TSPY8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mesoderm development (GO:0007498)7.90128474
2* mesenchyme development (GO:0060485)7.35835179
3sex differentiation (GO:0007548)6.53138334
4* gonadal mesoderm development (GO:0007506)58.6951161
5N-acetylneuraminate metabolic process (GO:0006054)5.18450009
6* nucleosome assembly (GO:0006334)4.82778262
7* protein-DNA complex assembly (GO:0065004)4.18685138
8* nucleosome organization (GO:0034728)3.92412792
9ribosomal small subunit assembly (GO:0000028)3.74111079
10ribosomal small subunit biogenesis (GO:0042274)3.70008768
11* protein-DNA complex subunit organization (GO:0071824)3.50609663
12piRNA metabolic process (GO:0034587)3.22747620
13regulation of meiosis I (GO:0060631)3.13346925
14regulation of activation of Janus kinase activity (GO:0010533)2.68244057
15positive regulation of translational initiation (GO:0045948)2.67299358
16mitotic chromosome condensation (GO:0007076)2.58823586
17formation of translation preinitiation complex (GO:0001731)2.58630354
18interleukin-6-mediated signaling pathway (GO:0070102)2.53225024
19positive regulation of meiosis (GO:0045836)2.50156128
20viral transcription (GO:0019083)2.46047906
21positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.44526933
22mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.44526933
23translational termination (GO:0006415)2.41157821
24positive regulation of meiotic cell cycle (GO:0051446)2.32992957
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.31266731
26cotranslational protein targeting to membrane (GO:0006613)2.26911309
27meiotic chromosome segregation (GO:0045132)2.25409818
28protein localization to endoplasmic reticulum (GO:0070972)2.24969009
29translational elongation (GO:0006414)2.24703651
30protein targeting to ER (GO:0045047)2.23253964
31regulation of isotype switching to IgG isotypes (GO:0048302)2.22924956
32establishment of protein localization to endoplasmic reticulum (GO:0072599)2.15262326
33apoptotic cell clearance (GO:0043277)2.06480898
34protein K63-linked deubiquitination (GO:0070536)2.04060671
35viral life cycle (GO:0019058)2.03809565
36positive regulation of viral genome replication (GO:0045070)2.02388946
37translational initiation (GO:0006413)2.00380608
38mitotic metaphase plate congression (GO:0007080)1.99741065
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)1.99161504
40synapsis (GO:0007129)1.97933287
41ribonucleoprotein complex biogenesis (GO:0022613)1.97360937
42protein K48-linked deubiquitination (GO:0071108)1.97026147
43positive regulation of inflammatory response to antigenic stimulus (GO:0002863)1.96667978
44* male gamete generation (GO:0048232)1.96358621
45* spermatogenesis (GO:0007283)1.96336819
46male meiosis (GO:0007140)1.95331167
47Golgi transport vesicle coating (GO:0048200)1.95078739
48COPI coating of Golgi vesicle (GO:0048205)1.95078739
49sialylation (GO:0097503)1.94399637
50establishment of integrated proviral latency (GO:0075713)1.91590474
51negative regulation of meiosis (GO:0045835)1.90952579
52mitotic sister chromatid cohesion (GO:0007064)1.90825553
53cellular protein complex disassembly (GO:0043624)1.86161610
54nucleotide transmembrane transport (GO:1901679)1.81878461
55* gamete generation (GO:0007276)1.79708562
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.74790935
57regulation of translational initiation (GO:0006446)1.70686237
58protein targeting to membrane (GO:0006612)1.70559684
59ribosome biogenesis (GO:0042254)1.70139592
60nucleotide transport (GO:0006862)1.69084018
61negative regulation of Notch signaling pathway (GO:0045746)1.67257520
62proline biosynthetic process (GO:0006561)1.66545250
63protein K6-linked ubiquitination (GO:0085020)1.62881529
64* reproductive structure development (GO:0048608)1.62610017
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)1.62133505
66regulation of translational fidelity (GO:0006450)1.61828149
67gene silencing by RNA (GO:0031047)1.60260235
68regulation of meiosis (GO:0040020)1.59255697
69protein complex disassembly (GO:0043241)1.57923983
70translation (GO:0006412)1.57710419
71positive regulation of alpha-beta T cell proliferation (GO:0046641)1.57544928
