TTC19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.74505017
2vocalization behavior (GO:0071625)5.36278850
3synaptic vesicle exocytosis (GO:0016079)5.31239817
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20439790
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11859842
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.09249808
7synaptic vesicle maturation (GO:0016188)4.97274193
8regulation of glutamate receptor signaling pathway (GO:1900449)4.88723550
9glutamate secretion (GO:0014047)4.83156899
10regulation of synaptic vesicle exocytosis (GO:2000300)4.81937882
11locomotory exploration behavior (GO:0035641)4.81861533
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.81478135
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73353508
14protein localization to synapse (GO:0035418)4.57120707
15neuron cell-cell adhesion (GO:0007158)4.54784849
16neuronal action potential propagation (GO:0019227)4.48411335
17regulation of synaptic vesicle transport (GO:1902803)4.47861920
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.47489393
19respiratory chain complex IV assembly (GO:0008535)4.25032487
20neurotransmitter secretion (GO:0007269)4.22422117
21neuron-neuron synaptic transmission (GO:0007270)4.21613852
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.19605688
23synaptic transmission, glutamatergic (GO:0035249)4.16484198
24glutamate receptor signaling pathway (GO:0007215)4.14642863
25behavioral response to nicotine (GO:0035095)4.08555908
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08252086
27neurotransmitter-gated ion channel clustering (GO:0072578)4.05690075
28regulation of neuronal synaptic plasticity (GO:0048168)3.94559895
29exploration behavior (GO:0035640)3.89002302
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86638551
31response to pheromone (GO:0019236)3.82559199
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.73854424
33* cytochrome complex assembly (GO:0017004)3.73061125
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71671046
35gamma-aminobutyric acid transport (GO:0015812)3.70708069
36long-term synaptic potentiation (GO:0060291)3.65264131
37long-term memory (GO:0007616)3.63882044
38presynaptic membrane assembly (GO:0097105)3.62394222
39response to histamine (GO:0034776)3.61830257
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.61099091
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60072678
42postsynaptic membrane organization (GO:0001941)3.59371153
43regulation of postsynaptic membrane potential (GO:0060078)3.56122568
44regulation of synapse structural plasticity (GO:0051823)3.53001700
45* protein complex biogenesis (GO:0070271)3.50514207
46regulation of dendritic spine morphogenesis (GO:0061001)3.47178054
47positive regulation of membrane potential (GO:0045838)3.46795232
48regulation of neurotransmitter secretion (GO:0046928)3.46363363
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.44510711
50NADH dehydrogenase complex assembly (GO:0010257)3.44510711
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44510711
52transmission of nerve impulse (GO:0019226)3.43604877
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.43057432
54cerebellar Purkinje cell differentiation (GO:0021702)3.41634602
55regulation of synaptic plasticity (GO:0048167)3.41221780
56neurotransmitter transport (GO:0006836)3.40473703
57neuron recognition (GO:0008038)3.38954206
58water-soluble vitamin biosynthetic process (GO:0042364)3.37056699
59positive regulation of neurotransmitter secretion (GO:0001956)3.35384629
60synaptic vesicle endocytosis (GO:0048488)3.34740526
61positive regulation of synapse maturation (GO:0090129)3.34618381
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33984311
63tryptophan catabolic process (GO:0006569)3.32602897
64indole-containing compound catabolic process (GO:0042436)3.32602897
65indolalkylamine catabolic process (GO:0046218)3.32602897
66detection of calcium ion (GO:0005513)3.30712027
67indolalkylamine metabolic process (GO:0006586)3.29610226
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.29302571
69kynurenine metabolic process (GO:0070189)3.29161003
70proline transport (GO:0015824)3.28397700
71positive regulation of neurotransmitter transport (GO:0051590)3.27339362
72startle response (GO:0001964)3.25664810
73dendritic spine morphogenesis (GO:0060997)3.24045516
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23760200
75striatum development (GO:0021756)3.21935510
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20360031
77regulation of neurotransmitter transport (GO:0051588)3.17854795
78regulation of glutamate secretion (GO:0014048)3.17054211
79presynaptic membrane organization (GO:0097090)3.16986893
80layer formation in cerebral cortex (GO:0021819)3.16842549
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16186997
82replication fork processing (GO:0031297)3.15947521
83cellular potassium ion homeostasis (GO:0030007)3.15785689
84* mitochondrial respiratory chain complex assembly (GO:0033108)3.14874465
85axonal fasciculation (GO:0007413)3.14721392
86membrane depolarization during action potential (GO:0086010)3.11752515
87regulation of neurotransmitter levels (GO:0001505)3.10142378
88activation of protein kinase A activity (GO:0034199)3.09498182
89negative regulation of dendrite morphogenesis (GO:0050774)3.08716969
90membrane depolarization (GO:0051899)3.07485743
91learning (GO:0007612)3.07200762
92kidney morphogenesis (GO:0060993)3.06672977
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05679566
94otic vesicle formation (GO:0030916)3.04650854
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03724923
96behavioral fear response (GO:0001662)3.03569626
97behavioral defense response (GO:0002209)3.03569626
98regulation of vesicle fusion (GO:0031338)3.02503806
99negative regulation of dendrite development (GO:2000171)3.01676728
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00811544
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00506398
102tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00506398
103regulation of female receptivity (GO:0045924)3.00360736
104innervation (GO:0060384)2.99673773
