TSPO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.83455810
2protoporphyrinogen IX biosynthetic process (GO:0006782)9.46590828
3heme biosynthetic process (GO:0006783)8.52253801
4porphyrin-containing compound biosynthetic process (GO:0006779)7.44759315
5heme metabolic process (GO:0042168)6.87456546
6antibacterial humoral response (GO:0019731)6.71087789
7tetrapyrrole biosynthetic process (GO:0033014)6.67644198
8innate immune response in mucosa (GO:0002227)6.56529765
9killing of cells of other organism (GO:0031640)6.34210540
10disruption of cells of other organism (GO:0044364)6.34210540
11antimicrobial humoral response (GO:0019730)6.18906071
12defense response to fungus (GO:0050832)6.13818821
13porphyrin-containing compound metabolic process (GO:0006778)6.06200414
14regulation of response to osmotic stress (GO:0047484)6.00425074
15ribosomal small subunit assembly (GO:0000028)5.98019089
16erythrocyte maturation (GO:0043249)5.97044751
17DNA deamination (GO:0045006)5.68349090
18viral transcription (GO:0019083)5.44348000
19mucosal immune response (GO:0002385)5.36295594
20translational termination (GO:0006415)5.23416963
21glycine transport (GO:0015816)5.13108418
22organ or tissue specific immune response (GO:0002251)5.02061999
23negative regulation of erythrocyte differentiation (GO:0045647)4.87588171
24translational elongation (GO:0006414)4.71632488
25telomere maintenance via semi-conservative replication (GO:0032201)4.69507856
26one-carbon compound transport (GO:0019755)4.68465970
27erythrocyte development (GO:0048821)4.62063268
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.61270251
29DNA replication initiation (GO:0006270)4.55057873
30cotranslational protein targeting to membrane (GO:0006613)4.50377700
31protein targeting to ER (GO:0045047)4.49061443
32DNA strand elongation involved in DNA replication (GO:0006271)4.44749151
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.34346983
34response to fungus (GO:0009620)4.32425896
35ribosomal small subunit biogenesis (GO:0042274)4.30758471
36hydrogen peroxide catabolic process (GO:0042744)4.28114814
37protein localization to endoplasmic reticulum (GO:0070972)4.28052243
38establishment of protein localization to endoplasmic reticulum (GO:0072599)4.27672946
39DNA strand elongation (GO:0022616)4.22227692
40response to insecticide (GO:0017085)4.19563844
41folic acid-containing compound biosynthetic process (GO:0009396)4.18716944
42pigment biosynthetic process (GO:0046148)4.14341361
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11283020
443-UTR-mediated mRNA stabilization (GO:0070935)4.10513669
45megakaryocyte development (GO:0035855)4.08855472
46cellular protein complex disassembly (GO:0043624)4.08079433
47translational initiation (GO:0006413)4.06866079
48intracellular estrogen receptor signaling pathway (GO:0030520)4.03111496
49viral life cycle (GO:0019058)4.02154428
50response to arsenic-containing substance (GO:0046685)4.01219120
51detection of bacterium (GO:0016045)3.99403902
52tetrapyrrole metabolic process (GO:0033013)3.99246124
53very-low-density lipoprotein particle assembly (GO:0034379)3.99068672
54maturation of SSU-rRNA (GO:0030490)3.96811993
55DNA replication checkpoint (GO:0000076)3.94566994
56proteasome assembly (GO:0043248)3.90565396
57telomere maintenance via recombination (GO:0000722)3.81849225
58detection of other organism (GO:0098543)3.74713873
59definitive hemopoiesis (GO:0060216)3.74638978
60positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.74594465
61protein autoprocessing (GO:0016540)3.72946841
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70636554
63disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.69749163
64killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.69749163
65actin filament capping (GO:0051693)3.68191326
66bicarbonate transport (GO:0015701)3.67812494
67erythrocyte differentiation (GO:0030218)3.67396093
68CENP-A containing nucleosome assembly (GO:0034080)3.61914551
69regulation of natural killer cell differentiation (GO:0032823)3.61659491
70gas transport (GO:0015669)3.59536575
71protein complex disassembly (GO:0043241)3.58270898
72pseudouridine synthesis (GO:0001522)3.56738747
73iron ion import (GO:0097286)3.56654488
74pigment metabolic process (GO:0042440)3.51221051
75ribosomal large subunit biogenesis (GO:0042273)3.49985213
762-deoxyribonucleotide biosynthetic process (GO:0009265)3.49439490
77deoxyribose phosphate biosynthetic process (GO:0046385)3.49439490
78chromatin remodeling at centromere (GO:0031055)3.44732460
79translation (GO:0006412)3.43531452
80deoxyribonucleotide biosynthetic process (GO:0009263)3.43118826
81embryonic hemopoiesis (GO:0035162)3.40108342
82mitotic recombination (GO:0006312)3.40042656
83macromolecular complex disassembly (GO:0032984)3.37925721
84ribonucleoprotein complex biogenesis (GO:0022613)3.37635421
85DNA unwinding involved in DNA replication (GO:0006268)3.37340533
86platelet formation (GO:0030220)3.36160473
87telomere maintenance via telomere lengthening (GO:0010833)3.32964240
88cellular response to virus (GO:0098586)3.32365905
89cell killing (GO:0001906)3.31535182
90response to lead ion (GO:0010288)3.28245593
91DNA replication-independent nucleosome organization (GO:0034724)3.25701433
92DNA replication-independent nucleosome assembly (GO:0006336)3.25701433
93regulation of RNA export from nucleus (GO:0046831)3.25288603
94protein targeting to plasma membrane (GO:0072661)3.25161821
95response to peptidoglycan (GO:0032494)3.24845825
96pteridine-containing compound biosynthetic process (GO:0042559)3.24602146
97modulation by virus of host process (GO:0019054)3.24330236
98formation of translation preinitiation complex (GO:0001731)3.22547346
99positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.20180005
100negative regulation of viral entry into host cell (GO:0046597)3.20056510
101nuclear-transcribed mRNA catabolic process (GO:0000956)3.19976076
