TSPYL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)4.96706403
2regulation of glucokinase activity (GO:0033131)4.79843341
3regulation of hexokinase activity (GO:1903299)4.79843341
4neuron cell-cell adhesion (GO:0007158)4.68595668
5regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.67042243
6synaptic vesicle exocytosis (GO:0016079)4.65296054
7regulation of synaptic vesicle exocytosis (GO:2000300)4.56975946
8vocalization behavior (GO:0071625)4.40725945
9lactate metabolic process (GO:0006089)4.40048262
10presynaptic membrane assembly (GO:0097105)4.39202545
11neurotransmitter-gated ion channel clustering (GO:0072578)4.38471343
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28592974
13glutamate secretion (GO:0014047)4.23517902
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.20405683
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17976921
16neuronal action potential propagation (GO:0019227)4.15264497
17protein localization to synapse (GO:0035418)4.13079911
18regulation of synaptic vesicle transport (GO:1902803)4.12455621
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.04787363
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.03557214
21synaptic vesicle maturation (GO:0016188)4.02783170
22regulation of glutamate receptor signaling pathway (GO:1900449)4.00981039
23presynaptic membrane organization (GO:0097090)4.00362226
24cellular ketone body metabolic process (GO:0046950)3.88856017
25positive regulation of glycolytic process (GO:0045821)3.79217619
26inositol phosphate catabolic process (GO:0071545)3.78778973
27water-soluble vitamin biosynthetic process (GO:0042364)3.76375791
28postsynaptic membrane organization (GO:0001941)3.74382707
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70607720
30respiratory chain complex IV assembly (GO:0008535)3.69744094
31negative regulation of dendrite development (GO:2000171)3.67543221
32positive regulation of protein autophosphorylation (GO:0031954)3.60367563
33ketone body metabolic process (GO:1902224)3.58533040
34neuron-neuron synaptic transmission (GO:0007270)3.56235478
35neurotransmitter secretion (GO:0007269)3.53336084
36regulation of type B pancreatic cell apoptotic process (GO:2000674)3.49353060
37insulin secretion (GO:0030073)3.41943015
38long-term synaptic potentiation (GO:0060291)3.40933569
39dendritic spine morphogenesis (GO:0060997)3.39414193
40transferrin transport (GO:0033572)3.37276701
41synaptic transmission, glutamatergic (GO:0035249)3.37035646
42polyol catabolic process (GO:0046174)3.36807511
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.35369505
44regulation of neuronal synaptic plasticity (GO:0048168)3.30228260
45glutamate receptor signaling pathway (GO:0007215)3.28215842
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.25814820
47negative regulation of protein oligomerization (GO:0032460)3.21772289
48cytochrome complex assembly (GO:0017004)3.19334829
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18757991
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.14931345
51endocrine pancreas development (GO:0031018)3.14693335
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13826996
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13382268
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12547168
55trivalent inorganic cation transport (GO:0072512)3.12422228
56ferric iron transport (GO:0015682)3.12422228
57locomotory exploration behavior (GO:0035641)3.12368013
58synaptic vesicle endocytosis (GO:0048488)3.10602499
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09889654
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.06648667
61serotonin receptor signaling pathway (GO:0007210)3.05262166
62regulation of glutamate secretion (GO:0014048)3.04759582
63regulation of synaptic transmission, GABAergic (GO:0032228)3.03179250
64positive regulation of glycoprotein biosynthetic process (GO:0010560)3.02121999
65striatum development (GO:0021756)3.01085420
66regulation of neurotransmitter secretion (GO:0046928)2.99969670
67regulation of postsynaptic membrane potential (GO:0060078)2.98626763
68signal peptide processing (GO:0006465)2.98471428
69dopamine transport (GO:0015872)2.96883413
70startle response (GO:0001964)2.95773218
71positive regulation of membrane potential (GO:0045838)2.94086818
72zinc ion transport (GO:0006829)2.93761189
73regulation of synaptic plasticity (GO:0048167)2.93754939
74exploration behavior (GO:0035640)2.93164405
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92882586
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92756817
77chemosensory behavior (GO:0007635)2.91753344
78response to pheromone (GO:0019236)2.91680538
79keratinocyte development (GO:0003334)2.91658154
80regulation of protein glycosylation (GO:0060049)2.91375958
81energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90961051
82ATP hydrolysis coupled proton transport (GO:0015991)2.90961051
83regulation of synapse structural plasticity (GO:0051823)2.90785639
84regulation of vesicle fusion (GO:0031338)2.90501226
85negative regulation of hormone biosynthetic process (GO:0032353)2.88383301
86innervation (GO:0060384)2.88092178
87positive regulation of actin filament depolymerization (GO:0030836)2.85570854
88regulation of neurotransmitter uptake (GO:0051580)2.84805912
89neuron recognition (GO:0008038)2.83977015
90membrane depolarization during action potential (GO:0086010)2.83700457
91branched-chain amino acid catabolic process (GO:0009083)2.83409638
92neurotransmitter transport (GO:0006836)2.82745988
93positive regulation of neurotransmitter transport (GO:0051590)2.82577254
94nitric oxide mediated signal transduction (GO:0007263)2.82399365
