TTC9C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.44466675
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.37135499
3regulation of retinoic acid receptor signaling pathway (GO:0048385)4.81335072
4protein deneddylation (GO:0000338)4.56792643
5rRNA modification (GO:0000154)4.25701414
6proteasome assembly (GO:0043248)4.17421963
7protein localization to kinetochore (GO:0034501)4.12194649
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11960015
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.08968270
10NADH dehydrogenase complex assembly (GO:0010257)4.08968270
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08968270
12cullin deneddylation (GO:0010388)4.07749917
13protein complex biogenesis (GO:0070271)4.01921146
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94749100
15ATP synthesis coupled proton transport (GO:0015986)3.94749100
16mitochondrial respiratory chain complex assembly (GO:0033108)3.91489556
17kinetochore organization (GO:0051383)3.88868907
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87799670
19mitotic metaphase plate congression (GO:0007080)3.86557871
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.85577506
21maturation of SSU-rRNA (GO:0030490)3.79434473
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.78167907
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76829086
24meiotic chromosome segregation (GO:0045132)3.75437224
25metaphase plate congression (GO:0051310)3.73393681
26respiratory chain complex IV assembly (GO:0008535)3.67556635
27rRNA methylation (GO:0031167)3.65216152
28mitotic sister chromatid segregation (GO:0000070)3.63672366
29transcription from mitochondrial promoter (GO:0006390)3.61832994
30establishment of chromosome localization (GO:0051303)3.58910175
31protein-cofactor linkage (GO:0018065)3.55193660
32DNA deamination (GO:0045006)3.54712102
33CENP-A containing nucleosome assembly (GO:0034080)3.50273816
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.50201923
35sister chromatid segregation (GO:0000819)3.46844599
36protein localization to chromosome, centromeric region (GO:0071459)3.46130244
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42259471
38kinetochore assembly (GO:0051382)3.37641745
39platelet dense granule organization (GO:0060155)3.37598853
40chromatin remodeling at centromere (GO:0031055)3.37510682
41attachment of spindle microtubules to kinetochore (GO:0008608)3.35961941
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34587509
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34478191
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32288805
45synapsis (GO:0007129)3.31281507
46DNA strand elongation involved in DNA replication (GO:0006271)3.28917108
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.26888325
48termination of RNA polymerase III transcription (GO:0006386)3.26888325
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25231987
50DNA unwinding involved in DNA replication (GO:0006268)3.24254893
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24031369
52respiratory electron transport chain (GO:0022904)3.22627476
53electron transport chain (GO:0022900)3.20665843
54mitotic recombination (GO:0006312)3.19799042
55telomere maintenance via semi-conservative replication (GO:0032201)3.19391586
56maturation of 5.8S rRNA (GO:0000460)3.18326536
57mitotic chromosome condensation (GO:0007076)3.18273592
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16938015
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16938015
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16938015
61piRNA metabolic process (GO:0034587)3.15806273
62DNA strand elongation (GO:0022616)3.15062873
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12602527
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12602527
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12390017
66negative regulation of ligase activity (GO:0051352)3.12390017
67telomere maintenance via recombination (GO:0000722)3.09927906
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.09917928
69regulation of helicase activity (GO:0051095)3.09800141
70DNA replication-independent nucleosome organization (GO:0034724)3.09300815
71DNA replication-independent nucleosome assembly (GO:0006336)3.09300815
72regulation of meiosis I (GO:0060631)3.07310271
73DNA replication initiation (GO:0006270)3.06220912
74mitotic nuclear envelope disassembly (GO:0007077)3.05932214
75protein targeting to mitochondrion (GO:0006626)3.05821519
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.04148769
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04148769
78protein localization to chromosome (GO:0034502)3.01808721
79nuclear pore organization (GO:0006999)3.00349545
80spindle checkpoint (GO:0031577)3.00064443
81DNA damage response, detection of DNA damage (GO:0042769)2.99421112
82regulation of cellular amino acid metabolic process (GO:0006521)2.98618688
83regulation of spindle organization (GO:0090224)2.98102519
84organelle disassembly (GO:1903008)2.97902093
85ribosomal small subunit assembly (GO:0000028)2.96478248
86pseudouridine synthesis (GO:0001522)2.96276780
87cytochrome complex assembly (GO:0017004)2.95781624
88meiosis I (GO:0007127)2.94458503
89mitotic sister chromatid cohesion (GO:0007064)2.94175971
90nuclear pore complex assembly (GO:0051292)2.93420224
91male meiosis I (GO:0007141)2.93352290
92DNA double-strand break processing (GO:0000729)2.93112834
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92757967
94DNA replication-dependent nucleosome assembly (GO:0006335)2.92467452
95DNA replication-dependent nucleosome organization (GO:0034723)2.92467452
96protein localization to mitochondrion (GO:0070585)2.90057547
97cotranslational protein targeting to membrane (GO:0006613)2.89912405
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89725496
99establishment of protein localization to mitochondrion (GO:0072655)2.88842529
