TSPYL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.46536929
2neuron cell-cell adhesion (GO:0007158)5.38738180
3synaptic vesicle exocytosis (GO:0016079)5.15096592
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.13915929
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12548597
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.11000761
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.01241689
8presynaptic membrane assembly (GO:0097105)5.00389686
9presynaptic membrane organization (GO:0097090)4.81189831
10protein localization to synapse (GO:0035418)4.80129802
11neurotransmitter-gated ion channel clustering (GO:0072578)4.77382632
12glutamate secretion (GO:0014047)4.74823689
13regulation of glutamate receptor signaling pathway (GO:1900449)4.72753095
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67792976
15regulation of synaptic vesicle exocytosis (GO:2000300)4.67584365
16postsynaptic membrane organization (GO:0001941)4.30927644
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.29783117
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.20478535
19regulation of synaptic vesicle transport (GO:1902803)4.16664283
20neuronal action potential propagation (GO:0019227)4.16101886
21synaptic transmission, glutamatergic (GO:0035249)4.13012144
22neuron-neuron synaptic transmission (GO:0007270)4.12469405
23glutamate receptor signaling pathway (GO:0007215)4.04188287
24epithelial cell fate commitment (GO:0072148)4.01791400
25neurotransmitter secretion (GO:0007269)4.01613149
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85214256
27long-term synaptic potentiation (GO:0060291)3.80564963
28neuron recognition (GO:0008038)3.79684578
29startle response (GO:0001964)3.75190107
30locomotory exploration behavior (GO:0035641)3.73798996
31synaptic vesicle maturation (GO:0016188)3.73412687
32negative regulation of dendrite morphogenesis (GO:0050774)3.72190528
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.71275976
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70192679
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68395239
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65564309
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61016513
38positive regulation of synapse maturation (GO:0090129)3.58981571
39positive regulation of synapse assembly (GO:0051965)3.56056750
40regulation of neuronal synaptic plasticity (GO:0048168)3.55442760
41regulation of postsynaptic membrane potential (GO:0060078)3.51956810
42regulation of synaptic transmission, glutamatergic (GO:0051966)3.48695603
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45291915
44response to histamine (GO:0034776)3.43200958
45exploration behavior (GO:0035640)3.42698323
46regulation of glutamate secretion (GO:0014048)3.39605651
47female mating behavior (GO:0060180)3.39170595
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38268873
49mechanosensory behavior (GO:0007638)3.36280992
50gamma-aminobutyric acid transport (GO:0015812)3.36055783
51cerebellar granule cell differentiation (GO:0021707)3.35319806
52axonal fasciculation (GO:0007413)3.35193087
53positive regulation of protein autophosphorylation (GO:0031954)3.33182036
54regulation of neurotransmitter secretion (GO:0046928)3.31506671
55behavioral response to cocaine (GO:0048148)3.29768345
56neurotransmitter transport (GO:0006836)3.27693859
57regulation of synaptic plasticity (GO:0048167)3.27525317
58positive regulation of membrane potential (GO:0045838)3.24850127
59regulation of female receptivity (GO:0045924)3.23540018
60striatum development (GO:0021756)3.22378406
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22306777
62positive regulation of neurotransmitter transport (GO:0051590)3.20857716
63positive regulation of neurotransmitter secretion (GO:0001956)3.20025024
64transferrin transport (GO:0033572)3.19793615
65keratinocyte development (GO:0003334)3.19567221
66positive regulation of meiosis (GO:0045836)3.19378682
67negative regulation of dendrite development (GO:2000171)3.19321803
68proline transport (GO:0015824)3.18512909
69detection of calcium ion (GO:0005513)3.17862928
70regulation of type B pancreatic cell apoptotic process (GO:2000674)3.17030955
71ATP hydrolysis coupled proton transport (GO:0015991)3.14614762
72energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14614762
73negative regulation of hormone biosynthetic process (GO:0032353)3.14535286
74auditory behavior (GO:0031223)3.13600356
75regulation of synapse structural plasticity (GO:0051823)3.13548228
76synapse assembly (GO:0007416)3.12802446
77synaptic vesicle endocytosis (GO:0048488)3.12605749
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12058209
79regulation of synapse maturation (GO:0090128)3.10403657
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10332470
81positive regulation of macroautophagy (GO:0016239)3.07259515
82transmission of nerve impulse (GO:0019226)3.06256681
83long-term memory (GO:0007616)3.04663153
84membrane depolarization (GO:0051899)3.03846800
85behavioral defense response (GO:0002209)3.03726400
86behavioral fear response (GO:0001662)3.03726400
87regulation of neurotransmitter transport (GO:0051588)3.02944157
88positive regulation of synaptic transmission (GO:0050806)2.99613141
89regulation of synaptic transmission, GABAergic (GO:0032228)2.99192943
90insulin secretion (GO:0030073)2.98608488
91calcium ion-dependent exocytosis (GO:0017156)2.98554099
92synaptic transmission (GO:0007268)2.96945710