105regulation of synaptic transmission, GABAergic (GO:0032228)2.98444085
106positive regulation of synaptic transmission (GO:0050806)2.98074457
107cell communication by electrical coupling (GO:0010644)2.97918027
108regulation of dendritic spine development (GO:0060998)2.97763764
109synaptic transmission (GO:0007268)2.97679288
110long term synaptic depression (GO:0060292)2.97620378
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97455358
112regulation of synapse maturation (GO:0090128)2.97401478
113behavioral response to cocaine (GO:0048148)2.96753395
114auditory behavior (GO:0031223)2.96284437
115DNA double-strand break processing (GO:0000729)2.95949354
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95242251
117tryptophan metabolic process (GO:0006568)2.95046607
118response to auditory stimulus (GO:0010996)2.93726105
119regulation of voltage-gated calcium channel activity (GO:1901385)2.92272128
120positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91722599
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87732618
122synapse assembly (GO:0007416)2.87664350
123ATP synthesis coupled proton transport (GO:0015986)2.87505817
124energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87505817
125membrane hyperpolarization (GO:0060081)2.87179207
126cerebellar granule cell differentiation (GO:0021707)2.85935199
127regulation of synaptic transmission (GO:0050804)2.85912709
128pyrimidine nucleobase catabolic process (GO:0006208)2.81654431
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80293768
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74742637
131retinal cone cell development (GO:0046549)2.73280778
132intraciliary transport (GO:0042073)2.72814141
133negative regulation of DNA-dependent DNA replication (GO:2000104)2.72687651
134DNA deamination (GO:0045006)2.72097896
135piRNA metabolic process (GO:0034587)2.68726203
136axoneme assembly (GO:0035082)2.63754133
137fucose catabolic process (GO:0019317)2.60471589
138L-fucose metabolic process (GO:0042354)2.60471589
139L-fucose catabolic process (GO:0042355)2.60471589
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59946403
141regulation of hexokinase activity (GO:1903299)2.59124094
142regulation of glucokinase activity (GO:0033131)2.59124094
143indole-containing compound metabolic process (GO:0042430)2.58758635
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58177950
145protein polyglutamylation (GO:0018095)2.58169767
146prenylation (GO:0097354)2.57855580
147protein prenylation (GO:0018342)2.57855580
148maturation of 5.8S rRNA (GO:0000460)2.56986205
149recombinational repair (GO:0000725)2.55996801
150protein neddylation (GO:0045116)2.55511597
151double-strand break repair via homologous recombination (GO:0000724)2.54578035
152DNA integration (GO:0015074)2.53957338
153epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53823775
154regulation of cilium movement (GO:0003352)2.53612829
155detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52547651
156respiratory electron transport chain (GO:0022904)2.50727878
157regulation of non-canonical Wnt signaling pathway (GO:2000050)2.50522815
158electron transport chain (GO:0022900)2.50131274
159termination of RNA polymerase III transcription (GO:0006386)2.48962855
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.48962855
161maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46710140
162regulation of mitochondrial translation (GO:0070129)2.46593307
163pseudouridine synthesis (GO:0001522)2.46173439
164double-strand break repair via nonhomologous end joining (GO:0006303)2.45001648
165non-recombinational repair (GO:0000726)2.45001648
166nucleobase catabolic process (GO:0046113)2.44958406
167monoubiquitinated protein deubiquitination (GO:0035520)2.44499358
168reciprocal meiotic recombination (GO:0007131)2.44416238
169reciprocal DNA recombination (GO:0035825)2.44416238
170epithelial cilium movement (GO:0003351)2.42300273
171resolution of meiotic recombination intermediates (GO:0000712)2.41868577
172intracellular protein transmembrane import (GO:0044743)2.41000872
173regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40838983
174regulation of mitotic spindle checkpoint (GO:1903504)2.40838983
175seminiferous tubule development (GO:0072520)2.40235067
176protein-cofactor linkage (GO:0018065)2.39918203
177nonmotile primary cilium assembly (GO:0035058)2.38633819
178pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.37648381
179positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.36564833
180negative regulation of membrane potential (GO:0045837)2.36328899
181chromatin remodeling at centromere (GO:0031055)2.34240183
182photoreceptor cell maintenance (GO:0045494)2.32274358
183branched-chain amino acid catabolic process (GO:0009083)2.30315774
184histone exchange (GO:0043486)2.29740247
185cellular ketone body metabolic process (GO:0046950)2.29216049
186negative regulation of transcription regulatory region DNA binding (GO:2000678)2.29102631
187somite development (GO:0061053)2.28904141
188synapsis (GO:0007129)2.28651715
189lysine catabolic process (GO:0006554)2.28520049
190lysine metabolic process (GO:0006553)2.28520049
191limb bud formation (GO:0060174)2.26551024
192detection of light stimulus involved in sensory perception (GO:0050962)2.25278775
193detection of light stimulus involved in visual perception (GO:0050908)2.25278775
194cilium morphogenesis (GO:0060271)2.25018837
195male meiosis (GO:0007140)2.24715548
196behavioral response to ethanol (GO:0048149)2.23938300
197base-excision repair, AP site formation (GO:0006285)2.22625874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59040031
2GBX2_23144817_ChIP-Seq_PC3_Human4.35454895
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47320432
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92996724
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.84751989
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80707038
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75212605
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45265616
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44846201
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42045018
