TTC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.31080356
2cilium movement (GO:0003341)8.94755110
3epithelial cilium movement (GO:0003351)7.96472809
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.71833291
5axoneme assembly (GO:0035082)6.52968520
6fusion of sperm to egg plasma membrane (GO:0007342)6.40540273
7motile cilium assembly (GO:0044458)6.36439119
8central nervous system myelination (GO:0022010)6.35052154
9axon ensheathment in central nervous system (GO:0032291)6.35052154
10ventricular system development (GO:0021591)5.62553500
11sperm motility (GO:0030317)5.56075898
12multicellular organism reproduction (GO:0032504)5.48070191
13piRNA metabolic process (GO:0034587)5.27925684
14primary alcohol catabolic process (GO:0034310)5.26709901
15diterpenoid biosynthetic process (GO:0016102)5.17709969
16centriole assembly (GO:0098534)4.90425862
17vitamin transmembrane transport (GO:0035461)4.86914287
18sperm-egg recognition (GO:0035036)4.85887658
19establishment of apical/basal cell polarity (GO:0035089)4.84238809
20plasma membrane fusion (GO:0045026)4.75515315
21acrosome reaction (GO:0007340)4.68673959
22negative regulation of inclusion body assembly (GO:0090084)4.68516988
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.60519645
24reproduction (GO:0000003)4.52254139
25acrosome assembly (GO:0001675)4.45576122
26cell wall macromolecule catabolic process (GO:0016998)4.37978822
27cell wall macromolecule metabolic process (GO:0044036)4.37978822
28binding of sperm to zona pellucida (GO:0007339)4.33683761
29spermatid development (GO:0007286)4.30900165
30ethanol metabolic process (GO:0006067)4.24985774
31cell-cell recognition (GO:0009988)4.24287632
32peptidyl-tyrosine autophosphorylation (GO:0038083)4.21213915
33cell projection assembly (GO:0030031)4.10320955
34regulation of cilium movement (GO:0003352)4.01942482
35negative regulation of humoral immune response (GO:0002921)3.99761953
36sperm capacitation (GO:0048240)3.95556996
37establishment or maintenance of monopolar cell polarity (GO:0061339)3.89957464
38establishment of monopolar cell polarity (GO:0061162)3.89957464
39lung epithelium development (GO:0060428)3.83635846
40GTP biosynthetic process (GO:0006183)3.76612325
41single fertilization (GO:0007338)3.73087562
42synaptonemal complex organization (GO:0070193)3.72008776
43hypotonic response (GO:0006971)3.71607588
44male meiosis (GO:0007140)3.71286040
45nucleoside diphosphate phosphorylation (GO:0006165)3.68960073
46glomerular epithelial cell development (GO:0072310)3.67000534
47tolerance induction (GO:0002507)3.64226358
48terpenoid biosynthetic process (GO:0016114)3.63327311
49peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.60865222
50regulation of interleukin-5 production (GO:0032674)3.58361334
51histone H3-K36 demethylation (GO:0070544)3.58176040
52cytoplasmic microtubule organization (GO:0031122)3.56376161
53cilium morphogenesis (GO:0060271)3.51930588
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.51642910
55microtubule severing (GO:0051013)3.48700121
56left/right pattern formation (GO:0060972)3.48406337
57negative regulation of T cell differentiation in thymus (GO:0033085)3.44157870
58negative regulation of B cell mediated immunity (GO:0002713)3.43085346
59negative regulation of immunoglobulin mediated immune response (GO:0002890)3.43085346
60intraciliary transport (GO:0042073)3.40069035
61response to xenobiotic stimulus (GO:0009410)3.36419307
62myelination (GO:0042552)3.33386125
63sarcomere organization (GO:0045214)3.33277452
64left/right axis specification (GO:0070986)3.32846721
65axon ensheathment (GO:0008366)3.31963791
66ensheathment of neurons (GO:0007272)3.31963791
67cardiac myofibril assembly (GO:0055003)3.31544250
68microtubule bundle formation (GO:0001578)3.30382248
69regulation of skeletal muscle contraction (GO:0014819)3.29451236
70lateral ventricle development (GO:0021670)3.26113401
71cellular component assembly involved in morphogenesis (GO:0010927)3.25530578
72regulation of inclusion body assembly (GO:0090083)3.22203393
73retinoic acid metabolic process (GO:0042573)3.22045317
74UTP biosynthetic process (GO:0006228)3.20750938
75iron ion import (GO:0097286)3.19771987
76embryonic camera-type eye development (GO:0031076)3.17773151
77fertilization (GO:0009566)3.15775091
78myofibril assembly (GO:0030239)3.13811776
79positive regulation of respiratory burst (GO:0060267)3.12819453
80one-carbon compound transport (GO:0019755)3.12694112
81eye photoreceptor cell differentiation (GO:0001754)3.12425943
82photoreceptor cell differentiation (GO:0046530)3.12425943
83cilium organization (GO:0044782)3.12276200
84otic vesicle formation (GO:0030916)3.12010811
85establishment of planar polarity (GO:0001736)3.10932589
86establishment of tissue polarity (GO:0007164)3.10932589
87establishment of nucleus localization (GO:0040023)3.05728638
88negative regulation of potassium ion transmembrane transport (GO:1901380)3.05440480
89positive regulation of smoothened signaling pathway (GO:0045880)3.04064586
90retinal rod cell development (GO:0046548)3.02640896
91smoothened signaling pathway (GO:0007224)3.00142560
92DNA methylation involved in gamete generation (GO:0043046)3.00129450
93endocardial cushion morphogenesis (GO:0003203)2.97714374
94regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.97094491
95ethanol oxidation (GO:0006069)2.96193815
96cilium assembly (GO:0042384)2.94938274
97meiotic cell cycle (GO:0051321)2.93677154
98regulation of interleukin-13 production (GO:0032656)2.91937131
99negative regulation of skeletal muscle tissue development (GO:0048642)2.91856347
100UTP metabolic process (GO:0046051)2.91467783
101negative regulation of protein localization to cell surface (GO:2000009)2.91139824
102spermatogenesis (GO:0007283)2.89840585
103histone H3-K9 demethylation (GO:0033169)2.89782222
104male gamete generation (GO:0048232)2.87728609
105asymmetric protein localization (GO:0008105)2.87660072
106cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.86276376
107microtubule-based movement (GO:0007018)2.85848423
108synaptonemal complex assembly (GO:0007130)2.84834893
109astrocyte development (GO:0014002)2.84406838