72chaperone mediated protein folding requiring cofactor (GO:0051085)1.57436601
73viral protein processing (GO:0019082)1.57022693
74proteasome assembly (GO:0043248)1.56874451
75male sex determination (GO:0030238)1.55834292
76DNA catabolic process, exonucleolytic (GO:0000738)1.55626679
77cellular response to interleukin-6 (GO:0071354)1.55553288
78germ cell migration (GO:0008354)1.54949783
79ncRNA 3-end processing (GO:0043628)1.52868832
80protein N-linked glycosylation via asparagine (GO:0018279)1.52317600
81chromosome organization involved in meiosis (GO:0070192)1.50000770
82male meiosis I (GO:0007141)1.49955348
83DNA strand elongation involved in DNA replication (GO:0006271)1.49850331
84peptidyl-asparagine modification (GO:0018196)1.49820405
85organ or tissue specific immune response (GO:0002251)1.49717560
86meiotic nuclear division (GO:0007126)1.49490037
87DNA strand elongation (GO:0022616)1.48982204
88DNA replication initiation (GO:0006270)1.48143571
89somatic hypermutation of immunoglobulin genes (GO:0016446)1.48037405
90somatic diversification of immune receptors via somatic mutation (GO:0002566)1.48037405
91regulation of sister chromatid cohesion (GO:0007063)1.47419661
92sodium ion homeostasis (GO:0055078)1.47143520
93macromolecular complex disassembly (GO:0032984)1.46466682
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)1.46243224
95cellular sodium ion homeostasis (GO:0006883)1.45903409
96metaphase plate congression (GO:0051310)1.45794999
97negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.45624488
98regulation of penile erection (GO:0060405)1.45251197
99N-terminal protein amino acid acetylation (GO:0006474)1.44786109
100purine ribonucleotide transport (GO:0015868)1.44743294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40829309
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00774289
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.87111988
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.82565113
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.74449753
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.17593936
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14890021
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10534421
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02956439
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.91035690
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84891662
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80721000
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.68206646
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.63831880
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59057376
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54765482
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49204312
18TFEB_21752829_ChIP-Seq_HELA_Human2.45853095
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41986106
20DCP1A_22483619_ChIP-Seq_HELA_Human2.41927860
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40054358
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.28271376
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19218998
24TTF2_22483619_ChIP-Seq_HELA_Human2.16253964
25VDR_23849224_ChIP-Seq_CD4+_Human2.15959718
26IGF1R_20145208_ChIP-Seq_DFB_Human2.15400638
27ZFX_18555785_ChIP-Seq_MESCs_Mouse2.15276135
28GABP_19822575_ChIP-Seq_HepG2_Human2.05694157
29FOXP3_21729870_ChIP-Seq_TREG_Human2.04878315
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03695905
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97728358
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95889897
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.95166825
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92692222
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89503043
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88763932
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87953702
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82941377
39SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.79615470
40XRN2_22483619_ChIP-Seq_HELA_Human1.78188498
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.77842920
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74588369
