TUBA3FP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)8.43226618
2GDP-mannose metabolic process (GO:0019673)8.13500414
3mannose metabolic process (GO:0006013)8.08459185
4nucleoside transmembrane transport (GO:1901642)7.61347116
5nucleoside transport (GO:0015858)5.87575047
6response to pheromone (GO:0019236)5.17585092
7interferon-gamma production (GO:0032609)5.08098042
8behavioral response to nicotine (GO:0035095)5.03146324
9DNA deamination (GO:0045006)4.79199541
10reproduction (GO:0000003)4.40731180
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.34333582
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.20584602
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.20584602
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.19955055
15cofactor transport (GO:0051181)4.18667367
16peroxisome fission (GO:0016559)4.10900300
17short-chain fatty acid metabolic process (GO:0046459)4.10754586
18negative regulation of cAMP-mediated signaling (GO:0043951)3.77264082
19lateral ventricle development (GO:0021670)3.76328874
20response to misfolded protein (GO:0051788)3.73613011
21modified amino acid transport (GO:0072337)3.64258563
22water-soluble vitamin biosynthetic process (GO:0042364)3.54739571
23sulfur compound transport (GO:0072348)3.54234510
24pantothenate metabolic process (GO:0015939)3.49037775
25cellular response to estradiol stimulus (GO:0071392)3.45665850
26coenzyme A biosynthetic process (GO:0015937)3.45553723
27meiotic chromosome segregation (GO:0045132)3.43506357
28epithelial cilium movement (GO:0003351)3.41542437
29regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.38177521
30regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.38177521
31ATP synthesis coupled proton transport (GO:0015986)3.37351031
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37351031
33positive regulation of fatty acid transport (GO:2000193)3.36943371
34endoderm formation (GO:0001706)3.31096406
35positive regulation of icosanoid secretion (GO:0032305)3.29602453
36outer ear morphogenesis (GO:0042473)3.16444060
37regulation of neurotransmitter uptake (GO:0051580)3.14954963
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14911635
39histone H2A acetylation (GO:0043968)3.11896444
40protein polyglutamylation (GO:0018095)3.11783510
41piRNA metabolic process (GO:0034587)3.11562164
42nucleotide-sugar biosynthetic process (GO:0009226)3.07696126
43pyrimidine nucleobase catabolic process (GO:0006208)3.04879417
44cilium movement (GO:0003341)3.04482052
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01243021
46axoneme assembly (GO:0035082)3.01201447
47protein deneddylation (GO:0000338)3.00929731
48positive regulation of defense response to virus by host (GO:0002230)2.94327456
49indolalkylamine metabolic process (GO:0006586)2.92982802
50olfactory bulb development (GO:0021772)2.91313470
51axonemal dynein complex assembly (GO:0070286)2.89703333
52urinary tract smooth muscle contraction (GO:0014848)2.86335394
53transmission of nerve impulse (GO:0019226)2.86230576
54cellular biogenic amine catabolic process (GO:0042402)2.85914352
55amine catabolic process (GO:0009310)2.85914352
56regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.84689315
57carbohydrate derivative transport (GO:1901264)2.82503735
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78708131
59fucose catabolic process (GO:0019317)2.78390685
60L-fucose metabolic process (GO:0042354)2.78390685
61L-fucose catabolic process (GO:0042355)2.78390685
62protein localization to peroxisome (GO:0072662)2.75936614
63protein targeting to peroxisome (GO:0006625)2.75936614
64establishment of protein localization to peroxisome (GO:0072663)2.75936614
65spermatid development (GO:0007286)2.75762283
66homocysteine metabolic process (GO:0050667)2.74496940
67detection of light stimulus involved in visual perception (GO:0050908)2.73411461
68detection of light stimulus involved in sensory perception (GO:0050962)2.73411461
69otic vesicle formation (GO:0030916)2.71764061
70forebrain morphogenesis (GO:0048853)2.70874781
71cytidine deamination (GO:0009972)2.68255465
72cytidine metabolic process (GO:0046087)2.68255465