110lateral sprouting from an epithelium (GO:0060601)2.84088180
111multicellular organismal water homeostasis (GO:0050891)2.83640469
112Golgi transport vesicle coating (GO:0048200)2.80079354
113COPI coating of Golgi vesicle (GO:0048205)2.80079354
114carnitine metabolic process (GO:0009437)2.80049524
115virion attachment to host cell (GO:0019062)2.78990199
116adhesion of symbiont to host cell (GO:0044650)2.78990199
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.78506124
118cellular response to cadmium ion (GO:0071276)2.77893962
119myelination in peripheral nervous system (GO:0022011)2.77432635
120peripheral nervous system axon ensheathment (GO:0032292)2.77432635
121O-glycan processing (GO:0016266)2.77209170
122positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76678464
123microtubule-based process (GO:0007017)2.74305893
124determination of left/right symmetry (GO:0007368)2.73622614
125determination of bilateral symmetry (GO:0009855)2.72268916
126specification of symmetry (GO:0009799)2.70413271
127glutathione derivative metabolic process (GO:1901685)2.70374962
128glutathione derivative biosynthetic process (GO:1901687)2.70374962
129centriole replication (GO:0007099)2.69934653
130organelle assembly (GO:0070925)2.69718186
131male meiosis I (GO:0007141)2.67779364
132camera-type eye morphogenesis (GO:0048593)2.66152193
133glomerular filtration (GO:0003094)2.65847531
134gamete generation (GO:0007276)2.64675069
135pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63946558
136import into cell (GO:0098657)2.63442983
137primary alcohol metabolic process (GO:0034308)2.60031199
138ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.58839806
139microtubule depolymerization (GO:0007019)2.58191668
140positive regulation of tolerance induction (GO:0002645)2.56894715
141retinol metabolic process (GO:0042572)2.56202921
142regulation of microtubule-based movement (GO:0060632)2.55673305
143CTP biosynthetic process (GO:0006241)2.52029729
144CTP metabolic process (GO:0046036)2.52029729
145microtubule polymerization or depolymerization (GO:0031109)2.51821295
146establishment or maintenance of bipolar cell polarity (GO:0061245)2.51390458
147establishment or maintenance of apical/basal cell polarity (GO:0035088)2.51390458
148oxygen transport (GO:0015671)2.50716273
149adult heart development (GO:0007512)2.50615188
150renal filtration (GO:0097205)2.50113290
151positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.49862251
152positive regulation of macrophage cytokine production (GO:0060907)2.49648468
153actin-myosin filament sliding (GO:0033275)2.48973645
154muscle filament sliding (GO:0030049)2.48973645
155excretion (GO:0007588)2.48849163
156protein localization to cilium (GO:0061512)2.47908614
157branching involved in salivary gland morphogenesis (GO:0060445)2.47239476
158actomyosin structure organization (GO:0031032)2.46364295
159regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.45840781
160photoreceptor cell maintenance (GO:0045494)2.44109750
161water homeostasis (GO:0030104)2.44028759
162interleukin-6-mediated signaling pathway (GO:0070102)2.43742801
163regulation of microtubule depolymerization (GO:0031114)2.41817264
164embryonic body morphogenesis (GO:0010172)2.40353435
165pyrimidine nucleotide catabolic process (GO:0006244)2.37756138
166radial glial cell differentiation (GO:0060019)2.37541390
167regulation of autophagic vacuole assembly (GO:2000785)2.37137603
168nonmotile primary cilium assembly (GO:0035058)2.34470473
169membrane protein intracellular domain proteolysis (GO:0031293)2.34447811
170regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33738780
171nucleus localization (GO:0051647)2.33251748
172limb development (GO:0060173)2.28979987
173cilium or flagellum-dependent cell motility (GO:0001539)11.1990959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.19498883
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.24526224
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.66947719
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.59800596
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13222317
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.06077921
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.89472240
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.78637706
9FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.52286665
10EZH2_22144423_ChIP-Seq_EOC_Human2.41171450
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.36259372
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34004254
13ZNF263_19887448_ChIP-Seq_K562_Human2.32484762
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.23575319
15RUNX1_27514584_Chip-Seq_MCF-7_Human2.21180995
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.15171800
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13895906
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13413849
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08617155
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.08193686
21FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.05708613
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00844404
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.98238342
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91012901
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90717714
26VDR_22108803_ChIP-Seq_LS180_Human1.90597850
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88012353
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81920343
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.81036511
30FOXA1_25552417_ChIP-Seq_VCAP_Human1.80292195
31* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.79967817
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79777674
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77897116
34FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.76740389
35* TP63_23658742_ChIP-Seq_EP156T_Human1.66756378
36GATA3_24758297_ChIP-Seq_MCF-7_Human1.63099469
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62570884
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.61512561
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56261432
