TTC33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.39891172
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.16066545
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.02628965
4ATP synthesis coupled proton transport (GO:0015986)5.02628965
5DNA double-strand break processing (GO:0000729)4.85727912
6energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.83253598
7ATP hydrolysis coupled proton transport (GO:0015991)4.83253598
8kynurenine metabolic process (GO:0070189)4.83187718
9neuron cell-cell adhesion (GO:0007158)4.75990578
10synaptic vesicle exocytosis (GO:0016079)4.68809874
11positive regulation of mitotic sister chromatid separation (GO:1901970)4.68263541
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.68263541
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.68263541
14presynaptic membrane assembly (GO:0097105)4.54701183
15non-recombinational repair (GO:0000726)4.42905198
16double-strand break repair via nonhomologous end joining (GO:0006303)4.42905198
17presynaptic membrane organization (GO:0097090)4.42181752
18respiratory electron transport chain (GO:0022904)4.34352849
19chaperone-mediated protein transport (GO:0072321)4.33674166
20transferrin transport (GO:0033572)4.28146917
21electron transport chain (GO:0022900)4.25772235
22neuronal action potential propagation (GO:0019227)4.05600892
23indole-containing compound catabolic process (GO:0042436)4.03729727
24indolalkylamine catabolic process (GO:0046218)4.03729727
25tryptophan catabolic process (GO:0006569)4.03729727
26ferric iron transport (GO:0015682)3.97503953
27trivalent inorganic cation transport (GO:0072512)3.97503953
28vocalization behavior (GO:0071625)3.95615168
29regulation of synaptic vesicle exocytosis (GO:2000300)3.93133469
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.91290756
31protein localization to synapse (GO:0035418)3.75758292
32protein complex biogenesis (GO:0070271)3.75202623
33protein neddylation (GO:0045116)3.72750364
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71475047
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.64674963
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.63585463
37positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.61873743
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.60136392
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56453267
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.56453267
41NADH dehydrogenase complex assembly (GO:0010257)3.56453267
42glutamate secretion (GO:0014047)3.54260417
43positive regulation of mitochondrial fission (GO:0090141)3.54068010
44regulation of synaptic vesicle transport (GO:1902803)3.50978634
45phagosome maturation (GO:0090382)3.49305824
46mitochondrial DNA replication (GO:0006264)3.41677958
47NADH metabolic process (GO:0006734)3.39528764
48behavioral response to cocaine (GO:0048148)3.36368676
49tryptophan metabolic process (GO:0006568)3.34426288
50protein localization to cilium (GO:0061512)3.34294282
51regulation of hexokinase activity (GO:1903299)3.32828324
52regulation of glucokinase activity (GO:0033131)3.32828324
53neuron-neuron synaptic transmission (GO:0007270)3.30772854
54regulation of glutamate secretion (GO:0014048)3.30723204
55ribonucleoprotein complex disassembly (GO:0032988)3.30597077
56mitochondrial respiratory chain complex assembly (GO:0033108)3.29502627
57polyol catabolic process (GO:0046174)3.29417973
58cellular biogenic amine catabolic process (GO:0042402)3.28099786
59amine catabolic process (GO:0009310)3.28099786
60microtubule depolymerization (GO:0007019)3.27513825
61indolalkylamine metabolic process (GO:0006586)3.27128638
62hydrogen ion transmembrane transport (GO:1902600)3.26649711
63succinate metabolic process (GO:0006105)3.26129553
64response to histamine (GO:0034776)3.24627258
65female mating behavior (GO:0060180)3.22449771
66regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.21147914
67regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.21147914
68neurotransmitter secretion (GO:0007269)3.18524852
69negative regulation of dendrite morphogenesis (GO:0050774)3.18247431
70positive regulation of synapse assembly (GO:0051965)3.18002982
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17105872
72transcription from mitochondrial promoter (GO:0006390)3.16532828
73positive regulation of neurotransmitter transport (GO:0051590)3.13778699
74neurotransmitter-gated ion channel clustering (GO:0072578)3.12283976
75cullin deneddylation (GO:0010388)3.10120508
76inner mitochondrial membrane organization (GO:0007007)3.10085197
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05491182
78dopamine transport (GO:0015872)3.05079994
79pyrimidine nucleobase catabolic process (GO:0006208)3.04495810
80organelle disassembly (GO:1903008)3.01258787
81proton transport (GO:0015992)3.00861010
82negative regulation of neurotransmitter transport (GO:0051589)3.00758207
83respiratory chain complex IV assembly (GO:0008535)2.98587859
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97834230
85mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.97359202
86positive regulation of glycolytic process (GO:0045821)2.96248887
87detection of calcium ion (GO:0005513)2.96207007
88ionotropic glutamate receptor signaling pathway (GO:0035235)2.95955545
89hydrogen transport (GO:0006818)2.95946267
90adenosine metabolic process (GO:0046085)2.94368825
91negative regulation of heart rate (GO:0010459)2.94311289
92glutamate receptor signaling pathway (GO:0007215)2.92710154
93regulation of protein kinase A signaling (GO:0010738)2.92274387
94startle response (GO:0001964)2.91951107