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42008665
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42008665
13REST_21632747_ChIP-Seq_MESCs_Mouse2.39141398
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38843926
15EWS_26573619_Chip-Seq_HEK293_Human2.37224106
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34012387
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.32878743
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32170291
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28508796
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.28380464
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25440732
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25095577
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24919945
24TAF15_26573619_Chip-Seq_HEK293_Human2.23130325
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21646181
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18405911
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.16833654
28DROSHA_22980978_ChIP-Seq_HELA_Human2.10788871
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.05638281
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02430860
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00183034
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98988837
33SMAD4_21799915_ChIP-Seq_A2780_Human1.96492633
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.96033437
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95753776
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94304785
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.89891101
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.89203426
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87806687
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87329978
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81215225
42P300_19829295_ChIP-Seq_ESCs_Human1.77850939
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69257612
44AR_21572438_ChIP-Seq_LNCaP_Human1.68063552
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.67836038
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67790966
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61052165
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60754188
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55936373
50MYC_18940864_ChIP-ChIP_HL60_Human1.54355295
51FUS_26573619_Chip-Seq_HEK293_Human1.53636479
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52308926
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49828460
54CBP_20019798_ChIP-Seq_JUKART_Human1.49491826
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49491826
56ELK1_19687146_ChIP-ChIP_HELA_Human1.49110574
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47027321
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.46248797
59STAT3_23295773_ChIP-Seq_U87_Human1.46231491
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.45752565
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44301387
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.43508177
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43137404
64ZNF274_21170338_ChIP-Seq_K562_Hela1.42683259
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42432717
66AR_25329375_ChIP-Seq_VCAP_Human1.42343869
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40638389
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39642510
69VDR_23849224_ChIP-Seq_CD4+_Human1.38769751
70IRF1_19129219_ChIP-ChIP_H3396_Human1.38622507
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38612813
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.35315772
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32384361
74TCF4_23295773_ChIP-Seq_U87_Human1.31924435
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31830629
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30755368
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30301047
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.30125560
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29912455
80TP53_22573176_ChIP-Seq_HFKS_Human1.29328968
81IGF1R_20145208_ChIP-Seq_DFB_Human1.26103102
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25901174
83SOX2_19829295_ChIP-Seq_ESCs_Human1.24297964
84NANOG_19829295_ChIP-Seq_ESCs_Human1.24297964
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22644216
86AR_19668381_ChIP-Seq_PC3_Human1.22315052
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22037527
88RNF2_27304074_Chip-Seq_NSC_Mouse1.21920813
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21600338
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19689946
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19642275
92TCF4_22108803_ChIP-Seq_LS180_Human1.19633103
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18746230
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18626081
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18401780
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18347646
97ER_23166858_ChIP-Seq_MCF-7_Human1.18320848
98TP53_16413492_ChIP-PET_HCT116_Human1.17828982
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17584958
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.17151628
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16746657
102ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16045392
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14813792
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.14571112
105BCAT_22108803_ChIP-Seq_LS180_Human1.14367534
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13368281
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.13368281
108RUNX2_22187159_ChIP-Seq_PCA_Human1.12503451
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12500395
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12425045
111JUN_21703547_ChIP-Seq_K562_Human1.11435678
112E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11420279
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.11242991
114TP53_18474530_ChIP-ChIP_U2OS_Human1.11221427
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09497890
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09256608
117AHR_22903824_ChIP-Seq_MCF-7_Human1.08529020
