TSSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.44441843
2proteasome assembly (GO:0043248)4.71545885
3cullin deneddylation (GO:0010388)4.45748389
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.35341534
5protein deneddylation (GO:0000338)4.27927206
6chaperone-mediated protein transport (GO:0072321)4.20863943
7termination of RNA polymerase III transcription (GO:0006386)4.12733769
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.12733769
9purine nucleobase biosynthetic process (GO:0009113)4.12144471
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.07774793
11nucleobase biosynthetic process (GO:0046112)4.04237006
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.03980579
13regulation of cellular amino acid metabolic process (GO:0006521)4.00928206
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.96412818
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.95388213
16negative regulation of ligase activity (GO:0051352)3.93283884
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.93283884
18DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.86570749
19respiratory electron transport chain (GO:0022904)3.84489829
20peptidyl-histidine modification (GO:0018202)3.81280715
21DNA strand elongation involved in DNA replication (GO:0006271)3.81054837
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.79936529
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.79936529
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.78914837
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.78914837
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.78914837
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.78464675
287-methylguanosine mRNA capping (GO:0006370)3.78296121
29electron transport chain (GO:0022900)3.77510757
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76814570
31protein maturation by protein folding (GO:0022417)3.72195921
327-methylguanosine RNA capping (GO:0009452)3.70928143
33RNA capping (GO:0036260)3.70928143
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.70275140
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.68422447
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.68422447
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.66880037
38DNA strand elongation (GO:0022616)3.65102284
39DNA replication checkpoint (GO:0000076)3.64238461
40maturation of 5.8S rRNA (GO:0000460)3.58209723
41guanosine-containing compound biosynthetic process (GO:1901070)3.54259548
422-deoxyribonucleotide biosynthetic process (GO:0009265)3.54133625
43deoxyribose phosphate biosynthetic process (GO:0046385)3.54133625
44telomere maintenance via semi-conservative replication (GO:0032201)3.53944661
45ribosomal small subunit assembly (GO:0000028)3.53720200
46ribosomal small subunit biogenesis (GO:0042274)3.47950683
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.46481687
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44741435
49protein targeting to mitochondrion (GO:0006626)3.43843822
50ribosome biogenesis (GO:0042254)3.43395962
51viral mRNA export from host cell nucleus (GO:0046784)3.41394189
52formation of translation preinitiation complex (GO:0001731)3.41084919
53establishment of protein localization to mitochondrion (GO:0072655)3.39111301
54deoxyribonucleotide biosynthetic process (GO:0009263)3.36439002
55pseudouridine synthesis (GO:0001522)3.36394188
56DNA replication initiation (GO:0006270)3.32373731
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32069118
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.30068514
59spliceosomal snRNP assembly (GO:0000387)3.29712122
60positive regulation of ligase activity (GO:0051351)3.29253459
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.28497342
62NADH dehydrogenase complex assembly (GO:0010257)3.28497342
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28497342
64iron-sulfur cluster assembly (GO:0016226)3.26480900
65metallo-sulfur cluster assembly (GO:0031163)3.26480900
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24986462
67viral transcription (GO:0019083)3.22648293
68translation (GO:0006412)3.21847235
69cotranslational protein targeting to membrane (GO:0006613)3.21268663
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21183533
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.20433287
72proline biosynthetic process (GO:0006561)3.19231984
73protein targeting to ER (GO:0045047)3.17991285
74deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.17010188
75GDP-mannose metabolic process (GO:0019673)3.16076206
76G1/S transition of mitotic cell cycle (GO:0000082)3.15399919
77cell cycle G1/S phase transition (GO:0044843)3.15399919
78establishment of viral latency (GO:0019043)3.15340035
79GMP metabolic process (GO:0046037)3.15084387
80protein complex biogenesis (GO:0070271)3.14293603
81peptidyl-arginine omega-N-methylation (GO:0035247)3.12992547
