TTLL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.84575872
2binding of sperm to zona pellucida (GO:0007339)9.74264532
3plasma membrane fusion (GO:0045026)9.69521464
4cell-cell recognition (GO:0009988)9.62848695
5motile cilium assembly (GO:0044458)9.58941943
6spermatid development (GO:0007286)9.39468758
7reproduction (GO:0000003)8.86588259
8cilium movement (GO:0003341)8.65662673
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.77777479
10sperm capacitation (GO:0048240)7.38957392
11single fertilization (GO:0007338)7.28620866
12male meiosis (GO:0007140)7.15922204
13piRNA metabolic process (GO:0034587)7.05508628
14synaptonemal complex organization (GO:0070193)7.03407774
15synaptonemal complex assembly (GO:0007130)6.72652966
16negative regulation of inclusion body assembly (GO:0090084)6.60687573
17organic cation transport (GO:0015695)6.38861976
18spermatogenesis (GO:0007283)6.28902045
19male gamete generation (GO:0048232)6.26461331
20fertilization (GO:0009566)6.23886988
21microtubule depolymerization (GO:0007019)5.99482850
22regulation of microtubule-based movement (GO:0060632)5.92009695
23gamete generation (GO:0007276)5.76815261
24microtubule bundle formation (GO:0001578)5.56945836
25male meiosis I (GO:0007141)5.49549711
26calcium ion-dependent exocytosis (GO:0017156)5.39423442
27regulation of inclusion body assembly (GO:0090083)5.29338065
28germ cell development (GO:0007281)5.21677241
29primary alcohol catabolic process (GO:0034310)5.18499568
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.17220837
31ventricular system development (GO:0021591)5.16357368
32microtubule severing (GO:0051013)5.13349928
33one-carbon compound transport (GO:0019755)4.81411172
34vitamin transmembrane transport (GO:0035461)4.77393279
35left/right pattern formation (GO:0060972)4.66592512
36multicellular organismal reproductive process (GO:0048609)4.58465766
37cell recognition (GO:0008037)4.57649141
38response to pheromone (GO:0019236)4.57196665
39ethanol metabolic process (GO:0006067)4.49670967
40negative regulation of T cell differentiation in thymus (GO:0033085)4.48762081
41DNA methylation involved in gamete generation (GO:0043046)4.47449701
42meiosis I (GO:0007127)4.45439664
43protein polyglutamylation (GO:0018095)4.43766954
44chromosome organization involved in meiosis (GO:0070192)4.39611095
45diterpenoid biosynthetic process (GO:0016102)4.38382705
46glycerol ether metabolic process (GO:0006662)4.30297343
47meiotic nuclear division (GO:0007126)4.24288229
48seminiferous tubule development (GO:0072520)4.04355376
49spermatid nucleus differentiation (GO:0007289)4.00669443
50chromosome condensation (GO:0030261)3.99125080
51glomerular epithelial cell development (GO:0072310)3.96813531
52ether metabolic process (GO:0018904)3.95744207
53pyrimidine-containing compound transmembrane transport (GO:0072531)3.91159704
54lung epithelium development (GO:0060428)3.89070792
55DNA packaging (GO:0006323)3.87622514
56phosphatidylethanolamine biosynthetic process (GO:0006646)3.79727802
57multicellular organismal development (GO:0007275)3.77342939
58establishment of apical/basal cell polarity (GO:0035089)3.74342759
59cell projection assembly (GO:0030031)3.72614993
60intraciliary transport (GO:0042073)3.71644034
61tolerance induction (GO:0002507)3.70324305
62phosphatidylethanolamine metabolic process (GO:0046337)3.57749093
63response to xenobiotic stimulus (GO:0009410)3.56428017
64polyol catabolic process (GO:0046174)3.53686411
65protein localization to cilium (GO:0061512)3.53524053
66regulation of interleukin-13 production (GO:0032656)3.52863341
67establishment or maintenance of monopolar cell polarity (GO:0061339)3.49893221
68establishment of monopolar cell polarity (GO:0061162)3.49893221
69ethanol oxidation (GO:0006069)3.47476326
70genitalia morphogenesis (GO:0035112)3.46546105
71lactate metabolic process (GO:0006089)3.46182539
72cellular ketone body metabolic process (GO:0046950)3.45868076
73meiotic cell cycle (GO:0051321)3.44341330
74chaperone-mediated protein complex assembly (GO:0051131)3.42701352
75retinoic acid metabolic process (GO:0042573)3.42663778
76interferon-gamma secretion (GO:0072643)3.39523195
77regulation of interleukin-5 production (GO:0032674)3.39158961
78axoneme assembly (GO:0035082)3.37442468
79terpenoid biosynthetic process (GO:0016114)3.36246993
80cilium organization (GO:0044782)3.29521781
81centriole assembly (GO:0098534)3.25365668
82regulation of spindle checkpoint (GO:0090231)3.24790064
83cilium assembly (GO:0042384)3.21698148
84exogenous drug catabolic process (GO:0042738)3.18922775
85protein refolding (GO:0042026)3.18118972
86carnitine transport (GO:0015879)3.17012514
87amino-acid betaine transport (GO:0015838)3.17012514
88RNA localization (GO:0006403)3.11111272
89monoubiquitinated protein deubiquitination (GO:0035520)3.09158652
90cilium morphogenesis (GO:0060271)3.08283761
91cytoplasmic microtubule organization (GO:0031122)3.06429377
92ketone body metabolic process (GO:1902224)3.04720066
93establishment of planar polarity (GO:0001736)3.02206376
94establishment of tissue polarity (GO:0007164)3.02206376
95microtubule polymerization or depolymerization (GO:0031109)3.00735927
96peptidyl-glutamic acid modification (GO:0018200)2.98772421
97microtubule-based movement (GO:0007018)2.98374363
98smoothened signaling pathway (GO:0007224)2.97070719
99regulation of germinal center formation (GO:0002634)2.96318839
100lateral ventricle development (GO:0021670)2.96028676
101negative regulation of B cell mediated immunity (GO:0002713)2.94781226
