TSSK1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.10062361
2* spermatid development (GO:0007286)8.67544122
3multicellular organism reproduction (GO:0032504)8.57377780
4binding of sperm to zona pellucida (GO:0007339)8.31590281
5sperm-egg recognition (GO:0035036)7.98802241
6regulation of phosphoprotein phosphatase activity (GO:0043666)7.56525695
7axonemal dynein complex assembly (GO:0070286)7.50741030
8sperm capacitation (GO:0048240)7.41561704
9reproduction (GO:0000003)7.22338124
10motile cilium assembly (GO:0044458)7.00295461
11plasma membrane fusion (GO:0045026)7.00096063
12cell-cell recognition (GO:0009988)6.78268330
13phosphatidylethanolamine biosynthetic process (GO:0006646)6.72522217
14chromosome condensation (GO:0030261)6.72348266
15spermatid nucleus differentiation (GO:0007289)6.56942691
16DNA packaging (GO:0006323)6.52318876
17negative regulation of inclusion body assembly (GO:0090084)6.50860690
18male meiosis (GO:0007140)6.46672515
19microtubule depolymerization (GO:0007019)6.42808261
20calcium ion-dependent exocytosis (GO:0017156)6.35901260
21cilium or flagellum-dependent cell motility (GO:0001539)6.32825634
22phosphatidylethanolamine metabolic process (GO:0046337)6.17946866
23protein polyglutamylation (GO:0018095)6.09214943
24nucleosome disassembly (GO:0006337)6.07721587
25protein-DNA complex disassembly (GO:0032986)6.07721587
26single fertilization (GO:0007338)6.02078372
27single strand break repair (GO:0000012)5.84196683
28protein targeting to Golgi (GO:0000042)5.76127936
29epithelial cilium movement (GO:0003351)5.73432288
30organic cation transport (GO:0015695)5.67875816
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.66623184
32spermatogenesis (GO:0007283)5.63988363
33male gamete generation (GO:0048232)5.61815204
34rRNA methylation (GO:0031167)5.52863014
35polyamine biosynthetic process (GO:0006596)5.52455141
36establishment of protein localization to Golgi (GO:0072600)5.50525726
37retrograde transport, vesicle recycling within Golgi (GO:0000301)5.32762727
38positive regulation of catecholamine secretion (GO:0033605)5.19478696
39gamete generation (GO:0007276)5.18198504
40microtubule polymerization or depolymerization (GO:0031109)5.09546035
41microtubule severing (GO:0051013)5.03738052
42* germ cell development (GO:0007281)5.03657020
43cilium movement (GO:0003341)4.82576065
44response to acidic pH (GO:0010447)4.71162029
45fertilization (GO:0009566)4.68008391
46* cellular process involved in reproduction in multicellular organism (GO:0022412)4.64929091
47sexual reproduction (GO:0019953)4.62560913
48regulation of cilium movement (GO:0003352)4.58884539
49centriole assembly (GO:0098534)4.57309759
50rRNA modification (GO:0000154)4.53344023
51regulation of inclusion body assembly (GO:0090083)4.52673759
52coenzyme catabolic process (GO:0009109)4.38788626
53response to pheromone (GO:0019236)4.37224129
54multicellular organismal reproductive process (GO:0048609)4.20098238
55ventricular system development (GO:0021591)4.17860744
56protein localization to Golgi apparatus (GO:0034067)4.05871197
57centriole replication (GO:0007099)4.02397401
58cellular ketone body metabolic process (GO:0046950)3.99123758
59regulation of Rab GTPase activity (GO:0032313)3.84856119
60positive regulation of Rab GTPase activity (GO:0032851)3.84856119
61histone exchange (GO:0043486)3.80874116
62cellular response to pH (GO:0071467)3.80718716
63male sex determination (GO:0030238)3.77444576
64regulation of transcription involved in cell fate commitment (GO:0060850)3.64247724