82protein localization to endoplasmic reticulum (GO:0070972)3.12646969
83rRNA modification (GO:0000154)3.11969929
84protein localization to mitochondrion (GO:0070585)3.10735766
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.08197245
86respiratory chain complex IV assembly (GO:0008535)3.08123373
87positive regulation of mitochondrial fission (GO:0090141)3.08105802
88base-excision repair, AP site formation (GO:0006285)3.07811804
89GTP biosynthetic process (GO:0006183)3.07480896
90translational elongation (GO:0006414)3.06652523
91regulation of mitochondrial translation (GO:0070129)3.05562628
92nucleobase-containing small molecule interconversion (GO:0015949)3.05102582
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.04686500
94establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04245913
95ATP synthesis coupled proton transport (GO:0015986)3.03811895
96energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03811895
97oxidative phosphorylation (GO:0006119)3.01966875
98L-methionine salvage (GO:0071267)3.01393990
99L-methionine biosynthetic process (GO:0071265)3.01393990
100amino acid salvage (GO:0043102)3.01393990
101regulation of cellular amine metabolic process (GO:0033238)3.01369156
102translational termination (GO:0006415)2.99034120
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.98053880
104ribosomal large subunit biogenesis (GO:0042273)2.96957428
105DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95540345
106positive regulation of cell cycle arrest (GO:0071158)2.95231873
107ubiquinone biosynthetic process (GO:0006744)2.94820876
108telomere maintenance via recombination (GO:0000722)2.94791531
109mitochondrial respiratory chain complex assembly (GO:0033108)2.93955908
110ribonucleoprotein complex biogenesis (GO:0022613)2.93779605
111regulation of ligase activity (GO:0051340)2.93425715
112nucleotide-excision repair, DNA damage removal (GO:0000718)2.92187977
113DNA excision (GO:0044349)2.92187977
114UTP biosynthetic process (GO:0006228)2.91036151
115de novo protein folding (GO:0006458)2.90726221
116inner mitochondrial membrane organization (GO:0007007)2.90369401
117histone H2A acetylation (GO:0043968)2.90349042
118cytochrome complex assembly (GO:0017004)2.89561905
119mitochondrial RNA metabolic process (GO:0000959)2.89555944
120transcription-coupled nucleotide-excision repair (GO:0006283)2.89417449
121de novo posttranslational protein folding (GO:0051084)2.87121651
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.86057025
123translational initiation (GO:0006413)2.85590082
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85526038
125cellular component biogenesis (GO:0044085)2.85003163
126mitochondrial transport (GO:0006839)2.84532713
127rRNA processing (GO:0006364)2.83974283
128establishment of integrated proviral latency (GO:0075713)2.83555706
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82885377
130RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82885377
131maturation of SSU-rRNA (GO:0030490)2.82685267
132nuclear envelope reassembly (GO:0031468)2.82584833
133protein neddylation (GO:0045116)2.79955192
134protein-cofactor linkage (GO:0018065)2.77401319
135spliceosomal complex assembly (GO:0000245)2.74532812
136DNA damage response, detection of DNA damage (GO:0042769)2.73770577
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.73411612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.65350180
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.49009618
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.19353963
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.04735954
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.97375905
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.87571780
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.86342760
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.74357645
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.61743393
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.55499246
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17410876
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97920647
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89905310
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.84272322
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78707410
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75600553
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74821062
18* VDR_23849224_ChIP-Seq_CD4+_Human2.72371792
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69973010
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.50883223
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50668739
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50484683
23DCP1A_22483619_ChIP-Seq_HELA_Human2.38478329
24XRN2_22483619_ChIP-Seq_HELA_Human2.27526459
