TSPY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)7.31334923
2piRNA metabolic process (GO:0034587)7.13489650
3* mesoderm development (GO:0007498)6.26335219
4* mesenchyme development (GO:0060485)6.00109656
5sex differentiation (GO:0007548)5.79756485
6* gonadal mesoderm development (GO:0007506)46.1260251
7positive regulation of meiosis (GO:0045836)4.67374592
8ribosomal small subunit assembly (GO:0000028)4.60929641
9ncRNA 3-end processing (GO:0043628)4.60057825
10positive regulation of meiotic cell cycle (GO:0051446)4.54195804
11regulation of activation of Janus kinase activity (GO:0010533)4.10106925
12* nucleosome assembly (GO:0006334)4.02933529
13folic acid transport (GO:0015884)3.95638285
14male meiosis (GO:0007140)3.88681443
15synapsis (GO:0007129)3.86563220
16nucleotide transmembrane transport (GO:1901679)3.81869211
17male meiosis I (GO:0007141)3.76166537
18* protein-DNA complex assembly (GO:0065004)3.66428223
19positive regulation of translational initiation (GO:0045948)3.44421207
20gene silencing by RNA (GO:0031047)3.43613099
21regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.38371451
22meiosis I (GO:0007127)3.38131255
23negative regulation of meiosis (GO:0045835)3.34626901
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30700866
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30700866
26* nucleosome organization (GO:0034728)3.26548049
27N-acetylneuraminate metabolic process (GO:0006054)3.24982104
28DNA catabolic process, exonucleolytic (GO:0000738)3.13588549
29oogenesis (GO:0048477)3.07150840
30ribosomal small subunit biogenesis (GO:0042274)3.06435411
31* protein-DNA complex subunit organization (GO:0071824)3.05781596
32regulation of meiosis (GO:0040020)3.02071070
33chromosome organization involved in meiosis (GO:0070192)2.96487448
34meiotic chromosome segregation (GO:0045132)2.95785863
35germ cell migration (GO:0008354)2.93699392
36meiotic nuclear division (GO:0007126)2.87179962
37lymphangiogenesis (GO:0001946)2.81980902
38ear development (GO:0043583)2.81301227
39nucleotide transport (GO:0006862)2.81071438
40synaptonemal complex assembly (GO:0007130)2.76239390
41one-carbon compound transport (GO:0019755)2.76071492
42CENP-A containing nucleosome assembly (GO:0034080)2.72066508
43regulation of sister chromatid cohesion (GO:0007063)2.69541461
44negative regulation of gene silencing (GO:0060969)2.69247376
45proteasome assembly (GO:0043248)2.68844359
46DNA double-strand break processing (GO:0000729)2.68609715
47mitotic chromosome condensation (GO:0007076)2.63300501
48DNA methylation involved in gamete generation (GO:0043046)2.63179557
49chromatin remodeling at centromere (GO:0031055)2.61761487
50regulation of meiotic cell cycle (GO:0051445)2.59394540
51viral transcription (GO:0019083)2.57332514
52synaptonemal complex organization (GO:0070193)2.54841772
53translational termination (GO:0006415)2.54161474
54meiotic cell cycle (GO:0051321)2.51186432
55regulation of fibroblast apoptotic process (GO:2000269)2.46368299
56mitotic sister chromatid cohesion (GO:0007064)2.45699675
57meiotic cell cycle process (GO:1903046)2.43761923
58resolution of meiotic recombination intermediates (GO:0000712)2.38390282
59positive regulation of viral genome replication (GO:0045070)2.35575092
60sister chromatid cohesion (GO:0007062)2.33845836
61fat-soluble vitamin biosynthetic process (GO:0042362)2.32281934
62female gamete generation (GO:0007292)2.32012020
63formation of translation preinitiation complex (GO:0001731)2.31926676
64translational elongation (GO:0006414)2.30446331
65histone exchange (GO:0043486)2.29215193
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.25847376
67G2 DNA damage checkpoint (GO:0031572)2.22999819
68cotranslational protein targeting to membrane (GO:0006613)2.20057841
69establishment of integrated proviral latency (GO:0075713)2.18303757
70positive regulation of alpha-beta T cell proliferation (GO:0046641)2.17892105
71blastocyst development (GO:0001824)2.17508790
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.14030985
73DNA replication-independent nucleosome assembly (GO:0006336)2.13037369