73cytidine catabolic process (GO:0006216)2.68255465
74serine family amino acid catabolic process (GO:0009071)2.66592021
75dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.66103096
76positive regulation of protein kinase C signaling (GO:0090037)2.65231841
77nucleobase catabolic process (GO:0046113)2.63353448
78cornea development in camera-type eye (GO:0061303)2.61081444
79cilium or flagellum-dependent cell motility (GO:0001539)2.60590988
80DNA methylation involved in gamete generation (GO:0043046)2.55540867
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53822182
82regulation of mitochondrial membrane potential (GO:0051881)2.52716350
83negative regulation of cell aging (GO:0090344)2.51517648
84positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.51111969
85nonmotile primary cilium assembly (GO:0035058)2.49305813
86regulation of cilium movement (GO:0003352)2.48602601
87positive regulation of organic acid transport (GO:0032892)2.48392616
88tryptophan catabolic process (GO:0006569)2.46496177
89indole-containing compound catabolic process (GO:0042436)2.46496177
90indolalkylamine catabolic process (GO:0046218)2.46496177
91reciprocal DNA recombination (GO:0035825)2.45896128
92reciprocal meiotic recombination (GO:0007131)2.45896128
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44235714
94negative regulation of execution phase of apoptosis (GO:1900118)2.39752075
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39363938
96cobalamin metabolic process (GO:0009235)2.38745652
97platelet dense granule organization (GO:0060155)2.37399298
98multicellular organism reproduction (GO:0032504)2.37333915
99synaptic transmission, cholinergic (GO:0007271)2.36031036
100coenzyme A metabolic process (GO:0015936)2.35255194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.16037967
2EZH2_22144423_ChIP-Seq_EOC_Human3.61230661
3ZNF274_21170338_ChIP-Seq_K562_Hela3.45672589
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24047899
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01629887
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96078549
7IGF1R_20145208_ChIP-Seq_DFB_Human2.85522044
8VDR_22108803_ChIP-Seq_LS180_Human2.79642717
9GBX2_23144817_ChIP-Seq_PC3_Human2.42879245
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39266171
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28539649
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08539773
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04687804
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99162067
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86719309
16FUS_26573619_Chip-Seq_HEK293_Human1.85024651
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84148954
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81345178
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78128171
20RNF2_27304074_Chip-Seq_NSC_Mouse1.65113038
21P300_19829295_ChIP-Seq_ESCs_Human1.64452258
22IRF1_19129219_ChIP-ChIP_H3396_Human1.63769750
23EWS_26573619_Chip-Seq_HEK293_Human1.62859574
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62463489
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61380226
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59646654
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.59280558
28TAF15_26573619_Chip-Seq_HEK293_Human1.57161810
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55970361
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50624291
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.47956757
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.46465469
33REST_21632747_ChIP-Seq_MESCs_Mouse1.46058722
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44897181
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44729288
36BCAT_22108803_ChIP-Seq_LS180_Human1.39303105
37TP53_22573176_ChIP-Seq_HFKS_Human1.38943443
38ER_23166858_ChIP-Seq_MCF-7_Human1.37137565
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36277814
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33664556
41NCOR_22424771_ChIP-Seq_293T_Human1.31137797
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30749080
43EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.27177716
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24250003
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24250003
46GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23989694
47PHF8_20622853_ChIP-Seq_HELA_Human1.23004472
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.22549371
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22539167
50ETV1_20927104_ChIP-Seq_GIST48_Human1.22129730
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21902004
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.20535337
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19757717
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.19757717
55AR_25329375_ChIP-Seq_VCAP_Human1.18621102
56RBPJ_21746931_ChIP-Seq_IB4_Human1.18022739
57NANOG_20526341_ChIP-Seq_ESCs_Human1.17344327
58SMAD4_21799915_ChIP-Seq_A2780_Human1.16413322
59MYC_19829295_ChIP-Seq_ESCs_Human1.16178193
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16089681
61CBP_20019798_ChIP-Seq_JUKART_Human1.16089681
62PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15656710
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15224461
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14149698
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.14078788
66MYC_18940864_ChIP-ChIP_HL60_Human1.13526151
67STAT3_23295773_ChIP-Seq_U87_Human1.13000901
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12080470
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.11892255
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10754710
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10668657
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10627838
73NFYB_21822215_ChIP-Seq_K562_Human1.10465953
74TCF4_22108803_ChIP-Seq_LS180_Human1.09725070
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.09707635
76NFYA_21822215_ChIP-Seq_K562_Human1.08208504
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.08156416
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.07651267
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07647037
80TBL1_22424771_ChIP-Seq_293T_Human1.07211601
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.07160544
82NANOG_19829295_ChIP-Seq_ESCs_Human1.06377093
83SOX2_19829295_ChIP-Seq_ESCs_Human1.06377093
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05858576
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05852124
86CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05206875
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.04926153
88TCF4_23295773_ChIP-Seq_U87_Human1.03690410
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03227078
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.02876847
91FOXH1_21741376_ChIP-Seq_ESCs_Human1.01102230
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00720463
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00351234
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00100684
95HNFA_21074721_ChIP-Seq_CACO-2_Human0.99617217
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98937732
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98862123
98AR_21572438_ChIP-Seq_LNCaP_Human0.98397076
99ETS1_20019798_ChIP-Seq_JURKAT_Human0.97402695
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97395143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.33728377
2MP0006072_abnormal_retinal_apoptosis3.51670517
3MP0004043_abnormal_pH_regulation2.95835180
4MP0003646_muscle_fatigue2.65259600
5MP0002102_abnormal_ear_morphology2.51961786
6MP0001529_abnormal_vocalization2.29448467
7MP0006292_abnormal_olfactory_placode2.26747574
8MP0003880_abnormal_central_pattern2.20946899
9MP0005551_abnormal_eye_electrophysiolog2.13685845
10MP0004133_heterotaxia2.13196489
11MP0005253_abnormal_eye_physiology2.11544217
12MP0008877_abnormal_DNA_methylation2.04350596
13MP0001968_abnormal_touch/_nociception1.93545332
14MP0002837_dystrophic_cardiac_calcinosis1.81155560
15MP0006276_abnormal_autonomic_nervous1.78273919
16MP0000372_irregular_coat_pigmentation1.77213104
17MP0004270_analgesia1.69392115
18MP0000778_abnormal_nervous_system1.64199067