93ferric iron transport (GO:0015682)2.96500622
94trivalent inorganic cation transport (GO:0072512)2.96500622
95learning (GO:0007612)2.95985165
96dendrite development (GO:0016358)2.95928586
97regulation of neurotransmitter levels (GO:0001505)2.95383649
98positive regulation of meiotic cell cycle (GO:0051446)2.95362174
99protein localization to cilium (GO:0061512)2.95047158
100regulation of synapse assembly (GO:0051963)2.94499619
101membrane depolarization during action potential (GO:0086010)2.94056598
102fear response (GO:0042596)2.94019290
103cerebellar Purkinje cell differentiation (GO:0021702)2.93276676
104innervation (GO:0060384)2.93178218
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92842873
106regulation of protein kinase A signaling (GO:0010738)2.90899500
107regulation of vesicle fusion (GO:0031338)2.89155110
108response to auditory stimulus (GO:0010996)2.86247025
109negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85621580
110regulation of synaptic transmission (GO:0050804)2.85581964
111regulation of dendritic spine morphogenesis (GO:0061001)2.80117880
112synapsis (GO:0007129)2.74785660
113urinary tract smooth muscle contraction (GO:0014848)2.72143906
114negative regulation of activin receptor signaling pathway (GO:0032926)2.66461939
115regulation of dendritic spine development (GO:0060998)2.63288301
116positive regulation of glycolytic process (GO:0045821)2.62048749
117pharyngeal system development (GO:0060037)2.61402664
118positive regulation of actin filament depolymerization (GO:0030836)2.59991964
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59744150
120negative regulation of hormone metabolic process (GO:0032351)2.58729812
121inositol phosphate catabolic process (GO:0071545)2.58596427
122piRNA metabolic process (GO:0034587)2.55971968
123lactate metabolic process (GO:0006089)2.51913409
124chemosensory behavior (GO:0007635)2.50835332
125regulation of meiosis I (GO:0060631)2.50092884
126glycerophospholipid catabolic process (GO:0046475)2.43213615
127positive regulation of response to nutrient levels (GO:0032109)2.40076864
128positive regulation of response to extracellular stimulus (GO:0032106)2.40076864
129COPII vesicle coating (GO:0048208)2.36884673
130regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.32550428
131response to pheromone (GO:0019236)2.32427822
132retrograde transport, vesicle recycling within Golgi (GO:0000301)2.29230054
133outflow tract septum morphogenesis (GO:0003148)2.27705414
134cardiac right ventricle morphogenesis (GO:0003215)2.27465185
135glandular epithelial cell differentiation (GO:0002067)2.26616236
136regulation of cardioblast proliferation (GO:0003264)2.24032161
137regulation of secondary heart field cardioblast proliferation (GO:0003266)2.24032161
138central nervous system neuron axonogenesis (GO:0021955)2.23883165
139protein targeting to Golgi (GO:0000042)2.23537481
140regulation of Rap GTPase activity (GO:0032317)2.22354098
141positive regulation of nitric-oxide synthase activity (GO:0051000)2.22070772
142regulation of neurotransmitter uptake (GO:0051580)2.21118648
143positive regulation of glycogen biosynthetic process (GO:0045725)2.19086065
144dendritic spine morphogenesis (GO:0060997)2.18462094
145establishment of nucleus localization (GO:0040023)2.17852582
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.16625289
147establishment of protein localization to Golgi (GO:0072600)2.16495171
148long term synaptic depression (GO:0060292)2.16366572
149cellular ketone body metabolic process (GO:0046950)2.15160395
150Golgi to endosome transport (GO:0006895)2.14916870
151dentate gyrus development (GO:0021542)2.14517333
152activin receptor signaling pathway (GO:0032924)2.14071794
153nitric oxide mediated signal transduction (GO:0007263)2.13677684
154endocrine pancreas development (GO:0031018)2.12528364
155parental behavior (GO:0060746)2.12461243
156coronary vasculature morphogenesis (GO:0060977)2.12384988
157positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.11516173
158brain morphogenesis (GO:0048854)2.10854232
159cochlea development (GO:0090102)2.10709037
160macroautophagy (GO:0016236)2.09570818
161phosphorylated carbohydrate dephosphorylation (GO:0046838)2.08569383
162inositol phosphate dephosphorylation (GO:0046855)2.08569383
163maternal behavior (GO:0042711)2.07521661
164embryonic foregut morphogenesis (GO:0048617)2.07312073
165regulation of protein glycosylation (GO:0060049)2.05740855
166atrial septum morphogenesis (GO:0060413)2.05674000
167positive regulation of protein depolymerization (GO:1901881)2.05126128
168regulation of male gonad development (GO:2000018)2.03931358
169acrosome reaction (GO:0007340)2.02283237
170Leydig cell differentiation (GO:0033327)2.00917358
171DNA methylation involved in gamete generation (GO:0043046)2.00396189
172regulation of clathrin-mediated endocytosis (GO:2000369)1.98912585
173apical protein localization (GO:0045176)1.97882286
174desmosome organization (GO:0002934)1.97746239
175limb bud formation (GO:0060174)1.97679091
176regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.97058883
177calcium ion import (GO:0070509)1.95673689
178neuromuscular process controlling posture (GO:0050884)1.93664125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96664807
2GBX2_23144817_ChIP-Seq_PC3_Human4.43443707
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38634424
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91585097
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73648486
