TTC24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.77316040
2binding of sperm to zona pellucida (GO:0007339)9.66020067
3spermatid development (GO:0007286)9.62841316
4epithelial cilium movement (GO:0003351)9.58294420
5cell-cell recognition (GO:0009988)9.35061346
6reproduction (GO:0000003)8.87448177
7regulation of cilium movement (GO:0003352)8.86389682
8axonemal dynein complex assembly (GO:0070286)8.83744725
9plasma membrane fusion (GO:0045026)8.82162698
10motile cilium assembly (GO:0044458)8.75553649
11cilium movement (GO:0003341)7.88038854
12negative regulation of inclusion body assembly (GO:0090084)7.45291587
13organic cation transport (GO:0015695)6.88630930
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.72784938
15cilium or flagellum-dependent cell motility (GO:0001539)6.71956888
16spermatid nucleus differentiation (GO:0007289)6.70325858
17sperm capacitation (GO:0048240)6.64611257
18single fertilization (GO:0007338)6.57695399
19spermatogenesis (GO:0007283)6.56217706
20male gamete generation (GO:0048232)6.53497595
21microtubule depolymerization (GO:0007019)6.39732956
22synaptonemal complex organization (GO:0070193)6.18292059
23synaptonemal complex assembly (GO:0007130)6.09571487
24gamete generation (GO:0007276)6.00816879
25regulation of inclusion body assembly (GO:0090083)5.85257490
26sexual reproduction (GO:0019953)5.72910656
27positive thymic T cell selection (GO:0045059)5.70776540
28chromosome condensation (GO:0030261)5.70098481
29fertilization (GO:0009566)5.68588952
30male meiosis (GO:0007140)5.58121605
31negative thymic T cell selection (GO:0045060)5.54226704
32positive regulation of gamma-delta T cell activation (GO:0046645)5.52097416
33calcium ion-dependent exocytosis (GO:0017156)5.45210944
34ventricular system development (GO:0021591)5.37428451
35negative T cell selection (GO:0043383)5.36833017
36DNA packaging (GO:0006323)5.35120302
37positive regulation of B cell differentiation (GO:0045579)5.26868879
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.25508905
39germ cell development (GO:0007281)5.22856176
40single strand break repair (GO:0000012)5.13776014
41piRNA metabolic process (GO:0034587)5.05031035
42regulation of gamma-delta T cell differentiation (GO:0045586)5.02630844
43regulation of microtubule-based movement (GO:0060632)4.98740909
44cellular process involved in reproduction in multicellular organism (GO:0022412)4.96883801
45positive T cell selection (GO:0043368)4.91305996
46antigen processing and presentation of endogenous antigen (GO:0019883)4.87790352
47regulation of B cell differentiation (GO:0045577)4.77876546
48multicellular organismal reproductive process (GO:0048609)4.74951317
49regulation of B cell receptor signaling pathway (GO:0050855)4.74364687
50cell recognition (GO:0008037)4.73316756
51B cell receptor signaling pathway (GO:0050853)4.71636769
52microtubule severing (GO:0051013)4.69209434
53glycerol ether metabolic process (GO:0006662)4.65579559
54RNA localization (GO:0006403)4.64692739
55regulation of gamma-delta T cell activation (GO:0046643)4.59730702
56negative regulation of cell killing (GO:0031342)4.55361122
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55361122
58positive regulation of granulocyte differentiation (GO:0030854)4.52958505
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52285137
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49387808
61Peyers patch development (GO:0048541)4.48774160
62mucosal-associated lymphoid tissue development (GO:0048537)4.48774160
63thymic T cell selection (GO:0045061)4.47179575
64L-ascorbic acid metabolic process (GO:0019852)4.31252037
65T cell migration (GO:0072678)4.29913131
66glucuronate metabolic process (GO:0019585)4.29551782
67uronic acid metabolic process (GO:0006063)4.29551782
68ether metabolic process (GO:0018904)4.27819579
69leukocyte aggregation (GO:0070486)4.26433539
70seminiferous tubule development (GO:0072520)4.22063380
71polyol catabolic process (GO:0046174)4.21665765
72immunoglobulin mediated immune response (GO:0016064)4.14606936
73response to interleukin-15 (GO:0070672)4.09715630
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.07334802
75T cell selection (GO:0045058)4.04318343
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.00628184
77negative regulation of T-helper cell differentiation (GO:0045623)4.00628184
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.98192422
79chromosome organization involved in meiosis (GO:0070192)3.97837095
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.97074756
81cellular response to interleukin-15 (GO:0071350)3.95145083
82multicellular organismal development (GO:0007275)3.90410110
83left/right pattern formation (GO:0060972)3.88390531
84protein K11-linked deubiquitination (GO:0035871)3.83850722
85male meiosis I (GO:0007141)3.81680440
86regulation of alpha-beta T cell proliferation (GO:0046640)3.77991653
87sequestering of actin monomers (GO:0042989)3.73175200
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71610718
89negative regulation of erythrocyte differentiation (GO:0045647)3.69474453
90positive regulation of alpha-beta T cell proliferation (GO:0046641)3.69412340
91regulation of T-helper 1 cell differentiation (GO:0045625)3.66352472
92mast cell activation (GO:0045576)3.59706469
93interferon-gamma production (GO:0032609)3.51143954
94positive regulation of T cell cytokine production (GO:0002726)3.47706207
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.46604948
96defense response to protozoan (GO:0042832)3.46197887
97meiotic nuclear division (GO:0007126)3.41964085
98protein polyglutamylation (GO:0018095)3.35754408
99B cell mediated immunity (GO:0019724)3.33564664
100response to protozoan (GO:0001562)3.32747654
101microtubule polymerization or depolymerization (GO:0031109)3.29403630
102purine deoxyribonucleotide catabolic process (GO:0009155)3.26209000
103regulation of granulocyte differentiation (GO:0030852)3.25793009
104mast cell activation involved in immune response (GO:0002279)3.25564635
105mast cell degranulation (GO:0043303)3.25564635
106genitalia morphogenesis (GO:0035112)3.25467608
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25418573
108antigen receptor-mediated signaling pathway (GO:0050851)3.24539844
109positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22519848
110Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19070338
111regulation of spindle checkpoint (GO:0090231)3.16351447
112positive regulation of B cell activation (GO:0050871)3.13612313
113cellular response to type I interferon (GO:0071357)3.13570273
114type I interferon signaling pathway (GO:0060337)3.13570273
115positive regulation of interleukin-4 production (GO:0032753)3.13548056
116nucleus organization (GO:0006997)3.12954430
117chaperone-mediated protein complex assembly (GO:0051131)3.12575237
118positive regulation of protein homooligomerization (GO:0032464)3.11792617
119DNA methylation involved in gamete generation (GO:0043046)3.11644895
120response to type I interferon (GO:0034340)3.11265768