102positive regulation of fibroblast migration (GO:0010763)3.19467154
103kinetochore organization (GO:0051383)3.19239210
104spliceosomal snRNP assembly (GO:0000387)3.11033611
105positive regulation of erythrocyte differentiation (GO:0045648)3.09880746
106rRNA processing (GO:0006364)3.09526449
107rRNA modification (GO:0000154)3.08500937
108DNA replication-dependent nucleosome assembly (GO:0006335)3.07887746
109DNA replication-dependent nucleosome organization (GO:0034723)3.07887746
110kinetochore assembly (GO:0051382)3.07352239
111iron-sulfur cluster assembly (GO:0016226)3.07225556
112metallo-sulfur cluster assembly (GO:0031163)3.07225556
113defense response to Gram-positive bacterium (GO:0050830)3.06379981
114nucleotide-excision repair, DNA gap filling (GO:0006297)3.03969649
115viral mRNA export from host cell nucleus (GO:0046784)3.03586305
116mRNA catabolic process (GO:0006402)3.02978340
117ribosome biogenesis (GO:0042254)3.01099945
118rRNA metabolic process (GO:0016072)3.00370445
119histone mRNA metabolic process (GO:0008334)2.99626554
120RNA catabolic process (GO:0006401)2.99062336
121protein targeting to membrane (GO:0006612)2.97613640
122cellular response to arsenic-containing substance (GO:0071243)2.96690607
123protein localization to chromosome, centromeric region (GO:0071459)2.95453107
124tRNA methylation (GO:0030488)2.94362797
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93978063
126negative regulation of RNA splicing (GO:0033119)2.93868414
127hemoglobin metabolic process (GO:0020027)2.93273846
128regulation of histone H3-K9 methylation (GO:0051570)2.93014675
129granulocyte activation (GO:0036230)2.92934012
130folic acid metabolic process (GO:0046655)2.91873977
131regulation of erythrocyte differentiation (GO:0045646)2.90363621
132imidazole-containing compound metabolic process (GO:0052803)2.89855865
133plasma lipoprotein particle assembly (GO:0034377)2.89244405
134oxidative phosphorylation (GO:0006119)2.88839944
135negative regulation of execution phase of apoptosis (GO:1900118)2.88482567
136positive regulation of granulocyte differentiation (GO:0030854)2.88284935
137translesion synthesis (GO:0019985)2.87298470
138spliceosomal complex assembly (GO:0000245)2.86731588
139neutrophil activation (GO:0042119)2.85811352
140negative regulation of actin filament depolymerization (GO:0030835)2.84948135
141myeloid cell development (GO:0061515)2.83553666
142response to methylmercury (GO:0051597)2.80660468
143cellular component biogenesis (GO:0044085)2.80594939
144regulation of platelet aggregation (GO:0090330)2.79328163
145hepatocyte apoptotic process (GO:0097284)2.77851905
146regulation of granulocyte differentiation (GO:0030852)2.76933277
147regulation of mitochondrial translation (GO:0070129)2.76218540
148modulation by symbiont of host cellular process (GO:0044068)2.75297743
149maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74491018
150exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74224824
151neutrophil activation involved in immune response (GO:0002283)2.73633411
152negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73251756
153granulocyte differentiation (GO:0030851)2.72909392
154regulation of nucleobase-containing compound transport (GO:0032239)2.69590545
155regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.68891809
156hydrogen peroxide metabolic process (GO:0042743)2.66624406
157positive regulation of megakaryocyte differentiation (GO:0045654)2.64099679
158N-terminal protein amino acid acetylation (GO:0006474)2.62768520
159hemopoiesis (GO:0030097)2.58513153
160superoxide anion generation (GO:0042554)2.58080959
161protein-lipid complex assembly (GO:0065005)2.52574424
162cellular response to dexamethasone stimulus (GO:0071549)2.52363293
163negative regulation of growth of symbiont in host (GO:0044130)2.50042849
164negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.50042849
165modulation of growth of symbiont involved in interaction with host (GO:0044144)2.50042849
166regulation of growth of symbiont in host (GO:0044126)2.50042849
167regulation of interleukin-8 biosynthetic process (GO:0045414)2.49951839
168regulation of viral entry into host cell (GO:0046596)2.48714302
169leukocyte migration involved in inflammatory response (GO:0002523)2.46396982
170modification of morphology or physiology of other organism (GO:0035821)2.45895334
171positive thymic T cell selection (GO:0045059)2.45479755
172DNA topological change (GO:0006265)2.45435269
173positive regulation of gluconeogenesis (GO:0045722)2.43992346
174cellular extravasation (GO:0045123)2.42735733
175response to mercury ion (GO:0046689)2.42119792
176iron ion homeostasis (GO:0055072)2.41441948
177oxygen transport (GO:0015671)13.1102544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.56406866
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.47608936
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01180989
4GATA2_19941826_ChIP-Seq_K562_Human3.82533244
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27383709
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96768445
7GATA1_22025678_ChIP-Seq_K562_Human2.95323870
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.85248913
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81858104
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81810075
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.75856641
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.72809972
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.69967372
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63170293
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56994962
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50857075
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45309119
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44243114
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43496643
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42091593