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71824279
7TAF15_26573619_Chip-Seq_HEK293_Human2.65686165
8REST_21632747_ChIP-Seq_MESCs_Mouse2.48127458
9* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.44506803
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44448229
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.38948217
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32910369
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31130908
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31130908
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29738575
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29046517
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27832919
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26121361
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21397301
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20543566
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.20270986
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17802361
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13276061
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09515267
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09432714
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05995165
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.00027573
28P300_19829295_ChIP-Seq_ESCs_Human1.95129818
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95027218
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.94788986
31SMAD4_21799915_ChIP-Seq_A2780_Human1.94189648
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.92702281
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92417651
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91193296
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.90753490
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.90390071
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80521561
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77392136
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72064658
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70958624
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.70743397
42RNF2_27304074_Chip-Seq_NSC_Mouse1.67788593
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.66193443
44AR_21572438_ChIP-Seq_LNCaP_Human1.65468431
45DROSHA_22980978_ChIP-Seq_HELA_Human1.65382651
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65375994
47VDR_22108803_ChIP-Seq_LS180_Human1.63724686
48FUS_26573619_Chip-Seq_HEK293_Human1.61172629
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.58156045
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56577473
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53702336
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52813842
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.46487374
54* EP300_21415370_ChIP-Seq_HL-1_Mouse1.44889686
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.44107479
56AR_25329375_ChIP-Seq_VCAP_Human1.43373350
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42969916
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41385415
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40204836
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38923616
61* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37271575
62ZNF274_21170338_ChIP-Seq_K562_Hela1.37039158
63* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35625578
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34288601
65STAT3_23295773_ChIP-Seq_U87_Human1.31037352
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30446585
67IGF1R_20145208_ChIP-Seq_DFB_Human1.29592610
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28434161
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27970615
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27936430
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27051364
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25778208
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25421611
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.24553972
75* TCF4_23295773_ChIP-Seq_U87_Human1.24037601
76ER_23166858_ChIP-Seq_MCF-7_Human1.23474434
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.22853295
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22481769
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19389707
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.19334801
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18589898
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17974158
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16659835
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.16187637
85JUN_21703547_ChIP-Seq_K562_Human1.15506244
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.15427332
87AHR_22903824_ChIP-Seq_MCF-7_Human1.15326337
88* CJUN_26792858_Chip-Seq_BT549_Human1.14807712
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.14753124
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.14494048
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14386558
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13477013
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11958797
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.11861932
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11611860
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.10851953
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10611230
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10611230
