormal_digestive_organ	0.86904243
92	MP0003119_abnormal_digestive_system	0.86375453
93	MP0004147_increased_porphyrin_level	0.85650065
94	MP0001286_abnormal_eye_development	0.84175772
95	MP0001963_abnormal_hearing_physiology	0.83440188
96	MP0002152_abnormal_brain_morphology	0.83036356
97	MP0008875_abnormal_xenobiotic_pharmacok	0.82905236
98	MP0000647_abnormal_sebaceous_gland	0.80391819
99	MP0002277_abnormal_respiratory_mucosa	0.80023221
100	MP0005391_vision/eye_phenotype	0.79789627

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.36893181
2	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87180017
3	Acute encephalopathy (HP:0006846)	3.70240016
4	Progressive macrocephaly (HP:0004481)	3.68490393
5	Mitochondrial inheritance (HP:0001427)	3.68207131
6	True hermaphroditism (HP:0010459)	3.52374299
7	Pancreatic cysts (HP:0001737)	3.51265866
8	Pancreatic fibrosis (HP:0100732)	3.48674089
9	Abnormality of the labia minora (HP:0012880)	3.36910172
10	Abnormality of midbrain morphology (HP:0002418)	3.34804109
11	Molar tooth sign on MRI (HP:0002419)	3.34804109
12	Increased CSF lactate (HP:0002490)	3.31708045
13	Hepatocellular necrosis (HP:0001404)	3.10317809
14	Nephronophthisis (HP:0000090)	3.03253673
15	Medial flaring of the eyebrow (HP:0010747)	3.00813841
16	Hepatic necrosis (HP:0002605)	2.99376725
17	Limb dystonia (HP:0002451)	2.86385043
18	Septo-optic dysplasia (HP:0100842)	2.85564017
19	Lissencephaly (HP:0001339)	2.85048729
20	Gait imbalance (HP:0002141)	2.82394251
21	Increased hepatocellular lipid droplets (HP:0006565)	2.80212414
22	Polyphagia (HP:0002591)	2.67974422
23	Lipid accumulation in hepatocytes (HP:0006561)	2.64587609
24	Cerebral edema (HP:0002181)	2.57535497
25	Type II lissencephaly (HP:0007260)	2.57364022
26	3-Methylglutaconic aciduria (HP:0003535)	2.56514829
27	Pendular nystagmus (HP:0012043)	2.54870592
28	Sclerocornea (HP:0000647)	2.51802665
29	Optic disc pallor (HP:0000543)	2.50578651
30	Optic nerve hypoplasia (HP:0000609)	2.50014967
31	Congenital primary aphakia (HP:0007707)	2.48860028
32	Pachygyria (HP:0001302)	2.48604357
33	Methylmalonic acidemia (HP:0002912)	2.44912108
34	Nephrogenic diabetes insipidus (HP:0009806)	2.44513370
35	Congenital stationary night blindness (HP:0007642)	2.44391136
36	Abnormality of the renal medulla (HP:0100957)	2.41088647
37	Myokymia (HP:0002411)	2.36753210
38	Renal Fanconi syndrome (HP:0001994)	2.34490134
39	Retinal dysplasia (HP:0007973)	2.32736568
40	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.29789951
41	Anencephaly (HP:0002323)	2.22136904
42	Poor suck (HP:0002033)	2.18631880
43	Hyperglycinemia (HP:0002154)	2.17711023
44	Abolished electroretinogram (ERG) (HP:0000550)	2.16218434
45	Genital tract atresia (HP:0001827)	2.13129157
46	Vaginal atresia (HP:0000148)	2.12470353
47	Abnormality of the renal cortex (HP:0011035)	2.12012594
48	Cystic liver disease (HP:0006706)	2.11763640
49	Increased serum lactate (HP:0002151)	2.11580132
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.11381943
51	Renal cortical cysts (HP:0000803)	2.09656774
52	Agitation (HP:0000713)	2.08753363
53	Colon cancer (HP:0003003)	2.05349363
54	Methylmalonic aciduria (HP:0012120)	2.03981564
55	Hypothermia (HP:0002045)	2.02325216
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01818104
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.01204009
58	Oligodactyly (hands) (HP:0001180)	2.00648103
59	Lactic acidosis (HP:0003128)	1.99424000
60	Leukodystrophy (HP:0002415)	1.98863460
61	Focal motor seizures (HP:0011153)	1.98422342
62	Absent septum pellucidum (HP:0001331)	1.97832466
63	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.96664517
64	Hypoplasia of the brainstem (HP:0002365)	1.96664517
65	Male pseudohermaphroditism (HP:0000037)	1.94458808
66	Chronic hepatic failure (HP:0100626)	1.90377010
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.90046805
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.90046805
69	Congenital, generalized hypertrichosis (HP:0004540)	1.89872386
70	Generalized aminoaciduria (HP:0002909)	1.88394606
71	Inability to walk (HP:0002540)	1.87865703
72	Respiratory failure (HP:0002878)	1.87119152
73	Hypoplastic pelvis (HP:0008839)	1.84098406
74	Postaxial hand polydactyly (HP:0001162)	1.83367883
75	Broad-based gait (HP:0002136)	1.81488231
76	Specific learning disability (HP:0001328)	1.80985563
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78944490
78	Short tibia (HP:0005736)	1.78731981
79	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78380293
80	Anophthalmia (HP:0000528)	1.77851525