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55827309
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.55147451
42SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.54031741
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53361175
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53174811
45GATA4_25053715_ChIP-Seq_YYC3_Human1.51615740
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.51064836
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49597473
48KLF5_25053715_ChIP-Seq_YYC3_Human1.48961016
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46307556
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46197111
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.45437641
52DROSHA_22980978_ChIP-Seq_HELA_Human1.45102134
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44781662
54CHD1_26751641_Chip-Seq_LNCaP_Human1.44771593
55GATA6_25053715_ChIP-Seq_YYC3_Human1.44680334
56SOX2_20726797_ChIP-Seq_SW620_Human1.43849276
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.43734774
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42817358
59* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42061889
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41482571
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40884741
62SMC4_20622854_ChIP-Seq_HELA_Human1.39519566
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.38024575
64CJUN_26792858_Chip-Seq_BT549_Human1.37144720
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.35761136
66AR_21909140_ChIP-Seq_LNCAP_Human1.35255498
67TP63_22573176_ChIP-Seq_HFKS_Human1.34536070
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32582695
69ER_23166858_ChIP-Seq_MCF-7_Human1.32360864
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32297148
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29472940
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28327441
73* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.25744120
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.25511038
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.25511038
76TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24359559
77* RACK7_27058665_Chip-Seq_MCF-7_Human1.24302213
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24105015
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23510740
80GBX2_23144817_ChIP-Seq_PC3_Human1.22994032
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.21883209
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21145618
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19117458
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19117458
85* SMAD3_21741376_ChIP-Seq_EPCs_Human1.18854535
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.17511914
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17336663
88BCAT_22108803_ChIP-Seq_LS180_Human1.16879224
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16861500
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16236435
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15988238
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14917915
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14464147
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13986581
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13465922
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12704570
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12704570
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12704570
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12478860
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11386701
101SMAD4_21799915_ChIP-Seq_A2780_Human1.08400175
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07884925
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.07262582
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.07138584
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.07022750
106* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06745433
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06295459
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05701511
109GABP_19822575_ChIP-Seq_HepG2_Human1.02924902
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01509973
111ELF5_23300383_ChIP-Seq_T47D_Human1.01306474
112TP53_16413492_ChIP-PET_HCT116_Human1.01298613
113TBL1_22424771_ChIP-Seq_293T_Human1.00746477
114EZH2_27294783_Chip-Seq_ESCs_Mouse1.00626068
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00375725
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99178465
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99106029
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98749874
119AHR_22903824_ChIP-Seq_MCF-7_Human0.98645454
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.98110618
121AR_21572438_ChIP-Seq_LNCaP_Human0.98038367
122PHF8_20622854_ChIP-Seq_HELA_Human0.96414343
123GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.96396141
124RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96361793
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96154618
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.96129764
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94895529
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94710960
129* TP53_18474530_ChIP-ChIP_U2OS_Human0.94327628
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.94114534
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.93706836
132HNFA_21074721_ChIP-Seq_CACO-2_Human0.93144086
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92749579
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92617242
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92099905
136SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92092748
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92055648
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91933840
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91699181
140TCF4_23295773_ChIP-Seq_U87_Human0.91676513
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91551561
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91551561
143P300_27268052_Chip-Seq_Bcells_Human0.91355845
144* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90678540
145SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90620954
