TSPAN32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.39746193
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.05193586
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.81307591
4negative regulation of cell killing (GO:0031342)5.81307591
5viral transcription (GO:0019083)5.14503903
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.02368652
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.02368652
8neutrophil activation involved in immune response (GO:0002283)4.93142624
9translational termination (GO:0006415)4.90070845
10DNA deamination (GO:0045006)4.83456631
11positive regulation of gamma-delta T cell activation (GO:0046645)4.73059975
12antigen processing and presentation via MHC class Ib (GO:0002475)4.71402779
13response to peptidoglycan (GO:0032494)4.58943895
14negative thymic T cell selection (GO:0045060)4.43397362
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37701269
16antigen processing and presentation of endogenous antigen (GO:0019883)4.35882881
17translational elongation (GO:0006414)4.34143676
18positive thymic T cell selection (GO:0045059)4.33693679
19negative T cell selection (GO:0043383)4.32546017
20ribosomal small subunit biogenesis (GO:0042274)4.30383808
21cotranslational protein targeting to membrane (GO:0006613)4.27345720
22protein targeting to ER (GO:0045047)4.24385361
23detection of bacterium (GO:0016045)4.17318398
24response to interferon-beta (GO:0035456)4.13994826
25detection of other organism (GO:0098543)4.09110771
26response to muramyl dipeptide (GO:0032495)4.08309925
27protein localization to endoplasmic reticulum (GO:0070972)4.06546100
28definitive hemopoiesis (GO:0060216)4.06068260
29establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03688880
30cellular extravasation (GO:0045123)4.03277332
31maturation of SSU-rRNA (GO:0030490)4.02280069
32regulation of mast cell degranulation (GO:0043304)4.01563278
33modulation by symbiont of host immune response (GO:0052553)3.94595140
34positive regulation by symbiont of host defense response (GO:0052509)3.94595140
35modulation by symbiont of host defense response (GO:0052031)3.94595140
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94595140
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94595140
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.94595140
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91553162
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.91123584
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87534438
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.80744560
43platelet dense granule organization (GO:0060155)3.77548423
44negative regulation of T cell mediated immunity (GO:0002710)3.77438914
45viral life cycle (GO:0019058)3.74899643
46positive regulation of B cell differentiation (GO:0045579)3.69056757
47regulation of mast cell activation involved in immune response (GO:0033006)3.68915276
48positive T cell selection (GO:0043368)3.68667386
49cellular protein complex disassembly (GO:0043624)3.66751059
50neutrophil activation (GO:0042119)3.66462510
51telomere maintenance via semi-conservative replication (GO:0032201)3.62613950
52regulation of gamma-delta T cell differentiation (GO:0045586)3.60813115
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.58786214
54negative regulation of erythrocyte differentiation (GO:0045647)3.58189076
55negative regulation of leukocyte mediated immunity (GO:0002704)3.56231872
56translational initiation (GO:0006413)3.48869184
57T cell selection (GO:0045058)3.47909685
58thymic T cell selection (GO:0045061)3.44495634
59positive regulation of mast cell activation (GO:0033005)3.44104579
60regulation of mast cell activation (GO:0033003)3.43723169
61regulation of leukocyte degranulation (GO:0043300)3.42612235
62mast cell activation (GO:0045576)3.38468957
63myeloid cell activation involved in immune response (GO:0002275)3.38061348
64negative regulation of interleukin-12 production (GO:0032695)3.33817317
65leukocyte degranulation (GO:0043299)3.33295433
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.32990419
67T cell migration (GO:0072678)3.31921119
68regulation of gamma-delta T cell activation (GO:0046643)3.28907796
69regulation of alpha-beta T cell proliferation (GO:0046640)3.28638167
70microglial cell activation (GO:0001774)3.26883631
71macrophage activation involved in immune response (GO:0002281)3.26336186
72DNA strand elongation (GO:0022616)3.26125074
73protein complex disassembly (GO:0043241)3.25555806
74granulocyte activation (GO:0036230)3.25472177
75cellular response to interleukin-15 (GO:0071350)3.24483776