121negative regulation of T cell mediated immunity (GO:0002710)3.10261998
122negative regulation of lymphocyte mediated immunity (GO:0002707)3.06033964
123positive regulation of alpha-beta T cell differentiation (GO:0046638)3.05218376
124positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.04782718
125positive regulation of interleukin-2 production (GO:0032743)3.03867862
126regulation of interleukin-4 production (GO:0032673)2.99550340
127leukocyte degranulation (GO:0043299)2.99377792
128glycolytic process (GO:0006096)2.98372291
129response to muramyl dipeptide (GO:0032495)2.97478645
130regulation of response to osmotic stress (GO:0047484)2.97008768
131alditol metabolic process (GO:0019400)2.93361781
132regulation of antigen processing and presentation (GO:0002577)2.92869795
133T cell homeostasis (GO:0043029)2.92733743
134mature B cell differentiation involved in immune response (GO:0002313)2.92141097
135interferon-gamma-mediated signaling pathway (GO:0060333)2.91149096
136positive regulation of macrophage activation (GO:0043032)2.90803005
137regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89905171
138regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89208348
139centriole assembly (GO:0098534)2.88969448
140positive regulation of alpha-beta T cell activation (GO:0046635)2.88943065
141deoxyribonucleotide catabolic process (GO:0009264)2.88459425
142negative regulation of leukocyte mediated immunity (GO:0002704)2.88383754
143regulation of alpha-beta T cell activation (GO:0046634)2.86418004
144regulation of alpha-beta T cell differentiation (GO:0046637)2.86358836
145negative regulation of innate immune response (GO:0045824)2.85519775
146polyamine biosynthetic process (GO:0006596)2.84805521
147protein-DNA complex disassembly (GO:0032986)2.84355184
148nucleosome disassembly (GO:0006337)2.84355184
149negative regulation of alpha-beta T cell activation (GO:0046636)2.83769769
150regulation of regulatory T cell differentiation (GO:0045589)2.82772263
151negative regulation of type I interferon production (GO:0032480)2.81498225
152regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.80854612
153meiosis I (GO:0007127)2.80752372
154cellular response to exogenous dsRNA (GO:0071360)2.80199647
155T cell receptor signaling pathway (GO:0050852)2.79735295
156myeloid cell activation involved in immune response (GO:0002275)2.78139747
157regulation of T-helper 2 cell differentiation (GO:0045628)2.78106159
158chromatin silencing (GO:0006342)2.77812121
159positive regulation of isotype switching (GO:0045830)2.77786697
160negative regulation of thymocyte apoptotic process (GO:0070244)2.77542605
161protein refolding (GO:0042026)2.77469954
162phenylpropanoid metabolic process (GO:0009698)2.76860227
163cilium organization (GO:0044782)2.76641944
164B cell homeostasis (GO:0001782)2.76520878
165xenobiotic catabolic process (GO:0042178)2.75965810
166neutrophil activation involved in immune response (GO:0002283)2.74775529
167positive regulation of T cell differentiation (GO:0045582)2.74416266
168deoxyribose phosphate catabolic process (GO:0046386)2.74372215
169regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72886593
170positive regulation of B cell proliferation (GO:0030890)2.71948163
171regulation of T cell cytokine production (GO:0002724)2.71351404
172detection of bacterium (GO:0016045)2.71145872
173regulation of B cell activation (GO:0050864)2.71107184
174positive regulation of immunoglobulin production (GO:0002639)2.70176756
175negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69156713
176cilium assembly (GO:0042384)2.68956120
177protein localization to cilium (GO:0061512)2.66278816
178carnitine transport (GO:0015879)2.64259373
179amino-acid betaine transport (GO:0015838)2.64259373
180intraciliary transport (GO:0042073)2.62171689
181glycerol metabolic process (GO:0006071)2.60750209
182cellular glucuronidation (GO:0052695)2.55777107
183nucleoside diphosphate phosphorylation (GO:0006165)2.55388785
184cellular component assembly involved in morphogenesis (GO:0010927)2.54549536
185interferon-gamma secretion (GO:0072643)2.50927493
186regulation of cytokine production involved in inflammatory response (GO:1900015)2.50837707
187mitotic sister chromatid cohesion (GO:0007064)2.50691750
188RNA destabilization (GO:0050779)2.49416551
189water-soluble vitamin biosynthetic process (GO:0042364)2.49359242
190carnitine transmembrane transport (GO:1902603)2.48296363
191meiotic cell cycle (GO:0051321)2.48114992
192hormone catabolic process (GO:0042447)2.47244551
193sperm motility (GO:0030317)13.7498482
194cell wall macromolecule catabolic process (GO:0016998)13.6581250
195cell wall macromolecule metabolic process (GO:0044036)13.6581250
196fusion of sperm to egg plasma membrane (GO:0007342)11.6888178
197acrosome reaction (GO:0007340)11.6351889
198sperm-egg recognition (GO:0035036)10.4872437
199acrosome assembly (GO:0001675)10.1223725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.14079920
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.30908552
3EZH2_22144423_ChIP-Seq_EOC_Human4.40310375
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11260757
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.71770644
6MYC_22102868_ChIP-Seq_BL_Human3.60878132
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.54960692
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53751110
9E2F7_22180533_ChIP-Seq_HELA_Human3.23800033
10RUNX_20019798_ChIP-Seq_JUKART_Human3.21802510
11MYB_26560356_Chip-Seq_TH2_Human3.13381006
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12589731
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04536697
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01634704
15VDR_21846776_ChIP-Seq_THP-1_Human2.86813685
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85079991
17SCL_19346495_ChIP-Seq_HPC-7_Human2.81418789
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80986362
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78252049
20* UTX_26944678_Chip-Seq_JUKART_Human2.73745204
21VDR_22108803_ChIP-Seq_LS180_Human2.64704645
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.59853550
23CIITA_25753668_ChIP-Seq_RAJI_Human2.57181557
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.56512852
25MAF_26560356_Chip-Seq_TH1_Human2.52682119
26MYB_26560356_Chip-Seq_TH1_Human2.50674640
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50137904
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49546294
29VDR_24763502_ChIP-Seq_THP-1_Human2.44133507
30SPI1_23547873_ChIP-Seq_NB4_Human2.42937026
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32461710
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29562279
33GATA1_26923725_Chip-Seq_HPCs_Mouse2.21126379
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17924675
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12872370
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12417436
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12170407
38GATA3_27048872_Chip-Seq_THYMUS_Human2.11785763
39STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04610178
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02931943
41EGR1_19374776_ChIP-ChIP_THP-1_Human2.01628496
42RUNX1_22412390_ChIP-Seq_EML_Mouse2.00885187
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97674941
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97139052
45MAF_26560356_Chip-Seq_TH2_Human1.96643744
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.95939641
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94921215
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.92905884
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92461767
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.92285967
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.87719996
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87108336
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.85290427
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78764297
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77126551
56TCF7_22412390_ChIP-Seq_EML_Mouse1.77116718
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76338267
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75575358
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72885312
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72373796
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69906856
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67961692
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.66185643
64* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61123994
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59965672
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.59068649
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56275453
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55233670
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54927667
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54542582
71KDM2B_26808549_Chip-Seq_DND41_Human1.54359520
72STAT1_17558387_ChIP-Seq_HELA_Human1.54283203
73SPI1_23127762_ChIP-Seq_K562_Human1.54026426
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52898462
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48627642
76KDM2B_26808549_Chip-Seq_REH_Human1.47604332
77FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47361626
78TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.46782036
79GATA3_21867929_ChIP-Seq_CD8_Mouse1.46099943
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45065776
81GATA3_26560356_Chip-Seq_TH2_Human1.44170369
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43823654
83SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42096323
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41939000
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41291659
86REST_21632747_ChIP-Seq_MESCs_Mouse1.41215750
87VDR_23849224_ChIP-Seq_CD4+_Human1.40083106
88FOXP3_21729870_ChIP-Seq_TREG_Human1.36979292
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36537367
90ZNF274_21170338_ChIP-Seq_K562_Hela1.36048948
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31838421
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31302820
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30719517
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30607103
95TAF15_26573619_Chip-Seq_HEK293_Human1.29657759
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29276324
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29163165
98RNF2_27304074_Chip-Seq_NSC_Mouse1.27551973
99GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.27381718
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26858266
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25617370
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24279989
103CBP_20019798_ChIP-Seq_JUKART_Human1.24279989
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23986178
105BCL6_27268052_Chip-Seq_Bcells_Human1.23556201
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21872403
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20540789
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20504722
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.19453978
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19251677
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.18036304
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17549053
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17549053
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17154958
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17146645
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.16425622
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16366636
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16231529
119GATA1_22025678_ChIP-Seq_K562_Human1.15920520
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14635359
121GATA3_21867929_ChIP-Seq_TH1_Mouse1.14590151
122GF1_26923725_Chip-Seq_HPCs_Mouse1.13352163
123KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12567883
124ESET_19884257_ChIP-Seq_ESCs_Mouse1.12181937
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11768357
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10396569
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.10225135
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10058442
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09923449
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09193723
131SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08892912
132AHR_22903824_ChIP-Seq_MCF-7_Human1.08439177
133EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07761160
134NOTCH1_21737748_ChIP-Seq_TLL_Human1.07745473
135BCOR_27268052_Chip-Seq_Bcells_Human1.07546087
136MYC_27129775_Chip-Seq_CORNEA_Mouse1.07377963
137* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07228591
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07173865
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07140247
140NANOG_18555785_Chip-Seq_ESCs_Mouse1.06921163
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06703053
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06408832
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05711485
144CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05109158
145ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05052845
146OCT4_18555785_Chip-Seq_ESCs_Mouse1.04641957
147ARNT_22903824_ChIP-Seq_MCF-7_Human1.03574652
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03561478
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03255810
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03061071
151P53_21459846_ChIP-Seq_SAOS-2_Human1.02126174
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02040767
153SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01964812
154STAT3_18555785_ChIP-Seq_MESCs_Mouse1.01597928
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01116976
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00324282
157ERG_20517297_ChIP-Seq_VCAP_Human1.00265528
158* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99344671
159RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98938595
160P300_27268052_Chip-Seq_Bcells_Human0.97520830
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.96842505
162CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96383218
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96275949
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.95612964
165P68_20966046_ChIP-Seq_HELA_Human0.95465170
166PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95307089
167RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95024219
168SPI1_26923725_Chip-Seq_HPCs_Mouse0.94566866
169OCT1_27270436_Chip-Seq_PROSTATE_Human0.94527457
170GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94228176
171* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92961316
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.92761966
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92236583
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90714103
175P53_22387025_ChIP-Seq_ESCs_Mouse0.90445030
176CTCF_27219007_Chip-Seq_Bcells_Human0.90381986
177CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90246086
178KLF4_18555785_Chip-Seq_ESCs_Mouse0.90173444
179FUS_26573619_Chip-Seq_HEK293_Human0.90086829
180ELK3_25401928_ChIP-Seq_HUVEC_Human0.89696415
181SOX9_26525672_Chip-Seq_HEART_Mouse0.89661673
182ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89382612
183SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88695855
184SOX2_18555785_Chip-Seq_ESCs_Mouse0.88451191
185TET1_21451524_ChIP-Seq_MESCs_Mouse0.86860820
186GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86839519
187ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86743531
188NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86574881
189RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86537559
190* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85885775
191NCOR1_26117541_ChIP-Seq_K562_Human0.85628112
192SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83469439
193VDR_24787735_ChIP-Seq_THP-1_Human0.83319098
194PU_27001747_Chip-Seq_BMDM_Mouse0.81600106
195PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80354123
196HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79254044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.87937713
2MP0001929_abnormal_gametogenesis4.40205074
3MP0001835_abnormal_antigen_presentation4.36040420
4MP0005394_taste/olfaction_phenotype4.26379316
5MP0005499_abnormal_olfactory_system4.26379316
6MP0003763_abnormal_thymus_physiology4.25744202
7MP0002396_abnormal_hematopoietic_system3.72411664
8MP0005671_abnormal_response_to3.71282535
9MP0008789_abnormal_olfactory_epithelium3.59991157
10MP0001800_abnormal_humoral_immune3.47347238
11MP0001984_abnormal_olfaction3.29638993
12MP0000685_abnormal_immune_system3.26361065
13MP0005000_abnormal_immune_tolerance3.13812072
14MP0003436_decreased_susceptibility_to3.06535067
15MP0002420_abnormal_adaptive_immunity2.96478016
16MP0001819_abnormal_immune_cell2.90658902
17MP0002398_abnormal_bone_marrow2.85218327
18MP0002452_abnormal_antigen_presenting2.79698713
19MP0002723_abnormal_immune_serum2.79393493
20MP0001790_abnormal_immune_system2.67084252
21MP0005387_immune_system_phenotype2.67084252
22MP0005025_abnormal_response_to2.67049107
23MP0005377_hearing/vestibular/ear_phenot2.64642476
24MP0003878_abnormal_ear_physiology2.64642476
25MP0002161_abnormal_fertility/fecundity2.64315600
26MP0010030_abnormal_orbit_morphology2.64128011
27MP0002210_abnormal_sex_determination2.61116243
28MP0009278_abnormal_bone_marrow2.55945650
29MP0000716_abnormal_immune_system2.54876237
30MP0002653_abnormal_ependyma_morphology2.52242126
31MP0002419_abnormal_innate_immunity2.41793394
32MP0000703_abnormal_thymus_morphology2.39980570
33MP0002148_abnormal_hypersensitivity_rea2.35638238
34MP0000689_abnormal_spleen_morphology2.34321226
35MP0009785_altered_susceptibility_to2.32956860
36MP0005464_abnormal_platelet_physiology2.30890007
37MP0002722_abnormal_immune_system2.26210171
38MP0001145_abnormal_male_reproductive2.23190084
39MP0008877_abnormal_DNA_methylation2.21722503
40MP0003724_increased_susceptibility_to2.21519434
41MP0002429_abnormal_blood_cell2.11302768
42MP0005410_abnormal_fertilization13.6099231
43MP0002405_respiratory_system_inflammati1.97930934
44MP0000653_abnormal_sex_gland1.95313485
45MP0009333_abnormal_splenocyte_physiolog1.90631536
46MP0010155_abnormal_intestine_physiology1.87861589
47MP0001853_heart_inflammation1.79175930
48MP0005670_abnormal_white_adipose1.72341760
49MP0004808_abnormal_hematopoietic_stem1.69293279
50MP0002160_abnormal_reproductive_system1.68962990
51MP0003866_abnormal_defecation1.66289732
52MP0002166_altered_tumor_susceptibility1.64053060
53MP0003303_peritoneal_inflammation1.63879419
54MP0000465_gastrointestinal_hemorrhage1.63728122
55MP0005075_abnormal_melanosome_morpholog1.60553880
56MP0004947_skin_inflammation1.60536857
57MP0002138_abnormal_hepatobiliary_system1.55233057
58MP0005397_hematopoietic_system_phenotyp1.53382032
59MP0001545_abnormal_hematopoietic_system1.53382032
60MP0001845_abnormal_inflammatory_respons1.51760214
61MP0000372_irregular_coat_pigmentation1.49109924
62MP0004381_abnormal_hair_follicle1.46076708
63MP0002233_abnormal_nose_morphology1.43626242
64MP0005248_abnormal_Harderian_gland1.42939250
65MP0008057_abnormal_DNA_replication1.40844461
66MP0003183_abnormal_peptide_metabolism1.40320266
67MP0002019_abnormal_tumor_incidence1.39650881
68MP0003300_gastrointestinal_ulcer1.38028060
69MP0001346_abnormal_lacrimal_gland1.36869120
70MP0005257_abnormal_intraocular_pressure1.33289698
71MP0001873_stomach_inflammation1.33180868
72MP0003136_yellow_coat_color1.33091217
73MP0000534_abnormal_ureter_morphology1.28717448
74MP0005647_abnormal_sex_gland1.24378379
75MP0002009_preneoplasia1.23750772
76MP0000678_abnormal_parathyroid_gland1.23642585
77MP0008469_abnormal_protein_level1.22687533
78MP0002006_tumorigenesis1.18621252
79MP0000858_altered_metastatic_potential1.18238440
80MP0001986_abnormal_taste_sensitivity1.16816366
81MP0003011_delayed_dark_adaptation1.15480930
82MP0006292_abnormal_olfactory_placode1.12998182
83MP0010094_abnormal_chromosome_stability1.11245092
84MP0005310_abnormal_salivary_gland1.09757671
85MP0001533_abnormal_skeleton_physiology1.09276194
86MP0000490_abnormal_crypts_of1.06220022
87MP0000049_abnormal_middle_ear1.05408307
88MP0009764_decreased_sensitivity_to1.02867212
89MP0006082_CNS_inflammation1.02787406
90MP0002933_joint_inflammation1.01294495
91MP0002277_abnormal_respiratory_mucosa1.00707320
92MP0002282_abnormal_trachea_morphology0.96379749
93MP0005451_abnormal_body_composition0.89610047
94MP0005389_reproductive_system_phenotype0.87198134
95MP0001485_abnormal_pinna_reflex0.85277907
96MP0000762_abnormal_tongue_morphology0.85259768
97MP0003191_abnormal_cellular_cholesterol0.84548051
98MP0002249_abnormal_larynx_morphology0.84335955
99MP0001765_abnormal_ion_homeostasis0.83475048
100MP0005645_abnormal_hypothalamus_physiol0.82758195
101MP0003786_premature_aging0.82471205