100transcription elongation from RNA polymerase I promoter (GO:0006362)2.88233768
101cellular component biogenesis (GO:0044085)2.88127124
102chromosome segregation (GO:0007059)2.86430514
103regulation of mitotic spindle organization (GO:0060236)2.85484413
104positive regulation of ligase activity (GO:0051351)2.85103009
105mitochondrial RNA metabolic process (GO:0000959)2.84529035
106translation (GO:0006412)2.84451505
107translational termination (GO:0006415)2.84173432
108establishment of integrated proviral latency (GO:0075713)2.83748139
109water-soluble vitamin biosynthetic process (GO:0042364)2.83162004
110termination of RNA polymerase I transcription (GO:0006363)2.82421776
111protein targeting to ER (GO:0045047)2.80590698
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79857412
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79857412
114telomere maintenance via telomere lengthening (GO:0010833)2.79217918
115viral transcription (GO:0019083)2.78999203
116spindle assembly checkpoint (GO:0071173)2.77771625
117DNA ligation (GO:0006266)2.75668204
118positive regulation of mitochondrial fission (GO:0090141)2.75404576
119base-excision repair, AP site formation (GO:0006285)2.74580330
120nuclear envelope disassembly (GO:0051081)2.74248463
121membrane disassembly (GO:0030397)2.74248463
122regulation of DNA endoreduplication (GO:0032875)2.73603826
123mitotic spindle checkpoint (GO:0071174)2.72703649
124negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72346308
125tRNA processing (GO:0008033)2.72178219
126DNA replication checkpoint (GO:0000076)2.71407883
127nucleotide-excision repair, DNA gap filling (GO:0006297)2.71052331
128deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70812236
129ribonucleoprotein complex disassembly (GO:0032988)2.70689947
130histone H2A acetylation (GO:0043968)2.70579599
131GDP-mannose metabolic process (GO:0019673)2.69888308
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.69427279
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69427279
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69427279
135negative regulation of sister chromatid segregation (GO:0033046)2.69427279
136histone exchange (GO:0043486)2.67823647
137mitotic spindle assembly checkpoint (GO:0007094)2.67647824
138establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67425348
139protein localization to endoplasmic reticulum (GO:0070972)2.67172956
140rRNA processing (GO:0006364)2.67011760
141nucleoside transmembrane transport (GO:1901642)2.66152255
142mismatch repair (GO:0006298)2.65992919
143negative regulation of DNA-dependent DNA replication (GO:2000104)2.65425490
144negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64129920
145negative regulation of chromosome segregation (GO:0051985)2.62767161
146regulation of chromosome segregation (GO:0051983)2.62128029
147regulation of centrosome cycle (GO:0046605)2.61652532
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59094744
149regulation of mitotic spindle checkpoint (GO:1903504)2.59094744
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58459226
151microtubule depolymerization (GO:0007019)2.55887662
152transcription-coupled nucleotide-excision repair (GO:0006283)2.55074136
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54615087
154histone mRNA metabolic process (GO:0008334)2.53781186
155protein K6-linked ubiquitination (GO:0085020)2.53532197
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.53202862
157regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51136955
158DNA topological change (GO:0006265)2.50774987
159regulation of centriole replication (GO:0046599)2.50737859
160telomere maintenance (GO:0000723)2.50098369
161regulation of mitotic sister chromatid separation (GO:0010965)2.49476471
162regulation of mitotic sister chromatid segregation (GO:0033047)2.49476471
163regulation of sister chromatid segregation (GO:0033045)2.49476471
164positive regulation of histone H3-K4 methylation (GO:0051571)2.49142095
165alternative mRNA splicing, via spliceosome (GO:0000380)2.48088564
166telomere organization (GO:0032200)2.47118672
167RNA-dependent DNA replication (GO:0006278)2.44752960
1687-methylguanosine RNA capping (GO:0009452)2.44280068
169RNA capping (GO:0036260)2.44280068
170regulation of double-strand break repair via homologous recombination (GO:0010569)2.44130931
171ribosomal large subunit biogenesis (GO:0042273)2.42065147
1727-methylguanosine mRNA capping (GO:0006370)2.41304825
173ATP-dependent chromatin remodeling (GO:0043044)2.40650665
174chromatin assembly or disassembly (GO:0006333)2.39915128
175somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.37330912
176somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.37330912
177isotype switching (GO:0045190)2.37330912
178pore complex assembly (GO:0046931)2.37272618
179DNA catabolic process, exonucleolytic (GO:0000738)2.36410479
180positive regulation of chromosome segregation (GO:0051984)2.36369036
181regulation of telomere maintenance via telomerase (GO:0032210)2.35701022
182mitotic cell cycle (GO:0000278)2.34015764
183RNA splicing, via transesterification reactions (GO:0000375)2.33056704
184positive regulation of DNA-dependent DNA replication (GO:2000105)2.31580742
185establishment of viral latency (GO:0019043)2.31498276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.76870891
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.01203549
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06807254
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64911879
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.04914175
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99688038
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75757606
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.69244982
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.68638704
10* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63105373
11ZNF274_21170338_ChIP-Seq_K562_Hela2.55578601