76megakaryocyte development (GO:0035855)3.24199270
77T cell homeostasis (GO:0043029)3.24150626
78DNA strand elongation involved in DNA replication (GO:0006271)3.21861540
79regulation of regulatory T cell differentiation (GO:0045589)3.20656350
80telomere maintenance via recombination (GO:0000722)3.19022067
81response to interferon-alpha (GO:0035455)3.18748255
82negative regulation of innate immune response (GO:0045824)3.18642828
83activated T cell proliferation (GO:0050798)3.17240728
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16989123
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15168000
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.14608494
87positive regulation of mast cell degranulation (GO:0043306)3.14608494
88regulation of B cell differentiation (GO:0045577)3.14206854
89response to host immune response (GO:0052572)3.13255767
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13255767
91regulation of granulocyte differentiation (GO:0030852)3.12910038
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10951099
93Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10412987
94regulation of antigen processing and presentation (GO:0002577)3.09030617
95thrombin receptor signaling pathway (GO:0070493)3.07745691
96regulation of natural killer cell mediated immunity (GO:0002715)3.06673782
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.06673782
98mature B cell differentiation involved in immune response (GO:0002313)3.06620442
99detection of external biotic stimulus (GO:0098581)3.05465405
100macromolecular complex disassembly (GO:0032984)3.04659701
101polyketide metabolic process (GO:0030638)3.03510362
102doxorubicin metabolic process (GO:0044598)3.03510362
103daunorubicin metabolic process (GO:0044597)3.03510362
104respiratory burst (GO:0045730)3.02699973
105regulation of B cell receptor signaling pathway (GO:0050855)3.02396168
106nuclear-transcribed mRNA catabolic process (GO:0000956)3.00569484
107positive regulation of antigen processing and presentation (GO:0002579)2.99609213
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95898693
109tolerance induction (GO:0002507)2.95676284
110negative regulation of phagocytosis (GO:0050765)2.94036684
111leukocyte migration involved in inflammatory response (GO:0002523)2.91611338
112positive regulation of granulocyte differentiation (GO:0030854)2.90451939
113mRNA catabolic process (GO:0006402)2.89833983
114cellular response to type I interferon (GO:0071357)2.89275652
115type I interferon signaling pathway (GO:0060337)2.89275652
116response to type I interferon (GO:0034340)2.88585012
117endosome to melanosome transport (GO:0035646)2.86095728
118endosome to pigment granule transport (GO:0043485)2.86095728
119lymphoid progenitor cell differentiation (GO:0002320)2.85944162
120negative regulation of interleukin-6 production (GO:0032715)2.85765303
121leukocyte aggregation (GO:0070486)2.85651850
122secretory granule organization (GO:0033363)2.84836514
123cellular response to interferon-beta (GO:0035458)2.82333404
124regulation of regulated secretory pathway (GO:1903305)2.82186651
125response to host defenses (GO:0052200)2.80795874
126response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80795874
127response to host (GO:0075136)2.80795874
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80297964
129regulation of tolerance induction (GO:0002643)2.80185461
130regulation of erythrocyte differentiation (GO:0045646)2.79214227
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79119102
132mitotic recombination (GO:0006312)2.78855362
133myeloid dendritic cell activation (GO:0001773)2.78824996
134telomere maintenance via telomere lengthening (GO:0010833)2.78700358
135antigen receptor-mediated signaling pathway (GO:0050851)2.78130463
136immunoglobulin mediated immune response (GO:0016064)2.77440844
137protein targeting to membrane (GO:0006612)2.76932360
138regulation of necroptotic process (GO:0060544)2.75719597
139RNA catabolic process (GO:0006401)2.75711026
140positive regulation of interleukin-17 production (GO:0032740)2.75233405
141ribosomal large subunit biogenesis (GO:0042273)2.74165033
142B cell receptor signaling pathway (GO:0050853)2.72631426
143lymph node development (GO:0048535)2.71235303
144regulation of T cell mediated cytotoxicity (GO:0001914)2.70490324
145positive regulation of T cell mediated cytotoxicity (GO:0001916)2.68614875
146DNA replication initiation (GO:0006270)2.68424280
147mast cell degranulation (GO:0043303)2.68092366
148mast cell activation involved in immune response (GO:0002279)2.68092366
149mucosal-associated lymphoid tissue development (GO:0048537)2.67819943