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80894392
96regulation of neurotransmitter transport (GO:0051588)2.80112513
97female mating behavior (GO:0060180)2.79545798
98cerebellar granule cell differentiation (GO:0021707)2.79368624
99negative regulation of neurological system process (GO:0031645)2.79059079
100phagosome maturation (GO:0090382)2.78993388
101synapse assembly (GO:0007416)2.78542217
102neuronal action potential (GO:0019228)2.76763569
103phosphorylated carbohydrate dephosphorylation (GO:0046838)2.76145191
104inositol phosphate dephosphorylation (GO:0046855)2.76145191
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75565849
106kidney morphogenesis (GO:0060993)2.75449624
107urinary tract smooth muscle contraction (GO:0014848)2.74347354
108membrane depolarization (GO:0051899)2.73200789
109regulation of female receptivity (GO:0045924)2.73196589
110positive regulation of synapse assembly (GO:0051965)2.73175498
111prostate gland growth (GO:0060736)2.72909136
112dendrite development (GO:0016358)2.72272280
113positive regulation of synaptic transmission (GO:0050806)2.72071650
114mechanosensory behavior (GO:0007638)2.71802991
115response to histamine (GO:0034776)2.71468199
116regulation of voltage-gated calcium channel activity (GO:1901385)2.71446291
117transmission of nerve impulse (GO:0019226)2.71093773
118learning (GO:0007612)2.70396704
119calcium ion-dependent exocytosis (GO:0017156)2.70013701
120synaptic transmission (GO:0007268)2.69757165
121positive regulation of neurotransmitter secretion (GO:0001956)2.69349731
122fucose catabolic process (GO:0019317)2.68670949
123L-fucose metabolic process (GO:0042354)2.68670949
124L-fucose catabolic process (GO:0042355)2.68670949
125cerebellar Purkinje cell differentiation (GO:0021702)2.68573736
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68373986
127negative regulation of neurotransmitter transport (GO:0051589)2.67666751
128positive regulation of insulin secretion (GO:0032024)2.66607092
129platelet dense granule organization (GO:0060155)2.66211723
130proline transport (GO:0015824)2.66090470
131protein localization to cilium (GO:0061512)2.66048773
132detection of calcium ion (GO:0005513)2.65835367
133positive regulation of peptide hormone secretion (GO:0090277)2.65592446
134positive regulation of meiosis (GO:0045836)2.65069728
135regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64245648
136establishment of synaptic vesicle localization (GO:0097480)2.63562809
137synaptic vesicle transport (GO:0048489)2.63562809
138adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63231446
139positive regulation of mitochondrial fission (GO:0090141)2.62254200
140regulation of synaptic transmission (GO:0050804)2.61606431
141cell migration in hindbrain (GO:0021535)2.60823242
142positive regulation of peptide secretion (GO:0002793)2.57595159
143positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.57409246
144glycerophospholipid catabolic process (GO:0046475)2.56920150
145peptidyl-cysteine modification (GO:0018198)2.53906497
146parental behavior (GO:0060746)2.52636074
147regulation of insulin secretion (GO:0050796)2.52323039
148negative regulation of membrane potential (GO:0045837)2.51542250
149positive regulation of glycoprotein metabolic process (GO:1903020)2.51517232
150axoneme assembly (GO:0035082)2.50916021
151negative regulation of acute inflammatory response (GO:0002674)2.48697769
152regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.48579287
153regulation of protein autophosphorylation (GO:0031952)2.47599026
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46909241
155protein K11-linked deubiquitination (GO:0035871)2.46443737
156righting reflex (GO:0060013)2.45235308
157positive regulation of meiotic cell cycle (GO:0051446)2.44862155
158brain morphogenesis (GO:0048854)2.42313582
159positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42011542
160regulation of Rac protein signal transduction (GO:0035020)2.41684425
161regulation of calcium ion-dependent exocytosis (GO:0017158)2.40322086
162aggressive behavior (GO:0002118)2.39577900
163positive regulation of macroautophagy (GO:0016239)2.39561053
164protein K6-linked ubiquitination (GO:0085020)2.38940208
165catecholamine transport (GO:0051937)2.36873140
166regulation of peptide hormone secretion (GO:0090276)2.34945563
167negative regulation of hormone metabolic process (GO:0032351)2.34361167
168prenylation (GO:0097354)2.32651089
169protein prenylation (GO:0018342)2.32651089
170protein complex biogenesis (GO:0070271)2.31634175
171adaptation of signaling pathway (GO:0023058)2.31045894
172response to amphetamine (GO:0001975)2.30288738
173regulation of peptide secretion (GO:0002791)2.30175601
174atrial cardiac muscle cell action potential (GO:0086014)2.29219404
175zinc ion homeostasis (GO:0055069)2.29006008
176fatty acid homeostasis (GO:0055089)2.28107618
177dentate gyrus development (GO:0021542)2.26970572
178retinal cone cell development (GO:0046549)2.25748575
179alanine transport (GO:0032328)2.24677627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.51669922
2EZH2_22144423_ChIP-Seq_EOC_Human4.43792425
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.00609860
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87263854
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86853003
6TAF15_26573619_Chip-Seq_HEK293_Human2.79797788
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76555663
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59639546
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.57951809
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41147575
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38674676