65cellular biogenic amine biosynthetic process (GO:0042401)3.62646134
66histone H3-K9 demethylation (GO:0033169)3.59507804
67mitochondrion degradation (GO:0000422)3.53582934
68amine biosynthetic process (GO:0009309)3.52342916
69potassium ion export (GO:0071435)3.51717786
70ketone body metabolic process (GO:1902224)3.50456756
71positive regulation of glycolytic process (GO:0045821)3.49720470
72synapsis (GO:0007129)3.49480780
73relaxation of smooth muscle (GO:0044557)3.46799381
74nucleus organization (GO:0006997)3.44869790
75regulation of oxidative stress-induced neuron death (GO:1903203)3.42247040
76activation of protein kinase B activity (GO:0032148)3.37129403
77RNA destabilization (GO:0050779)3.36710553
78cell recognition (GO:0008037)3.32182917
79cell wall macromolecule metabolic process (GO:0044036)3.31649802
80regulation of ARF GTPase activity (GO:0032312)3.31094839
81Leydig cell differentiation (GO:0033327)3.27529326
82acrosome assembly (GO:0001675)3.27249447
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25996035
84regulation of oxidative phosphorylation (GO:0002082)3.14121361
85cGMP-mediated signaling (GO:0019934)3.11290140
86detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.11274891
87regulation of centriole replication (GO:0046599)3.08134162
88cell wall macromolecule catabolic process (GO:0016998)3.07715282
89piRNA metabolic process (GO:0034587)3.07469853
90regulation of microtubule-based movement (GO:0060632)3.01494472
91oogenesis (GO:0048477)3.01100358
92regulation of phosphatase activity (GO:0010921)3.00159481
93cranial nerve morphogenesis (GO:0021602)2.98914046
94chromatin silencing (GO:0006342)2.96782195
95polyamine metabolic process (GO:0006595)2.95452826
96meiotic nuclear division (GO:0007126)2.94570129
97receptor recycling (GO:0001881)2.91583830
98seminiferous tubule development (GO:0072520)2.90845441
99sperm motility (GO:0030317)12.6222075
100acrosome reaction (GO:0007340)12.5105476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.50754891
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.06944006
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.07353408
4VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.02463880
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83982295
6EZH2_22144423_ChIP-Seq_EOC_Human2.67403407
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.50992865
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50992865
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46301446
10FUS_26573619_Chip-Seq_HEK293_Human2.33849203
11IGF1R_20145208_ChIP-Seq_DFB_Human2.28491274
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23182958
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20890556
14ARNT_22903824_ChIP-Seq_MCF-7_Human1.99971033
15NANOG_20526341_ChIP-Seq_ESCs_Human1.98104901
16RAC3_21632823_ChIP-Seq_H3396_Human1.93416154
17CTCF_27219007_Chip-Seq_Bcells_Human1.88172471
18* CBP_20019798_ChIP-Seq_JUKART_Human1.87640529
19* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87640529
20ERA_21632823_ChIP-Seq_H3396_Human1.83368333
21ER_23166858_ChIP-Seq_MCF-7_Human1.81701465
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.78744717
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76077060
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72112803
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.70991710
26SMC4_20622854_ChIP-Seq_HELA_Human1.68434854
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62451274
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61718826
29OCT4_20526341_ChIP-Seq_ESCs_Human1.61523373