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26167463
26* GABP_19822575_ChIP-Seq_HepG2_Human2.25079885
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22781673
28* SRF_21415370_ChIP-Seq_HL-1_Mouse2.16784786
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15674576
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09330336
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.09274403
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08884606
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05111759
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95989934
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94088294
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91282107
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88756555
38* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86490998
39TTF2_22483619_ChIP-Seq_HELA_Human1.82859395
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80580664
41ELK1_19687146_ChIP-ChIP_HELA_Human1.76961415
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75756508
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.75428474
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73730643
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73416280
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70390943
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66397704
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66272006
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63240855
50CIITA_25753668_ChIP-Seq_RAJI_Human1.61566467
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55877127
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54344674
53ZNF263_19887448_ChIP-Seq_K562_Human1.49830204
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45412569
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44329197
56KDM5A_27292631_Chip-Seq_BREAST_Human1.38975788
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37169524
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34784232
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32827698
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31588862
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29338904
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26792703
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24051877
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.22697449
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17009063
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14147274
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13261239
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13230755
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13106119
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12156336
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10576084
72MYC_18940864_ChIP-ChIP_HL60_Human1.09133006
73* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08836892
74* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05403491
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.03666133
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02872857
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02651406
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02515019
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.01188256
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01101318
81TFEB_21752829_ChIP-Seq_HELA_Human0.99781190
82* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98023133
83SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97623198
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97329040
85IRF1_19129219_ChIP-ChIP_H3396_Human0.97170996
86* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95933685
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94330722
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93068964
89AR_21909140_ChIP-Seq_LNCAP_Human0.92759727
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91887540
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.91311784
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90765639
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90515285
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90182138
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89787798
96* SPI1_23547873_ChIP-Seq_NB4_Human0.87808139
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86677452
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86353036
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86041832
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84975759
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83174996
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82909245
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81999164
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.81650077
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81561247