150Peyers patch development (GO:0048541)2.67819943
151ribonucleoprotein complex biogenesis (GO:0022613)2.67573005
152translation (GO:0006412)2.67401810
153regulation of T cell receptor signaling pathway (GO:0050856)2.67254783
154B cell mediated immunity (GO:0019724)2.66522550
155purine-containing compound salvage (GO:0043101)2.64508734
156CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.64289298
157mature B cell differentiation (GO:0002335)2.63423966
158necroptotic process (GO:0070266)2.63035979
159positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60753349
160iron-sulfur cluster assembly (GO:0016226)2.58533029
161metallo-sulfur cluster assembly (GO:0031163)2.58533029
162leukocyte homeostasis (GO:0001776)2.54650594
163pseudouridine synthesis (GO:0001522)2.53959269
164L-fucose catabolic process (GO:0042355)2.53739732
165fucose catabolic process (GO:0019317)2.53739732
166L-fucose metabolic process (GO:0042354)2.53739732
167respiratory chain complex IV assembly (GO:0008535)2.53736286
168response to interleukin-15 (GO:0070672)2.53412476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.15660693
2SCL_19346495_ChIP-Seq_HPC-7_Human3.57561608
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35242099
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.29232144
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.17187680
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17161202
7* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.12267598
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09372395
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.85215031
10* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.77286102
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.70612804
12* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.69346141
13* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.67173454
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41595787
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39574441
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.32514024
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25928618
18MYC_22102868_ChIP-Seq_BL_Human2.24104265
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.21455534
20* SPI1_23547873_ChIP-Seq_NB4_Human2.20290584
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.19642037
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19619194
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14738855
24VDR_21846776_ChIP-Seq_THP-1_Human2.11900470
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11829523
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10878742
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.10761315
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10218433
29IRF8_21731497_ChIP-ChIP_J774_Mouse2.09839184
30VDR_23849224_ChIP-Seq_CD4+_Human2.09227564
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07760055
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07138163
33GATA1_22025678_ChIP-Seq_K562_Human2.05948129
34* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.05481126
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04586012
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96435155
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96215663
38FOXP3_21729870_ChIP-Seq_TREG_Human1.93853703
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92967154
40* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91257026
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.90915813
42MYB_26560356_Chip-Seq_TH2_Human1.82185075
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78750377
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78081151
45CIITA_25753668_ChIP-Seq_RAJI_Human1.77536149
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74805948
47* RUNX1_22412390_ChIP-Seq_EML_Mouse1.74723904
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74162118
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.73940655
50* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73327281
51* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72793761
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.70289810
53* GATA1_19941826_ChIP-Seq_K562_Human1.70083596
54MAF_26560356_Chip-Seq_TH1_Human1.68228179
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66905982
56MYB_26560356_Chip-Seq_TH1_Human1.64164467
57* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.62460944
58XRN2_22483619_ChIP-Seq_HELA_Human1.62385107
59KDM2B_26808549_Chip-Seq_DND41_Human1.59787792
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57224866