19MP0001986_abnormal_taste_sensitivity1.63936423
20MP0002160_abnormal_reproductive_system1.63908780
21MP0009745_abnormal_behavioral_response1.61620941
22MP0002736_abnormal_nociception_after1.58600596
23MP0005174_abnormal_tail_pigmentation1.47289536
24MP0002234_abnormal_pharynx_morphology1.46315627
25MP0004885_abnormal_endolymph1.43460059
26MP0005646_abnormal_pituitary_gland1.43138516
27MP0002272_abnormal_nervous_system1.43107165
28MP0002938_white_spotting1.40768002
29MP0003011_delayed_dark_adaptation1.40420089
30MP0004142_abnormal_muscle_tone1.39951442
31MP0009046_muscle_twitch1.38997801
32MP0003890_abnormal_embryonic-extraembry1.38934841
33MP0003195_calcinosis1.38359576
34MP0008872_abnormal_physiological_respon1.37707371
35MP0005423_abnormal_somatic_nervous1.37166258
36MP0002572_abnormal_emotion/affect_behav1.36763658
37MP0008789_abnormal_olfactory_epithelium1.36635632
38MP0003787_abnormal_imprinting1.34939733
39MP0002822_catalepsy1.33525256
40MP0005645_abnormal_hypothalamus_physiol1.32935241
41MP0002163_abnormal_gland_morphology1.31315910
42MP0001485_abnormal_pinna_reflex1.30624412
43MP0005084_abnormal_gallbladder_morpholo1.30105455
44MP0005389_reproductive_system_phenotype1.29430211
45MP0003136_yellow_coat_color1.27924752
46MP0001501_abnormal_sleep_pattern1.27892120
47MP0003878_abnormal_ear_physiology1.27129086
48MP0005377_hearing/vestibular/ear_phenot1.27129086
49MP0002557_abnormal_social/conspecific_i1.26756431
50MP0001727_abnormal_embryo_implantation1.25616430
51MP0001905_abnormal_dopamine_level1.24088139
52MP0005083_abnormal_biliary_tract1.23430892
53MP0002734_abnormal_mechanical_nocicepti1.21577086
54MP0005195_abnormal_posterior_eye1.21125001
55MP0002653_abnormal_ependyma_morphology1.20533953
56MP0002876_abnormal_thyroid_physiology1.20475055
57MP0000631_abnormal_neuroendocrine_gland1.19425784
58MP0008875_abnormal_xenobiotic_pharmacok1.18983454
59MP0004147_increased_porphyrin_level1.18576031
60MP0005386_behavior/neurological_phenoty1.13285791
61MP0004924_abnormal_behavior1.13285791
62MP0005410_abnormal_fertilization1.12957197
63MP0002063_abnormal_learning/memory/cond1.11912452
64MP0002733_abnormal_thermal_nociception1.11386201
65MP0002752_abnormal_somatic_nervous1.10011994
66MP0005394_taste/olfaction_phenotype1.08226142
67MP0005499_abnormal_olfactory_system1.08226142
68MP0001970_abnormal_pain_threshold1.08119005
69MP0001486_abnormal_startle_reflex1.05748547
70MP0003635_abnormal_synaptic_transmissio1.05471515
71MP0002210_abnormal_sex_determination1.04770553
72MP0004145_abnormal_muscle_electrophysio1.04112152
73MP0008995_early_reproductive_senescence1.02974718
74MP0002064_seizures1.01652464
75MP0003698_abnormal_male_reproductive1.00787999
76MP0002735_abnormal_chemical_nociception1.00534315
77MP0002184_abnormal_innervation0.99819919
78MP0005671_abnormal_response_to0.96271496
79MP0005379_endocrine/exocrine_gland_phen0.94225899
80MP0000049_abnormal_middle_ear0.93670174
81MP0010386_abnormal_urinary_bladder0.92142420
82MP0002751_abnormal_autonomic_nervous0.91975974
83MP0001984_abnormal_olfaction0.90969431
84MP0001929_abnormal_gametogenesis0.90551188
85MP0001502_abnormal_circadian_rhythm0.90047005
86MP0003122_maternal_imprinting0.89492515
87MP0000955_abnormal_spinal_cord0.89334538
88MP0001188_hyperpigmentation0.88459150
89MP0004742_abnormal_vestibular_system0.86772584
90MP0000427_abnormal_hair_cycle0.86495096
91MP0002067_abnormal_sensory_capabilities0.84786638
92MP0000653_abnormal_sex_gland0.83843240
93MP0005391_vision/eye_phenotype0.83125850
94MP0002095_abnormal_skin_pigmentation0.83025417
95MP0005220_abnormal_exocrine_pancreas0.82916894
96MP0002882_abnormal_neuron_morphology0.81407199
97MP0000026_abnormal_inner_ear0.80395319
98MP0005085_abnormal_gallbladder_physiolo0.78233794
99MP0001145_abnormal_male_reproductive0.77853996
100MP0003137_abnormal_impulse_conducting0.77596755

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)5.69227114
2Hypobetalipoproteinemia (HP:0003563)4.53760806
3Methylmalonic acidemia (HP:0002912)4.13361233
4Akinesia (HP:0002304)4.10174620
5Hyperglycinemia (HP:0002154)4.06746064
6Dyskinesia (HP:0100660)3.99507353
7Congenital stationary night blindness (HP:0007642)3.70083538