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90501565
147PHF8_20622853_ChIP-Seq_HELA_Human0.90036220
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89733045
149RNF2_27304074_Chip-Seq_ESCs_Mouse0.89427384
150GATA1_22025678_ChIP-Seq_K562_Human0.89353322
151CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89004469
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88867050
153* CBP_21632823_ChIP-Seq_H3396_Human0.88765635
154P300_19829295_ChIP-Seq_ESCs_Human0.88682282
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88529959
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88336358
157* NFYB_21822215_ChIP-Seq_K562_Human0.88124610
158* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87728429
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.87298869
160IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86846047
161CBP_20019798_ChIP-Seq_JUKART_Human0.86846047
162KDM2B_26808549_Chip-Seq_REH_Human0.86392038
163GF1_26923725_Chip-Seq_HPCs_Mouse0.86246422
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86231172
165HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86139676
166STAT1_20625510_ChIP-Seq_HELA_Human0.85952751
167TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85836666
168MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85567764
169SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85295551
170E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84802963
171P68_20966046_ChIP-Seq_HELA_Human0.83340434
172ETV1_20927104_ChIP-Seq_GIST48_Human0.82129785
173SRF_21415370_ChIP-Seq_HL-1_Mouse0.81632268
174TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81174446
175ERG_20517297_ChIP-Seq_VCAP_Human0.81141633
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79376956
177ESR1_21235772_ChIP-Seq_MCF-7_Human0.78984236
178GABP_17652178_ChIP-ChIP_JURKAT_Human0.78768851
179FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77586695
180LXR_22158963_ChIP-Seq_LIVER_Mouse0.77040094
181PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76719848
182SMRT_27268052_Chip-Seq_Bcells_Human0.76218749
183PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.75607952
184EOMES_21245162_ChIP-Seq_HESCs_Human0.75040277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.64760593
2MP0008875_abnormal_xenobiotic_pharmacok4.53345142
3MP0003950_abnormal_plasma_membrane4.24087584
4MP0005623_abnormal_meninges_morphology4.04315507
5MP0002132_abnormal_respiratory_system3.95102987
6MP0008438_abnormal_cutaneous_collagen3.76565197
7MP0003136_yellow_coat_color3.68146320
8MP0005503_abnormal_tendon_morphology3.53358302
9MP0008789_abnormal_olfactory_epithelium3.31130810
10MP0000751_myopathy3.25494669
11MP0009780_abnormal_chondrocyte_physiolo3.15100987
12MP0002277_abnormal_respiratory_mucosa2.98555176
13MP0010234_abnormal_vibrissa_follicle2.72345651
14MP0000749_muscle_degeneration2.71523026
15MP0005275_abnormal_skin_tensile2.64344023
16MP0001984_abnormal_olfaction2.63409282
17MP0003656_abnormal_erythrocyte_physiolo2.55557172
18MP0004084_abnormal_cardiac_muscle2.52173385
19MP0002837_dystrophic_cardiac_calcinosis2.46576339
20MP0005499_abnormal_olfactory_system2.25550825
21MP0005394_taste/olfaction_phenotype2.25550825
22MP0002653_abnormal_ependyma_morphology2.17535598
23MP0000566_synostosis2.14111669
24MP0003191_abnormal_cellular_cholesterol2.08230376
25MP0003690_abnormal_glial_cell2.06762535
26MP0002928_abnormal_bile_duct2.06591679
27MP0004036_abnormal_muscle_relaxation2.03991706
28MP0004133_heterotaxia2.03232570
29MP0004272_abnormal_basement_membrane2.01204232
30MP0003698_abnormal_male_reproductive1.98554150
31MP0002108_abnormal_muscle_morphology1.97066867
32MP0000920_abnormal_myelination1.94545922
33MP0005330_cardiomyopathy1.81570781
34MP0005171_absent_coat_pigmentation1.80014539
35MP0004215_abnormal_myocardial_fiber1.78891743
36MP0001346_abnormal_lacrimal_gland1.77438412
37MP0000678_abnormal_parathyroid_gland1.77261057
38MP0003279_aneurysm1.73665340
39MP0004043_abnormal_pH_regulation1.71240529
40MP0002168_other_aberrant_phenotype1.69885702
41MP0001958_emphysema1.68049762
42MP0005408_hypopigmentation1.66053342
43MP0003646_muscle_fatigue1.64148800
44MP0001929_abnormal_gametogenesis1.63409535
45MP0003566_abnormal_cell_adhesion1.59536051
46MP0004019_abnormal_vitamin_homeostasis1.55170928
47MP0003453_abnormal_keratinocyte_physiol1.54608486
48MP0006138_congestive_heart_failure1.53681997
49MP0000750_abnormal_muscle_regeneration1.48228948
50MP0005083_abnormal_biliary_tract1.46312395
51MP0005395_other_phenotype1.45596105
52MP0003634_abnormal_glial_cell1.45146760
53MP0000383_abnormal_hair_follicle1.42927617
54MP0004264_abnormal_extraembryonic_tissu1.40835084
55MP0004087_abnormal_muscle_fiber1.35349641
56MP0005310_abnormal_salivary_gland1.34738418
57MP0002972_abnormal_cardiac_muscle1.34734553
58MP0003941_abnormal_skin_development1.32804800
59MP0002233_abnormal_nose_morphology1.31589643
60MP0002249_abnormal_larynx_morphology1.31182422
61MP0001765_abnormal_ion_homeostasis1.31075035
62MP0005670_abnormal_white_adipose1.29940606
63MP0008775_abnormal_heart_ventricle1.29463365
64MP0002295_abnormal_pulmonary_circulatio1.29284068
65MP0001485_abnormal_pinna_reflex1.27844725
66MP0003137_abnormal_impulse_conducting1.26909951
67MP0004858_abnormal_nervous_system1.26398194
68MP0010630_abnormal_cardiac_muscle1.24719923
69MP0002084_abnormal_developmental_patter1.23342804
70MP0005620_abnormal_muscle_contractility1.20022992
71MP0005508_abnormal_skeleton_morphology1.19126961
72MP0005389_reproductive_system_phenotype1.17382426
73MP0008260_abnormal_autophagy1.16947872
74MP0005248_abnormal_Harderian_gland1.16550166
75MP0000747_muscle_weakness1.16478518
76MP0001293_anophthalmia1.15256671
77MP0003943_abnormal_hepatobiliary_system1.14297094
78MP0005369_muscle_phenotype1.13323722
79MP0005257_abnormal_intraocular_pressure1.12712730
80MP0003937_abnormal_limbs/digits/tail_de1.12208326
81MP0010030_abnormal_orbit_morphology1.11928893
82MP0005165_increased_susceptibility_to1.10432115
83MP0000681_abnormal_thyroid_gland1.10045907
84MP0005385_cardiovascular_system_phenoty1.09870212
85MP0001544_abnormal_cardiovascular_syste1.09870212