102negative regulation of immunoglobulin mediated immune response (GO:0002890)2.94781226
103gene silencing by RNA (GO:0031047)2.93522403
104sexual reproduction (GO:0019953)2.93507639
105nucleoside diphosphate phosphorylation (GO:0006165)2.93189028
106carnitine transmembrane transport (GO:1902603)2.92531891
107cellular component assembly involved in morphogenesis (GO:0010927)2.89437317
108nucleus organization (GO:0006997)2.89036826
109spinal cord motor neuron differentiation (GO:0021522)2.88425871
110regulation of chromatin binding (GO:0035561)2.85006298
111single strand break repair (GO:0000012)2.81585877
112glycolytic process (GO:0006096)2.80907494
113nonmotile primary cilium assembly (GO:0035058)2.78779872
114mitotic sister chromatid cohesion (GO:0007064)2.77474274
115alditol metabolic process (GO:0019400)2.77390408
116left/right axis specification (GO:0070986)2.74970305
117photoreceptor cell maintenance (GO:0045494)2.74412158
118RNA destabilization (GO:0050779)2.74129166
119determination of left/right symmetry (GO:0007368)2.72036030
120meiotic cell cycle process (GO:1903046)2.71218547
121aldehyde catabolic process (GO:0046185)2.71165245
122centriole replication (GO:0007099)2.64826994
123phosphatidylcholine biosynthetic process (GO:0006656)2.64589496
124regulation of cilium assembly (GO:1902017)2.63247310
125positive regulation of tolerance induction (GO:0002645)2.61882764
126phenol-containing compound catabolic process (GO:0019336)2.60688451
127retinol metabolic process (GO:0042572)2.59448439
128primary alcohol metabolic process (GO:0034308)2.58494880
129GTP biosynthetic process (GO:0006183)2.58400538
130hydrogen peroxide biosynthetic process (GO:0050665)2.57858236
131drug catabolic process (GO:0042737)2.57798194
132sequestering of actin monomers (GO:0042989)2.57198871
133determination of bilateral symmetry (GO:0009855)2.55118767
134negative regulation of humoral immune response (GO:0002921)2.52924443
135protein K11-linked deubiquitination (GO:0035871)2.52755763
136cornea development in camera-type eye (GO:0061303)2.52415458
137glutathione derivative metabolic process (GO:1901685)2.51808502
138glutathione derivative biosynthetic process (GO:1901687)2.51808502
139gene silencing (GO:0016458)2.51373501
140organelle assembly (GO:0070925)2.49260683
141oocyte development (GO:0048599)2.47607320
142mitochondrion degradation (GO:0000422)2.42832001
143sperm motility (GO:0030317)13.2151615
144fusion of sperm to egg plasma membrane (GO:0007342)12.8336445
145acrosome reaction (GO:0007340)12.0429350
146sperm-egg recognition (GO:0035036)10.7903890
147axonemal dynein complex assembly (GO:0070286)10.6858558
148cell wall macromolecule catabolic process (GO:0016998)10.6150708
149cell wall macromolecule metabolic process (GO:0044036)10.6150708
150multicellular organism reproduction (GO:0032504)10.5603986
151epithelial cilium movement (GO:0003351)10.1546092
152cilium or flagellum-dependent cell motility (GO:0001539)10.1093346
153regulation of cilium movement (GO:0003352)10.0901899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.80347685
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.82716274
3EZH2_22144423_ChIP-Seq_EOC_Human5.18202573
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.56495461
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32598558
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.23801849
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80893251
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71927091
9VDR_22108803_ChIP-Seq_LS180_Human2.56684118
10DROSHA_22980978_ChIP-Seq_HELA_Human2.52652374
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47398264
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22137361
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.13434964
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87626941
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86861276
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84847501
17WDR5_24793694_ChIP-Seq_LNCAP_Human1.81472759
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73477769
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72717505
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71955199
21STAT1_17558387_ChIP-Seq_HELA_Human1.68956554
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.63376586
23TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62992209
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.61034546
25* ETV1_20927104_ChIP-Seq_GIST48_Human1.60965724
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60030904
27ZNF274_21170338_ChIP-Seq_K562_Hela1.58216649
28ERA_21632823_ChIP-Seq_H3396_Human1.56880897
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56112102
30SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55432357
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50093158
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.49906951
33* PHF8_20622853_ChIP-Seq_HELA_Human1.49674674
34GATA3_21867929_ChIP-Seq_CD8_Mouse1.49102069
35* RBPJ_21746931_ChIP-Seq_IB4_Human1.48743307
36STAT1_20625510_ChIP-Seq_HELA_Human1.47939849
37ER_23166858_ChIP-Seq_MCF-7_Human1.47596345
38RUNX1_26923725_Chip-Seq_HPCs_Mouse1.45957278
39* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.45674408
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45658785
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45060221
42MYC_19829295_ChIP-Seq_ESCs_Human1.44833674
43KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44041487
44* HNFA_21074721_ChIP-Seq_CACO-2_Human1.43682147
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.42864254