8Acanthocytosis (HP:0001927)3.60691203
9Neurodegeneration (HP:0002180)3.56683151
10Tubulointerstitial nephritis (HP:0001970)3.45634631
11Pancreatic cysts (HP:0001737)3.41864518
12Methylmalonic aciduria (HP:0012120)3.41779386
13Molar tooth sign on MRI (HP:0002419)3.41604277
14Abnormality of midbrain morphology (HP:0002418)3.41604277
15Pancreatic fibrosis (HP:0100732)3.27782017
16Abnormality of the phalanges of the 2nd finger (HP:0009541)3.22306870
17True hermaphroditism (HP:0010459)3.20172356
18Hypoplasia of the pons (HP:0012110)3.06332448
19Decreased muscle mass (HP:0003199)3.05128297
20Patent foramen ovale (HP:0001655)2.98789371
21Agitation (HP:0000713)2.97005317
22Amblyopia (HP:0000646)2.92597795
23Nephronophthisis (HP:0000090)2.91643184
24Delayed CNS myelination (HP:0002188)2.84734554
25Abnormality of the pons (HP:0007361)2.83591473
26Type II lissencephaly (HP:0007260)2.78800633
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.65046943
28Abolished electroretinogram (ERG) (HP:0000550)2.62978541
29Abnormality of vitamin B metabolism (HP:0004340)2.62114434
30Diminished movement (HP:0002374)2.54846810
31Abnormality of the vitamin B12 metabolism (HP:0004341)2.53694189
32Medial flaring of the eyebrow (HP:0010747)2.53041469
33Ketoacidosis (HP:0001993)2.51487382
34Abnormality of alanine metabolism (HP:0010916)2.44542581
35Hyperalaninemia (HP:0003348)2.44542581
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44542581
37Abnormality of the renal medulla (HP:0100957)2.40738611
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40536381
39Brushfield spots (HP:0001088)2.38663203
40Abnormal rod and cone electroretinograms (HP:0008323)2.35885962
41Congenital sensorineural hearing impairment (HP:0008527)2.35331716
42Clumsiness (HP:0002312)2.34854250
43Abnormality of the renal cortex (HP:0011035)2.32081765
44Abnormality of glycine metabolism (HP:0010895)2.26515424
45Abnormality of serine family amino acid metabolism (HP:0010894)2.26515424
46Abnormal respiratory motile cilium physiology (HP:0012261)2.24632516
47Increased CSF lactate (HP:0002490)2.21323738
48Abnormal respiratory epithelium morphology (HP:0012253)2.20879331
49Abnormal respiratory motile cilium morphology (HP:0005938)2.20879331
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19639939
51Cerebellar dysplasia (HP:0007033)2.16770280
52Microretrognathia (HP:0000308)2.16394477
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16092508
54Chronic hepatic failure (HP:0100626)2.15776895
55Attenuation of retinal blood vessels (HP:0007843)2.15647325
56Abnormal ciliary motility (HP:0012262)2.14889711
57Gait imbalance (HP:0002141)2.10144924
58Absent/shortened dynein arms (HP:0200106)2.10034470
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.10034470
60Tubular atrophy (HP:0000092)2.08795216
61Morphological abnormality of the pyramidal tract (HP:0002062)2.05868364
62Mitochondrial inheritance (HP:0001427)2.04952074
63Tubulointerstitial abnormality (HP:0001969)2.04915027
64Ketosis (HP:0001946)2.04773147
65Abnormality of serum amino acid levels (HP:0003112)2.03800241
66Broad distal phalanx of finger (HP:0009836)2.03565907
67Congenital primary aphakia (HP:0007707)2.03491799
68Dysphonia (HP:0001618)2.02994543
69Pendular nystagmus (HP:0012043)2.02592177
70Restlessness (HP:0000711)2.02273403
71Polydipsia (HP:0001959)2.01755161
72Abnormal drinking behavior (HP:0030082)2.01755161
73Retinitis pigmentosa (HP:0000510)1.99047930
74Cystic liver disease (HP:0006706)1.98426201
75Craniofacial dystonia (HP:0012179)1.98364328
76Focal dystonia (HP:0004373)1.97850862
77Rhinitis (HP:0012384)1.97689852
78Buphthalmos (HP:0000557)1.95603959
79Hepatocellular necrosis (HP:0001404)1.93672021
80CNS demyelination (HP:0007305)1.93598772
81Sclerocornea (HP:0000647)1.93507589
82Hepatic necrosis (HP:0002605)1.93181958
83Retinal dysplasia (HP:0007973)1.90078520
84Nephrogenic diabetes insipidus (HP:0009806)1.86758286
85Hemiplegia (HP:0002301)1.86039747
86Increased hepatocellular lipid droplets (HP:0006565)1.84842070
87Congenital glaucoma (HP:0001087)1.83130874
88Lipid accumulation in hepatocytes (HP:0006561)1.82312508