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33623948
22TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.32216347
23VDR_23849224_ChIP-Seq_CD4+_Human2.29641629
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28427322
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23851667
26SCL_19346495_ChIP-Seq_HPC-7_Human2.20525844
27TCF7_22412390_ChIP-Seq_EML_Mouse2.20194371
28XRN2_22483619_ChIP-Seq_HELA_Human2.12600495
29GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.06952328
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06640367
31VDR_24763502_ChIP-Seq_THP-1_Human2.03908350
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96745611
33GATA1_22383799_ChIP-Seq_G1ME_Mouse1.95068496
34NCOR1_26117541_ChIP-Seq_K562_Human1.94944998
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94687745
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.93684624
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92320238
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91613136
39FOXP3_21729870_ChIP-Seq_TREG_Human1.91102002
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91091261
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.89604230
42DCP1A_22483619_ChIP-Seq_HELA_Human1.89340770
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88242665
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84365012
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.82960244
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82452165
47GABP_19822575_ChIP-Seq_HepG2_Human1.82110734
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81446619
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.79885213
50MAF_26560356_Chip-Seq_TH1_Human1.79202457
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77206637
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77017543
53KDM2B_26808549_Chip-Seq_DND41_Human1.75290073
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71395410
55TTF2_22483619_ChIP-Seq_HELA_Human1.70329732
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68198792
57UTX_26944678_Chip-Seq_JUKART_Human1.64856597
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62922319
59AR_21909140_ChIP-Seq_LNCAP_Human1.60079713
60GATA1_19941826_ChIP-Seq_K562_Human1.59708715
61MYC_22102868_ChIP-Seq_BL_Human1.59517436
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56477203
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55613453
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.53495680
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51952973
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.49532281
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.49411178
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49010712
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48114012
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47452935
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46498186
72ELK1_19687146_ChIP-ChIP_HELA_Human1.44741745
73CIITA_25753668_ChIP-Seq_RAJI_Human1.43717823
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43149519
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42909733
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42630687
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42287944
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42159019
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37321485
80VDR_21846776_ChIP-Seq_THP-1_Human1.36393146
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.35886231
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35350586
83SPI1_23127762_ChIP-Seq_K562_Human1.33827016
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33325917
85MYB_26560356_Chip-Seq_TH1_Human1.32488822
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30306292
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.29678489
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29570253
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.28730628
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28356456
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27829101
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23960414
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23852713
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23841611
95MYB_26560356_Chip-Seq_TH2_Human1.22939226
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22843567
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21625236
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21090199
99MAF_26560356_Chip-Seq_TH2_Human1.19922277
100BCOR_27268052_Chip-Seq_Bcells_Human1.19526822
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19192759
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17580568
103KDM5A_27292631_Chip-Seq_BREAST_Human1.16944402
104RXR_22158963_ChIP-Seq_LIVER_Mouse1.16110036
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14321741
106LXR_22292898_ChIP-Seq_THP-1_Human1.13811938
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13783160
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13121441
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12615992
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.12436728
111KDM2B_26808549_Chip-Seq_K562_Human1.12261730
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11751383
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10348398
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.09630274
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06881729
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05727865
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.05725116
118* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04296536
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04029092
120BCL6_27268052_Chip-Seq_Bcells_Human1.02321801
121MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01905078
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01293719
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00659620