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40720745
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40659446
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40433926
49CBP_20019798_ChIP-Seq_JUKART_Human1.40433926
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39361318
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.39361318
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.38544283
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38305421
54E2F1_20622854_ChIP-Seq_HELA_Human1.35835725
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35135423
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.34881442
57FUS_26573619_Chip-Seq_HEK293_Human1.34671071
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.34300369
59OCT4_20526341_ChIP-Seq_ESCs_Human1.34290517
60KDM2B_26808549_Chip-Seq_REH_Human1.34253794
61TAF2_19829295_ChIP-Seq_ESCs_Human1.33923059
62* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33573698
63CTCF_27219007_Chip-Seq_Bcells_Human1.33510310
64* GATA6_21074721_ChIP-Seq_CACO-2_Human1.33467772
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.33358075
66TAF15_26573619_Chip-Seq_HEK293_Human1.33257568
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33062472
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33062472
69PHF8_20622854_ChIP-Seq_HELA_Human1.32501069
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31940910
71* SMC4_20622854_ChIP-Seq_HELA_Human1.31718118
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30878037
73* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30796923
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29075253
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29074264
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.28904922
77P300_27268052_Chip-Seq_Bcells_Human1.28618586
78NCOR_22424771_ChIP-Seq_293T_Human1.27355721
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26964329
80P68_20966046_ChIP-Seq_HELA_Human1.26719988
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.26578671
82TP63_22573176_ChIP-Seq_HFKS_Human1.26516017
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26460907
84GF1_26923725_Chip-Seq_HPCs_Mouse1.25789933
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24436997
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.24362495
87SMRT_27268052_Chip-Seq_Bcells_Human1.24270002
88P53_21459846_ChIP-Seq_SAOS-2_Human1.24044738
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23802589
90* NFYB_21822215_ChIP-Seq_K562_Human1.23408931
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22976038
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22971055
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22053397
94* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.21432207
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20145987
96BCL6_27268052_Chip-Seq_Bcells_Human1.18963459
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18614013
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18434143
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17901521
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.16458580
101* NFYA_21822215_ChIP-Seq_K562_Human1.16414870
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15926165
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13966047
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13831839
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13437564
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13249447
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12806458
108ERG_20517297_ChIP-Seq_VCAP_Human1.12781468
109AR_20517297_ChIP-Seq_VCAP_Human1.12662030
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11961597
111AHR_22903824_ChIP-Seq_MCF-7_Human1.11570375
112* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11289087
113SMAD4_21799915_ChIP-Seq_A2780_Human1.10939679
114AR_21572438_ChIP-Seq_LNCaP_Human1.10520835
115CEBPB_22108803_ChIP-Seq_LS180_Human1.09873030
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08968486
117* TBL1_22424771_ChIP-Seq_293T_Human1.08903656
118ESET_19884257_ChIP-Seq_ESCs_Mouse1.08178973
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07713405
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07622191
121NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06810750
122AR_25329375_ChIP-Seq_VCAP_Human1.06218460
123RNF2_27304074_Chip-Seq_NSC_Mouse1.05429234
124GATA3_21867929_ChIP-Seq_TH1_Mouse1.04614058
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04235651
126SOX2_19829295_ChIP-Seq_ESCs_Human1.04148705
127NANOG_19829295_ChIP-Seq_ESCs_Human1.04148705
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04078349
129MYC_27129775_Chip-Seq_CORNEA_Mouse1.03647430
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03215974
131REST_21632747_ChIP-Seq_MESCs_Mouse1.02853383
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02005973
133HOXB7_26014856_ChIP-Seq_BT474_Human1.01747080
134P300_19829295_ChIP-Seq_ESCs_Human1.00547030
135BCOR_27268052_Chip-Seq_Bcells_Human1.00346418
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99965258
137STAT3_23295773_ChIP-Seq_U87_Human0.99887015
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99815888
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99646116
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99143933
141RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99133145
142STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97059959
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96699271
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96582620