30AR_21572438_ChIP-Seq_LNCaP_Human1.58513091
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57187337
32MYC_19829295_ChIP-Seq_ESCs_Human1.55200453
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.54689339
34* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53296462
35ERG_20517297_ChIP-Seq_VCAP_Human1.50175059
36AHR_22903824_ChIP-Seq_MCF-7_Human1.47059484
37EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.46828240
38TP53_18474530_ChIP-ChIP_U2OS_Human1.46149792
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.43777867
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42309176
41TBL1_22424771_ChIP-Seq_293T_Human1.41116180
42CTCF_20526341_ChIP-Seq_ESCs_Human1.38366844
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.37616560
44OCT1_27270436_Chip-Seq_PROSTATE_Human1.37589722
45AR_25329375_ChIP-Seq_VCAP_Human1.36795340
46GBX2_23144817_ChIP-Seq_PC3_Human1.33881959
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29661844
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29570361
49PHF8_20622854_ChIP-Seq_HELA_Human1.26992572
50P68_20966046_ChIP-Seq_HELA_Human1.25960184
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25466117
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24237085
53BCL6_27268052_Chip-Seq_Bcells_Human1.23857902
54P300_27268052_Chip-Seq_Bcells_Human1.23193777
55P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.23056849
56SMAD4_21799915_ChIP-Seq_A2780_Human1.21511677
57LXR_22292898_ChIP-Seq_THP-1_Human1.21191879
58HNFA_21074721_ChIP-Seq_CACO-2_Human1.20964620
59* P300_19829295_ChIP-Seq_ESCs_Human1.20688205
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.19651085
61CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18941204
62DROSHA_22980978_ChIP-Seq_HELA_Human1.18877637
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18866759
64RBPJ_21746931_ChIP-Seq_IB4_Human1.16714682
65E2F1_20622854_ChIP-Seq_HELA_Human1.16230964
66* TP63_22573176_ChIP-Seq_HFKS_Human1.16145740
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14165181
68* RUNX2_22187159_ChIP-Seq_PCA_Human1.13935073
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13934933
70NFYB_21822215_ChIP-Seq_K562_Human1.13850657
71BCOR_27268052_Chip-Seq_Bcells_Human1.12149051
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.11246490
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10154425
74ETV1_20927104_ChIP-Seq_GIST48_Human1.08751355
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08721056
76SPI1_20517297_ChIP-Seq_HL60_Human1.07986991
77SOX2_19829295_ChIP-Seq_ESCs_Human1.07799222
78NANOG_19829295_ChIP-Seq_ESCs_Human1.07799222
79PHF8_20622853_ChIP-Seq_HELA_Human1.07601739
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.05348303
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.04789235
82VDR_22108803_ChIP-Seq_LS180_Human1.04554543
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03361236
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02797650
85STAT3_23295773_ChIP-Seq_U87_Human1.01717624
86* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00790701
87TAF2_19829295_ChIP-Seq_ESCs_Human1.00430907
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98193566
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.97569615
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.96480103
91HOXB7_26014856_ChIP-Seq_BT474_Human0.96230970
92GF1_26923725_Chip-Seq_HPCs_Mouse0.96170970
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96152106
94P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95123263
