TTPAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)8.30897163
2negative regulation of glycogen biosynthetic process (GO:0045719)8.24288284
3UDP-N-acetylglucosamine metabolic process (GO:0006047)7.14201747
4negative regulation of glycogen metabolic process (GO:0070874)6.49798870
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.09617497
6phosphorelay signal transduction system (GO:0000160)5.92979561
7membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.89620266
8positive regulation of cardiac muscle cell differentiation (GO:2000727)5.74919403
9somite development (GO:0061053)5.49425841
10gamma-aminobutyric acid transport (GO:0015812)5.43153810
11positive regulation of gamma-delta T cell activation (GO:0046645)5.38935844
12regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)5.29032470
13chaperone-mediated protein complex assembly (GO:0051131)5.27062596
14membrane repolarization during action potential (GO:0086011)5.22048834
15B cell receptor signaling pathway (GO:0050853)5.09074770
16kidney morphogenesis (GO:0060993)5.00289588
17ovulation cycle (GO:0042698)4.98328403
18regulation of non-canonical Wnt signaling pathway (GO:2000050)4.88460390
19regulation of glomerulus development (GO:0090192)4.83498330
20lung secretory cell differentiation (GO:0061140)4.82120929
21lateral sprouting from an epithelium (GO:0060601)4.59928281
22antigen processing and presentation of endogenous antigen (GO:0019883)4.58291642
23regulation of B cell receptor signaling pathway (GO:0050855)4.56694250
24positive regulation of glomerulus development (GO:0090193)4.46347533
25head development (GO:0060322)4.45098883
26cell proliferation in forebrain (GO:0021846)4.37931035
27regulation of phospholipase A2 activity (GO:0032429)4.37033333
28regulation of gamma-delta T cell differentiation (GO:0045586)4.34234471
29negative regulation of cell killing (GO:0031342)4.32600705
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32600705
31negative regulation of fatty acid transport (GO:2000192)4.32069559
32response to pheromone (GO:0019236)4.27055666
33positive regulation of synapse maturation (GO:0090129)4.21470405
34negative regulation of cardiac muscle tissue growth (GO:0055022)4.19649174
35negative regulation of heart growth (GO:0061117)4.19649174
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13663216
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.13663216
38lung morphogenesis (GO:0060425)4.07356086
39smooth muscle tissue development (GO:0048745)4.00119808
40behavioral response to nicotine (GO:0035095)3.99569531
41spinal cord development (GO:0021510)3.97150647
42regulation of gamma-delta T cell activation (GO:0046643)3.94823551
43replicative senescence (GO:0090399)3.86568780
44negative regulation of cardiac muscle tissue development (GO:0055026)3.85018557
45locomotory exploration behavior (GO:0035641)3.80050653
46cellular anion homeostasis (GO:0030002)3.77909234
47positive thymic T cell selection (GO:0045059)3.76722410
48negative regulation of astrocyte differentiation (GO:0048712)3.74161965
49segment specification (GO:0007379)3.73143830
50response to interleukin-15 (GO:0070672)3.73138201
51endoderm formation (GO:0001706)3.72844382
52cellular response to ATP (GO:0071318)3.70406827
53water-soluble vitamin biosynthetic process (GO:0042364)3.70142486
54positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.69635114
55serotonin metabolic process (GO:0042428)3.69331131
56regulation of synaptic vesicle exocytosis (GO:2000300)3.68648052
57neuron remodeling (GO:0016322)3.68543693
58negative thymic T cell selection (GO:0045060)3.66849283
59estrogen metabolic process (GO:0008210)3.65971240
60positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.65610468
61axon ensheathment in central nervous system (GO:0032291)3.63216585
62central nervous system myelination (GO:0022010)3.63216585
63regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.61154111
64negative T cell selection (GO:0043383)3.59404753
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58714849
66sulfation (GO:0051923)3.55292019
67regulation of synapse maturation (GO:0090128)3.55238120
68positive regulation of icosanoid secretion (GO:0032305)3.54877964
69synaptic vesicle maturation (GO:0016188)3.54382744
70membrane repolarization (GO:0086009)3.53489895
71regulation of ARF protein signal transduction (GO:0032012)3.53242497
72cellular potassium ion homeostasis (GO:0030007)3.53185329
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.52402792
74positive T cell selection (GO:0043368)3.47984943
75positive regulation of fatty acid transport (GO:2000193)3.47317944
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.45950411
77primary amino compound metabolic process (GO:1901160)3.43119979
78regulation of mesoderm development (GO:2000380)3.39867440
79magnesium ion transport (GO:0015693)3.39663346
80regulation of cardiac muscle cell differentiation (GO:2000725)3.37323164
81negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.36714577
82negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.36675089
83protein polyglutamylation (GO:0018095)3.36323181
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.35623823
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35317177
86glucosamine-containing compound metabolic process (GO:1901071)3.34072340
87cellular response to interleukin-15 (GO:0071350)3.32947716
88T cell selection (GO:0045058)3.32864865
89positive regulation of mesonephros development (GO:0061213)3.29652119
90thymic T cell selection (GO:0045061)3.29581880
91regulation of receptor binding (GO:1900120)3.28688735
92regulation of mesonephros development (GO:0061217)3.28586117
93cellular response to interferon-beta (GO:0035458)3.28246707
94regulation of B cell differentiation (GO:0045577)3.26308251
95positive regulation of Rap GTPase activity (GO:0032854)3.25310301
96DNA deamination (GO:0045006)3.24888359
97positive regulation of B cell differentiation (GO:0045579)3.24027285
98regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21807446
99negative regulation of hormone biosynthetic process (GO:0032353)3.20871111
100synaptic vesicle exocytosis (GO:0016079)3.19831408
101nucleotide-sugar biosynthetic process (GO:0009226)3.19572239
102regulation of cardiac muscle cell proliferation (GO:0060043)3.18302242
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18300599
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18300599
105neuronal action potential propagation (GO:0019227)3.17712978
106regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17064773
107appendage development (GO:0048736)3.16486610
108limb development (GO:0060173)3.16486610
109purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.16368924
1103-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.16368924
111retinal ganglion cell axon guidance (GO:0031290)3.15970525