145SPI1_26923725_Chip-Seq_HPCs_Mouse0.95942886
146JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95887769
147SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95766497
148OCT4_18555785_Chip-Seq_ESCs_Mouse0.95753768
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95177007
150SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94047921
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.93826462
152PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93573145
153CTCF_20526341_ChIP-Seq_ESCs_Human0.93536901
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93492220
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.93354108
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91862260
157* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91808055
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91292368
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91271234
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.91026203
161P53_22387025_ChIP-Seq_ESCs_Mouse0.89578893
162GF1B_26923725_Chip-Seq_HPCs_Mouse0.89368566
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.88658686
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87370018
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.87106161
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.87050525
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.86503483
168NANOG_20526341_ChIP-Seq_ESCs_Human0.85859449
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85711296
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85276049
171SOX2_21211035_ChIP-Seq_LN229_Human0.84329591
172OCT1_27270436_Chip-Seq_PROSTATE_Human0.83361389
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.82031744
174P300_18555785_Chip-Seq_ESCs_Mouse0.81899199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.70756444
2MP0001929_abnormal_gametogenesis5.08039874
3MP0008877_abnormal_DNA_methylation3.51141191
4MP0002210_abnormal_sex_determination3.31243818
5MP0002161_abnormal_fertility/fecundity3.16473166
6MP0002277_abnormal_respiratory_mucosa2.88441257
7MP0004133_heterotaxia2.85294938
8MP0001145_abnormal_male_reproductive2.84708193
9MP0002653_abnormal_ependyma_morphology2.65503362
10MP0005670_abnormal_white_adipose2.49916599
11MP0000653_abnormal_sex_gland2.47511606
12MP0002160_abnormal_reproductive_system2.30912039
13MP0005410_abnormal_fertilization15.2220957
14MP0001984_abnormal_olfaction1.93783870
15MP0009780_abnormal_chondrocyte_physiolo1.93056108
16MP0005646_abnormal_pituitary_gland1.88427415
17MP0000566_synostosis1.88009963
18MP0005623_abnormal_meninges_morphology1.79966324
19MP0000678_abnormal_parathyroid_gland1.74427193
20MP0001765_abnormal_ion_homeostasis1.64180322
21MP0003878_abnormal_ear_physiology1.60780102
22MP0005377_hearing/vestibular/ear_phenot1.60780102
23MP0002282_abnormal_trachea_morphology1.55815578
24MP0002876_abnormal_thyroid_physiology1.55595500
25MP0005551_abnormal_eye_electrophysiolog1.44281205
26MP0008789_abnormal_olfactory_epithelium1.42114614
27MP0002735_abnormal_chemical_nociception1.41308537
28MP0003136_yellow_coat_color1.37253366
29MP0005083_abnormal_biliary_tract1.34247573
30MP0008872_abnormal_physiological_respon1.31046681
31MP0002249_abnormal_larynx_morphology1.26378694
32MP0002102_abnormal_ear_morphology1.24734165
33MP0009046_muscle_twitch1.22526374
34MP0001968_abnormal_touch/_nociception1.22495919
35MP0005389_reproductive_system_phenotype1.22035267
36MP0000026_abnormal_inner_ear1.21813220
37MP0003718_maternal_effect1.21688971
38MP0005499_abnormal_olfactory_system1.21220812
39MP0005394_taste/olfaction_phenotype1.21220812
40MP0002638_abnormal_pupillary_reflex1.21133739
41MP0001986_abnormal_taste_sensitivity1.21131446
42MP0000383_abnormal_hair_follicle1.18875337
43MP0003646_muscle_fatigue1.18200678
44MP0003011_delayed_dark_adaptation1.13075654
45MP0005647_abnormal_sex_gland1.09674556
46MP0002734_abnormal_mechanical_nocicepti1.08246768
47MP0002928_abnormal_bile_duct1.07725609
48MP0009745_abnormal_behavioral_response1.04562186
49MP0003195_calcinosis1.04303714
50MP0002822_catalepsy1.04183644
51MP0002229_neurodegeneration1.02693270
52MP0005395_other_phenotype1.02581726
53MP0008995_early_reproductive_senescence1.00826304
54MP0000534_abnormal_ureter_morphology1.00816663
55MP0000631_abnormal_neuroendocrine_gland1.00626845
56MP0001963_abnormal_hearing_physiology0.99459136
57MP0004264_abnormal_extraembryonic_tissu0.99263125
58MP0002557_abnormal_social/conspecific_i0.98985708
59MP0001293_anophthalmia0.98746297
60MP0001486_abnormal_startle_reflex0.97102150
61MP0000372_irregular_coat_pigmentation0.95413726
62MP0001529_abnormal_vocalization0.94353423
63MP0001905_abnormal_dopamine_level0.93606211
64MP0009379_abnormal_foot_pigmentation0.92851008
65MP0001970_abnormal_pain_threshold0.92628608
66MP0002909_abnormal_adrenal_gland0.92218425
67MP0005636_abnormal_mineral_homeostasis0.90352468
68MP0004233_abnormal_muscle_weight0.88450906
69MP0002272_abnormal_nervous_system0.88165555
70MP0003115_abnormal_respiratory_system0.87045490
71MP0002736_abnormal_nociception_after0.85050783
72MP0004142_abnormal_muscle_tone0.82760582
73MP0006276_abnormal_autonomic_nervous0.82663194
74MP0002837_dystrophic_cardiac_calcinosis0.80862952
75MP0003656_abnormal_erythrocyte_physiolo0.80762769
76MP0002572_abnormal_emotion/affect_behav0.79666927
77MP0005174_abnormal_tail_pigmentation0.78579219
78MP0001849_ear_inflammation0.77781832
79MP0004019_abnormal_vitamin_homeostasis0.77357473
80MP0008058_abnormal_DNA_repair0.77116507
81MP0006292_abnormal_olfactory_placode0.76058800
82MP0000955_abnormal_spinal_cord0.73249146