89Decreased central vision (HP:0007663)1.82300809
90Bony spicule pigmentary retinopathy (HP:0007737)1.81446947
91Long nose (HP:0003189)1.81410221
92Anencephaly (HP:0002323)1.81174363
93Hypothermia (HP:0002045)1.78873980
94Male pseudohermaphroditism (HP:0000037)1.78586086
95Hyperventilation (HP:0002883)1.75871435
96Occipital encephalocele (HP:0002085)1.75210992
97Hypolipoproteinemia (HP:0010981)1.74438603
98Abnormality of vitamin metabolism (HP:0100508)1.73900225
99Decreased circulating renin level (HP:0003351)1.73540362
100Poor suck (HP:0002033)1.72841760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.51125361
2MAP4K22.62080280
3ADRBK22.60997069
4WNK32.60554183
5PDK22.59071192
6GRK12.53651379
7PINK12.44000987
8ERN12.35268190
9WNK42.23068558
10NUAK12.05332663
11ZAK2.04795766
12INSRR2.01198279
13MAP2K61.96893769
14BMPR1B1.91688835
15MUSK1.82391728
16MAPK131.72723460
17NEK21.70264178
18OXSR11.68144718
19MAP3K41.64303320
20MARK11.56412239
21TRIM281.54733167
22TXK1.52926933
23CASK1.45168630
24TLK11.44123071
25CCNB11.39611593
26BCR1.34961364
27BCKDK1.30522343
28PKN11.19720892
29STK391.18784975
30TAOK31.17135019
31DYRK21.16480320
32MAP2K71.11884102
33STK381.11523761
34EPHA41.09129526
35PLK21.05242080
36CSNK1G30.98374089
37ADRBK10.97879561
38NTRK30.95459152
39CSNK1G20.94385527
40MAPK150.94060257
41TNIK0.93745292
42PRKCG0.92739778
43PRKCE0.92088620
44PHKG20.91205788
45PHKG10.91205788
46ACVR1B0.90322311
47AKT20.89329841
48PAK30.85390499
49TESK20.84757231
50CSNK1G10.82989955
51TGFBR10.80913444
52PRKD20.80200568
53OBSCN0.79448591
54NTRK20.78240889
55FGFR20.76711693
56MARK30.76073811
57TIE10.75601871
58VRK10.74813227
59MINK10.72652657
60PLK40.71686251
61CSNK1A1L0.71256600
62CAMKK20.70962762
63CAMK2A0.70232871
64PRKCQ0.66952752
65LCK0.64928036
66MKNK20.63208157
67MAP2K40.61475984
68GRK50.59492233
69VRK20.59190588
70PRKACA0.58717100
71DAPK20.58371990
72ERBB30.57794525
73DYRK1A0.57131412
74STK160.56734818
75PRKCA0.55541307
76SIK20.54439077
77PRKCZ0.54336044
78CDK190.54151576
79PRKCH0.53604543
80TNK20.53107624
81PTK2B0.52041589
82STK30.51731765
83SGK20.50420456
84SGK4940.48609537
85SGK2230.48609537
86PIK3CG0.48300207
87PLK30.46996744
88PASK0.46838474
89SYK0.45810987
90CSNK1A10.45232437
91GRK70.43987119
92LIMK10.40363630
93ATR0.40092523
94CAMK10.39976032
95RPS6KA50.39933258
96CSNK2A10.39775254
97PIM10.36296900
98PRKCI0.34882559
99DYRK30.34755297
100CAMK2D0.34471285

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.78644364
2Linoleic acid metabolism_Homo sapiens_hsa005912.74998379
3Phototransduction_Homo sapiens_hsa047442.73232265
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.67092995
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56602946
6Selenocompound metabolism_Homo sapiens_hsa004502.45209020
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37318544
8Oxidative phosphorylation_Homo sapiens_hsa001902.35581096
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08419282
10Regulation of autophagy_Homo sapiens_hsa041402.06942317
11Parkinsons disease_Homo sapiens_hsa050122.05666121
12RNA degradation_Homo sapiens_hsa030181.99710461
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.86981788
14Butanoate metabolism_Homo sapiens_hsa006501.85392147
15Propanoate metabolism_Homo sapiens_hsa006401.83562114
16Nicotine addiction_Homo sapiens_hsa050331.82703990
17Ether lipid metabolism_Homo sapiens_hsa005651.74448038
18Nitrogen metabolism_Homo sapiens_hsa009101.71163178
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69116544
20Ribosome_Homo sapiens_hsa030101.68319650
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65717183
22Caffeine metabolism_Homo sapiens_hsa002321.55621919
23Olfactory transduction_Homo sapiens_hsa047401.55220210
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51774401
25Fructose and mannose metabolism_Homo sapiens_hsa000511.49811291
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47758680
27Peroxisome_Homo sapiens_hsa041461.39212393
28Tryptophan metabolism_Homo sapiens_hsa003801.37833031
29Cardiac muscle contraction_Homo sapiens_hsa042601.36250710
30Fanconi anemia pathway_Homo sapiens_hsa034601.31569605