95neurotransmitter uptake (GO:0001504)2.91227334
96inositol phosphate catabolic process (GO:0071545)2.90347567
97fatty acid elongation (GO:0030497)2.89318650
98regulation of cell communication by electrical coupling (GO:0010649)2.88607457
99positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88153787
100synaptic transmission, dopaminergic (GO:0001963)2.87762405
101striatum development (GO:0021756)2.87162087
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87142455
103negative regulation of membrane potential (GO:0045837)2.86862394
104regulation of dopamine metabolic process (GO:0042053)2.86463596
105regulation of catecholamine metabolic process (GO:0042069)2.86463596
106regulation of glutamate receptor signaling pathway (GO:1900449)2.86448578
107behavioral response to nicotine (GO:0035095)2.86167745
108postsynaptic membrane organization (GO:0001941)2.85392982
109regulation of meiosis I (GO:0060631)2.85264600
110protein deneddylation (GO:0000338)2.85183577
111synaptic transmission, glutamatergic (GO:0035249)2.84992093
112neurotransmitter transport (GO:0006836)2.84111284
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83827616
114positive regulation of chromosome segregation (GO:0051984)2.83146761
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.83067300
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.79523139
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79396754
118long-term synaptic potentiation (GO:0060291)2.78115079
119regulation of mitochondrial fission (GO:0090140)2.76973084
120positive regulation of neurotransmitter secretion (GO:0001956)2.76621903
121regulation of female receptivity (GO:0045924)2.76559035
122protein-cofactor linkage (GO:0018065)2.76438532
123maturation of 5.8S rRNA (GO:0000460)2.75950560
124response to cocaine (GO:0042220)2.75263609
125regulation of relaxation of muscle (GO:1901077)2.74395403
126regulation of acyl-CoA biosynthetic process (GO:0050812)2.72446807
127neural tube formation (GO:0001841)2.72049646
128ATP biosynthetic process (GO:0006754)2.71929103
129nonmotile primary cilium assembly (GO:0035058)2.71117977
130establishment of synaptic vesicle localization (GO:0097480)2.71042927
131synaptic vesicle transport (GO:0048489)2.71042927
132cytochrome complex assembly (GO:0017004)2.70862339
133piRNA metabolic process (GO:0034587)2.70781976
134regulation of neurotransmitter secretion (GO:0046928)2.68911758
135regulation of cofactor metabolic process (GO:0051193)2.68365189
136regulation of coenzyme metabolic process (GO:0051196)2.68365189
137regulation of vesicle fusion (GO:0031338)2.66978397
138regulation of oxidative phosphorylation (GO:0002082)2.66752187
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66629493
140isotype switching (GO:0045190)2.66629493
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66629493
142regulation of neurotransmitter levels (GO:0001505)2.66476191
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.65984203
144benzene-containing compound metabolic process (GO:0042537)2.65212579
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65102704
146oxaloacetate metabolic process (GO:0006107)2.65002346
147nucleobase catabolic process (GO:0046113)2.64925386
148cellular ketone body metabolic process (GO:0046950)2.64744739
149inositol phosphate dephosphorylation (GO:0046855)2.64110438
150phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64110438
151synapsis (GO:0007129)2.60207757
152regulation of sulfur metabolic process (GO:0042762)2.58329866
153beta-amyloid metabolic process (GO:0050435)2.55864850
154regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.55674223
155positive regulation of protein homodimerization activity (GO:0090073)2.54427322
156regulation of sister chromatid cohesion (GO:0007063)2.53312150
157positive regulation of DNA repair (GO:0045739)2.48538875
158negative regulation of cell aging (GO:0090344)2.48365331
159epithelial cilium movement (GO:0003351)2.45239988
160protein K6-linked ubiquitination (GO:0085020)2.44890660
161positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44208135
162platelet dense granule organization (GO:0060155)2.42320746
163indole-containing compound metabolic process (GO:0042430)2.42050537
164negative regulation of neurological system process (GO:0031645)2.41292245
165ketone body metabolic process (GO:1902224)2.40766498
166meiotic chromosome segregation (GO:0045132)2.40481179
167negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.40389596
168detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40219220
169protein prenylation (GO:0018342)2.40127572
170prenylation (GO:0097354)2.40127572
171GMP metabolic process (GO:0046037)2.39022934
172DNA-dependent DNA replication (GO:0006261)2.38744845
173DNA catabolic process, exonucleolytic (GO:0000738)2.37133053
174DNA integration (GO:0015074)2.34896505
175recombinational repair (GO:0000725)2.34044640
176replication fork processing (GO:0031297)2.33264938
177histone H2A ubiquitination (GO:0033522)2.32549340
178resolution of meiotic recombination intermediates (GO:0000712)2.31185181
179cilium organization (GO:0044782)2.31125650
180peptidyl-histidine modification (GO:0018202)2.28152032
181sequestering of actin monomers (GO:0042989)2.27960151
182double-strand break repair via homologous recombination (GO:0000724)2.27704779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44977804
2GBX2_23144817_ChIP-Seq_PC3_Human4.28786523
3TAF15_26573619_Chip-Seq_HEK293_Human3.75046764
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75335048
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71398427
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.59231969