102MP0005623_abnormal_meninges_morphology0.81833962
103MP0002998_abnormal_bone_remodeling0.80938452
104MP0004233_abnormal_muscle_weight0.79794095
105MP0003787_abnormal_imprinting0.79047980
106MP0004510_myositis0.77891414
107MP0009763_increased_sensitivity_to0.77136988
108MP0000026_abnormal_inner_ear0.76567853
109MP0002234_abnormal_pharynx_morphology0.76196326
110MP0002132_abnormal_respiratory_system0.74652221
111MP0001963_abnormal_hearing_physiology0.72337457
112MP0002693_abnormal_pancreas_physiology0.72089267
113MP0003879_abnormal_hair_cell0.67734693
114MP0004134_abnormal_chest_morphology0.66841671
115MP0003252_abnormal_bile_duct0.66500039
116MP0002254_reproductive_system_inflammat0.65798944
117MP0003448_altered_tumor_morphology0.65294297
118MP0000613_abnormal_salivary_gland0.64015300
119MP0009250_abnormal_appendicular_skeleto0.63138068
120MP0002102_abnormal_ear_morphology0.63087595
121MP0001293_anophthalmia0.62669091
122MP0002092_abnormal_eye_morphology0.62643643
123MP0008260_abnormal_autophagy0.62625510
124MP0003755_abnormal_palate_morphology0.61982847
125MP0001849_ear_inflammation0.61287660
126MP0000313_abnormal_cell_death0.60632565
127MP0010234_abnormal_vibrissa_follicle0.60149225
128MP0002083_premature_death0.60020477
129MP0006072_abnormal_retinal_apoptosis0.59054288
130MP0001663_abnormal_digestive_system0.58758913
131MP0003045_fibrosis0.58492168
132MP0003942_abnormal_urinary_system0.58474852
133MP0001270_distended_abdomen0.58114052
134MP0003806_abnormal_nucleotide_metabolis0.56562567
135MP0005166_decreased_susceptibility_to0.56215565
136MP0009765_abnormal_xenobiotic_induced0.56046941
137MP0003186_abnormal_redox_activity0.55734710
138MP0001324_abnormal_eye_pigmentation0.55607674
139MP0008007_abnormal_cellular_replicative0.55497250
140MP0003795_abnormal_bone_structure0.54575723
141MP0005391_vision/eye_phenotype0.53690665
142MP0003938_abnormal_ear_development0.53507541
143MP0001486_abnormal_startle_reflex0.53014486
144MP0001919_abnormal_reproductive_system0.52398356
145MP0002752_abnormal_somatic_nervous0.52020098
146MP0003075_altered_response_to0.51895232
147MP0003172_abnormal_lysosome_physiology0.51874641
148MP0000383_abnormal_hair_follicle0.51592674
149MP0003115_abnormal_respiratory_system0.51274340
150MP0008961_abnormal_basal_metabolism0.50910015
151MP0003329_amyloid_beta_deposits0.50105656
152MP0005220_abnormal_exocrine_pancreas0.49956544
153MP0006036_abnormal_mitochondrial_physio0.49881975
154MP0000249_abnormal_blood_vessel0.48012038
155MP0005253_abnormal_eye_physiology0.45971536
156MP0008872_abnormal_physiological_respon0.45563720
157MP0004883_abnormal_blood_vessel0.44739102
158MP0000681_abnormal_thyroid_gland0.44537180
159MP0008995_early_reproductive_senescence0.44333723
160MP0000566_synostosis0.43115311
161MP0000598_abnormal_liver_morphology0.42832033
162MP0003077_abnormal_cell_cycle0.42771568
163MP0005390_skeleton_phenotype0.42265971
164MP0002116_abnormal_craniofacial_bone0.41730869
165MP0003111_abnormal_nucleus_morphology0.41697526
166MP0005535_abnormal_body_temperature0.41067922
167MP0008875_abnormal_xenobiotic_pharmacok0.40686884
168MP0008873_increased_physiological_sensi0.40605410
169MP0002876_abnormal_thyroid_physiology0.39658962
170MP0004742_abnormal_vestibular_system0.39416249
171MP0000631_abnormal_neuroendocrine_gland0.38420323
172MP0005551_abnormal_eye_electrophysiolog0.37791648
173MP0004133_heterotaxia0.36335873
174MP0003861_abnormal_nervous_system0.36119747
175MP0009046_muscle_twitch0.35660062
176MP0002932_abnormal_joint_morphology0.34661006
177MP0005195_abnormal_posterior_eye0.34635997
178MP0002177_abnormal_outer_ear0.33690243
179MP0002229_neurodegeneration0.33535807
180MP0002882_abnormal_neuron_morphology0.32958466
181MP0008058_abnormal_DNA_repair0.32481741
182MP0006035_abnormal_mitochondrial_morpho0.32338740
183MP0000432_abnormal_head_morphology0.31245751
184MP0005636_abnormal_mineral_homeostasis0.30974646
185MP0010329_abnormal_lipoprotein_level0.30648073
186MP0002734_abnormal_mechanical_nocicepti0.30175385
187MP0004885_abnormal_endolymph0.30027235
188MP0002272_abnormal_nervous_system0.29859692
189MP0003283_abnormal_digestive_organ0.28829820
190MP0004019_abnormal_vitamin_homeostasis0.28514926
191MP0002877_abnormal_melanocyte_morpholog0.27679244
192MP0001851_eye_inflammation0.27232791
193MP0003937_abnormal_limbs/digits/tail_de0.26400850
194MP0003890_abnormal_embryonic-extraembry0.26397990

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.06269095
2Abnormal respiratory motile cilium morphology (HP:0005938)9.00308037
3Abnormal respiratory epithelium morphology (HP:0012253)9.00308037
4Abnormal ciliary motility (HP:0012262)7.64188536
5Agammaglobulinemia (HP:0004432)7.15859806
6Panhypogammaglobulinemia (HP:0003139)7.07009113
7Rhinitis (HP:0012384)6.72371775
8Chronic bronchitis (HP:0004469)6.61827791
9Infertility (HP:0000789)6.10456978
10Nasal polyposis (HP:0100582)5.77235201
11Severe combined immunodeficiency (HP:0004430)5.05613964
12Abnormal delayed hypersensitivity skin test (HP:0002963)5.01898849
13Recurrent viral infections (HP:0004429)4.79857845
14Meningitis (HP:0001287)4.69739956
15Abnormality of the nasal mucosa (HP:0000433)4.62377423
16Recurrent fungal infections (HP:0002841)4.61610461
17B lymphocytopenia (HP:0010976)4.59164836
18Elevated erythrocyte sedimentation rate (HP:0003565)4.42508999
19Abnormality of B cell number (HP:0010975)4.42400797
20T lymphocytopenia (HP:0005403)4.21947597
21Combined immunodeficiency (HP:0005387)4.09617502
22Cellulitis (HP:0100658)4.08565101
23Recurrent cutaneous fungal infections (HP:0011370)4.05875455
24Chronic mucocutaneous candidiasis (HP:0002728)4.05875455
25Bronchiectasis (HP:0002110)3.97655891
26Eczematoid dermatitis (HP:0000976)3.96719221
27Granulocytopenia (HP:0001913)3.95891596
28Abnormality of T cells (HP:0002843)3.91279306
29Male infertility (HP:0003251)3.89926256
30Stomatitis (HP:0010280)3.87799097
31Increased IgE level (HP:0003212)3.77249762
32Abnormality of T cell number (HP:0011839)3.75270167
33Autoimmune hemolytic anemia (HP:0001890)3.69563782
34Bronchitis (HP:0012387)3.67205654
35Recurrent abscess formation (HP:0002722)3.61602674
36Abnormality of T cell physiology (HP:0011840)3.60274121
37Acute lymphatic leukemia (HP:0006721)3.57710838
38IgG deficiency (HP:0004315)3.56297567
39Encephalitis (HP:0002383)3.55877891
40Myositis (HP:0100614)3.53814107
41Verrucae (HP:0200043)3.41520630
42Papilloma (HP:0012740)3.41520630
43Gastrointestinal inflammation (HP:0004386)3.40177765
44Recurrent bacterial skin infections (HP:0005406)3.39804212
45Nephronophthisis (HP:0000090)3.37930019
46Inflammation of the large intestine (HP:0002037)3.32912168
47Mediastinal lymphadenopathy (HP:0100721)3.26862582
48Colitis (HP:0002583)3.21053781
49Abnormality of the prostate (HP:0008775)3.18272232
50Eosinophilia (HP:0001880)3.10166867
51Recurrent skin infections (HP:0001581)3.09146349
52Abnormal spermatogenesis (HP:0008669)2.98243313
53Hypoplasia of the thymus (HP:0000778)2.95281454
54Recurrent sinusitis (HP:0011108)2.95269881