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57054311
62VDR_24763502_ChIP-Seq_THP-1_Human1.57001596
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56929392
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56160341
65BCL6_27268052_Chip-Seq_Bcells_Human1.55493927
66UTX_26944678_Chip-Seq_JUKART_Human1.53249595
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52304294
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50931041
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50517659
70GATA3_26560356_Chip-Seq_TH2_Human1.47897323
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47234124
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47155104
73* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46771087
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45937382
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45849059
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.43121169
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43056982
78DCP1A_22483619_ChIP-Seq_HELA_Human1.39464629
79* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37766671
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.37590290
81GABP_19822575_ChIP-Seq_HepG2_Human1.37080425
82* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35428628
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35417828
84RUNX_20019798_ChIP-Seq_JUKART_Human1.34377760
85ELK1_19687146_ChIP-ChIP_HELA_Human1.32913065
86VDR_24787735_ChIP-Seq_THP-1_Human1.31987327
87BCOR_27268052_Chip-Seq_Bcells_Human1.30366361
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30173350
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.29066074
90* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28528450
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28509516
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28040561
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28035794
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25481754
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25182625
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25108156
97TTF2_22483619_ChIP-Seq_HELA_Human1.23882995
98* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23581538
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22697432
100TCF7_22412390_ChIP-Seq_EML_Mouse1.21856657
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21544820
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.20504434
103MAF_26560356_Chip-Seq_TH2_Human1.20345931
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19504913
105* GATA1_19941827_ChIP-Seq_MEL_Mouse1.17767347
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17492422
107THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17372215
108* LXR_22292898_ChIP-Seq_THP-1_Human1.15511348
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15435024
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14135452
111P300_27268052_Chip-Seq_Bcells_Human1.11465846
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.10161368
113* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09924874
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09794401
115* GATA2_19941826_ChIP-Seq_K562_Human1.09492116
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07826294
117SPI1_20517297_ChIP-Seq_HL60_Human1.07515282
118* NCOR1_26117541_ChIP-Seq_K562_Human1.07341315
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06238667
120E2F1_21310950_ChIP-Seq_MCF-7_Human1.06185678
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06081705
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05895043
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05143110
124GATA2_21666600_ChIP-Seq_HMVEC_Human1.04278732
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03603248
126MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03362598
127P68_20966046_ChIP-Seq_HELA_Human1.03270020
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01492991
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01456671
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00915033
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99454600
132SPI1_23127762_ChIP-Seq_K562_Human0.99027334
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98835655
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98198372
135GATA3_27048872_Chip-Seq_THYMUS_Human0.97685733
136* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93154585
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92855214
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92763804
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92301075
140* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91799117
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90446008
142PU_27001747_Chip-Seq_BMDM_Mouse0.85759325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.14864198
2MP0001835_abnormal_antigen_presentation3.91711237
3MP0005671_abnormal_response_to3.47585366
4MP0000685_abnormal_immune_system3.23854747
5MP0003763_abnormal_thymus_physiology2.99813675
6MP0009785_altered_susceptibility_to2.97764478
7MP0001545_abnormal_hematopoietic_system2.67543143
8MP0005397_hematopoietic_system_phenotyp2.67543143
9MP0004808_abnormal_hematopoietic_stem2.59924089
10MP0001800_abnormal_humoral_immune2.54837707
11MP0005464_abnormal_platelet_physiology2.51838307
12* MP0002398_abnormal_bone_marrow2.51055431
13MP0005075_abnormal_melanosome_morpholog2.47703914
14MP0003724_increased_susceptibility_to2.46794907
15MP0005025_abnormal_response_to2.46031795
16MP0005174_abnormal_tail_pigmentation2.42195087
17* MP0002420_abnormal_adaptive_immunity2.35965545
18MP0004147_increased_porphyrin_level2.32105954
19* MP0001819_abnormal_immune_cell2.31555906
20MP0005000_abnormal_immune_tolerance2.31329880
21MP0002452_abnormal_antigen_presenting2.31179543
22MP0002723_abnormal_immune_serum2.30441542
23MP0002166_altered_tumor_susceptibility2.25181922
24MP0000689_abnormal_spleen_morphology2.20017251
25MP0003436_decreased_susceptibility_to2.16419059
26MP0002148_abnormal_hypersensitivity_rea2.14900608
27* MP0000716_abnormal_immune_system2.11084986
28MP0005387_immune_system_phenotype2.10691237
29MP0001790_abnormal_immune_system2.10691237
30MP0003866_abnormal_defecation2.09923955
31MP0000490_abnormal_crypts_of2.09265466
32MP0002722_abnormal_immune_system2.08979395
33MP0000465_gastrointestinal_hemorrhage2.07261511
34MP0009333_abnormal_splenocyte_physiolog2.00792590
35MP0002419_abnormal_innate_immunity1.98835897
36MP0001853_heart_inflammation1.96937420
37MP0003656_abnormal_erythrocyte_physiolo1.94745759
38* MP0002429_abnormal_blood_cell1.94694788
39MP0008057_abnormal_DNA_replication1.87832515
40MP0010155_abnormal_intestine_physiology1.84660413
41MP0001873_stomach_inflammation1.83821812
42MP0002006_tumorigenesis1.76628892
43MP0010094_abnormal_chromosome_stability1.76234040
44MP0003693_abnormal_embryo_hatching1.74060671
45MP0002405_respiratory_system_inflammati1.71838580
46MP0002095_abnormal_skin_pigmentation1.70766530
47MP0000703_abnormal_thymus_morphology1.70507131
48MP0008058_abnormal_DNA_repair1.62598875
49MP0009379_abnormal_foot_pigmentation1.59457266
50MP0008007_abnormal_cellular_replicative1.48904319
51MP0001845_abnormal_inflammatory_respons1.44308752
52MP0002132_abnormal_respiratory_system1.42577314
53MP0003077_abnormal_cell_cycle1.39286604
54MP0008260_abnormal_autophagy1.35647326
55MP0006054_spinal_hemorrhage1.32446710
56MP0006082_CNS_inflammation1.27242723
57MP0006292_abnormal_olfactory_placode1.25664172
58MP0008469_abnormal_protein_level1.24309442
59MP0004957_abnormal_blastocyst_morpholog1.22415424
60MP0001986_abnormal_taste_sensitivity1.22278857
61MP0000015_abnormal_ear_pigmentation1.20928265
62MP0002019_abnormal_tumor_incidence1.20807727
63MP0008004_abnormal_stomach_pH1.19099650
64MP0003111_abnormal_nucleus_morphology1.18042609
65MP0004947_skin_inflammation1.13145888
66MP0003806_abnormal_nucleotide_metabolis1.12976579
67MP0003172_abnormal_lysosome_physiology1.02637816
68MP0009278_abnormal_bone_marrow1.02080078
69MP0002009_preneoplasia1.01009870
70MP0004510_myositis0.99124147
71MP0000858_altered_metastatic_potential0.96419723
72MP0003075_altered_response_to0.94734953
73MP0006036_abnormal_mitochondrial_physio0.94201392
74MP0003943_abnormal_hepatobiliary_system0.93774866
75MP0003828_pulmonary_edema0.93147966
76MP0002998_abnormal_bone_remodeling0.93040814
77MP0000313_abnormal_cell_death0.90971600
78MP0009764_decreased_sensitivity_to0.87346456
79MP0002933_joint_inflammation0.87268581
80MP0001533_abnormal_skeleton_physiology0.86757814
81MP0003786_premature_aging0.86656819
82MP0005166_decreased_susceptibility_to0.81918527
83MP0005390_skeleton_phenotype0.81633261
84MP0005310_abnormal_salivary_gland0.81632224
85MP0003186_abnormal_redox_activity0.80844802
86MP0003183_abnormal_peptide_metabolism0.76562365
87MP0004883_abnormal_blood_vessel0.76558680
88MP0009763_increased_sensitivity_to0.75928360
89MP0001663_abnormal_digestive_system0.74934752
90MP0000343_altered_response_to0.72518736
91MP0005083_abnormal_biliary_tract0.72505195
92MP0005451_abnormal_body_composition0.69858340
93MP0003303_peritoneal_inflammation0.68019837
94MP0003448_altered_tumor_morphology0.67064831
95MP0000371_diluted_coat_color0.65963945