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07379900
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06856366
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06819058
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.05390321
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05384543
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04933068
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04815565
125FLI1_27457419_Chip-Seq_LIVER_Mouse1.04542157
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04462498
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.03598827
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03463850
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.03404383
130SRF_21415370_ChIP-Seq_HL-1_Mouse1.02809601
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02590571
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02590571
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02392222
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.01969453
135FOXP3_21729870_ChIP-Seq_TREG_Human1.01042097
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00986820
137P53_22387025_ChIP-Seq_ESCs_Mouse1.00514658
138NCOR_22424771_ChIP-Seq_293T_Human1.00273039
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99932593
140* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99891885
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98775026
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98416942
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.97999935
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97883311
145RXR_22108803_ChIP-Seq_LS180_Human0.97806583
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97738602
147VDR_22108803_ChIP-Seq_LS180_Human0.97440669
148P300_18555785_Chip-Seq_ESCs_Mouse0.96919402
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96513003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.93156567
2MP0003880_abnormal_central_pattern4.92724759
3MP0003635_abnormal_synaptic_transmissio3.98570960
4MP0004270_analgesia3.51922238
5MP0009745_abnormal_behavioral_response3.43961385
6MP0002063_abnormal_learning/memory/cond3.29384569
7MP0009046_muscle_twitch3.15204901
8MP0008877_abnormal_DNA_methylation3.08560729
9MP0002064_seizures3.01716175
10MP0002822_catalepsy2.89855797
11MP0001968_abnormal_touch/_nociception2.87341953
12MP0002572_abnormal_emotion/affect_behav2.77529194
13MP0002272_abnormal_nervous_system2.55722693
14MP0001486_abnormal_startle_reflex2.53685420
15MP0006292_abnormal_olfactory_placode2.50935332
16MP0002734_abnormal_mechanical_nocicepti2.49829941
17MP0001501_abnormal_sleep_pattern2.48949174
18MP0005423_abnormal_somatic_nervous2.48641228
19MP0009780_abnormal_chondrocyte_physiolo2.36545642
20MP0005646_abnormal_pituitary_gland2.28136676
21MP0002735_abnormal_chemical_nociception2.23431558
22MP0002736_abnormal_nociception_after2.16399636
23MP0006072_abnormal_retinal_apoptosis2.08545040
24MP0001440_abnormal_grooming_behavior2.08483779
25MP0008058_abnormal_DNA_repair1.95077759
26MP0001188_hyperpigmentation1.93661305
27MP0002067_abnormal_sensory_capabilities1.93187593
28MP0008875_abnormal_xenobiotic_pharmacok1.85252842
29MP0009379_abnormal_foot_pigmentation1.84936289
30MP0002102_abnormal_ear_morphology1.84771208
31MP0004924_abnormal_behavior1.83014016
32MP0005386_behavior/neurological_phenoty1.83014016
33MP0002938_white_spotting1.82341946
34MP0002837_dystrophic_cardiac_calcinosis1.77694615
35MP0002557_abnormal_social/conspecific_i1.73230271
36MP0003787_abnormal_imprinting1.71478085
37MP0006276_abnormal_autonomic_nervous1.70317129
38MP0002184_abnormal_innervation1.70009990
39MP0001970_abnormal_pain_threshold1.67891347
40MP0002733_abnormal_thermal_nociception1.66954310
41MP0008569_lethality_at_weaning1.66281840
42MP0000778_abnormal_nervous_system1.59550106
43MP0001984_abnormal_olfaction1.57621394
44MP0005645_abnormal_hypothalamus_physiol1.56635546
45MP0000751_myopathy1.54231714
46MP0002909_abnormal_adrenal_gland1.53185075
47MP0003122_maternal_imprinting1.52928214
48MP0003718_maternal_effect1.52908150
49MP0004145_abnormal_muscle_electrophysio1.49583158
50MP0004811_abnormal_neuron_physiology1.48361270
51MP0003879_abnormal_hair_cell1.47672863
52MP0005253_abnormal_eye_physiology1.46826692
53MP0003011_delayed_dark_adaptation1.46330541
54MP0008995_early_reproductive_senescence1.43669499
55MP0004147_increased_porphyrin_level1.40030376
56MP0010386_abnormal_urinary_bladder1.36424598
57MP0001502_abnormal_circadian_rhythm1.31570564
58MP0000955_abnormal_spinal_cord1.31410103
59MP0004215_abnormal_myocardial_fiber1.30153961
60MP0001529_abnormal_vocalization1.30108212
61MP0002066_abnormal_motor_capabilities/c1.28541427
62MP0004133_heterotaxia1.28033040
63MP0002882_abnormal_neuron_morphology1.26020305
64MP0003195_calcinosis1.25118295
65MP0002160_abnormal_reproductive_system1.25062572
66MP0003646_muscle_fatigue1.23325020
67MP0004484_altered_response_of1.21701346
68MP0005551_abnormal_eye_electrophysiolog1.21086957
69MP0000569_abnormal_digit_pigmentation1.20373732
70MP0004142_abnormal_muscle_tone1.16144603
71MP0003937_abnormal_limbs/digits/tail_de1.15412881
72MP0003136_yellow_coat_color1.13821906
73MP0004858_abnormal_nervous_system1.11508555
74MP0002751_abnormal_autonomic_nervous1.11082037
75MP0003890_abnormal_embryonic-extraembry1.09066299
76MP0002638_abnormal_pupillary_reflex1.08624028
77MP0003633_abnormal_nervous_system1.07663821
78MP0008775_abnormal_heart_ventricle1.06640199
79MP0001986_abnormal_taste_sensitivity1.06607107
80MP0004085_abnormal_heartbeat1.05773012
81MP0002234_abnormal_pharynx_morphology1.05406520
82MP0001293_anophthalmia1.04718967
83MP0000566_synostosis1.03027566
84MP0005389_reproductive_system_phenotype1.02117638
85MP0001905_abnormal_dopamine_level1.01121004
86MP0000427_abnormal_hair_cycle0.99809989
87MP0002876_abnormal_thyroid_physiology0.99504941
88MP0005535_abnormal_body_temperature0.99222703
89MP0008789_abnormal_olfactory_epithelium0.98274913
90MP0002152_abnormal_brain_morphology0.94091359
91MP0010094_abnormal_chromosome_stability0.93926186
92MP0005174_abnormal_tail_pigmentation0.93640862
93MP0003119_abnormal_digestive_system0.93061487
94MP0003567_abnormal_fetal_cardiomyocyte0.91915311