83MP0004885_abnormal_endolymph0.72711498
84MP0003880_abnormal_central_pattern0.72538153
85MP0005310_abnormal_salivary_gland0.71493447
86MP0005645_abnormal_hypothalamus_physiol0.69703517
87MP0005365_abnormal_bile_salt0.68801183
88MP0005195_abnormal_posterior_eye0.67747179
89MP0004043_abnormal_pH_regulation0.67131771
90MP0002234_abnormal_pharynx_morphology0.66965661
91MP0001348_abnormal_lacrimal_gland0.66608724
92MP0002138_abnormal_hepatobiliary_system0.66329271
93MP0000467_abnormal_esophagus_morphology0.64996923
94MP0006036_abnormal_mitochondrial_physio0.64749465
95MP0002067_abnormal_sensory_capabilities0.64425248
96MP0005085_abnormal_gallbladder_physiolo0.63043919
97MP0002796_impaired_skin_barrier0.62950364
98MP0000462_abnormal_digestive_system0.62863385
99MP0004085_abnormal_heartbeat0.62741488
100MP0003699_abnormal_female_reproductive0.60397512
101MP0000537_abnormal_urethra_morphology0.60196882
102MP0003252_abnormal_bile_duct0.60136684
103MP0003942_abnormal_urinary_system0.58798215
104MP0002254_reproductive_system_inflammat0.58721401
105MP0001764_abnormal_homeostasis0.55018579
106MP0000569_abnormal_digit_pigmentation0.51352103
107MP0001270_distended_abdomen0.50075146
108MP0002896_abnormal_bone_mineralization0.49934729
109MP0003879_abnormal_hair_cell0.48629616
110MP0009250_abnormal_appendicular_skeleto0.47658169
111MP0002139_abnormal_hepatobiliary_system0.47444102
112MP0003693_abnormal_embryo_hatching0.47419862
113MP0008004_abnormal_stomach_pH0.46011419
114MP0001324_abnormal_eye_pigmentation0.45291530
115MP0001666_abnormal_nutrient_absorption0.44632479
116MP0009115_abnormal_fat_cell0.42617185
117MP0005220_abnormal_exocrine_pancreas0.42598871
118MP0002693_abnormal_pancreas_physiology0.41823441
119MP0001119_abnormal_female_reproductive0.41287200
120MP0003861_abnormal_nervous_system0.40991172
121MP0000427_abnormal_hair_cycle0.39042597
122MP0005391_vision/eye_phenotype0.38431041
123MP0005666_abnormal_adipose_tissue0.38231837
124MP0002092_abnormal_eye_morphology0.38149085
125MP0010234_abnormal_vibrissa_follicle0.38005731
126MP0001485_abnormal_pinna_reflex0.35916625
127MP0006072_abnormal_retinal_apoptosis0.35240459
128MP0004742_abnormal_vestibular_system0.34966468
129MP0000490_abnormal_crypts_of0.34692854
130MP0009643_abnormal_urine_homeostasis0.33392864
131MP0002233_abnormal_nose_morphology0.33010309
132MP0001944_abnormal_pancreas_morphology0.32969926
133MP0003936_abnormal_reproductive_system0.32024204
134MP0005375_adipose_tissue_phenotype0.31955335
135MP0005423_abnormal_somatic_nervous0.31931685
136MP0003787_abnormal_imprinting0.30943418
137MP0005253_abnormal_eye_physiology0.30483367
138MP0000538_abnormal_urinary_bladder0.30083107
139MP0001873_stomach_inflammation0.30017599
140MP0005084_abnormal_gallbladder_morpholo0.29809432
141MP0000613_abnormal_salivary_gland0.29413273
142MP0002132_abnormal_respiratory_system0.28967617
143MP0002152_abnormal_brain_morphology0.28838154
144MP0000049_abnormal_middle_ear0.28571697
145MP0003300_gastrointestinal_ulcer0.28008009
146MP0005360_urolithiasis0.26559104
147MP0008875_abnormal_xenobiotic_pharmacok0.26037088
148MP0005397_hematopoietic_system_phenotyp0.24451238
149MP0001545_abnormal_hematopoietic_system0.24451238
150MP0002168_other_aberrant_phenotype0.24272508
151MP0000003_abnormal_adipose_tissue0.23680026
152MP0003119_abnormal_digestive_system0.23641911
153MP0001502_abnormal_circadian_rhythm0.23407162
154MP0002295_abnormal_pulmonary_circulatio0.23190481
155MP0000432_abnormal_head_morphology0.23042899
156MP0003786_premature_aging0.22720507
157MP0005319_abnormal_enzyme/_coenzyme0.22008128

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.24875352
2Abnormal respiratory motile cilium morphology (HP:0005938)8.92958237
3Abnormal respiratory epithelium morphology (HP:0012253)8.92958237
4Rhinitis (HP:0012384)7.66044479
5Abnormal ciliary motility (HP:0012262)7.39817692
6Chronic bronchitis (HP:0004469)7.15131141
7Infertility (HP:0000789)6.54028111
8Nasal polyposis (HP:0100582)5.98814351
9Abnormality of the nasal mucosa (HP:0000433)5.08975928
10Male infertility (HP:0003251)4.90746004
11Bronchiectasis (HP:0002110)4.63819828
12Bronchitis (HP:0012387)4.56146676
13Nephronophthisis (HP:0000090)4.43816314
14Pancreatic cysts (HP:0001737)3.81628987
15Chronic hepatic failure (HP:0100626)3.62780167
16Abnormality of the renal medulla (HP:0100957)3.58581669
17Tubulointerstitial nephritis (HP:0001970)3.41666672
18Abnormal spermatogenesis (HP:0008669)3.39274447
19Recurrent otitis media (HP:0000403)3.24304132
20Impulsivity (HP:0100710)3.01587965
21Recurrent sinusitis (HP:0011108)2.83949786
22Recurrent bronchitis (HP:0002837)2.83490366
23Molar tooth sign on MRI (HP:0002419)2.80060976
24Abnormality of midbrain morphology (HP:0002418)2.80060976
25Tubulointerstitial abnormality (HP:0001969)2.69454845
26Atelectasis (HP:0100750)2.66496770
27Medial flaring of the eyebrow (HP:0010747)2.51607146
28Tubular atrophy (HP:0000092)2.50033341
29Hyperactive renin-angiotensin system (HP:0000841)2.49534328
30Sclerocornea (HP:0000647)2.46526420
31Anencephaly (HP:0002323)2.45094383
32Hemorrhage of the eye (HP:0011885)2.30087135
33Chronic otitis media (HP:0000389)2.22547906
34Bell-shaped thorax (HP:0001591)2.20109433
35Gonadotropin excess (HP:0000837)2.19483002
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.18485504
37Tubulointerstitial fibrosis (HP:0005576)2.13394319
38Abnormality of renal excretion (HP:0011036)2.13384754
39Male pseudohermaphroditism (HP:0000037)2.13273163
40Abnormal rod and cone electroretinograms (HP:0008323)2.09286640
41Anosmia (HP:0000458)2.07793276