81	Growth hormone deficiency (HP:0000824)	1.77208846
82	Postaxial foot polydactyly (HP:0001830)	1.77043319
83	Glycosuria (HP:0003076)	1.76823476
84	Abnormality of urine glucose concentration (HP:0011016)	1.76823476
85	Hyperventilation (HP:0002883)	1.76578625
86	Abnormal number of erythroid precursors (HP:0012131)	1.76104751
87	Narrow forehead (HP:0000341)	1.75947060
88	Occipital encephalocele (HP:0002085)	1.72429238
89	Abnormality of alanine metabolism (HP:0010916)	1.71821496
90	Hyperalaninemia (HP:0003348)	1.71821496
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71821496
92	Increased intramyocellular lipid droplets (HP:0012240)	1.71596003
93	Exertional dyspnea (HP:0002875)	1.71385406
94	Optic nerve coloboma (HP:0000588)	1.71131100
95	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.70418236
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69553142
97	Abnormality of renal resorption (HP:0011038)	1.69528799
98	Abnormality of cells of the erythroid lineage (HP:0012130)	1.69413630
99	Lethargy (HP:0001254)	1.68839964
100	Progressive cerebellar ataxia (HP:0002073)	1.68695111

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.32313014
2	MARK1	3.25774178
3	CASK	2.85873653
4	MAP4K2	2.80652530
5	DYRK2	2.72621967
6	MAPK13	2.41334637
7	MAP2K7	2.35620349
8	MAP3K4	2.26838001
9	ZAK	2.21735112
10	STK16	2.17868605
11	VRK2	2.14730960
12	ADRBK2	2.06108978
13	BCR	1.94385937
14	FRK	1.91800110
15	TRIM28	1.82101356
16	GRK1	1.74017443
17	TLK1	1.67103682
18	VRK1	1.65925954
19	CSNK1G2	1.64970943
20	WNK4	1.63923583
21	BMPR1B	1.62698273
22	PINK1	1.62570971
23	NUAK1	1.62262572
24	CSNK1G3	1.54156013
25	BUB1	1.48900615
26	MINK1	1.43143012
27	PAK3	1.35400743
28	CSNK1G1	1.32496524
29	SRPK1	1.32281407
30	PHKG1	1.30371672
31	PHKG2	1.30371672
32	BCKDK	1.25389721
33	EPHB2	1.25215902
34	PRKCG	1.23483920
35	NTRK2	1.23010373
36	CSNK1A1L	1.22290669
37	TSSK6	1.20587180
38	INSRR	1.17799308
39	ERBB3	1.08896600
40	TNIK	1.06504686
41	PNCK	1.05037337
42	LIMK1	1.02449508
43	DYRK3	1.02127869
44	NME1	1.02086408
45	PLK3	0.99297854
46	EPHA4	0.97637306
47	TIE1	0.97628594
48	UHMK1	0.93962303
49	SIK2	0.93647588
50	PLK2	0.93422880
51	OXSR1	0.87914196
52	PRKCE	0.85115941
53	CDK19	0.81740101
54	NEK1	0.81412025
55	TAOK3	0.79935314
56	MKNK2	0.73853781
57	PKN1	0.72943498
58	ADRBK1	0.72106623
59	STK39	0.69669968
60	NTRK3	0.69061964
61	MAP2K4	0.66746114
62	CAMK2A	0.64108570
63	TAF1	0.63872296
64	RPS6KA5	0.63037933
65	CDC7	0.62981007
66	WEE1	0.62903395
67	RPS6KA4	0.62109268
68	MKNK1	0.61752241
69	CCNB1	0.59697050
70	PLK1	0.58895076
71	DYRK1A	0.57784984
72	CSNK1A1	0.57648517
73	PRKACA	0.57418757
74	GRK7	0.52342768
75	PLK4	0.52095263
76	STK38L	0.51217319
77	AURKA	0.50900386
78	CAMKK2	0.49766059
79	CSNK1E	0.48514838
80	DAPK2	0.47168256
81	EIF2AK3	0.45711667
82	CDK14	0.44773290
83	TXK	0.43678420
84	CSNK2A1	0.42610579
85	PAK6	0.42196451
86	ATR	0.41578965
87	CDK5	0.41507949
88	MAPK15	0.40116427
89	MST4	0.39352675
90	CSNK2A2	0.39264247
91	PRKCZ	0.37870125
92	DYRK1B	0.36737524
93	MAP3K12	0.36147119
94	SGK494	0.35871082
95	SGK223	0.35871082
96	PRKG1	0.34464318
97	CDK18	0.33969162
98	PRKCI	0.33503540
99	AURKB	0.33432134
100	CHEK2	0.32665798

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.41249189
2	Parkinsons disease_Homo sapiens_hsa05012	3.72221205
3	Protein export_Homo sapiens_hsa03060	3.33246021
4	Proteasome_Homo sapiens_hsa03050	2.76573904
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.72385930
6	Huntingtons disease_Homo sapiens_hsa05016	2.50725127
7	Alzheimers disease_Homo sapiens_hsa05010	2.48922699
8	Ribosome_Homo sapiens_hsa03010	2.37842698
9	Nicotine addiction_Homo sapiens_hsa05033	2.36832686
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.34639738
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.28813506
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24179603
13	RNA polymerase_Homo sapiens_hsa03020	2.22767961
14	Phototransduction_Homo sapiens_hsa04744	2.08471680
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.02878568
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.02462831
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.89031989
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88626878
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.88130890
20	Butanoate metabolism_Homo sapiens_hsa00650	1.78594865
21	Basal transcription factors_Homo sapiens_hsa03022	1.62366721
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45559690
23	RNA degradation_Homo sapiens_hsa03018	1.38534784
24	GABAergic synapse_Homo sapiens_hsa04727	1.37385791
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28131944