95MP0002210_abnormal_sex_determination0.91423959
96MP0005367_renal/urinary_system_phenotyp0.91397422
97MP0000516_abnormal_urinary_system0.91397422
98MP0003329_amyloid_beta_deposits0.90176935
99MP0002229_neurodegeneration0.90059011
100MP0000631_abnormal_neuroendocrine_gland0.89652583
101MP0003137_abnormal_impulse_conducting0.88665219
102MP0003631_nervous_system_phenotype0.87421273
103MP0001929_abnormal_gametogenesis0.87268381
104MP0000383_abnormal_hair_follicle0.87132972
105MP0003698_abnormal_male_reproductive0.87052657
106MP0001177_atelectasis0.86620573
107MP0000653_abnormal_sex_gland0.86402690
108MP0002069_abnormal_eating/drinking_beha0.85957613
109MP0004885_abnormal_endolymph0.85920407
110MP0000372_irregular_coat_pigmentation0.85716559
111MP0001145_abnormal_male_reproductive0.84514373
112MP0005620_abnormal_muscle_contractility0.83785187
113MP0001919_abnormal_reproductive_system0.83055103
114MP0008874_decreased_physiological_sensi0.81332541
115MP0004233_abnormal_muscle_weight0.80432409
116MP0001963_abnormal_hearing_physiology0.79667730
117MP0005195_abnormal_posterior_eye0.79621354
118MP0004130_abnormal_muscle_cell0.79367620
119MP0005409_darkened_coat_color0.79317373
120MP0003123_paternal_imprinting0.79256155
121MP0005332_abnormal_amino_acid0.79209818
122MP0004036_abnormal_muscle_relaxation0.76344858
123MP0000749_muscle_degeneration0.73695160
124MP0000013_abnormal_adipose_tissue0.71633976
125MP0004510_myositis0.69214012
126MP0004043_abnormal_pH_regulation0.68359140
127MP0008872_abnormal_physiological_respon0.67671803
128MP0002752_abnormal_somatic_nervous0.64943737
129MP0002090_abnormal_vision0.64703818
130MP0002972_abnormal_cardiac_muscle0.63813322
131MP0005171_absent_coat_pigmentation0.62008908
132MP0003283_abnormal_digestive_organ0.59889825
133MP0004742_abnormal_vestibular_system0.58978753
134MP0001485_abnormal_pinna_reflex0.56199093
135MP0008961_abnormal_basal_metabolism0.56144488
136MP0003121_genomic_imprinting0.55065431
137MP0009697_abnormal_copulation0.54721074
138MP0005499_abnormal_olfactory_system0.54470023
139MP0005394_taste/olfaction_phenotype0.54470023
140MP0001943_abnormal_respiration0.53139380
141MP0001299_abnormal_eye_distance/0.52891566
142MP0000747_muscle_weakness0.52305331
143MP0003632_abnormal_nervous_system0.50740608
144MP0001664_abnormal_digestion0.49407334
145MP0010770_preweaning_lethality0.48944488

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.64633103
2Focal seizures (HP:0007359)5.81070006
3Febrile seizures (HP:0002373)5.76268743
4Myokymia (HP:0002411)5.69169411
5Epileptic encephalopathy (HP:0200134)5.44905345
6Atonic seizures (HP:0010819)5.33407405
7Absence seizures (HP:0002121)4.67753569
8Visual hallucinations (HP:0002367)4.49590381
9Progressive cerebellar ataxia (HP:0002073)4.39119098
10Generalized tonic-clonic seizures (HP:0002069)4.24752752
11Hyperventilation (HP:0002883)4.22776619
12Dialeptic seizures (HP:0011146)4.20453344
13Broad-based gait (HP:0002136)3.91953179
14Gaze-evoked nystagmus (HP:0000640)3.76662451
15Pancreatic fibrosis (HP:0100732)3.52178872
16Pancreatic cysts (HP:0001737)3.41136309
17Nephronophthisis (HP:0000090)3.30811451
18Molar tooth sign on MRI (HP:0002419)3.29421614
19Abnormality of midbrain morphology (HP:0002418)3.29421614
20Poor eye contact (HP:0000817)3.27043983
21Hepatocellular necrosis (HP:0001404)3.18605506
22Impaired vibration sensation in the lower limbs (HP:0002166)3.10608447
23True hermaphroditism (HP:0010459)3.10450197
24Action tremor (HP:0002345)3.09164528
25Drooling (HP:0002307)3.08204605
26Excessive salivation (HP:0003781)3.08204605
27Impaired social interactions (HP:0000735)3.01009342
28Abnormal social behavior (HP:0012433)3.01009342
29Amblyopia (HP:0000646)2.95648308
30Dysmetric saccades (HP:0000641)2.93713533
31Mitochondrial inheritance (HP:0001427)2.89261748
32Depression (HP:0000716)2.89087664
33Abnormality of the renal medulla (HP:0100957)2.88104818
34* Dysdiadochokinesis (HP:0002075)2.87766704
35Truncal ataxia (HP:0002078)2.86539111
36Acute necrotizing encephalopathy (HP:0006965)2.83752796
37Genetic anticipation (HP:0003743)2.83418198
38Hepatic necrosis (HP:0002605)2.82687514
39Epileptiform EEG discharges (HP:0011182)2.82463782
40Medial flaring of the eyebrow (HP:0010747)2.77645415
41Protruding tongue (HP:0010808)2.75436077
42Postural instability (HP:0002172)2.75321534
43Absent speech (HP:0001344)2.71093168
44Urinary bladder sphincter dysfunction (HP:0002839)2.70910521
45Progressive macrocephaly (HP:0004481)2.68530415
46Increased CSF lactate (HP:0002490)2.67927223
47Pheochromocytoma (HP:0002666)2.67720539
48Abnormality of the renal cortex (HP:0011035)2.65685642
49EEG with generalized epileptiform discharges (HP:0011198)2.63960220
50Scanning speech (HP:0002168)2.62002857
51* Anxiety (HP:0000739)2.60873300
52Progressive inability to walk (HP:0002505)2.59831983
53Type II lissencephaly (HP:0007260)2.59267953
54* Dysmetria (HP:0001310)2.56489814
55Abnormal hair whorl (HP:0010721)2.52717641
56Fetal akinesia sequence (HP:0001989)2.50309912
57Increased hepatocellular lipid droplets (HP:0006565)2.49927228
58Impaired smooth pursuit (HP:0007772)2.49637017
59Congenital stationary night blindness (HP:0007642)2.47217560
60Abnormal mitochondria in muscle tissue (HP:0008316)2.47206638
61Abnormal eating behavior (HP:0100738)2.46627123
62Acute encephalopathy (HP:0006846)2.45949095
63Neoplasm of the adrenal cortex (HP:0100641)2.45695971
64Inability to walk (HP:0002540)2.44610810
65Lipid accumulation in hepatocytes (HP:0006561)2.43230681
66Hypsarrhythmia (HP:0002521)2.42796580
67Hyperglycinemia (HP:0002154)2.40778696
68Blue irides (HP:0000635)2.40629555
69Septo-optic dysplasia (HP:0100842)2.40620691
70Exercise-induced myalgia (HP:0003738)2.39971358
71Impaired vibratory sensation (HP:0002495)2.39421209
72Ankle clonus (HP:0011448)2.39048116
73Colon cancer (HP:0003003)2.37370096
74Neuroendocrine neoplasm (HP:0100634)2.33878664
75Stereotypic behavior (HP:0000733)2.31424105
76Status epilepticus (HP:0002133)2.31134415
77Renal cortical cysts (HP:0000803)2.29533383
78Hypothermia (HP:0002045)2.25022220
79Abnormality of salivation (HP:0100755)2.23338245
80Optic nerve hypoplasia (HP:0000609)2.22377501