124MYC_18940864_ChIP-ChIP_HL60_Human0.98541266
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98490404
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98266089
127SPI1_23547873_ChIP-Seq_NB4_Human0.98124880
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98109670
129P68_20966046_ChIP-Seq_HELA_Human0.97843874
130TFEB_21752829_ChIP-Seq_HELA_Human0.96799074
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95462920
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94604895
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93813671
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93609450
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93322092
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92756687
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92034857
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91700484
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91369578
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90417147
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89610221
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.89598048
143ZNF263_19887448_ChIP-Seq_K562_Human0.89486363
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.89431970
145STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89231010
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89061414
147IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88116594
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87594654
149ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87570277
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87315970
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86775240
152RUNX_20019798_ChIP-Seq_JUKART_Human0.86093422
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86041656
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85419787
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85320813
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84881824
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84677470
158LXR_22158963_ChIP-Seq_LIVER_Mouse0.84213492
159Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83791002
160PU_27001747_Chip-Seq_BMDM_Mouse0.83058104
161CTCF_21964334_Chip-Seq_Bcells_Human0.82053396
162ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81709697
163RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81212454
164GATA3_27048872_Chip-Seq_THYMUS_Human0.80321965
165PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78935927
166SPI1_20517297_ChIP-Seq_HL60_Human0.76468786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.08764847
2MP0004147_increased_porphyrin_level8.16392962
3MP0001545_abnormal_hematopoietic_system3.69477059
4MP0005397_hematopoietic_system_phenotyp3.69477059
5MP0006054_spinal_hemorrhage3.65811357
6MP0003111_abnormal_nucleus_morphology3.54488325
7MP0003693_abnormal_embryo_hatching3.31306278
8MP0003303_peritoneal_inflammation3.21683045
9MP0010094_abnormal_chromosome_stability3.08510532
10MP0002396_abnormal_hematopoietic_system2.97369562
11MP0003806_abnormal_nucleotide_metabolis2.84846268
12MP0008057_abnormal_DNA_replication2.77000472
13MP0004957_abnormal_blastocyst_morpholog2.73702997
14MP0003077_abnormal_cell_cycle2.61435978
15MP0009278_abnormal_bone_marrow2.51035983
16MP0002132_abnormal_respiratory_system2.41143897
17MP0008058_abnormal_DNA_repair2.25709134
18MP0003186_abnormal_redox_activity2.14078108
19MP0006036_abnormal_mitochondrial_physio2.03086815
20MP0000490_abnormal_crypts_of2.00432332
21MP0005636_abnormal_mineral_homeostasis1.91705137
22MP0009333_abnormal_splenocyte_physiolog1.81462833
23MP0003172_abnormal_lysosome_physiology1.75208580
24MP0009379_abnormal_foot_pigmentation1.74896061
25MP0008007_abnormal_cellular_replicative1.67171033
26MP0003191_abnormal_cellular_cholesterol1.61109554
27MP0004215_abnormal_myocardial_fiber1.56963373
28MP0002398_abnormal_bone_marrow1.56762707
29MP0005076_abnormal_cell_differentiation1.43318420
30MP0003045_fibrosis1.40716756
31MP0008995_early_reproductive_senescence1.38971116
32MP0005174_abnormal_tail_pigmentation1.37950735
33MP0003436_decreased_susceptibility_to1.35497788
34MP0005451_abnormal_body_composition1.32594725
35MP0008775_abnormal_heart_ventricle1.31995309
36MP0000689_abnormal_spleen_morphology1.31810127
37MP0002722_abnormal_immune_system1.30740620
38MP0003724_increased_susceptibility_to1.27011419
39MP0000313_abnormal_cell_death1.24509222
40MP0008932_abnormal_embryonic_tissue1.23518577
41MP0002429_abnormal_blood_cell1.20801230
42MP0002419_abnormal_innate_immunity1.20705392
43MP0002102_abnormal_ear_morphology1.20625810
44MP0000350_abnormal_cell_proliferation1.20241758
45MP0005075_abnormal_melanosome_morpholog1.17640783
46MP0008872_abnormal_physiological_respon1.17309228
47MP0003878_abnormal_ear_physiology1.15777367
48MP0005377_hearing/vestibular/ear_phenot1.15777367
49MP0002019_abnormal_tumor_incidence1.10475760
50MP0005671_abnormal_response_to1.10044249
51MP0000685_abnormal_immune_system1.08277478
52MP0004808_abnormal_hematopoietic_stem1.07780411
53MP0002139_abnormal_hepatobiliary_system1.05576443
54MP0004185_abnormal_adipocyte_glucose1.05465819
55MP0002095_abnormal_skin_pigmentation1.04546260
56MP0003786_premature_aging1.03502800
57MP0006035_abnormal_mitochondrial_morpho1.03367504
58MP0005083_abnormal_biliary_tract1.01313045
59MP0000358_abnormal_cell_content/0.93406554
60MP0002009_preneoplasia0.91622318
61MP0005000_abnormal_immune_tolerance0.91598629
62MP0005387_immune_system_phenotype0.91520432
63MP0001790_abnormal_immune_system0.91520432
64MP0000703_abnormal_thymus_morphology0.91153369
65MP0001730_embryonic_growth_arrest0.88767214
66MP0005464_abnormal_platelet_physiology0.88544491
67MP0001764_abnormal_homeostasis0.87532759
68MP0001853_heart_inflammation0.86332818
69MP0001529_abnormal_vocalization0.84647434
70MP0002080_prenatal_lethality0.83689080
71MP0003763_abnormal_thymus_physiology0.82682584
72MP0000716_abnormal_immune_system0.82116524