95NFYA_21822215_ChIP-Seq_K562_Human0.95053542
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.93374928
97EZH2_27294783_Chip-Seq_ESCs_Mouse0.92700994
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92023723
99SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91582704
100OCT4_19829295_ChIP-Seq_ESCs_Human0.90327325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.62289458
2MP0001929_abnormal_gametogenesis4.09812193
3MP0005377_hearing/vestibular/ear_phenot3.69731776
4MP0003878_abnormal_ear_physiology3.69731776
5MP0003315_abnormal_perineum_morphology3.63631516
6MP0008004_abnormal_stomach_pH3.54824108
7MP0005670_abnormal_white_adipose3.14030852
8MP0002161_abnormal_fertility/fecundity2.52239329
9MP0002132_abnormal_respiratory_system2.39547138
10MP0002210_abnormal_sex_determination2.03509049
11MP0005410_abnormal_fertilization13.0441608
12MP0002160_abnormal_reproductive_system1.98078596
13MP0003718_maternal_effect1.89660941
14MP0005360_urolithiasis1.89007987
15MP0001348_abnormal_lacrimal_gland1.76947225
16MP0001145_abnormal_male_reproductive1.76038194
17MP0000678_abnormal_parathyroid_gland1.74168492
18MP0001984_abnormal_olfaction1.70637790
19MP0000653_abnormal_sex_gland1.61771370
20MP0003045_fibrosis1.50735220
21MP0005647_abnormal_sex_gland1.45187914
22MP0010386_abnormal_urinary_bladder1.41306576
23MP0001905_abnormal_dopamine_level1.33139507
24MP0001485_abnormal_pinna_reflex1.28934590
25MP0002249_abnormal_larynx_morphology1.28855367
26MP0003879_abnormal_hair_cell1.28081761
27MP0003646_muscle_fatigue1.25627985
28MP0009697_abnormal_copulation1.21695481
29MP0010368_abnormal_lymphatic_system1.18871022
30MP0002127_abnormal_cardiovascular_syste1.15708938
31MP0005395_other_phenotype1.13042274
32MP0005248_abnormal_Harderian_gland1.12955987
33MP0005394_taste/olfaction_phenotype1.11356794
34MP0005499_abnormal_olfactory_system1.11356794
35MP0001486_abnormal_startle_reflex1.06052405
36MP0008995_early_reproductive_senescence1.05446040
37MP0003136_yellow_coat_color1.05208553
38MP0001664_abnormal_digestion1.02007737
39MP0004859_abnormal_synaptic_plasticity1.00602793
40MP0002282_abnormal_trachea_morphology1.00053527
41MP0002138_abnormal_hepatobiliary_system0.95993389
42MP0002822_catalepsy0.92292169
43MP0005389_reproductive_system_phenotype0.87850374
44MP0005253_abnormal_eye_physiology0.87374617
45MP0005451_abnormal_body_composition0.87232871
46MP0001963_abnormal_hearing_physiology0.87122683
47MP0004085_abnormal_heartbeat0.85948969
48MP0001968_abnormal_touch/_nociception0.85766357
49MP0000538_abnormal_urinary_bladder0.85620282
50MP0005423_abnormal_somatic_nervous0.84241037
51MP0001188_hyperpigmentation0.83693547
52MP0004084_abnormal_cardiac_muscle0.81676059
53MP0003632_abnormal_nervous_system0.79849232
54MP0000534_abnormal_ureter_morphology0.77718186
55MP0005058_abnormal_lysosome_morphology0.77464815
56MP0000537_abnormal_urethra_morphology0.77311957
57MP0000026_abnormal_inner_ear0.76027613
58MP0001501_abnormal_sleep_pattern0.75511527
59MP0003936_abnormal_reproductive_system0.73559253
60MP0004036_abnormal_muscle_relaxation0.72698597
61MP0003631_nervous_system_phenotype0.71030607
62MP0004742_abnormal_vestibular_system0.70698536
63MP0009115_abnormal_fat_cell0.70129758
64MP0005379_endocrine/exocrine_gland_phen0.69223633
65MP0005187_abnormal_penis_morphology0.68533103
66MP0000470_abnormal_stomach_morphology0.66402027
67MP0001765_abnormal_ion_homeostasis0.66379373
68MP0001849_ear_inflammation0.66111203
69MP0005551_abnormal_eye_electrophysiolog0.65804021
70MP0002168_other_aberrant_phenotype0.62361128