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79943527
107IRF8_21731497_ChIP-ChIP_J774_Mouse0.77490910
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76740498
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.76160781
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75689578
111MYC_22102868_ChIP-Seq_BL_Human0.75528126
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74858167
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73551756
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73089888
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72810564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.36406959
2MP0003693_abnormal_embryo_hatching3.61016384
3MP0000372_irregular_coat_pigmentation3.16750847
4MP0004957_abnormal_blastocyst_morpholog3.14943430
5MP0010094_abnormal_chromosome_stability3.08180207
6MP0003111_abnormal_nucleus_morphology2.96793661
7MP0008877_abnormal_DNA_methylation2.72155977
8MP0001529_abnormal_vocalization2.65375931
9MP0004859_abnormal_synaptic_plasticity2.63076745
10MP0003077_abnormal_cell_cycle2.61387058
11MP0008058_abnormal_DNA_repair2.50804021
12MP0008057_abnormal_DNA_replication2.42037020
13MP0001968_abnormal_touch/_nociception2.28334923
14MP0002736_abnormal_nociception_after2.26585761
15MP0002822_catalepsy2.09289180
16MP0000015_abnormal_ear_pigmentation2.08185190
17MP0008875_abnormal_xenobiotic_pharmacok2.06518455
18MP0008260_abnormal_autophagy1.97988406
19MP0009046_muscle_twitch1.92366177
20MP0003635_abnormal_synaptic_transmissio1.88169398
21MP0008932_abnormal_embryonic_tissue1.88015681
22MP0002234_abnormal_pharynx_morphology1.87969396
23MP0003718_maternal_effect1.79948465
24MP0001984_abnormal_olfaction1.79440396
25MP0004270_analgesia1.76814117
26MP0002938_white_spotting1.75356605
27MP0002735_abnormal_chemical_nociception1.75283043
28MP0001905_abnormal_dopamine_level1.72636227
29MP0004147_increased_porphyrin_level1.69490351
30MP0008995_early_reproductive_senescence1.68358801
31MP0009745_abnormal_behavioral_response1.67607939
32MP0002064_seizures1.67171926
33MP0002734_abnormal_mechanical_nocicepti1.65210628
34MP0003123_paternal_imprinting1.56346990
35MP0002063_abnormal_learning/memory/cond1.54951544
36MP0003656_abnormal_erythrocyte_physiolo1.52965886
37MP0003786_premature_aging1.52476714
38MP0001188_hyperpigmentation1.51080180
39MP0002272_abnormal_nervous_system1.49132903
40MP0006276_abnormal_autonomic_nervous1.47037348
41MP0006036_abnormal_mitochondrial_physio1.44358400
42MP0002396_abnormal_hematopoietic_system1.43353841
43MP0003787_abnormal_imprinting1.41657427
44MP0002572_abnormal_emotion/affect_behav1.41598497
45MP0009333_abnormal_splenocyte_physiolog1.39509662
46MP0003879_abnormal_hair_cell1.38782192
47MP0008007_abnormal_cellular_replicative1.33908511
48MP0005084_abnormal_gallbladder_morpholo1.32498588
49MP0006035_abnormal_mitochondrial_morpho1.31118558
50MP0002876_abnormal_thyroid_physiology1.28972432
51MP0002132_abnormal_respiratory_system1.28070030
52MP0004142_abnormal_muscle_tone1.26124330
53MP0005075_abnormal_melanosome_morpholog1.25622964
54MP0001730_embryonic_growth_arrest1.25550153
55MP0005423_abnormal_somatic_nervous1.18445092
56MP0002751_abnormal_autonomic_nervous1.17670017
57MP0000350_abnormal_cell_proliferation1.14024147
58MP0002398_abnormal_bone_marrow1.13780869
59MP0002090_abnormal_vision1.13448926
60MP0001970_abnormal_pain_threshold1.13420787
61MP0004811_abnormal_neuron_physiology1.12979362
62MP0001440_abnormal_grooming_behavior1.12833271
63MP0003121_genomic_imprinting1.12691230
64MP0005671_abnormal_response_to1.12565745
65MP0006072_abnormal_retinal_apoptosis1.12324396
66MP0006292_abnormal_olfactory_placode1.10764718
67MP0002067_abnormal_sensory_capabilities1.10435699
68MP0003136_yellow_coat_color1.09299753
69MP0000313_abnormal_cell_death1.06476829
70MP0002733_abnormal_thermal_nociception1.04541778
71MP0005386_behavior/neurological_phenoty1.04498789
72MP0004924_abnormal_behavior1.04498789
73MP0001986_abnormal_taste_sensitivity1.03651530
74MP0003763_abnormal_thymus_physiology1.02459415
75MP0003806_abnormal_nucleotide_metabolis1.01177350
76MP0005408_hypopigmentation0.98902265
77MP0002095_abnormal_skin_pigmentation0.98591018
78MP0003186_abnormal_redox_activity0.96726952
79MP0000689_abnormal_spleen_morphology0.95807670
80MP0005646_abnormal_pituitary_gland0.95369119
81MP0009379_abnormal_foot_pigmentation0.94104571
82MP0003122_maternal_imprinting0.92141719
83MP0008872_abnormal_physiological_respon0.92026697
84MP0000358_abnormal_cell_content/0.91704003
85MP0002184_abnormal_innervation0.91621000
86MP0002722_abnormal_immune_system0.91404021
87MP0005499_abnormal_olfactory_system0.91341514
88MP0005394_taste/olfaction_phenotype0.91341514
89MP0000490_abnormal_crypts_of0.90904832
90MP0009697_abnormal_copulation0.90700442
91MP0002429_abnormal_blood_cell0.88391928
92MP0000566_synostosis0.88038482