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29246753
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23531857
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22353235
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22353235
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21018235
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.20112511
18REST_21632747_ChIP-Seq_MESCs_Mouse2.19455202
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13887230
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12740837
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09769532
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.08104954
23P300_19829295_ChIP-Seq_ESCs_Human2.06125662
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05829005
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05232157
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02347784
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02184823
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.96618786
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.92973050
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90667715
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.85277707
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84991508
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84538622
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84490451
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81185996
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79669354
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.76613858
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.76471154
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.72495181
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70942203
41IGF1R_20145208_ChIP-Seq_DFB_Human1.70455596
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69788909
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67188372
44RNF2_27304074_Chip-Seq_NSC_Mouse1.66912520
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65994583
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64212716
47AR_21572438_ChIP-Seq_LNCaP_Human1.61707621
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60747111
49VDR_22108803_ChIP-Seq_LS180_Human1.59882329
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58584551
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55053532
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53438454
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.52860853
54AR_25329375_ChIP-Seq_VCAP_Human1.52520299
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52282789
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49769394
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48595000
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.47952127
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47172758
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.46401651
61DROSHA_22980978_ChIP-Seq_HELA_Human1.45999368
62FUS_26573619_Chip-Seq_HEK293_Human1.44125527
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43883586
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.42981239
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.41906880
66* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40046419
67STAT3_23295773_ChIP-Seq_U87_Human1.37470040
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35366903
69NANOG_19829295_ChIP-Seq_ESCs_Human1.34889622
70SOX2_19829295_ChIP-Seq_ESCs_Human1.34889622
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34363220
72ER_23166858_ChIP-Seq_MCF-7_Human1.32044003
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29570366
74CBP_20019798_ChIP-Seq_JUKART_Human1.29570366
75TCF4_22108803_ChIP-Seq_LS180_Human1.28964334
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.28257677
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27930430
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.27910528
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27667195
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27534174
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26247003
82TP53_22573176_ChIP-Seq_HFKS_Human1.25532764
83* CRX_20693478_ChIP-Seq_RETINA_Mouse1.25529661
84HTT_18923047_ChIP-ChIP_STHdh_Human1.25367085
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24971630
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.24342860
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.24173397
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.23873235
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23486991
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21746093
91JUN_21703547_ChIP-Seq_K562_Human1.21096752
92CDX2_22108803_ChIP-Seq_LS180_Human1.21006889
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20620070
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20522575
95AHR_22903824_ChIP-Seq_MCF-7_Human1.20344522
96TCF4_23295773_ChIP-Seq_U87_Human1.20127373
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18715372
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17662650
99RUNX2_22187159_ChIP-Seq_PCA_Human1.17449336
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17015668
101* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16759973
102* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15937810
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15317861
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15285308
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15115373
106P300_18555785_Chip-Seq_ESCs_Mouse1.14693002
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.14287518
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.12525866