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50403946
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41302014
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31731880
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22516561
11P300_19829295_ChIP-Seq_ESCs_Human2.16350821
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15358142
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15094434
14VDR_22108803_ChIP-Seq_LS180_Human2.14596798
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12844007
16* FUS_26573619_Chip-Seq_HEK293_Human2.07237998
17REST_21632747_ChIP-Seq_MESCs_Mouse2.05773794
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96634509
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95334175
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94292414
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94259905
22IGF1R_20145208_ChIP-Seq_DFB_Human1.91598735
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90133535
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88086040
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86708308
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86053865
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.85192426
28SMAD4_21799915_ChIP-Seq_A2780_Human1.85061627
29ER_23166858_ChIP-Seq_MCF-7_Human1.79135130
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78845315
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77779002
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76969507
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.75675134
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74901205
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.74297247
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71646696
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.71123400
38ELK1_19687146_ChIP-ChIP_HELA_Human1.69081063
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67015606
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65582235
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65001394
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62531890
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61904919
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57756039
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.56594775
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56355955
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.55414741
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.54360214
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54160199
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54070667
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52339523
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52280428
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.51737172
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51126758
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50612448
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.50023112
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47975306
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.46753019
59RNF2_27304074_Chip-Seq_NSC_Mouse1.46633132
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42961617
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42961617
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.42954219
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42239201
64EWS_26573619_Chip-Seq_HEK293_Human1.42172363
65ZNF274_21170338_ChIP-Seq_K562_Hela1.41063986
66CBP_20019798_ChIP-Seq_JUKART_Human1.37856880
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37856880
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36869031
69AR_25329375_ChIP-Seq_VCAP_Human1.36739055
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36654371
71BCAT_22108803_ChIP-Seq_LS180_Human1.35392356
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32593441
73TP53_22573176_ChIP-Seq_HFKS_Human1.31792402
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.28837750
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.27962427
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27642201
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27446988
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.26707388
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.26537781
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25632892
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25033546
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.24847627
83* JUN_21703547_ChIP-Seq_K562_Human1.24469187
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23222695
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22760782
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22487984
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22094801
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20814402
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19496299
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18000588
91* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17624233
92HTT_18923047_ChIP-ChIP_STHdh_Human1.17360347
93* TAL1_26923725_Chip-Seq_HPCs_Mouse1.16778040
94AR_21572438_ChIP-Seq_LNCaP_Human1.16542573
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16109619
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.16064083
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14143523
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13612253
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13569560
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13365912
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13194070