86MP0008004_abnormal_stomach_pH1.07955899
87MP0009703_decreased_birth_body1.04152205
88MP0003890_abnormal_embryonic-extraembry1.04145892
89MP0002282_abnormal_trachea_morphology1.03308599
90MP0003866_abnormal_defecation1.02085862
91MP0000579_abnormal_nail_morphology1.01876427
92MP0000759_abnormal_skeletal_muscle1.00741196
93MP0002210_abnormal_sex_determination0.99645996
94MP0003828_pulmonary_edema0.98391630
95MP0002234_abnormal_pharynx_morphology0.97970563
96MP0004085_abnormal_heartbeat0.97476281
97MP0002106_abnormal_muscle_physiology0.96884253
98MP0001299_abnormal_eye_distance/0.96710385
99MP0001661_extended_life_span0.96306788
100MP0004742_abnormal_vestibular_system0.94376159
101MP0003936_abnormal_reproductive_system0.93866735
102MP0002161_abnormal_fertility/fecundity0.93759868
103MP0009643_abnormal_urine_homeostasis0.93570507
104MP0005636_abnormal_mineral_homeostasis0.93536601
105MP0003718_maternal_effect0.93273361
106MP0004233_abnormal_muscle_weight0.92123983
107MP0002332_abnormal_exercise_endurance0.91417245
108MP0003186_abnormal_redox_activity0.91080796
109MP0002269_muscular_atrophy0.90969163
110MP0000428_abnormal_craniofacial_morphol0.89283924
111MP0001849_ear_inflammation0.87393798
112MP0001324_abnormal_eye_pigmentation0.87237870
113MP0001286_abnormal_eye_development0.86985075
114MP0002938_white_spotting0.86627114
115MP0000377_abnormal_hair_follicle0.84480429
116MP0010386_abnormal_urinary_bladder0.84193721
117MP0000762_abnormal_tongue_morphology0.83823872
118MP0009046_muscle_twitch0.80933054
119MP0005388_respiratory_system_phenotype0.80214053
120MP0002133_abnormal_respiratory_system0.80214053
121MP0003878_abnormal_ear_physiology0.79770372
122MP0005377_hearing/vestibular/ear_phenot0.79770372
123MP0004484_altered_response_of0.79586984
124MP0001216_abnormal_epidermal_layer0.79546538
125MP0004510_myositis0.78918715
126MP0001879_abnormal_lymphatic_vessel0.78505380
127MP0010678_abnormal_skin_adnexa0.78421597
128MP0001145_abnormal_male_reproductive0.78063824
129MP0001905_abnormal_dopamine_level0.77817678
130MP0000358_abnormal_cell_content/0.77454773
131MP0003091_abnormal_cell_migration0.77018901
132MP0003938_abnormal_ear_development0.76558888
133MP0000653_abnormal_sex_gland0.75793747
134MP0000733_abnormal_muscle_development0.75387812
135MP0010352_gastrointestinal_tract_polyps0.75233247
136MP0004782_abnormal_surfactant_physiolog0.75116669
137MP0002085_abnormal_embryonic_tissue0.74846179
138MP0002163_abnormal_gland_morphology0.74432933
139MP0000778_abnormal_nervous_system0.74187289
140MP0003385_abnormal_body_wall0.74099615
141MP0009250_abnormal_appendicular_skeleto0.73760288
142MP0002136_abnormal_kidney_physiology0.73535708
143MP0010155_abnormal_intestine_physiology0.73469700
144MP0002876_abnormal_thyroid_physiology0.73370877
145MP0001727_abnormal_embryo_implantation0.73015477
146MP0000427_abnormal_hair_cycle0.72700260
147MP0003115_abnormal_respiratory_system0.72253650
148MP0001944_abnormal_pancreas_morphology0.72009703
149MP0000049_abnormal_middle_ear0.70481065
150MP0005220_abnormal_exocrine_pancreas0.69850805
151MP0005595_abnormal_vascular_smooth0.69295038
152MP0003942_abnormal_urinary_system0.68741232
153MP0000647_abnormal_sebaceous_gland0.67594267
154MP0000627_abnormal_mammary_gland0.67446216
155MP0005666_abnormal_adipose_tissue0.67190500
156MP0001672_abnormal_embryogenesis/_devel0.66856473
157MP0005380_embryogenesis_phenotype0.66856473
158MP0002909_abnormal_adrenal_gland0.66805864
159MP0010368_abnormal_lymphatic_system0.66204992
160MP0002697_abnormal_eye_size0.64686715
161MP0002092_abnormal_eye_morphology0.64109931
162MP0002009_preneoplasia0.64013793
163MP0002139_abnormal_hepatobiliary_system0.63579692
164MP0002127_abnormal_cardiovascular_syste0.63451320
165MP0004381_abnormal_hair_follicle0.62499932
166MP0002796_impaired_skin_barrier0.61994462
167MP0005253_abnormal_eye_physiology0.61891920
168MP0005646_abnormal_pituitary_gland0.61642068
169MP0002160_abnormal_reproductive_system0.61640947
170MP0002088_abnormal_embryonic_growth/wei0.60711041
171MP0003984_embryonic_growth_retardation0.60526122
172MP0002638_abnormal_pupillary_reflex0.60404113
173MP0005023_abnormal_wound_healing0.59798546
174MP0005391_vision/eye_phenotype0.59298789
175MP0000432_abnormal_head_morphology0.59224015

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.53368637
2Abnormal ciliary motility (HP:0012262)7.91270033
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.61835096
4Absent/shortened dynein arms (HP:0200106)7.61835096
5Abnormal respiratory epithelium morphology (HP:0012253)7.25362565
6Abnormal respiratory motile cilium morphology (HP:0005938)7.25362565
7Rhinitis (HP:0012384)7.10377555
8Chronic bronchitis (HP:0004469)4.51721695
9Neonatal short-limb short stature (HP:0008921)4.08463443
10Chronic sinusitis (HP:0011109)3.95302266
11Tubulointerstitial nephritis (HP:0001970)3.77054788
12Atelectasis (HP:0100750)3.69734604
13Occipital encephalocele (HP:0002085)3.60185778
14Bronchiectasis (HP:0002110)3.48876421
15Nasal polyposis (HP:0100582)3.36568795
16Retinal dysplasia (HP:0007973)3.29563023
17Abnormality of the dental root (HP:0006486)3.08556508
18Taurodontia (HP:0000679)3.08556508
19Abnormality of permanent molar morphology (HP:0011071)3.08556508
20Abnormality of molar morphology (HP:0011070)3.08503843
21Abnormality of molar (HP:0011077)3.08503843
22Abnormality of the nasal mucosa (HP:0000433)2.98474929
23Infertility (HP:0000789)2.94121030
24Abnormality of midbrain morphology (HP:0002418)2.90693209
25Molar tooth sign on MRI (HP:0002419)2.90693209
26Abnormality of the dental pulp (HP:0006479)2.85449201
27Hyperactive renin-angiotensin system (HP:0000841)2.84215469
28Cystic liver disease (HP:0006706)2.83964745
29Hyporeflexia of lower limbs (HP:0002600)2.79455704
30Nephronophthisis (HP:0000090)2.78892900
31Atrial fibrillation (HP:0005110)2.75824698
32Muscle fiber splitting (HP:0003555)2.74816247
33Ventricular tachycardia (HP:0004756)2.73337522
34Sudden death (HP:0001699)2.65475176
35Chronic hepatic failure (HP:0100626)2.64870664
36Natal tooth (HP:0000695)2.54014279
37Primary atrial arrhythmia (HP:0001692)2.53638293
38Pancreatic cysts (HP:0001737)2.40672483