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12516592
110TP53_18474530_ChIP-ChIP_U2OS_Human1.12270312
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.11908768
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10746858
113EST1_17652178_ChIP-ChIP_JURKAT_Human1.09515177
114P53_22387025_ChIP-Seq_ESCs_Mouse1.09027428
115KDM2B_26808549_Chip-Seq_REH_Human1.08871594
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.08014679
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07994167
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.07994167
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07267399
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06897521
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06827257
122* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06747119
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06609601
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05197378
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04843428
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04636541
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.03525884
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03085127
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03000587
130* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02976993
131* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01483515
132ELK1_19687146_ChIP-ChIP_HELA_Human1.01365085
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99691268
134EWS_26573619_Chip-Seq_HEK293_Human0.99399080
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99229771
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99229771
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99089353
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97783638
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97281027
140ZNF274_21170338_ChIP-Seq_K562_Hela0.96952907
141AR_19668381_ChIP-Seq_PC3_Human0.96625392
142BCAT_22108803_ChIP-Seq_LS180_Human0.95537887
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94240896
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.93695385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.88925202
2MP0004859_abnormal_synaptic_plasticity4.30200393
3MP0003195_calcinosis3.51997513
4MP0002735_abnormal_chemical_nociception3.35391433
5MP0003635_abnormal_synaptic_transmissio3.34500876
6MP0004270_analgesia3.31099611
7MP0010234_abnormal_vibrissa_follicle3.29241201
8MP0001968_abnormal_touch/_nociception3.26131550
9MP0009745_abnormal_behavioral_response3.04185897
10MP0002736_abnormal_nociception_after3.00806924
11MP0009046_muscle_twitch2.89979588
12MP0002063_abnormal_learning/memory/cond2.81845403
13MP0002064_seizures2.79361464
14MP0002734_abnormal_mechanical_nocicepti2.67947018
15MP0006276_abnormal_autonomic_nervous2.65857879
16MP0002272_abnormal_nervous_system2.55236431
17MP0002572_abnormal_emotion/affect_behav2.54621008
18MP0003787_abnormal_imprinting2.49418847
19MP0002102_abnormal_ear_morphology2.34894719
20MP0005646_abnormal_pituitary_gland2.34254373
21MP0001986_abnormal_taste_sensitivity2.28059544
22MP0001984_abnormal_olfaction2.27746231
23MP0002822_catalepsy2.13917692
24MP0001188_hyperpigmentation2.13865017
25MP0001501_abnormal_sleep_pattern2.11874245
26MP0000516_abnormal_urinary_system2.06057126
27MP0005367_renal/urinary_system_phenotyp2.06057126
28MP0001486_abnormal_startle_reflex2.06005698
29MP0003283_abnormal_digestive_organ2.05135174
30MP0002067_abnormal_sensory_capabilities2.02745290
31MP0006072_abnormal_retinal_apoptosis2.00862513
32MP0001970_abnormal_pain_threshold1.99539925
33MP0003122_maternal_imprinting1.95691789
34MP0002733_abnormal_thermal_nociception1.94395232
35MP0005423_abnormal_somatic_nervous1.87659430
36MP0004858_abnormal_nervous_system1.83452897
37MP0005645_abnormal_hypothalamus_physiol1.77688889
38MP0002184_abnormal_innervation1.76662880
39MP0002876_abnormal_thyroid_physiology1.74656121
40MP0003123_paternal_imprinting1.69903052
41MP0001944_abnormal_pancreas_morphology1.68297400
42MP0001529_abnormal_vocalization1.68198575
43MP0003879_abnormal_hair_cell1.66590513
44MP0001440_abnormal_grooming_behavior1.65045870
45MP0008569_lethality_at_weaning1.63145759
46MP0009780_abnormal_chondrocyte_physiolo1.61750680
47MP0001905_abnormal_dopamine_level1.60287917
48MP0010386_abnormal_urinary_bladder1.58763832
49MP0002557_abnormal_social/conspecific_i1.57342775
50MP0004142_abnormal_muscle_tone1.56442993
51MP0002693_abnormal_pancreas_physiology1.53840152
52MP0005253_abnormal_eye_physiology1.52857260
53MP0004924_abnormal_behavior1.52633365
54MP0005386_behavior/neurological_phenoty1.52633365
55MP0000778_abnormal_nervous_system1.48484703
56MP0003183_abnormal_peptide_metabolism1.48318566
57MP0004811_abnormal_neuron_physiology1.45306659
58MP0005220_abnormal_exocrine_pancreas1.39526633
59MP0001502_abnormal_circadian_rhythm1.34016248
60MP0002090_abnormal_vision1.33886637
61MP0005171_absent_coat_pigmentation1.30196239
62MP0005394_taste/olfaction_phenotype1.27221969
63MP0005499_abnormal_olfactory_system1.27221969
64MP0002938_white_spotting1.25392829
65MP0000955_abnormal_spinal_cord1.24653761
66MP0000427_abnormal_hair_cycle1.22835835
67MP0002882_abnormal_neuron_morphology1.22153580
68MP0004043_abnormal_pH_regulation1.19075647
69MP0002066_abnormal_motor_capabilities/c1.15663253
70MP0002837_dystrophic_cardiac_calcinosis1.14008791
71MP0010678_abnormal_skin_adnexa1.12146769
72MP0006036_abnormal_mitochondrial_physio1.09749687
73MP0005332_abnormal_amino_acid1.09455510
74MP0005075_abnormal_melanosome_morpholog1.08763955
75MP0001963_abnormal_hearing_physiology1.03586710
76MP0002909_abnormal_adrenal_gland1.03387798
77MP0002751_abnormal_autonomic_nervous1.03203674