42Dyschromatopsia (HP:0007641)2.05838831
43Abnormality of macular pigmentation (HP:0008002)2.04478689
44Stage 5 chronic kidney disease (HP:0003774)2.02878619
45Abnormality of permanent molar morphology (HP:0011071)2.01274694
46Abnormality of the dental root (HP:0006486)2.01274694
47Taurodontia (HP:0000679)2.01274694
48Heterotopia (HP:0002282)2.01239558
49Azoospermia (HP:0000027)2.01022193
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6792730
51Dynein arm defect of respiratory motile cilia (HP:0012255)12.3992164
52Absent/shortened dynein arms (HP:0200106)12.3992164
53Abnormality of the renal cortex (HP:0011035)1.94985986
54Decreased circulating renin level (HP:0003351)1.94259789
55Aplasia/Hypoplasia of the spleen (HP:0010451)1.93478453
56Decreased central vision (HP:0007663)1.93066482
57Abnormal drinking behavior (HP:0030082)1.92394259
58Polydipsia (HP:0001959)1.92394259
59Congenital hepatic fibrosis (HP:0002612)1.91531226
60Cholecystitis (HP:0001082)1.90467560
61Abnormal gallbladder physiology (HP:0012438)1.90467560
62Postaxial foot polydactyly (HP:0001830)1.88092214
63Abnormality of molar (HP:0011077)1.87484813
64Abnormality of molar morphology (HP:0011070)1.87484813
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87132131
66Asplenia (HP:0001746)1.86635500
67Abnormality of the dental pulp (HP:0006479)1.83312879
68Facial cleft (HP:0002006)1.80735830
69Renal salt wasting (HP:0000127)1.80486283
70Abnormality of dentin (HP:0010299)1.80204223
71Furrowed tongue (HP:0000221)1.78586480
72Cystic liver disease (HP:0006706)1.78325279
73Spastic tetraparesis (HP:0001285)1.76871635
74Abnormal biliary tract physiology (HP:0012439)1.74562277
75Bile duct proliferation (HP:0001408)1.74562277
76Choroideremia (HP:0001139)1.71923280
77Abnormal urine output (HP:0012590)1.70268810
78Short ribs (HP:0000773)1.70262062
79Oculomotor apraxia (HP:0000657)1.66516255
80Severe visual impairment (HP:0001141)1.64472981
81Postaxial hand polydactyly (HP:0001162)1.63936006
82Chronic sinusitis (HP:0011109)1.63084878
83Fibular hypoplasia (HP:0003038)1.62715316
84Type II lissencephaly (HP:0007260)1.60189825
85Bony spicule pigmentary retinopathy (HP:0007737)1.59786102
86Cone-rod dystrophy (HP:0000548)1.58348634
87Hyperaldosteronism (HP:0000859)1.58091884
88Renal dysplasia (HP:0000110)1.57909676
89Median cleft lip (HP:0000161)1.56414642
90Vascular calcification (HP:0004934)1.52783021
91Pancreatic fibrosis (HP:0100732)1.52479677
92Broad distal phalanx of finger (HP:0009836)1.52399091
93Congenital primary aphakia (HP:0007707)1.51481593
94Abnormality of chloride homeostasis (HP:0011422)1.50801859
95Aplasia/Hypoplasia of the lens (HP:0008063)1.50051410
96Retinal dysplasia (HP:0007973)1.50050126
97Constricted visual fields (HP:0001133)1.49673882
98Short thorax (HP:0010306)1.49544044
99Supernumerary spleens (HP:0009799)1.49107123
100Preaxial hand polydactyly (HP:0001177)1.48223347
101Gait imbalance (HP:0002141)1.48032796
102Short nail (HP:0001799)1.47742369
103Hypokalemic alkalosis (HP:0001949)1.45488965
104Abnormality of renin-angiotensin system (HP:0000847)1.45078138
105Polyuria (HP:0000103)1.44669444
106Attenuation of retinal blood vessels (HP:0007843)1.44540329
107Poor coordination (HP:0002370)1.41928793
108True hermaphroditism (HP:0010459)1.39774884
109Nephropathy (HP:0000112)1.37572216
110Cardiovascular calcification (HP:0011915)1.35575035
111Hyponatremia (HP:0002902)1.33683010
112Nephrogenic diabetes insipidus (HP:0009806)1.31792161
113Buphthalmos (HP:0000557)1.31208018
114Genital tract atresia (HP:0001827)1.30819140
115Bundle branch block (HP:0011710)1.30700431
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.30580508
117Glucose intolerance (HP:0000833)1.30462374
118Truncal obesity (HP:0001956)1.29503090
119Hypoplasia of dental enamel (HP:0006297)1.29420892
120Vaginal atresia (HP:0000148)1.28998045
121Recurrent corneal erosions (HP:0000495)1.28802920
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.26172815
123Potter facies (HP:0002009)1.25985549
124Facial shape deformation (HP:0011334)1.25985549
125Short femoral neck (HP:0100864)1.24126281
126Congenital stationary night blindness (HP:0007642)1.22981772
127Narrow forehead (HP:0000341)1.22312758
128Hyperkalemia (HP:0002153)1.21246381
129Occipital encephalocele (HP:0002085)1.19386896
130Hypoplastic labia majora (HP:0000059)1.18263986
131Easy fatigability (HP:0003388)1.17307067
132Hyperphosphatemia (HP:0002905)1.17003102
133Multicystic kidney dysplasia (HP:0000003)1.15263300
134Holoprosencephaly (HP:0001360)1.14783021
135Aganglionic megacolon (HP:0002251)1.13939347
136Abnormality of the pons (HP:0007361)1.10982350
137Prominent nasal bridge (HP:0000426)1.10458133
138Retinitis pigmentosa (HP:0000510)1.08883131
139Abnormality of potassium homeostasis (HP:0011042)1.08874805
140Hypoplasia of the pons (HP:0012110)1.08260448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.22703251
2PDK47.22703251
3TESK16.45380179
4PRKD35.77016975
5PDK24.73856916
6ICK4.44314983
7MAP4K22.83238910
8WNK42.71086178
9STK392.61816677
10PNCK2.35594057
11TLK12.00744076
12STK381.96406191
13NME11.94960891
14PTK2B1.89498479
15MAPK151.89425838
16DYRK1B1.83311252
17ADRBK21.76023481
18BCKDK1.54637939
19MAP3K41.52593051
20NEK21.38692998
21MAP2K71.25810017
22DYRK31.19491918
23FRK1.18392982
24STK38L1.11902166
25PLK21.11195818
26EEF2K1.08065351
27BCR1.03989420
28ERBB20.96552479
29MAP2K20.93897026
30CAMK1D0.91145263
31MAPK130.87845646
32PDK10.86381889
33PASK0.82493990
34WNK10.81990690
35LMTK20.81866709
36DYRK20.81411788
37TSSK60.80119037
38ERBB30.78069325
39CAMKK20.77477851