74DNA replication-independent nucleosome organization (GO:0034724)2.13037369
75protein targeting to ER (GO:0045047)2.12332884
76* male gamete generation (GO:0048232)2.11682254
77telomere maintenance via semi-conservative replication (GO:0032201)2.10894117
78protein localization to endoplasmic reticulum (GO:0070972)2.10444786
79* spermatogenesis (GO:0007283)2.10420147
80viral life cycle (GO:0019058)2.09830685
81establishment of protein localization to endoplasmic reticulum (GO:0072599)2.07796109
82protein K6-linked ubiquitination (GO:0085020)2.06837642
83negative regulation of meiotic cell cycle (GO:0051447)2.05978910
84cellular response to interleukin-15 (GO:0071350)2.04754265
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.04347283
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.03972853
87histone mRNA metabolic process (GO:0008334)2.03896783
88pyrimidine ribonucleoside catabolic process (GO:0046133)2.03695759
89translational initiation (GO:0006413)2.03459610
90DNA-dependent DNA replication (GO:0006261)2.03038524
91response to UV-B (GO:0010224)2.02382322
92hepatocyte apoptotic process (GO:0097284)1.99645900
93RNA phosphodiester bond hydrolysis (GO:0090501)1.95832754
94regulation of regulatory T cell differentiation (GO:0045589)1.95640395
95N-terminal protein amino acid acetylation (GO:0006474)1.95520376
96* gamete generation (GO:0007276)1.94569511
97vitamin D metabolic process (GO:0042359)1.94132925
98protein-cofactor linkage (GO:0018065)1.92664921
99cellular protein complex disassembly (GO:0043624)1.89876995
100positive regulation of mitochondrial fission (GO:0090141)1.89398607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.36788907
2E2F7_22180533_ChIP-Seq_HELA_Human4.01824554
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.78558852
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.70634266
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.59218469
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42702271
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36023806
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.16454688
9ZNF274_21170338_ChIP-Seq_K562_Hela2.92850722
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75561341
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72696191
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68214845
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.67362217
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63299465
15VDR_23849224_ChIP-Seq_CD4+_Human2.58772209
16IGF1R_20145208_ChIP-Seq_DFB_Human2.58710581
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42129167
18DCP1A_22483619_ChIP-Seq_HELA_Human2.37327751
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.26536231
20FOXP3_21729870_ChIP-Seq_TREG_Human2.25715833
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.23122413
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21451944
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.13410816
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.11082549
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07307702
26ELK1_19687146_ChIP-ChIP_HELA_Human2.04091848
27TTF2_22483619_ChIP-Seq_HELA_Human2.02379160
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01090986
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00414627
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98665381
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97651673
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96582844
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.95897467
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91777352
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91777352
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91777352
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88967705
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79682842
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77563231
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77015845
41TAF15_26573619_Chip-Seq_HEK293_Human1.74599429
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.69512749
43GABP_19822575_ChIP-Seq_HepG2_Human1.69406745
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68549107