93MP0008789_abnormal_olfactory_epithelium0.87907150
94MP0008961_abnormal_basal_metabolism0.87768458
95MP0001764_abnormal_homeostasis0.86884111
96MP0004742_abnormal_vestibular_system0.86060323
97MP0003329_amyloid_beta_deposits0.85849726
98MP0000703_abnormal_thymus_morphology0.85184052
99MP0002420_abnormal_adaptive_immunity0.85035675
100MP0002210_abnormal_sex_determination0.84793969
101MP0000716_abnormal_immune_system0.84567456
102MP0001819_abnormal_immune_cell0.84155859
103MP0002163_abnormal_gland_morphology0.83837326
104MP0002019_abnormal_tumor_incidence0.83599941
105MP0002177_abnormal_outer_ear0.83360875
106MP0002160_abnormal_reproductive_system0.83113501
107MP0001835_abnormal_antigen_presentation0.82575832
108MP0002653_abnormal_ependyma_morphology0.81142640
109MP0008873_increased_physiological_sensi0.80132033
110MP0001929_abnormal_gametogenesis0.79966503
111MP0005645_abnormal_hypothalamus_physiol0.79364798
112MP0005389_reproductive_system_phenotype0.78740151
113MP0002066_abnormal_motor_capabilities/c0.77768562
114MP0001919_abnormal_reproductive_system0.77749111
115MP0009785_altered_susceptibility_to0.77605605
116MP0002080_prenatal_lethality0.77381349
117MP0001346_abnormal_lacrimal_gland0.75850963
118MP0005000_abnormal_immune_tolerance0.75714434
119MP0001486_abnormal_startle_reflex0.75541976
120MP0002557_abnormal_social/conspecific_i0.75309818
121MP0004133_heterotaxia0.74176690
122MP0002102_abnormal_ear_morphology0.73985376
123MP0005410_abnormal_fertilization0.71858372
124MP0001727_abnormal_embryo_implantation0.71199711
125MP0001697_abnormal_embryo_size0.70883167
126MP0001293_anophthalmia0.70544843
127MP0010307_abnormal_tumor_latency0.70179233
128MP0000653_abnormal_sex_gland0.69751689
129MP0002161_abnormal_fertility/fecundity0.69499002
130MP0005501_abnormal_skin_physiology0.69481546
131MP0001145_abnormal_male_reproductive0.69452311
132MP0003698_abnormal_male_reproductive0.69385612
133MP0005332_abnormal_amino_acid0.69360995
134MP0000049_abnormal_middle_ear0.69226697
135MP0002075_abnormal_coat/hair_pigmentati0.65503416
136MP0005551_abnormal_eye_electrophysiolog0.64808041

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.45101761
2Acute necrotizing encephalopathy (HP:0006965)4.00195722
3Birth length less than 3rd percentile (HP:0003561)3.96012197
4Mitochondrial inheritance (HP:0001427)3.85881699
5Abnormal mitochondria in muscle tissue (HP:0008316)3.78700855
6Hepatocellular necrosis (HP:0001404)3.65928044
7Increased serum pyruvate (HP:0003542)3.64392447
8Abnormality of glycolysis (HP:0004366)3.64392447
9Increased CSF lactate (HP:0002490)3.51564433
10Abnormal number of erythroid precursors (HP:0012131)3.37162066
11Cerebral edema (HP:0002181)3.34101836
12Progressive macrocephaly (HP:0004481)3.14218221
13Abnormality of cells of the erythroid lineage (HP:0012130)3.14145478
14Increased serum lactate (HP:0002151)3.08762687
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05349096
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05349096
17Breast hypoplasia (HP:0003187)2.98922552
18Acute encephalopathy (HP:0006846)2.95429721
19Abnormal hair whorl (HP:0010721)2.95343638
20Hypokinesia (HP:0002375)2.94317136
21Hepatic necrosis (HP:0002605)2.89540804
22Hypoplasia of the capital femoral epiphysis (HP:0003090)2.87462812
23Abnormality of the heme biosynthetic pathway (HP:0010472)2.84706121
243-Methylglutaconic aciduria (HP:0003535)2.82141479
25Postnatal microcephaly (HP:0005484)2.82068778
26CNS hypomyelination (HP:0003429)2.78015269
27Increased hepatocellular lipid droplets (HP:0006565)2.76029804
28Ragged-red muscle fibers (HP:0003200)2.74159608
29Atonic seizures (HP:0010819)2.73910623
30Type I transferrin isoform profile (HP:0003642)2.72269062
31Aplastic anemia (HP:0001915)2.69752029
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.69718009
33Delusions (HP:0000746)2.63860133
34Abnormality of the anterior horn cell (HP:0006802)2.59030454
35Degeneration of anterior horn cells (HP:0002398)2.59030454
36Methylmalonic aciduria (HP:0012120)2.58956982
37Epileptic encephalopathy (HP:0200134)2.58200303
38Lactic acidosis (HP:0003128)2.54739575
39Poor suck (HP:0002033)2.53011384
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52113174
41Agnosia (HP:0010524)2.51586531
42Focal motor seizures (HP:0011153)2.47833271
43Oral leukoplakia (HP:0002745)2.46116778
44Type 2 muscle fiber atrophy (HP:0003554)2.42968852
45Respiratory failure (HP:0002878)2.41193896
46Hyperglycinemia (HP:0002154)2.41174341
47Generalized aminoaciduria (HP:0002909)2.40888859
48Exercise intolerance (HP:0003546)2.40426489
49Cholecystitis (HP:0001082)2.40362642
50Abnormal gallbladder physiology (HP:0012438)2.40362642
51Increased muscle lipid content (HP:0009058)2.38794596
52Lipid accumulation in hepatocytes (HP:0006561)2.38210823
53Abnormality of alanine metabolism (HP:0010916)2.38193117