81Chronic hepatic failure (HP:0100626)2.19868165
82Cystic liver disease (HP:0006706)2.19857459
83Congenital, generalized hypertrichosis (HP:0004540)2.18652377
84Methylmalonic acidemia (HP:0002912)2.16728641
85Congenital primary aphakia (HP:0007707)2.16118573
86Abnormality of ocular smooth pursuit (HP:0000617)2.14558757
87* Bradykinesia (HP:0002067)2.13308212
88Hemiparesis (HP:0001269)2.13277353
89Abnormal rod and cone electroretinograms (HP:0008323)2.11825961
90Sclerocornea (HP:0000647)2.09237974
91Cerebral edema (HP:0002181)2.09225401
92Abnormality of binocular vision (HP:0011514)2.08939582
93Diplopia (HP:0000651)2.08939582
94Prolonged QT interval (HP:0001657)2.08823839
95Intestinal atresia (HP:0011100)2.08207200
96Abnormal EKG (HP:0003115)2.08084509
97Bile duct proliferation (HP:0001408)2.07383689
98Abnormal biliary tract physiology (HP:0012439)2.07383689
99Abolished electroretinogram (ERG) (HP:0000550)2.07370139
100Fair hair (HP:0002286)2.06803428
101Generalized hypopigmentation of hair (HP:0011358)2.06605301
102Hypoplasia of the pons (HP:0012110)2.05227201
103Urinary urgency (HP:0000012)2.05155089
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04875655
105Genital tract atresia (HP:0001827)2.03917592
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03906673
107Torticollis (HP:0000473)2.03486279
108Incomplete penetrance (HP:0003829)2.02651271
109Abnormality of the pons (HP:0007361)2.01224308
110Central scotoma (HP:0000603)2.00904389
111Hyperglycinuria (HP:0003108)2.00276630
112Vaginal atresia (HP:0000148)1.99480022
113Nephrogenic diabetes insipidus (HP:0009806)1.99373153
114Optic disc pallor (HP:0000543)1.98657251
115Abnormality of glycine metabolism (HP:0010895)1.97106932
116Abnormality of serine family amino acid metabolism (HP:0010894)1.97106932
117Abnormality of alanine metabolism (HP:0010916)1.96616600
118Hyperalaninemia (HP:0003348)1.96616600
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96616600
120Sudden death (HP:0001699)1.96313507
121Decreased central vision (HP:0007663)1.96051545
122Attenuation of retinal blood vessels (HP:0007843)1.96022578
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.95258521
124Polyphagia (HP:0002591)1.95240084
125Stomach cancer (HP:0012126)1.95191682
126Supranuclear gaze palsy (HP:0000605)1.94161707
127Focal dystonia (HP:0004373)1.92367554
128Generalized myoclonic seizures (HP:0002123)1.91759131
129Mutism (HP:0002300)1.91739776
130Volvulus (HP:0002580)1.91319536
131Lower limb amyotrophy (HP:0007210)1.90928957
132Abnormality of the labia minora (HP:0012880)1.89854864
133Anencephaly (HP:0002323)1.89577425
134Asplenia (HP:0001746)1.89329688
135Cutaneous melanoma (HP:0012056)1.88647495
136Stenosis of the external auditory canal (HP:0000402)1.88161013
137Ventricular fibrillation (HP:0001663)1.86709371
138Syncope (HP:0001279)1.85312260
139Abnormality of the lower motor neuron (HP:0002366)1.84931923
1403-Methylglutaconic aciduria (HP:0003535)1.82904307
141Renal Fanconi syndrome (HP:0001994)1.82722290
142Methylmalonic aciduria (HP:0012120)1.82011236
143Atrial fibrillation (HP:0005110)1.80798318
144Primary atrial arrhythmia (HP:0001692)1.79825138
145Papilledema (HP:0001085)1.79744747
146Cerebellar dysplasia (HP:0007033)1.79179388
147Male pseudohermaphroditism (HP:0000037)1.78882001
148Pendular nystagmus (HP:0012043)1.78649902
149Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77744658
150Resting tremor (HP:0002322)1.77458602
151Gait ataxia (HP:0002066)1.77209931
152Hypoplasia of the uterus (HP:0000013)1.76840052
153Tubular atrophy (HP:0000092)1.76786302
154Spinal canal stenosis (HP:0003416)1.76213376
155Gastrointestinal atresia (HP:0002589)1.75601412
156Congenital hepatic fibrosis (HP:0002612)1.75383552
157Lower limb muscle weakness (HP:0007340)1.75241159
158Tachypnea (HP:0002789)1.75058761
159Abnormality of the calf musculature (HP:0001430)1.74891102
160Abnormality of serum amino acid levels (HP:0003112)1.74445491
161Lissencephaly (HP:0001339)1.74339893
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.74294675
163Tubulointerstitial nephritis (HP:0001970)1.74269635
164Hyperthyroidism (HP:0000836)1.74069476
165Concave nail (HP:0001598)1.73543014
166Lethargy (HP:0001254)1.72634259
167Aplasia/hypoplasia of the uterus (HP:0008684)1.72517961
168Neoplasm of the adrenal gland (HP:0100631)1.71910425
169Abnormality of urine glucose concentration (HP:0011016)1.70880260
170Glycosuria (HP:0003076)1.70880260
171Abnormal pancreas size (HP:0012094)1.70865644
172Spastic gait (HP:0002064)1.70644647
173Increased serum lactate (HP:0002151)1.69969789
174Keratoconus (HP:0000563)1.68622502
175Increased corneal curvature (HP:0100692)1.68622502
176Bundle branch block (HP:0011710)1.67844054
177Polydipsia (HP:0001959)1.67405190
178Abnormal drinking behavior (HP:0030082)1.67405190
179Thickened helices (HP:0000391)1.67147817
180Agitation (HP:0000713)1.66861102
181Hemiplegia (HP:0002301)1.66042500
182Horizontal nystagmus (HP:0000666)1.64509393
183Insidious onset (HP:0003587)1.63869421
184Termporal pattern (HP:0011008)1.63869421
185Craniofacial dystonia (HP:0012179)1.63662353
186Limb dystonia (HP:0002451)1.63267559
187Supraventricular tachycardia (HP:0004755)1.62793296
188Gait imbalance (HP:0002141)1.62148516
189Exotropia (HP:0000577)1.61966625
190Failure to thrive in infancy (HP:0001531)1.61895651
191Muscle hypertrophy of the lower extremities (HP:0008968)1.61637553
192Neoplasm of the peripheral nervous system (HP:0100007)1.61405923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.39105817
2EPHA44.37721261
3CASK3.22223268
4MAP3K43.18370666
5BMPR1B3.18074855
6MAP2K73.16303847
7MAP3K92.83322336
8MARK12.64998475
9MINK12.50186459
10NUAK12.39919702
11RIPK42.28176071
12DAPK22.24352620
13MAP3K122.22543307
14GRK12.18791169
15ACVR1B2.18268127
16ZAK2.13593035
17FGFR22.08881251
18MAP2K42.08825791
19MAP4K22.03825284
20PRPF4B1.97077822
21AKT31.86508777
22PLK21.80108773
23KSR11.77985063
24CDK191.70235550
25PAK61.66810615
26ADRBK21.65739432
27SGK21.64386682
28MKNK11.58477056
29DAPK11.58322686
30SIK31.53295948
31SIK21.52259792
32EIF2AK31.50764256
33STK391.47718091
34BMPR21.47187881
35TNIK1.45264510
36NTRK21.45092744
37WNK41.43722827