73MP0009765_abnormal_xenobiotic_induced0.80354416
74MP0008789_abnormal_olfactory_epithelium0.79149353
75MP0001835_abnormal_antigen_presentation0.78572355
76MP0002138_abnormal_hepatobiliary_system0.76301621
77MP0006292_abnormal_olfactory_placode0.74835606
78MP0009931_abnormal_skin_appearance0.74381550
79MP0010307_abnormal_tumor_latency0.72572568
80MP0003567_abnormal_fetal_cardiomyocyte0.70101097
81MP0004947_skin_inflammation0.69075882
82MP0002822_catalepsy0.68344525
83MP0005058_abnormal_lysosome_morphology0.67361695
84MP0005266_abnormal_metabolism0.67351444
85MP0004130_abnormal_muscle_cell0.66631266
86MP0009764_decreased_sensitivity_to0.66614430
87MP0002166_altered_tumor_susceptibility0.66198125
88MP0008469_abnormal_protein_level0.65758509
89MP0001663_abnormal_digestive_system0.64872841
90MP0003566_abnormal_cell_adhesion0.64054685
91MP0003453_abnormal_keratinocyte_physiol0.63676655
92MP0009840_abnormal_foam_cell0.63532368
93MP0003718_maternal_effect0.62591443
94MP0001845_abnormal_inflammatory_respons0.61651190
95MP0005310_abnormal_salivary_gland0.61169564
96MP0003300_gastrointestinal_ulcer0.60737952
97MP0000609_abnormal_liver_physiology0.60076084
98MP0009643_abnormal_urine_homeostasis0.59543499
99MP0005584_abnormal_enzyme/coenzyme_acti0.59322231
100MP0005025_abnormal_response_to0.58966254
101MP0001697_abnormal_embryo_size0.58825787
102MP0000598_abnormal_liver_morphology0.58657030
103MP0008770_decreased_survivor_rate0.58648053
104MP0005319_abnormal_enzyme/_coenzyme0.58586627
105MP0009785_altered_susceptibility_to0.57562829
106MP0005501_abnormal_skin_physiology0.57256226
107MP0002420_abnormal_adaptive_immunity0.56768146
108MP0005499_abnormal_olfactory_system0.56652374
109MP0005394_taste/olfaction_phenotype0.56652374
110MP0005376_homeostasis/metabolism_phenot0.56577960
111MP0002405_respiratory_system_inflammati0.55855934
112MP0001819_abnormal_immune_cell0.55572450
113MP0000749_muscle_degeneration0.55500614
114MP0001800_abnormal_humoral_immune0.54958130
115MP0003221_abnormal_cardiomyocyte_apopto0.53667154
116MP0005384_cellular_phenotype0.52623473
117MP0000858_altered_metastatic_potential0.52258232
118MP0008260_abnormal_autophagy0.51608360
119MP0002086_abnormal_extraembryonic_tissu0.51360521
120MP0002653_abnormal_ependyma_morphology0.49567599
121MP0010155_abnormal_intestine_physiology0.49298184
122MP0001873_stomach_inflammation0.49285107
123MP0001851_eye_inflammation0.49224879
124MP0009763_increased_sensitivity_to0.49082147
125MP0003123_paternal_imprinting0.47477311
126MP0002452_abnormal_antigen_presenting0.47167487
127MP0001243_abnormal_dermal_layer0.46517698
128MP0003866_abnormal_defecation0.45786249
129MP0002723_abnormal_immune_serum0.45502930
130MP0006082_CNS_inflammation0.44567408
131MP0003879_abnormal_hair_cell0.44558590
132MP0001915_intracranial_hemorrhage0.44460153
133MP0002006_tumorigenesis0.43426653
134MP0001293_anophthalmia0.43365089
135MP0000465_gastrointestinal_hemorrhage0.43327202
136MP0002136_abnormal_kidney_physiology0.43195784
137MP0000015_abnormal_ear_pigmentation0.42871705
138MP0005621_abnormal_cell_physiology0.42412740

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.79801858
2Abnormality of cells of the erythroid lineage (HP:0012130)8.48668913
3Poikilocytosis (HP:0004447)7.31293117
4Abnormal hemoglobin (HP:0011902)6.45431501
5Acanthocytosis (HP:0001927)6.29105704
6Reticulocytosis (HP:0001923)5.83431839
7Abnormality of reticulocytes (HP:0004312)5.27180397
8Birth length less than 3rd percentile (HP:0003561)4.52519439
9Pallor (HP:0000980)4.52506314
10Reticulocytopenia (HP:0001896)4.27177832
11Toxemia of pregnancy (HP:0100603)4.25673327
12Hyperbilirubinemia (HP:0002904)4.20927582
13Petechiae (HP:0000967)3.83385662
14Aplastic anemia (HP:0001915)3.82396486
15Diaphragmatic weakness (HP:0009113)3.77914370
16Macrocytic anemia (HP:0001972)3.74850510
17Increased serum ferritin (HP:0003281)3.74651422
18Prolonged bleeding time (HP:0003010)3.34633282
19Abnormality of iron homeostasis (HP:0011031)3.24417970
20Abnormality of the fingertips (HP:0001211)3.16870074
21Paralysis (HP:0003470)3.10907826
22Cholelithiasis (HP:0001081)3.09471551
23Hypochromic microcytic anemia (HP:0004840)3.05183391
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04044800
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04044800
26Oral leukoplakia (HP:0002745)3.01044465
27Cutaneous photosensitivity (HP:0000992)3.00914042
28Abnormality of transition element cation homeostasis (HP:0011030)2.99323824
29Short middle phalanx of the 5th finger (HP:0004220)2.92264779
30Microcytic anemia (HP:0001935)2.88827429
31Gastrointestinal infarctions (HP:0005244)2.86444025
32Insomnia (HP:0100785)2.75166442
33Hepatocellular necrosis (HP:0001404)2.73581743
34Abnormal gallbladder morphology (HP:0012437)2.70872240
35Mitochondrial inheritance (HP:0001427)2.67411007
36Polycythemia (HP:0001901)2.64647191
37Acute necrotizing encephalopathy (HP:0006965)2.53082912
38Abnormal mitochondria in muscle tissue (HP:0008316)2.51747558
39Abnormal gallbladder physiology (HP:0012438)2.49465950
40Cholecystitis (HP:0001082)2.49465950
41Hepatocellular carcinoma (HP:0001402)2.48328386
42Increased CSF lactate (HP:0002490)2.47461240
43Type I transferrin isoform profile (HP:0003642)2.46762712
44Hepatic necrosis (HP:0002605)2.42724626
45Increased serum lactate (HP:0002151)2.41496478
46Reduced antithrombin III activity (HP:0001976)2.40703011
47Increased hepatocellular lipid droplets (HP:0006565)2.37535753
48Osteomyelitis (HP:0002754)2.37257606
49Epistaxis (HP:0000421)2.36613944
50Hypertensive crisis (HP:0100735)2.36447814
51Lipid accumulation in hepatocytes (HP:0006561)2.32898208
523-Methylglutaconic aciduria (HP:0003535)2.28144029
53Nausea (HP:0002018)2.27586629
54Increased intramyocellular lipid droplets (HP:0012240)2.25547030
55Hypochromic anemia (HP:0001931)2.24983765
56Autoimmune thrombocytopenia (HP:0001973)2.24968192
57Ileus (HP:0002595)2.21412998