54Hyperalaninemia (HP:0003348)2.38193117
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38193117
56Abnormality of the labia minora (HP:0012880)2.36061727
57Renal Fanconi syndrome (HP:0001994)2.34404724
58Abnormal protein N-linked glycosylation (HP:0012347)2.32850141
59Abnormal protein glycosylation (HP:0012346)2.32850141
60Abnormal glycosylation (HP:0012345)2.32850141
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32850141
62Neuroendocrine neoplasm (HP:0100634)2.32448963
63Dicarboxylic aciduria (HP:0003215)2.30629759
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30629759
65IgM deficiency (HP:0002850)2.28634087
66Tongue fasciculations (HP:0001308)2.27667945
67Entropion (HP:0000621)2.26403702
68Emotional lability (HP:0000712)2.25888217
69Lethargy (HP:0001254)2.24948313
70Unsteady gait (HP:0002317)2.22978168
71Muscle fiber atrophy (HP:0100295)2.22607288
72Methylmalonic acidemia (HP:0002912)2.22002514
73Exertional dyspnea (HP:0002875)2.21826888
74Reticulocytopenia (HP:0001896)2.21622316
75Retinal dysplasia (HP:0007973)2.20787519
76Leukodystrophy (HP:0002415)2.18636246
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17307643
78Rough bone trabeculation (HP:0100670)2.17093474
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.16856981
80Abnormality of the preputium (HP:0100587)2.13613457
81Progressive muscle weakness (HP:0003323)2.11178229
82Myokymia (HP:0002411)2.10622883
83Patellar aplasia (HP:0006443)2.10388945
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08996912
85Absent epiphyses (HP:0010577)2.08996912
86Bone marrow hypocellularity (HP:0005528)2.08898133
87CNS demyelination (HP:0007305)2.07088434
88Respiratory difficulties (HP:0002880)2.05712968
89Multiple enchondromatosis (HP:0005701)2.05413106
90Microretrognathia (HP:0000308)2.04575911
91B lymphocytopenia (HP:0010976)2.02710997
92Increased intramyocellular lipid droplets (HP:0012240)2.00057571
93Medulloblastoma (HP:0002885)1.98945383
94Severe visual impairment (HP:0001141)1.98658921
95Aplasia/Hypoplasia of the patella (HP:0006498)1.98106520
96Prominent metopic ridge (HP:0005487)1.97517184
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95730594
98Death in infancy (HP:0001522)1.95356621
99Horseshoe kidney (HP:0000085)1.94741570
100Tubulointerstitial nephritis (HP:0001970)1.94129073
101Delayed CNS myelination (HP:0002188)1.94097918
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93564574
103Pancytopenia (HP:0001876)1.91665873
104Microvesicular hepatic steatosis (HP:0001414)1.91638085
105Severe global developmental delay (HP:0011344)1.89537952
106Poikiloderma (HP:0001029)1.88224588
107Optic disc pallor (HP:0000543)1.88108882
108Medial flaring of the eyebrow (HP:0010747)1.87993378
109Cellular immunodeficiency (HP:0005374)1.85790011
110Pheochromocytoma (HP:0002666)1.85587497
111Abnormality of the metopic suture (HP:0005556)1.83606118
112Progressive microcephaly (HP:0000253)1.83224263
113Diminished movement (HP:0002374)1.82757683
114Premature graying of hair (HP:0002216)1.82093717
115Opisthotonus (HP:0002179)1.81950080
116Gliosis (HP:0002171)1.81066663
117Hyperventilation (HP:0002883)1.80915177
118Upper limb muscle weakness (HP:0003484)1.78054598
119Macrocytic anemia (HP:0001972)1.77487601
120Pallor (HP:0000980)1.76913561
121Severe combined immunodeficiency (HP:0004430)1.76177530
122Failure to thrive in infancy (HP:0001531)1.75873643
123Shoulder girdle muscle weakness (HP:0003547)1.75257630
124Carpal bone hypoplasia (HP:0001498)1.75063362
125Esotropia (HP:0000565)1.74535110
126Gait imbalance (HP:0002141)1.74528541
127Spastic paraparesis (HP:0002313)1.72923896
128Nephrogenic diabetes insipidus (HP:0009806)1.72847129
129Brushfield spots (HP:0001088)1.72616198
130Muscular hypotonia of the trunk (HP:0008936)1.71768475
131Muscle fibrillation (HP:0010546)1.71398617
132Choreoathetosis (HP:0001266)1.71320819
133Abnormality of the ileum (HP:0001549)1.70965635
134Delayed myelination (HP:0012448)1.70898739
135Congenital primary aphakia (HP:0007707)1.69840876
136Meckel diverticulum (HP:0002245)1.69267655
137Protruding tongue (HP:0010808)1.66116447
138Cleft eyelid (HP:0000625)1.66044774
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.65493645
140Colon cancer (HP:0003003)1.63319168
141Premature ovarian failure (HP:0008209)1.61772402
142Abnormality of B cell number (HP:0010975)1.61431660
143X-linked dominant inheritance (HP:0001423)1.61304291
144Ependymoma (HP:0002888)1.57387666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59968350
2VRK24.30499331
3CASK3.59032882
4CDK193.56319523
5MAP3K123.42397222
6STK163.07640418
7BCKDK2.90700522
8CCNB12.85666896
9TESK22.80671221
10EIF2AK12.75699771
11TSSK62.68743776
12DAPK12.35618122
13WEE12.30865207
14CDC72.14005608
15VRK11.83585410
16MAP4K21.78867432
17EIF2AK31.78803730
18SIK31.70750370
19DAPK21.57619652
20AKT31.50753206
21BRAF1.45722691