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.52223928
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45795032
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.45668453
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45129572
16AR_21909140_ChIP-Seq_LNCAP_Human2.29416658
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29346768
18* ELK1_19687146_ChIP-ChIP_HELA_Human2.25018936
19VDR_23849224_ChIP-Seq_CD4+_Human2.23357842
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14937197
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.12690908
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09023729
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07005947
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.06312463
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06220330
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05209449
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04851850
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04797169
29FOXP3_21729870_ChIP-Seq_TREG_Human2.02612180
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01412383
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01271143
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00113151
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.98454619
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98093497
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97676791
36* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93003524
37* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90041198
38* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86139583
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85080001
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85037340
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82367689
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.82262016
43XRN2_22483619_ChIP-Seq_HELA_Human1.75835160
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74156077
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73283218
46TTF2_22483619_ChIP-Seq_HELA_Human1.66337206
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65945496
48DCP1A_22483619_ChIP-Seq_HELA_Human1.63545181
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59260997
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53446105
51* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52469463
52CIITA_25753668_ChIP-Seq_RAJI_Human1.51467747
53MYC_18940864_ChIP-ChIP_HL60_Human1.50793352
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50078637
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46871816
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46239264
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44310296
58* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39443515
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39010075
60GABP_19822575_ChIP-Seq_HepG2_Human1.35990087
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34282542
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.31285325
63TP53_22573176_ChIP-Seq_HFKS_Human1.31231247
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30241667
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28938274
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.28077756
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25032709
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.22840291
69FUS_26573619_Chip-Seq_HEK293_Human1.21023568
70VDR_22108803_ChIP-Seq_LS180_Human1.20965771
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20200725
72* SPI1_23547873_ChIP-Seq_NB4_Human1.16987753
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14812349
74KDM5A_27292631_Chip-Seq_BREAST_Human1.12963951
75IRF1_19129219_ChIP-ChIP_H3396_Human1.12317297
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11679741
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10710395
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09721416
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08789698
80TAF15_26573619_Chip-Seq_HEK293_Human1.08044456
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06820921
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06378422
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05702512
84* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05684928
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04737999
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04417228
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04138814
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03766379
89* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03319307
90EWS_26573619_Chip-Seq_HEK293_Human1.02295961
91MYB_26560356_Chip-Seq_TH2_Human1.01409159
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99596735
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99527309
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98561803
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97113719
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97049457
97IGF1R_20145208_ChIP-Seq_DFB_Human0.96801691
98MYC_22102868_ChIP-Seq_BL_Human0.96795864
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96685629
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96305954
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95360642
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94546172
103YY1_21170310_ChIP-Seq_MESCs_Mouse0.93817370
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93317421
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92466318
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.92397577
107P300_19829295_ChIP-Seq_ESCs_Human0.90394357
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.89017476
109TFEB_21752829_ChIP-Seq_HELA_Human0.88606794
110* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88264191
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88224390
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88153923