58Abnormality of sodium homeostasis (HP:0010931)2.15370375
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13709278
60Cerebral palsy (HP:0100021)2.13377138
61Urticaria (HP:0001025)2.11915384
62Exertional dyspnea (HP:0002875)2.10776847
63Myelodysplasia (HP:0002863)2.08692263
64Breast hypoplasia (HP:0003187)2.04995250
65Increased muscle lipid content (HP:0009058)2.04658842
66Acute encephalopathy (HP:0006846)2.03782203
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03211531
68Osteomalacia (HP:0002749)2.02479681
69Abnormality of the heme biosynthetic pathway (HP:0010472)13.5661327
70Hypoplasia of the pons (HP:0012110)1.99554796
71Lactic acidosis (HP:0003128)1.98754176
72Abnormality of the pons (HP:0007361)1.96761019
73Pancytopenia (HP:0001876)1.96615851
74Thrombophlebitis (HP:0004418)1.94846635
75Cerebellar dysplasia (HP:0007033)1.94825522
76Chromsome breakage (HP:0040012)1.94035434
77Recurrent abscess formation (HP:0002722)1.94013154
78Hyponatremia (HP:0002902)1.93706760
79Pendular nystagmus (HP:0012043)1.92805543
80Eczematoid dermatitis (HP:0000976)1.92653274
81Gastrointestinal dysmotility (HP:0002579)1.92424066
82Microvesicular hepatic steatosis (HP:0001414)1.91835118
83Brushfield spots (HP:0001088)1.91285448
84Abnormal spermatogenesis (HP:0008669)1.90994839
85Cerebral hypomyelination (HP:0006808)1.90654480
86Delusions (HP:0000746)1.90379822
87Abnormality of the preputium (HP:0100587)1.89175227
88Severe visual impairment (HP:0001141)1.88855493
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88272829
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.87647526
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87253450
92Tongue fasciculations (HP:0001308)1.86768534
93Progressive macrocephaly (HP:0004481)1.85354256
94Chronic otitis media (HP:0000389)1.84926687
95Paresthesia (HP:0003401)1.84734344
96Recurrent bacterial skin infections (HP:0005406)1.83452642
97Abnormal protein glycosylation (HP:0012346)1.83320530
98Abnormal glycosylation (HP:0012345)1.83320530
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83320530
100Abnormal protein N-linked glycosylation (HP:0012347)1.83320530
101Abnormality of the gallbladder (HP:0005264)1.82458224
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80504091
103Rough bone trabeculation (HP:0100670)1.79184735
104Respiratory difficulties (HP:0002880)1.77053637
105Gingival bleeding (HP:0000225)1.77008025
106Respiratory failure (HP:0002878)1.75291366
107Small intestinal stenosis (HP:0012848)1.75016049
108Duodenal stenosis (HP:0100867)1.75016049
109Inflammation of the large intestine (HP:0002037)1.72850594
110Microretrognathia (HP:0000308)1.71333182
111Impaired platelet aggregation (HP:0003540)1.71313159
112Abnormal platelet function (HP:0011869)1.71313159
113Abnormal platelet volume (HP:0011876)1.71095545
114Obstructive lung disease (HP:0006536)1.70835625
115Chronic obstructive pulmonary disease (HP:0006510)1.70835625
116Pustule (HP:0200039)1.70049127
117Abnormality of chromosome stability (HP:0003220)1.70029090
118Autoimmune hemolytic anemia (HP:0001890)1.68410168
119Cellulitis (HP:0100658)1.68212351
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67884407
121Hypoparathyroidism (HP:0000829)1.67869005
122Gastrointestinal inflammation (HP:0004386)1.66967883
123Abnormality of alanine metabolism (HP:0010916)1.66711115
124Hyperalaninemia (HP:0003348)1.66711115
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66711115
126Neoplasm of the liver (HP:0002896)1.65786964
127Azoospermia (HP:0000027)1.64752393
128Renal Fanconi syndrome (HP:0001994)1.64498009
129Recurrent gram-negative bacterial infections (HP:0005420)1.64398359
130Hypopigmented skin patches (HP:0001053)1.63961169
131Nonimmune hydrops fetalis (HP:0001790)1.61258405
132Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60675742
133Rectal prolapse (HP:0002035)1.60652022
134Slow saccadic eye movements (HP:0000514)1.60214568
135Increased mean platelet volume (HP:0011877)1.53765471
136Anorexia (HP:0002039)1.52819203
137Fatigue (HP:0012378)1.51865934
138Hypertriglyceridemia (HP:0002155)1.51836079
139Skin rash (HP:0000988)1.51208670
140Abnormality of macrophages (HP:0004311)1.50511056
141Splenomegaly (HP:0001744)1.49749301
142Prenatal maternal abnormality (HP:0002686)1.48518846
143Spontaneous hematomas (HP:0007420)1.48439772
144Recurrent viral infections (HP:0004429)1.45538529
145Gingivitis (HP:0000230)1.44967280
146Abnormality of nail color (HP:0100643)1.39440087
147Nasal polyposis (HP:0100582)1.36833381
148Orthostatic hypotension (HP:0001278)1.36515905
149Metaphyseal cupping (HP:0003021)1.35834823
150Autoamputation (HP:0001218)1.35186482
151Renal tubular acidosis (HP:0001947)1.35100980
152Recurrent skin infections (HP:0001581)1.33764566
153Meningitis (HP:0001287)1.33406101
154Leukocytosis (HP:0001974)1.33139927
155Visual hallucinations (HP:0002367)1.32788481
156Peripheral hypomyelination (HP:0007182)1.30553304
157Hepatosplenomegaly (HP:0001433)1.29079370
158Anhidrosis (HP:0000970)1.26240388
159Vasculitis (HP:0002633)1.26174078
160Abnormality of T cell physiology (HP:0011840)1.25619401
161Systemic lupus erythematosus (HP:0002725)1.25045638
162Abnormality of the thoracic spine (HP:0100711)1.24983834
163Keratoconjunctivitis sicca (HP:0001097)1.24738626
164Arthralgia (HP:0002829)1.24653830
165Abnormality of binocular vision (HP:0011514)1.24399544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.95519587
2EIF2AK14.86235793
3NME24.71897713
4TAOK13.72066733
5TAOK23.58660980
6TLK13.34980017
7STK163.32781949
8WEE13.27745628
9VRK13.19936612
10CDC73.08403582
11DYRK32.73046451
12MAP3K32.62619473
13BUB12.44117876
14SCYL22.29672711
15PIM22.24766315
16CDK192.03387062
17NEK21.98484019
18BMX1.96479803
19BRSK21.86117470
20BRSK11.82658616
21RIPK41.80657360
22WNK11.79975550
23TNIK1.68109800
24ACVR1B1.67140216
25MAPKAPK51.66658638
26EEF2K1.55550268
27SRPK11.54128591
28CAMK1D1.52647994
29STK41.47948259
30CDK121.44140153
31ZAK1.34654797