96MP0000372_irregular_coat_pigmentation0.65628808
97MP0009765_abnormal_xenobiotic_induced0.65082561
98MP0002075_abnormal_coat/hair_pigmentati0.64978707
99MP0000477_abnormal_intestine_morphology0.64596273
100MP0005164_abnormal_response_to0.63902919
101MP0003300_gastrointestinal_ulcer0.63462920
102MP0008874_decreased_physiological_sensi0.62602635
103MP0001764_abnormal_homeostasis0.62505520
104MP0005409_darkened_coat_color0.62408188
105MP0005058_abnormal_lysosome_morphology0.61793097
106MP0003690_abnormal_glial_cell0.60798081
107MP0002277_abnormal_respiratory_mucosa0.60089629
108MP0003795_abnormal_bone_structure0.59172587
109MP0005084_abnormal_gallbladder_morpholo0.58942494
110MP0000249_abnormal_blood_vessel0.57654254
111MP0004130_abnormal_muscle_cell0.57149363
112MP0010352_gastrointestinal_tract_polyps0.56549703
113MP0005535_abnormal_body_temperature0.56508302
114MP0003191_abnormal_cellular_cholesterol0.54878147
115MP0009697_abnormal_copulation0.53079660
116MP0004381_abnormal_hair_follicle0.52852657
117MP0001851_eye_inflammation0.52602707
118MP0000598_abnormal_liver_morphology0.52585691
119MP0005381_digestive/alimentary_phenotyp0.51637066
120MP0008873_increased_physiological_sensi0.51566085
121MP0005319_abnormal_enzyme/_coenzyme0.51112419
122MP0002693_abnormal_pancreas_physiology0.50244039
123MP0003638_abnormal_response/metabolism_0.47766578
124MP0009642_abnormal_blood_homeostasis0.46814498
125MP0001348_abnormal_lacrimal_gland0.46571067
126MP0000681_abnormal_thyroid_gland0.45155981
127MP0001188_hyperpigmentation0.44910737
128MP0005376_homeostasis/metabolism_phenot0.44637267

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.07243105
2Aplastic anemia (HP:0001915)5.00774710
3Abnormal number of erythroid precursors (HP:0012131)4.87775597
4Abnormality of cells of the erythroid lineage (HP:0012130)4.84503512
5IgM deficiency (HP:0002850)4.76061734
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.36205518
7Chronic obstructive pulmonary disease (HP:0006510)4.33705364
8Obstructive lung disease (HP:0006536)4.33705364
9Chronic otitis media (HP:0000389)4.28761699
10Elevated erythrocyte sedimentation rate (HP:0003565)4.25647026
11Petechiae (HP:0000967)4.12926251
12Reticulocytopenia (HP:0001896)4.08674659
13Optic neuritis (HP:0100653)3.74426008
14Retrobulbar optic neuritis (HP:0100654)3.74426008
15Prolonged bleeding time (HP:0003010)3.73459438
16Recurrent bronchitis (HP:0002837)3.63174517
17Abnormality of T cell physiology (HP:0011840)3.51852043
18Increased IgE level (HP:0003212)3.47936675
19Recurrent gram-negative bacterial infections (HP:0005420)3.47167822
20Myositis (HP:0100614)3.40533253
21Recurrent abscess formation (HP:0002722)3.38652563
22Type 2 muscle fiber atrophy (HP:0003554)3.32389839
23Muscle fiber atrophy (HP:0100295)3.31515147
24Abnormal platelet volume (HP:0011876)3.29389090
25IgG deficiency (HP:0004315)3.27981207
26Pallor (HP:0000980)3.24584708
27Epistaxis (HP:0000421)3.20248635
28Chest pain (HP:0100749)3.15499506
29Panhypogammaglobulinemia (HP:0003139)3.12754544
30Type I transferrin isoform profile (HP:0003642)3.11297776
31Gastrointestinal infarctions (HP:0005244)3.07962990
32Reduced antithrombin III activity (HP:0001976)3.03513442
33Abnormality of T cells (HP:0002843)3.01968219
34Recurrent viral infections (HP:0004429)2.93833455
35Recurrent bacterial skin infections (HP:0005406)2.91791566
36Urticaria (HP:0001025)2.85563827
37Abnormality of the nasal mucosa (HP:0000433)2.83911819
38Episodic fever (HP:0001954)2.82023107
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.76044223
40Keratoconjunctivitis (HP:0001096)2.74777821
41Keratoconjunctivitis sicca (HP:0001097)2.74374823
42Pulmonary infiltrates (HP:0002113)2.73275250
43Agammaglobulinemia (HP:0004432)2.70872055
44Hypochromic anemia (HP:0001931)2.70401382
45Impaired platelet aggregation (HP:0003540)2.69672923
46Abnormal platelet function (HP:0011869)2.69672923
47Increased mean platelet volume (HP:0011877)2.69330325
48Recurrent fungal infections (HP:0002841)2.67753021
49B lymphocytopenia (HP:0010976)2.66512183
50Abnormality of B cell number (HP:0010975)2.66512183
51Abnormality of iron homeostasis (HP:0011031)2.66314452
52Nasal polyposis (HP:0100582)2.66186639
53Increased serum ferritin (HP:0003281)2.65186854
54Meningitis (HP:0001287)2.63938820
55Hemoptysis (HP:0002105)2.62506357
56Lymphoma (HP:0002665)2.62407119
57Menorrhagia (HP:0000132)2.60217237
58Abnormal protein glycosylation (HP:0012346)2.60086960
59Abnormal glycosylation (HP:0012345)2.60086960
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60086960
61Abnormal protein N-linked glycosylation (HP:0012347)2.60086960