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29695049
32Alzheimers disease_Homo sapiens_hsa050101.28478570
33RNA polymerase_Homo sapiens_hsa030201.27578675
34Huntingtons disease_Homo sapiens_hsa050161.26546642
35Taste transduction_Homo sapiens_hsa047421.22399024
36Arachidonic acid metabolism_Homo sapiens_hsa005901.22260858
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21605609
38GABAergic synapse_Homo sapiens_hsa047271.20717305
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17421617
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16465678
41Basal transcription factors_Homo sapiens_hsa030221.14579144
42Morphine addiction_Homo sapiens_hsa050321.13363218
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12421459
44Protein export_Homo sapiens_hsa030601.09285154
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07277955
46Steroid biosynthesis_Homo sapiens_hsa001001.05823305
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05192874
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.03637563
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99741786
50Insulin secretion_Homo sapiens_hsa049110.98106715
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97012652
52Homologous recombination_Homo sapiens_hsa034400.94664634
53Chemical carcinogenesis_Homo sapiens_hsa052040.93603037
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90714717
55Retinol metabolism_Homo sapiens_hsa008300.87954372
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.87769272
57Type I diabetes mellitus_Homo sapiens_hsa049400.83730870
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83620498
59Glutamatergic synapse_Homo sapiens_hsa047240.81969712
60Circadian entrainment_Homo sapiens_hsa047130.81961104
61Fat digestion and absorption_Homo sapiens_hsa049750.81306234
62Proteasome_Homo sapiens_hsa030500.79939596
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78574805
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77313266
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73426536
66Metabolic pathways_Homo sapiens_hsa011000.73341690
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71045458
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.69260741
69Purine metabolism_Homo sapiens_hsa002300.67830115
70Serotonergic synapse_Homo sapiens_hsa047260.66982004
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65710660
72Asthma_Homo sapiens_hsa053100.64553958
73Autoimmune thyroid disease_Homo sapiens_hsa053200.63555033
74Allograft rejection_Homo sapiens_hsa053300.62635271
75Ovarian steroidogenesis_Homo sapiens_hsa049130.61640761
76Collecting duct acid secretion_Homo sapiens_hsa049660.59900695
77Hedgehog signaling pathway_Homo sapiens_hsa043400.59860990
78One carbon pool by folate_Homo sapiens_hsa006700.58768264
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57606913
80Salivary secretion_Homo sapiens_hsa049700.56337039
81Dopaminergic synapse_Homo sapiens_hsa047280.55977953
82Cocaine addiction_Homo sapiens_hsa050300.54040978
83Graft-versus-host disease_Homo sapiens_hsa053320.53628304
84Calcium signaling pathway_Homo sapiens_hsa040200.52676271
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52554625
86ABC transporters_Homo sapiens_hsa020100.49271594
87beta-Alanine metabolism_Homo sapiens_hsa004100.44203571
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41705305
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40320213
90Amphetamine addiction_Homo sapiens_hsa050310.38098564
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35880836
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.35472072
93Synaptic vesicle cycle_Homo sapiens_hsa047210.34889495
94Glutathione metabolism_Homo sapiens_hsa004800.33010118
95Sulfur relay system_Homo sapiens_hsa041220.32951978
96Pyrimidine metabolism_Homo sapiens_hsa002400.32853480
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31202546
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.31141760
99Primary immunodeficiency_Homo sapiens_hsa053400.29167074
100Axon guidance_Homo sapiens_hsa043600.28635484

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