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68780812
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.64358894
45CIITA_25753668_ChIP-Seq_RAJI_Human1.63137177
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62019379
47ELK1_19687146_ChIP-ChIP_HELA_Human1.61426365
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61127373
49MYC_22102868_ChIP-Seq_BL_Human1.60876952
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59907404
51CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58092943
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53360928
53KDM5A_27292631_Chip-Seq_BREAST_Human1.52153338
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50184461
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46038330
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42672404
57CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.41658677
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41320811
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41286320
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39058410
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39045184
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38494333
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36601079
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.36546712
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35019029
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33865229
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29927479
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.26265084
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24465122
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23806253
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23311951
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19934120
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19687075
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16517230
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16517230
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16517230
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06673821
78SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.03508516
79MYB_26560356_Chip-Seq_TH2_Human1.02941550
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01803027
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01802513
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98155394
83KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96804520
84TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96756351
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93476348
86ZNF263_19887448_ChIP-Seq_K562_Human0.92228065
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89265431
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87842340
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86801582
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.84202284
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81785121
92AR_21909140_ChIP-Seq_LNCAP_Human0.81563270
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81330997
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80755229
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79670739
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79010511
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78022221
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77653944
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76657259
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75885091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.70832706
2MP0003136_yellow_coat_color4.46613663
3MP0003693_abnormal_embryo_hatching4.09964667
4MP0005058_abnormal_lysosome_morphology3.72073676
5MP0004147_increased_porphyrin_level3.56398380
6MP0005171_absent_coat_pigmentation3.10120286
7MP0004957_abnormal_blastocyst_morpholog3.06770709
8MP0009333_abnormal_splenocyte_physiolog2.85078944
9MP0003111_abnormal_nucleus_morphology2.77119642
10MP0005174_abnormal_tail_pigmentation2.71144222
11MP0008995_early_reproductive_senescence2.67810835
12MP0008057_abnormal_DNA_replication2.44327788
13MP0003077_abnormal_cell_cycle2.22868697
14MP0002210_abnormal_sex_determination2.03657898