62Myelodysplasia (HP:0002863)2.59876888
63Pancytopenia (HP:0001876)2.58728539
64Hypochromic microcytic anemia (HP:0004840)2.58694198
65Lymphopenia (HP:0001888)2.58310214
66Autoimmune thrombocytopenia (HP:0001973)2.55072762
67Cellulitis (HP:0100658)2.55040693
68Eosinophilia (HP:0001880)2.54374115
69Stomatitis (HP:0010280)2.52978977
70Eczematoid dermatitis (HP:0000976)2.51716805
71Gingivitis (HP:0000230)2.50246624
72Arterial thrombosis (HP:0004420)2.49076370
73Hypertensive crisis (HP:0100735)2.48609138
74Macrocytic anemia (HP:0001972)2.48553395
75Abnormality of cells of the lymphoid lineage (HP:0012140)2.47977938
76Oral leukoplakia (HP:0002745)2.46360770
77Hepatosplenomegaly (HP:0001433)2.43830794
78Colitis (HP:0002583)2.41847332
79Abnormality of the prostate (HP:0008775)2.41671061
80Gastrointestinal stroma tumor (HP:0100723)2.40268448
81Poikiloderma (HP:0001029)2.39302939
82Amaurosis fugax (HP:0100576)2.37452909
83Recurrent skin infections (HP:0001581)2.36872920
84Abnormality of eosinophils (HP:0001879)2.36277643
85Chronic mucocutaneous candidiasis (HP:0002728)2.35907588
86Recurrent cutaneous fungal infections (HP:0011370)2.35907588
873-Methylglutaconic aciduria (HP:0003535)2.33394271
88Abnormality of transition element cation homeostasis (HP:0011030)2.33004933
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32024081
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32024081
91Stomach cancer (HP:0012126)2.31863967
92Neutropenia (HP:0001875)2.31733343
93Vasculitis (HP:0002633)2.30421461
94Pulmonary embolism (HP:0002204)2.28360679
9511 pairs of ribs (HP:0000878)2.26721012
96Microcytic anemia (HP:0001935)2.26720789
97IgA deficiency (HP:0002720)2.26113813
98Increased IgM level (HP:0003496)2.24795426
99Gastrointestinal inflammation (HP:0004386)2.23845910
100Seborrheic dermatitis (HP:0001051)2.22825003
101Inflammation of the large intestine (HP:0002037)2.20538140
102Increased cerebral lipofuscin (HP:0011813)2.18630984
103Increased neuronal autofluorescent lipopigment (HP:0002074)2.16565893
104Abnormality of the pleura (HP:0002103)2.15334045
105Fatigue (HP:0012378)2.14617083
106Anorexia (HP:0002039)2.14407263
107Gingival bleeding (HP:0000225)2.13508839
108Hepatocellular necrosis (HP:0001404)2.12841213
109Joint swelling (HP:0001386)2.12500419
110Mediastinal lymphadenopathy (HP:0100721)2.12138231
111Combined immunodeficiency (HP:0005387)2.11167187
112Purpura (HP:0000979)2.11079294
113Hypoproteinemia (HP:0003075)2.10918204
114Acute myeloid leukemia (HP:0004808)2.10648486
115Sepsis (HP:0100806)2.10388141
116Hypoplasia of the thymus (HP:0000778)2.09183045
117Osteomyelitis (HP:0002754)2.08594421
118Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08400820
119Birth length less than 3rd percentile (HP:0003561)2.08093003
120Autoimmune hemolytic anemia (HP:0001890)2.07215088
121Recurrent sinusitis (HP:0011108)2.07118703
122Vertigo (HP:0002321)2.06905576
123Skin rash (HP:0000988)2.03547136
124Encephalitis (HP:0002383)2.02884406
125Aplasia/Hypoplasia of the thymus (HP:0010515)2.02870967
126Chronic sinusitis (HP:0011109)2.02687313
127T lymphocytopenia (HP:0005403)2.02283838
128Acute lymphatic leukemia (HP:0006721)2.01962632
129Orchitis (HP:0100796)2.01748104
130Abnormality of macrophages (HP:0004311)2.01637501
131Spontaneous hematomas (HP:0007420)2.01462259
132Pustule (HP:0200039)2.01236611
133Bronchitis (HP:0012387)2.01025293
134Albinism (HP:0001022)1.99802387
135Hypergammaglobulinemia (HP:0010702)1.99670398
136Abnormality of the fingertips (HP:0001211)1.98753262
137Skin ulcer (HP:0200042)1.98105009
138Abnormality of DNA repair (HP:0003254)1.96950970
139Bone marrow hypocellularity (HP:0005528)1.96736448
140Leukocytosis (HP:0001974)1.95008473
141Viral hepatitis (HP:0006562)1.94815690
142Granulocytopenia (HP:0001913)1.94812037
143Abnormality of T cell number (HP:0011839)1.94147693
144Verrucae (HP:0200043)1.93307676
145Papilloma (HP:0012740)1.93307676
146Severe combined immunodeficiency (HP:0004430)1.92953640
147Hepatic necrosis (HP:0002605)1.92528941
148Vacuolated lymphocytes (HP:0001922)1.91847111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.83510665
2NME23.25776201
3KIT2.89693934
4STK162.87403318
5TXK2.75411426
6MAP3K122.43505216
7TEC2.27664752
8BTK2.25817949
9CDK192.21537998
10MUSK2.17454064
11ZAP702.14878378
12TGFBR12.02563214
13FLT32.00747055
14PRPF4B2.00215671
15WEE11.98285647
16JAK31.93355020
17MAP3K131.92207229
18PIM21.92181902
19TNIK1.86089366
20IKBKE1.85644144
21EEF2K1.79670199
22BLK1.77673919
23TGFBR21.75453817
24IRAK41.72237063
25CSK1.71792400
26MAP2K31.64915634
27SYK1.59677591