39Abnormality of dentin (HP:0010299)2.40100245
40Chronic otitis media (HP:0000389)2.39260332
41Abnormality of the calf musculature (HP:0001430)2.36001624
42Short nail (HP:0001799)2.35965015
43Follicular hyperkeratosis (HP:0007502)2.35842977
44Supraventricular tachycardia (HP:0004755)2.35255558
45Ileus (HP:0002595)2.34346545
46Supraventricular arrhythmia (HP:0005115)2.32230437
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31586142
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.31586142
49Aplasia involving bones of the extremities (HP:0009825)2.28238321
50Aplasia involving bones of the upper limbs (HP:0009823)2.28238321
51Aplasia of the phalanges of the hand (HP:0009802)2.28238321
52Glucose intolerance (HP:0000833)2.27680237
53Medial flaring of the eyebrow (HP:0010747)2.27363073
54Facial cleft (HP:0002006)2.27066043
55Congenital, generalized hypertrichosis (HP:0004540)2.25538168
56Calf muscle hypertrophy (HP:0008981)2.24569805
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.24373518
58Right ventricular cardiomyopathy (HP:0011663)2.20473621
59Recurrent bronchitis (HP:0002837)2.18405262
60Bell-shaped thorax (HP:0001591)2.17772805
61Congenital primary aphakia (HP:0007707)2.17694781
62Male pseudohermaphroditism (HP:0000037)2.15237301
63Premature rupture of membranes (HP:0001788)2.15007208
64Muscle hypertrophy of the lower extremities (HP:0008968)2.14744523
65Median cleft lip (HP:0000161)2.13436604
66Postaxial foot polydactyly (HP:0001830)2.12644171
67Abnormality of the renal medulla (HP:0100957)2.12154136
68Fibular hypoplasia (HP:0003038)2.11839345
69Advanced eruption of teeth (HP:0006288)2.11000671
70Lipoatrophy (HP:0100578)2.05829368
71Bronchitis (HP:0012387)2.03689547
72Bronchomalacia (HP:0002780)2.03059519
73Coronal craniosynostosis (HP:0004440)2.01839655
74Diaphragmatic weakness (HP:0009113)2.00911566
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1487840
76Exercise-induced muscle cramps (HP:0003710)1.99775947
77Gait imbalance (HP:0002141)1.96003864
78Thick nail (HP:0001805)1.95462962
79Prolonged QT interval (HP:0001657)1.92979555
80Pancreatic islet-cell hyperplasia (HP:0004510)1.92890488
81Nephrogenic diabetes insipidus (HP:0009806)1.91875217
82Metaphyseal dysplasia (HP:0100255)1.90376251
83Anencephaly (HP:0002323)1.90327163
84Congenital hepatic fibrosis (HP:0002612)1.89576664
85Conical tooth (HP:0000698)1.88813356
86Foot dorsiflexor weakness (HP:0009027)1.88713570
87Pulmonary artery stenosis (HP:0004415)1.84037750
88Recurrent sinusitis (HP:0011108)1.83340091
89Oculomotor apraxia (HP:0000657)1.82966190
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82908056
91Postaxial hand polydactyly (HP:0001162)1.82065734
92Abnormal number of incisors (HP:0011064)1.82065439
93Tubular atrophy (HP:0000092)1.81831320
94Prostate neoplasm (HP:0100787)1.81176671
95Hyperkalemia (HP:0002153)1.78165066
96Neurofibrillary tangles (HP:0002185)1.76910494
97Genital tract atresia (HP:0001827)1.76058994
98Spinal rigidity (HP:0003306)1.74529067
99Abnormality of the foot musculature (HP:0001436)1.74132243
100Abnormality of the distal phalanges of the toes (HP:0010182)1.71704670
101Hyperinsulinemic hypoglycemia (HP:0000825)1.70710860
102Cone-rod dystrophy (HP:0000548)1.70661303
103Abnormality of abdominal situs (HP:0011620)1.69093192
104Abdominal situs inversus (HP:0003363)1.69093192
105Tubulointerstitial abnormality (HP:0001969)1.68813357
106Poor coordination (HP:0002370)1.66847634
107Broad metatarsal (HP:0001783)1.66640990
108Stage 5 chronic kidney disease (HP:0003774)1.66397287
109Nephropathy (HP:0000112)1.65772604
110Dilated cardiomyopathy (HP:0001644)1.63693263
111Pancreatic fibrosis (HP:0100732)1.62898842
112Difficulty running (HP:0009046)1.62575656
113Male infertility (HP:0003251)1.61746090
114Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.61606835
115Exercise-induced myalgia (HP:0003738)1.61414726
116Muscular dystrophy (HP:0003560)1.61288177
117True hermaphroditism (HP:0010459)1.59904993
118Absent frontal sinuses (HP:0002688)1.59134865
119Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.59052944
120Aplasia/Hypoplasia of the fibula (HP:0006492)1.58240850
121Preaxial hand polydactyly (HP:0001177)1.57880594
122Furrowed tongue (HP:0000221)1.57048419
123Decreased motor nerve conduction velocity (HP:0003431)1.55895725
124Neoplasm of head and neck (HP:0012288)1.55037317
125Esophageal neoplasm (HP:0100751)1.55037317
126Abnormal drinking behavior (HP:0030082)1.54058966
127Polydipsia (HP:0001959)1.54058966
128Onion bulb formation (HP:0003383)1.53937119
129Recurrent otitis media (HP:0000403)1.53276425
130Intellectual disability, moderate (HP:0002342)1.52986475
131Sclerocornea (HP:0000647)1.52936523
132Flat acetabular roof (HP:0003180)1.52931906
133Microglossia (HP:0000171)1.52714940
134Vaginal atresia (HP:0000148)1.48888686
135Short thorax (HP:0010306)1.47807251
136Abnormal glucose tolerance (HP:0001952)1.45114231
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.41562597
138Broad distal phalanx of finger (HP:0009836)1.41325521
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38141408
140Lip pit (HP:0100267)1.37206570
141Decreased circulating renin level (HP:0003351)1.37067279
142Limb-girdle muscle atrophy (HP:0003797)1.36500065
143Short ribs (HP:0000773)1.33054108
144Asplenia (HP:0001746)1.32384552
145Renal salt wasting (HP:0000127)1.29077029
146Abnormal biliary tract physiology (HP:0012439)1.25347282
147Bile duct proliferation (HP:0001408)1.25347282
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.19692383
149Hand muscle atrophy (HP:0009130)1.18299419
150Bifid scrotum (HP:0000048)1.16351207
151Hip dysplasia (HP:0001385)1.15828178
152Polycystic kidney dysplasia (HP:0000113)1.15293711
153Hypodontia (HP:0000668)1.14902071
154Optic nerve coloboma (HP:0000588)1.12304625
155Abnormality of the frontal sinuses (HP:0002687)1.11364806
156Abnormal pancreas size (HP:0012094)1.11174520
157Narrow chest (HP:0000774)1.10953091
158Self-mutilation (HP:0000742)1.10464947
159Aplasia/Hypoplasia of the sacrum (HP:0008517)1.10428989
160Hyponatremia (HP:0002902)1.10394081
161Retinitis pigmentosa (HP:0000510)1.09906892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.88618167