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.13190243
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.12748710
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12643326
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12330146
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12265040
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12134722
108SALL4_22934838_ChIP-ChIP_CD34+_Human1.11977406
109P300_18555785_Chip-Seq_ESCs_Mouse1.11117894
110* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11021733
111* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11021733
112P53_22387025_ChIP-Seq_ESCs_Mouse1.10793774
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10663499
114REST_19997604_ChIP-ChIP_NEURONS_Mouse1.10648730
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10640842
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10517404
117STAT3_23295773_ChIP-Seq_U87_Human1.10413234
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09252402
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09166049
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.08964280
121TCF4_22108803_ChIP-Seq_LS180_Human1.08271646
122OCT4_18555785_Chip-Seq_ESCs_Mouse1.08254693
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08186191
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.07745168
125* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07582059
126* VDR_23849224_ChIP-Seq_CD4+_Human1.07350153
127HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07310558
128NANOG_19829295_ChIP-Seq_ESCs_Human1.06941542
129SOX2_19829295_ChIP-Seq_ESCs_Human1.06941542
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06646384
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06593106
132TCF4_23295773_ChIP-Seq_U87_Human1.05964331
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.05907850
134RUNX2_22187159_ChIP-Seq_PCA_Human1.04970993
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.04567144
136EZH2_27294783_Chip-Seq_ESCs_Mouse1.04002461
137NMYC_18555785_Chip-Seq_ESCs_Mouse1.03859373
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.03397260
139* CDX2_22108803_ChIP-Seq_LS180_Human1.02323770
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.02056690
141MYC_18940864_ChIP-ChIP_HL60_Human1.01889361
142SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01167139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.71066840
2MP0004859_abnormal_synaptic_plasticity3.47576182
3MP0000569_abnormal_digit_pigmentation3.46660718
4MP0004270_analgesia3.21797631
5MP0002102_abnormal_ear_morphology3.18106896
6MP0003635_abnormal_synaptic_transmissio3.11661304
7MP0009046_muscle_twitch3.06756344
8MP0002064_seizures2.95429470
9MP0009745_abnormal_behavioral_response2.94216149
10MP0006276_abnormal_autonomic_nervous2.92219162
11MP0002837_dystrophic_cardiac_calcinosis2.84464542
12MP0001529_abnormal_vocalization2.78479856
13MP0008875_abnormal_xenobiotic_pharmacok2.75519499
14MP0001968_abnormal_touch/_nociception2.71037255
15MP0002272_abnormal_nervous_system2.62981950
16MP0002063_abnormal_learning/memory/cond2.57234492
17MP0002735_abnormal_chemical_nociception2.54235911
18MP0002736_abnormal_nociception_after2.53278069
19MP0002572_abnormal_emotion/affect_behav2.51595114
20MP0002734_abnormal_mechanical_nocicepti2.48302397
21MP0005646_abnormal_pituitary_gland2.43016635
22MP0001440_abnormal_grooming_behavior2.37838007
23MP0002822_catalepsy2.36499729
24MP0001905_abnormal_dopamine_level2.36022751
25MP0008057_abnormal_DNA_replication2.31351880
26MP0001501_abnormal_sleep_pattern2.30673274
27MP0001984_abnormal_olfaction2.11675311
28MP0008058_abnormal_DNA_repair2.07603528
29MP0005253_abnormal_eye_physiology2.07473274
30MP0002067_abnormal_sensory_capabilities1.97121366
31MP0002876_abnormal_thyroid_physiology1.96111187
32MP0003787_abnormal_imprinting1.93691389
33MP0003122_maternal_imprinting1.91875627
34MP0001486_abnormal_startle_reflex1.89730987
35MP0005379_endocrine/exocrine_gland_phen1.86703842
36MP0005386_behavior/neurological_phenoty1.81647049
37MP0004924_abnormal_behavior1.81647049
38MP0001970_abnormal_pain_threshold1.81568808
39MP0004142_abnormal_muscle_tone1.80830354
40MP0005464_abnormal_platelet_physiology1.79889786
41MP0002733_abnormal_thermal_nociception1.79396419
42MP0002163_abnormal_gland_morphology1.65631274
43MP0010386_abnormal_urinary_bladder1.59875912
44MP0005645_abnormal_hypothalamus_physiol1.55556583
45MP0003329_amyloid_beta_deposits1.48791103
46MP0003656_abnormal_erythrocyte_physiolo1.48283042
47MP0005083_abnormal_biliary_tract1.47677674
48MP0002184_abnormal_innervation1.46041494
49MP0002928_abnormal_bile_duct1.45334362
50MP0004084_abnormal_cardiac_muscle1.44550525
51MP0003879_abnormal_hair_cell1.44465967
52MP0001986_abnormal_taste_sensitivity1.42986393
53MP0009780_abnormal_chondrocyte_physiolo1.41515130
54MP0008775_abnormal_heart_ventricle1.40275180
55MP0002557_abnormal_social/conspecific_i1.39820209
56MP0010094_abnormal_chromosome_stability1.35030002
57MP0003646_muscle_fatigue1.34279342
58MP0000013_abnormal_adipose_tissue1.32367753
59MP0005423_abnormal_somatic_nervous1.32065500
60MP0005174_abnormal_tail_pigmentation1.31756019
61MP0008877_abnormal_DNA_methylation1.27714685
62MP0006036_abnormal_mitochondrial_physio1.26566105
63MP0004145_abnormal_muscle_electrophysio1.23083682
64MP0000516_abnormal_urinary_system1.19495286
65MP0005367_renal/urinary_system_phenotyp1.19495286
66MP0000778_abnormal_nervous_system1.18996007
67MP0002066_abnormal_motor_capabilities/c1.18561299
68MP0000751_myopathy1.17996603
69MP0001188_hyperpigmentation1.16747389
70MP0008004_abnormal_stomach_pH1.14172895
71MP0003718_maternal_effect1.13478391
72MP0006035_abnormal_mitochondrial_morpho1.13208236
73MP0008260_abnormal_autophagy1.13158800
74MP0003186_abnormal_redox_activity1.12109523
75MP0008569_lethality_at_weaning1.11749725
76MP0005551_abnormal_eye_electrophysiolog1.11207415
77MP0001502_abnormal_circadian_rhythm1.10710507
78MP0005167_abnormal_blood-brain_barrier1.10071960
79MP0004811_abnormal_neuron_physiology1.07955832
80MP0000427_abnormal_hair_cycle1.07302263
81MP0002638_abnormal_pupillary_reflex1.06726375
82MP0002882_abnormal_neuron_morphology1.06244565
83MP0000372_irregular_coat_pigmentation1.05942083
84MP0004215_abnormal_myocardial_fiber1.05721297
85MP0000015_abnormal_ear_pigmentation1.05260209
86MP0000955_abnormal_spinal_cord1.05071688
87MP0005535_abnormal_body_temperature1.04195794
88MP0004036_abnormal_muscle_relaxation1.03473474
89MP0001919_abnormal_reproductive_system1.03308194
90MP0002332_abnormal_exercise_endurance1.01225401
91MP0005389_reproductive_system_phenotype1.01058235
92MP0006054_spinal_hemorrhage0.99506447
93MP0003633_abnormal_nervous_system0.98757899
94MP0002229_neurodegeneration0.98442981
95MP0002938_white_spotting0.97353613
96MP0005171_absent_coat_pigmentation0.96984684
97MP0001963_abnormal_hearing_physiology0.96877785
98MP0002909_abnormal_adrenal_gland0.95715752
99MP0010234_abnormal_vibrissa_follicle0.95089643
100MP0005620_abnormal_muscle_contractility0.93718760
101MP0003183_abnormal_peptide_metabolism0.93670545
102MP0003631_nervous_system_phenotype0.92785896
103MP0001929_abnormal_gametogenesis0.89794973
104MP0001661_extended_life_span0.89523516
105MP0003121_genomic_imprinting0.87424424
106MP0000604_amyloidosis0.87393911
107MP0004742_abnormal_vestibular_system0.86201694
108MP0003698_abnormal_male_reproductive0.85750707
109MP0006072_abnormal_retinal_apoptosis0.85731520
110MP0004484_altered_response_of0.85189609
111MP0002972_abnormal_cardiac_muscle0.85184118
112MP0000631_abnormal_neuroendocrine_gland0.84901348
113MP0005220_abnormal_exocrine_pancreas0.83963917
114MP0003137_abnormal_impulse_conducting0.82327987
115MP0005266_abnormal_metabolism0.81546375
116MP0002095_abnormal_skin_pigmentation0.81254932
117MP0002210_abnormal_sex_determination0.81126343
118MP0002751_abnormal_autonomic_nervous0.80775933
119MP0005499_abnormal_olfactory_system0.79630955
120MP0005394_taste/olfaction_phenotype0.79630955
121MP0005187_abnormal_penis_morphology0.79259300
122MP0004130_abnormal_muscle_cell0.78125508
123MP0003724_increased_susceptibility_to0.77259852
124MP0000653_abnormal_sex_gland0.76549659
125MP0005391_vision/eye_phenotype0.76088580
126MP0008874_decreased_physiological_sensi0.75974720
127MP0004085_abnormal_heartbeat0.75589537
128MP0008872_abnormal_physiological_respon0.75320870
129MP0000749_muscle_degeneration0.74859729
130MP0002069_abnormal_eating/drinking_beha0.74544669
131MP0000920_abnormal_myelination0.73825347
132MP0004043_abnormal_pH_regulation0.73767991
133MP0003123_paternal_imprinting0.72558726
134MP0002752_abnormal_somatic_nervous0.70788043
135MP0009697_abnormal_copulation0.70433557
136MP0004147_increased_porphyrin_level0.69874220
137MP0001485_abnormal_pinna_reflex0.69448025
138MP0005084_abnormal_gallbladder_morpholo0.67284641
139MP0001764_abnormal_homeostasis0.66375454
140MP0000230_abnormal_systemic_arterial0.64101686
141MP0003634_abnormal_glial_cell0.62861835
142MP0002152_abnormal_brain_morphology0.62825446
143MP0002160_abnormal_reproductive_system0.62580823

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90332159
2Acute necrotizing encephalopathy (HP:0006965)5.69095546
3Abnormal mitochondria in muscle tissue (HP:0008316)5.31929734
4Progressive macrocephaly (HP:0004481)5.07011828
5Atonic seizures (HP:0010819)4.75551928
6Mitochondrial inheritance (HP:0001427)4.71370051
7Acute encephalopathy (HP:0006846)4.56697942
8Increased CSF lactate (HP:0002490)4.11909104
9Increased serum pyruvate (HP:0003542)4.03885496
10Abnormality of glycolysis (HP:0004366)4.03885496
11Pheochromocytoma (HP:0002666)4.01413018
12Neuroendocrine neoplasm (HP:0100634)4.01263109
13Hepatocellular necrosis (HP:0001404)3.83358643
14Epileptic encephalopathy (HP:0200134)3.67313846
15Febrile seizures (HP:0002373)3.62260601
16Abnormal hair whorl (HP:0010721)3.61405178
17Hypothermia (HP:0002045)3.61183482
18Myokymia (HP:0002411)3.42774758
19Absence seizures (HP:0002121)3.41987816
20Gait imbalance (HP:0002141)3.34937847
21Focal seizures (HP:0007359)3.33394829
22Congenital primary aphakia (HP:0007707)3.26578015
23Medial flaring of the eyebrow (HP:0010747)3.16249452
24Increased hepatocellular lipid droplets (HP:0006565)3.12322531
25Nephrogenic diabetes insipidus (HP:0009806)3.11125520
26Cerebral edema (HP:0002181)3.10357888
27Hyperventilation (HP:0002883)3.10246399
28Hepatic necrosis (HP:0002605)3.09545301
29Dialeptic seizures (HP:0011146)3.06644232
30Visual hallucinations (HP:0002367)3.04723110
31Pancreatic cysts (HP:0001737)3.04416642
32Optic disc pallor (HP:0000543)2.97131155
33Renal Fanconi syndrome (HP:0001994)2.86953225
34Leukodystrophy (HP:0002415)2.85116705
35Increased mean platelet volume (HP:0011877)2.85087091
36True hermaphroditism (HP:0010459)2.81958618
37Lactic acidosis (HP:0003128)2.79819918
38Generalized tonic-clonic seizures (HP:0002069)2.77593569
39Progressive inability to walk (HP:0002505)2.76186517
40Respiratory failure (HP:0002878)2.74235309
41Exercise intolerance (HP:0003546)2.73912526
42Lipid accumulation in hepatocytes (HP:0006561)2.67916844
43Oligomenorrhea (HP:0000876)2.63294327
44Limb dystonia (HP:0002451)2.63204778
45Genital tract atresia (HP:0001827)2.59920098
46Vaginal atresia (HP:0000148)2.56707628
47Abnormality of methionine metabolism (HP:0010901)2.54307107
48Ketoacidosis (HP:0001993)2.52427219
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47628437
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47628437
51Abnormality of midbrain morphology (HP:0002418)2.44966560
52Molar tooth sign on MRI (HP:0002419)2.44966560
53Poor coordination (HP:0002370)2.44054651
54Prolonged bleeding time (HP:0003010)2.43436041
55Increased intramyocellular lipid droplets (HP:0012240)2.43152104
56Abnormality of the renal cortex (HP:0011035)2.42496307
57Abnormal platelet volume (HP:0011876)2.40883856
58Dyschromatopsia (HP:0007641)2.40739679
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.37541597
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37541597
61Poor suck (HP:0002033)2.33710667
62Tongue fasciculations (HP:0001308)2.32635588
63Broad-based gait (HP:0002136)2.32418622
64Failure to thrive in infancy (HP:0001531)2.32195256
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31093167
66Inability to walk (HP:0002540)2.29322478
67Tubulointerstitial fibrosis (HP:0005576)2.28719758
68Scanning speech (HP:0002168)2.28704439
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28569365
70X-linked dominant inheritance (HP:0001423)2.28418317
71Increased serum lactate (HP:0002151)2.25921122
72Abnormality of alanine metabolism (HP:0010916)2.22749067
73Hyperalaninemia (HP:0003348)2.22749067
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22749067
75Anxiety (HP:0000739)2.20989438
76Thyroid carcinoma (HP:0002890)2.19896816
77Progressive cerebellar ataxia (HP:0002073)2.19418122
783-Methylglutaconic aciduria (HP:0003535)2.19264482
79Cerebral hemorrhage (HP:0001342)2.17739302
80Polyphagia (HP:0002591)2.15042270
81Abnormal biliary tract physiology (HP:0012439)2.14602379
82Bile duct proliferation (HP:0001408)2.14602379
83Amblyopia (HP:0000646)2.13874556
84Short tibia (HP:0005736)2.13278029
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.11665144
86Pancreatic islet-cell hyperplasia (HP:0004510)2.11457538
87Esotropia (HP:0000565)2.10824070
88Abnormality of the labia minora (HP:0012880)2.10429216
89Hemiparesis (HP:0001269)2.10291568
90Retinal dysplasia (HP:0007973)2.09591514
91Intestinal atresia (HP:0011100)2.09570228
92Abnormality of vitamin B metabolism (HP:0004340)2.04226390
93Delusions (HP:0000746)2.03827462
94Respiratory difficulties (HP:0002880)2.03131753
95CNS demyelination (HP:0007305)2.02117205
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00761605
97Specific learning disability (HP:0001328)2.00515932
98Abnormal eating behavior (HP:0100738)1.98740374
99Nephronophthisis (HP:0000090)1.98222658
100Truncal ataxia (HP:0002078)1.97778616
101Autoamputation (HP:0001218)1.97097519
102Pancreatic fibrosis (HP:0100732)1.96684219
103Chronic hepatic failure (HP:0100626)1.95992456
104Impaired vibration sensation in the lower limbs (HP:0002166)1.95701315
105Renal cortical cysts (HP:0000803)1.95076195
106Epileptiform EEG discharges (HP:0011182)1.95065742
107Cutaneous melanoma (HP:0012056)1.94550049
108Emotional lability (HP:0000712)1.93084744
109Tubulointerstitial abnormality (HP:0001969)1.92779033
110Nemaline bodies (HP:0003798)1.92731628
111Petechiae (HP:0000967)1.92666524
112Abnormality of the vitamin B12 metabolism (HP:0004341)1.91484633
113Menorrhagia (HP:0000132)1.91086699
114Abnormality of serum amino acid levels (HP:0003112)1.90820713
115Abnormality of renal resorption (HP:0011038)1.90780541
116Homocystinuria (HP:0002156)1.90489330
117Abnormality of homocysteine metabolism (HP:0010919)1.90489330
118Fetal akinesia sequence (HP:0001989)1.89188179
119Abnormality of the renal medulla (HP:0100957)1.89075834
120Muscle fibrillation (HP:0010546)1.88997975
121Papillary thyroid carcinoma (HP:0002895)1.87377108
122Increased muscle lipid content (HP:0009058)1.86990381
123Fibular aplasia (HP:0002990)1.85448887
124Muscle fiber inclusion bodies (HP:0100299)1.85384116
125Abnormal drinking behavior (HP:0030082)1.85211601
126Polydipsia (HP:0001959)1.85211601
127Thyroid-stimulating hormone excess (HP:0002925)1.82913413
128Delayed gross motor development (HP:0002194)1.82549963
129Hyperinsulinemic hypoglycemia (HP:0000825)1.81934462
130Thyroiditis (HP:0100646)1.80261799
131Abnormality of the corticospinal tract (HP:0002492)1.79596331
132Methylmalonic acidemia (HP:0002912)1.79397430
133Congenital stationary night blindness (HP:0007642)1.79176226
134Exercise-induced muscle cramps (HP:0003710)1.78599239
135Tetraparesis (HP:0002273)1.78506026
136Congenital sensorineural hearing impairment (HP:0008527)1.78321001
137EEG with generalized epileptiform discharges (HP:0011198)1.77994593
138Type 2 muscle fiber atrophy (HP:0003554)1.77432871
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.76893223
140Microvesicular hepatic steatosis (HP:0001414)1.76576474
141Male pseudohermaphroditism (HP:0000037)1.76169368
142Aplasia/Hypoplasia of the lens (HP:0008063)1.75193175
143Neoplasm of the peripheral nervous system (HP:0100007)1.74730928
144Postaxial hand polydactyly (HP:0001162)1.74177947
145Muscle hypertrophy of the lower extremities (HP:0008968)1.73701519
146Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73025683
147Diplopia (HP:0000651)1.72694672
148Abnormality of binocular vision (HP:0011514)1.72694672
149Fair hair (HP:0002286)1.72341449
150Insidious onset (HP:0003587)1.72141737
151Termporal pattern (HP:0011008)1.72141737
152Myotonia (HP:0002486)1.72102739
153Postaxial foot polydactyly (HP:0001830)1.71618736
154Long clavicles (HP:0000890)1.70936352
155Psychosis (HP:0000709)1.70869580
156Spastic gait (HP:0002064)1.70134458
157Megaloblastic anemia (HP:0001889)1.69777949
158Methylmalonic aciduria (HP:0012120)1.69619266
159Rimmed vacuoles (HP:0003805)1.67557634
160Poikilocytosis (HP:0004447)1.67031564
161Hyperglycemia (HP:0003074)1.66384201
162Abnormal autonomic nervous system physiology (HP:0012332)1.65695295
163Attenuation of retinal blood vessels (HP:0007843)1.64861957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33066223
2MAP3K123.57098960
3MAP2K73.23002831
4MAP3K43.18153200
5ARAF3.04331011
6TRIM282.92491072
7NTRK32.85115552
8PNCK2.55763948
9NME12.42236349
10ERBB32.33608354
11PLK22.25667745
12NUAK12.22601733
13CDK192.12532615
14TSSK62.07838245
15OXSR11.99267831
16RIPK41.92110038
17ACVR1B1.89502597
18MAP2K41.86492675
19ZAK1.80314785
20BRSK21.77256967
21GRK51.75272622
22MAP3K91.74881227
23STK161.73572600
24MAP4K21.73237631
25BCR1.67765868
26CAMKK21.65977610
27EPHA41.64667921
28TNIK1.62129138
29SRPK11.61064030
30AKT31.55648159
31MINK11.53529865
32GRK71.44794053
33STK391.43847366
34BMPR21.40445009
35BRAF1.39194232
36MAPK131.35217920
37FGFR21.33434992
38ADRBK21.32133001
39MUSK1.25449672
40DAPK11.25249229
41MST41.24382867
42MKNK21.22139557
43MKNK11.21033943
44STK31.20147612
45MAP3K131.16269582
46DYRK31.08940223
47CCNB11.08018930
48PRPF4B1.07039761
49CAMK2A1.04112850
50PRKCG1.01552821
51SIK31.01315873
52CAMK2B1.01096885
53STK38L0.98218592
54NTRK10.98014978
55MAP3K20.96777388
56MYLK0.96530790
57MARK10.93914491
58CSNK1G30.93409926
59BMPR1B0.93266843
60DAPK20.87339558
61MAPKAPK50.85913210
62LIMK10.85146371
63CDK50.84225771
64CSNK1G20.84094217
65FES0.83377562
66PDK40.82542903
67PDK30.82542903
68RPS6KA40.81974762
69PRKCE0.79542489
70SGK2230.75474401
71SGK4940.75474401
72CAMK2D0.74662432
73CAMK2G0.73610586
74NEK10.73393854
75WNK40.73236852
76ADRBK10.72166850
77KSR10.70480950
78KSR20.69945009
79NTRK20.69006396
80VRK10.68177509
81RAF10.67987235
82MAP3K60.67096952
83DYRK20.66609709
84FRK0.64623188
85INSRR0.63949130
86FER0.59154436
87FGR0.58997941
88NEK60.58791395
89BRSK10.58486281
90STK240.57517493
91OBSCN0.57123646
92CDK180.57114630
93CDK140.57041998
94SGK20.56604842
95UHMK10.56556809
96BUB10.56340336
97PTK2B0.55580563
98EIF2AK30.53471878
99CSNK1A1L0.52441448
100PLK30.51970512
101GRK10.51647811
102TEC0.51439802
103MOS0.50385761
104PHKG20.50266991
105PHKG10.50266991
106PKN10.50009324
107CSNK1G10.48575581
108RPS6KA50.47459803
109CDK150.46922158
110PRKACA0.46892292
111PASK0.46816373
112MAP2K10.46083682
113EIF2AK10.45785855
114ERBB40.45196964
115PDK20.44668131
116NLK0.44261484
117PIK3CG0.43031049
118WNK30.43008251
119EPHA30.42829802
120PRKG10.41824671
121TNK20.41065352
122TXK0.40505606
123FGFR30.40145688
124CDK11A0.39247814
125YES10.38851548
126PBK0.38661765
127PLK10.38576249
128CDK80.38410252
129PINK10.38007865
130PLK40.37504185
131DYRK1A0.36868740
132ATR0.36746066
133CSNK1A10.35759927
134PRKCH0.35584349
135PAK60.35556009
136PAK30.35520790
137WEE10.35400894
138TAOK30.35118884
139ROCK20.34975918
140TAF10.34725765
141CDK30.33302983
142BMX0.32973453
143GRK60.32775903
144TTK0.32611347

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002327.70461740
2Oxidative phosphorylation_Homo sapiens_hsa001904.91350815
3Collecting duct acid secretion_Homo sapiens_hsa049664.00306842
4Parkinsons disease_Homo sapiens_hsa050123.81420510
5Synaptic vesicle cycle_Homo sapiens_hsa047213.51969989
6Nicotine addiction_Homo sapiens_hsa050333.36645985
7Alzheimers disease_Homo sapiens_hsa050103.08153416
8Vibrio cholerae infection_Homo sapiens_hsa051102.71685717
9Huntingtons disease_Homo sapiens_hsa050162.57831062
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32297162
11Proteasome_Homo sapiens_hsa030502.27297573
12GABAergic synapse_Homo sapiens_hsa047272.22454739
13Protein export_Homo sapiens_hsa030602.20929262
14Nitrogen metabolism_Homo sapiens_hsa009102.11668664
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08287402
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01182312
17Morphine addiction_Homo sapiens_hsa050321.87997448
18Amphetamine addiction_Homo sapiens_hsa050311.87694608
19Cardiac muscle contraction_Homo sapiens_hsa042601.86861933
20Olfactory transduction_Homo sapiens_hsa047401.80894576
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.77125887
22Long-term potentiation_Homo sapiens_hsa047201.72660848
23Serotonergic synapse_Homo sapiens_hsa047261.64611717
24Circadian entrainment_Homo sapiens_hsa047131.63198836
25Dopaminergic synapse_Homo sapiens_hsa047281.62359302
26Rheumatoid arthritis_Homo sapiens_hsa053231.59187088
27Taste transduction_Homo sapiens_hsa047421.56594273
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53769903
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52392896
30Glutamatergic synapse_Homo sapiens_hsa047241.51841273
31Circadian rhythm_Homo sapiens_hsa047101.51573902
32Fanconi anemia pathway_Homo sapiens_hsa034601.50134705
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44095394
34Insulin secretion_Homo sapiens_hsa049111.31828207
35RNA degradation_Homo sapiens_hsa030181.31266201
36Type I diabetes mellitus_Homo sapiens_hsa049401.26834147
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26457584
38Tryptophan metabolism_Homo sapiens_hsa003801.24010372
39Long-term depression_Homo sapiens_hsa047301.22255915
40Pyruvate metabolism_Homo sapiens_hsa006201.20930686
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19992259
42Mismatch repair_Homo sapiens_hsa034301.18301762
43Peroxisome_Homo sapiens_hsa041461.14674722
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.13583796
45Linoleic acid metabolism_Homo sapiens_hsa005911.13215369
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11099052
47Cocaine addiction_Homo sapiens_hsa050301.10896869
48Steroid biosynthesis_Homo sapiens_hsa001001.10566503
49Phagosome_Homo sapiens_hsa041451.10075745
50Calcium signaling pathway_Homo sapiens_hsa040201.09839862
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08404751
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06276499
53Fatty acid elongation_Homo sapiens_hsa000621.05090414
54Phototransduction_Homo sapiens_hsa047441.04875767
55Renin secretion_Homo sapiens_hsa049241.04584560
56Regulation of autophagy_Homo sapiens_hsa041401.04189801
57Cholinergic synapse_Homo sapiens_hsa047251.02298229
58Salivary secretion_Homo sapiens_hsa049701.01477394
59Selenocompound metabolism_Homo sapiens_hsa004500.97634516
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91563339
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90964492
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89991959
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83940305
64Homologous recombination_Homo sapiens_hsa034400.83700654
65Sulfur metabolism_Homo sapiens_hsa009200.83345150
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83070755
67Gastric acid secretion_Homo sapiens_hsa049710.81731514
68Oxytocin signaling pathway_Homo sapiens_hsa049210.80728494
69Chemical carcinogenesis_Homo sapiens_hsa052040.80343841
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79207812
71Platelet activation_Homo sapiens_hsa046110.78260509
72Butanoate metabolism_Homo sapiens_hsa006500.75893729
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74446969
74RNA polymerase_Homo sapiens_hsa030200.73437836
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73167227
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.72747925
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68467973
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67161894
79Arachidonic acid metabolism_Homo sapiens_hsa005900.66062606
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63426022
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62817921
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62788616
83Systemic lupus erythematosus_Homo sapiens_hsa053220.57902959
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56604129
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55522387
86beta-Alanine metabolism_Homo sapiens_hsa004100.54715034
87Sphingolipid metabolism_Homo sapiens_hsa006000.54531411
88Vitamin B6 metabolism_Homo sapiens_hsa007500.54186019
89Phenylalanine metabolism_Homo sapiens_hsa003600.53639006
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53220197
91Propanoate metabolism_Homo sapiens_hsa006400.50350662
92GnRH signaling pathway_Homo sapiens_hsa049120.49653857
93Gap junction_Homo sapiens_hsa045400.48562668
94Metabolic pathways_Homo sapiens_hsa011000.47059702
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46841088
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45616985
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.45535628
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45132080
99Alcoholism_Homo sapiens_hsa050340.44608262
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44281285
101cAMP signaling pathway_Homo sapiens_hsa040240.44171081
102Nucleotide excision repair_Homo sapiens_hsa034200.43861160
103Oocyte meiosis_Homo sapiens_hsa041140.43327253
104Tyrosine metabolism_Homo sapiens_hsa003500.42821294
105RNA transport_Homo sapiens_hsa030130.40338735
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40021145
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39984385
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39876950
109Cell cycle_Homo sapiens_hsa041100.38428735
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.37832105
111Purine metabolism_Homo sapiens_hsa002300.35791452
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35153263
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34033181
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32643444
115Pyrimidine metabolism_Homo sapiens_hsa002400.32331072
116Fatty acid metabolism_Homo sapiens_hsa012120.31444608
117One carbon pool by folate_Homo sapiens_hsa006700.29848430
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29804982
119African trypanosomiasis_Homo sapiens_hsa051430.27941347
120Pancreatic secretion_Homo sapiens_hsa049720.27735047
121Ether lipid metabolism_Homo sapiens_hsa005650.27208771
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25723814
123ErbB signaling pathway_Homo sapiens_hsa040120.24095491
124Carbon metabolism_Homo sapiens_hsa012000.22653639
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22427762
126Estrogen signaling pathway_Homo sapiens_hsa049150.22047172
127Non-homologous end-joining_Homo sapiens_hsa034500.21574666
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21501568
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19326794
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19195995
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18160032
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17563560
133Thyroid hormone synthesis_Homo sapiens_hsa049180.16200860
134Glucagon signaling pathway_Homo sapiens_hsa049220.15494776
135Inositol phosphate metabolism_Homo sapiens_hsa005620.15474506
136Ras signaling pathway_Homo sapiens_hsa040140.13693403
137Basal transcription factors_Homo sapiens_hsa030220.13428471
138Axon guidance_Homo sapiens_hsa043600.12759597
139Allograft rejection_Homo sapiens_hsa053300.12694815
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.12470684
141Type II diabetes mellitus_Homo sapiens_hsa049300.12437573

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