38CDC71.40984045
39KSR21.40092829
40CAMKK11.33964673
41TAOK31.32250300
42SGK2231.32129215
43SGK4941.32129215
44BRSK21.31257554
45PLK31.30708892
46CDK51.30007179
47PRKD31.28504053
48PINK11.27609660
49PRKCG1.26730197
50MAPK131.26027078
51STK161.25748903
52PNCK1.24456151
53STK38L1.22681103
54VRK21.21621592
55SGK31.21058785
56NME11.19910249
57PHKG11.15171994
58PHKG21.15171994
59GRK51.13639489
60MST41.12687148
61TRIM281.12446863
62DYRK21.11517713
63CAMK2A1.10737396
64BCKDK1.08578712
65STK381.05651495
66MAP3K131.05367967
67CSNK1G11.04031009
68CSNK1G21.03958977
69NTRK10.98950408
70TAF10.98422333
71PLK40.94502972
72TGFBR10.92645001
73CAMKK20.91541600
74SRPK10.89731139
75FES0.89629529
76ARAF0.89043993
77PASK0.87096218
78SGK10.86240715
79TSSK60.86063347
80PLK10.83495167
81TXK0.83082382
82CAMK10.82978139
83CSNK1G30.82151321
84WEE10.81452428
85PTK2B0.78965914
86CCNB10.77174816
87ATR0.76990397
88MAP3K20.72850913
89RAF10.72797705
90DYRK1A0.71880604
91PRKCE0.70957588
92VRK10.70578157
93WNK30.70139010
94STK110.68853099
95CAMK2B0.68618086
96PAK30.67525239
97TNK20.66498327
98FRK0.66279501
99TLK10.66002989
100CSNK1A1L0.63393846
101NEK10.62053338
102MAP3K60.61141752
103BRAF0.61111813
104PRKCH0.60201808
105ATM0.58305731
106PDK10.58193652
107OBSCN0.58011864
108INSRR0.57786990
109CAMK2D0.57002856
110OXSR10.56337459
111ERBB30.55671225
112ADRBK10.55617128
113PDK20.55321741
114CDK180.55073954
115LATS20.54474145
116UHMK10.54276477
117MUSK0.54087411
118PDPK10.53326454
119BRD40.52523394
120RET0.51658260
121GRK70.51147093
122BCR0.49430237
123CSNK1A10.49308050
124MAP3K10.49194201
125PDK40.47674959
126PDK30.47674959
127CSNK1D0.47329775
128FER0.47201870
129TIE10.47004744
130CHEK20.46807845
131CDK150.46742109
132RPS6KA30.46606211
133PRKACA0.45612657
134MKNK20.45318558
135TEC0.44932092
136EIF2AK10.44545472
137CDK140.44373957
138CAMK1G0.44287402
139PRKCI0.44121943
140STK30.43626128
141CAMK40.43356001
142CDC42BPA0.43269975
143CSNK1E0.42618118
144NEK60.42223892
145PRKCQ0.41517068
146PKN10.40881258
147PRKDC0.40613554
148CDK11A0.40078803
149MAPKAPK50.40059172
150MAPK100.39771689
151MAPK120.39732171
152MAP2K10.39661507
153PRKCZ0.39100013
154STK240.38685326
155PIK3CA0.38670234
156RPS6KA50.38537707
157MAP3K70.38456389
158CDK30.36874111
159CAMK2G0.36635361
160FLT30.36192321
161PRKCA0.35792372
162CSNK2A20.35523173
163DMPK0.35349599
164RPS6KB10.34892684
165DYRK30.32493778
166TTK0.31664136

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93062281
2Caffeine metabolism_Homo sapiens_hsa002323.72642302
3Synaptic vesicle cycle_Homo sapiens_hsa047213.23699702
4Olfactory transduction_Homo sapiens_hsa047402.80200237
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80129937
6Long-term potentiation_Homo sapiens_hsa047202.78618003
7GABAergic synapse_Homo sapiens_hsa047272.73301216
8Circadian entrainment_Homo sapiens_hsa047132.72861045
9Morphine addiction_Homo sapiens_hsa050322.64238110
10Amphetamine addiction_Homo sapiens_hsa050312.49938931
11Glutamatergic synapse_Homo sapiens_hsa047242.47238623
12Protein export_Homo sapiens_hsa030602.34470782
13RNA polymerase_Homo sapiens_hsa030202.31211108
14Dopaminergic synapse_Homo sapiens_hsa047282.13359108
15Insulin secretion_Homo sapiens_hsa049112.11495046
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07607012
17Salivary secretion_Homo sapiens_hsa049702.05357053
18Taste transduction_Homo sapiens_hsa047421.99393536
19Homologous recombination_Homo sapiens_hsa034401.93367224
20Ribosome_Homo sapiens_hsa030101.90985181
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87722303
22Tryptophan metabolism_Homo sapiens_hsa003801.86573774
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86399064
24Cholinergic synapse_Homo sapiens_hsa047251.85996550
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85452618
26Fanconi anemia pathway_Homo sapiens_hsa034601.83071089
27Serotonergic synapse_Homo sapiens_hsa047261.82920056
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76032245
29Non-homologous end-joining_Homo sapiens_hsa034501.74867816
30Calcium signaling pathway_Homo sapiens_hsa040201.74269338
31Collecting duct acid secretion_Homo sapiens_hsa049661.72698540
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71532841
33Renin secretion_Homo sapiens_hsa049241.70406250
34Linoleic acid metabolism_Homo sapiens_hsa005911.70211052
35Long-term depression_Homo sapiens_hsa047301.69557873
36Oxytocin signaling pathway_Homo sapiens_hsa049211.68065318
37Gastric acid secretion_Homo sapiens_hsa049711.67069413
38Propanoate metabolism_Homo sapiens_hsa006401.63318447
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58752561
40RNA degradation_Homo sapiens_hsa030181.58372356
41Proteasome_Homo sapiens_hsa030501.54566277
42Basal transcription factors_Homo sapiens_hsa030221.52661828
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50653704
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.50395514
45Cocaine addiction_Homo sapiens_hsa050301.46288463
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44695689
47Phototransduction_Homo sapiens_hsa047441.39898077
48GnRH signaling pathway_Homo sapiens_hsa049121.37381423
49Peroxisome_Homo sapiens_hsa041461.33196246
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32848238
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28228621
52Mismatch repair_Homo sapiens_hsa034301.27060322
53Cardiac muscle contraction_Homo sapiens_hsa042601.27059862
54Gap junction_Homo sapiens_hsa045401.25510478
55Selenocompound metabolism_Homo sapiens_hsa004501.24598491
56cAMP signaling pathway_Homo sapiens_hsa040241.23691767
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20758954
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19341117
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17312869
60Type II diabetes mellitus_Homo sapiens_hsa049301.16700488
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16506314
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13248356
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12719780
64Base excision repair_Homo sapiens_hsa034101.12030266
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09422368
66Vibrio cholerae infection_Homo sapiens_hsa051101.09184754