22TRIM281.42627492
23SRPK11.40180448
24TLK11.35746168
25NME21.33784683
26NEK11.29154206
27NUAK11.29020889
28MARK11.23428542
29LIMK11.22553628
30IRAK41.22094635
31SCYL21.20216305
32PLK41.19952990
33CSNK1G21.19334003
34BRSK11.18287599
35PIM21.17785059
36MAP2K71.17636871
37ARAF1.16569813
38OXSR11.13734467
39PRPF4B1.13133522
40TESK11.12229448
41DYRK31.10534343
42MINK11.08238101
43PLK31.06851913
44CSNK1A1L1.05441664
45AURKA1.05246644
46EPHA41.03378361
47NME11.03363864
48RPS6KA41.01234127
49PLK21.00861130
50PDK21.00560697
51RPS6KA50.98761725
52EPHA20.98588660
53DYRK20.97871664
54PAK60.97039387
55PLK10.97013873
56BCR0.93227241
57ACVR1B0.92781020
58PASK0.92294186
59ABL20.89922286
60PHKG20.89381662
61PHKG10.89381662
62BLK0.87966342
63MAPK130.86229517
64CDK180.86078016
65CSNK1G10.83701630
66TNIK0.82419059
67MAP4K10.82163826
68MAP3K110.79080101
69RAF10.79070706
70BRSK20.77512123
71CDK70.76736148
72DAPK30.76277850
73AKT20.75672797
74CDK150.75075623
75MAPKAPK30.74640168
76TAOK30.72099459
77CLK10.71449934
78CDK11A0.71199221
79CDK140.69790318
80ATR0.68375544
81MKNK20.67727708
82RIPK40.67678336
83CDK80.66920040
84MKNK10.66549132
85SYK0.66222782
86YES10.64751366
87NTRK30.63634759
88MST40.60795831
89SMG10.60565392
90IRAK30.60488635
91CHEK10.60305945
92KSR10.59342736
93AURKB0.58623666
94MYLK0.56733362
95FES0.56339217
96TXK0.55496481
97ADRBK20.54763174
98PRKCG0.52671524
99ILK0.52579814
100KDR0.52186194
101UHMK10.51917235
102CAMKK20.50218679
103PAK10.49625401
104GRK60.49372798
105MAP3K50.48971269
106TAOK20.47899334
107ZAK0.47406123
108CAMK2G0.47092831
109CDK20.45962081
110CSNK2A10.45823711
111PNCK0.45513964
112CSNK2A20.45497305
113STK40.43396399
114CSNK1E0.42954810
115LMTK20.41869978
116MUSK0.41005899
117ATM0.40846996
118TTK0.40496068
119CHEK20.39935734
120PRKCI0.39826102
121LRRK20.39624160
122PKN10.38099266
123CDK50.37846853
124PDK40.37626280
125PDK30.37626280
126RPS6KB20.37546171
127PAK40.36849884
128DYRK1B0.36545906
129ALK0.35528793
130PRKD30.35293938
131ZAP700.35193747
132BMPR1B0.34038831
133NEK20.33517602
134PBK0.32831153
135CAMK2B0.32508342
136CSNK1G30.32404179
137IRAK20.32156358
138LYN0.31069672
139CDK10.31068650
140MAP3K40.29049767
141MAP3K80.29029400

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.38543785
2DNA replication_Homo sapiens_hsa030303.78845969
3RNA polymerase_Homo sapiens_hsa030203.70896821
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08351626
5Mismatch repair_Homo sapiens_hsa034302.94359340
6Ribosome_Homo sapiens_hsa030102.89135544
7Oxidative phosphorylation_Homo sapiens_hsa001902.83735687
8Spliceosome_Homo sapiens_hsa030402.64273321
9Pyrimidine metabolism_Homo sapiens_hsa002402.45122806
10Base excision repair_Homo sapiens_hsa034102.42683181
11Parkinsons disease_Homo sapiens_hsa050122.34318177
12RNA transport_Homo sapiens_hsa030132.17978494
13Fatty acid elongation_Homo sapiens_hsa000622.15562147
14Collecting duct acid secretion_Homo sapiens_hsa049662.13328184
15Homologous recombination_Homo sapiens_hsa034402.11470067
16Synaptic vesicle cycle_Homo sapiens_hsa047212.03531233
17Nucleotide excision repair_Homo sapiens_hsa034202.03209881
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97261445
19Huntingtons disease_Homo sapiens_hsa050161.92636651
20Protein export_Homo sapiens_hsa030601.92038169
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91985070
22Basal transcription factors_Homo sapiens_hsa030221.74419642
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67513919
24Cell cycle_Homo sapiens_hsa041101.60056538
25Non-homologous end-joining_Homo sapiens_hsa034501.56225136
26Purine metabolism_Homo sapiens_hsa002301.53098020
27Alzheimers disease_Homo sapiens_hsa050101.51905523
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41868768
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37472755
30Vibrio cholerae infection_Homo sapiens_hsa051101.35673187
31Fanconi anemia pathway_Homo sapiens_hsa034601.35254643
32RNA degradation_Homo sapiens_hsa030181.27338598
33Steroid biosynthesis_Homo sapiens_hsa001001.24300210
34Epstein-Barr virus infection_Homo sapiens_hsa051691.17625505
35Glutathione metabolism_Homo sapiens_hsa004801.11004918
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08993723
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08896315
38Nicotine addiction_Homo sapiens_hsa050331.06838722
39Regulation of autophagy_Homo sapiens_hsa041401.06139991
40Sulfur metabolism_Homo sapiens_hsa009201.03907768
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03712275
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03017779
43Oocyte meiosis_Homo sapiens_hsa041141.02717818
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00088828
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96015347
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93047060
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90911039