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67728558
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67180047
47TFEB_21752829_ChIP-Seq_HELA_Human1.64144844
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62993253
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62920818
50VDR_22108803_ChIP-Seq_LS180_Human1.55732127
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53758964
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49991270
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49769533
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44818027
55HTT_18923047_ChIP-ChIP_STHdh_Human1.38852553
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38687390
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30466106
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.29220795
59ZNF263_19887448_ChIP-Seq_K562_Human1.23632175
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21325709
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20519202
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.20491698
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16812150
64MYB_26560356_Chip-Seq_TH2_Human1.14087293
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11273414
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10474262
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05554607
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05165717
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04797319
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04689369
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02960266
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99704080
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99493059
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98964356
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98814140
76NANOG_16153702_ChIP-ChIP_HESCs_Human0.96634661
77GATA3_26560356_Chip-Seq_TH1_Human0.96606902
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95533402
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92901721
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.92894159
81ERG_20517297_ChIP-Seq_VCAP_Human0.90249695
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88934228
83TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86686562
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86360793
85MYC_18940864_ChIP-ChIP_HL60_Human0.84063530
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83971434
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83342697
88GATA3_21867929_ChIP-Seq_TH1_Mouse0.83161335
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.80483408
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.79485857
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79485857
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78060875
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.77667534
94XRN2_22483619_ChIP-Seq_HELA_Human0.77506249
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.77000810
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75426007
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74528457
98TP53_22573176_ChIP-Seq_HFKS_Human0.74207856
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73951807
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73144921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.98352049
2MP0003136_yellow_coat_color3.67909206
3MP0003806_abnormal_nucleotide_metabolis3.58309743
4MP0008877_abnormal_DNA_methylation3.49542172
5MP0003693_abnormal_embryo_hatching3.12377003
6MP0002163_abnormal_gland_morphology3.08820709
7MP0004147_increased_porphyrin_level3.04347617
8MP0000372_irregular_coat_pigmentation2.83573287
9MP0005174_abnormal_tail_pigmentation2.78857002
10MP0004957_abnormal_blastocyst_morpholog2.67400280
11MP0005671_abnormal_response_to2.67399013
12MP0005075_abnormal_melanosome_morpholog2.61219840
13MP0003303_peritoneal_inflammation2.42638183
14MP0005379_endocrine/exocrine_gland_phen2.32770681
15MP0010094_abnormal_chromosome_stability2.17660573
16MP0002210_abnormal_sex_determination2.10027539
17MP0001879_abnormal_lymphatic_vessel2.05949397