15MP0001929_abnormal_gametogenesis1.94691741
16MP0003183_abnormal_peptide_metabolism1.93655397
17MP0008932_abnormal_embryonic_tissue1.91425421
18MP0008058_abnormal_DNA_repair1.89939283
19MP0010368_abnormal_lymphatic_system1.81032689
20MP0005451_abnormal_body_composition1.80848000
21MP0001145_abnormal_male_reproductive1.80591542
22MP0001188_hyperpigmentation1.76493299
23MP0010307_abnormal_tumor_latency1.70719985
24MP0005075_abnormal_melanosome_morpholog1.65617436
25MP0008877_abnormal_DNA_methylation1.58565634
26MP0001730_embryonic_growth_arrest1.58495884
27MP0003786_premature_aging1.56323025
28MP0001348_abnormal_lacrimal_gland1.55802086
29MP0000350_abnormal_cell_proliferation1.53785317
30MP0000653_abnormal_sex_gland1.52680572
31MP0009840_abnormal_foam_cell1.51192450
32MP0003698_abnormal_male_reproductive1.51127740
33MP0005408_hypopigmentation1.50260379
34MP0005671_abnormal_response_to1.47700078
35MP0003806_abnormal_nucleotide_metabolis1.43129260
36MP0002877_abnormal_melanocyte_morpholog1.40909859
37MP0000747_muscle_weakness1.39147515
38MP0010094_abnormal_chromosome_stability1.35554532
39MP0002168_other_aberrant_phenotype1.34994590
40MP0000372_irregular_coat_pigmentation1.33467118
41MP0005395_other_phenotype1.26705391
42MP0003763_abnormal_thymus_physiology1.26565025
43MP0003172_abnormal_lysosome_physiology1.14799639
44MP0000313_abnormal_cell_death1.13950768
45MP0005670_abnormal_white_adipose1.13572900
46MP0002095_abnormal_skin_pigmentation1.13536428
47MP0002080_prenatal_lethality1.12014022
48MP0003718_maternal_effect1.08579777
49MP0008007_abnormal_cellular_replicative1.08050137
50MP0003656_abnormal_erythrocyte_physiolo1.06515141
51MP0000358_abnormal_cell_content/1.06427216
52MP0004043_abnormal_pH_regulation1.06163828
53MP0001663_abnormal_digestive_system1.05042954
54MP0001697_abnormal_embryo_size1.04576760
55MP0003186_abnormal_redox_activity1.01116541
56MP0005220_abnormal_exocrine_pancreas1.00594770
57MP0002075_abnormal_coat/hair_pigmentati0.97728505
58MP0008260_abnormal_autophagy0.97696991
59MP0003646_muscle_fatigue0.92351940
60MP0003943_abnormal_hepatobiliary_system0.91838139
61MP0001661_extended_life_span0.90898094
62MP0002161_abnormal_fertility/fecundity0.86456643
63MP0000689_abnormal_spleen_morphology0.85346070
64MP0005464_abnormal_platelet_physiology0.84636617
65MP0002398_abnormal_bone_marrow0.83309626
66MP0001186_pigmentation_phenotype0.83082533
67MP0002796_impaired_skin_barrier0.82571696
68MP0005381_digestive/alimentary_phenotyp0.81426754
69MP0004233_abnormal_muscle_weight0.79776410
70MP0009379_abnormal_foot_pigmentation0.78328556
71MP0006035_abnormal_mitochondrial_morpho0.78121943
72MP0008569_lethality_at_weaning0.77352030
73MP0003959_abnormal_lean_body0.76894359
74MP0002090_abnormal_vision0.75354181
75MP0002751_abnormal_autonomic_nervous0.74887182
76MP0003221_abnormal_cardiomyocyte_apopto0.72904070
77MP0002429_abnormal_blood_cell0.72882141
78MP0000703_abnormal_thymus_morphology0.72289644
79MP0001324_abnormal_eye_pigmentation0.71085835
80MP0001542_abnormal_bone_strength0.70364731
81MP0005410_abnormal_fertilization0.68642184
82MP0009643_abnormal_urine_homeostasis0.68539388
83MP0001666_abnormal_nutrient_absorption0.67455169
84MP0000598_abnormal_liver_morphology0.66352187
85MP0006036_abnormal_mitochondrial_physio0.64157802
86MP0000371_diluted_coat_color0.63925777
87MP0004215_abnormal_myocardial_fiber0.62736083
88MP0002019_abnormal_tumor_incidence0.62624169
89MP0004808_abnormal_hematopoietic_stem0.61928466
90MP0000716_abnormal_immune_system0.61770947
91MP0001919_abnormal_reproductive_system0.61006308
92MP0005384_cellular_phenotype0.60528449
93MP0002084_abnormal_developmental_patter0.60339732
94MP0002722_abnormal_immune_system0.60140556
95MP0009785_altered_susceptibility_to0.59466738
96MP0002822_catalepsy0.57820325
97MP0002086_abnormal_extraembryonic_tissu0.57694702
98MP0000490_abnormal_crypts_of0.57598316
99MP0001119_abnormal_female_reproductive0.57447511
100MP0004197_abnormal_fetal_growth/weight/0.57230301

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.62976178
2Carpal bone hypoplasia (HP:0001498)3.90672295
3Increased neuronal autofluorescent lipopigment (HP:0002074)3.81111628
4Back pain (HP:0003418)3.71467378