55Chronic otitis media (HP:0000389)2.92847443
56Pustule (HP:0200039)2.91381337
57IgM deficiency (HP:0002850)2.88262986
58Sepsis (HP:0100806)2.87858414
59Viral hepatitis (HP:0006562)2.85925874
60Chronic obstructive pulmonary disease (HP:0006510)2.81867020
61Obstructive lung disease (HP:0006536)2.81867020
62Vasculitis (HP:0002633)2.76884180
63Thyroiditis (HP:0100646)2.75779629
64Osteomyelitis (HP:0002754)2.75751406
65Abnormality of eosinophils (HP:0001879)2.75385219
66Leukocytosis (HP:0001974)2.74329850
67Recurrent otitis media (HP:0000403)2.70802450
68Chronic sinusitis (HP:0011109)2.68231005
69Aplasia/Hypoplasia of the thymus (HP:0010515)2.67529050
70Lymphopenia (HP:0001888)2.67216785
71Impulsivity (HP:0100710)2.67053225
72Chest pain (HP:0100749)2.65793166
73Abnormality of the renal medulla (HP:0100957)2.64257101
74Thrombocytosis (HP:0001894)2.63750372
75Prolonged bleeding time (HP:0003010)2.62633299
76Medial flaring of the eyebrow (HP:0010747)2.59365649
77Abnormality of midbrain morphology (HP:0002418)2.52147380
78Molar tooth sign on MRI (HP:0002419)2.52147380
79Spontaneous hematomas (HP:0007420)2.44824688
80Prostate neoplasm (HP:0100787)2.44092257
81Epistaxis (HP:0000421)2.43065921
82Autoimmune thrombocytopenia (HP:0001973)2.41979083
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.41510209
84Recurrent lower respiratory tract infections (HP:0002783)2.41019342
85Abnormality of macrophages (HP:0004311)2.36206015
86Tubulointerstitial nephritis (HP:0001970)2.29885670
87Skin rash (HP:0000988)2.29545129
88Papilledema (HP:0001085)2.28779223
89Orchitis (HP:0100796)2.28542563
90Recurrent pneumonia (HP:0006532)2.23747647
91Optic neuritis (HP:0100653)2.22849720
92Retrobulbar optic neuritis (HP:0100654)2.22849720
93Chronic diarrhea (HP:0002028)2.22137034
94Hypergammaglobulinemia (HP:0010702)2.21453561
95Gastrointestinal stroma tumor (HP:0100723)2.20817696
96Basal cell carcinoma (HP:0002671)2.16853780
97Lymphoma (HP:0002665)2.15760910
98Pulmonary infiltrates (HP:0002113)2.12122263
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12072903
100Degeneration of the lateral corticospinal tracts (HP:0002314)2.12072903
101Tubulointerstitial abnormality (HP:0001969)2.10903552
102Urticaria (HP:0001025)2.09576762
103Tubular atrophy (HP:0000092)2.05971989
104Gingival bleeding (HP:0000225)2.04841146
105Abnormality of the thymus (HP:0000777)2.03214011
106Skin ulcer (HP:0200042)2.00670970
107Facial cleft (HP:0002006)2.00240963
108Abnormal biliary tract physiology (HP:0012439)2.00051201
109Bile duct proliferation (HP:0001408)2.00051201
110Dynein arm defect of respiratory motile cilia (HP:0012255)12.5884737
111Absent/shortened dynein arms (HP:0200106)12.5884737
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8867166
113Dyschromatopsia (HP:0007641)1.99275083
114Gastrointestinal infarctions (HP:0005244)1.98632760
115Increased IgM level (HP:0003496)1.97967045
116Nephrogenic diabetes insipidus (HP:0009806)1.97149705
117Abnormality of permanent molar morphology (HP:0011071)1.93394613
118Abnormality of the dental root (HP:0006486)1.93394613
119Taurodontia (HP:0000679)1.93394613
120Arterial thrombosis (HP:0004420)1.91423208
121Abnormality of male internal genitalia (HP:0000022)1.90987491
122Recurrent gram-negative bacterial infections (HP:0005420)1.90684544
123Abnormality of the columella (HP:0009929)1.88840282
124Amaurosis fugax (HP:0100576)1.88466889
125Fatigue (HP:0012378)1.88165850
126Abnormality of the corticospinal tract (HP:0002492)1.87953311
127Short ribs (HP:0000773)1.84691252
128Aplasia/Hypoplasia affecting the retina (HP:0008061)1.84380022
129Cholecystitis (HP:0001082)1.84324335
130Abnormal gallbladder physiology (HP:0012438)1.84324335
131Azoospermia (HP:0000027)1.83710422
132Postaxial foot polydactyly (HP:0001830)1.82024204
133Polygenic inheritance (HP:0010982)1.80404729
134Double outlet right ventricle (HP:0001719)1.79842486
135Congenital malformation of the right heart (HP:0011723)1.79842486
136Neutropenia (HP:0001875)1.79772721
137Abnormality of molar morphology (HP:0011070)1.79384143
138Abnormality of molar (HP:0011077)1.79384143
139Petechiae (HP:0000967)1.79197975
140Aplasia/Hypoplasia of the lens (HP:0008063)1.78922619
141Tubulointerstitial fibrosis (HP:0005576)1.77745859
142Dysphonia (HP:0001618)1.77729633
143Congenital hepatic fibrosis (HP:0002612)1.75188301
144Abnormality of the dental pulp (HP:0006479)1.73953446
145Renal dysplasia (HP:0000110)1.73816400
146Reduced antithrombin III activity (HP:0001976)1.73348518
147Aplasia/Hypoplasia of the macula (HP:0008059)1.72801364
148Hypoproteinemia (HP:0003075)1.72429649
149Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72042172
150Abnormality of dentin (HP:0010299)1.71438018
151Recurrent bronchitis (HP:0002837)1.70790896
152Postaxial hand polydactyly (HP:0001162)1.69786421
153Leukopenia (HP:0001882)1.69048744
154Episodic fever (HP:0001954)1.68165496
155IgA deficiency (HP:0002720)1.67410722
156Decreased central vision (HP:0007663)1.66427689
157Gait imbalance (HP:0002141)1.65351181
158Abnormality of the pleura (HP:0002103)1.64294371
159Acute hepatic failure (HP:0006554)1.63716658
160Congenital primary aphakia (HP:0007707)1.62359917
161Choroideremia (HP:0001139)1.62224914
162Sensory axonal neuropathy (HP:0003390)1.61537519
163Upper limb muscle weakness (HP:0003484)1.58657514
164Preauricular pit (HP:0004467)1.53750215
165Periauricular skin pits (HP:0100277)1.53750215
166Bilateral microphthalmos (HP:0007633)1.53274343
167Abnormal lung lobation (HP:0002101)1.52572005
168Hypoplastic scapulae (HP:0000882)1.50744105
169Aplasia/Hypoplasia of the scapulae (HP:0006713)1.50744105
170Bell-shaped thorax (HP:0001591)1.46044838
171Optic nerve hypoplasia (HP:0000609)1.46006733
172Spastic tetraparesis (HP:0001285)1.45133136
173Polydipsia (HP:0001959)1.44106498
174Abnormal drinking behavior (HP:0030082)1.44106498
175Hemiparesis (HP:0001269)1.43595132
176Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.43249572
177Lip pit (HP:0100267)1.43121496
178Short nail (HP:0001799)1.38649530
179Median cleft lip (HP:0000161)1.36222792
180Absent eyebrow (HP:0002223)1.35509749
181Papillary thyroid carcinoma (HP:0002895)1.34632146
182Skin pits (HP:0100276)1.34425845
183Abnormality of renal excretion (HP:0011036)1.34135042
184Bifid tongue (HP:0010297)1.33230163
185Neurofibrillary tangles (HP:0002185)1.31909932
186Degeneration of anterior horn cells (HP:0002398)1.31547270
187Abnormality of the anterior horn cell (HP:0006802)1.31547270
188Vaginal atresia (HP:0000148)1.30899965
189Gonadotropin excess (HP:0000837)1.30758371
190Renal tubular acidosis (HP:0001947)1.30195247
191Genital tract atresia (HP:0001827)1.27795032
192Bundle branch block (HP:0011710)1.27394428
193Conjugated hyperbilirubinemia (HP:0002908)1.26609424
194Abnormality of the lower motor neuron (HP:0002366)1.25796451
195Nephropathy (HP:0000112)1.24555118
196Stage 5 chronic kidney disease (HP:0003774)1.24300675
197Pancreatic fibrosis (HP:0100732)1.22980246