18MP0001929_abnormal_gametogenesis1.98553215
19MP0005451_abnormal_body_composition1.98310264
20MP0010307_abnormal_tumor_latency1.94504746
21MP0008057_abnormal_DNA_replication1.90795198
22MP0003646_muscle_fatigue1.86732021
23MP0005408_hypopigmentation1.85640241
24MP0005367_renal/urinary_system_phenotyp1.84837649
25MP0000516_abnormal_urinary_system1.84837649
26MP0001145_abnormal_male_reproductive1.74175103
27MP0002877_abnormal_melanocyte_morpholog1.72511361
28MP0009379_abnormal_foot_pigmentation1.70466011
29MP0008995_early_reproductive_senescence1.69966302
30MP0001177_atelectasis1.63300975
31MP0003786_premature_aging1.63010770
32MP0009333_abnormal_splenocyte_physiolog1.62490478
33MP0003183_abnormal_peptide_metabolism1.57281282
34MP0003763_abnormal_thymus_physiology1.55309416
35MP0000653_abnormal_sex_gland1.52410209
36MP0002796_impaired_skin_barrier1.48013235
37MP0008932_abnormal_embryonic_tissue1.46101982
38MP0001873_stomach_inflammation1.40334967
39MP0003077_abnormal_cell_cycle1.38828093
40MP0002837_dystrophic_cardiac_calcinosis1.38033404
41MP0003698_abnormal_male_reproductive1.35552915
42MP0005058_abnormal_lysosome_morphology1.32477619
43MP0003186_abnormal_redox_activity1.31944233
44MP0008058_abnormal_DNA_repair1.31224075
45MP0003252_abnormal_bile_duct1.27198971
46MP0002277_abnormal_respiratory_mucosa1.26633941
47MP0002095_abnormal_skin_pigmentation1.20932556
48MP0001853_heart_inflammation1.20657980
49MP0002160_abnormal_reproductive_system1.20184352
50MP0001188_hyperpigmentation1.16122566
51MP0000350_abnormal_cell_proliferation1.14775501
52MP0003718_maternal_effect1.13810917
53MP0004782_abnormal_surfactant_physiolog1.12956625
54MP0000371_diluted_coat_color1.12948923
55MP0001666_abnormal_nutrient_absorption1.08001446
56MP0003111_abnormal_nucleus_morphology1.07512438
57MP0005670_abnormal_white_adipose1.05708533
58MP0004381_abnormal_hair_follicle1.05428713
59MP0003959_abnormal_lean_body1.05427625
60MP0000569_abnormal_digit_pigmentation1.02345835
61MP0000490_abnormal_crypts_of1.01073888
62MP0005171_absent_coat_pigmentation1.00626346
63MP0001730_embryonic_growth_arrest1.00169480
64MP0002009_preneoplasia0.99430658
65MP0002075_abnormal_coat/hair_pigmentati0.98313512
66MP0010155_abnormal_intestine_physiology0.97941499
67MP0005389_reproductive_system_phenotype0.97579893
68MP0008004_abnormal_stomach_pH0.97025705
69MP0005501_abnormal_skin_physiology0.95955499
70MP0001348_abnormal_lacrimal_gland0.94522543
71MP0005310_abnormal_salivary_gland0.92685716
72MP0003943_abnormal_hepatobiliary_system0.88266447
73MP0008007_abnormal_cellular_replicative0.87907656
74MP0004197_abnormal_fetal_growth/weight/0.86841790
75MP0002638_abnormal_pupillary_reflex0.86772007
76MP0000358_abnormal_cell_content/0.85376300
77MP0005410_abnormal_fertilization0.85342286
78MP0005395_other_phenotype0.80990810
79MP0001663_abnormal_digestive_system0.79776393
80MP0000313_abnormal_cell_death0.76674674
81MP0005464_abnormal_platelet_physiology0.76008792
82MP0003448_altered_tumor_morphology0.74624644
83MP0001697_abnormal_embryo_size0.72652085
84MP0002161_abnormal_fertility/fecundity0.71264550
85MP0002080_prenatal_lethality0.69913051
86MP0009840_abnormal_foam_cell0.69693537
87MP0000920_abnormal_myelination0.69562070
88MP0002398_abnormal_bone_marrow0.69505145
89MP0000343_altered_response_to0.69354051
90MP0000015_abnormal_ear_pigmentation0.68812678
91MP0001119_abnormal_female_reproductive0.68682257
92MP0001186_pigmentation_phenotype0.66693632
93MP0001800_abnormal_humoral_immune0.63672324
94MP0000462_abnormal_digestive_system0.61692863
95MP0003880_abnormal_central_pattern0.59185835
96MP0005381_digestive/alimentary_phenotyp0.58720959
97MP0004215_abnormal_myocardial_fiber0.58152734
98MP0009785_altered_susceptibility_to0.57987337
99MP0001919_abnormal_reproductive_system0.57788504
100MP0002148_abnormal_hypersensitivity_rea0.57715220

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the costochondral junction (HP:0000919)4.56979072
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.38982787
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.38982787
4Carpal bone hypoplasia (HP:0001498)4.08203883