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86628057
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86497184
115AR_20517297_ChIP-Seq_VCAP_Human0.86026490
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85696512
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.85205107
118* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84562961
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84441252
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84337423
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83953338
122* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83236839
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.82821329
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80964291
125ELF5_23300383_ChIP-Seq_T47D_Human0.80352468
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79133108
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77599307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.44858903
2MP0010094_abnormal_chromosome_stability3.42883105
3MP0006072_abnormal_retinal_apoptosis3.20454816
4MP0003077_abnormal_cell_cycle2.88204919
5MP0003111_abnormal_nucleus_morphology2.87031168
6MP0008057_abnormal_DNA_replication2.86311319
7MP0001529_abnormal_vocalization2.76739886
8MP0004957_abnormal_blastocyst_morpholog2.58164638
9MP0008058_abnormal_DNA_repair2.52607922
10MP0008007_abnormal_cellular_replicative2.50132364
11MP0006292_abnormal_olfactory_placode2.45585044
12MP0004147_increased_porphyrin_level2.40663683
13MP0003136_yellow_coat_color2.36362823
14MP0003941_abnormal_skin_development2.11612914
15MP0003186_abnormal_redox_activity2.07152906
16MP0008932_abnormal_embryonic_tissue2.04472575
17MP0001835_abnormal_antigen_presentation2.03050309
18MP0006035_abnormal_mitochondrial_morpho2.02492476
19MP0002102_abnormal_ear_morphology1.91627447
20MP0002396_abnormal_hematopoietic_system1.89781775
21MP0003880_abnormal_central_pattern1.86578962
22MP0006036_abnormal_mitochondrial_physio1.85586925
23MP0001986_abnormal_taste_sensitivity1.83939108
24MP0005253_abnormal_eye_physiology1.81392319
25MP0005075_abnormal_melanosome_morpholog1.79663713
26MP0002938_white_spotting1.77477147
27MP0008789_abnormal_olfactory_epithelium1.71380071
28MP0002210_abnormal_sex_determination1.70379197
29MP0009053_abnormal_anal_canal1.69884315
30MP0003806_abnormal_nucleotide_metabolis1.67470150
31MP0001929_abnormal_gametogenesis1.65003543
32MP0005671_abnormal_response_to1.64097953
33MP0004808_abnormal_hematopoietic_stem1.61578528
34MP0003011_delayed_dark_adaptation1.57926057
35MP0002751_abnormal_autonomic_nervous1.56433512
36MP0000350_abnormal_cell_proliferation1.54551617
37MP0002132_abnormal_respiratory_system1.54359265
38MP0005171_absent_coat_pigmentation1.53040399
39MP0003763_abnormal_thymus_physiology1.50332946
40MP0003121_genomic_imprinting1.50238346
41MP0008877_abnormal_DNA_methylation1.49711315
42MP0003123_paternal_imprinting1.49567363
43MP0005551_abnormal_eye_electrophysiolog1.48614375
44MP0000566_synostosis1.46533921
45MP0010352_gastrointestinal_tract_polyps1.44175926
46MP0009785_altered_susceptibility_to1.43929954
47MP0004133_heterotaxia1.42184936
48MP0005389_reproductive_system_phenotype1.35678364
49MP0002160_abnormal_reproductive_system1.35373155
50MP0002398_abnormal_bone_marrow1.32795617
51MP0001800_abnormal_humoral_immune1.32168370
52MP0002653_abnormal_ependyma_morphology1.31958697
53MP0000653_abnormal_sex_gland1.31276201
54MP0002736_abnormal_nociception_after1.30663675
55MP0006276_abnormal_autonomic_nervous1.30278651
56MP0010307_abnormal_tumor_latency1.30134675
57MP0001145_abnormal_male_reproductive1.29268304
58MP0000358_abnormal_cell_content/1.28340273
59MP0002452_abnormal_antigen_presenting1.27646523
60MP0004142_abnormal_muscle_tone1.27582016
61MP0002006_tumorigenesis1.27500035
62MP0001293_anophthalmia1.27167701
63MP0002277_abnormal_respiratory_mucosa1.26197734
64MP0003195_calcinosis1.25600230
65MP0002638_abnormal_pupillary_reflex1.25445196
66MP0005084_abnormal_gallbladder_morpholo1.25329249
67MP0000685_abnormal_immune_system1.23285071
68MP0000631_abnormal_neuroendocrine_gland1.22564483
69MP0001485_abnormal_pinna_reflex1.21982431
70MP0000490_abnormal_crypts_of1.20928657
71MP0000703_abnormal_thymus_morphology1.20178588
72MP0008260_abnormal_autophagy1.20076221
73MP0001764_abnormal_homeostasis1.19569646
74MP0005000_abnormal_immune_tolerance1.19391697
75MP0003937_abnormal_limbs/digits/tail_de1.19348082
76MP0002420_abnormal_adaptive_immunity1.17616791
77MP0005387_immune_system_phenotype1.16669410
78MP0001790_abnormal_immune_system1.16669410
79MP0001819_abnormal_immune_cell1.16476347
80MP0003890_abnormal_embryonic-extraembry1.15557824
81MP0000015_abnormal_ear_pigmentation1.15242352
82MP0002148_abnormal_hypersensitivity_rea1.14842870
83MP0002163_abnormal_gland_morphology1.14633516
84MP0002095_abnormal_skin_pigmentation1.14423712
85MP0002723_abnormal_immune_serum1.12240857
86MP0005391_vision/eye_phenotype1.09995607
87MP0002090_abnormal_vision1.08838436
88MP0002233_abnormal_nose_morphology1.07988973
89MP0005408_hypopigmentation1.07053838
90MP0000569_abnormal_digit_pigmentation1.06567871
91MP0002019_abnormal_tumor_incidence1.06369208
92MP0005174_abnormal_tail_pigmentation1.06277519
93MP0000858_altered_metastatic_potential1.06096333
94MP0003698_abnormal_male_reproductive1.05772384
95MP0000716_abnormal_immune_system1.05154711
96MP0002177_abnormal_outer_ear1.04642627
97MP0001188_hyperpigmentation1.04395267
98MP0000678_abnormal_parathyroid_gland1.04374317
99MP0001346_abnormal_lacrimal_gland1.03987478
100MP0000647_abnormal_sebaceous_gland1.03803389
101MP0002009_preneoplasia1.03398569
102MP0001730_embryonic_growth_arrest1.02835995
103MP0002249_abnormal_larynx_morphology1.02508211
104MP0001324_abnormal_eye_pigmentation1.02388013
105MP0002722_abnormal_immune_system1.02337099
106MP0005394_taste/olfaction_phenotype1.02281335
107MP0005499_abnormal_olfactory_system1.02281335