48Peroxisome_Homo sapiens_hsa041460.90878919
49N-Glycan biosynthesis_Homo sapiens_hsa005100.89084412
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84139233
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82977082
52mRNA surveillance pathway_Homo sapiens_hsa030150.82298481
53Vitamin B6 metabolism_Homo sapiens_hsa007500.82197705
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.81895265
55Phagosome_Homo sapiens_hsa041450.81576872
56Pentose phosphate pathway_Homo sapiens_hsa000300.81088653
57One carbon pool by folate_Homo sapiens_hsa006700.79503809
58Pyruvate metabolism_Homo sapiens_hsa006200.76175982
59Propanoate metabolism_Homo sapiens_hsa006400.74830731
60Primary immunodeficiency_Homo sapiens_hsa053400.74697843
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72963006
62Rheumatoid arthritis_Homo sapiens_hsa053230.71457677
63Fatty acid metabolism_Homo sapiens_hsa012120.70353956
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.69825350
65Long-term potentiation_Homo sapiens_hsa047200.65381031
66Fructose and mannose metabolism_Homo sapiens_hsa000510.64991348
67p53 signaling pathway_Homo sapiens_hsa041150.64106861
68Alcoholism_Homo sapiens_hsa050340.63639394
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63319932
70Systemic lupus erythematosus_Homo sapiens_hsa053220.62554187
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62083117
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.61747254
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60331281
74Cardiac muscle contraction_Homo sapiens_hsa042600.58981961
75Olfactory transduction_Homo sapiens_hsa047400.57476280
76Antigen processing and presentation_Homo sapiens_hsa046120.54609264
77Legionellosis_Homo sapiens_hsa051340.51508413
78Biosynthesis of amino acids_Homo sapiens_hsa012300.50629666
79Type I diabetes mellitus_Homo sapiens_hsa049400.47252288
80Shigellosis_Homo sapiens_hsa051310.47096708
81Amphetamine addiction_Homo sapiens_hsa050310.47085514
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46440758
83Butanoate metabolism_Homo sapiens_hsa006500.44215487
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43297020
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42631516
86Selenocompound metabolism_Homo sapiens_hsa004500.42562712
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42301174
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42220229
89Phenylalanine metabolism_Homo sapiens_hsa003600.42008328
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40098763
91Metabolic pathways_Homo sapiens_hsa011000.39869570
92Sulfur relay system_Homo sapiens_hsa041220.37896114
93Folate biosynthesis_Homo sapiens_hsa007900.36448587
94Thyroid cancer_Homo sapiens_hsa052160.35658571
95Dopaminergic synapse_Homo sapiens_hsa047280.33553444
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33215737
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32842444
98Caffeine metabolism_Homo sapiens_hsa002320.32722161
99Arginine and proline metabolism_Homo sapiens_hsa003300.30654082
100Carbon metabolism_Homo sapiens_hsa012000.29355818
101Other glycan degradation_Homo sapiens_hsa005110.28890941
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28800870
103Viral carcinogenesis_Homo sapiens_hsa052030.27952803
104Morphine addiction_Homo sapiens_hsa050320.27870271
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27058917
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26614310
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26570186
108GABAergic synapse_Homo sapiens_hsa047270.26026762
109Phototransduction_Homo sapiens_hsa047440.20973201
110Tyrosine metabolism_Homo sapiens_hsa003500.20293360
111Serotonergic synapse_Homo sapiens_hsa047260.20036367
112Asthma_Homo sapiens_hsa053100.19739000
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.19483338
114Apoptosis_Homo sapiens_hsa042100.17380395
115Circadian entrainment_Homo sapiens_hsa047130.17374344
116Galactose metabolism_Homo sapiens_hsa000520.16688858
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16534869
118Colorectal cancer_Homo sapiens_hsa052100.16068571
119Long-term depression_Homo sapiens_hsa047300.14313781
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13324578
121Taste transduction_Homo sapiens_hsa047420.13164449
122Hematopoietic cell lineage_Homo sapiens_hsa046400.13101202
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12943749
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12929337
125Sphingolipid metabolism_Homo sapiens_hsa006000.12907489
126Herpes simplex infection_Homo sapiens_hsa051680.12898173
127Arginine biosynthesis_Homo sapiens_hsa002200.11631800
128T cell receptor signaling pathway_Homo sapiens_hsa046600.11601482
129Graft-versus-host disease_Homo sapiens_hsa053320.11175108
130Lysosome_Homo sapiens_hsa041420.08834497

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