26	Morphine addiction_Homo sapiens_hsa05032	1.26749478
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22245160
28	Propanoate metabolism_Homo sapiens_hsa00640	1.16809809
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11155385
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08008172
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07846213
32	Homologous recombination_Homo sapiens_hsa03440	1.06240163
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05163843
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03335204
35	One carbon pool by folate_Homo sapiens_hsa00670	1.01218406
36	Spliceosome_Homo sapiens_hsa03040	1.00862476
37	Mismatch repair_Homo sapiens_hsa03430	0.98261379
38	Taste transduction_Homo sapiens_hsa04742	0.96783132
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96689920
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96070361
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94660039
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.93057762
43	Peroxisome_Homo sapiens_hsa04146	0.91644336
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90877897
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86113565
46	Olfactory transduction_Homo sapiens_hsa04740	0.84246200
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.83839191
48	Circadian entrainment_Homo sapiens_hsa04713	0.83077373
49	RNA transport_Homo sapiens_hsa03013	0.81903918
50	Dopaminergic synapse_Homo sapiens_hsa04728	0.80614632
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.80167123
52	Fatty acid elongation_Homo sapiens_hsa00062	0.79243111
53	Insulin secretion_Homo sapiens_hsa04911	0.78761990
54	Purine metabolism_Homo sapiens_hsa00230	0.74653062
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.74468126
56	Metabolic pathways_Homo sapiens_hsa01100	0.74239071
57	Regulation of autophagy_Homo sapiens_hsa04140	0.74145310
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72799448
59	Folate biosynthesis_Homo sapiens_hsa00790	0.72428917
60	Serotonergic synapse_Homo sapiens_hsa04726	0.71923673
61	Cocaine addiction_Homo sapiens_hsa05030	0.68586110
62	Sulfur relay system_Homo sapiens_hsa04122	0.68327804
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67229919
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.65855812
65	Sulfur metabolism_Homo sapiens_hsa00920	0.64273496
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.62107501
67	Base excision repair_Homo sapiens_hsa03410	0.62020174
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61310124
69	Caffeine metabolism_Homo sapiens_hsa00232	0.58084413
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.57749211
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56517369
72	Alcoholism_Homo sapiens_hsa05034	0.55089147
73	Axon guidance_Homo sapiens_hsa04360	0.53365054
74	Retinol metabolism_Homo sapiens_hsa00830	0.53237696
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50576465
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49287786
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48567339
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.48340626
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48243415
80	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46853305
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45091248
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42534880
83	Amphetamine addiction_Homo sapiens_hsa05031	0.42350738
84	Oocyte meiosis_Homo sapiens_hsa04114	0.40888118
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40791990
86	DNA replication_Homo sapiens_hsa03030	0.40325448
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.40180047
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38936717
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.37714955
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35235036
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.34975926
92	Asthma_Homo sapiens_hsa05310	0.34357851
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.33020169
94	Glutathione metabolism_Homo sapiens_hsa00480	0.32834757
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32196754
96	Salivary secretion_Homo sapiens_hsa04970	0.31730688
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.31354945
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28689585
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28610533
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27934934

TUBAP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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