5Patchy hypopigmentation of hair (HP:0011365)3.69604910
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.66802040
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.66802040
8Increased cerebral lipofuscin (HP:0011813)3.65023637
9Reticulocytopenia (HP:0001896)3.44907241
10Vertebral compression fractures (HP:0002953)3.44529213
11Abnormal number of erythroid precursors (HP:0012131)3.41127199
12Abnormality of cells of the erythroid lineage (HP:0012130)3.28417213
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.23571655
14Abnormal auditory evoked potentials (HP:0006958)3.20171405
15Nonimmune hydrops fetalis (HP:0001790)3.17885593
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.17532440
17White forelock (HP:0002211)3.13060196
18Hypoplasia of the uterus (HP:0000013)3.09693190
19Albinism (HP:0001022)3.09427438
20Short middle phalanx of the 5th finger (HP:0004220)3.01237189
21Abnormality of glycolipid metabolism (HP:0010969)2.99793634
22Abnormality of liposaccharide metabolism (HP:0010968)2.99793634
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.99793634
24Abnormal glycosylation (HP:0012345)2.97842312
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.97842312
26Abnormal protein N-linked glycosylation (HP:0012347)2.97842312
27Abnormal protein glycosylation (HP:0012346)2.97842312
28Dysostosis multiplex (HP:0000943)2.97255911
29Type I transferrin isoform profile (HP:0003642)2.85236057
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85026528
31Acute hepatic failure (HP:0006554)2.84657457
32Large for gestational age (HP:0001520)2.77185280
33Abnormality of the corticospinal tract (HP:0002492)2.76835137
34Gonadal dysgenesis (HP:0000133)2.76225927
35Basal cell carcinoma (HP:0002671)2.73172508
36Decreased circulating renin level (HP:0003351)2.72227086
37Hyperactive renin-angiotensin system (HP:0000841)2.65400272
38Spastic paraparesis (HP:0002313)2.59243734
39Upper limb muscle weakness (HP:0003484)2.56446678
40Cutaneous melanoma (HP:0012056)2.53916818
41Abnormal tarsal ossification (HP:0008369)2.45333742
42Global brain atrophy (HP:0002283)2.44486415
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41369279
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41369279
45Reduced antithrombin III activity (HP:0001976)2.40172627
46Ankyloglossia (HP:0010296)2.37883094
47Hyperglycinuria (HP:0003108)2.36539735
48Hyperlipoproteinemia (HP:0010980)2.36421433
49Lower limb hyperreflexia (HP:0002395)2.32726087
50Exocrine pancreatic insufficiency (HP:0001738)2.30402033
51Hyponatremia (HP:0002902)2.28559597
52Aplasia/hypoplasia of the uterus (HP:0008684)2.25644244
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.23458153
54Autoimmune hemolytic anemia (HP:0001890)2.23002544
55Beaking of vertebral bodies (HP:0004568)2.22487119
56Volvulus (HP:0002580)2.19957250
57Small epiphyses (HP:0010585)2.17591008
58Squamous cell carcinoma (HP:0002860)2.15922180
59Macrocytic anemia (HP:0001972)2.14266933
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12981299
61Pallor (HP:0000980)2.12294475
62Overlapping toe (HP:0001845)2.09346604
63Osteomalacia (HP:0002749)2.05491990
64Urethral obstruction (HP:0000796)2.05197193
65Hypercortisolism (HP:0001578)2.04207736
66Microretrognathia (HP:0000308)2.03934791
67Exercise-induced myalgia (HP:0003738)2.03758652
68Chronic mucocutaneous candidiasis (HP:0002728)2.03620726
69Recurrent cutaneous fungal infections (HP:0011370)2.03620726
70CNS hypomyelination (HP:0003429)2.02841743
71Abnormality of the distal phalanges of the toes (HP:0010182)2.02637179
72Neoplasm of head and neck (HP:0012288)2.00188514
73Esophageal neoplasm (HP:0100751)2.00188514
74Abnormality of oral frenula (HP:0000190)1.98490901
75Abnormality of the lumbar spine (HP:0100712)1.97110239
76Abnormal delayed hypersensitivity skin test (HP:0002963)1.96824963
77Birth length less than 3rd percentile (HP:0003561)1.94070291
78Long palpebral fissure (HP:0000637)1.93338725
79Onycholysis (HP:0001806)1.92428632
80Erythema (HP:0010783)1.92403508
81Tetraparesis (HP:0002273)1.91766152
82Abnormality of reticulocytes (HP:0004312)1.90714313
83Impulsivity (HP:0100710)1.90646223
84Abnormal foot bone ossification (HP:0010675)1.90074284