5Reticulocytopenia (HP:0001896)3.59895605
6Chronic diarrhea (HP:0002028)3.57625053
7Microvesicular hepatic steatosis (HP:0001414)3.54127483
8Abnormality of the corticospinal tract (HP:0002492)3.43762496
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.34422469
10Type I transferrin isoform profile (HP:0003642)3.27458706
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27195048
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27195048
13Delayed epiphyseal ossification (HP:0002663)3.20606390
14Abnormality of the renal collecting system (HP:0004742)3.10067177
15Squamous cell carcinoma (HP:0002860)3.08229786
16Increased hepatocellular lipid droplets (HP:0006565)3.05756094
17Lipid accumulation in hepatocytes (HP:0006561)3.03763519
18Abnormal glycosylation (HP:0012345)3.03444540
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.03444540
20Abnormal protein N-linked glycosylation (HP:0012347)3.03444540
21Abnormal protein glycosylation (HP:0012346)3.03444540
22Abnormality of DNA repair (HP:0003254)2.97920553
23Abnormality of T cell number (HP:0011839)2.94843561
24Abnormality of T cell physiology (HP:0011840)2.92606046
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83945642
26Duplicated collecting system (HP:0000081)2.82166845
27Reduced antithrombin III activity (HP:0001976)2.78296853
28T lymphocytopenia (HP:0005403)2.78227356
29Abnormality of T cells (HP:0002843)2.78189818
30Chromsome breakage (HP:0040012)2.76016597
31Enlarged epiphyses (HP:0010580)2.73151237
32Hyperglycinuria (HP:0003108)2.62162242
33Increased CSF lactate (HP:0002490)2.59593690
34Patchy hypopigmentation of hair (HP:0011365)2.59341585
35Thin bony cortex (HP:0002753)2.52126800
36Metaphyseal irregularity (HP:0003025)2.49015172
37Premature skin wrinkling (HP:0100678)2.45767114
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.45119812
39Volvulus (HP:0002580)2.44311013
40Horizontal nystagmus (HP:0000666)2.42788378
41Osteomalacia (HP:0002749)2.42677477
42Scotoma (HP:0000575)2.40341676
43Azoospermia (HP:0000027)2.39587993
44IgG deficiency (HP:0004315)2.38970318
45Acute necrotizing encephalopathy (HP:0006965)2.37966622
46Abnormality of oral frenula (HP:0000190)2.37573129
47Cutaneous melanoma (HP:0012056)2.36468093
48Abnormal auditory evoked potentials (HP:0006958)2.36139755
49Dysphonia (HP:0001618)2.36062258
50Abnormal spermatogenesis (HP:0008669)2.34654339
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.34522060
52Exocrine pancreatic insufficiency (HP:0001738)2.31059924
53Recurrent cutaneous fungal infections (HP:0011370)2.28288384
54Chronic mucocutaneous candidiasis (HP:0002728)2.28288384
55J-shaped sella turcica (HP:0002680)2.25648980
56Mitochondrial inheritance (HP:0001427)2.24565605
57IgA deficiency (HP:0002720)2.21667913
58Hyperglycinemia (HP:0002154)2.16786248
59White forelock (HP:0002211)2.14746726
60Flat occiput (HP:0005469)2.11743791
61Abnormal mitochondria in muscle tissue (HP:0008316)2.09668422
62Acute encephalopathy (HP:0006846)2.08856792
63Ectopic kidney (HP:0000086)2.07629235
64Poikiloderma (HP:0001029)2.07530248
65IgM deficiency (HP:0002850)2.07114303
66Basal cell carcinoma (HP:0002671)2.06414114
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06266082
68Short tibia (HP:0005736)2.04604929
69Death in childhood (HP:0003819)2.03397502
70Hypercortisolism (HP:0001578)2.01222086
71Severe global developmental delay (HP:0011344)2.01219327
72Cerebral edema (HP:0002181)2.00691502
73Esophageal neoplasm (HP:0100751)2.00648547
74Neoplasm of head and neck (HP:0012288)2.00648547
75Vacuolated lymphocytes (HP:0001922)2.00542193
76Horseshoe kidney (HP:0000085)2.00267060
77Macrocytic anemia (HP:0001972)2.00112343
78Progressive inability to walk (HP:0002505)2.00048984
79Widely patent fontanelles and sutures (HP:0004492)1.99473282
80Progressive microcephaly (HP:0000253)1.94834410
81Retinal dysplasia (HP:0007973)1.94307317
82Septate vagina (HP:0001153)1.94146587
83Asplenia (HP:0001746)1.92784645
84Autoimmune hemolytic anemia (HP:0001890)1.89443233
85Abnormality of glycine metabolism (HP:0010895)1.88821998
86Abnormality of serine family amino acid metabolism (HP:0010894)1.88821998