2EPHA25.04646215
3PDK44.49686396
4PDK34.49686396
5STK393.94739760
6PNCK3.42444365
7MST1R3.37820990
8TRPM73.36524142
9PDK23.26676257
10EPHB12.63735302
11TTN2.60148399
12MAPK152.60027382
13WNK42.46528548
14MAP3K122.05350708
15ICK1.98707867
16STK241.94908751
17TESK11.90654507
18MET1.89423835
19PINK11.88168720
20MYLK1.87654179
21NME11.82743363
22PTK2B1.76014087
23SMG11.72064676
24LMTK21.60272838
25MAP3K21.59451815
26MST41.51271289
27NTRK11.51179086
28WNK11.50196657
29CDK121.43881379
30ROCK21.41203239
31PKN11.40506687
32PHKG11.37445598
33PHKG21.37445598
34DMPK1.36776263
35LRRK21.36231905
36PDGFRA1.33271413
37PBK1.28910342
38EEF2K1.28183749
39NLK1.25295899
40OXSR11.23561705
41BCR1.23549376
42AKT31.23362045
43MAPKAPK51.17094955
44CAMK1G1.16042676
45PASK1.13668563
46MAPKAPK31.12797099
47TTK1.12003063
48MARK21.11877782
49STK381.09045974
50OBSCN1.06130291
51TESK21.04010682
52BRSK20.99304128
53CAMK2D0.98449845
54STK38L0.94289472
55MUSK0.89428871
56ROCK10.88593985
57PAK30.86593273
58MAP3K70.83159162
59RPS6KB20.82545548
60LIMK10.81230021
61TIE10.80877593
62PRKD30.80109523
63PRKCI0.77411566
64FGFR20.77152239
65PAK20.76139239
66FGFR40.75264967
67MELK0.73859817
68LATS10.72046036
69ILK0.70695925
70PRKAA20.69057124
71CSK0.68668066
72DYRK30.67590509
73MAP2K20.64414312
74PRKD10.64148662
75PDGFRB0.63283164
76NEK60.61359607
77PRKCE0.61242282
78ERBB40.61175606
79FGR0.61090683
80MAP2K40.61017145
81PAK40.60572254
82STK100.58538075
83MAP3K60.56986567
84MAP3K40.56970594
85TYK20.55357199
86MAP3K100.54393313
87MAP3K50.52989581
88ERBB20.52822305
89FER0.52741378
90PRKACB0.52619166
91CAMK2A0.52416425
92PTK20.52350700
93FGFR30.51536956
94EPHA30.51312715
95DAPK30.50780056
96EPHB20.50531013
97DDR20.49936866
98SGK30.49614398
99CAMKK20.49129127
100TSSK60.48955880
101TRIB30.48433078
102PLK10.47185204
103PTK60.46899796
104MAP3K30.46471119
105AURKA0.45212733
106CAMK1D0.43470957
107CAMK2G0.43201112
108STK160.42880388
109SGK20.42834061
110DYRK20.42170581
111RPS6KA20.41870748
112GSK3A0.41629644
113PIK3CA0.40817940
114MTOR0.39874548
115IKBKE0.38028511
116NEK20.37505597
117NME20.37314811
118RIPK10.35789491
119TNIK0.34923435
120PAK60.34834132
121PRKG10.34542209
122ERBB30.34495998
123GRK70.33594609
124MAPK120.33530392
125RET0.33416789
126CDC42BPA0.32345039
127BCKDK0.32078877
128SRC0.31416301
129SGK10.31398250
130CDK90.30824698
131TYRO30.30562058
132CAMK2B0.30171589
133CSNK1G10.29710626
134CSNK1D0.29467711
135PRKCQ0.28087345
136STK30.27948884
137CDK70.27429439
138BMX0.27012040
139MAPK70.26852954
140MOS0.26681622
141GRK10.26488087
142RPS6KA50.26111755
143CSNK1G30.25555701
144MAPKAPK20.25232674
145CSNK1A1L0.24922726
146CAMKK10.24907360
147DYRK1B0.24574157
148MAP2K70.24534298
149PRKD20.24402969
150SGK4940.24280728
151SGK2230.24280728
152RPS6KA40.24033110
153INSR0.23550844
154CHEK10.23024337
155PRKACA0.22963431
156CDK80.22352126
157WEE10.22238349
158AKT20.22113743
159MAP2K60.21940282
160AURKB0.21742379
161IGF1R0.21230365
162LATS20.19904935
163STK40.19302564
164PIM20.18956329
165FYN0.18850408
166NEK90.17677321
167ABL10.16030464

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.95470326
2Vitamin B6 metabolism_Homo sapiens_hsa007503.09834517
3beta-Alanine metabolism_Homo sapiens_hsa004102.96555706
4Propanoate metabolism_Homo sapiens_hsa006402.67731673
5Dilated cardiomyopathy_Homo sapiens_hsa054142.65402600
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.58619611
7Caffeine metabolism_Homo sapiens_hsa002322.56412767
8Cardiac muscle contraction_Homo sapiens_hsa042602.56327634
9Steroid biosynthesis_Homo sapiens_hsa001002.38536956
10Huntingtons disease_Homo sapiens_hsa050162.35332959
11Fatty acid elongation_Homo sapiens_hsa000622.34222310
12Oxidative phosphorylation_Homo sapiens_hsa001902.30762834
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.30269663
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04491973
15Parkinsons disease_Homo sapiens_hsa050121.89182716
16ABC transporters_Homo sapiens_hsa020101.88145636
17ECM-receptor interaction_Homo sapiens_hsa045121.83501287
18Pyruvate metabolism_Homo sapiens_hsa006201.82895646
19Ether lipid metabolism_Homo sapiens_hsa005651.80988068
20Dorso-ventral axis formation_Homo sapiens_hsa043201.76907230
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73109886
22Alzheimers disease_Homo sapiens_hsa050101.69314685
23Peroxisome_Homo sapiens_hsa041461.67019630
24Nucleotide excision repair_Homo sapiens_hsa034201.65552506
25Retinol metabolism_Homo sapiens_hsa008301.62178297
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55441950
27PPAR signaling pathway_Homo sapiens_hsa033201.52698449
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50371507
29Mineral absorption_Homo sapiens_hsa049781.45470486
30Fatty acid metabolism_Homo sapiens_hsa012121.44142168
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41850139
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39005851
33Focal adhesion_Homo sapiens_hsa045101.38394892
34N-Glycan biosynthesis_Homo sapiens_hsa005101.37911257
35Fatty acid degradation_Homo sapiens_hsa000711.36480730
36Ovarian steroidogenesis_Homo sapiens_hsa049131.36257455
37Glutathione metabolism_Homo sapiens_hsa004801.34483453
38Linoleic acid metabolism_Homo sapiens_hsa005911.34451707
39Viral myocarditis_Homo sapiens_hsa054161.31135899
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29572890
41Fatty acid biosynthesis_Homo sapiens_hsa000611.28790243
42Arachidonic acid metabolism_Homo sapiens_hsa005901.28083478
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26569967
44Circadian rhythm_Homo sapiens_hsa047101.25229757
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.22665589
46Hedgehog signaling pathway_Homo sapiens_hsa043401.21965913
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15399432
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13448920
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12707589
50Basal cell carcinoma_Homo sapiens_hsa052171.07989095
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06967225
52Malaria_Homo sapiens_hsa051441.05885312
53Sphingolipid metabolism_Homo sapiens_hsa006001.05323098
54p53 signaling pathway_Homo sapiens_hsa041151.03226978