78MP0002078_abnormal_glucose_homeostasis1.02592424
79MP0010329_abnormal_lipoprotein_level1.01266425
80MP0000015_abnormal_ear_pigmentation1.00579235
81MP0003633_abnormal_nervous_system1.00061568
82MP0008789_abnormal_olfactory_epithelium0.96170281
83MP0001756_abnormal_urination0.95487629
84MP0002928_abnormal_bile_duct0.94933849
85MP0000639_abnormal_adrenal_gland0.94851291
86MP0004742_abnormal_vestibular_system0.94524291
87MP0004085_abnormal_heartbeat0.94236931
88MP0002254_reproductive_system_inflammat0.93354835
89MP0000372_irregular_coat_pigmentation0.93029437
90MP0000538_abnormal_urinary_bladder0.91907042
91MP0003786_premature_aging0.91854729
92MP0005636_abnormal_mineral_homeostasis0.91507115
93MP0001485_abnormal_pinna_reflex0.88642728
94MP0002229_neurodegeneration0.87110236
95MP0004133_heterotaxia0.87070158
96MP0005187_abnormal_penis_morphology0.86278132
97MP0004484_altered_response_of0.85898970
98MP0003646_muscle_fatigue0.85419045
99MP0006054_spinal_hemorrhage0.85080552
100MP0000631_abnormal_neuroendocrine_gland0.84201036
101MP0003631_nervous_system_phenotype0.83489511
102MP0001177_atelectasis0.83053245
103MP0008877_abnormal_DNA_methylation0.82494056
104MP0002638_abnormal_pupillary_reflex0.82262795
105MP0000569_abnormal_digit_pigmentation0.81709792
106MP0003121_genomic_imprinting0.80739611
107MP0002009_preneoplasia0.79950835
108MP0003137_abnormal_impulse_conducting0.79592410
109MP0002069_abnormal_eating/drinking_beha0.79554105
110MP0008872_abnormal_physiological_respon0.79405410
111MP0000751_myopathy0.79301520
112MP0003172_abnormal_lysosome_physiology0.78964707
113MP0001661_extended_life_span0.78207936
114MP0002234_abnormal_pharynx_morphology0.78121448
115MP0004885_abnormal_endolymph0.77867543
116MP0005389_reproductive_system_phenotype0.77782576
117MP0002752_abnormal_somatic_nervous0.76656593
118MP0005535_abnormal_body_temperature0.76577043
119MP0002163_abnormal_gland_morphology0.76101365
120MP0000013_abnormal_adipose_tissue0.75126587
121MP0003329_amyloid_beta_deposits0.74718668
122MP0002152_abnormal_brain_morphology0.74478341
123MP0008995_early_reproductive_senescence0.73604086
124MP0004145_abnormal_muscle_electrophysio0.72878280
125MP0005551_abnormal_eye_electrophysiolog0.72406509
126MP0005084_abnormal_gallbladder_morpholo0.71239615
127MP0001664_abnormal_digestion0.70775645
128MP0005409_darkened_coat_color0.67622084
129MP0000026_abnormal_inner_ear0.66464081
130MP0005379_endocrine/exocrine_gland_phen0.63810395
131MP0008874_decreased_physiological_sensi0.63372479
132MP0003634_abnormal_glial_cell0.57564595
133MP0001943_abnormal_respiration0.56830695
134MP0004215_abnormal_myocardial_fiber0.54967480
135MP0000681_abnormal_thyroid_gland0.54328632
136MP0002160_abnormal_reproductive_system0.54272034
137MP0004147_increased_porphyrin_level0.52895665
138MP0005310_abnormal_salivary_gland0.51060678
139MP0000920_abnormal_myelination0.50455810

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.67129749
2Febrile seizures (HP:0002373)5.69558305
3Atonic seizures (HP:0010819)5.67870609
4Epileptic encephalopathy (HP:0200134)5.04065413
5Hyperinsulinemic hypoglycemia (HP:0000825)4.85274769
6Hypoglycemic seizures (HP:0002173)4.83033443
7Focal seizures (HP:0007359)4.72578472
8Myokymia (HP:0002411)4.68245953
9Hypoglycemic coma (HP:0001325)4.57670774
10Abnormal hair whorl (HP:0010721)4.42673658
11Ketoacidosis (HP:0001993)4.17839177
12Hyperventilation (HP:0002883)4.07323704
13Absence seizures (HP:0002121)3.99653096
14Neoplasm of the adrenal cortex (HP:0100641)3.87898796
15Hyperglycemia (HP:0003074)3.76675404
16Dialeptic seizures (HP:0011146)3.75590147
17Visual hallucinations (HP:0002367)3.70606070
18Progressive cerebellar ataxia (HP:0002073)3.68564278
19Abnormality of the pancreatic islet cells (HP:0006476)3.48656596
20Abnormality of endocrine pancreas physiology (HP:0012093)3.48656596
21Pheochromocytoma (HP:0002666)3.44592223
22Failure to thrive in infancy (HP:0001531)3.40679855
23Gait imbalance (HP:0002141)3.34917839
24Generalized tonic-clonic seizures (HP:0002069)3.34587352
25Medial flaring of the eyebrow (HP:0010747)3.25116770
26Neuroendocrine neoplasm (HP:0100634)3.23178643
27Symptomatic seizures (HP:0011145)3.18370342
28Congenital primary aphakia (HP:0007707)3.14942065
29Nephrogenic diabetes insipidus (HP:0009806)3.08846888
30Large for gestational age (HP:0001520)3.04828012
31Neoplasm of the adrenal gland (HP:0100631)2.97524718
32Gaze-evoked nystagmus (HP:0000640)2.96170651
33Broad-based gait (HP:0002136)2.95728425
34Hypomagnesemia (HP:0002917)2.92770662
35Hemiparesis (HP:0001269)2.91495543
36Methylmalonic acidemia (HP:0002912)2.90955871
37Fetal akinesia sequence (HP:0001989)2.85320602
38Pancreatic islet-cell hyperplasia (HP:0004510)2.84996812
39Amblyopia (HP:0000646)2.80731773
40Prominent metopic ridge (HP:0005487)2.79428963
41Ketosis (HP:0001946)2.77016788
42Poor suck (HP:0002033)2.75135914
43Abnormality of the metopic suture (HP:0005556)2.66384554
44Limb dystonia (HP:0002451)2.63177467
45Pancreatic cysts (HP:0001737)2.61901141
46Progressive inability to walk (HP:0002505)2.61137081
47Abnormal eating behavior (HP:0100738)2.60843871
48Intestinal atresia (HP:0011100)2.60661587
49Enlarged penis (HP:0000040)2.60593091
50Truncal ataxia (HP:0002078)2.58403364
51Hamartoma of the eye (HP:0010568)2.57120160
52Insulin-resistant diabetes mellitus (HP:0000831)2.56519137
53Abnormality of vitamin B metabolism (HP:0004340)2.50942909
54Genital tract atresia (HP:0001827)2.48788377
55Acute necrotizing encephalopathy (HP:0006965)2.48732718
56Action tremor (HP:0002345)2.43092922
57Polyphagia (HP:0002591)2.42786511
58Anxiety (HP:0000739)2.42494715
59Aqueductal stenosis (HP:0002410)2.40992960