198Short thorax (HP:0010306)1.21940393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.98338597
2PDK47.98338597
3TESK15.47244632
4TXK5.13555273
5PDK25.02828235
6MAP4K14.94847725
7ICK3.73307080
8PRKD33.63497905
9PRPF4B2.60484301
10KIT2.59351829
11SYK2.33656401
12ERN12.32468117
13BTK2.17693766
14FES2.13245631
15ITK2.11250659
16SCYL22.05321961
17TAOK32.00112464
18ZAP701.97345237
19TYK21.94984465
20IKBKE1.85887427
21PTK2B1.85044703
22PBK1.82280710
23STK381.79283726
24DYRK1B1.76994559
25TNK21.76220638
26TEC1.75731514
27MAPK151.72321074
28MAP4K21.70344448
29PNCK1.68471656
30JAK31.63180682
31TGFBR21.62881816
32BCKDK1.54803549
33STK391.53235109
34VRK21.51377391
35FLT31.50142863
36BLK1.44468166
37MOS1.43365970
38MAP3K131.38444295
39RIPK41.38056874
40HCK1.37539850
41MAP2K31.37270374
42LYN1.36659338
43PDK11.36272386
44LCK1.33163753
45SIK21.31735947
46IRAK41.31348632
47MAP3K141.31233387
48GRK51.27486966
49WNK41.25490518
50PIK3CG1.21874144
51TYRO31.21538431
52MAP3K101.20352589
53CDK121.14674151
54TESK21.11037755
55KDR1.03588080
56NEK21.02512491
57LATS10.99635927
58TRIB30.97926039
59MAP2K60.97342232
60IRAK10.96340967
61JAK10.95775290
62GRK10.95016240
63PRKCQ0.93214145
64TTK0.90917133
65DAPK10.90306792
66PDPK10.90145864
67GRK60.89936577
68CSK0.88854057
69MAPK110.88128984
70IKBKB0.88096517
71CDK40.87950001
72SMG10.86300958
73JAK20.82590780
74MAP3K110.77600252
75TLK10.77098611
76NLK0.75451628
77SIK30.72288630
78CDK190.71542028
79MARK20.71502237
80NUAK10.68994970
81CAMKK10.66482482
82STK30.65685243
83WNK10.64964618
84PKN20.64187957
85PIM10.60741210
86TAOK20.60546079
87BRD40.58173589
88MARK30.57162828
89MAPK120.56875789
90MAP2K70.55776181
91EIF2AK20.54269009
92CDC70.51579997
93STK38L0.50329317
94ADRBK20.50185166
95MAP3K10.50024272
96PINK10.49910305
97LMTK20.49634294
98CHEK20.49486943
99IRAK20.49199526
100VRK10.47673458
101CAMK1G0.47358844
102PRKCH0.46565658
103DYRK30.46233152
104TAF10.44340758
105NTRK20.42758703
106PAK10.41576827
107CSF1R0.40756277
108PRKCG0.39946026
109FYN0.38915209
110DDR20.38596501
111FGFR30.38563536
112MATK0.37528615
113FRK0.37117899
114BMPR20.36405125
115ATR0.36166475
116IGF1R0.35414187
117PRKCZ0.35330695
118MAPK30.35225110
119MAPKAPK50.35039137
120CHEK10.33999519
121EPHA20.33181382
122STK40.32959087
123MST40.31633375
124LRRK20.31193444
125MAPK40.30960550
126PRKD20.30787164
127CDC42BPA0.30719025
128MTOR0.30389954
129CDK70.29913299
130CDK90.27887899
131MAP3K60.27161783
132TAOK10.26927559
133RPS6KL10.26054619
134RPS6KC10.26054619
135STK100.24898751
136EPHA40.24731726
137PASK0.24268639
138FGFR40.23703720
139CAMK10.23186580
140PLK40.22932308
141HIPK20.22529614
142NTRK10.21823223
143RPS6KB20.21705771
144MAPK70.21040810
145ATM0.20504728
146CAMK2A0.19824788
147DAPK20.19806525
148MAP2K20.19801315
149YES10.18715713
150CCNB10.18687699
151PRKG20.16171972
152CDK60.15919572
153MKNK20.15130337
154CDK150.13950647
155GRK70.13625755
156CDK30.13004373
157ZAK0.12963180
158PLK20.12199664
159MAP2K40.12192986
160PLK10.11765772
161NEK60.11434898
162CDK180.11141797
163PKN10.11128114
164RPS6KB10.10980716
165GSK3B0.10680340
166MAPKAPK20.10669750
167PAK40.10331229
168PRKAA10.09880016
169MUSK0.08978518
170CLK10.08972908
171MAP3K20.08631488
172CAMK2B0.08081706
173TBK10.08073253
174DYRK1A0.06921662
175PRKCD0.06857640
176CDK11A0.06757730
177STK110.05634560

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.47340264
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.60512607
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.09500983
4Fatty acid biosynthesis_Homo sapiens_hsa000613.86624579
5Allograft rejection_Homo sapiens_hsa053303.31445704
6Graft-versus-host disease_Homo sapiens_hsa053323.30839086
7Autoimmune thyroid disease_Homo sapiens_hsa053203.20016127
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.87008758
9Sulfur relay system_Homo sapiens_hsa041222.85931432
10Linoleic acid metabolism_Homo sapiens_hsa005912.74450470
11Asthma_Homo sapiens_hsa053102.67005073
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58474404
13Vitamin B6 metabolism_Homo sapiens_hsa007502.55961974
14Type I diabetes mellitus_Homo sapiens_hsa049402.55478978
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.42450505
16Sulfur metabolism_Homo sapiens_hsa009202.36570901
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.31542190
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27139461
19Hematopoietic cell lineage_Homo sapiens_hsa046402.19962843
20Leishmaniasis_Homo sapiens_hsa051402.19221120
21Glycerolipid metabolism_Homo sapiens_hsa005612.12381624
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05418755
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.99784944
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99398377
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98990368
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.97672786
27Viral myocarditis_Homo sapiens_hsa054161.92722405
28Glucagon signaling pathway_Homo sapiens_hsa049221.90496673
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86142850
30Herpes simplex infection_Homo sapiens_hsa051681.83199127
31T cell receptor signaling pathway_Homo sapiens_hsa046601.81285509
32Selenocompound metabolism_Homo sapiens_hsa004501.80053648
33Pyruvate metabolism_Homo sapiens_hsa006201.79820252
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.78111037
35Chemical carcinogenesis_Homo sapiens_hsa052041.75821712
36Staphylococcus aureus infection_Homo sapiens_hsa051501.75679260
37Osteoclast differentiation_Homo sapiens_hsa043801.75201702
38Fructose and mannose metabolism_Homo sapiens_hsa000511.69583417
39Measles_Homo sapiens_hsa051621.68889548
40Base excision repair_Homo sapiens_hsa034101.64724929
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58251424
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58109044
43Collecting duct acid secretion_Homo sapiens_hsa049661.53235772
44DNA replication_Homo sapiens_hsa030301.52859906
45Amphetamine addiction_Homo sapiens_hsa050311.49722866
46Acute myeloid leukemia_Homo sapiens_hsa052211.47347232
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46758307
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.44457519
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.43130334
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41824908
51Mineral absorption_Homo sapiens_hsa049781.41361781
52Galactose metabolism_Homo sapiens_hsa000521.38583361
53Influenza A_Homo sapiens_hsa051641.35039101
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33686096
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33412795
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.32150585
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29987651
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28085804
59Basal transcription factors_Homo sapiens_hsa030221.27052455
60Tuberculosis_Homo sapiens_hsa051521.24116934
61Platelet activation_Homo sapiens_hsa046111.20338314
62Ether lipid metabolism_Homo sapiens_hsa005651.19729123
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18134418
64Glutathione metabolism_Homo sapiens_hsa004801.17885321
65PPAR signaling pathway_Homo sapiens_hsa033201.16191349
66Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14255699
67Toxoplasmosis_Homo sapiens_hsa051451.13338458
68Propanoate metabolism_Homo sapiens_hsa006401.13263342
69Epstein-Barr virus infection_Homo sapiens_hsa051691.11529062
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11477257
71Arachidonic acid metabolism_Homo sapiens_hsa005901.08461710
72Other glycan degradation_Homo sapiens_hsa005111.07988750
73Renin secretion_Homo sapiens_hsa049241.06401876
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06206751
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05643548
76Non-small cell lung cancer_Homo sapiens_hsa052231.04102248
77Butanoate metabolism_Homo sapiens_hsa006501.03893337
78Chemokine signaling pathway_Homo sapiens_hsa040621.02962402
79Systemic lupus erythematosus_Homo sapiens_hsa053221.02585205
80Hepatitis B_Homo sapiens_hsa051610.99028052
81Oocyte meiosis_Homo sapiens_hsa041140.98463438
82Dorso-ventral axis formation_Homo sapiens_hsa043200.95794806
83Viral carcinogenesis_Homo sapiens_hsa052030.94419805
84Pentose phosphate pathway_Homo sapiens_hsa000300.92483246
85Pancreatic cancer_Homo sapiens_hsa052120.87846243
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86476164
87Calcium signaling pathway_Homo sapiens_hsa040200.86032963
88Long-term potentiation_Homo sapiens_hsa047200.84212176
89Fanconi anemia pathway_Homo sapiens_hsa034600.83207683
90HTLV-I infection_Homo sapiens_hsa051660.81818933
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78092232
92Fatty acid degradation_Homo sapiens_hsa000710.77488198
93Fatty acid metabolism_Homo sapiens_hsa012120.76707703
94Rheumatoid arthritis_Homo sapiens_hsa053230.76674227
95Salivary secretion_Homo sapiens_hsa049700.76540908
96ABC transporters_Homo sapiens_hsa020100.75574154
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74922362
98Renin-angiotensin system_Homo sapiens_hsa046140.74031935
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.73298557
100Ribosome_Homo sapiens_hsa030100.73109559
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72879988
102VEGF signaling pathway_Homo sapiens_hsa043700.72698235
103Pyrimidine metabolism_Homo sapiens_hsa002400.71578863
104Shigellosis_Homo sapiens_hsa051310.71286768
105Apoptosis_Homo sapiens_hsa042100.70131460
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.69625881
107Bile secretion_Homo sapiens_hsa049760.69170014
108Glutamatergic synapse_Homo sapiens_hsa047240.68620281
109RNA polymerase_Homo sapiens_hsa030200.67020008
110Fat digestion and absorption_Homo sapiens_hsa049750.65474336
111Tight junction_Homo sapiens_hsa045300.65326379
112Gastric acid secretion_Homo sapiens_hsa049710.65303898
113Hepatitis C_Homo sapiens_hsa051600.64910753
114Chronic myeloid leukemia_Homo sapiens_hsa052200.63612297
115TNF signaling pathway_Homo sapiens_hsa046680.62446882
116Non-homologous end-joining_Homo sapiens_hsa034500.62041549
117Synaptic vesicle cycle_Homo sapiens_hsa047210.60972759
118Cardiac muscle contraction_Homo sapiens_hsa042600.60927982
119Spliceosome_Homo sapiens_hsa030400.60117653
120Estrogen signaling pathway_Homo sapiens_hsa049150.58783639
121Starch and sucrose metabolism_Homo sapiens_hsa005000.58085816
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57996209
123Malaria_Homo sapiens_hsa051440.56469958
124Insulin secretion_Homo sapiens_hsa049110.56303128
125Hedgehog signaling pathway_Homo sapiens_hsa043400.56289019
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55749172
127Pertussis_Homo sapiens_hsa051330.55017879
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.54306079
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53768460
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.53078162
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52535870
132Taste transduction_Homo sapiens_hsa047420.52503866
133cAMP signaling pathway_Homo sapiens_hsa040240.52283247
134Prolactin signaling pathway_Homo sapiens_hsa049170.51107936
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51000778
136Olfactory transduction_Homo sapiens_hsa047400.50964105
137Retinol metabolism_Homo sapiens_hsa008300.50947440
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50171806
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48372576
140Homologous recombination_Homo sapiens_hsa034400.48106709
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47970070
142Carbon metabolism_Homo sapiens_hsa012000.47330318
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.47255488
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.46160420
145Circadian entrainment_Homo sapiens_hsa047130.45640826
146Colorectal cancer_Homo sapiens_hsa052100.44797879
147Mismatch repair_Homo sapiens_hsa034300.44780003
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44360970
149Nucleotide excision repair_Homo sapiens_hsa034200.42410843
150Protein digestion and absorption_Homo sapiens_hsa049740.42320842
151Regulation of autophagy_Homo sapiens_hsa041400.42164094
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.41448175
153Pancreatic secretion_Homo sapiens_hsa049720.40969714
154RNA degradation_Homo sapiens_hsa030180.38528597
155African trypanosomiasis_Homo sapiens_hsa051430.38382557
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.36565702
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36282467
158Thyroid hormone synthesis_Homo sapiens_hsa049180.36185483
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.36074261
160Metabolic pathways_Homo sapiens_hsa011000.35587184
161mRNA surveillance pathway_Homo sapiens_hsa030150.35113258
162Dopaminergic synapse_Homo sapiens_hsa047280.34073994
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33817175
164Phototransduction_Homo sapiens_hsa047440.33575141
165Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33564745
166Inositol phosphate metabolism_Homo sapiens_hsa005620.32273475
167Nicotine addiction_Homo sapiens_hsa050330.32147013
168Phagosome_Homo sapiens_hsa041450.31919855
169Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31875128
170Legionellosis_Homo sapiens_hsa051340.31497418
171Purine metabolism_Homo sapiens_hsa002300.30379007
172Phospholipase D signaling pathway_Homo sapiens_hsa040720.30091572
173Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29546729
174Antigen processing and presentation_Homo sapiens_hsa046120.27239391
175Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26431237
176Alcoholism_Homo sapiens_hsa050340.25786164
177B cell receptor signaling pathway_Homo sapiens_hsa046620.24866602
178Axon guidance_Homo sapiens_hsa043600.23732034
179FoxO signaling pathway_Homo sapiens_hsa040680.21614944
180Choline metabolism in cancer_Homo sapiens_hsa052310.21359662
181Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18512299
182Small cell lung cancer_Homo sapiens_hsa052220.17096743
183Prostate cancer_Homo sapiens_hsa052150.15461150
184p53 signaling pathway_Homo sapiens_hsa041150.14751549

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