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09868983
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09079808
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08304168
102SOX9_26525672_Chip-Seq_HEART_Mouse1.07851272
103AR_19668381_ChIP-Seq_PC3_Human1.07454424
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.07112871
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06928436
106CBP_20019798_ChIP-Seq_JUKART_Human1.06928436
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06893698
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.06380748
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06080051
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.05215501
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04484874
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03985847
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.03363181
114* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02921867
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02700841
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01684935
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01546818
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00544973
119P53_22387025_ChIP-Seq_ESCs_Mouse1.00295763
120* KDM2B_26808549_Chip-Seq_REH_Human1.00132454
121TP53_18474530_ChIP-ChIP_U2OS_Human0.99658753
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99381041
123BCAT_22108803_ChIP-Seq_LS180_Human0.98963057
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97737438
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96798868
126EWS_26573619_Chip-Seq_HEK293_Human0.96667113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.31384850
2MP0004859_abnormal_synaptic_plasticity4.90743574
3MP0003635_abnormal_synaptic_transmissio3.69565757
4MP0009745_abnormal_behavioral_response3.30353545
5MP0004270_analgesia3.27713456
6MP0009046_muscle_twitch3.17768167
7MP0002063_abnormal_learning/memory/cond3.16129275
8MP0001968_abnormal_touch/_nociception3.15260784
9MP0002064_seizures3.07051609
10MP0002735_abnormal_chemical_nociception2.81026707
11MP0002572_abnormal_emotion/affect_behav2.80450312
12MP0002736_abnormal_nociception_after2.75128739
13MP0002822_catalepsy2.73802855
14MP0002734_abnormal_mechanical_nocicepti2.59031367
15MP0003283_abnormal_digestive_organ2.57079527
16MP0002272_abnormal_nervous_system2.50375075
17MP0001984_abnormal_olfaction2.41889220
18MP0006276_abnormal_autonomic_nervous2.30527829
19MP0001486_abnormal_startle_reflex2.24569808
20MP0005646_abnormal_pituitary_gland2.17045222
21MP0005423_abnormal_somatic_nervous2.13695927
22MP0002067_abnormal_sensory_capabilities2.07965770
23MP0001440_abnormal_grooming_behavior2.07086699
24MP0001501_abnormal_sleep_pattern2.04352736
25MP0003787_abnormal_imprinting2.03310933
26MP0000462_abnormal_digestive_system1.96822814
27MP0003122_maternal_imprinting1.95570689
28MP0000778_abnormal_nervous_system1.94466117
29MP0009780_abnormal_chondrocyte_physiolo1.92722791
30MP0001529_abnormal_vocalization1.92022060
31MP0001188_hyperpigmentation1.91517181
32MP0002184_abnormal_innervation1.90745640
33MP0001970_abnormal_pain_threshold1.85735494
34MP0002733_abnormal_thermal_nociception1.84811992
35MP0002557_abnormal_social/conspecific_i1.78880507
36MP0001944_abnormal_pancreas_morphology1.71255628
37MP0004924_abnormal_behavior1.68744595
38MP0005386_behavior/neurological_phenoty1.68744595
39MP0003879_abnormal_hair_cell1.64872605
40MP0005645_abnormal_hypothalamus_physiol1.64442007
41MP0006072_abnormal_retinal_apoptosis1.60389542
42MP0002876_abnormal_thyroid_physiology1.59846321
43MP0008569_lethality_at_weaning1.56822339
44MP0010234_abnormal_vibrissa_follicle1.54783060
45MP0000427_abnormal_hair_cycle1.53484899
46MP0005379_endocrine/exocrine_gland_phen1.52515381
47MP0004811_abnormal_neuron_physiology1.48515804
48MP0005499_abnormal_olfactory_system1.43872773
49MP0005394_taste/olfaction_phenotype1.43872773
50MP0002837_dystrophic_cardiac_calcinosis1.42707104
51MP0005187_abnormal_penis_morphology1.42681673
52MP0001905_abnormal_dopamine_level1.40395624
53MP0001299_abnormal_eye_distance/1.38827013
54MP0004142_abnormal_muscle_tone1.35642572
55MP0000955_abnormal_spinal_cord1.33531927
56MP0002882_abnormal_neuron_morphology1.33440090
57MP0002066_abnormal_motor_capabilities/c1.29063013
58MP0000383_abnormal_hair_follicle1.28355764
59MP0010678_abnormal_skin_adnexa1.25986421
60MP0010386_abnormal_urinary_bladder1.24955850
61MP0000516_abnormal_urinary_system1.20741433
62MP0005367_renal/urinary_system_phenotyp1.20741433
63MP0000534_abnormal_ureter_morphology1.17156178
64MP0001502_abnormal_circadian_rhythm1.13509042
65MP0002693_abnormal_pancreas_physiology1.13148537
66MP0004858_abnormal_nervous_system1.12936134
67MP0000003_abnormal_adipose_tissue1.12826379
68MP0000751_myopathy1.11908459
69MP0002909_abnormal_adrenal_gland1.11867406
70MP0002152_abnormal_brain_morphology1.08218412
71MP0008789_abnormal_olfactory_epithelium1.05361463
72MP0003329_amyloid_beta_deposits1.04568905
73MP0000538_abnormal_urinary_bladder1.04497136
74MP0000749_muscle_degeneration1.01444326
75MP0008877_abnormal_DNA_methylation1.00319994
76MP0000631_abnormal_neuroendocrine_gland0.98824688
77MP0001963_abnormal_hearing_physiology0.98137273
78MP0005171_absent_coat_pigmentation0.94790671
79MP0003633_abnormal_nervous_system0.94492276
80MP0002234_abnormal_pharynx_morphology0.93854622
81MP0002127_abnormal_cardiovascular_syste0.93808184
82MP0002069_abnormal_eating/drinking_beha0.93729344