60Progressive macrocephaly (HP:0004481)2.40935081
61Abnormal mitochondria in muscle tissue (HP:0008316)2.40826606
62Poor coordination (HP:0002370)2.40736270
63Oligomenorrhea (HP:0000876)2.39082894
64Ankle clonus (HP:0011448)2.36702205
65Blue irides (HP:0000635)2.36345184
66Vaginal atresia (HP:0000148)2.35793373
67Conjunctival hamartoma (HP:0100780)2.35265014
68Thyroiditis (HP:0100646)2.34405677
69Specific learning disability (HP:0001328)2.32963598
70Muscular hypotonia of the trunk (HP:0008936)2.31118433
71Hepatic necrosis (HP:0002605)2.30440512
72Nephronophthisis (HP:0000090)2.26515545
73Abnormality of the renal cortex (HP:0011035)2.25865414
74Abnormality of midbrain morphology (HP:0002418)2.23839413
75Molar tooth sign on MRI (HP:0002419)2.23839413
76Epileptiform EEG discharges (HP:0011182)2.22951753
77Drooling (HP:0002307)2.22749582
78Excessive salivation (HP:0003781)2.22749582
79Abnormal drinking behavior (HP:0030082)2.18548633
80Polydipsia (HP:0001959)2.18548633
81True hermaphroditism (HP:0010459)2.18470047
82Abnormality of the labia minora (HP:0012880)2.17551001
83Impaired vibration sensation in the lower limbs (HP:0002166)2.17532876
84Increased circulating renin level (HP:0000848)2.16823813
85Hypoventilation (HP:0002791)2.16073156
86Methylmalonic aciduria (HP:0012120)2.16054305
87Depression (HP:0000716)2.15181085
88Protruding tongue (HP:0010808)2.15117117
89Abnormality of pain sensation (HP:0010832)2.13458552
90Impaired pain sensation (HP:0007328)2.13458552
91Scanning speech (HP:0002168)2.12464743
92Dysdiadochokinesis (HP:0002075)2.11065486
93Narrow nasal bridge (HP:0000446)2.10347915
94Absent speech (HP:0001344)2.10055953
95Late onset (HP:0003584)2.09429589
96Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09118014
97Breast carcinoma (HP:0003002)2.08564602
98Inability to walk (HP:0002540)2.08482980
99Double outlet right ventricle (HP:0001719)2.05458364
100Congenital malformation of the right heart (HP:0011723)2.05458364
101Abnormality of magnesium homeostasis (HP:0004921)2.03650961
102Acute encephalopathy (HP:0006846)2.01223219
103Intention tremor (HP:0002080)2.01158520
104Renal cortical cysts (HP:0000803)2.00534048
105Aplasia/Hypoplasia of the lens (HP:0008063)2.00318913
106Akinesia (HP:0002304)1.98925641
107Hematochezia (HP:0002573)1.98705998
108Furrowed tongue (HP:0000221)1.98415604
109Menstrual irregularities (HP:0000858)1.98029291
110Poor eye contact (HP:0000817)1.97588792
111Metaphyseal dysplasia (HP:0100255)1.96746300
112EEG with generalized epileptiform discharges (HP:0011198)1.96339477
113Congenital stationary night blindness (HP:0007642)1.96223104
114Abnormality of methionine metabolism (HP:0010901)1.95221001
115Ependymoma (HP:0002888)1.93677239
116Disproportionate short-trunk short stature (HP:0003521)1.93620933
117Heterochromia iridis (HP:0001100)1.93396599
118* Hypothermia (HP:0002045)1.93227450
119Mitochondrial inheritance (HP:0001427)1.93125293
120Hypoplasia of the fovea (HP:0007750)1.92952452
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.92952452
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92603612
123Thyroid carcinoma (HP:0002890)1.92012701
124Sleep apnea (HP:0010535)1.89797209
125Calf muscle hypertrophy (HP:0008981)1.89666722
126Abnormality of the renal medulla (HP:0100957)1.88921115
127Astrocytoma (HP:0009592)1.88064090
128Abnormality of the astrocytes (HP:0100707)1.88064090
129Spinal canal stenosis (HP:0003416)1.87595318
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.85434867
131Esotropia (HP:0000565)1.83405595
132Urinary bladder sphincter dysfunction (HP:0002839)1.82784192
133Type II lissencephaly (HP:0007260)1.80998422
134Abnormality of vitamin metabolism (HP:0100508)1.80217960
135Bradykinesia (HP:0002067)1.78448416
136Hypsarrhythmia (HP:0002521)1.78153727
137Retinal dysplasia (HP:0007973)1.77923578
138Neoplasm of the peripheral nervous system (HP:0100007)1.77682307
139Generalized hypotonia (HP:0001290)1.77071900
140Abnormal pancreas size (HP:0012094)1.76807560
141Generalized myoclonic seizures (HP:0002123)1.76709443
142Hepatocellular necrosis (HP:0001404)1.75604219
143Genetic anticipation (HP:0003743)1.75171668
144Left ventricular hypertrophy (HP:0001712)1.74141444
145Hypokinesia (HP:0002375)1.73492947
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72936640
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.72936640
148Dysmetria (HP:0001310)1.72797116
149Supranuclear gaze palsy (HP:0000605)1.72642940
150Cutaneous melanoma (HP:0012056)1.72389642
151Lower limb muscle weakness (HP:0007340)1.71155576
152Muscle hypertrophy of the lower extremities (HP:0008968)1.70664919
153Psychosis (HP:0000709)1.70644925
154Downturned corners of mouth (HP:0002714)1.69876131
155Agitation (HP:0000713)1.69846870
156Increased CSF lactate (HP:0002490)1.68907719
157Termporal pattern (HP:0011008)1.68865527
158Insidious onset (HP:0003587)1.68865527
159Abnormality of the corticospinal tract (HP:0002492)1.67874863
160Hip dysplasia (HP:0001385)1.67457539
161Palpebral edema (HP:0100540)1.66989380
162Abnormality of salivation (HP:0100755)1.66987112
163Spastic gait (HP:0002064)1.66827835
164Incomplete penetrance (HP:0003829)1.66647102
165Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65299858
166Diminished movement (HP:0002374)1.64926406
167Torticollis (HP:0000473)1.64376890
168Impaired social interactions (HP:0000735)1.63038290
169Abnormal social behavior (HP:0012433)1.63038290
170Delayed gross motor development (HP:0002194)1.62716630
171Pancreatic fibrosis (HP:0100732)1.61988583
172Stereotypic behavior (HP:0000733)1.60399663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.51130166
2MAP3K123.83562094
3NTRK33.56258183
4FGFR23.34584323