32ERN11.33967800
33MARK31.33693668
34TNK21.33590373
35HIPK21.30934820
36AURKB1.29945829
37NME11.27218481
38ATR1.24665662
39KDR1.24069634
40PLK11.22866111
41CDK71.22151617
42PBK1.22035494
43RPS6KB21.21510382
44STK101.19723046
45MAP3K111.18356899
46SGK31.18330045
47MAP3K11.18269477
48MAP3K61.13000466
49EIF2AK31.12778664
50CDK81.11337829
51TRIB31.09565566
52TRPM71.08757236
53AURKA1.07968957
54SGK21.06083887
55NEK11.04844587
56CDK41.03651311
57FGR1.02832285
58TTK1.01904804
59RPS6KL11.01656985
60RPS6KC11.01656985
61PTK2B1.01504615
62MAPKAPK31.01352725
63PIM10.99475001
64IKBKE0.97543289
65FLT30.94499591
66MAP3K80.93786885
67LRRK20.92544030
68MAP3K100.90164024
69ICK0.90062415
70JAK20.89650934
71MUSK0.89463353
72KIT0.89195507
73CHEK20.87854109
74MAP2K10.87470604
75SMG10.87462730
76RPS6KA40.85620278
77RPS6KA60.85609489
78PRKAA20.84654914
79MAP4K10.83717637
80MAP2K30.83600220
81MAPK110.83386883
82KSR20.82488794
83RPS6KA50.81835309
84KSR10.81270591
85STK110.80716172
86TBK10.80715607
87CCNB10.78578596
88TAOK30.78366530
89DYRK1B0.77335993
90FES0.76912517
91TGFBR20.76665666
92CAMK1G0.73921739
93TSSK60.73522201
94BRD40.72708999
95SGK10.71057001
96LYN0.69768437
97CHEK10.69725453
98ABL20.69695377
99EIF2AK20.69040838
100SYK0.67852953
101TYK20.66105454
102IRAK40.65859620
103CSNK2A20.65810462
104ATM0.65803731
105MATK0.65228677
106SGK2230.65172336
107SGK4940.65172336
108SIK20.64229218
109RAF10.63751701
110MAP2K20.63193351
111CSNK2A10.61713904
112MKNK10.59724198
113GRK70.59331696
114RPS6KA20.59097815
115TEC0.56908796
116HCK0.56055684
117IKBKB0.55874245
118MAP2K40.55872517
119TGFBR10.54187890
120SIK30.54132939
121DAPK10.52534443
122MARK20.52006892
123SIK10.51206471
124PASK0.50134146
125YES10.43901829
126MKNK20.42465485
127AKT10.42043334
128CAMK40.41712824
129CDK20.40992773
130BTK0.40671743
131MAP2K70.40510093
132MTOR0.40455374
133GRK60.40244871
134CHUK0.40034027
135BRAF0.38909075
136MAP3K50.38460176
137PTK60.36624725
138CLK10.36298619
139PLK40.36064154
140JAK30.35287425
141ZAP700.33083169
142CDK60.32621409
143DYRK20.32528408
144IRAK30.32320083
145PDPK10.32114084
146GRK50.31449480
147MAPKAPK20.31243735
148ITK0.31058898
149GRK10.30962320
150PRKACG0.30698996
151PLK30.30696622
152MAPK30.30486536
153PRKD20.29133026
154CDK10.28906859
155CDK11A0.27675154
156MAPK40.27181378
157MAPK120.26777699
158BLK0.26755975
159TESK20.25761665
160RPS6KA10.25616542
161PRKCQ0.24601437

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.11597175
2DNA replication_Homo sapiens_hsa030305.08441316
3Ribosome_Homo sapiens_hsa030104.93057294
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.73450800
5Mismatch repair_Homo sapiens_hsa034303.54537475
6African trypanosomiasis_Homo sapiens_hsa051433.13617009
7Proteasome_Homo sapiens_hsa030502.74087470
8RNA polymerase_Homo sapiens_hsa030202.70950112
9Spliceosome_Homo sapiens_hsa030402.66401870
10Pyrimidine metabolism_Homo sapiens_hsa002402.63931001
11Nucleotide excision repair_Homo sapiens_hsa034202.58356712
12Homologous recombination_Homo sapiens_hsa034402.56586250
13One carbon pool by folate_Homo sapiens_hsa006702.53894205
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47099923
15Systemic lupus erythematosus_Homo sapiens_hsa053222.40572399
16Base excision repair_Homo sapiens_hsa034102.38826726
17Cell cycle_Homo sapiens_hsa041102.13406992
18Sulfur relay system_Homo sapiens_hsa041222.09927565
19Nitrogen metabolism_Homo sapiens_hsa009102.06139856
20RNA transport_Homo sapiens_hsa030131.95390835
21Fanconi anemia pathway_Homo sapiens_hsa034601.92544300
22Parkinsons disease_Homo sapiens_hsa050121.88650953
23Asthma_Homo sapiens_hsa053101.86982267
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84632953
25Pancreatic cancer_Homo sapiens_hsa052121.84240166
26Folate biosynthesis_Homo sapiens_hsa007901.62004342
27Oxidative phosphorylation_Homo sapiens_hsa001901.61530478
28Collecting duct acid secretion_Homo sapiens_hsa049661.61447128
29Non-homologous end-joining_Homo sapiens_hsa034501.56079120
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.42724920
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42559699
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.41938364
33Caffeine metabolism_Homo sapiens_hsa002321.41167213
34RNA degradation_Homo sapiens_hsa030181.39288928
35Huntingtons disease_Homo sapiens_hsa050161.38526368
36Protein export_Homo sapiens_hsa030601.38132137
37p53 signaling pathway_Homo sapiens_hsa041151.37576068
38FoxO signaling pathway_Homo sapiens_hsa040681.37291461
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31914664
40Renal cell carcinoma_Homo sapiens_hsa052111.29942215
41B cell receptor signaling pathway_Homo sapiens_hsa046621.29589082
42Purine metabolism_Homo sapiens_hsa002301.29290834
43Basal transcription factors_Homo sapiens_hsa030221.29061360
44Osteoclast differentiation_Homo sapiens_hsa043801.26943968
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22638626
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21257932
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19319605
48Selenocompound metabolism_Homo sapiens_hsa004501.18767331
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.16298242
50Hematopoietic cell lineage_Homo sapiens_hsa046401.15436167
51Alcoholism_Homo sapiens_hsa050341.15037012
52Pentose phosphate pathway_Homo sapiens_hsa000301.13042674
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11509643
54mTOR signaling pathway_Homo sapiens_hsa041501.05490118
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05061278
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04997775
57HIF-1 signaling pathway_Homo sapiens_hsa040661.01665026
58Alzheimers disease_Homo sapiens_hsa050101.01083557
59Hepatitis C_Homo sapiens_hsa051601.00830589
60Prostate cancer_Homo sapiens_hsa052150.99469376
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98694933
62Endometrial cancer_Homo sapiens_hsa052130.97268089
63Herpes simplex infection_Homo sapiens_hsa051680.95190649