83MP0004036_abnormal_muscle_relaxation0.92752275
84MP0002653_abnormal_ependyma_morphology0.92507074
85MP0004085_abnormal_heartbeat0.91661230
86MP0005551_abnormal_eye_electrophysiolog0.91480270
87MP0001986_abnormal_taste_sensitivity0.90467383
88MP0004145_abnormal_muscle_electrophysio0.90306514
89MP0003121_genomic_imprinting0.88875163
90MP0002078_abnormal_glucose_homeostasis0.88088696
91MP0000013_abnormal_adipose_tissue0.87358314
92MP0004084_abnormal_cardiac_muscle0.86404429
93MP0010352_gastrointestinal_tract_polyps0.86288424
94MP0005620_abnormal_muscle_contractility0.86141401
95MP0005220_abnormal_exocrine_pancreas0.86115229
96MP0001756_abnormal_urination0.85758415
97MP0002752_abnormal_somatic_nervous0.85118231
98MP0003631_nervous_system_phenotype0.84539918
99MP0005503_abnormal_tendon_morphology0.84524987
100MP0004742_abnormal_vestibular_system0.83422141
101MP0002108_abnormal_muscle_morphology0.82837439
102MP0008438_abnormal_cutaneous_collagen0.82405779
103MP0000613_abnormal_salivary_gland0.82072585
104MP0002229_neurodegeneration0.81650514
105MP0002896_abnormal_bone_mineralization0.81274641
106MP0001958_emphysema0.80474543
107MP0002295_abnormal_pulmonary_circulatio0.80307756
108MP0004215_abnormal_myocardial_fiber0.79059838
109MP0005275_abnormal_skin_tensile0.78991507
110MP0002751_abnormal_autonomic_nervous0.77864097
111MP0000026_abnormal_inner_ear0.76602879
112MP0002638_abnormal_pupillary_reflex0.75519842
113MP0005257_abnormal_intraocular_pressure0.75262519
114MP0004484_altered_response_of0.75126718
115MP0005248_abnormal_Harderian_gland0.74882188
116MP0008872_abnormal_physiological_respon0.74862458
117MP0002254_reproductive_system_inflammat0.74125180
118MP0004134_abnormal_chest_morphology0.73780053
119MP0005253_abnormal_eye_physiology0.73766129
120MP0003942_abnormal_urinary_system0.73648686
121MP0003698_abnormal_male_reproductive0.73488255
122MP0001177_atelectasis0.71744774
123MP0004885_abnormal_endolymph0.71533081
124MP0001765_abnormal_ion_homeostasis0.71210820
125MP0000639_abnormal_adrenal_gland0.70748122
126MP0003646_muscle_fatigue0.70497497
127MP0008874_decreased_physiological_sensi0.70267591
128MP0005535_abnormal_body_temperature0.70036881
129MP0002168_other_aberrant_phenotype0.69797126
130MP0003195_calcinosis0.69359702
131MP0000566_synostosis0.67684711
132MP0002163_abnormal_gland_morphology0.67258542
133MP0001664_abnormal_digestion0.66911042
134MP0001485_abnormal_pinna_reflex0.64459445
135MP0001943_abnormal_respiration0.63970088
136MP0002160_abnormal_reproductive_system0.62192114
137MP0006292_abnormal_olfactory_placode0.61145660
138MP0005410_abnormal_fertilization0.61098440
139MP0003183_abnormal_peptide_metabolism0.59680690
140MP0003861_abnormal_nervous_system0.59559247
141MP0005409_darkened_coat_color0.59325596
142MP0003137_abnormal_impulse_conducting0.59236847
143MP0003634_abnormal_glial_cell0.55434178
144MP0002082_postnatal_lethality0.54897704
145MP0010770_preweaning_lethality0.54897704
146MP0004043_abnormal_pH_regulation0.54113232
147MP0002102_abnormal_ear_morphology0.52268507
148MP0010769_abnormal_survival0.51064099

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.63151637
2Atonic seizures (HP:0010819)5.26411296
3Epileptic encephalopathy (HP:0200134)5.21176647
4Hyperventilation (HP:0002883)5.17457899
5Febrile seizures (HP:0002373)4.97633007
6Focal seizures (HP:0007359)4.94589806
7Myokymia (HP:0002411)4.53749025
8Absence seizures (HP:0002121)3.94729765
9Hypoglycemic seizures (HP:0002173)3.76104332
10Dialeptic seizures (HP:0011146)3.70082280
11Gait imbalance (HP:0002141)3.60304107
12Visual hallucinations (HP:0002367)3.60073782
13Progressive cerebellar ataxia (HP:0002073)3.58266016
14Broad-based gait (HP:0002136)3.51496849
15Abnormal hair whorl (HP:0010721)3.50723369
16Volvulus (HP:0002580)3.44367314
17Medial flaring of the eyebrow (HP:0010747)3.37904363
18Congenital primary aphakia (HP:0007707)3.33869493
19Generalized tonic-clonic seizures (HP:0002069)3.30728394
20Widely spaced teeth (HP:0000687)3.14716218
21Enlarged penis (HP:0000040)3.12129266
22Nephrogenic diabetes insipidus (HP:0009806)3.12052735
23Gaze-evoked nystagmus (HP:0000640)3.07717433
24Amblyopia (HP:0000646)3.02180114
25Impaired vibration sensation in the lower limbs (HP:0002166)2.89056621
26Abnormal respiratory motile cilium physiology (HP:0012261)2.86516620
27Abnormal ciliary motility (HP:0012262)2.85276266
28Hyperinsulinemic hypoglycemia (HP:0000825)2.84247650
29Absent/shortened dynein arms (HP:0200106)2.83455210
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.83455210
31Buphthalmos (HP:0000557)2.82943560
32Protruding tongue (HP:0010808)2.82689161
33Drooling (HP:0002307)2.82421548
34Excessive salivation (HP:0003781)2.82421548
35Pheochromocytoma (HP:0002666)2.82163506
36Hyperglycemia (HP:0003074)2.80796602
37Truncal ataxia (HP:0002078)2.78385990
38Abnormal respiratory epithelium morphology (HP:0012253)2.73246005
39Abnormal respiratory motile cilium morphology (HP:0005938)2.73246005
40Epileptiform EEG discharges (HP:0011182)2.71988321
41Abnormal eating behavior (HP:0100738)2.66890594
42Absent speech (HP:0001344)2.66208318
43Fetal akinesia sequence (HP:0001989)2.65058674
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63680445
45Neuroendocrine neoplasm (HP:0100634)2.62325341
46Polyphagia (HP:0002591)2.61561286
47Muscle hypertrophy of the lower extremities (HP:0008968)2.59526900
48Genital tract atresia (HP:0001827)2.56571597
49Hypoglycemic coma (HP:0001325)2.53756905
50Vaginal atresia (HP:0000148)2.52791494