5MAP2K73.26680757
6SIK33.04066330
7PRPF4B2.97644862
8TRIM282.70672379
9MAP3K42.58767192
10AKT32.42466586
11MST42.40416601
12MINK12.38367678
13MAP4K22.25876249
14EPHA42.22860098
15SGK22.18834815
16PLK22.09750522
17BMPR22.05759499
18ACVR1B2.01837862
19NUAK11.98348078
20GRK11.90676690
21MKNK21.89305848
22SGK2231.84634955
23SGK4941.84634955
24MAPK131.70353898
25DAPK21.68151373
26RIPK41.62838255
27CDK191.59815375
28ARAF1.56752551
29STK391.56321598
30CSNK1G11.54969463
31MAP2K41.52814895
32ERBB31.50403168
33BCR1.47472797
34DAPK11.46420487
35PLK31.45056672
36MAP3K91.40816476
37MARK11.40291622
38EIF2AK31.38548800
39TNIK1.37229369
40SGK31.36398384
41CSNK1G31.30967215
42GRK51.25853855
43GRK71.24746108
44KSR11.21052194
45MYLK1.11593438
46ADRBK21.10509088
47INSRR1.07971551
48YES11.07712362
49NLK1.03913022
50STK38L1.03893947
51CCNB11.00010064
52PRKCG0.99321070
53CDK50.98436587
54OXSR10.97399734
55NTRK20.95629771
56CAMK2A0.95588593
57BRAF0.95327146
58CAMKK20.95230095
59NTRK10.94038632
60MAP3K140.93963375
61ZAK0.93162007
62FGFR30.92863485
63PRKCE0.88286725
64CSNK1A1L0.88007322
65TSSK60.86837132
66BMPR1B0.83479092
67MKNK10.81596059
68PASK0.79438290
69TNK20.78347081
70PRKCH0.77614123
71FRK0.74560566
72RPS6KA20.73075920
73CAMK2B0.72711595
74WNK40.71257619
75PINK10.68472606
76MAP3K130.67746692
77BRSK20.67464792
78STK240.67353968
79STK30.65331850
80UHMK10.64983041
81MUSK0.64732589
82EIF2AK10.63148054
83CDK80.62202466
84PTK2B0.61345924
85OBSCN0.61247210
86SGK10.60906407
87LMTK20.60282222
88ADRBK10.60012489
89PAK60.59946647
90FES0.59539668
91NEK60.58302081
92CDK180.57205575
93PRKCI0.55689577
94DYRK1A0.55416544
95MAP3K20.54963611
96KSR20.54627721
97STK110.53556909
98MAP2K10.53434032
99CAMKK10.52423821
100MAPKAPK30.52411876
101PRKAA10.50841799
102PRKAA20.50230222
103CAMK2D0.49312427
104CDK140.46993564
105CAMK2G0.45363612
106PNCK0.44956851
107MAP3K10.43082207
108CSNK1A10.42094580
109TAF10.42004014
110VRK10.41685466
111CAMK10.41250067
112CDK150.38733696
113FER0.37317397
114ROCK10.37283041
115CDK30.37024402
116STK160.36780925
117MAPKAPK50.36578989
118RPS6KB10.36385062
119CSNK1D0.36111291
120NME10.36007274
121MAP2K60.35875855
122TXK0.35772246
123LIMK10.35496436
124HIPK20.35185804
125PRKCZ0.34689474
126PAK30.34506797
127TRPM70.34246432
128PRKD30.33863278
129SIK20.33552005
130PHKG20.33310085
131PHKG10.33310085
132CAMK40.33171136
133WNK10.33038128
134PRKACA0.32925879
135BUB10.32482979
136MAP3K60.31723876
137CSNK1G20.31689273
138PLK10.31097003
139WNK30.30272562
140CDK11A0.29898130
141BCKDK0.29439050
142EPHA30.29308474
143RPS6KL10.28838974
144RPS6KC10.28838974
145PRKG10.28469525

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.70024175
2Synaptic vesicle cycle_Homo sapiens_hsa047213.72615838
3Nicotine addiction_Homo sapiens_hsa050333.39458484
4Protein export_Homo sapiens_hsa030603.18499933
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14717660
6Olfactory transduction_Homo sapiens_hsa047402.93331559
7Collecting duct acid secretion_Homo sapiens_hsa049662.92497057
8Butanoate metabolism_Homo sapiens_hsa006502.77451802
9Vitamin B6 metabolism_Homo sapiens_hsa007502.75315190
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53901900
11Circadian entrainment_Homo sapiens_hsa047132.45866548
12Morphine addiction_Homo sapiens_hsa050322.41395088
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40824615
14GABAergic synapse_Homo sapiens_hsa047272.35835359
15Long-term potentiation_Homo sapiens_hsa047202.22977379
16Amphetamine addiction_Homo sapiens_hsa050312.17733421
17Dopaminergic synapse_Homo sapiens_hsa047282.11426972
18Taste transduction_Homo sapiens_hsa047422.06562827
19Propanoate metabolism_Homo sapiens_hsa006402.04493939
20Glutamatergic synapse_Homo sapiens_hsa047242.03121033
21Vibrio cholerae infection_Homo sapiens_hsa051102.01504412
22Fatty acid elongation_Homo sapiens_hsa000621.93999350
23Serotonergic synapse_Homo sapiens_hsa047261.93182423
24Insulin secretion_Homo sapiens_hsa049111.78611022
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71488223
26Cholinergic synapse_Homo sapiens_hsa047251.70760190
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66843693
28Salivary secretion_Homo sapiens_hsa049701.60931773
29Oxidative phosphorylation_Homo sapiens_hsa001901.54705190
30Long-term depression_Homo sapiens_hsa047301.52609616
31Renin secretion_Homo sapiens_hsa049241.51326735
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50509397
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48856639
34Calcium signaling pathway_Homo sapiens_hsa040201.47067633
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46220481
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41269699
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40660129
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37439789
39Rheumatoid arthritis_Homo sapiens_hsa053231.37099547
40Cocaine addiction_Homo sapiens_hsa050301.36751511
41Selenocompound metabolism_Homo sapiens_hsa004501.33928288
42Tryptophan metabolism_Homo sapiens_hsa003801.32617942
43Gastric acid secretion_Homo sapiens_hsa049711.31832536
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30685222
45Phototransduction_Homo sapiens_hsa047441.30163824
46Oxytocin signaling pathway_Homo sapiens_hsa049211.28863946
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27994024
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25333901
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24689142
50Peroxisome_Homo sapiens_hsa041461.22885923
51Sulfur metabolism_Homo sapiens_hsa009201.17774676
52Steroid biosynthesis_Homo sapiens_hsa001001.15949427
53Fatty acid metabolism_Homo sapiens_hsa012121.14223949
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11032574