71MP0001270_distended_abdomen0.62059896
72MP0006072_abnormal_retinal_apoptosis0.60953966
73MP0003011_delayed_dark_adaptation0.60931295
74MP0000049_abnormal_middle_ear0.60410738
75MP0000681_abnormal_thyroid_gland0.59076032
76MP0002272_abnormal_nervous_system0.58893708
77MP0000230_abnormal_systemic_arterial0.58677792
78MP0002067_abnormal_sensory_capabilities0.57348344
79MP0002229_neurodegeneration0.57118277
80MP0005595_abnormal_vascular_smooth0.55893286
81MP0002735_abnormal_chemical_nociception0.55756590
82MP0000955_abnormal_spinal_cord0.52306316
83MP0003633_abnormal_nervous_system0.51156790
84MP0005310_abnormal_salivary_gland0.50135928
85MP0004484_altered_response_of0.49017609
86MP0002557_abnormal_social/conspecific_i0.48577303
87MP0005646_abnormal_pituitary_gland0.46899233
88MP0005167_abnormal_blood-brain_barrier0.46061326
89MP0001529_abnormal_vocalization0.45814453
90MP0008789_abnormal_olfactory_epithelium0.43511135
91MP0003635_abnormal_synaptic_transmissio0.43386063
92MP0005409_darkened_coat_color0.43190060
93MP0005391_vision/eye_phenotype0.42995883
94MP0008877_abnormal_DNA_methylation0.41383767
95MP0004782_abnormal_surfactant_physiolog0.41154682
96MP0001879_abnormal_lymphatic_vessel0.40801527
97MP0002572_abnormal_emotion/affect_behav0.40557060
98MP0005166_decreased_susceptibility_to0.40282594
99MP0001919_abnormal_reproductive_system0.39755020
100MP0002234_abnormal_pharynx_morphology0.37322753

Predicted human phenotypes

RankGene SetZ-score
1Resting tremor (HP:0002322)7.29473981
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.14129016
3Absent/shortened dynein arms (HP:0200106)7.14129016
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.29904802
5Abnormal respiratory motile cilium physiology (HP:0012261)6.07348728
6Abnormal ciliary motility (HP:0012262)5.99489019
7Infertility (HP:0000789)5.40479970
8Abnormal respiratory epithelium morphology (HP:0012253)5.22033347
9Abnormal respiratory motile cilium morphology (HP:0005938)5.22033347
10Tubulointerstitial nephritis (HP:0001970)5.08003989
11Severe visual impairment (HP:0001141)4.98215234
12Abnormal sex determination (HP:0012244)4.87215683
13Sex reversal (HP:0012245)4.87215683
14Postural instability (HP:0002172)4.72469425
15Nasal polyposis (HP:0100582)4.63345631
16Chronic hepatic failure (HP:0100626)4.50034942
17Hypoplasia of the uterus (HP:0000013)4.08856625
18Abnormality of the nasal mucosa (HP:0000433)3.93245234
19Bony spicule pigmentary retinopathy (HP:0007737)3.77076901
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.63579285
21Rhinitis (HP:0012384)3.56436524
22Abnormality of macular pigmentation (HP:0008002)3.53742386
23Attenuation of retinal blood vessels (HP:0007843)3.49354402
24Asymmetric septal hypertrophy (HP:0001670)3.42273228
25Gonadal dysgenesis (HP:0000133)3.34394796
26Male infertility (HP:0003251)3.29254372
27Hyperkalemia (HP:0002153)3.24210016
28Abnormality of the columella (HP:0009929)3.23482876
29Colitis (HP:0002583)3.20999619
30Cerebellar dysplasia (HP:0007033)3.16953123
31Abnormal rod and cone electroretinograms (HP:0008323)3.11510768
32Aplasia/hypoplasia of the uterus (HP:0008684)3.02935735
33Male pseudohermaphroditism (HP:0000037)2.87904210
34Cone-rod dystrophy (HP:0000548)2.77998649
35Germ cell neoplasia (HP:0100728)2.76853497
36Chronic bronchitis (HP:0004469)2.75797658
37Reduced antithrombin III activity (HP:0001976)2.71933054
38Type II lissencephaly (HP:0007260)2.70617106
39Impulsivity (HP:0100710)2.69418326
40Bell-shaped thorax (HP:0001591)2.66098033
41Bronchiectasis (HP:0002110)2.61886717
42Hypoalphalipoproteinemia (HP:0003233)2.60588603
43Facial shape deformation (HP:0011334)2.57120756
44Potter facies (HP:0002009)2.57120756
45Abnormality of dental color (HP:0011073)2.54252508
46Renovascular hypertension (HP:0100817)2.52156276
47Occipital encephalocele (HP:0002085)2.51577928
48Renal dysplasia (HP:0000110)2.50946668
49Hypoplasia of the thymus (HP:0000778)2.48793185
50Menstrual irregularities (HP:0000858)2.41751487
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.41747357
52Congenital sensorineural hearing impairment (HP:0008527)2.41669260
53Sensory axonal neuropathy (HP:0003390)2.41363812
54Progressive sensorineural hearing impairment (HP:0000408)2.39917177
55Ventricular fibrillation (HP:0001663)2.39547455
56Atonic seizures (HP:0010819)2.38726955
57Retinal atrophy (HP:0001105)2.29713836
58Retinal dysplasia (HP:0007973)2.25584412
59Azoospermia (HP:0000027)2.24223276
60Polydipsia (HP:0001959)2.23905296
61Abnormal drinking behavior (HP:0030082)2.23905296
62Optic nerve hypoplasia (HP:0000609)2.22734596
63Abnormal spermatogenesis (HP:0008669)2.22490670
64Flattened epiphyses (HP:0003071)2.21923976
65Thoracolumbar scoliosis (HP:0002944)2.20948285
66Anterior segment dysgenesis (HP:0007700)2.17610013
67Abnormal urine output (HP:0012590)2.14828708
68Truncal obesity (HP:0001956)2.13651043
69Tubulointerstitial abnormality (HP:0001969)2.08052220
70Self-mutilation (HP:0000742)2.05987062
71Amelogenesis imperfecta (HP:0000705)2.03844886
72Facial hemangioma (HP:0000329)2.03734968
73Progressive cerebellar ataxia (HP:0002073)2.01641882
74Insulin-resistant diabetes mellitus (HP:0000831)2.01122746
75Inflammation of the large intestine (HP:0002037)1.97454701
76Hypoplastic ischia (HP:0003175)1.94476111
77Thoracic kyphosis (HP:0002942)1.92904012
78Portal hypertension (HP:0001409)1.91389576
79Recurrent corneal erosions (HP:0000495)1.88501530
80Abnormality of the hepatic vasculature (HP:0006707)1.86128678
81Abnormality of renal excretion (HP:0011036)1.85594905
82Abnormality of the ischium (HP:0003174)1.82621792
83Buphthalmos (HP:0000557)1.79498040
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79248843
85Generalized aminoaciduria (HP:0002909)1.78582544
86Polyuria (HP:0000103)1.78017731
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76572108
88Hyperuricemia (HP:0002149)1.75748547
89Increased purine levels (HP:0004368)1.75748547
90Gastrointestinal inflammation (HP:0004386)1.75363735
91Stage 5 chronic kidney disease (HP:0003774)1.74106192
92Photophobia (HP:0000613)1.73667290
93Abnormality of potassium homeostasis (HP:0011042)1.73031236
94Rhabdomyolysis (HP:0003201)1.72754436
95Urinary urgency (HP:0000012)1.71045914
96Atrial fibrillation (HP:0005110)1.67537906
97Nephronophthisis (HP:0000090)1.66872393
98Type II diabetes mellitus (HP:0005978)1.65778266
99Enlarged epiphyses (HP:0010580)1.60682152
100Myoglobinuria (HP:0002913)1.60086283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK18.78380348
2PLK45.39545394
3MARK34.48064602
4STK383.41477063
5TESK12.83460676
6TLK12.82649237
7STK38L2.64152633
8ZAK2.61527716
9MYLK2.36590825
10DDR22.23247866
11BRD42.17584778
12INSRR2.06470130
13MAPK152.01721883
14LATS11.96707221
15RPS6KA51.94568051
16MST1R1.88199237
17PNCK1.88126388
18NEK21.87477938
19PRKD31.81494308
20PLK21.77687151
21CAMK1G1.58347739
22MAP4K21.55663386
23LATS21.33286489
24PDPK11.31249101
25CDK31.23645702
26MAP3K91.22400579
27PDK11.16246744
28SGK4941.13951322
29SGK2231.13951322
30CDK121.06231312
31PIK3CG1.06074139
32MAP2K71.02837944
33WNK10.91668523