51Inability to walk (HP:0002540)2.51466206
52Poor coordination (HP:0002370)2.50755337
53Acute necrotizing encephalopathy (HP:0006965)2.50659190
54Hypoplastic ischia (HP:0003175)2.48416516
55Ketoacidosis (HP:0001993)2.47167870
56Specific learning disability (HP:0001328)2.44936620
57Failure to thrive in infancy (HP:0001531)2.43398810
58Poor suck (HP:0002033)2.43039388
59Abnormal mitochondria in muscle tissue (HP:0008316)2.42614038
60EEG with generalized epileptiform discharges (HP:0011198)2.42395494
61Progressive inability to walk (HP:0002505)2.41485277
62Poor eye contact (HP:0000817)2.38565005
63Anxiety (HP:0000739)2.36046790
64Rhinitis (HP:0012384)2.35205948
65Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.34546597
66Short 1st metacarpal (HP:0010034)2.34546597
67Progressive macrocephaly (HP:0004481)2.34057263
68Limb dystonia (HP:0002451)2.32917711
69Calf muscle hypertrophy (HP:0008981)2.31766252
70Blue irides (HP:0000635)2.30959575
71Abnormality of the labia minora (HP:0012880)2.28462390
72Symptomatic seizures (HP:0011145)2.26875869
73Bundle branch block (HP:0011710)2.26234507
74Dysdiadochokinesis (HP:0002075)2.25916009
75Hypsarrhythmia (HP:0002521)2.25212904
76Hyperthyroidism (HP:0000836)2.24974667
77Hamartoma of the eye (HP:0010568)2.23810243
78Intestinal atresia (HP:0011100)2.23636256
79Abnormality of the lower motor neuron (HP:0002366)2.22465794
80Urinary bladder sphincter dysfunction (HP:0002839)2.22387603
81Depression (HP:0000716)2.21838778
82Abnormality of the ischium (HP:0003174)2.21702335
83Truncal obesity (HP:0001956)2.21490777
84Insulin-resistant diabetes mellitus (HP:0000831)2.21440526
85Papillary thyroid carcinoma (HP:0002895)2.19470011
86Abnormal social behavior (HP:0012433)2.17653217
87Impaired social interactions (HP:0000735)2.17653217
88Ankle clonus (HP:0011448)2.09823151
89Dysmetric saccades (HP:0000641)2.05027725
90Abnormality of the 1st metacarpal (HP:0010009)2.02711359
91Action tremor (HP:0002345)2.02709892
92Narrow nasal bridge (HP:0000446)2.02675080
93Scanning speech (HP:0002168)2.02178447
94Macroorchidism (HP:0000053)2.01494762
95Thyroid carcinoma (HP:0002890)2.00737381
96Hemiparesis (HP:0001269)1.99547033
97Abnormality of calcium-phosphate metabolism (HP:0100530)1.99324721
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98845818
99Aplasia/Hypoplasia of the lens (HP:0008063)1.98263346
100Impaired vibratory sensation (HP:0002495)1.98193554
101Hypothermia (HP:0002045)1.98072376
102Impaired smooth pursuit (HP:0007772)1.97345464
103Oligomenorrhea (HP:0000876)1.95844883
104Dysmetria (HP:0001310)1.95024669
105Esotropia (HP:0000565)1.94882450
106Abnormality of salivation (HP:0100755)1.92380205
107Abnormality of the metopic suture (HP:0005556)1.91483831
108Testicular neoplasm (HP:0010788)1.91237791
109Retinal dysplasia (HP:0007973)1.91174318
110Hypoventilation (HP:0002791)1.91087648
111Pancreatic fibrosis (HP:0100732)1.90560893
112Congenital glaucoma (HP:0001087)1.90379060
113Fair hair (HP:0002286)1.89523884
114Sensory axonal neuropathy (HP:0003390)1.89086363
115Thyroiditis (HP:0100646)1.87879562
116Bradycardia (HP:0001662)1.87765949
117Neoplasm of the adrenal cortex (HP:0100641)1.87658931
118Supranuclear gaze palsy (HP:0000605)1.87057952
119Genetic anticipation (HP:0003743)1.86438742
120Downturned corners of mouth (HP:0002714)1.85287185
121Abnormal drinking behavior (HP:0030082)1.85227577
122Polydipsia (HP:0001959)1.85227577
123Insidious onset (HP:0003587)1.84918677
124Termporal pattern (HP:0011008)1.84918677
125Abnormality of the calf musculature (HP:0001430)1.84860235
126Syncope (HP:0001279)1.84730126
127Menstrual irregularities (HP:0000858)1.83454041
128Asymmetry of the thorax (HP:0001555)1.82311970
129Prominent metopic ridge (HP:0005487)1.82103199
130Generalized hypopigmentation of hair (HP:0011358)1.81733919
131Acute encephalopathy (HP:0006846)1.80819494
132Akinesia (HP:0002304)1.80815210
133Spastic gait (HP:0002064)1.80000230
134Sex reversal (HP:0012245)1.79904087
135Abnormal sex determination (HP:0012244)1.79904087
136Diplopia (HP:0000651)1.79780138
137Abnormality of binocular vision (HP:0011514)1.79780138
138Hyporeflexia of lower limbs (HP:0002600)1.77853183
139Atrioventricular canal defect (HP:0006695)1.77541223
140Sleep apnea (HP:0010535)1.77069005
141Striae distensae (HP:0001065)1.76296344
142Abnormality of the corticospinal tract (HP:0002492)1.75965860
143Bell-shaped thorax (HP:0001591)1.75815263
144Spinal rigidity (HP:0003306)1.75339873
145Urinary urgency (HP:0000012)1.75255144
146Bradykinesia (HP:0002067)1.74985406
147Optic disc pallor (HP:0000543)1.74670168
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74005590
149Mitochondrial inheritance (HP:0001427)1.73980921
150Open mouth (HP:0000194)1.73148918
151Lower limb muscle weakness (HP:0007340)1.72982683
152Type 1 muscle fiber predominance (HP:0003803)1.72026653
153Lymphangioma (HP:0100764)1.71199115
154Double outlet right ventricle (HP:0001719)1.71006348
155Congenital malformation of the right heart (HP:0011723)1.71006348
156Popliteal pterygium (HP:0009756)1.69904224
157Absent frontal sinuses (HP:0002688)1.69813279
158Round ear (HP:0100830)1.68969304
159Short hallux (HP:0010109)1.68433570
160Microglossia (HP:0000171)1.67235393
161Abnormality of the astrocytes (HP:0100707)1.66896065
162Astrocytoma (HP:0009592)1.66896065
163Hyperkalemia (HP:0002153)1.65885925
164Abnormality of the frontal sinuses (HP:0002687)1.63140475
165Aqueductal stenosis (HP:0002410)1.62540281