87Progressive macrocephaly (HP:0004481)1.88167843
88Gonadal dysgenesis (HP:0000133)1.87732887
89Rimmed vacuoles (HP:0003805)1.86821831
90Micronodular cirrhosis (HP:0001413)1.84979482
91Deformed sella turcica (HP:0002681)1.84022676
92Hypoproteinemia (HP:0003075)1.83386244
93Abnormality of pyrimidine metabolism (HP:0004353)1.79179693
94Hyperlipoproteinemia (HP:0010980)1.78349953
95Beaking of vertebral bodies (HP:0004568)1.76486256
96Rickets (HP:0002748)1.76281552
97Paralysis (HP:0003470)1.74071565
98Testicular atrophy (HP:0000029)1.73462100
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.73025138
100Sparse eyelashes (HP:0000653)1.72429545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.89158104
2TXK5.74969004
3CDK195.08913401
4WNK42.81515764
5TTK2.78961157
6PLK42.72190789
7STK392.63812479
8PBK2.27689675
9PNCK2.15533859
10EIF2AK31.99659114
11ARAF1.91214667
12BCR1.82354480
13BRAF1.74693431
14KSR21.62752166
15WEE11.40917746
16ITK1.36490173
17BUB11.35744586
18NEK91.30312267
19MATK1.28606986
20SCYL21.15099697
21OXSR11.12271880
22NME11.01706710
23RAF10.98181829
24MAP3K20.95786343
25PIM10.93253245
26CDC70.92813833
27NTRK30.90661432
28CDK80.88501975
29PASK0.83560627
30EPHA40.83419885
31MAPK110.82985386
32TEC0.81935814
33ZAK0.81474317
34KSR10.81416116
35BRSK10.80208970
36TAF10.79863025
37PRPF4B0.78430147
38PLK10.76831144
39KIT0.76342705
40STK160.75153970
41DAPK20.74985508
42PRKCQ0.74453262
43MAP3K90.72155639
44CDK30.71106309
45STK100.69904757
46ATR0.68015385
47TAOK20.64364982
48CSNK1G20.62725775
49MAP3K80.62389685
50MARK30.59975226
51NME20.55339335
52BMPR1B0.54780172
53ADRBK20.54756888
54MAP3K140.54530983
55PHKG20.54289416
56PHKG10.54289416
57STK240.51469181
58ABL20.48350209
59CHEK10.48185049
60MAP3K10.47790841
61WNK10.47573684
62AURKA0.46825356
63NEK60.46454774
64CHEK20.46114188
65GRK70.44684605
66PIM20.43780915
67CDK70.42216199
68TYRO30.41139125
69TRIM280.40511648
70TIE10.35956489
71ATM0.35039179
72RPS6KB10.35034703
73CDK11A0.34975625
74MAP3K130.34911801
75CSNK2A10.34066369
76VRK20.33905716
77LYN0.33849998
78KDR0.33013263
79TGFBR10.31689142
80AURKB0.31385341
81JAK20.31148733
82CSNK2A20.28710204
83CSNK1G10.28428483
84BCKDK0.27806213
85MAP3K120.26481198
86RPS6KB20.25701614
87ERBB40.25564494
88CDK140.24515803
89GRK60.23552781
90VRK10.22371785
91INSRR0.22198664
92PRKCG0.21868152
93SYK0.21863627
94PLK20.21263393
95CSNK1G30.21160053
96LCK0.19008800
97STK38L0.18672738
98PRKACA0.16826880
99PRKCI0.16343046
100CDK10.16113526

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.87906568
2DNA replication_Homo sapiens_hsa030303.81525978
3Homologous recombination_Homo sapiens_hsa034403.21351580
4Mismatch repair_Homo sapiens_hsa034303.06046527
5N-Glycan biosynthesis_Homo sapiens_hsa005102.90043587
6Nucleotide excision repair_Homo sapiens_hsa034202.40934292
7Base excision repair_Homo sapiens_hsa034102.39883132
8Non-homologous end-joining_Homo sapiens_hsa034502.20211694
9Oxidative phosphorylation_Homo sapiens_hsa001902.19929810
10Dorso-ventral axis formation_Homo sapiens_hsa043202.19018773
11Autoimmune thyroid disease_Homo sapiens_hsa053202.18552952
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14737786
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12815292
14Rheumatoid arthritis_Homo sapiens_hsa053232.08022159
15p53 signaling pathway_Homo sapiens_hsa041152.03748802
16RNA transport_Homo sapiens_hsa030131.95014030
17Folate biosynthesis_Homo sapiens_hsa007901.94473959
18Fanconi anemia pathway_Homo sapiens_hsa034601.92195551
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.91733448
20Collecting duct acid secretion_Homo sapiens_hsa049661.90184058
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.76744001
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.72236755
23Basal transcription factors_Homo sapiens_hsa030221.70959998
24Cell cycle_Homo sapiens_hsa041101.70778402
25Protein export_Homo sapiens_hsa030601.67172844
26Proteasome_Homo sapiens_hsa030501.65713361
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60937860
28Primary immunodeficiency_Homo sapiens_hsa053401.59300628
29RNA degradation_Homo sapiens_hsa030181.48548983
30Allograft rejection_Homo sapiens_hsa053301.47806863
31Pyrimidine metabolism_Homo sapiens_hsa002401.47618511
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.42862704
33Graft-versus-host disease_Homo sapiens_hsa053321.40514472
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40232388
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39733648
36Steroid biosynthesis_Homo sapiens_hsa001001.27338805
37mRNA surveillance pathway_Homo sapiens_hsa030151.26718202
38Parkinsons disease_Homo sapiens_hsa050121.24644969
39One carbon pool by folate_Homo sapiens_hsa006701.22430693
40Antigen processing and presentation_Homo sapiens_hsa046121.12121213
41Type I diabetes mellitus_Homo sapiens_hsa049401.08891706
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04616713
43Alzheimers disease_Homo sapiens_hsa050100.97674993
44Regulation of autophagy_Homo sapiens_hsa041400.97115061
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95847020
46Vibrio cholerae infection_Homo sapiens_hsa051100.95263868
47RNA polymerase_Homo sapiens_hsa030200.94335989
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91276971
49Huntingtons disease_Homo sapiens_hsa050160.85813430
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.85651347
51T cell receptor signaling pathway_Homo sapiens_hsa046600.82255884
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80760870
53Viral myocarditis_Homo sapiens_hsa054160.78141265
54Hematopoietic cell lineage_Homo sapiens_hsa046400.76223179
55Bladder cancer_Homo sapiens_hsa052190.75026994
56Purine metabolism_Homo sapiens_hsa002300.72800896
57Lysosome_Homo sapiens_hsa041420.71561063
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71441877
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70179685
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68985367
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66045565
62Fatty acid elongation_Homo sapiens_hsa000620.65503677
63Ether lipid metabolism_Homo sapiens_hsa005650.65371971
64Synaptic vesicle cycle_Homo sapiens_hsa047210.64480805
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63714881
66ABC transporters_Homo sapiens_hsa020100.61989576
67Sulfur metabolism_Homo sapiens_hsa009200.61942775
68Oocyte meiosis_Homo sapiens_hsa041140.60411574
69Fat digestion and absorption_Homo sapiens_hsa049750.57549911
70Metabolic pathways_Homo sapiens_hsa011000.53909242
71HTLV-I infection_Homo sapiens_hsa051660.52443751
72Endocytosis_Homo sapiens_hsa041440.49491186
73Spliceosome_Homo sapiens_hsa030400.49192482
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47785486
75Shigellosis_Homo sapiens_hsa051310.46760457
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45271008
77TGF-beta signaling pathway_Homo sapiens_hsa043500.41738592
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39703182
79Cardiac muscle contraction_Homo sapiens_hsa042600.39283612
80Linoleic acid metabolism_Homo sapiens_hsa005910.35619366
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35210222
82Selenocompound metabolism_Homo sapiens_hsa004500.34565253
83Measles_Homo sapiens_hsa051620.33975089
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31609479
85Pancreatic secretion_Homo sapiens_hsa049720.30751062
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.28936701
87Sulfur relay system_Homo sapiens_hsa041220.28406702
88Arachidonic acid metabolism_Homo sapiens_hsa005900.27277880
89Prion diseases_Homo sapiens_hsa050200.26808241
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26763823
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25542185
92beta-Alanine metabolism_Homo sapiens_hsa004100.24494941
93Glycerolipid metabolism_Homo sapiens_hsa005610.23306801
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22799793
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.21646891
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20381850
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19665781
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19246128
99Viral carcinogenesis_Homo sapiens_hsa052030.16137798
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15959963

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