112transmission of nerve impulse (GO:0019226)3.13498653
113regulation of membrane repolarization (GO:0060306)3.08142224
114negative regulation of protein tyrosine kinase activity (GO:0061099)3.08125347
115negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.05875668
116antigen receptor-mediated signaling pathway (GO:0050851)3.05831987
117regulation of Rap GTPase activity (GO:0032317)3.04954823
118regulation of DNA endoreduplication (GO:0032875)3.04101258
119interferon-gamma secretion (GO:0072643)3.03518949
120negative regulation of Rho protein signal transduction (GO:0035024)3.01896583
121cellular response to zinc ion (GO:0071294)3.01197542
122positive regulation of triglyceride biosynthetic process (GO:0010867)2.99904839
123regulation of synaptic vesicle transport (GO:1902803)2.98042415
124glutamate secretion (GO:0014047)2.96992345
125pituitary gland development (GO:0021983)2.96137382
126somatic diversification of immunoglobulins (GO:0016445)2.95843248
127positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95717141
128germinal center formation (GO:0002467)2.90228848
129G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89938529
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.89770443
131lens fiber cell differentiation (GO:0070306)2.88703447
132B cell proliferation (GO:0042100)2.88246613
133regulation of potassium ion transmembrane transport (GO:1901379)2.87638522
134mature B cell differentiation (GO:0002335)2.87006512
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.84158688
136cell differentiation in hindbrain (GO:0021533)2.83028420
137regulation of heart rate by cardiac conduction (GO:0086091)2.82362417
138T cell costimulation (GO:0031295)2.81576425
139negative regulation of organelle assembly (GO:1902116)2.80761262
140glutamine metabolic process (GO:0006541)2.80666776
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80609325
142multicellular organismal signaling (GO:0035637)2.80586072
143regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80037178
144exploration behavior (GO:0035640)2.79553575
145clathrin coat assembly (GO:0048268)2.78713894
146lymphocyte costimulation (GO:0031294)2.75945553
147mast cell degranulation (GO:0043303)2.75799243
148mast cell activation involved in immune response (GO:0002279)2.75799243
149serine transport (GO:0032329)2.73372297
150regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67455474
151regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66959442
152regulation of T cell tolerance induction (GO:0002664)2.63981354
153regulation of glutamate receptor signaling pathway (GO:1900449)2.63784593
154lymphocyte homeostasis (GO:0002260)2.63124165
155positive regulation of histone deacetylation (GO:0031065)2.60769011
156immune response-activating cell surface receptor signaling pathway (GO:0002429)2.60650005
157positive regulation of muscle hypertrophy (GO:0014742)2.59803050
158positive regulation of cardiac muscle hypertrophy (GO:0010613)2.59803050
159B cell homeostasis (GO:0001782)2.59362709
160nerve growth factor signaling pathway (GO:0038180)2.58346863
161regulation of B cell proliferation (GO:0030888)2.53983090
162regulation of interferon-beta biosynthetic process (GO:0045357)2.51892971
163regulation of synapse structural plasticity (GO:0051823)2.50871776
164regulation of regulatory T cell differentiation (GO:0045589)2.49649212
165T cell homeostasis (GO:0043029)2.48909529
166sodium ion export (GO:0071436)2.48085306
167mast cell activation (GO:0045576)2.47411140
168negative regulation of T cell receptor signaling pathway (GO:0050860)2.44990377
169T cell receptor signaling pathway (GO:0050852)2.44974734
170L-serine transport (GO:0015825)2.43272021
171positive regulation of macrophage differentiation (GO:0045651)2.42721645
172vocalization behavior (GO:0071625)2.42301523
173negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.40691854
174leukocyte aggregation (GO:0070486)2.40632880
175activation of protein kinase A activity (GO:0034199)2.40129505
176regulation of ARF GTPase activity (GO:0032312)2.39524787
177macrophage activation involved in immune response (GO:0002281)2.39489330
178activation of JUN kinase activity (GO:0007257)2.35994307
179Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.35178286
180immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.35178286
181Fc-gamma receptor signaling pathway (GO:0038094)2.35178286
182positive regulation of neurotransmitter secretion (GO:0001956)2.34169446
183positive regulation of B cell proliferation (GO:0030890)2.34158989
184negative regulation of bone resorption (GO:0045779)2.33330280
185positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.32272723
186regulation of T cell receptor signaling pathway (GO:0050856)2.32143166
187interferon-gamma-mediated signaling pathway (GO:0060333)2.31231220
188prepulse inhibition (GO:0060134)2.31161516
189Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.29923148
190establishment of protein localization to Golgi (GO:0072600)2.29681660
191positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.27923403
192retrograde transport, vesicle recycling within Golgi (GO:0000301)2.27317908
193negative regulation of phagocytosis (GO:0050765)2.27135954
194mucosal-associated lymphoid tissue development (GO:0048537)2.27071416
195Peyers patch development (GO:0048541)2.27071416
196JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.26807973
197positive regulation of vesicle fusion (GO:0031340)2.26700069
198T cell migration (GO:0072678)2.26441311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.76062577
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.32946434
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.90908583
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.87744544
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.72239605
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.28946982
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15891045
8RUNX_20019798_ChIP-Seq_JUKART_Human2.73323636
9MYC_22102868_ChIP-Seq_BL_Human2.72665949
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69522865
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.62595499
12GATA1_22025678_ChIP-Seq_K562_Human2.59760401
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39017586
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.37832340
15IRF1_19129219_ChIP-ChIP_H3396_Human2.37536238
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30146915
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27420144
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26334745
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18444599
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15209468
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.07788157
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.07739578
23EZH2_22144423_ChIP-Seq_EOC_Human2.07089293
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05097119
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03864157
26AR_21572438_ChIP-Seq_LNCaP_Human2.00422775
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00280887
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.96459386
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.96295598
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92651985
31MYB_26560356_Chip-Seq_TH2_Human1.86448459
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86189630
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.85687716
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85103775
35CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80763488
36FUS_26573619_Chip-Seq_HEK293_Human1.80748527
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80726050
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.79491992
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79456549
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79270238
41KDM2B_26808549_Chip-Seq_DND41_Human1.77714718
42MAF_26560356_Chip-Seq_TH1_Human1.75468059
43TCF7_22412390_ChIP-Seq_EML_Mouse1.74191754
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.72603584
45GBX2_23144817_ChIP-Seq_PC3_Human1.69215567
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.67567923
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.63395041
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61914216
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61147753
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59220120
51ZNF274_21170338_ChIP-Seq_K562_Hela1.58535607
52UTX_26944678_Chip-Seq_JUKART_Human1.58354062
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57796125
54SPI1_23127762_ChIP-Seq_K562_Human1.57470600
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57081871
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56562950
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52864784
58SCL_19346495_ChIP-Seq_HPC-7_Human1.52842327
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52757599
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52463985
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51984503
62REST_21632747_ChIP-Seq_MESCs_Mouse1.51171222
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49587509
64MYB_26560356_Chip-Seq_TH1_Human1.49202423
65DROSHA_22980978_ChIP-Seq_HELA_Human1.47903955
66ER_23166858_ChIP-Seq_MCF-7_Human1.47689303
67VDR_21846776_ChIP-Seq_THP-1_Human1.45089114
68P300_19829295_ChIP-Seq_ESCs_Human1.44725087
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.41263226
70GATA3_27048872_Chip-Seq_THYMUS_Human1.40544637
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.39893003
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.39785011
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37410350
74STAT3_23295773_ChIP-Seq_U87_Human1.37263233
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.35804176
76VDR_24763502_ChIP-Seq_THP-1_Human1.35465236
77RXR_22108803_ChIP-Seq_LS180_Human1.34427208
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33049598
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32849618
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31364493
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29297486
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29297486
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28282015
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26625149
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26288214
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26272257
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25440293
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.25391032
89TCF4_23295773_ChIP-Seq_U87_Human1.22951041
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22247972
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21914696
92EWS_26573619_Chip-Seq_HEK293_Human1.21187363
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19530751
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.19007350
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18717277
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18138990
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17166723
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15205805
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14995068
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14918808
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.14824762
102RNF2_27304074_Chip-Seq_NSC_Mouse1.14322654
103SMAD4_21799915_ChIP-Seq_A2780_Human1.13998872
104TP53_18474530_ChIP-ChIP_U2OS_Human1.13857495
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13519882
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13430792
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.13146931
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12321172
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11537530
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11183974
111KDM2B_26808549_Chip-Seq_K562_Human1.10866365
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10691787
113TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10460113
114* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10166833
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09983398
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08827741
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08522411
118IGF1R_20145208_ChIP-Seq_DFB_Human1.08247432
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06932170
120EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06932170
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06902861
122BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06900172
123VDR_24787735_ChIP-Seq_THP-1_Human1.05883735
124TAF15_26573619_Chip-Seq_HEK293_Human1.05858756
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05640451
126FOXO3_23340844_ChIP-Seq_DLD1_Human1.03131823
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02418368
128GATA2_19941826_ChIP-Seq_K562_Human1.01704031
129POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01647665
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01533987
131AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01200061
132VDR_22108803_ChIP-Seq_LS180_Human1.01121080
133* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00881982
134CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00668884
135* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00489854
136* FOXA1_25329375_ChIP-Seq_VCAP_Human1.00489854
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00316205
138BCAT_22108803_ChIP-Seq_LS180_Human0.99914326
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99254365
140* RUNX1_22412390_ChIP-Seq_EML_Mouse0.98879213
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98635278
142GATA1_19941826_ChIP-Seq_K562_Human0.98397895
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98200367
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98053022
145TP53_16413492_ChIP-PET_HCT116_Human0.97944934
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97561396
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95173607
148TP53_23651856_ChIP-Seq_MEFs_Mouse0.94903818
149* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94480369
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.94286427
151TAF2_19829295_ChIP-Seq_ESCs_Human0.94086308
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.93897528
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93876396
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93484074
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92796347
156PU_27001747_Chip-Seq_BMDM_Mouse0.92324003
157AR_25329375_ChIP-Seq_VCAP_Human0.92109422
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92002061
159KDM2B_26808549_Chip-Seq_REH_Human0.91831208
160SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91279064
161* SMRT_27268052_Chip-Seq_Bcells_Human0.90606615
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89112423
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87881205
164LXR_22292898_ChIP-Seq_THP-1_Human0.87823221
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87649919
166AHR_22903824_ChIP-Seq_MCF-7_Human0.87516039
167JUN_21703547_ChIP-Seq_K562_Human0.87263243
168NANOG_16153702_ChIP-ChIP_HESCs_Human0.87121754
169NOTCH1_21737748_ChIP-Seq_TLL_Human0.86989684
170SOX2_21211035_ChIP-Seq_LN229_Gbm0.86821695
171NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86599343
172CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86500673
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.84484507
174MAF_26560356_Chip-Seq_TH2_Human0.83230385
175* PRDM14_20953172_ChIP-Seq_ESCs_Human0.82833330
176CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82245155
177RNF2_27304074_Chip-Seq_ESCs_Mouse0.80282733
178JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79934104
179ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79665267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis8.07413316
2MP0003646_muscle_fatigue7.90482992
3MP0004859_abnormal_synaptic_plasticity3.75805298
4MP0006292_abnormal_olfactory_placode3.27119542
5MP0003300_gastrointestinal_ulcer3.22212701
6MP0009053_abnormal_anal_canal3.09130197
7MP0003303_peritoneal_inflammation2.97815899
8MP0000537_abnormal_urethra_morphology2.94990524
9MP0001835_abnormal_antigen_presentation2.94609033
10MP0004185_abnormal_adipocyte_glucose2.92865736
11MP0001800_abnormal_humoral_immune2.92473094
12MP0001348_abnormal_lacrimal_gland2.90099377
13MP0001790_abnormal_immune_system2.90082008
14MP0005387_immune_system_phenotype2.90082008
15MP0010234_abnormal_vibrissa_follicle2.89363769
16MP0000569_abnormal_digit_pigmentation2.74170810
17MP0005646_abnormal_pituitary_gland2.60613331
18MP0000685_abnormal_immune_system2.46749198
19MP0002166_altered_tumor_susceptibility2.43188503
20MP0002160_abnormal_reproductive_system2.42682768
21MP0004510_myositis2.39689839
22MP0003567_abnormal_fetal_cardiomyocyte2.39605119
23MP0005671_abnormal_response_to2.36711127
24MP0005379_endocrine/exocrine_gland_phen2.35297148
25MP0002452_abnormal_antigen_presenting2.24569826
26MP0003763_abnormal_thymus_physiology2.22360287
27MP0003183_abnormal_peptide_metabolism2.19685043
28MP0003787_abnormal_imprinting2.16459840
29MP0009780_abnormal_chondrocyte_physiolo2.10210071
30MP0002420_abnormal_adaptive_immunity2.05029011
31MP0005000_abnormal_immune_tolerance2.03920667
32MP0003635_abnormal_synaptic_transmissio2.01715920
33MP0002653_abnormal_ependyma_morphology2.01161335
34MP0004142_abnormal_muscle_tone1.99972570
35MP0004145_abnormal_muscle_electrophysio1.99821549
36MP0001819_abnormal_immune_cell1.99525432
37MP0002723_abnormal_immune_serum1.98890042
38MP0004947_skin_inflammation1.98743154
39MP0005389_reproductive_system_phenotype1.96277316
40MP0002138_abnormal_hepatobiliary_system1.94100727
41MP0008775_abnormal_heart_ventricle1.93666723
42MP0004130_abnormal_muscle_cell1.93124154
43MP0002398_abnormal_bone_marrow1.91158764
44MP0009250_abnormal_appendicular_skeleto1.88351821
45MP0008961_abnormal_basal_metabolism1.83814659
46MP0002909_abnormal_adrenal_gland1.77013187
47MP0000383_abnormal_hair_follicle1.76232226
48MP0002822_catalepsy1.72898762
49MP0000049_abnormal_middle_ear1.69576026
50MP0002006_tumorigenesis1.69121539
51MP0003045_fibrosis1.65952603
52MP0008789_abnormal_olfactory_epithelium1.64203109
53MP0000716_abnormal_immune_system1.63809377
54MP0003937_abnormal_limbs/digits/tail_de1.62872188
55MP0006072_abnormal_retinal_apoptosis1.56797043
56MP0000631_abnormal_neuroendocrine_gland1.52746365
57MP0003011_delayed_dark_adaptation1.52164732
58MP0006054_spinal_hemorrhage1.51901658
59MP0008569_lethality_at_weaning1.50213017
60MP0004808_abnormal_hematopoietic_stem1.47002739
61MP0000689_abnormal_spleen_morphology1.46283412
62MP0001968_abnormal_touch/_nociception1.45472549
63MP0003880_abnormal_central_pattern1.44370956
64MP0009384_cardiac_valve_regurgitation1.41824396
65MP0002009_preneoplasia1.40964367
66MP0002102_abnormal_ear_morphology1.39806568
67MP0002063_abnormal_learning/memory/cond1.37135180
68MP0009745_abnormal_behavioral_response1.35495653
69MP0003866_abnormal_defecation1.34449079
70MP0002722_abnormal_immune_system1.34446738
71MP0001879_abnormal_lymphatic_vessel1.31585799
72MP0005408_hypopigmentation1.30257686
73MP0003436_decreased_susceptibility_to1.28113099
74MP0002419_abnormal_innate_immunity1.27897904
75MP0001873_stomach_inflammation1.27483067
76MP0001293_anophthalmia1.26789555
77MP0001501_abnormal_sleep_pattern1.26596545
78MP0000703_abnormal_thymus_morphology1.26328097
79MP0000465_gastrointestinal_hemorrhage1.26197936
80MP0005464_abnormal_platelet_physiology1.25365420
81MP0002429_abnormal_blood_cell1.24719396
82MP0000013_abnormal_adipose_tissue1.24425954
83MP0002064_seizures1.24142972
84MP0005025_abnormal_response_to1.23022554
85MP0003879_abnormal_hair_cell1.22874298
86MP0001919_abnormal_reproductive_system1.21664392
87MP0002139_abnormal_hepatobiliary_system1.21355776
88MP0005499_abnormal_olfactory_system1.21053506
89MP0005394_taste/olfaction_phenotype1.21053506
90MP0002933_joint_inflammation1.18019190
91MP0004019_abnormal_vitamin_homeostasis1.17881415
92MP0003119_abnormal_digestive_system1.14804195
93MP0005360_urolithiasis1.13874024
94MP0001666_abnormal_nutrient_absorption1.13552869
95MP0009785_altered_susceptibility_to1.13387704
96MP0004270_analgesia1.12549333
97MP0001485_abnormal_pinna_reflex1.11984999
98MP0002396_abnormal_hematopoietic_system1.11841465
99MP0005076_abnormal_cell_differentiation1.11116205
100MP0004885_abnormal_endolymph1.10597745
101MP0003938_abnormal_ear_development1.09256895
102MP0003075_altered_response_to1.07558845
103MP0008872_abnormal_physiological_respon1.07523334
104MP0002877_abnormal_melanocyte_morpholog1.07075521
105MP0002736_abnormal_nociception_after1.07011040
106MP0003091_abnormal_cell_migration1.04833005
107MP0000604_amyloidosis1.03939447
108MP0000778_abnormal_nervous_system1.02444609
109MP0003942_abnormal_urinary_system1.02279999
110MP0003633_abnormal_nervous_system1.01836252
111MP0010155_abnormal_intestine_physiology1.01534038
112MP0002572_abnormal_emotion/affect_behav1.01073972
113MP0000467_abnormal_esophagus_morphology1.00783107
114MP0005166_decreased_susceptibility_to1.00341388
115MP0002405_respiratory_system_inflammati0.99411774
116MP0001845_abnormal_inflammatory_respons0.99134472
117MP0002272_abnormal_nervous_system0.97536546
118MP0003690_abnormal_glial_cell0.96764810
119MP0002932_abnormal_joint_morphology0.96241738
120MP0002282_abnormal_trachea_morphology0.94608955
121MP0008874_decreased_physiological_sensi0.94209687
122MP0000427_abnormal_hair_cycle0.93666359
123MP0002638_abnormal_pupillary_reflex0.93331212
124MP0003172_abnormal_lysosome_physiology0.91717748
125MP0005174_abnormal_tail_pigmentation0.90238688
126MP0002148_abnormal_hypersensitivity_rea0.89696212
127MP0004811_abnormal_neuron_physiology0.88584340
128MP0000428_abnormal_craniofacial_morphol0.88039590
129MP0005551_abnormal_eye_electrophysiolog0.87531746
130MP0002928_abnormal_bile_duct0.86923791
131MP0005195_abnormal_posterior_eye0.86899034
132MP0001853_heart_inflammation0.85965443
133MP0004133_heterotaxia0.83837553
134MP0009046_muscle_twitch0.83500211
135MP0000026_abnormal_inner_ear0.83299382
136MP0003329_amyloid_beta_deposits0.82375251
137MP0002796_impaired_skin_barrier0.81950562
138MP0010368_abnormal_lymphatic_system0.81487456
139MP0002249_abnormal_larynx_morphology0.80692211
140MP0002089_abnormal_postnatal_growth/wei0.80319831
141MP0003279_aneurysm0.79038863
142MP0001851_eye_inflammation0.78397261
143MP0005423_abnormal_somatic_nervous0.78063432
144MP0003786_premature_aging0.76459229
145MP0002234_abnormal_pharynx_morphology0.75804661
146MP0000015_abnormal_ear_pigmentation0.74895345
147MP0000955_abnormal_spinal_cord0.74609143
148MP0002998_abnormal_bone_remodeling0.73790469
149MP0010352_gastrointestinal_tract_polyps0.73405177
150MP0002557_abnormal_social/conspecific_i0.73330470
151MP0003890_abnormal_embryonic-extraembry0.72191694
152MP0002734_abnormal_mechanical_nocicepti0.70786997
153MP0002735_abnormal_chemical_nociception0.70720991
154MP0002163_abnormal_gland_morphology0.70364013
155MP0005647_abnormal_sex_gland0.69167341
156MP0003136_yellow_coat_color0.68579790
157MP0010678_abnormal_skin_adnexa0.67617629
158MP0002184_abnormal_innervation0.67511485
159MP0003122_maternal_imprinting0.66190740
160MP0001440_abnormal_grooming_behavior0.65942108
161MP0005310_abnormal_salivary_gland0.65902514
162MP0001533_abnormal_skeleton_physiology0.65557971
163MP0002067_abnormal_sensory_capabilities0.65399489
164MP0003705_abnormal_hypodermis_morpholog0.65361469
165MP0005410_abnormal_fertilization0.65291551
166MP0002229_neurodegeneration0.65061995
167MP0000613_abnormal_salivary_gland0.64618706
168MP0002752_abnormal_somatic_nervous0.62700839
169MP0003631_nervous_system_phenotype0.62598837
170MP0002733_abnormal_thermal_nociception0.62497860
171MP0008877_abnormal_DNA_methylation0.61812877
172MP0001191_abnormal_skin_condition0.61065623
173MP0010771_integument_phenotype0.60828725
174MP0002876_abnormal_thyroid_physiology0.60229164
175MP0003453_abnormal_keratinocyte_physiol0.59300969
176MP0005386_behavior/neurological_phenoty0.58233736
177MP0004924_abnormal_behavior0.58233736
178MP0005666_abnormal_adipose_tissue0.57934538
179MP0005084_abnormal_gallbladder_morpholo0.56573028
180MP0003878_abnormal_ear_physiology0.56554452
181MP0005377_hearing/vestibular/ear_phenot0.56554452
182MP0001970_abnormal_pain_threshold0.56280120
183MP0001963_abnormal_hearing_physiology0.56158652
184MP0002098_abnormal_vibrissa_morphology0.55871648
185MP0003755_abnormal_palate_morphology0.55841693
186MP0005332_abnormal_amino_acid0.55794007
187MP0003936_abnormal_reproductive_system0.55577937
188MP0001286_abnormal_eye_development0.55309991

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the proximal phalanges of the hand (HP:0009834)6.30020676
2Abnormality of the middle phalanges of the toes (HP:0010183)5.17179930
3Agammaglobulinemia (HP:0004432)5.07072326
4Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.81091269
5Abnormality of the phalanges of the 5th finger (HP:0004213)4.55175861
6Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.26063101
7Verrucae (HP:0200043)4.16833750
8Papilloma (HP:0012740)4.16833750
9Fatigable weakness (HP:0003473)4.15247076
10Abnormality of the neuromuscular junction (HP:0003398)4.15247076
11Abnormality of the nasal septum (HP:0000419)4.13503931
12Fibular aplasia (HP:0002990)4.11150475
13Symphalangism affecting the phalanges of the hand (HP:0009773)4.10974151
14Osteomalacia (HP:0002749)4.02798712
15Hypoplasia of the uterus (HP:0000013)4.01083090
16Papilledema (HP:0001085)3.93925295
17Genetic anticipation (HP:0003743)3.85934797
18Gastrointestinal stroma tumor (HP:0100723)3.76729157
19Short hallux (HP:0010109)3.75402402
20Cellulitis (HP:0100658)3.74999793
21Recurrent bronchitis (HP:0002837)3.67230412
22Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.51668997
23Short 1st metacarpal (HP:0010034)3.51668997
24Aplasia/Hypoplasia of the hallux (HP:0008362)3.49097760
25Recurrent viral infections (HP:0004429)3.46493407
26Congenital stationary night blindness (HP:0007642)3.45619775
27Morphological abnormality of the middle ear (HP:0008609)3.45335214
28Colitis (HP:0002583)3.36292912
29Synostosis of carpal bones (HP:0005048)3.35055851
30Panhypogammaglobulinemia (HP:0003139)3.25893684
31Abnormality of the phalanges of the 2nd finger (HP:0009541)3.19988595
32Nephronophthisis (HP:0000090)3.16971001
33Humeroradial synostosis (HP:0003041)3.12262350
34Synostosis involving the elbow (HP:0003938)3.12262350
35Abnormality of the 1st metacarpal (HP:0010009)3.06310419
36Conjunctival hamartoma (HP:0100780)3.04356756
37Aplasia/hypoplasia of the uterus (HP:0008684)3.03548193
38Chronic otitis media (HP:0000389)2.96902164
39Gastrointestinal inflammation (HP:0004386)2.96259430
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.96237353
41Molar tooth sign on MRI (HP:0002419)2.96231492
42Abnormality of midbrain morphology (HP:0002418)2.96231492
43Inflammation of the large intestine (HP:0002037)2.95036450
44Mildly elevated creatine phosphokinase (HP:0008180)2.94389695
45True hermaphroditism (HP:0010459)2.87994588
46Absent phalangeal crease (HP:0006109)2.83511547
47Meningitis (HP:0001287)2.83020331
48Decreased subcutaneous fat (HP:0001002)2.80480808
49Short femoral neck (HP:0100864)2.79494171
50B lymphocytopenia (HP:0010976)2.73708303
51Abnormality of B cell number (HP:0010975)2.73708303
52Pendular nystagmus (HP:0012043)2.73597409
53Aplasia involving bones of the upper limbs (HP:0009823)2.72514143
54Aplasia of the phalanges of the hand (HP:0009802)2.72514143
55Aplasia involving bones of the extremities (HP:0009825)2.72514143
56IgM deficiency (HP:0002850)2.69596296
572-3 toe syndactyly (HP:0004691)2.67356676
58Vasculitis (HP:0002633)2.67220319
59Broad hallux (HP:0010055)2.66824024
60Progressive cerebellar ataxia (HP:0002073)2.66717871
61Emphysema (HP:0002097)2.65928837
62Lymphopenia (HP:0001888)2.65697292
63Chorioretinal atrophy (HP:0000533)2.65695423
64Pancreatic fibrosis (HP:0100732)2.65322952
65Pancreatic cysts (HP:0001737)2.65005713
66Hyperglycinemia (HP:0002154)2.62053610
67Focal motor seizures (HP:0011153)2.61332620
68T lymphocytopenia (HP:0005403)2.61264101
69Recurrent fungal infections (HP:0002841)2.60825732
70Aplasia/Hypoplasia of the fibula (HP:0006492)2.57176186
71Abnormality of the renal medulla (HP:0100957)2.55722455
72Chronic sinusitis (HP:0011109)2.55374504
73Erythroderma (HP:0001019)2.55016714
74Adrenal hypoplasia (HP:0000835)2.53255948
75Increased IgE level (HP:0003212)2.51972721
76Fatigue (HP:0012378)2.51641927
77Asplenia (HP:0001746)2.50908696
78Mitral stenosis (HP:0001718)2.47346076
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.46467813
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.46261031
81Recurrent sinusitis (HP:0011108)2.45963451
82Macroorchidism (HP:0000053)2.45958664
83Eczematoid dermatitis (HP:0000976)2.45881086
84Abnormality of T cell number (HP:0011839)2.45570580
85Septo-optic dysplasia (HP:0100842)2.44095156
86Striae distensae (HP:0001065)2.44037747
87Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.41431445
88Aortic aneurysm (HP:0004942)2.40922231
89Epileptic encephalopathy (HP:0200134)2.39865263
90Thyroiditis (HP:0100646)2.38742932
91Atonic seizures (HP:0010819)2.36936145
92Carpal synostosis (HP:0009702)2.36608341
93Stomach cancer (HP:0012126)2.34105989
94Focal seizures (HP:0007359)2.32695909
95Short phalanx of the thumb (HP:0009660)2.32517188
96Epidermoid cyst (HP:0200040)2.31103299
97Recurrent cutaneous fungal infections (HP:0011370)2.30097662
98Chronic mucocutaneous candidiasis (HP:0002728)2.30097662
99Methylmalonic acidemia (HP:0002912)2.28820312
100Osteomyelitis (HP:0002754)2.27838993
101Alveolar cell carcinoma (HP:0006519)2.27493159
102Abnormal finger flexion creases (HP:0006143)2.26593535
103Vertebral arch anomaly (HP:0008438)2.23996259
104Small epiphyses (HP:0010585)2.23551432
105Easy fatigability (HP:0003388)2.23404778
106Adactyly (HP:0009776)2.23188608
107Gaze-evoked nystagmus (HP:0000640)2.22282546
108Myokymia (HP:0002411)2.21626221
109Fragile nails (HP:0001808)2.20272836
110Cerebral aneurysm (HP:0004944)2.19917369
111Restrictive lung disease (HP:0002091)2.19873047
112Myositis (HP:0100614)2.19806379
113Broad toe (HP:0001837)2.19367831
114IgA deficiency (HP:0002720)2.18982583
115Abnormality of subcutaneous fat tissue (HP:0001001)2.18004677
116Synostosis involving bones of the hand (HP:0004278)2.17564644
117Proximal amyotrophy (HP:0007126)2.17469497
118Hemiplegia (HP:0002301)2.16302242
119Hyperlipoproteinemia (HP:0010980)2.14240331
120Arterial tortuosity (HP:0005116)2.13140885
121Oligodontia (HP:0000677)2.10865481
122Fused cervical vertebrae (HP:0002949)2.10081562
123Lower limb amyotrophy (HP:0007210)2.09623467
124Truncal ataxia (HP:0002078)2.08948226
125Furrowed tongue (HP:0000221)2.07348065
126Neoplasm of the tracheobronchial system (HP:0100552)2.07070330
127Abnormality of the distal phalanges of the toes (HP:0010182)2.06415864
128Abnormality of oral frenula (HP:0000190)2.06107989
129Methylmalonic aciduria (HP:0012120)2.05638074
130Resting tremor (HP:0002322)2.05259736
131Sepsis (HP:0100806)2.04913650
132Increased corneal curvature (HP:0100692)2.03750829
133Keratoconus (HP:0000563)2.03750829
134Dilatation of the ascending aorta (HP:0005111)2.03636031
135Abnormality of DNA repair (HP:0003254)2.02406887
136Confusion (HP:0001289)2.02370494
137Absent/shortened dynein arms (HP:0200106)2.01499596
138Dynein arm defect of respiratory motile cilia (HP:0012255)2.01499596
139Agitation (HP:0000713)2.01008112
140Tarsal synostosis (HP:0008368)1.99930580
141Waddling gait (HP:0002515)1.99921314
142Aplasia/Hypoplasia of the sternum (HP:0006714)1.98982812
143Abnormality of T cells (HP:0002843)1.98371276
144Absent frontal sinuses (HP:0002688)1.98031501
145Viral hepatitis (HP:0006562)1.97977506
146Visual hallucinations (HP:0002367)1.97616659
147Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.97429720
148Arterial thrombosis (HP:0004420)1.97287938
149Recurrent bacterial skin infections (HP:0005406)1.96390893
150Megalencephaly (HP:0001355)1.96282323
151Hemiparesis (HP:0001269)1.95827858
152Abnormality of the 2nd finger (HP:0004100)1.95697622
153Pulmonary infiltrates (HP:0002113)1.95465182
154Abnormality of the costochondral junction (HP:0000919)1.95387938
155Cystic liver disease (HP:0006706)1.94072333
156Elevated erythrocyte sedimentation rate (HP:0003565)1.93739859
157Increased density of long bones (HP:0006392)1.92195174
158Bile duct proliferation (HP:0001408)1.91973749
159Abnormal biliary tract physiology (HP:0012439)1.91973749
160Abnormal rod and cone electroretinograms (HP:0008323)1.91960431
161Volvulus (HP:0002580)1.91596614
162Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.90833540
163Recurrent otitis media (HP:0000403)1.90504493
164Acrocyanosis (HP:0001063)1.89920730
165IgG deficiency (HP:0004315)1.87589350
166Mitral valve prolapse (HP:0001634)1.86321404
167Ankyloglossia (HP:0010296)1.85578456
168Autoimmune thrombocytopenia (HP:0001973)1.84958613
169Distal lower limb amyotrophy (HP:0008944)1.84806074
170Aortic dissection (HP:0002647)1.83920126
171Abnormality of binocular vision (HP:0011514)1.83116596
172Diplopia (HP:0000651)1.83116596
173Recurrent abscess formation (HP:0002722)1.82623052
174Vascular tortuosity (HP:0004948)1.81888152
175Mediastinal lymphadenopathy (HP:0100721)1.81373917
176Stomatitis (HP:0010280)1.80321276
177Recurrent lower respiratory tract infections (HP:0002783)1.79509555
178Recurrent pneumonia (HP:0006532)1.78918525
179Optic neuritis (HP:0100653)1.77701769
180Retrobulbar optic neuritis (HP:0100654)1.77701769
181Aortic regurgitation (HP:0001659)1.75705698
182Febrile seizures (HP:0002373)1.72350971
183Hematochezia (HP:0002573)1.71443168
184Chest pain (HP:0100749)1.70937594
185Recurrent skin infections (HP:0001581)1.68874724
186Bronchitis (HP:0012387)1.68657533
187Keratoconjunctivitis sicca (HP:0001097)1.68602228
188Hamartoma of the eye (HP:0010568)1.67855518
189Abnormal foot bone ossification (HP:0010675)1.66253709
190Orchitis (HP:0100796)1.64928842
191Interstitial pulmonary disease (HP:0006530)1.64846613
192Urinary urgency (HP:0000012)1.64129939
193Impaired smooth pursuit (HP:0007772)1.64111089
194Dysmetric saccades (HP:0000641)1.63143532
195Inappropriate behavior (HP:0000719)1.62746891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.34569941
2MAPKAPK33.99776206
3PINK13.16395730
4GRK13.13645129
5MAP3K132.70138948
6GRK62.64687764
7RIPK42.59768467
8PLK22.48871393
9ERN12.33922949
10MAP3K102.23856114
11WNK32.23106033
12DAPK22.22312869
13FLT32.17961998
14MAP3K92.09419686
15SYK2.03719917
16JAK11.96794991
17SCYL21.87206470
18NTRK31.86338998
19PRKCH1.81568704
20ADRBK21.80492747
21CASK1.76363996
22EPHA41.74190940
23WNK41.73758027
24CAMK1D1.73667431
25TRIB31.68412476
26SIK21.62451997
27MAP3K141.57766426
28JAK31.53995918
29FES1.53788553
30EPHB21.52632132
31LRRK21.49343353
32ZAP701.43083235
33STK101.42047452
34RPS6KA21.41392901
35INSRR1.39977738
36PKN21.38688328
37FGFR31.37161324
38CSF1R1.37111516
39ITK1.36357212
40EEF2K1.36285899
41MAP3K121.34907595
42ACVR1B1.32618550
43PRKAA11.32118608
44RPS6KA61.31689918
45BMPR1B1.31488545
46TGFBR21.28602205
47CAMK2B1.27815403
48CAMKK11.27749389
49MAP3K71.26411193
50TAOK11.25030490
51HCK1.24762669
52TYK21.24342585
53TNK21.20147496
54DYRK21.18301630
55CCNB11.16994291
56MAPK131.15474078
57PRKCQ1.14138256
58CSK1.13191165
59CAMKK21.12115262
60BTK1.10576659
61TXK1.08854103
62FGFR41.03136140
63DYRK31.02740235
64PRKCE1.00059331
65CAMK2A0.99780440
66GRK50.98682289
67SGK30.97628774
68NTRK20.95723607
69PRKCG0.95397155
70ZAK0.94706969
71ADRBK10.94439681
72MAP3K30.94392784
73SGK2230.94363755
74SGK4940.94363755
75PIK3CA0.93952921
76RET0.93194215
77PDK10.91761242
78STK390.91026051
79MAPK120.90652389
80MINK10.88987350
81INSR0.88515213
82KIT0.88200009
83DMPK0.88019167
84MAP2K70.87866004
85MAP3K20.87180334
86MAP3K40.86326708
87CDK190.86221100
88MARK20.86061974
89KSR20.84337926
90TNIK0.84317177
91PRKD20.84313203
92RPS6KL10.84299082
93RPS6KC10.84299082
94MARK10.83260633
95CDC42BPA0.81805851
96BLK0.81766724
97JAK20.81440251
98AURKA0.81117126
99ABL20.80897321
100CDK50.80724133
101MARK30.80412371
102PRKCI0.79757254
103LCK0.79503629
104RAF10.79310585
105STK160.79239011
106LYN0.78569398
107FRK0.78479115
108CDK90.78415461
109KSR10.78414345
110DYRK1A0.78047065
111MAPK70.77506149
112MKNK20.76252117
113PRKCZ0.75286902
114ALK0.74602819
115MAP2K40.73028924
116CSNK1G20.72474024
117DAPK10.71989594
118TEC0.71665712
119HIPK20.71322457
120PRKACA0.71057473
121MST40.70764609
122ERBB20.70505110
123MAP3K10.70304592
124LIMK10.70254217
125TBK10.69832903
126FGFR20.69333569
127MAP2K20.67679787
128FYN0.67164278
129PRKACG0.66887125
130PAK60.66781525
131CSNK1A10.65961037
132MAP2K30.64752438
133PTK60.61631200
134TLK10.61275925
135MAPK90.61042000
136SGK20.60806478
137BRSK10.60094347
138STK380.58429978
139STK110.57095164
140TRPM70.55068169
141RPS6KA40.53063827
142GRK70.52149059
143IKBKB0.51489137
144CLK10.50887246
145NUAK10.49373095
146CDC70.47916918
147MAPK80.47271524
148IKBKE0.47058837
149PRKCA0.46927140
150CAMK10.46411059
151TTN0.46290799
152PTK2B0.46273719
153STK240.45623102
154PRKD30.44972221
155PHKG20.43513944
156PHKG10.43513944
157OXSR10.43158907
158MAPK110.43122151
159MELK0.42774206
160CAMK1G0.42689130
161CDK60.42527593
162CHUK0.42027361
163MAP4K20.41335684
164STK38L0.41272616
165SGK10.41193090
166FGR0.40411941
167NEK90.40039760
168PRKD10.39854584
169PAK30.39818438
170BMPR20.39799913
171CHEK20.39038501
172PRKCD0.38863544
173GSK3B0.38619711
174FER0.36918100
175TYRO30.32937987
176RPS6KA10.32859050

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.87235700
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.37918304
3Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002503.23068513
4Sulfur metabolism_Homo sapiens_hsa009203.18418340
5Primary immunodeficiency_Homo sapiens_hsa053402.80515764
6B cell receptor signaling pathway_Homo sapiens_hsa046622.77466229
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.72355594
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.63888039
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32189635
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.24561076
11Retinol metabolism_Homo sapiens_hsa008302.24038655
12Phototransduction_Homo sapiens_hsa047442.10762005
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00445378
14Chemical carcinogenesis_Homo sapiens_hsa052041.98665023
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97950395
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90223775
17Olfactory transduction_Homo sapiens_hsa047401.85254665
18Long-term potentiation_Homo sapiens_hsa047201.81549507
19T cell receptor signaling pathway_Homo sapiens_hsa046601.75443414
20Nitrogen metabolism_Homo sapiens_hsa009101.71270651
21Histidine metabolism_Homo sapiens_hsa003401.67682558
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61959912
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61501647
24Osteoclast differentiation_Homo sapiens_hsa043801.60380278
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.59185497
26Starch and sucrose metabolism_Homo sapiens_hsa005001.53190528
27Renin secretion_Homo sapiens_hsa049241.48137546
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46252570
29Amphetamine addiction_Homo sapiens_hsa050311.43489409
30Glioma_Homo sapiens_hsa052141.41920269
31Salivary secretion_Homo sapiens_hsa049701.41498183
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41352008
33Synaptic vesicle cycle_Homo sapiens_hsa047211.41108571
34Circadian entrainment_Homo sapiens_hsa047131.39833190
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39671697
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39671347
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39315900
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38309565
39Morphine addiction_Homo sapiens_hsa050321.37456985
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.34865665
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.32648074
42Non-small cell lung cancer_Homo sapiens_hsa052231.31840165
43Glycerolipid metabolism_Homo sapiens_hsa005611.29040135
44Dopaminergic synapse_Homo sapiens_hsa047281.28811096
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.27768942
46Homologous recombination_Homo sapiens_hsa034401.26488235
47Oxytocin signaling pathway_Homo sapiens_hsa049211.24770314
48Platelet activation_Homo sapiens_hsa046111.23726081
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22910069
50Hematopoietic cell lineage_Homo sapiens_hsa046401.21255871
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.20645633
52Chemokine signaling pathway_Homo sapiens_hsa040621.20405159
53Hedgehog signaling pathway_Homo sapiens_hsa043401.19174398
54Chronic myeloid leukemia_Homo sapiens_hsa052201.19060347
55Pancreatic cancer_Homo sapiens_hsa052121.19039315
56Glutamatergic synapse_Homo sapiens_hsa047241.17981260
57Gastric acid secretion_Homo sapiens_hsa049711.17803932
58Nicotine addiction_Homo sapiens_hsa050331.16941223
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14713879
60Cholinergic synapse_Homo sapiens_hsa047251.14542273
61Basal cell carcinoma_Homo sapiens_hsa052171.14402045
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.12586947
63GnRH signaling pathway_Homo sapiens_hsa049121.11897056
64RNA polymerase_Homo sapiens_hsa030201.10389897
65Insulin secretion_Homo sapiens_hsa049111.08143216
66Type II diabetes mellitus_Homo sapiens_hsa049301.07134537
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06752456
68Sulfur relay system_Homo sapiens_hsa041221.05824294
69One carbon pool by folate_Homo sapiens_hsa006701.05170782
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04799058
71Tuberculosis_Homo sapiens_hsa051521.04098439
72Taste transduction_Homo sapiens_hsa047421.04071519
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04057413
74VEGF signaling pathway_Homo sapiens_hsa043701.03925748
75cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03630497
76Cardiac muscle contraction_Homo sapiens_hsa042601.02903205
77Leishmaniasis_Homo sapiens_hsa051401.02508627
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01835885
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00204060
80GABAergic synapse_Homo sapiens_hsa047270.99818772
81Linoleic acid metabolism_Homo sapiens_hsa005910.98826722
82Hepatitis B_Homo sapiens_hsa051610.97675733
83Estrogen signaling pathway_Homo sapiens_hsa049150.97240926
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96761466
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96114281
86MAPK signaling pathway_Homo sapiens_hsa040100.95941779
87Cocaine addiction_Homo sapiens_hsa050300.95563506
88Caffeine metabolism_Homo sapiens_hsa002320.95524626
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95429231
90Calcium signaling pathway_Homo sapiens_hsa040200.95391516
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.95157908
92Nucleotide excision repair_Homo sapiens_hsa034200.95009721
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94792003
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94704266
95Fat digestion and absorption_Homo sapiens_hsa049750.93934328
96cAMP signaling pathway_Homo sapiens_hsa040240.91436334
97Tryptophan metabolism_Homo sapiens_hsa003800.91103216
98Axon guidance_Homo sapiens_hsa043600.89995721
99Antigen processing and presentation_Homo sapiens_hsa046120.88990819
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88982266
101mTOR signaling pathway_Homo sapiens_hsa041500.88749039
102Long-term depression_Homo sapiens_hsa047300.87023205
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86534229
104Toxoplasmosis_Homo sapiens_hsa051450.86378889
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.85608273
106Endocytosis_Homo sapiens_hsa041440.85356399
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84727129
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83283321
109Measles_Homo sapiens_hsa051620.82156402
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81970153
111Inositol phosphate metabolism_Homo sapiens_hsa005620.81871911
112TNF signaling pathway_Homo sapiens_hsa046680.81619127
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81291373
114TGF-beta signaling pathway_Homo sapiens_hsa043500.80726198
115Dorso-ventral axis formation_Homo sapiens_hsa043200.80711187
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80599785
117Butanoate metabolism_Homo sapiens_hsa006500.79430112
118ErbB signaling pathway_Homo sapiens_hsa040120.78369220
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.78187154
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.77928386
121Gap junction_Homo sapiens_hsa045400.76798899
122Shigellosis_Homo sapiens_hsa051310.76344884
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.76338649
124Prolactin signaling pathway_Homo sapiens_hsa049170.75143894
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74960430
126Serotonergic synapse_Homo sapiens_hsa047260.74626034
127Melanoma_Homo sapiens_hsa052180.73272818
128Fanconi anemia pathway_Homo sapiens_hsa034600.72283497
129Insulin resistance_Homo sapiens_hsa049310.71323045
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70042563
131Colorectal cancer_Homo sapiens_hsa052100.69314787
132Proteoglycans in cancer_Homo sapiens_hsa052050.68911400
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68431062
134Acute myeloid leukemia_Homo sapiens_hsa052210.66884635
135Rap1 signaling pathway_Homo sapiens_hsa040150.65768913
136African trypanosomiasis_Homo sapiens_hsa051430.65615321
137Viral myocarditis_Homo sapiens_hsa054160.63530408
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.62788389
139Endometrial cancer_Homo sapiens_hsa052130.62275726
140RNA degradation_Homo sapiens_hsa030180.61890844
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61830945
142Hepatitis C_Homo sapiens_hsa051600.61643981
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.61363209
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61314528
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61264759
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61264757
147Apoptosis_Homo sapiens_hsa042100.60928879
148FoxO signaling pathway_Homo sapiens_hsa040680.60777218
149Selenocompound metabolism_Homo sapiens_hsa004500.60270374
150Pancreatic secretion_Homo sapiens_hsa049720.59403722
151Alcoholism_Homo sapiens_hsa050340.57198054
152Choline metabolism in cancer_Homo sapiens_hsa052310.57086009
153Ras signaling pathway_Homo sapiens_hsa040140.56217164
154Hippo signaling pathway_Homo sapiens_hsa043900.56171970
155Renal cell carcinoma_Homo sapiens_hsa052110.55781006
156Tyrosine metabolism_Homo sapiens_hsa003500.52136646
157Systemic lupus erythematosus_Homo sapiens_hsa053220.43437277
158Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43434036
159Peroxisome_Homo sapiens_hsa041460.42230903
160Dilated cardiomyopathy_Homo sapiens_hsa054140.40875593
161Basal transcription factors_Homo sapiens_hsa030220.40862738
162Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40399177
163Bile secretion_Homo sapiens_hsa049760.39387561
164Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36780183
165Regulation of autophagy_Homo sapiens_hsa041400.35265723
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33071632
167Metabolic pathways_Homo sapiens_hsa011000.31211566
168MicroRNAs in cancer_Homo sapiens_hsa052060.31015023
169Ether lipid metabolism_Homo sapiens_hsa005650.30096450
170Pyrimidine metabolism_Homo sapiens_hsa002400.25246258
171Melanogenesis_Homo sapiens_hsa049160.24552693
172ECM-receptor interaction_Homo sapiens_hsa045120.23816496
173Wnt signaling pathway_Homo sapiens_hsa043100.22030730

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