85Cerebral hypomyelination (HP:0006808)1.89462818
86Abnormality of small intestinal villus morphology (HP:0011472)1.89152033
87Villous atrophy (HP:0011473)1.89152033
88Death in infancy (HP:0001522)1.87926338
89Hypokalemic alkalosis (HP:0001949)1.85223590
90Cortical dysplasia (HP:0002539)1.83402085
91Progressive neurologic deterioration (HP:0002344)1.83246191
92Hypokinesia (HP:0002375)1.81857502
93Abnormality of the thoracic spine (HP:0100711)1.80295272
94Abnormality of fatty-acid metabolism (HP:0004359)1.80185953
95Thoracolumbar scoliosis (HP:0002944)1.79589282
96Deep palmar crease (HP:0006191)1.78751036
97Death in childhood (HP:0003819)1.78672224
98Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77864979
99Thoracic kyphosis (HP:0002942)1.73864470
100Unsteady gait (HP:0002317)1.73821827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.24121009
2CDK194.66737246
3EIF2AK33.92993973
4KSR23.34643364
5TAF13.20171661
6ACVR1B3.16317355
7CDC72.99978277
8TAOK22.86231319
9BRAF2.70317097
10ARAF2.65634131
11SCYL22.49980059
12TESK22.21922062
13NME22.14771104
14TTK2.08813747
15BUB12.02912571
16ITK1.93533523
17ERN11.90394492
18MAP3K91.77593320
19IRAK31.76672771
20RAF11.68920756
21STK161.55204005
22PNCK1.52338091
23CDK31.48235640
24MAP3K21.42786422
25WEE11.39919644
26MAP3K81.32974848
27BRSK11.31812387
28KSR11.26026872
29RPS6KB21.23483419
30WNK41.23448335
31CDK81.21446554
32MAP3K11.15530400
33MAP3K101.07716814
34EEF2K1.07337608
35MAP3K131.06877488
36MATK1.06175283
37MAPK70.90744986
38STK100.90661038
39NME10.90000640
40PBK0.88363164
41STK390.86467520
42JAK20.78484298
43PLK40.77906726
44RPS6KB10.75742696
45PLK10.74440280
46ATR0.74298029
47CDK70.73693823
48MOS0.72242118
49CDK11A0.70288115
50PIM10.67303627
51AURKA0.65649054
52PAK20.64770142
53CHEK10.62974378
54AKT20.62138608
55CHEK20.59470178
56CSNK2A10.59023535
57CDK140.58214082
58INSRR0.55049453
59RPS6KC10.54197866
60RPS6KL10.54197866
61MAP3K120.50260273
62LRRK20.48834438
63ICK0.47868523
64BCKDK0.47448843
65NEK10.46846594
66STK240.46615585
67MARK30.46319396
68SRPK10.46265574
69RPS6KA60.45933200
70IRAK20.45139464
71KIT0.43478298
72PASK0.43079820
73MAP3K110.42410277
74NTRK30.42070810
75CDK150.41486452
76PAK10.39823950
77GRK60.39183239
78BMPR1B0.38853391
79AURKB0.38547495
80IRAK40.37697003
81CDK180.34764742
82CSF1R0.34753604
83DYRK1B0.34743671
84DAPK20.33082980
85CCNB10.32400451
86MAPK120.30815957
87CSNK2A20.30737347
88CSNK1G20.30491080
89NEK20.29887940
90ATM0.29762050
91PRKCI0.28972667
92CDK20.27996475
93CDK120.26448463
94CDK10.26339483
95RPS6KA10.25785833
96MAP2K10.25480696
97CLK10.24095552
98ALK0.23279881
99NEK60.21854838
100TRIM280.21095886

Predicted pathways (KEGG)

RankGene SetZ-score
1N-Glycan biosynthesis_Homo sapiens_hsa005104.43559350
2Ribosome_Homo sapiens_hsa030104.16038708
3DNA replication_Homo sapiens_hsa030303.79812351
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84973852
5Mismatch repair_Homo sapiens_hsa034302.63746854
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.59766835
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.56974519
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.56778315
9Proteasome_Homo sapiens_hsa030502.38692890
10RNA transport_Homo sapiens_hsa030132.28140502
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26357306
12Base excision repair_Homo sapiens_hsa034102.15434542
13One carbon pool by folate_Homo sapiens_hsa006702.06550171
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.04222527
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01943820
16Protein export_Homo sapiens_hsa030601.95138316
17mRNA surveillance pathway_Homo sapiens_hsa030151.95078025
18Dorso-ventral axis formation_Homo sapiens_hsa043201.89148078
19Cell cycle_Homo sapiens_hsa041101.82692452
20Bladder cancer_Homo sapiens_hsa052191.67730148
21Oxidative phosphorylation_Homo sapiens_hsa001901.57684238
22Fatty acid elongation_Homo sapiens_hsa000621.55779522
23Basal transcription factors_Homo sapiens_hsa030221.52868086
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46895871
25Collecting duct acid secretion_Homo sapiens_hsa049661.45104361
26Non-homologous end-joining_Homo sapiens_hsa034501.44954256
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39849095
28Acute myeloid leukemia_Homo sapiens_hsa052211.39152243
29Nucleotide excision repair_Homo sapiens_hsa034201.29746720
30Vibrio cholerae infection_Homo sapiens_hsa051101.29597657
31Homologous recombination_Homo sapiens_hsa034401.27125875
32Pyrimidine metabolism_Homo sapiens_hsa002401.25532856
33Lysosome_Homo sapiens_hsa041421.25273095
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20885095
35Parkinsons disease_Homo sapiens_hsa050121.13388029
36Prion diseases_Homo sapiens_hsa050201.13151716
37RNA polymerase_Homo sapiens_hsa030201.06365787
38Folate biosynthesis_Homo sapiens_hsa007901.05967801
39Spliceosome_Homo sapiens_hsa030401.05705790
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03898501
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00369664
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00128270
43Chronic myeloid leukemia_Homo sapiens_hsa052200.97356623
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94977133
45RNA degradation_Homo sapiens_hsa030180.87833364
46Non-small cell lung cancer_Homo sapiens_hsa052230.87374968
47Synaptic vesicle cycle_Homo sapiens_hsa047210.85345200
48Rheumatoid arthritis_Homo sapiens_hsa053230.85338840
49Other glycan degradation_Homo sapiens_hsa005110.84815111
50Alzheimers disease_Homo sapiens_hsa050100.82024087
51Huntingtons disease_Homo sapiens_hsa050160.75536977
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74162805
53Fanconi anemia pathway_Homo sapiens_hsa034600.73923773
54Sulfur metabolism_Homo sapiens_hsa009200.72934580
55Purine metabolism_Homo sapiens_hsa002300.68076498
56Oocyte meiosis_Homo sapiens_hsa041140.67865912
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67208449
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66609379
59Viral myocarditis_Homo sapiens_hsa054160.63614353
60Allograft rejection_Homo sapiens_hsa053300.61314845
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61205207
62T cell receptor signaling pathway_Homo sapiens_hsa046600.59667010
63Autoimmune thyroid disease_Homo sapiens_hsa053200.58915048
64Hepatitis B_Homo sapiens_hsa051610.58254981
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57874187
66Pancreatic cancer_Homo sapiens_hsa052120.57822773
67p53 signaling pathway_Homo sapiens_hsa041150.56561958
68Prostate cancer_Homo sapiens_hsa052150.56061101
69Melanoma_Homo sapiens_hsa052180.54505848
70Herpes simplex infection_Homo sapiens_hsa051680.53815834
71Graft-versus-host disease_Homo sapiens_hsa053320.52974004
72Measles_Homo sapiens_hsa051620.48111081
73Sulfur relay system_Homo sapiens_hsa041220.47748041
74HTLV-I infection_Homo sapiens_hsa051660.47176017
75Glioma_Homo sapiens_hsa052140.46737176
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45906532
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44289406
78Epstein-Barr virus infection_Homo sapiens_hsa051690.41964413
79Thyroid cancer_Homo sapiens_hsa052160.40197849
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38999698
81Metabolic pathways_Homo sapiens_hsa011000.38493613
82Vitamin B6 metabolism_Homo sapiens_hsa007500.38138184
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38069054
84Influenza A_Homo sapiens_hsa051640.36576506
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33876159
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.32995356
87mTOR signaling pathway_Homo sapiens_hsa041500.31811696
88Viral carcinogenesis_Homo sapiens_hsa052030.31485361
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.30918997
90Endometrial cancer_Homo sapiens_hsa052130.30087517
91Type I diabetes mellitus_Homo sapiens_hsa049400.28786104
92Insulin signaling pathway_Homo sapiens_hsa049100.27064988
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26996318
94FoxO signaling pathway_Homo sapiens_hsa040680.26829719
95Apoptosis_Homo sapiens_hsa042100.26744859
96Primary immunodeficiency_Homo sapiens_hsa053400.25333837
97B cell receptor signaling pathway_Homo sapiens_hsa046620.23597996
98Carbon metabolism_Homo sapiens_hsa012000.21917110
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.19693641
100Selenocompound metabolism_Homo sapiens_hsa004500.19308242

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