108MP0001853_heart_inflammation1.01497952
109MP0003718_maternal_effect1.01440017
110MP0000313_abnormal_cell_death1.00275874
111MP0003787_abnormal_imprinting1.00188657
112MP0002085_abnormal_embryonic_tissue0.99045587
113MP0002098_abnormal_vibrissa_morphology0.98989136
114MP0000372_irregular_coat_pigmentation0.98857622
115MP0001697_abnormal_embryo_size0.97710293
116MP0003878_abnormal_ear_physiology0.97298757
117MP0005377_hearing/vestibular/ear_phenot0.97298757
118MP0001919_abnormal_reproductive_system0.96849989
119MP0009697_abnormal_copulation0.96825354
120MP0000689_abnormal_spleen_morphology0.95597991
121MP0002429_abnormal_blood_cell0.95576053
122MP0000427_abnormal_hair_cycle0.94820231
123MP0002111_abnormal_tail_morphology0.94471990
124MP0009379_abnormal_foot_pigmentation0.94229019
125MP0001119_abnormal_female_reproductive0.94120456
126MP0005367_renal/urinary_system_phenotyp0.93801264
127MP0000516_abnormal_urinary_system0.93801264
128MP0010030_abnormal_orbit_morphology0.93590282
129MP0005025_abnormal_response_to0.91848766
130MP0002234_abnormal_pharynx_morphology0.91597071
131MP0003938_abnormal_ear_development0.91443982
132MP0002405_respiratory_system_inflammati0.90053301
133MP0002166_altered_tumor_susceptibility0.89328710
134MP0009250_abnormal_appendicular_skeleto0.89018277
135MP0009333_abnormal_splenocyte_physiolog0.88863042
136MP0001286_abnormal_eye_development0.88704821
137MP0003786_premature_aging0.87486602
138MP0005395_other_phenotype0.87429275
139MP0000465_gastrointestinal_hemorrhage0.87256681
140MP0005397_hematopoietic_system_phenotyp0.86149912
141MP0001545_abnormal_hematopoietic_system0.86149912
142MP0005410_abnormal_fertilization0.86080339
143MP0005195_abnormal_posterior_eye0.86039447
144MP0002419_abnormal_innate_immunity0.85047308
145MP0002877_abnormal_melanocyte_morpholog0.84986280
146MP0000049_abnormal_middle_ear0.84890117
147MP0001968_abnormal_touch/_nociception0.84456865
148MP0003436_decreased_susceptibility_to0.82314015
149MP0005380_embryogenesis_phenotype0.81225098
150MP0001672_abnormal_embryogenesis/_devel0.81225098
151MP0003567_abnormal_fetal_cardiomyocyte0.80179497
152MP0003950_abnormal_plasma_membrane0.76577725
153MP0009046_muscle_twitch0.76050553
154MP0002161_abnormal_fertility/fecundity0.75794377
155MP0003646_muscle_fatigue0.74384265
156MP0003122_maternal_imprinting0.74325050
157MP0004885_abnormal_endolymph0.73762996
158MP0002837_dystrophic_cardiac_calcinosis0.73578765
159MP0008872_abnormal_physiological_respon0.72278724
160MP0000778_abnormal_nervous_system0.71447212
161MP0000371_diluted_coat_color0.71185076
162MP0002282_abnormal_trachea_morphology0.69846713
163MP0001905_abnormal_dopamine_level0.69290798
164MP0005379_endocrine/exocrine_gland_phen0.69090256

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.68425015
2Mitochondrial inheritance (HP:0001427)4.50045082
3Abnormal mitochondria in muscle tissue (HP:0008316)4.45424649
4Increased CSF lactate (HP:0002490)4.29818141
5Hepatocellular necrosis (HP:0001404)4.09803883
6Acute encephalopathy (HP:0006846)3.98914733
7Progressive macrocephaly (HP:0004481)3.98706564
8Hepatic necrosis (HP:0002605)3.96456735
9Chromsome breakage (HP:0040012)3.55163508
10Increased hepatocellular lipid droplets (HP:0006565)3.36222374
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27153484
12Increased serum lactate (HP:0002151)3.16374992
13Volvulus (HP:0002580)2.97737961
14Lipid accumulation in hepatocytes (HP:0006561)2.97494855
15Abnormality of midbrain morphology (HP:0002418)2.90950932
16Molar tooth sign on MRI (HP:0002419)2.90950932
17Birth length less than 3rd percentile (HP:0003561)2.82101701
18Renal Fanconi syndrome (HP:0001994)2.81752212
19Asymmetry of the thorax (HP:0001555)2.76657986
20Hyperglycinemia (HP:0002154)2.75696455
21Cerebral edema (HP:0002181)2.73190462
22Cleft eyelid (HP:0000625)2.71491740
23Lactic acidosis (HP:0003128)2.70142082
24Colon cancer (HP:0003003)2.67176231
25Methylmalonic acidemia (HP:0002912)2.66901418
26Abnormal number of erythroid precursors (HP:0012131)2.66419018
27Methylmalonic aciduria (HP:0012120)2.65937813
283-Methylglutaconic aciduria (HP:0003535)2.57939794
29Poor head control (HP:0002421)2.57115167
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56294267
31Aplastic anemia (HP:0001915)2.56055667
32Lip pit (HP:0100267)2.56016863
33Abnormality of cells of the erythroid lineage (HP:0012130)2.55545181
34True hermaphroditism (HP:0010459)2.55215217
35Abnormality of the renal collecting system (HP:0004742)2.53850304
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48339734
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48339734
38Cupped ear (HP:0000378)2.44678884
39Degeneration of anterior horn cells (HP:0002398)2.43876426
40Abnormality of the anterior horn cell (HP:0006802)2.43876426
41Respiratory failure (HP:0002878)2.39822757
42Abnormality of chromosome stability (HP:0003220)2.39100002
43Congenital primary aphakia (HP:0007707)2.39023291
44Patellar aplasia (HP:0006443)2.38688146
45Exercise intolerance (HP:0003546)2.36853103
46Optic neuritis (HP:0100653)2.36588451
47Retrobulbar optic neuritis (HP:0100654)2.36588451
48Short tibia (HP:0005736)2.36299775
49Increased intramyocellular lipid droplets (HP:0012240)2.35001901
50Reticulocytopenia (HP:0001896)2.32989569
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.32384972
52Hypoplasia of the fovea (HP:0007750)2.32384972
53Hypoplastic labia majora (HP:0000059)2.30009730
54Increased serum pyruvate (HP:0003542)2.28937977
55Gait imbalance (HP:0002141)2.28085289
56Abnormality of the preputium (HP:0100587)2.26733230
57Ectopic kidney (HP:0000086)2.26421294
58Medulloblastoma (HP:0002885)2.24808021
59Aplasia/Hypoplasia of the patella (HP:0006498)2.23252558
60Septo-optic dysplasia (HP:0100842)2.22328764
61Myelodysplasia (HP:0002863)2.20513980
62Thyroiditis (HP:0100646)2.19230784
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18640328
64Abnormal protein N-linked glycosylation (HP:0012347)2.18640328
65Abnormal protein glycosylation (HP:0012346)2.18640328
66Abnormal glycosylation (HP:0012345)2.18640328
67Abnormality of the fovea (HP:0000493)2.17821433
68Lymphoma (HP:0002665)2.16859298
69Meckel diverticulum (HP:0002245)2.15120915
70Absent eyebrow (HP:0002223)2.14636722
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.14516278
72Syringomyelia (HP:0003396)2.13569065
73Spinal cord lesions (HP:0100561)2.13569065
74Abnormal lung lobation (HP:0002101)2.12868612
75Neoplasm of the adrenal cortex (HP:0100641)2.12102109
76Acute myeloid leukemia (HP:0004808)2.12085092
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11085710
78Respiratory difficulties (HP:0002880)2.10221879
79Abnormal hair whorl (HP:0010721)2.09929806
80Leukodystrophy (HP:0002415)2.09802527
81Optic disc pallor (HP:0000543)2.09742745
82Absent eyelashes (HP:0000561)2.09702582
83Intestinal atresia (HP:0011100)2.09661424
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.09586637
85Agnosia (HP:0010524)2.09009117
86Reduced antithrombin III activity (HP:0001976)2.08766034
87Sclerocornea (HP:0000647)2.08197097
88Abnormality of the labia majora (HP:0012881)2.07205538
89Abnormality of glycolysis (HP:0004366)2.07159811
90Adrenal hypoplasia (HP:0000835)2.07053272
91Popliteal pterygium (HP:0009756)2.05602405
92Abnormality of cochlea (HP:0000375)2.05448185
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05025344
94Short 4th metacarpal (HP:0010044)2.05025344
95Renal cortical cysts (HP:0000803)2.04072961
96Breast hypoplasia (HP:0003187)2.02041077
97Optic nerve coloboma (HP:0000588)2.00544429
98Abnormality of the ileum (HP:0001549)2.00374413
99Congenital stationary night blindness (HP:0007642)2.00163421
100CNS demyelination (HP:0007305)1.98825972
101Increased IgM level (HP:0003496)1.97880645
102Abnormality of urine glucose concentration (HP:0011016)1.97819036
103Glycosuria (HP:0003076)1.97819036
104Clubbing of toes (HP:0100760)1.96775011
105Nephroblastoma (Wilms tumor) (HP:0002667)1.96747851
106Stenosis of the external auditory canal (HP:0000402)1.94771585
107Anencephaly (HP:0002323)1.94062428
108Deep philtrum (HP:0002002)1.93183645
109Medial flaring of the eyebrow (HP:0010747)1.92947627
110Chronic otitis media (HP:0000389)1.92810448
111Facial cleft (HP:0002006)1.92230758
112Myositis (HP:0100614)1.91675953
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.91241379
114Absent thumb (HP:0009777)1.90024670
11511 pairs of ribs (HP:0000878)1.88085310
116Ependymoma (HP:0002888)1.87571897
117Exertional dyspnea (HP:0002875)1.86430482
118Thrombocytosis (HP:0001894)1.85828407
119Amaurosis fugax (HP:0100576)1.85536007
120Granulocytopenia (HP:0001913)1.85026288
121Proximal placement of thumb (HP:0009623)1.84753463
122Deviation of the thumb (HP:0009603)1.82938969
123Severe combined immunodeficiency (HP:0004430)1.82889413
124Embryonal renal neoplasm (HP:0011794)1.82836854
125Abnormality of the labia minora (HP:0012880)1.82454691
126Abnormality of renal resorption (HP:0011038)1.82333071
127Median cleft lip (HP:0000161)1.81693338
128Orchitis (HP:0100796)1.81683063
129Duodenal stenosis (HP:0100867)1.80411936
130Small intestinal stenosis (HP:0012848)1.80411936
131Macrocytic anemia (HP:0001972)1.80299686
132Atresia of the external auditory canal (HP:0000413)1.78566284
133Genital tract atresia (HP:0001827)1.78557905
134Preaxial hand polydactyly (HP:0001177)1.77612263
135Lethargy (HP:0001254)1.77147517
136IgM deficiency (HP:0002850)1.76341118
137Type I transferrin isoform profile (HP:0003642)1.76282103
138Eosinophilia (HP:0001880)1.76129893
139Tubulointerstitial nephritis (HP:0001970)1.75893793
140Recurrent viral infections (HP:0004429)1.75615354
141Abnormality of the renal cortex (HP:0011035)1.75409250
142Generalized aminoaciduria (HP:0002909)1.74468763
143Duplicated collecting system (HP:0000081)1.73744251
144Leukocytosis (HP:0001974)1.73235266
145Nephrogenic diabetes insipidus (HP:0009806)1.72648810
146Abnormality of eosinophils (HP:0001879)1.72575937
147Retinal dysplasia (HP:0007973)1.72386851
148Pancreatic cysts (HP:0001737)1.72031165
149Rhabdomyosarcoma (HP:0002859)1.72008951
150White forelock (HP:0002211)1.71738301
151Vaginal atresia (HP:0000148)1.71630413
152Sloping forehead (HP:0000340)1.71341451
153Increased muscle lipid content (HP:0009058)1.71117327
154Premature graying of hair (HP:0002216)1.70958033
155Aplasia/hypoplasia of the uterus (HP:0008684)1.70398017
156Impulsivity (HP:0100710)1.69707638
157Abnormality of the duodenum (HP:0002246)1.69092475
158Neoplasm of the adrenal gland (HP:0100631)1.68820118
159Abnormal number of incisors (HP:0011064)1.68189366
160Cystic liver disease (HP:0006706)1.67933352
161Abnormality of the parietal bone (HP:0002696)1.67758076
162Papillary thyroid carcinoma (HP:0002895)1.66906057
163X-linked dominant inheritance (HP:0001423)1.66879888
164Pancreatic fibrosis (HP:0100732)1.66829242
165Trigonocephaly (HP:0000243)1.64560560
166Morphological abnormality of the inner ear (HP:0011390)1.64318378
167Increased nuchal translucency (HP:0010880)1.63426210
168Absent radius (HP:0003974)1.63192349
169Stomach cancer (HP:0012126)1.62807869
170Cortical dysplasia (HP:0002539)1.60945142
171Short middle phalanx of the 5th finger (HP:0004220)1.60104861
172Recurrent abscess formation (HP:0002722)1.59609363
173Supernumerary spleens (HP:0009799)1.59408900
174Combined immunodeficiency (HP:0005387)1.59047888
175Anal stenosis (HP:0002025)1.57794052
176Abnormality of the intervertebral disk (HP:0005108)1.57779289
177Elevated erythrocyte sedimentation rate (HP:0003565)1.57401336
178Cutaneous melanoma (HP:0012056)1.56793798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.84307118
2TRIM283.28171662
3CDC73.18640305
4MKNK13.08630513
5PLK42.77776635
6BUB12.67670663
7SRPK12.66094716
8VRK12.65100779
9WNK32.49687507
10WEE12.39745620
11MKNK22.37669704
12EIF2AK12.11460465
13ZAK2.09510649
14BRSK22.08945909
15PASK2.05480539
16PLK32.02806653
17TSSK62.02306746
18EIF2AK31.94776516
19STK101.94452253
20ACVR1B1.90010128
21IRAK41.89242462
22MAP3K31.83027811
23TLK11.83006876
24TTK1.80472503
25EIF2AK21.74920437
26GRK11.70568253
27YES11.67187888
28ATR1.64706982
29FRK1.62968914
30PBK1.55747570
31MAP3K21.50933272
32ERBB31.49907122
33NEK21.46121206
34LIMK11.45353168
35MAP4K21.44049291
36PLK11.41028225
37CDK191.36953226
38STK41.31714289
39CDK71.30455233
40AURKB1.28727486
41MAP3K41.26859309
42ADRBK21.26787616
43MAP3K141.25722651
44MAP2K71.23789343
45NEK11.22102106
46TXK1.20158029
47BRD41.18493389
48CHEK21.17078275
49JAK31.16701949
50TEC1.13095725
51BCKDK1.09404625
52NEK61.09274966
53MAPK131.08985124
54BRSK11.05805786
55STK161.05641013
56RPS6KB21.03838186
57EPHA41.02227896
58TGFBR11.00536598
59PDK21.00503311
60NLK0.99420211
61CSNK1G10.98792369
62EEF2K0.98228588
63CHEK10.96511656
64MAP3K80.95302538
65STK38L0.93514122
66CSNK1G30.92274516
67MST40.91961576
68MAP3K120.91472491
69ATM0.91361742
70OXSR10.91317854
71NUAK10.91273139
72TYK20.90909195
73PIM10.87683569
74CASK0.87247963
75KIT0.87111871
76PIM20.87108127
77NME10.85656874
78MAP4K10.85311739
79PAK30.85078599
80TAOK30.84366313
81CCNB10.83886998
82CDK80.83775079
83STK30.83355220
84RPS6KA40.82538540
85MAP3K90.81724517
86CHUK0.81475162
87DYRK20.80224087
88ARAF0.79886208
89STK390.79710023
90AURKA0.79288538
91DYRK30.77768591
92MELK0.74875988
93PINK10.74341450
94IRAK30.71937492
95PLK20.70554899
96BMPR20.69898039
97CSNK1G20.69780530
98BRAF0.68616526
99BTK0.68582466
100CDK120.67906453
101NEK90.66720816
102WNK40.66427160
103SIK30.64938896
104IKBKB0.64648079
105PRKCE0.64552463
106TESK10.63603857
107BLK0.62564588
108CSNK2A20.62038102
109EPHA30.61766203
110RPS6KA50.61517666
111GRK50.60979205
112MARK30.60661706
113TESK20.59326311
114MAPKAPK20.58647784
115IKBKE0.58586375
116SYK0.58183052
117CDK40.57935931
118TNIK0.57253002
119BMPR1B0.56538414
120CDK20.54809330
121PRKCG0.51197833
122PRKCI0.50873576
123CDK10.50312737
124HIPK20.50272969
125RPS6KB10.49330335
126FLT30.48166894
127CSF1R0.47751866
128LYN0.47312129
129CSNK2A10.46305265
130MINK10.46005985
131CDK60.45806214
132BCR0.44826589
133TAF10.42967344
134CLK10.42750283
135LRRK20.42172509
136GRK70.41093737
137LCK0.39325384
138CSNK1A1L0.38802708
139SIK20.37765425
140NME20.37430046
141RAF10.37008815
142CSNK1A10.36121266
143PAK10.35892695
144DAPK10.33626071
145KSR10.33535505
146ADRBK10.31663499
147CAMK2D0.31195242

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.55130855
2Oxidative phosphorylation_Homo sapiens_hsa001903.50756223
3Mismatch repair_Homo sapiens_hsa034303.30518418
4Parkinsons disease_Homo sapiens_hsa050123.00023023
5Cell cycle_Homo sapiens_hsa041102.80153368
6Homologous recombination_Homo sapiens_hsa034402.73128251
7Spliceosome_Homo sapiens_hsa030402.44152825
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36980519
9Non-homologous end-joining_Homo sapiens_hsa034502.34569842
10RNA polymerase_Homo sapiens_hsa030202.30742537
11Base excision repair_Homo sapiens_hsa034102.29003293
12Huntingtons disease_Homo sapiens_hsa050162.25043069
13Fanconi anemia pathway_Homo sapiens_hsa034602.22393902
14Nucleotide excision repair_Homo sapiens_hsa034202.19163345
15RNA transport_Homo sapiens_hsa030132.11652600
16RNA degradation_Homo sapiens_hsa030182.10750506
17Proteasome_Homo sapiens_hsa030502.08193404
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07823922
19Folate biosynthesis_Homo sapiens_hsa007902.03599196
20Basal transcription factors_Homo sapiens_hsa030222.02362535
21Ribosome_Homo sapiens_hsa030102.01455444
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00904806
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76453094
24p53 signaling pathway_Homo sapiens_hsa041151.76296736
25Pyrimidine metabolism_Homo sapiens_hsa002401.73662476
26Alzheimers disease_Homo sapiens_hsa050101.70629222
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67404958
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63460696
29Steroid biosynthesis_Homo sapiens_hsa001001.62943526
30Herpes simplex infection_Homo sapiens_hsa051681.60072372
31One carbon pool by folate_Homo sapiens_hsa006701.58831312
32Systemic lupus erythematosus_Homo sapiens_hsa053221.58528897
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.55926660
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52799364
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.47514142
36mRNA surveillance pathway_Homo sapiens_hsa030151.42832653
37Epstein-Barr virus infection_Homo sapiens_hsa051691.41814495
38Fatty acid elongation_Homo sapiens_hsa000621.41765809
39Allograft rejection_Homo sapiens_hsa053301.40315760
40Protein export_Homo sapiens_hsa030601.40111933
41Primary immunodeficiency_Homo sapiens_hsa053401.39397684
42Antigen processing and presentation_Homo sapiens_hsa046121.38124542
43Measles_Homo sapiens_hsa051621.37284116
44Propanoate metabolism_Homo sapiens_hsa006401.32341889
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30981071
46Viral carcinogenesis_Homo sapiens_hsa052031.30887793
47Collecting duct acid secretion_Homo sapiens_hsa049661.30441467
48Sulfur metabolism_Homo sapiens_hsa009201.29177115
49Regulation of autophagy_Homo sapiens_hsa041401.27774854
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26429660
51Selenocompound metabolism_Homo sapiens_hsa004501.23662769
52Leishmaniasis_Homo sapiens_hsa051401.23238604
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.21871249
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16340334
55Sulfur relay system_Homo sapiens_hsa041221.13448198
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.12939690
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12790398
58Legionellosis_Homo sapiens_hsa051341.12304673
59Phototransduction_Homo sapiens_hsa047441.10547611
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10331496
61Pyruvate metabolism_Homo sapiens_hsa006201.09078703
62Graft-versus-host disease_Homo sapiens_hsa053321.06902716
63Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04689208
64Cardiac muscle contraction_Homo sapiens_hsa042601.04550176
65NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04017350
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99985125
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98980941
68Butanoate metabolism_Homo sapiens_hsa006500.98780914
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98765483
70Hepatitis B_Homo sapiens_hsa051610.98098213
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96749845
72HTLV-I infection_Homo sapiens_hsa051660.96317425
73MicroRNAs in cancer_Homo sapiens_hsa052060.93865934
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92844456
75Influenza A_Homo sapiens_hsa051640.88894045
76Peroxisome_Homo sapiens_hsa041460.88406113
77Autoimmune thyroid disease_Homo sapiens_hsa053200.88378612
78Purine metabolism_Homo sapiens_hsa002300.86629035
79Type I diabetes mellitus_Homo sapiens_hsa049400.82438484
80Thyroid cancer_Homo sapiens_hsa052160.82140091
81Glutathione metabolism_Homo sapiens_hsa004800.81982388
82Small cell lung cancer_Homo sapiens_hsa052220.81232710
83Apoptosis_Homo sapiens_hsa042100.80975957
84Hematopoietic cell lineage_Homo sapiens_hsa046400.80696089
85Metabolic pathways_Homo sapiens_hsa011000.79762183
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77328556
87Asthma_Homo sapiens_hsa053100.75576109
88Alcoholism_Homo sapiens_hsa050340.75170446
89TGF-beta signaling pathway_Homo sapiens_hsa043500.69937913
90Shigellosis_Homo sapiens_hsa051310.69916944
91Vitamin B6 metabolism_Homo sapiens_hsa007500.68691565
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.68255756
93Chronic myeloid leukemia_Homo sapiens_hsa052200.67823763
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67314177
95Malaria_Homo sapiens_hsa051440.67304737
96Caffeine metabolism_Homo sapiens_hsa002320.65854833
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65198564
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64502302
99Prostate cancer_Homo sapiens_hsa052150.64405442
100Toxoplasmosis_Homo sapiens_hsa051450.63155001
101Colorectal cancer_Homo sapiens_hsa052100.60850030
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60078052
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59893840
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59747194
105Oocyte meiosis_Homo sapiens_hsa041140.59589306
106Viral myocarditis_Homo sapiens_hsa054160.59289073
107TNF signaling pathway_Homo sapiens_hsa046680.58950976
108B cell receptor signaling pathway_Homo sapiens_hsa046620.58352437
109T cell receptor signaling pathway_Homo sapiens_hsa046600.57794931
110Pancreatic cancer_Homo sapiens_hsa052120.57765723
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.57761769
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54917841
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54253896
114Acute myeloid leukemia_Homo sapiens_hsa052210.50441018
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48760869
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48081859
117Adherens junction_Homo sapiens_hsa045200.47726115
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47480692
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47320958
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46652574
121Chemokine signaling pathway_Homo sapiens_hsa040620.44570670
122Pathways in cancer_Homo sapiens_hsa052000.44546038
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42648161
124African trypanosomiasis_Homo sapiens_hsa051430.42342374
125Vibrio cholerae infection_Homo sapiens_hsa051100.42156287
126Pertussis_Homo sapiens_hsa051330.41761580
127Carbon metabolism_Homo sapiens_hsa012000.41340781
128Linoleic acid metabolism_Homo sapiens_hsa005910.41201880
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.40234716
130Osteoclast differentiation_Homo sapiens_hsa043800.39292220
131Hepatitis C_Homo sapiens_hsa051600.39267264
132Phagosome_Homo sapiens_hsa041450.39221127
133Hippo signaling pathway_Homo sapiens_hsa043900.38854850
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38163917
135Notch signaling pathway_Homo sapiens_hsa043300.37849585
136Ether lipid metabolism_Homo sapiens_hsa005650.37526640
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37001875
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36733415
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36246666
140Endometrial cancer_Homo sapiens_hsa052130.35230372
141Melanoma_Homo sapiens_hsa052180.35183723
142Prolactin signaling pathway_Homo sapiens_hsa049170.35000345
143FoxO signaling pathway_Homo sapiens_hsa040680.34956635
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34634170
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33832246
146Fructose and mannose metabolism_Homo sapiens_hsa000510.33087312
147Fatty acid metabolism_Homo sapiens_hsa012120.33058442
148Rheumatoid arthritis_Homo sapiens_hsa053230.32831056
149Basal cell carcinoma_Homo sapiens_hsa052170.32607282
150Tuberculosis_Homo sapiens_hsa051520.32550794
151Nitrogen metabolism_Homo sapiens_hsa009100.31543785
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31300024
153Tryptophan metabolism_Homo sapiens_hsa003800.31211942
154Biosynthesis of amino acids_Homo sapiens_hsa012300.29205397
155N-Glycan biosynthesis_Homo sapiens_hsa005100.27780441
156Chemical carcinogenesis_Homo sapiens_hsa052040.18488295
157Olfactory transduction_Homo sapiens_hsa047400.16771039
1582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16667431
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14114783
160Taste transduction_Homo sapiens_hsa047420.12121966
161Arachidonic acid metabolism_Homo sapiens_hsa005900.11826626
162Nicotine addiction_Homo sapiens_hsa050330.11416448
163Synaptic vesicle cycle_Homo sapiens_hsa047210.10646458
164beta-Alanine metabolism_Homo sapiens_hsa004100.10454887

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