40IRAK10.73332197
41ADRBK10.72844777
42STK240.72679195
43CAMK1G0.71555044
44STK30.68789322
45EPHA20.66197747
46MAPKAPK50.63100960
47PRKAA20.60401416
48MAP3K70.60009284
49MAPKAPK30.59089223
50TRPM70.56638823
51PLK40.56382159
52PDPK10.55800258
53PRKACA0.55170233
54MAP2K60.54386249
55PRKCE0.54228384
56TIE10.54063016
57CHEK20.52796032
58DDR20.52331649
59TTK0.50341164
60ZAK0.49369265
61TYRO30.49247502
62CASK0.48320543
63ABL20.46446892
64MTOR0.46249632
65GRK60.45618743
66TNK20.45027342
67LATS10.44829088
68ROCK10.44415965
69CAMK10.43186787
70SGK10.42950839
71PRKCA0.42564551
72LRRK20.42289132
73TRIM280.41933367
74PRKCD0.41898174
75PAK10.41777191
76MAP2K40.41573266
77WNK30.40852747
78CSK0.38869453
79IRAK20.38529830
80AKT30.36889619
81CAMKK10.35972266
82GRK10.35008804
83IKBKB0.33943325
84CDK120.33662429
85BRSK20.33226369
86TEC0.32679193
87CHEK10.32426409
88CAMK2A0.31747148
89CDK80.31413424
90TESK20.31340111
91CDK30.30907919
92EPHA30.30302977
93GRK70.29779532
94NTRK30.29717232
95PRKCG0.29677138
96ITK0.28467547
97PAK30.27030066
98PRKCQ0.26713507
99MUSK0.26694561
100PRKCH0.26407686
101PAK20.25937301
102INSRR0.25723651
103PINK10.25550987
104PKN10.25517020
105CSNK1A10.25252373
106CHUK0.25189738
107IGF1R0.24835968
108CAMK2G0.24626035
109FER0.24487416
110PRKAA10.23964236
111DYRK1A0.23273186
112RPS6KA50.22749630
113TGFBR20.22434840
114RPS6KB10.22185689
115OXSR10.21869676
116NEK60.21836977
117ARAF0.21424101
118PRKCZ0.20727628
119RPS6KA10.20654224
120MST1R0.20272329
121MARK20.19896202
122AURKA0.19404866
123PHKG20.18634057
124PHKG10.18634057
125ATM0.17438729
126CDC70.16223046
127NTRK20.13805379
128BMPR20.13712376
129MAP3K100.13086390
130FGFR20.12787034
131RIPK40.12141361
132PIK3CG0.12044301
133RPS6KA20.12007438
134BMPR1B0.10735325
135PAK40.10558270
136BRAF0.09545575
137PRKCI0.09097290
138MAP3K20.08835120
139PIM20.08011122
140GSK3B0.07365344
141ATR0.07222988
142CDK60.06157975
143MAP3K10.05630667
144CCNB10.05391122
145MET0.05377741
146SIK10.05323985
147CSNK2A20.05075116
148CSNK2A10.04285049
149MST40.04173932
150TAOK10.04085957
151ERN10.03470730
152DAPK20.03454391
153PLK10.03146971
154STK100.03097316
155CSNK1E0.01869535
156STK160.01381955
157TAOK30.01359621
158PRKG10.01245498

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.88544445
2Fatty acid biosynthesis_Homo sapiens_hsa000613.69427769
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.42449497
4Phenylalanine metabolism_Homo sapiens_hsa003603.36549992
5Pyruvate metabolism_Homo sapiens_hsa006203.09870437
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09436059
7Tyrosine metabolism_Homo sapiens_hsa003503.01438026
8Vitamin B6 metabolism_Homo sapiens_hsa007502.94440923
9Histidine metabolism_Homo sapiens_hsa003402.93386321
10Linoleic acid metabolism_Homo sapiens_hsa005912.91442052
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.78933496
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.72298448
13Propanoate metabolism_Homo sapiens_hsa006402.63618791
14beta-Alanine metabolism_Homo sapiens_hsa004102.59589645
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55889792
16Glucagon signaling pathway_Homo sapiens_hsa049222.32987279
17Glycerolipid metabolism_Homo sapiens_hsa005612.30408657
18Caffeine metabolism_Homo sapiens_hsa002322.24058632
19Oxidative phosphorylation_Homo sapiens_hsa001902.22335961
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21938848
21Selenocompound metabolism_Homo sapiens_hsa004502.14119620
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11366090
23Basal transcription factors_Homo sapiens_hsa030222.00291865
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99151286
25Retinol metabolism_Homo sapiens_hsa008301.92443563
26Mineral absorption_Homo sapiens_hsa049781.91901550
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.81652339
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.80057321
29Dorso-ventral axis formation_Homo sapiens_hsa043201.79326512
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76405850
31Phototransduction_Homo sapiens_hsa047441.72012724
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.71753674
33Butanoate metabolism_Homo sapiens_hsa006501.71069613
34PPAR signaling pathway_Homo sapiens_hsa033201.66169006
35Fructose and mannose metabolism_Homo sapiens_hsa000511.62110575
36Fat digestion and absorption_Homo sapiens_hsa049751.62024943
37Parkinsons disease_Homo sapiens_hsa050121.53325829
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50369512
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48371407
40Arachidonic acid metabolism_Homo sapiens_hsa005901.44033334
41Fatty acid degradation_Homo sapiens_hsa000711.41929188
42mRNA surveillance pathway_Homo sapiens_hsa030151.37989175
43Nitrogen metabolism_Homo sapiens_hsa009101.36288893
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.36092618
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34074722
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32837086
47Amphetamine addiction_Homo sapiens_hsa050311.27303591
48Protein digestion and absorption_Homo sapiens_hsa049741.27009750
49Oocyte meiosis_Homo sapiens_hsa041141.26206126
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25184705
51Sulfur metabolism_Homo sapiens_hsa009201.24850048
52Ether lipid metabolism_Homo sapiens_hsa005651.23170112
53Insulin secretion_Homo sapiens_hsa049111.20482840
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.18657785
55Nicotine addiction_Homo sapiens_hsa050331.17443796
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11644468
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.08973011
58Alzheimers disease_Homo sapiens_hsa050101.07756269
59Fatty acid metabolism_Homo sapiens_hsa012121.05442581
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05317147
61Taste transduction_Homo sapiens_hsa047421.05292902
62Renin-angiotensin system_Homo sapiens_hsa046141.04359212
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04005098
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02490457
65Glutathione metabolism_Homo sapiens_hsa004801.02264387
66Purine metabolism_Homo sapiens_hsa002300.98407948
67Pentose phosphate pathway_Homo sapiens_hsa000300.98226341
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97687677
69Pancreatic secretion_Homo sapiens_hsa049720.97112398
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.94404701
71Huntingtons disease_Homo sapiens_hsa050160.94314317
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94133523
73RNA polymerase_Homo sapiens_hsa030200.94043471
74Hedgehog signaling pathway_Homo sapiens_hsa043400.92003175
75Allograft rejection_Homo sapiens_hsa053300.90993296
76Thyroid hormone synthesis_Homo sapiens_hsa049180.90933708
77Fanconi anemia pathway_Homo sapiens_hsa034600.90347077
78RNA transport_Homo sapiens_hsa030130.89288056
79Autoimmune thyroid disease_Homo sapiens_hsa053200.87814151
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87234104
81Chemical carcinogenesis_Homo sapiens_hsa052040.84951194
82Type I diabetes mellitus_Homo sapiens_hsa049400.84846741
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.84701320
84Arginine and proline metabolism_Homo sapiens_hsa003300.84595327
85Bile secretion_Homo sapiens_hsa049760.84461359
86Carbon metabolism_Homo sapiens_hsa012000.84059412
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84009799
88Tryptophan metabolism_Homo sapiens_hsa003800.83755697
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.82460460
90Antigen processing and presentation_Homo sapiens_hsa046120.77330857
91ABC transporters_Homo sapiens_hsa020100.75179272
92Olfactory transduction_Homo sapiens_hsa047400.75058644
93Inositol phosphate metabolism_Homo sapiens_hsa005620.73260067
94Protein export_Homo sapiens_hsa030600.67448225
95Estrogen signaling pathway_Homo sapiens_hsa049150.66951802
96Renin secretion_Homo sapiens_hsa049240.66895516
97Asthma_Homo sapiens_hsa053100.66819465
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65296803
99Collecting duct acid secretion_Homo sapiens_hsa049660.64828951
100Vitamin digestion and absorption_Homo sapiens_hsa049770.64179443
101Graft-versus-host disease_Homo sapiens_hsa053320.61345528
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.60766762
103Ribosome_Homo sapiens_hsa030100.60115923
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59920244
105Gastric acid secretion_Homo sapiens_hsa049710.55316699
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54552550
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53832963
108Cardiac muscle contraction_Homo sapiens_hsa042600.51417356
109AMPK signaling pathway_Homo sapiens_hsa041520.48536148
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.48450684
111Systemic lupus erythematosus_Homo sapiens_hsa053220.48299953
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47003849
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46572450
114Tight junction_Homo sapiens_hsa045300.45888947
115Serotonergic synapse_Homo sapiens_hsa047260.45266688
116Alcoholism_Homo sapiens_hsa050340.44977491
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44442030
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44135717
119Metabolic pathways_Homo sapiens_hsa011000.40354324
120Circadian rhythm_Homo sapiens_hsa047100.38128030
121N-Glycan biosynthesis_Homo sapiens_hsa005100.36716205
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36698086
123Endocytosis_Homo sapiens_hsa041440.36503787
124Insulin resistance_Homo sapiens_hsa049310.35551571
125Legionellosis_Homo sapiens_hsa051340.34613577
126Salivary secretion_Homo sapiens_hsa049700.34217700
127Basal cell carcinoma_Homo sapiens_hsa052170.32001242
128Sulfur relay system_Homo sapiens_hsa041220.31327980
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31048104
130Morphine addiction_Homo sapiens_hsa050320.30860896
131Regulation of autophagy_Homo sapiens_hsa041400.29976139
132Homologous recombination_Homo sapiens_hsa034400.29401009
133Synaptic vesicle cycle_Homo sapiens_hsa047210.29169371
134Cocaine addiction_Homo sapiens_hsa050300.28911072
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.27337054
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.26410569
137Starch and sucrose metabolism_Homo sapiens_hsa005000.26371485
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26020574
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24161715
140Long-term potentiation_Homo sapiens_hsa047200.24023982
141Calcium signaling pathway_Homo sapiens_hsa040200.24016892
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.21957963
143Sphingolipid metabolism_Homo sapiens_hsa006000.21822986
144Vibrio cholerae infection_Homo sapiens_hsa051100.21687555
145Biosynthesis of amino acids_Homo sapiens_hsa012300.20623165
146Other glycan degradation_Homo sapiens_hsa005110.18783109
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18642618
148cAMP signaling pathway_Homo sapiens_hsa040240.17872744
149Insulin signaling pathway_Homo sapiens_hsa049100.16017593
150Pyrimidine metabolism_Homo sapiens_hsa002400.15844185
151Peroxisome_Homo sapiens_hsa041460.15713283
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15524664

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