55Alzheimers disease_Homo sapiens_hsa050101.10484688
56Type I diabetes mellitus_Homo sapiens_hsa049401.10401022
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09344403
58Parkinsons disease_Homo sapiens_hsa050121.08717516
59cAMP signaling pathway_Homo sapiens_hsa040241.07585302
60GnRH signaling pathway_Homo sapiens_hsa049121.07457821
61Phagosome_Homo sapiens_hsa041451.02326178
62Ether lipid metabolism_Homo sapiens_hsa005651.01154646
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00802381
64Basal transcription factors_Homo sapiens_hsa030220.99829273
65Non-homologous end-joining_Homo sapiens_hsa034500.98987203
66beta-Alanine metabolism_Homo sapiens_hsa004100.98081311
67ErbB signaling pathway_Homo sapiens_hsa040120.96450391
68Fatty acid degradation_Homo sapiens_hsa000710.94805179
69Gap junction_Homo sapiens_hsa045400.93479292
70RNA degradation_Homo sapiens_hsa030180.89670359
71Cardiac muscle contraction_Homo sapiens_hsa042600.88628086
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88362465
73Axon guidance_Homo sapiens_hsa043600.88153491
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87503737
75Nitrogen metabolism_Homo sapiens_hsa009100.85244173
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84490975
77Proteasome_Homo sapiens_hsa030500.84463252
78Folate biosynthesis_Homo sapiens_hsa007900.83898378
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.83746353
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83151020
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.82326178
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80709085
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80071248
84MAPK signaling pathway_Homo sapiens_hsa040100.78938353
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78092705
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76458909
87RNA polymerase_Homo sapiens_hsa030200.75811475
88Melanogenesis_Homo sapiens_hsa049160.74799093
89Mineral absorption_Homo sapiens_hsa049780.73059568
90Huntingtons disease_Homo sapiens_hsa050160.72837027
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72178290
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.70458309
93Glioma_Homo sapiens_hsa052140.70128145
94Type II diabetes mellitus_Homo sapiens_hsa049300.69837829
95Estrogen signaling pathway_Homo sapiens_hsa049150.67296925
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66052389
97Caffeine metabolism_Homo sapiens_hsa002320.65923782
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65872728
99Linoleic acid metabolism_Homo sapiens_hsa005910.65256119
100Ras signaling pathway_Homo sapiens_hsa040140.65231071
101Dilated cardiomyopathy_Homo sapiens_hsa054140.61544098
102Sphingolipid metabolism_Homo sapiens_hsa006000.61151746
103Circadian rhythm_Homo sapiens_hsa047100.58966931
104Inositol phosphate metabolism_Homo sapiens_hsa005620.57392480
105Chemokine signaling pathway_Homo sapiens_hsa040620.57145965
106Ovarian steroidogenesis_Homo sapiens_hsa049130.56179667
107Metabolic pathways_Homo sapiens_hsa011000.54231266
108Regulation of autophagy_Homo sapiens_hsa041400.53394829
109Endometrial cancer_Homo sapiens_hsa052130.53019439
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52052185
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51762603
112Oocyte meiosis_Homo sapiens_hsa041140.49941531
113Purine metabolism_Homo sapiens_hsa002300.49602204
114Melanoma_Homo sapiens_hsa052180.49259148
115Pyruvate metabolism_Homo sapiens_hsa006200.49191526
116Pancreatic secretion_Homo sapiens_hsa049720.48740380
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.47860468
118Salmonella infection_Homo sapiens_hsa051320.47587296
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47586665
120Alcoholism_Homo sapiens_hsa050340.47343837
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45887856
122Arginine and proline metabolism_Homo sapiens_hsa003300.45447551
123Prolactin signaling pathway_Homo sapiens_hsa049170.44774038
124ABC transporters_Homo sapiens_hsa020100.44397604
125Fanconi anemia pathway_Homo sapiens_hsa034600.42500912
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42304697
127Homologous recombination_Homo sapiens_hsa034400.41975174
128Rap1 signaling pathway_Homo sapiens_hsa040150.41600413
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.40151306
130Choline metabolism in cancer_Homo sapiens_hsa052310.40024700
131Thyroid hormone synthesis_Homo sapiens_hsa049180.39650165
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39411921
133Endocytosis_Homo sapiens_hsa041440.38479973
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38401618
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.38100226
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37733965
137Dorso-ventral axis formation_Homo sapiens_hsa043200.37184384
138Tuberculosis_Homo sapiens_hsa051520.37086044
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35902434
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35541727
141Glucagon signaling pathway_Homo sapiens_hsa049220.33542089
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31987533
143Wnt signaling pathway_Homo sapiens_hsa043100.30824010
144Allograft rejection_Homo sapiens_hsa053300.30661605
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30497857
146Colorectal cancer_Homo sapiens_hsa052100.30491341
147African trypanosomiasis_Homo sapiens_hsa051430.30030759
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28048746
149Autoimmune thyroid disease_Homo sapiens_hsa053200.27056073
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27003287
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26978667

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »