TTC25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.50638649
2cilium or flagellum-dependent cell motility (GO:0001539)8.02321671
3axonemal dynein complex assembly (GO:0070286)7.22283445
4epithelial cilium movement (GO:0003351)6.66212018
5microtubule bundle formation (GO:0001578)6.39048828
6fusion of sperm to egg plasma membrane (GO:0007342)6.36376432
7motile cilium assembly (GO:0044458)6.34206243
8cilium movement (GO:0003341)6.20801767
9multicellular organism reproduction (GO:0032504)5.96341853
10primary alcohol catabolic process (GO:0034310)5.92499884
11sperm motility (GO:0030317)5.75887772
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.52625725
13cell wall macromolecule catabolic process (GO:0016998)5.45362127
14cell wall macromolecule metabolic process (GO:0044036)5.45362127
15sperm-egg recognition (GO:0035036)5.43162405
16acrosome reaction (GO:0007340)5.42792102
17regulation of microtubule-based movement (GO:0060632)5.39142636
18piRNA metabolic process (GO:0034587)5.35671079
19acrosome assembly (GO:0001675)5.32461907
20vitamin transmembrane transport (GO:0035461)4.94913086
21cell-cell recognition (GO:0009988)4.87173561
22regulation of cilium movement (GO:0003352)4.84430127
23microtubule depolymerization (GO:0007019)4.81435566
24ethanol metabolic process (GO:0006067)4.79630001
25diterpenoid biosynthetic process (GO:0016102)4.76953433
26binding of sperm to zona pellucida (GO:0007339)4.76810508
27microtubule-based movement (GO:0007018)4.70384221
28plasma membrane fusion (GO:0045026)4.67765557
29male meiosis (GO:0007140)4.66825963
30reproduction (GO:0000003)4.55923858
31lung epithelium development (GO:0060428)4.52405277
32centriole assembly (GO:0098534)4.47616565
33DNA methylation involved in gamete generation (GO:0043046)4.47515099
34spermatid development (GO:0007286)4.41386819
35response to xenobiotic stimulus (GO:0009410)4.40017218
36cell projection assembly (GO:0030031)4.27722399
37one-carbon compound transport (GO:0019755)4.22020198
38GTP biosynthetic process (GO:0006183)4.19492331
39centriole replication (GO:0007099)4.05884386
40synaptonemal complex organization (GO:0070193)4.04293524
41single fertilization (GO:0007338)4.03292415
42synaptonemal complex assembly (GO:0007130)3.92600634
43male meiosis I (GO:0007141)3.87290700
44pyrimidine-containing compound transmembrane transport (GO:0072531)3.86960723
45establishment or maintenance of monopolar cell polarity (GO:0061339)3.76395138
46establishment of monopolar cell polarity (GO:0061162)3.76395138
47negative regulation of T cell differentiation in thymus (GO:0033085)3.67859283
48cytoplasmic microtubule organization (GO:0031122)3.66560314
49retinoic acid metabolic process (GO:0042573)3.64490605
50tolerance induction (GO:0002507)3.64267340
51negative regulation of immunoglobulin mediated immune response (GO:0002890)3.63957848
52negative regulation of B cell mediated immunity (GO:0002713)3.63957848
53determination of left/right symmetry (GO:0007368)3.62170048
54ventricular system development (GO:0021591)3.60923858
55chromosome organization involved in meiosis (GO:0070192)3.58047555
56DNA deamination (GO:0045006)3.57868590
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.56411461
58terpenoid biosynthetic process (GO:0016114)3.55315037
59ethanol oxidation (GO:0006069)3.53047817
60smoothened signaling pathway (GO:0007224)3.48139718
61axoneme assembly (GO:0035082)3.47565622
62base-excision repair, AP site formation (GO:0006285)3.46365544
63determination of bilateral symmetry (GO:0009855)3.45109227
64UTP biosynthetic process (GO:0006228)3.43421985
65establishment of apical/basal cell polarity (GO:0035089)3.42957091
66lateral sprouting from an epithelium (GO:0060601)3.42226102
67deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.41929494
68establishment of tissue polarity (GO:0007164)3.37319794
69establishment of planar polarity (GO:0001736)3.37319794
70nonmotile primary cilium assembly (GO:0035058)3.36253542
71specification of symmetry (GO:0009799)3.36139447
72nucleoside diphosphate phosphorylation (GO:0006165)3.36036870
73intraciliary transport (GO:0042073)3.35718720
74lateral ventricle development (GO:0021670)3.35227263
75regulation of interleukin-5 production (GO:0032674)3.34335209
76fertilization (GO:0009566)3.29430130
77synapsis (GO:0007129)3.28321809
78meiosis I (GO:0007127)3.23988339
79protein localization to cilium (GO:0061512)3.22476836
80glomerular epithelial cell development (GO:0072310)3.21481429
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.19526931
82termination of RNA polymerase III transcription (GO:0006386)3.19526931
83spermatogenesis (GO:0007283)3.18463629
84male gamete generation (GO:0048232)3.18278977
85microtubule polymerization or depolymerization (GO:0031109)3.16309658
86exogenous drug catabolic process (GO:0042738)3.15505578
87meiotic nuclear division (GO:0007126)3.14960149
88cilium assembly (GO:0042384)3.14235998
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.13857410
90cilium organization (GO:0044782)3.13616423
91spermatid nucleus differentiation (GO:0007289)3.09091618
92pyrimidine nucleotide catabolic process (GO:0006244)3.07952871
93guanosine-containing compound biosynthetic process (GO:1901070)3.07403634
94negative regulation of humoral immune response (GO:0002921)3.05819503
95positive regulation of smoothened signaling pathway (GO:0045880)3.05470981
96sperm capacitation (GO:0048240)3.05310651
97retinal rod cell development (GO:0046548)3.04612152
98RNA destabilization (GO:0050779)3.02886641
99protein polyglutamylation (GO:0018095)3.01672614
100meiotic cell cycle (GO:0051321)2.99620113
101regulation of germinal center formation (GO:0002634)2.98028885
102aldehyde catabolic process (GO:0046185)2.97956365
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97270652
104gamete generation (GO:0007276)2.97004514
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.96870901
106pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93475802
107negative regulation of inclusion body assembly (GO:0090084)2.93439401
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92279051
109regulation of mitotic spindle checkpoint (GO:1903504)2.92279051
110left/right axis specification (GO:0070986)2.91323535
111regulation of spindle checkpoint (GO:0090231)2.90753979
112single strand break repair (GO:0000012)2.90388633
113histone exchange (GO:0043486)2.89459364
114apical protein localization (GO:0045176)2.89343315
115proteasome assembly (GO:0043248)2.88447618
116microtubule-based process (GO:0007017)2.87261625
117regulation of interleukin-13 production (GO:0032656)2.86965164
118retinol metabolic process (GO:0042572)2.85310142
119heart looping (GO:0001947)2.84136596
120kinetochore assembly (GO:0051382)2.82703174
121chromatin remodeling at centromere (GO:0031055)2.78681103
122CTP metabolic process (GO:0046036)2.76253450
123CTP biosynthetic process (GO:0006241)2.76253450
124organelle assembly (GO:0070925)2.75009258
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.74726256
126CENP-A containing nucleosome assembly (GO:0034080)2.70332708
127deoxyribonucleotide biosynthetic process (GO:0009263)2.70162130
128positive regulation of tolerance induction (GO:0002645)2.69406346
129regulation of double-strand break repair via homologous recombination (GO:0010569)2.68881633
130UTP metabolic process (GO:0046051)2.66962152
131drug catabolic process (GO:0042737)2.66455853
132primary alcohol metabolic process (GO:0034308)2.65727950
1337-methylguanosine mRNA capping (GO:0006370)2.65011074
1347-methylguanosine RNA capping (GO:0009452)2.64267685
135RNA capping (GO:0036260)2.64267685
136kinetochore organization (GO:0051383)2.63576653
137DNA double-strand break processing (GO:0000729)2.63122784
138hydrogen peroxide biosynthetic process (GO:0050665)2.63048542
139cilium morphogenesis (GO:0060271)2.62743336
140regulation of microtubule depolymerization (GO:0031114)2.61377961
141germ cell development (GO:0007281)2.61029038
142limb development (GO:0060173)2.60232048
143appendage development (GO:0048736)2.60232048
144regulation of centriole replication (GO:0046599)2.60226046
145superoxide anion generation (GO:0042554)2.59708993
146embryonic heart tube morphogenesis (GO:0003143)2.59457746
147protein K6-linked ubiquitination (GO:0085020)2.58086494
148meiotic chromosome segregation (GO:0045132)2.57649383
149regulation of collateral sprouting (GO:0048670)2.55181254
150glutathione derivative biosynthetic process (GO:1901687)2.54345070
151glutathione derivative metabolic process (GO:1901685)2.54345070
152cellular component assembly involved in morphogenesis (GO:0010927)2.54138408
153regulation of meiosis I (GO:0060631)2.53008233
154rRNA modification (GO:0000154)2.52978182
155meiotic cell cycle process (GO:1903046)2.52802677
156photoreceptor cell maintenance (GO:0045494)2.52776893
157negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.52773262
158embryonic camera-type eye development (GO:0031076)2.51221879
159cellular process involved in reproduction in multicellular organism (GO:0022412)2.51184078
160telomere maintenance via semi-conservative replication (GO:0032201)2.48323553
161telomere maintenance via recombination (GO:0000722)2.47825446
162termination of RNA polymerase I transcription (GO:0006363)2.47619625
163pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.47108185
164DNA-dependent DNA replication (GO:0006261)2.46913241
165cornea development in camera-type eye (GO:0061303)2.45008392
166asymmetric protein localization (GO:0008105)2.44292639
167cell recognition (GO:0008037)2.44038426
168regulation of smoothened signaling pathway (GO:0008589)2.43513449
169O-glycan processing (GO:0016266)2.41738644
170transcription elongation from RNA polymerase I promoter (GO:0006362)2.41373292
171reactive oxygen species biosynthetic process (GO:1903409)2.38190837
172regulation of autophagic vacuole assembly (GO:2000785)2.35610199
173hydrogen peroxide catabolic process (GO:0042744)2.35269549
174spinal cord motor neuron differentiation (GO:0021522)2.30070672
175carnitine metabolic process (GO:0009437)2.28869823
176phenol-containing compound catabolic process (GO:0019336)2.25370095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.10601373
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.47134533
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.18724419
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.98549491
5EZH2_22144423_ChIP-Seq_EOC_Human3.38518256
6DROSHA_22980978_ChIP-Seq_HELA_Human2.94132495
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.86392666
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.78539915
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76590080
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.57871086
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48680343
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32627788
13VDR_22108803_ChIP-Seq_LS180_Human2.29958588
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26524299
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19569610
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15800979
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.12834704
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.09917123
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04987333
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99706517
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88270816
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.83152334
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82935993
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.81757115
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81234856
26KAP1_22055183_ChIP-Seq_ESCs_Mouse1.79609486
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.72103564
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70949552
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.70586777
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69534304
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69381153
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68159625
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66976194
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.63982737
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63703842
36AHR_22903824_ChIP-Seq_MCF-7_Human1.62756678
37EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.59917703
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59733475
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59678047
40E2F7_22180533_ChIP-Seq_HELA_Human1.59378410
41STAT3_18555785_Chip-Seq_ESCs_Mouse1.58936003
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58865985
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58638676
44GBX2_23144817_ChIP-Seq_PC3_Human1.57260082
45RNF2_27304074_Chip-Seq_NSC_Mouse1.56705583
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.56536581
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54410980
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.54153159
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53886103
50P53_22387025_ChIP-Seq_ESCs_Mouse1.52333017
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52179866
52P300_18555785_Chip-Seq_ESCs_Mouse1.51135677
53FUS_26573619_Chip-Seq_HEK293_Human1.49659099
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.48784122
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.48556303
56RUNX1_27457419_Chip-Seq_LIVER_Mouse1.47988306
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.46894217
58NMYC_18555785_Chip-Seq_ESCs_Mouse1.45436283
59KLF4_18555785_Chip-Seq_ESCs_Mouse1.44954307
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43220448
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42981035
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.42392059
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42004159
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.41453093
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.40804215
66SMAD4_21799915_ChIP-Seq_A2780_Human1.40261724
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.39932200
68TAF15_26573619_Chip-Seq_HEK293_Human1.35854863
69ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35725634
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34018920
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.33431563
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32978853
73* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32494520
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32313099
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32266275
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32041042
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.31163530
78SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31049546
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.30119426
80PU1_27457419_Chip-Seq_LIVER_Mouse1.29911861
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.29629897
82REST_21632747_ChIP-Seq_MESCs_Mouse1.28409374
83AR_21572438_ChIP-Seq_LNCaP_Human1.27811636
84TP53_18474530_ChIP-ChIP_U2OS_Human1.27635148
85SMC4_20622854_ChIP-Seq_HELA_Human1.27296699
86TP63_23658742_ChIP-Seq_EP156T_Human1.26608888
87ETV1_20927104_ChIP-Seq_GIST48_Human1.25659489
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.25380834
89TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25193018
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.25165275
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23633531
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23339095
93ER_23166858_ChIP-Seq_MCF-7_Human1.23293577
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21807847
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21352658
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21015090
97IRF1_19129219_ChIP-ChIP_H3396_Human1.19756227
98FOXA1_25552417_ChIP-Seq_VCAP_Human1.18413665
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17689581
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.17679764
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17336342
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17276946
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.17248377
104PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15591641
105STAT1_17558387_ChIP-Seq_HELA_Human1.15524477
106WDR5_24793694_ChIP-Seq_LNCAP_Human1.14485064
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14127679
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13103635
109CTCF_27219007_Chip-Seq_Bcells_Human1.12863128
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12563815
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12062766
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11861269
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.11280574
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.10575768
115* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10227527
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10017350
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09980394
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09815339
119HNFA_21074721_ChIP-Seq_CACO-2_Human1.09450963
120STAT1_20625510_ChIP-Seq_HELA_Human1.09212535
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07906696
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07810964
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07787875
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.07361011
125EZH2_27304074_Chip-Seq_ESCs_Mouse1.07154062
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06684616
127SMRT_27268052_Chip-Seq_Bcells_Human1.06677203
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06219612
129CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04302322
130CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03687702
131KLF5_25053715_ChIP-Seq_YYC3_Human1.03613841
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03441272
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03388555
134TBL1_22424771_ChIP-Seq_293T_Human1.03361302
135STAT3_23295773_ChIP-Seq_U87_Human1.02468421
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02094450
137BCAT_22108803_ChIP-Seq_LS180_Human1.01819846
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.01657446
139RBPJ_21746931_ChIP-Seq_IB4_Human1.01472040
140NFYA_21822215_ChIP-Seq_K562_Human1.01467919
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01391967
142VDR_23849224_ChIP-Seq_CD4+_Human1.01347200
143TCF4_22108803_ChIP-Seq_LS180_Human1.01245582
144TP63_22573176_ChIP-Seq_HFKS_Human1.01046897
145CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00971234
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99829412
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99829412
148TP53_16413492_ChIP-PET_HCT116_Human0.98617807
149TCF4_23295773_ChIP-Seq_U87_Human0.97942912
150P300_19829295_ChIP-Seq_ESCs_Human0.97084212
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97079928
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97078141
153IGF1R_20145208_ChIP-Seq_DFB_Human0.96952366
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96720399
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96510331
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.96022421
157NFYB_21822215_ChIP-Seq_K562_Human0.94839430
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94828097
159ZNF274_21170338_ChIP-Seq_K562_Hela0.94589951
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.94240661
161FOXA1_25329375_ChIP-Seq_VCAP_Human0.94195529
162FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94195529
163JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93799195
164LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93706780
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93587971
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92412260
167NOTCH1_21737748_ChIP-Seq_TLL_Human0.91872663
168EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91683613
169SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91641851
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91636327
171KDM2B_26808549_Chip-Seq_REH_Human0.91362042
172ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91006606
173IRF8_21731497_ChIP-ChIP_J774_Mouse0.90625538
174GATA3_21867929_ChIP-Seq_CD8_Mouse0.88541921
175PHF8_20622853_ChIP-Seq_HELA_Human0.88129337
176FOXP3_21729870_ChIP-Seq_TREG_Human0.87150379
177* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86572379
178HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85646959
179CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85610127
180* GATA3_21867929_ChIP-Seq_TH1_Mouse0.84964929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.38438981
2MP0008875_abnormal_xenobiotic_pharmacok4.85642793
3MP0009780_abnormal_chondrocyte_physiolo3.48082431
4MP0008877_abnormal_DNA_methylation3.37711412
5MP0001188_hyperpigmentation3.14426955
6MP0003136_yellow_coat_color3.13780729
7MP0006292_abnormal_olfactory_placode3.03701920
8MP0003698_abnormal_male_reproductive2.85503884
9MP0008058_abnormal_DNA_repair2.76009909
10MP0001929_abnormal_gametogenesis2.66478840
11MP0000566_synostosis2.66198306
12MP0004043_abnormal_pH_regulation2.65635334
13MP0008057_abnormal_DNA_replication2.45844574
14MP0002102_abnormal_ear_morphology2.40080850
15MP0005623_abnormal_meninges_morphology2.30097504
16MP0002210_abnormal_sex_determination2.27933660
17MP0001986_abnormal_taste_sensitivity2.24788554
18MP0004381_abnormal_hair_follicle2.19026405
19MP0002277_abnormal_respiratory_mucosa2.11329283
20MP0000383_abnormal_hair_follicle2.03255516
21MP0005171_absent_coat_pigmentation2.02677270
22MP0002160_abnormal_reproductive_system1.94961204
23MP0003111_abnormal_nucleus_morphology1.92363554
24MP0002928_abnormal_bile_duct1.90249656
25MP0010094_abnormal_chromosome_stability1.86953193
26MP0002282_abnormal_trachea_morphology1.85794631
27MP0003693_abnormal_embryo_hatching1.84017371
28MP0010030_abnormal_orbit_morphology1.83154725
29MP0001145_abnormal_male_reproductive1.77217041
30MP0003786_premature_aging1.74184673
31MP0008995_early_reproductive_senescence1.71236579
32MP0005083_abnormal_biliary_tract1.70329347
33MP0003941_abnormal_skin_development1.67194915
34MP0000015_abnormal_ear_pigmentation1.65518154
35MP0002653_abnormal_ependyma_morphology1.62488738
36MP0001984_abnormal_olfaction1.61812164
37MP0002638_abnormal_pupillary_reflex1.61764124
38MP0002132_abnormal_respiratory_system1.61269452
39MP0005423_abnormal_somatic_nervous1.60803999
40MP0003718_maternal_effect1.59813496
41MP0000653_abnormal_sex_gland1.57691579
42MP0004742_abnormal_vestibular_system1.55902325
43MP0004019_abnormal_vitamin_homeostasis1.54897393
44MP0010678_abnormal_skin_adnexa1.52845811
45MP0005409_darkened_coat_color1.48101028
46MP0005174_abnormal_tail_pigmentation1.47094272
47MP0002734_abnormal_mechanical_nocicepti1.44859576
48MP0005075_abnormal_melanosome_morpholog1.43905416
49MP0002161_abnormal_fertility/fecundity1.42547042
50MP0008932_abnormal_embryonic_tissue1.38175372
51MP0005645_abnormal_hypothalamus_physiol1.38008195
52MP0002909_abnormal_adrenal_gland1.37809038
53MP0002233_abnormal_nose_morphology1.37683655
54MP0002163_abnormal_gland_morphology1.35583630
55MP0005389_reproductive_system_phenotype1.33307369
56MP0000372_irregular_coat_pigmentation1.31073568
57MP0002249_abnormal_larynx_morphology1.29979167
58MP0008007_abnormal_cellular_replicative1.27612693
59MP0005248_abnormal_Harderian_gland1.26328361
60MP0003656_abnormal_erythrocyte_physiolo1.24427359
61MP0005379_endocrine/exocrine_gland_phen1.22399148
62MP0002735_abnormal_chemical_nociception1.21474921
63MP0005646_abnormal_pituitary_gland1.19031894
64MP0004885_abnormal_endolymph1.18773002
65MP0000778_abnormal_nervous_system1.17104072
66MP0000026_abnormal_inner_ear1.13853886
67MP0001765_abnormal_ion_homeostasis1.12925473
68MP0008789_abnormal_olfactory_epithelium1.10685384
69MP0003077_abnormal_cell_cycle1.10540056
70MP0001346_abnormal_lacrimal_gland1.09883150
71MP0000955_abnormal_spinal_cord1.09292827
72MP0004133_heterotaxia1.09171075
73MP0005551_abnormal_eye_electrophysiolog1.09023899
74MP0000678_abnormal_parathyroid_gland1.08796768
75MP0009697_abnormal_copulation1.07254170
76MP0003880_abnormal_central_pattern1.06660588
77MP0002557_abnormal_social/conspecific_i1.05877798
78MP0003315_abnormal_perineum_morphology1.04616201
79MP0006276_abnormal_autonomic_nervous1.04182639
80MP0002168_other_aberrant_phenotype1.03786347
81MP0003861_abnormal_nervous_system1.00898584
82MP0000631_abnormal_neuroendocrine_gland1.00787057
83MP0002148_abnormal_hypersensitivity_rea0.99511435
84MP0003938_abnormal_ear_development0.98622235
85MP0005636_abnormal_mineral_homeostasis0.97559656
86MP0005253_abnormal_eye_physiology0.96763945
87MP0001970_abnormal_pain_threshold0.95407297
88MP0002938_white_spotting0.95265246
89MP0010386_abnormal_urinary_bladder0.94971891
90MP0008260_abnormal_autophagy0.93181000
91MP0009745_abnormal_behavioral_response0.92792747
92MP0009785_altered_susceptibility_to0.91892967
93MP0001963_abnormal_hearing_physiology0.91772109
94MP0005195_abnormal_posterior_eye0.91327130
95MP0003937_abnormal_limbs/digits/tail_de0.91324295
96MP0002876_abnormal_thyroid_physiology0.91076727
97MP0005503_abnormal_tendon_morphology0.90618802
98MP0006072_abnormal_retinal_apoptosis0.90048057
99MP0001299_abnormal_eye_distance/0.88923709
100MP0001486_abnormal_startle_reflex0.88466371
101MP0009046_muscle_twitch0.88451741
102MP0004142_abnormal_muscle_tone0.88383364
103MP0005670_abnormal_white_adipose0.87919866
104MP0002095_abnormal_skin_pigmentation0.87741247
105MP0003787_abnormal_imprinting0.86853870
106MP0002882_abnormal_neuron_morphology0.85790329
107MP0001119_abnormal_female_reproductive0.85408785
108MP0001529_abnormal_vocalization0.85145701
109MP0003878_abnormal_ear_physiology0.84857493
110MP0005377_hearing/vestibular/ear_phenot0.84857493
111MP0000613_abnormal_salivary_gland0.84798182
112MP0001485_abnormal_pinna_reflex0.84387447
113MP0002572_abnormal_emotion/affect_behav0.84033581
114MP0009053_abnormal_anal_canal0.83380093
115MP0009379_abnormal_foot_pigmentation0.83335986
116MP0001835_abnormal_antigen_presentation0.82816911
117MP0000049_abnormal_middle_ear0.82703658
118MP0005395_other_phenotype0.82354565
119MP0001186_pigmentation_phenotype0.82258968
120MP0003942_abnormal_urinary_system0.82206467
121MP0001919_abnormal_reproductive_system0.82140366
122MP0002116_abnormal_craniofacial_bone0.80282283
123MP0003011_delayed_dark_adaptation0.79874732
124MP0005394_taste/olfaction_phenotype0.79480138
125MP0005499_abnormal_olfactory_system0.79480138
126MP0001944_abnormal_pancreas_morphology0.79039237
127MP0003122_maternal_imprinting0.78465643
128MP0001324_abnormal_eye_pigmentation0.78243862
129MP0002272_abnormal_nervous_system0.77744186
130MP0002152_abnormal_brain_morphology0.75179239
131MP0005085_abnormal_gallbladder_physiolo0.75014587
132MP0001270_distended_abdomen0.73719023
133MP0002752_abnormal_somatic_nervous0.73556097
134MP0005084_abnormal_gallbladder_morpholo0.73552163
135MP0003890_abnormal_embryonic-extraembry0.73514904
136MP0002751_abnormal_autonomic_nervous0.73318796
137MP0005408_hypopigmentation0.72507507
138MP0001502_abnormal_circadian_rhythm0.69066061
139MP0003950_abnormal_plasma_membrane0.68961084
140MP0001293_anophthalmia0.67881182
141MP0001905_abnormal_dopamine_level0.67829882
142MP0002092_abnormal_eye_morphology0.66982354
143MP0002229_neurodegeneration0.65146411
144MP0002822_catalepsy0.64668805
145MP0003252_abnormal_bile_duct0.64408634
146MP0005671_abnormal_response_to0.62385549
147MP0001853_heart_inflammation0.62255123
148MP0002067_abnormal_sensory_capabilities0.62185046
149MP0004782_abnormal_surfactant_physiolog0.61859562
150MP0002736_abnormal_nociception_after0.60935679
151MP0004859_abnormal_synaptic_plasticity0.59734411
152MP0002075_abnormal_coat/hair_pigmentati0.59432103
153MP0005391_vision/eye_phenotype0.58810111
154MP0001727_abnormal_embryo_implantation0.58549951
155MP0004957_abnormal_blastocyst_morpholog0.58517745
156MP0003724_increased_susceptibility_to0.58453512
157MP0002419_abnormal_innate_immunity0.57137743
158MP0004270_analgesia0.55529336

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.20959753
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.61321689
3Absent/shortened dynein arms (HP:0200106)7.61321689
4Abnormal respiratory epithelium morphology (HP:0012253)6.45533263
5Abnormal respiratory motile cilium morphology (HP:0005938)6.45533263
6Abnormal respiratory motile cilium physiology (HP:0012261)6.39329805
7Abnormal ciliary motility (HP:0012262)5.98628317
8Rhinitis (HP:0012384)4.98786351
9Abnormality of the nasal mucosa (HP:0000433)4.86304791
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.32946779
11Chronic bronchitis (HP:0004469)3.94089359
12Chromsome breakage (HP:0040012)3.88823502
13Occipital encephalocele (HP:0002085)3.51458609
14Male infertility (HP:0003251)3.35593870
15Atelectasis (HP:0100750)3.32199727
16Nephronophthisis (HP:0000090)3.21097681
17Medial flaring of the eyebrow (HP:0010747)3.08201765
18Bronchiectasis (HP:0002110)3.04420906
19Cystic liver disease (HP:0006706)2.97059804
20Duplicated collecting system (HP:0000081)2.91061902
21True hermaphroditism (HP:0010459)2.71128788
22Pancreatic fibrosis (HP:0100732)2.68856801
23Abnormal spermatogenesis (HP:0008669)2.59993951
24Abnormality of the renal medulla (HP:0100957)2.59559817
25Chronic otitis media (HP:0000389)2.55813914
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.52420407
27Abnormality of the renal collecting system (HP:0004742)2.52012395
28Infertility (HP:0000789)2.51179781
29Meckel diverticulum (HP:0002245)2.51016451
30Pancreatic cysts (HP:0001737)2.49776333
31Abnormality of midbrain morphology (HP:0002418)2.45672548
32Molar tooth sign on MRI (HP:0002419)2.45672548
33Recurrent sinusitis (HP:0011108)2.44614581
34Hyperactive renin-angiotensin system (HP:0000841)2.43239344
35Abnormality of the preputium (HP:0100587)2.42835132
36Congenital primary aphakia (HP:0007707)2.39377519
37Tubulointerstitial nephritis (HP:0001970)2.39224032
38Abnormality of the ileum (HP:0001549)2.38931606
39Gait imbalance (HP:0002141)2.34163261
40Nephrogenic diabetes insipidus (HP:0009806)2.32744040
41Abnormality of chromosome stability (HP:0003220)2.32120168
42Supernumerary spleens (HP:0009799)2.27651010
43Azoospermia (HP:0000027)2.24589496
44Bronchitis (HP:0012387)2.19198750
45Impulsivity (HP:0100710)2.18873737
46Median cleft lip (HP:0000161)2.17399611
47Clubbing of toes (HP:0100760)2.17370599
48Nasal polyposis (HP:0100582)2.11931256
49Postaxial foot polydactyly (HP:0001830)2.10310519
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09402846
51Prostate neoplasm (HP:0100787)2.04830027
52Decreased central vision (HP:0007663)2.01251984
53Ectopic kidney (HP:0000086)2.01178231
54Preaxial hand polydactyly (HP:0001177)2.00646295
55Attenuation of retinal blood vessels (HP:0007843)1.98376586
56Postaxial hand polydactyly (HP:0001162)1.97717975
57Septo-optic dysplasia (HP:0100842)1.97328347
58Optic nerve hypoplasia (HP:0000609)1.96402937
59Severe visual impairment (HP:0001141)1.95902140
60Congenital hepatic fibrosis (HP:0002612)1.92964137
61Facial cleft (HP:0002006)1.92881665
62Type I transferrin isoform profile (HP:0003642)1.92859829
63Triphalangeal thumb (HP:0001199)1.92757177
64Birth length less than 3rd percentile (HP:0003561)1.91920301
65Aganglionic megacolon (HP:0002251)1.90811641
66Sclerocornea (HP:0000647)1.90147003
67Male pseudohermaphroditism (HP:0000037)1.88879758
68Poor coordination (HP:0002370)1.88484661
69Aplasia/Hypoplasia of the lens (HP:0008063)1.86378737
70Tubular atrophy (HP:0000092)1.86132595
71Aplasia/Hypoplasia of the spleen (HP:0010451)1.85728886
72Type 2 muscle fiber atrophy (HP:0003554)1.85626821
733-Methylglutaconic aciduria (HP:0003535)1.85226913
74Reticulocytopenia (HP:0001896)1.84593416
75Progressive external ophthalmoplegia (HP:0000590)1.82927398
76Nephroblastoma (Wilms tumor) (HP:0002667)1.82101923
77Asplenia (HP:0001746)1.81807431
78Retrobulbar optic neuritis (HP:0100654)1.80631794
79Optic neuritis (HP:0100653)1.80631794
80Microvesicular hepatic steatosis (HP:0001414)1.80502056
81Dyschromatopsia (HP:0007641)1.79403790
82Abnormality of renal resorption (HP:0011038)1.79211417
83Bell-shaped thorax (HP:0001591)1.78508842
84Furrowed tongue (HP:0000221)1.78455395
85Decreased circulating renin level (HP:0003351)1.77187134
86Oculomotor apraxia (HP:0000657)1.76704242
87Vaginal atresia (HP:0000148)1.76092459
88Parakeratosis (HP:0001036)1.75718662
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.75368693
90Absent radius (HP:0003974)1.75259060
91Genital tract atresia (HP:0001827)1.74914259
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73869984
93Duodenal stenosis (HP:0100867)1.73431367
94Small intestinal stenosis (HP:0012848)1.73431367
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73267169
96Abnormality of molar (HP:0011077)1.70340307
97Abnormality of molar morphology (HP:0011070)1.70340307
98Recurrent otitis media (HP:0000403)1.68728611
99Nephropathy (HP:0000112)1.68546966
100Embryonal renal neoplasm (HP:0011794)1.67941321
101Cleft eyelid (HP:0000625)1.67777400
102Aplasia involving forearm bones (HP:0009822)1.67284997
103Absent forearm bone (HP:0003953)1.67284997
104Anencephaly (HP:0002323)1.66918851
105Renal dysplasia (HP:0000110)1.66895081
106Astigmatism (HP:0000483)1.66790984
107Absent thumb (HP:0009777)1.65706543
108Abnormality of the dental root (HP:0006486)1.65067898
109Taurodontia (HP:0000679)1.65067898
110Abnormality of permanent molar morphology (HP:0011071)1.65067898
111Abnormal hair whorl (HP:0010721)1.64202113
112Breast hypoplasia (HP:0003187)1.64128243
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.63721454
114Bone marrow hypocellularity (HP:0005528)1.61703417
115Chronic sinusitis (HP:0011109)1.59905134
116Chronic hepatic failure (HP:0100626)1.59801240
117Stomach cancer (HP:0012126)1.59350071
118Renal salt wasting (HP:0000127)1.58220032
119Fetal akinesia sequence (HP:0001989)1.57837566
120Hyperkalemia (HP:0002153)1.42840027
121Hip dysplasia (HP:0001385)1.41707542
122Absent frontal sinuses (HP:0002688)1.37094727
123Recurrent bronchitis (HP:0002837)1.36775094
124Tubulointerstitial abnormality (HP:0001969)1.36563410
125Abnormal drinking behavior (HP:0030082)1.36460531
126Polydipsia (HP:0001959)1.36460531
127Stage 5 chronic kidney disease (HP:0003774)1.34994230
128Limb-girdle muscle atrophy (HP:0003797)1.33266912
129Hyperaldosteronism (HP:0000859)1.33017618
130Short thorax (HP:0010306)1.30798744
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.29375578
132Sleep apnea (HP:0010535)1.27711997
133Aplasia of the musculature (HP:0100854)1.23038728
134Broad distal phalanx of finger (HP:0009836)1.22794088
135Abnormality of renin-angiotensin system (HP:0000847)1.22533313
136Retinitis pigmentosa (HP:0000510)1.20161193
137Bile duct proliferation (HP:0001408)1.19115124
138Abnormal biliary tract physiology (HP:0012439)1.19115124
139Short femoral neck (HP:0100864)1.18681540
140Bifid scrotum (HP:0000048)1.18103107
141Narrow forehead (HP:0000341)1.16884214
142Abnormality of the dental pulp (HP:0006479)1.16498137
143Abnormality of the middle phalanges of the toes (HP:0010183)1.15013454
144Abnormal rod and cone electroretinograms (HP:0008323)1.14964591
145Abnormality of the renal cortex (HP:0011035)1.13644714
146Abnormality of dentin (HP:0010299)1.11464232
147Hand muscle atrophy (HP:0009130)1.11197444
148Abnormality of chloride homeostasis (HP:0011422)1.10134876
149Prominent nasal bridge (HP:0000426)1.09350961
150Holoprosencephaly (HP:0001360)1.09174980
151Multicystic kidney dysplasia (HP:0000003)1.06503836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.39286540
2PLK43.58662265
3STK163.29002718
4IRAK43.06144373
5ZAK2.89066753
6IRAK12.62081469
7IRAK22.52388133
8BUB12.39911826
9PDK42.39280499
10PDK32.39280499
11CASK2.34547626
12SRPK12.32986757
13PDK22.06511198
14PNCK2.03788300
15PBK1.89993995
16STK241.89717416
17MKNK21.74605932
18MAP3K21.73235286
19VRK11.73223606
20EIF2AK11.70236296
21BMPR1B1.62428553
22EIF2AK21.61736343
23CAMKK21.60151188
24WEE11.53129871
25EIF2AK31.51050654
26TXK1.47476498
27TESK11.45705280
28PTK2B1.43226255
29NEK61.42873133
30TTK1.38869591
31TNIK1.37059198
32TLK11.31296254
33MAPKAPK31.27227398
34YES11.26534445
35MKNK11.22854127
36GRK11.21321935
37MARK11.21209877
38AKT31.18638767
39MAP3K121.18013898
40STK38L1.15362260
41STK391.14953004
42CAMKK11.09039637
43ADRBK21.08461878
44MAP3K71.08247558
45CDK31.07993924
46MAPK151.07889293
47MAP2K71.05680006
48MAP3K141.05447531
49MAP3K41.04933878
50ICK1.04509944
51CDC71.02968775
52BMPR21.02320798
53CHEK21.01013469
54WNK31.00375529
55PINK10.96546183
56FRK0.95737154
57LRRK20.95336848
58BLK0.94192176
59ATR0.92645234
60PLK10.92634032
61MARK20.86599632
62SMG10.85140533
63MST40.83670678
64ERBB20.82647642
65EPHA20.82182549
66GRK70.80228797
67MAP2K40.77327106
68CLK10.76083513
69EPHB10.74049079
70PLK30.72948461
71PKN10.72265666
72DYRK30.71933852
73CSK0.71719595
74MUSK0.69866167
75NTRK30.69206280
76BRAF0.69128740
77NLK0.63955900
78DYRK1B0.63950328
79MAPK130.61581144
80BRSK20.60783822
81DYRK20.58151204
82WNK40.57935067
83RPS6KA50.57452843
84CCNB10.56314273
85PAK30.55790882
86RIPK40.55644697
87ACVR1B0.55594525
88ATM0.54670662
89EPHA40.54618656
90PRPF4B0.53220678
91MINK10.53148791
92AURKA0.51429126
93BRSK10.51197288
94NEK20.51139345
95CHEK10.50865874
96DYRK1A0.50766738
97SIK30.50580051
98TRPM70.50523290
99MAP3K30.50221050
100IKBKB0.49723154
101CSNK2A10.48430266
102INSRR0.48371550
103SGK10.47231043
104BCR0.46723024
105PRKAA20.46565126
106SGK4940.46416100
107SGK2230.46416100
108CDK80.46260210
109PLK20.44857013
110CDK70.43886776
111BRD40.43123508
112STK40.42717839
113AURKB0.42298860
114TSSK60.42071939
115CDK120.41879984
116CAMK2G0.40092277
117FGFR20.40071925
118NUAK10.39576541
119TEC0.39537123
120PRKCG0.39439485
121PRKACA0.39408891
122EEF2K0.38807483
123ADRBK10.37508337
124PRKCD0.37016587
125CAMK1G0.36870751
126NME20.36057431
127NME10.35982839
128MAPK70.35679944
129STK110.35599246
130IKBKE0.34956564
131MAP4K20.34932447
132STK100.34025671
133PRKCQ0.33758986
134PRKD30.33453137
135CDK90.32789220
136EPHA30.32647763
137LYN0.31668511
138PIM20.31321205
139PRKCI0.30964754
140PRKCE0.29762523
141PRKAA10.29091750
142CAMK2A0.28475528
143EPHB20.27762566
144CAMK10.27524684
145MAPKAPK50.27085866
146PASK0.27083422
147MARK30.26954626
148CSNK2A20.25680016
149STK380.24323190
150PRKCZ0.24314511
151TNK20.24167800
152PRKCA0.24012469
153CAMK2B0.23498432
154ERBB30.23366903
155SGK20.23275876
156RPS6KA20.23269606
157CSNK1E0.22565617
158OXSR10.22365135
159HIPK20.20894641

Predicted pathways (KEGG)

RankGene SetZ-score
1Chemical carcinogenesis_Homo sapiens_hsa052044.03841124
2Phenylalanine metabolism_Homo sapiens_hsa003603.93627735
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.77697823
4Fanconi anemia pathway_Homo sapiens_hsa034603.75337195
5Histidine metabolism_Homo sapiens_hsa003403.56622535
6Homologous recombination_Homo sapiens_hsa034403.31834652
7RNA polymerase_Homo sapiens_hsa030203.06697870
8Tyrosine metabolism_Homo sapiens_hsa003503.06145635
9Basal transcription factors_Homo sapiens_hsa030222.98932447
10DNA replication_Homo sapiens_hsa030302.77782659
11beta-Alanine metabolism_Homo sapiens_hsa004102.69446428
12Proteasome_Homo sapiens_hsa030502.67582884
13Caffeine metabolism_Homo sapiens_hsa002322.39016083
14Mismatch repair_Homo sapiens_hsa034302.38286873
15Ribosome_Homo sapiens_hsa030102.28791965
16Pyrimidine metabolism_Homo sapiens_hsa002402.25470231
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23068316
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.16639485
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09098484
20Huntingtons disease_Homo sapiens_hsa050161.92316430
21Nucleotide excision repair_Homo sapiens_hsa034201.91068311
22Spliceosome_Homo sapiens_hsa030401.90568743
23Vitamin B6 metabolism_Homo sapiens_hsa007501.86825148
24Purine metabolism_Homo sapiens_hsa002301.82502536
25Oxidative phosphorylation_Homo sapiens_hsa001901.79921803
26Protein export_Homo sapiens_hsa030601.76985005
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74481100
28Base excision repair_Homo sapiens_hsa034101.73606609
29Non-homologous end-joining_Homo sapiens_hsa034501.73031292
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70127120
31Phototransduction_Homo sapiens_hsa047441.59620563
32Arachidonic acid metabolism_Homo sapiens_hsa005901.59594982
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53670542
34Peroxisome_Homo sapiens_hsa041461.52054832
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47940550
36Sphingolipid metabolism_Homo sapiens_hsa006001.43274600
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40616762
38RNA degradation_Homo sapiens_hsa030181.39125886
39Tight junction_Homo sapiens_hsa045301.37753381
40RNA transport_Homo sapiens_hsa030131.37132612
41Circadian rhythm_Homo sapiens_hsa047101.34520322
42Graft-versus-host disease_Homo sapiens_hsa053321.34502490
43Linoleic acid metabolism_Homo sapiens_hsa005911.32993769
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28743842
45Parkinsons disease_Homo sapiens_hsa050121.25674272
46ABC transporters_Homo sapiens_hsa020101.23442788
47Cell cycle_Homo sapiens_hsa041101.22427314
48Ether lipid metabolism_Homo sapiens_hsa005651.21411286
49Notch signaling pathway_Homo sapiens_hsa043301.21050723
50Autoimmune thyroid disease_Homo sapiens_hsa053201.16033938
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15010410
52Cocaine addiction_Homo sapiens_hsa050301.14262925
53Fatty acid degradation_Homo sapiens_hsa000711.13024571
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10143055
55Allograft rejection_Homo sapiens_hsa053301.09683374
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05347480
57mRNA surveillance pathway_Homo sapiens_hsa030151.03085775
58p53 signaling pathway_Homo sapiens_hsa041151.02656586
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.00267421
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.96173082
61Alzheimers disease_Homo sapiens_hsa050100.93140393
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.92317779
63Other glycan degradation_Homo sapiens_hsa005110.90045186
64Olfactory transduction_Homo sapiens_hsa047400.88702562
65Nicotine addiction_Homo sapiens_hsa050330.88668496
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86105843
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84660881
68Rheumatoid arthritis_Homo sapiens_hsa053230.83387057
69Salivary secretion_Homo sapiens_hsa049700.82384062
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81654805
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.81479552
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80247648
73Epstein-Barr virus infection_Homo sapiens_hsa051690.80148769
74Butanoate metabolism_Homo sapiens_hsa006500.79027401
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77890990
76Asthma_Homo sapiens_hsa053100.77207273
77Collecting duct acid secretion_Homo sapiens_hsa049660.75335970
78Herpes simplex infection_Homo sapiens_hsa051680.75243933
79Systemic lupus erythematosus_Homo sapiens_hsa053220.74355432
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72649344
81Taste transduction_Homo sapiens_hsa047420.70237581
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69274189
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68262787
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.67810374
85Measles_Homo sapiens_hsa051620.67588364
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67539561
87Axon guidance_Homo sapiens_hsa043600.66837827
88Primary immunodeficiency_Homo sapiens_hsa053400.65402017
89One carbon pool by folate_Homo sapiens_hsa006700.65166629
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64967051
91Glutathione metabolism_Homo sapiens_hsa004800.64253465
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63190445
93Nitrogen metabolism_Homo sapiens_hsa009100.61893757
94Starch and sucrose metabolism_Homo sapiens_hsa005000.59282001
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59155138
96Hematopoietic cell lineage_Homo sapiens_hsa046400.58543363
97Type I diabetes mellitus_Homo sapiens_hsa049400.57035550
98Amphetamine addiction_Homo sapiens_hsa050310.56389311
99Mineral absorption_Homo sapiens_hsa049780.53793562
100Metabolic pathways_Homo sapiens_hsa011000.53685783
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53440402
102cAMP signaling pathway_Homo sapiens_hsa040240.52672109
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51460199
104Hippo signaling pathway_Homo sapiens_hsa043900.50440232
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50269006
106Tryptophan metabolism_Homo sapiens_hsa003800.49634190
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48829100
108Synaptic vesicle cycle_Homo sapiens_hsa047210.48345067
109Cardiac muscle contraction_Homo sapiens_hsa042600.46916606
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45696306
111Phagosome_Homo sapiens_hsa041450.45582422
112Glutamatergic synapse_Homo sapiens_hsa047240.45556087
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43349918
114Adherens junction_Homo sapiens_hsa045200.43247506
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41389220
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39701583
117Choline metabolism in cancer_Homo sapiens_hsa052310.39555211
118Serotonergic synapse_Homo sapiens_hsa047260.39058470
119Vitamin digestion and absorption_Homo sapiens_hsa049770.37830526
120Insulin secretion_Homo sapiens_hsa049110.37740923
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37687027
122GABAergic synapse_Homo sapiens_hsa047270.37604009
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37477300
124Influenza A_Homo sapiens_hsa051640.37142129
125Malaria_Homo sapiens_hsa051440.36098260
126Oocyte meiosis_Homo sapiens_hsa041140.35654599
127Dilated cardiomyopathy_Homo sapiens_hsa054140.35613371
128Oxytocin signaling pathway_Homo sapiens_hsa049210.35117935
129Circadian entrainment_Homo sapiens_hsa047130.34329973
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34161336
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32860301
132Steroid biosynthesis_Homo sapiens_hsa001000.31920732
133PPAR signaling pathway_Homo sapiens_hsa033200.31560709
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.31434391
135Hedgehog signaling pathway_Homo sapiens_hsa043400.31432536
136Glycerolipid metabolism_Homo sapiens_hsa005610.31059926
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30264124
138Basal cell carcinoma_Homo sapiens_hsa052170.29663007
139Regulation of autophagy_Homo sapiens_hsa041400.29647793
140Legionellosis_Homo sapiens_hsa051340.29351240
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.28942696
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28794353
143Retinol metabolism_Homo sapiens_hsa008300.28361267
144Arginine and proline metabolism_Homo sapiens_hsa003300.28089798
145Wnt signaling pathway_Homo sapiens_hsa043100.27804546
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27603822
147Calcium signaling pathway_Homo sapiens_hsa040200.27284596
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26598443
149Alcoholism_Homo sapiens_hsa050340.25893608
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25721668
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.25483255
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25219288
153Pentose phosphate pathway_Homo sapiens_hsa000300.24880689
154African trypanosomiasis_Homo sapiens_hsa051430.23631407
155Folate biosynthesis_Homo sapiens_hsa007900.23279826
156Dopaminergic synapse_Homo sapiens_hsa047280.22981156
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22602382
158Melanogenesis_Homo sapiens_hsa049160.22453477
159Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21980358
160TGF-beta signaling pathway_Homo sapiens_hsa043500.21764236
161Morphine addiction_Homo sapiens_hsa050320.21451671

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