34PTK2B0.90674007
35NEK60.89328153
36PRKG20.78819279
37BMPR1B0.77165163
38ARAF0.75897722
39TIE10.74148633
40MAP3K10.71465284
41FRK0.69224232
42TYRO30.68195721
43AKT30.65802987
44DYRK1B0.65497374
45ROCK10.63231690
46PRKCQ0.63166989
47KSR20.61470377
48CAMK10.61412192
49BRAF0.61221999
50DYRK30.61154597
51PRKG10.60160182
52CDK70.56024269
53CDK140.52772459
54VRK10.51987562
55OBSCN0.51612636
56RPS6KA10.51059155
57CAMK1D0.49135534
58SIK20.44079009
59MTOR0.42172277
60CSNK1A1L0.42112054
61PAK20.40083465
62CDC42BPA0.40028515
63FGFR20.39218509
64PAK10.38638547
65PKN10.38176957
66MAP3K130.37591458
67RPS6KA20.35830139
68DYRK20.34881464
69MAPK10.33944754
70SGK20.31708063
71MAP3K20.31286986
72CSNK1G30.30841666
73ICK0.30030273
74MET0.28258436
75CDK50.27840937
76GSK3B0.27765782
77MOS0.23302794
78MAP3K80.22966026
79CDK10.19361725
80RET0.19282558
81ATM0.19207463
82SGK10.18284087
83CSNK1A10.17993435
84CSNK1G20.17226821
85ADRBK20.16969070
86CDK20.16809568
87WNK40.16626517
88CAMK40.15915521
89PRKAA20.15543105
90CSNK1G10.14702695
91MINK10.14683455
92RPS6KA30.14077844
93EEF2K0.13493758
94EGFR0.13196931
95MAPK80.12964110
96TGFBR10.12132001
97STK390.10188464
98RPS6KB10.08916531
99TNIK0.08043282
100PRKCB0.07949080

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051305.09799668
2Fatty acid biosynthesis_Homo sapiens_hsa000614.99378845
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.53120895
4Gap junction_Homo sapiens_hsa045403.77324200
5Olfactory transduction_Homo sapiens_hsa047403.57404757
6Hedgehog signaling pathway_Homo sapiens_hsa043402.84893544
7Nitrogen metabolism_Homo sapiens_hsa009102.49813341
8Butanoate metabolism_Homo sapiens_hsa006502.46970524
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.45693801
10Arginine biosynthesis_Homo sapiens_hsa002202.32912938
11Systemic lupus erythematosus_Homo sapiens_hsa053222.21812039
12Dorso-ventral axis formation_Homo sapiens_hsa043201.97998530
13Phagosome_Homo sapiens_hsa041451.92716949
14Apoptosis_Homo sapiens_hsa042101.81348717
15Alcoholism_Homo sapiens_hsa050341.78646105
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77091305
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.58344963
18Fatty acid degradation_Homo sapiens_hsa000711.47252588
19Phenylalanine metabolism_Homo sapiens_hsa003601.43677819
20Taste transduction_Homo sapiens_hsa047421.38875882
21PPAR signaling pathway_Homo sapiens_hsa033201.22250089
22Propanoate metabolism_Homo sapiens_hsa006401.21034127
23Fatty acid metabolism_Homo sapiens_hsa012121.08469380
24RNA transport_Homo sapiens_hsa030131.03218694
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.02066583
26Oocyte meiosis_Homo sapiens_hsa041140.99973545
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98429041
28Renin secretion_Homo sapiens_hsa049240.95227952
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94654442
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93742126
31Steroid hormone biosynthesis_Homo sapiens_hsa001400.93086410
32cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88918508
33Type II diabetes mellitus_Homo sapiens_hsa049300.86038472
34Calcium signaling pathway_Homo sapiens_hsa040200.78890842
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76872059
36Phototransduction_Homo sapiens_hsa047440.75178399
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71945181
38Gastric acid secretion_Homo sapiens_hsa049710.71663663
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71072157
40Glutathione metabolism_Homo sapiens_hsa004800.69892225
41Circadian entrainment_Homo sapiens_hsa047130.68880189
42Oxytocin signaling pathway_Homo sapiens_hsa049210.68163320
43Glucagon signaling pathway_Homo sapiens_hsa049220.68125805
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.65204405
45Tyrosine metabolism_Homo sapiens_hsa003500.64599167
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63484856
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63118037
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62044270
49Chemical carcinogenesis_Homo sapiens_hsa052040.61819204
50Salivary secretion_Homo sapiens_hsa049700.60804818
51Pyruvate metabolism_Homo sapiens_hsa006200.60567574
52Estrogen signaling pathway_Homo sapiens_hsa049150.59269073
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59174239
54mRNA surveillance pathway_Homo sapiens_hsa030150.56821944
55Synaptic vesicle cycle_Homo sapiens_hsa047210.55726415
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50923593
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50069149
58Protein digestion and absorption_Homo sapiens_hsa049740.49928873
59cAMP signaling pathway_Homo sapiens_hsa040240.49824045
60Purine metabolism_Homo sapiens_hsa002300.49269474
61Arginine and proline metabolism_Homo sapiens_hsa003300.46879530
62Basal transcription factors_Homo sapiens_hsa030220.46535398
63Inositol phosphate metabolism_Homo sapiens_hsa005620.45615502
64Endocytosis_Homo sapiens_hsa041440.45544696
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44693833
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43970439
67Glycerolipid metabolism_Homo sapiens_hsa005610.43803735
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43580602
69Type I diabetes mellitus_Homo sapiens_hsa049400.43563764
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42890535
71Long-term potentiation_Homo sapiens_hsa047200.42644119
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41187102
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40445732
74MAPK signaling pathway_Homo sapiens_hsa040100.39674950
75Circadian rhythm_Homo sapiens_hsa047100.39516179
76Morphine addiction_Homo sapiens_hsa050320.38506190
77ABC transporters_Homo sapiens_hsa020100.37802037
78ECM-receptor interaction_Homo sapiens_hsa045120.37682415
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36538253
80Glutamatergic synapse_Homo sapiens_hsa047240.36398908
81Antigen processing and presentation_Homo sapiens_hsa046120.36306659
82VEGF signaling pathway_Homo sapiens_hsa043700.34496757
83Influenza A_Homo sapiens_hsa051640.34185473
84Fanconi anemia pathway_Homo sapiens_hsa034600.33175425
85Tight junction_Homo sapiens_hsa045300.33147164
86Retinol metabolism_Homo sapiens_hsa008300.32952534
87Autoimmune thyroid disease_Homo sapiens_hsa053200.32349213
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31413906
89Allograft rejection_Homo sapiens_hsa053300.30256652
90Nicotine addiction_Homo sapiens_hsa050330.28232371
91Graft-versus-host disease_Homo sapiens_hsa053320.27644745
92Tryptophan metabolism_Homo sapiens_hsa003800.27190713
93Choline metabolism in cancer_Homo sapiens_hsa052310.25820129
94Selenocompound metabolism_Homo sapiens_hsa004500.25549465
95GABAergic synapse_Homo sapiens_hsa047270.24371895
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24339921
97Amphetamine addiction_Homo sapiens_hsa050310.23789051
98B cell receptor signaling pathway_Homo sapiens_hsa046620.23366009
99Cholinergic synapse_Homo sapiens_hsa047250.21470188
100Biosynthesis of amino acids_Homo sapiens_hsa012300.21423426

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