166Intellectual disability, progressive (HP:0006887)1.61462825
167Complete atrioventricular canal defect (HP:0001674)1.60879840
168Urethral obstruction (HP:0000796)1.60796899
169Relative macrocephaly (HP:0004482)1.60159939
170Large for gestational age (HP:0001520)1.59263976
171Hyperphosphatemia (HP:0002905)1.59127234
172Conjunctival hamartoma (HP:0100780)1.57346791
173Asymmetric septal hypertrophy (HP:0001670)1.56391388
174Limited hip movement (HP:0008800)1.56082276
175Tented upper lip vermilion (HP:0010804)1.55856849
176Exostoses (HP:0100777)1.55785426
177Abnormality of molar morphology (HP:0011070)1.54930659
178Abnormality of molar (HP:0011077)1.54930659
179Abnormal pancreas size (HP:0012094)1.52960532
180Aplasia/Hypoplasia of the hallux (HP:0008362)1.50475272
181Shawl scrotum (HP:0000049)1.50165022
182Abnormality of macular pigmentation (HP:0008002)1.49103947
183Neoplasm of the thyroid gland (HP:0100031)1.48742962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86045582
2CASK5.61715066
3NTRK33.82093118
4MAP2K73.49515338
5MAP3K43.14007847
6EPHA43.12586776
7MAP3K122.93540735
8AKT32.50234360
9FGFR22.48997457
10MARK12.47490740
11MINK12.32345587
12PLK22.31087163
13DAPK22.29293342
14PRPF4B2.23487930
15TRPM72.09458632
16MAP3K92.01912518
17MAP4K22.00466692
18CDK191.95151711
19DAPK11.93394174
20MAPK131.89760205
21MAP2K41.86185011
22SIK31.84276776
23NTRK21.79901297
24PNCK1.75621393
25SGK21.57289439
26KSR11.53344803
27GRK11.51757005
28CCNB11.50129018
29SCYL21.46971491
30STK38L1.46503460
31MST41.46331435
32INSRR1.42624734
33SGK4941.41651765
34SGK2231.41651765
35CAMK1G1.40708164
36GRK51.40571919
37TAF11.38984911
38PRKCG1.28891435
39ARAF1.26697249
40TSSK61.26006612
41BMPR21.24856160
42RIPK41.23884263
43OXSR11.19043179
44CDK51.17110748
45PTK21.15526953
46TNIK1.13441564
47ROCK11.11711994
48OBSCN1.10777846
49CAMK2A1.06454126
50PDK31.05411956
51PDK41.05411956
52FGFR31.01952039
53CAMKK21.01474000
54BRAF1.01358619
55NME11.01018716
56BCR0.99554647
57PAK60.99300976
58PIK3CA0.96673180
59SGK30.94419966
60PTK2B0.94337598
61CAMK2B0.94146329
62STK30.89710430
63PRKD30.86847455
64ERBB30.86478656
65CAMKK10.85491810
66LATS10.79630671
67MET0.77397991
68WNK30.77226365
69PRKCE0.77123616
70UHMK10.75702347
71DDR20.75336722
72PHKG10.74268784
73PHKG20.74268784
74YES10.73199196
75NTRK10.72638267
76NUAK10.72240740
77PRKG20.72004780
78PASK0.69845096
79CDK180.69717537
80HIPK20.68900270
81FES0.68842045
82NEK60.67719915
83SIK20.67406969
84DYRK1A0.67296094
85RPS6KB20.66611279
86PRKAA10.66228435
87PRKCI0.63961497
88DMPK0.62756868
89MYLK0.62568068
90SGK10.62026542
91KSR20.61967977
92MAPKAPK30.61837147
93MUSK0.61660370
94ADRBK20.61601521
95CSNK1G10.61081994
96CDK140.60696990
97EIF2AK30.59997514
98CDK30.59497089
99CDK150.57199319
100ILK0.57164043
101STK240.56965194
102PRKD20.56120181
103BRD40.55360942
104CSNK1G20.54561253
105CSNK1D0.53961753
106FER0.53647435
107CAMK2D0.51957240
108TTN0.51511594
109LIMK10.51491253
110PDGFRA0.50499597
111CAMK10.50071553
112ADRBK10.48989478
113MKNK20.48424559
114PDK20.48182701
115PAK30.48028350
116RPS6KA20.47912932
117CDK11A0.46942737
118ACVR1B0.46747747
119PRKCH0.46537353
120CAMK2G0.46013977
121CDK80.45383076
122CDC42BPA0.45139125
123PLK30.44878490
124TNK20.43944210
125BMPR1B0.42903648
126GRK70.41787763
127STK110.41689498
128PRKG10.41661595
129MAP3K20.41495066
130PRKAA20.41233003
131DAPK30.39570956
132BRSK20.39501490
133PINK10.38413970
134DYRK20.37565344
135STK380.37360126
136ROCK20.37194200
137CSNK1E0.36937787
138MAP2K10.36743264
139PRKACA0.36217733
140PRKCZ0.36014634
141CAMK40.33268644
142RPS6KB10.32828939
143FGR0.30967216
144MAP3K60.30818475
145RPS6KA30.30233091
146RAF10.27662932
147MAPK120.27501133

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.18396465
2Synaptic vesicle cycle_Homo sapiens_hsa047213.89280575
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.59378875
4Vitamin B6 metabolism_Homo sapiens_hsa007503.43569198
5Olfactory transduction_Homo sapiens_hsa047403.14063138
6Collecting duct acid secretion_Homo sapiens_hsa049662.96022063
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87721893
8Circadian entrainment_Homo sapiens_hsa047132.66418370
9GABAergic synapse_Homo sapiens_hsa047272.65104324
10Morphine addiction_Homo sapiens_hsa050322.58722239
11Amphetamine addiction_Homo sapiens_hsa050312.50466732
12Long-term potentiation_Homo sapiens_hsa047202.50061790
13Glutamatergic synapse_Homo sapiens_hsa047242.42558889
14Taste transduction_Homo sapiens_hsa047422.24140204
15Dopaminergic synapse_Homo sapiens_hsa047282.21284872
16Insulin secretion_Homo sapiens_hsa049111.94101004
17Vibrio cholerae infection_Homo sapiens_hsa051101.87258827
18Serotonergic synapse_Homo sapiens_hsa047261.87160387
19Oxidative phosphorylation_Homo sapiens_hsa001901.86204363
20Salivary secretion_Homo sapiens_hsa049701.82960802
21Renin secretion_Homo sapiens_hsa049241.64926385
22Cholinergic synapse_Homo sapiens_hsa047251.62888358
23Selenocompound metabolism_Homo sapiens_hsa004501.62466994
24Long-term depression_Homo sapiens_hsa047301.61407754
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56268493
26Calcium signaling pathway_Homo sapiens_hsa040201.55473126
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55457443
28Gastric acid secretion_Homo sapiens_hsa049711.54522801
29Cocaine addiction_Homo sapiens_hsa050301.51022352
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49539602
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44884145
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43872013
33Oxytocin signaling pathway_Homo sapiens_hsa049211.42388644
34Phototransduction_Homo sapiens_hsa047441.41644372
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35412080
36Alzheimers disease_Homo sapiens_hsa050101.31139097
37Parkinsons disease_Homo sapiens_hsa050121.30041033
38Non-homologous end-joining_Homo sapiens_hsa034501.27952840
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27086876
40Cardiac muscle contraction_Homo sapiens_hsa042601.25379143
41mTOR signaling pathway_Homo sapiens_hsa041501.21408858
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16443209
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14162803
44Gap junction_Homo sapiens_hsa045401.10333584
45Axon guidance_Homo sapiens_hsa043601.08521423
46GnRH signaling pathway_Homo sapiens_hsa049121.08406190
47cAMP signaling pathway_Homo sapiens_hsa040241.07962505
48Protein export_Homo sapiens_hsa030601.07042487
49TGF-beta signaling pathway_Homo sapiens_hsa043501.05202752
50Huntingtons disease_Homo sapiens_hsa050161.04912761
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03461221
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02481812
53Propanoate metabolism_Homo sapiens_hsa006401.01058508
54Sulfur metabolism_Homo sapiens_hsa009201.00143949
55Tight junction_Homo sapiens_hsa045300.98936835
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94537351
57ErbB signaling pathway_Homo sapiens_hsa040120.94044291
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91787610
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90190614
60Estrogen signaling pathway_Homo sapiens_hsa049150.87777135
61Melanogenesis_Homo sapiens_hsa049160.86746955
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.80992621
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77960007
64Glioma_Homo sapiens_hsa052140.76612438
65Hedgehog signaling pathway_Homo sapiens_hsa043400.76138418
66Rheumatoid arthritis_Homo sapiens_hsa053230.75033720
67beta-Alanine metabolism_Homo sapiens_hsa004100.74913688
68Sphingolipid metabolism_Homo sapiens_hsa006000.74880343
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71678206
70Focal adhesion_Homo sapiens_hsa045100.70764860
71Type II diabetes mellitus_Homo sapiens_hsa049300.70200350
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69404178
73Hippo signaling pathway_Homo sapiens_hsa043900.67414835
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67208777
75Oocyte meiosis_Homo sapiens_hsa041140.66843342
76Glucagon signaling pathway_Homo sapiens_hsa049220.65130113
77Protein digestion and absorption_Homo sapiens_hsa049740.64422357
78Insulin resistance_Homo sapiens_hsa049310.63644631
79AMPK signaling pathway_Homo sapiens_hsa041520.63610880
80MAPK signaling pathway_Homo sapiens_hsa040100.62198597
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61929628
82Dilated cardiomyopathy_Homo sapiens_hsa054140.60904987
83Type I diabetes mellitus_Homo sapiens_hsa049400.60448070
84Folate biosynthesis_Homo sapiens_hsa007900.58546362
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58330033
86ABC transporters_Homo sapiens_hsa020100.58239168
87Ether lipid metabolism_Homo sapiens_hsa005650.57609098
88Alcoholism_Homo sapiens_hsa050340.56815345
89Ras signaling pathway_Homo sapiens_hsa040140.56212041
90Phagosome_Homo sapiens_hsa041450.54239378
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.54010607
92ECM-receptor interaction_Homo sapiens_hsa045120.53925511
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53324146
94Thyroid hormone synthesis_Homo sapiens_hsa049180.53223027
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50700556
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50458601
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50045802
98Pyruvate metabolism_Homo sapiens_hsa006200.49368897
99Pancreatic secretion_Homo sapiens_hsa049720.49034377
100Circadian rhythm_Homo sapiens_hsa047100.43291473
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42638731
102Wnt signaling pathway_Homo sapiens_hsa043100.38967131
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36284455
104Rap1 signaling pathway_Homo sapiens_hsa040150.35960566
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34714121
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34156861
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34110878
108Dorso-ventral axis formation_Homo sapiens_hsa043200.33959312
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.33652500
110Endometrial cancer_Homo sapiens_hsa052130.33601850
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.33046724
112Choline metabolism in cancer_Homo sapiens_hsa052310.32967714
113Inositol phosphate metabolism_Homo sapiens_hsa005620.32466839
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32195230
115Melanoma_Homo sapiens_hsa052180.31873248
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29621736
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29353273
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28493386
119Insulin signaling pathway_Homo sapiens_hsa049100.28237287
120Butanoate metabolism_Homo sapiens_hsa006500.28049353
121Regulation of autophagy_Homo sapiens_hsa041400.27912030
122Ovarian steroidogenesis_Homo sapiens_hsa049130.27595859
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24159729
124Prion diseases_Homo sapiens_hsa050200.23861755
125Colorectal cancer_Homo sapiens_hsa052100.20281771
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19167887

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