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97554128
56Tight junction_Homo sapiens_hsa045300.93761588
57Rheumatoid arthritis_Homo sapiens_hsa053230.91621254
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90846016
59Adherens junction_Homo sapiens_hsa045200.90833449
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90183822
61Folate biosynthesis_Homo sapiens_hsa007900.86475224
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85720802
63Histidine metabolism_Homo sapiens_hsa003400.85360449
64Arginine and proline metabolism_Homo sapiens_hsa003300.84345788
65Axon guidance_Homo sapiens_hsa043600.83160686
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.82855801
67Inositol phosphate metabolism_Homo sapiens_hsa005620.81354755
68Collecting duct acid secretion_Homo sapiens_hsa049660.80983583
69Pancreatic cancer_Homo sapiens_hsa052120.79873517
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.78460132
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78321846
72Choline metabolism in cancer_Homo sapiens_hsa052310.78135423
73Phagosome_Homo sapiens_hsa041450.73937279
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72603953
75Colorectal cancer_Homo sapiens_hsa052100.72403333
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71743894
77Hepatitis C_Homo sapiens_hsa051600.71127770
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70656747
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.67998542
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67572154
81Sulfur metabolism_Homo sapiens_hsa009200.67345805
82Renal cell carcinoma_Homo sapiens_hsa052110.66539891
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.66246858
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.65724294
85Regulation of autophagy_Homo sapiens_hsa041400.65492571
86Proteoglycans in cancer_Homo sapiens_hsa052050.65489460
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65357061
88mTOR signaling pathway_Homo sapiens_hsa041500.65201677
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65091354
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64788534
91Tyrosine metabolism_Homo sapiens_hsa003500.64615109
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63789579
93Metabolic pathways_Homo sapiens_hsa011000.63705105
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62707441
95Protein export_Homo sapiens_hsa030600.62668847
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61981142
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61855441
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61663314
99Ras signaling pathway_Homo sapiens_hsa040140.61418846
100Pyrimidine metabolism_Homo sapiens_hsa002400.60625203
101Hippo signaling pathway_Homo sapiens_hsa043900.60146969
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59575441
103Wnt signaling pathway_Homo sapiens_hsa043100.59317680
104Vitamin digestion and absorption_Homo sapiens_hsa049770.58031471
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57750128
106Renin secretion_Homo sapiens_hsa049240.56622495
107Endometrial cancer_Homo sapiens_hsa052130.56267362
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54201900
109Chemical carcinogenesis_Homo sapiens_hsa052040.53798790
110Lysine degradation_Homo sapiens_hsa003100.53366543
111Notch signaling pathway_Homo sapiens_hsa043300.53031448
112Protein digestion and absorption_Homo sapiens_hsa049740.52773270
113Rap1 signaling pathway_Homo sapiens_hsa040150.52372248
114Starch and sucrose metabolism_Homo sapiens_hsa005000.52000432
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51583845
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50508236
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.50410252
118TGF-beta signaling pathway_Homo sapiens_hsa043500.50384690
119Pathways in cancer_Homo sapiens_hsa052000.50092033
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.49897769
121Fanconi anemia pathway_Homo sapiens_hsa034600.49875710
122Basal transcription factors_Homo sapiens_hsa030220.49809008
123Salmonella infection_Homo sapiens_hsa051320.49414619
124Base excision repair_Homo sapiens_hsa034100.49294896
125Carbon metabolism_Homo sapiens_hsa012000.48969212
126cAMP signaling pathway_Homo sapiens_hsa040240.48844827
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47620843
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46616009
129Cell cycle_Homo sapiens_hsa041100.46286088
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.45802053
131Gastric acid secretion_Homo sapiens_hsa049710.45351446
132Other glycan degradation_Homo sapiens_hsa005110.44885428
133Calcium signaling pathway_Homo sapiens_hsa040200.44788833
134Endocytosis_Homo sapiens_hsa041440.44472940
135Insulin resistance_Homo sapiens_hsa049310.43328575
136Amoebiasis_Homo sapiens_hsa051460.42873434
137HIF-1 signaling pathway_Homo sapiens_hsa040660.42866499
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42079503
139Lysosome_Homo sapiens_hsa041420.41024521
140Glycerolipid metabolism_Homo sapiens_hsa005610.40206752
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39523781
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37795145
143Estrogen signaling pathway_Homo sapiens_hsa049150.37639806
144Thyroid cancer_Homo sapiens_hsa052160.37297501
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36949784
146Non-homologous end-joining_Homo sapiens_hsa034500.36924138
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.36908889
148Small cell lung cancer_Homo sapiens_hsa052220.36623503
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35695604
150Prostate cancer_Homo sapiens_hsa052150.35577008
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.35549845
152Glucagon signaling pathway_Homo sapiens_hsa049220.35400375
153mRNA surveillance pathway_Homo sapiens_hsa030150.35283787
154Melanoma_Homo sapiens_hsa052180.35139334
155Thyroid hormone synthesis_Homo sapiens_hsa049180.34203708
156Apoptosis_Homo sapiens_hsa042100.33384377
157Galactose metabolism_Homo sapiens_hsa000520.33319635
158Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32190200
159Butanoate metabolism_Homo sapiens_hsa006500.31220273

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