64Tuberculosis_Homo sapiens_hsa051520.90744550
65AMPK signaling pathway_Homo sapiens_hsa041520.87602756
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84079744
67T cell receptor signaling pathway_Homo sapiens_hsa046600.80781055
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80509951
69Prolactin signaling pathway_Homo sapiens_hsa049170.80134419
70Vitamin B6 metabolism_Homo sapiens_hsa007500.79990621
71Viral carcinogenesis_Homo sapiens_hsa052030.79650348
72ABC transporters_Homo sapiens_hsa020100.79589902
73Glutathione metabolism_Homo sapiens_hsa004800.79502183
74Type II diabetes mellitus_Homo sapiens_hsa049300.77585658
75Inositol phosphate metabolism_Homo sapiens_hsa005620.77361107
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.77293680
77Staphylococcus aureus infection_Homo sapiens_hsa051500.77286256
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77195188
79Glioma_Homo sapiens_hsa052140.76891671
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.75294609
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73971614
82TNF signaling pathway_Homo sapiens_hsa046680.71860953
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71185431
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.70272845
85Choline metabolism in cancer_Homo sapiens_hsa052310.70208066
86Toxoplasmosis_Homo sapiens_hsa051450.68047791
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67848573
88Other glycan degradation_Homo sapiens_hsa005110.67458391
89Insulin resistance_Homo sapiens_hsa049310.65713488
90VEGF signaling pathway_Homo sapiens_hsa043700.65350060
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64772516
92mRNA surveillance pathway_Homo sapiens_hsa030150.64722809
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64094898
94Epstein-Barr virus infection_Homo sapiens_hsa051690.63561050
95Fructose and mannose metabolism_Homo sapiens_hsa000510.62469523
96N-Glycan biosynthesis_Homo sapiens_hsa005100.62448683
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.61879596
98MicroRNAs in cancer_Homo sapiens_hsa052060.61162948
99Notch signaling pathway_Homo sapiens_hsa043300.60820860
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59242352
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58492386
102Platelet activation_Homo sapiens_hsa046110.57790019
103Metabolic pathways_Homo sapiens_hsa011000.57422771
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57259648
105Chemokine signaling pathway_Homo sapiens_hsa040620.57011159
106Antigen processing and presentation_Homo sapiens_hsa046120.52857295
107Insulin signaling pathway_Homo sapiens_hsa049100.52433093
108Biosynthesis of amino acids_Homo sapiens_hsa012300.52420403
109Fatty acid biosynthesis_Homo sapiens_hsa000610.52315121
110Carbon metabolism_Homo sapiens_hsa012000.48424585
111Pyruvate metabolism_Homo sapiens_hsa006200.43133444
112Measles_Homo sapiens_hsa051620.42552795
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39427877
114Apoptosis_Homo sapiens_hsa042100.38538536
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.38456370
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37244713
117Complement and coagulation cascades_Homo sapiens_hsa046100.37168254
118Melanoma_Homo sapiens_hsa052180.36516687
119Small cell lung cancer_Homo sapiens_hsa052220.36125617
120Oocyte meiosis_Homo sapiens_hsa041140.35864411
121Legionellosis_Homo sapiens_hsa051340.35347172
122Cardiac muscle contraction_Homo sapiens_hsa042600.33770203
123Glycerolipid metabolism_Homo sapiens_hsa005610.32012909
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31871631
125Hepatitis B_Homo sapiens_hsa051610.31006163
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30992318
127Bile secretion_Homo sapiens_hsa049760.30744787
128Phagosome_Homo sapiens_hsa041450.30645035
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30637081
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29265602
131Primary immunodeficiency_Homo sapiens_hsa053400.29258624
132GnRH signaling pathway_Homo sapiens_hsa049120.28333923
133Bladder cancer_Homo sapiens_hsa052190.28315090
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27804401
135Lysine degradation_Homo sapiens_hsa003100.25140215
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25105580
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24797806
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.24159220
139Lysosome_Homo sapiens_hsa041420.22547105
140Thyroid cancer_Homo sapiens_hsa052160.21583711
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19869246
142Malaria_Homo sapiens_hsa051440.19826409
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19588794
144beta-Alanine metabolism_Homo sapiens_hsa004100.18003758
145Arginine and proline metabolism_Homo sapiens_hsa003300.17606034
146Chronic myeloid leukemia_Homo sapiens_hsa052200.16023804
147HTLV-I infection_Homo sapiens_hsa051660.15543298
148Linoleic acid metabolism_Homo sapiens_hsa005910.15298696
149Peroxisome_Homo sapiens_hsa041460.15155360
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14342033
151Acute myeloid leukemia_Homo sapiens_hsa052210.14238297
152Galactose metabolism_Homo sapiens_hsa000520.12386774
153Influenza A_Homo sapiens_hsa051640.10729881
154Non-small cell lung cancer_Homo sapiens_hsa052230.05572111
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05190358
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.04746610
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.03710973
158Leishmaniasis_Homo sapiens_hsa051400.03657860
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.02958441
160Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.02611368
161Jak-STAT signaling pathway_Homo sapiens_hsa046300.02272767
162Arachidonic acid metabolism_Homo sapiens_hsa005900.01515039
163Fatty acid degradation_Homo sapiens_hsa000710.00941921
164Regulation of autophagy_Homo sapiens_hsa04140-0.0118526

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