67beta-Alanine metabolism_Homo sapiens_hsa004101.08986141
68Dilated cardiomyopathy_Homo sapiens_hsa054141.07757743
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07351263
70Retinol metabolism_Homo sapiens_hsa008301.06839848
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05323545
72Ether lipid metabolism_Homo sapiens_hsa005651.05289113
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05173081
74Fatty acid degradation_Homo sapiens_hsa000711.04641007
75Chemical carcinogenesis_Homo sapiens_hsa052041.04313032
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03749837
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03403599
78Primary bile acid biosynthesis_Homo sapiens_hsa001201.01853715
79ErbB signaling pathway_Homo sapiens_hsa040121.00025445
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99666973
81Melanogenesis_Homo sapiens_hsa049160.97865150
82RNA transport_Homo sapiens_hsa030130.97619380
83DNA replication_Homo sapiens_hsa030300.97120278
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.95798008
85Nitrogen metabolism_Homo sapiens_hsa009100.94752215
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93951290
87Glioma_Homo sapiens_hsa052140.93750537
88Nucleotide excision repair_Homo sapiens_hsa034200.93650760
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93569428
90Estrogen signaling pathway_Homo sapiens_hsa049150.93256364
91Pyrimidine metabolism_Homo sapiens_hsa002400.93183330
92One carbon pool by folate_Homo sapiens_hsa006700.89338326
93Axon guidance_Homo sapiens_hsa043600.89194368
94Purine metabolism_Homo sapiens_hsa002300.88991618
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87634542
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.86115224
97Glycerolipid metabolism_Homo sapiens_hsa005610.85821400
98Histidine metabolism_Homo sapiens_hsa003400.85707496
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84329035
100Spliceosome_Homo sapiens_hsa030400.83644709
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.83442869
102Fatty acid elongation_Homo sapiens_hsa000620.83226199
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81879404
104Dorso-ventral axis formation_Homo sapiens_hsa043200.81577578
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80614336
106Hedgehog signaling pathway_Homo sapiens_hsa043400.79265643
107Glucagon signaling pathway_Homo sapiens_hsa049220.79084260
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78863267
109Alzheimers disease_Homo sapiens_hsa050100.77551192
110Fat digestion and absorption_Homo sapiens_hsa049750.76984942
111Circadian rhythm_Homo sapiens_hsa047100.75716948
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75486957
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75163917
114Pyruvate metabolism_Homo sapiens_hsa006200.74980321
115Type I diabetes mellitus_Homo sapiens_hsa049400.73984745
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73292816
117Metabolic pathways_Homo sapiens_hsa011000.73249814
118MAPK signaling pathway_Homo sapiens_hsa040100.72836088
119Arachidonic acid metabolism_Homo sapiens_hsa005900.69122946
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67886607
121Vitamin digestion and absorption_Homo sapiens_hsa049770.67463861
122Oxidative phosphorylation_Homo sapiens_hsa001900.67062783
123Pancreatic secretion_Homo sapiens_hsa049720.66864081
124Thyroid hormone synthesis_Homo sapiens_hsa049180.65707255
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65136838
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61638993
127Choline metabolism in cancer_Homo sapiens_hsa052310.61034841
128Oocyte meiosis_Homo sapiens_hsa041140.60825930
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.59245777
130Basal cell carcinoma_Homo sapiens_hsa052170.58763868
131African trypanosomiasis_Homo sapiens_hsa051430.56987852
132Fatty acid metabolism_Homo sapiens_hsa012120.56708581
133Arginine and proline metabolism_Homo sapiens_hsa003300.54174202
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53639929
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.52994843
136Ras signaling pathway_Homo sapiens_hsa040140.51311419
137Inositol phosphate metabolism_Homo sapiens_hsa005620.50602134
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49835030
139Lysine degradation_Homo sapiens_hsa003100.48776460
140Sulfur metabolism_Homo sapiens_hsa009200.48417588
141Parkinsons disease_Homo sapiens_hsa050120.47349044
142Rap1 signaling pathway_Homo sapiens_hsa040150.47013394
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46333970
144Insulin signaling pathway_Homo sapiens_hsa049100.45695431
145ABC transporters_Homo sapiens_hsa020100.45652044
146mTOR signaling pathway_Homo sapiens_hsa041500.41946582
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41816301
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41195214
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40683937
150Mineral absorption_Homo sapiens_hsa049780.40303354
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39720145
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.39002823
153Wnt signaling pathway_Homo sapiens_hsa043100.38569251
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37076190
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36758094
156Rheumatoid arthritis_Homo sapiens_hsa053230.36732572
157Regulation of autophagy_Homo sapiens_hsa041400.36024388
158Endometrial cancer_Homo sapiens_hsa052130.35823850
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34993161
160Alcoholism_Homo sapiens_hsa050340.34833979
161Bile secretion_Homo sapiens_hsa049760.34640869
162Ovarian steroidogenesis_Homo sapiens_hsa049130.34260851
163Prion diseases_Homo sapiens_hsa050200.31127143
164Huntingtons disease_Homo sapiens_hsa050160.28637717
165VEGF signaling pathway_Homo sapiens_hsa043700.27428912
166Non-small cell lung cancer_Homo sapiens_hsa052230.25706902
167Butanoate metabolism_Homo sapiens_hsa006500.25680769
168Melanoma_Homo sapiens_hsa052180.25214930
169Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21248592
170Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21111099
171Arginine biosynthesis_Homo sapiens_hsa002200.20789918

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