28KDR1.56771684
29TBK11.54826835
30TIE11.51919265
31CSF1R1.49045209
32BRSK21.39932886
33TYK21.37273630
34ACVR1B1.33036897
35DYRK31.25721839
36EIF2AK11.25558319
37RPS6KB21.25170365
38VRK11.23303351
39IKBKB1.20692709
40MATK1.17322708
41LYN1.15529335
42ERN11.14943415
43RPS6KA41.13944260
44LCK1.11438614
45CAMKK21.11254985
46MARK31.10462572
47MAP3K31.09946615
48TAOK31.09865610
49FGR1.08213322
50LRRK21.04826890
51BMPR21.04201925
52MAP2K21.03042622
53PIM11.02873751
54CCNB11.02735756
55TAOK11.00368930
56SRPK10.98807156
57BUB10.98022239
58MAP3K70.94408434
59MAP3K10.93884453
60IRAK30.91877719
61CLK10.91739176
62PRKCQ0.91544277
63NLK0.91535561
64MAPK120.90039116
65FES0.89580884
66CDK80.87231156
67STK100.86967557
68EIF2AK30.86876712
69ITK0.86265865
70MKNK10.84672047
71TAOK20.83764176
72PASK0.83074660
73HCK0.81416812
74TESK20.80635483
75ATR0.78394899
76SCYL20.77886317
77CDK70.77327519
78CDC70.77205340
79BCKDK0.76923454
80PRKD20.76916269
81MAP2K60.76494685
82PDK10.76291703
83MAPK70.75314952
84MAPKAPK50.73503543
85PIK3CG0.72485486
86MYLK0.72002948
87PRKG20.69936911
88RPS6KC10.69885765
89RPS6KL10.69885765
90MAPKAPK30.69811117
91EPHB10.69140092
92MAP3K110.68102143
93HIPK20.68023502
94RIPK40.66181518
95TNK20.65804696
96MARK20.65365036
97MAP3K140.63643633
98GRK60.63052374
99RAF10.60896117
100NEK20.60393387
101ADRBK20.59382834
102SIK20.58919163
103DAPK10.58640456
104FYN0.57647834
105TLK10.57068147
106CAMK10.56317558
107DYRK1B0.55559316
108CDK40.54682033
109MAP3K50.54465253
110PTK2B0.53983245
111FGFR40.52296754
112CAMKK10.50581823
113PLK40.49438352
114MKNK20.49240147
115GRK70.49053054
116MAPK40.48300000
117PKN20.47821926
118MAP2K40.47022676
119BMX0.46730697
120BRSK10.46611322
121GRK10.46233916
122MAP3K60.45784272
123RPS6KA60.45241846
124SIK30.45102170
125PDPK10.44355128
126AURKB0.43931603
127JAK20.42790067
128YES10.41331793
129IRAK10.41080644
130JAK10.40399364
131MAPK110.39869966
132STK40.39820203
133MAPK30.38079624
134NUAK10.37273954
135VRK20.36581284
136EIF2AK20.35148447
137CHUK0.35130695
138PTK60.34457810
139DAPK20.34010952
140STK110.32230777
141CDK60.30920217
142ABL10.30196431
143RPS6KA20.28655410
144TRPM70.28305858
145PRKD10.28029922
146MAPKAPK20.27305811
147RET0.27099448
148CDC42BPA0.26741186
149PRKCD0.25794034

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.61501131
2DNA replication_Homo sapiens_hsa030304.06862862
3Primary immunodeficiency_Homo sapiens_hsa053403.34448943
4Mismatch repair_Homo sapiens_hsa034303.00528367
5Base excision repair_Homo sapiens_hsa034102.53229951
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44724797
7Homologous recombination_Homo sapiens_hsa034402.42921900
8Staphylococcus aureus infection_Homo sapiens_hsa051502.31833453
9Type I diabetes mellitus_Homo sapiens_hsa049402.30935124
10Pyrimidine metabolism_Homo sapiens_hsa002402.04745816
11Nucleotide excision repair_Homo sapiens_hsa034201.98982282
12Spliceosome_Homo sapiens_hsa030401.96873657
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.84855422
14Hematopoietic cell lineage_Homo sapiens_hsa046401.81743867
15RNA polymerase_Homo sapiens_hsa030201.81689864
16Non-homologous end-joining_Homo sapiens_hsa034501.78973599
17Measles_Homo sapiens_hsa051621.76868395
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73127580
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70878636
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.68832011
21Proteasome_Homo sapiens_hsa030501.68758018
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65308632
23Leishmaniasis_Homo sapiens_hsa051401.64506348
24Herpes simplex infection_Homo sapiens_hsa051681.64476664
25Antigen processing and presentation_Homo sapiens_hsa046121.62061511
26B cell receptor signaling pathway_Homo sapiens_hsa046621.59311319
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59137153
28Allograft rejection_Homo sapiens_hsa053301.53788645
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51897152
30RNA degradation_Homo sapiens_hsa030181.44529228
31Protein export_Homo sapiens_hsa030601.36608505
32Fanconi anemia pathway_Homo sapiens_hsa034601.32979498
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.22984907
34N-Glycan biosynthesis_Homo sapiens_hsa005101.18092822
35Rheumatoid arthritis_Homo sapiens_hsa053231.18025655
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17415246
37Cell cycle_Homo sapiens_hsa041101.15185452
38Asthma_Homo sapiens_hsa053101.14614885
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12638296
40Purine metabolism_Homo sapiens_hsa002301.10824956
41RNA transport_Homo sapiens_hsa030131.10544880
42Pentose phosphate pathway_Homo sapiens_hsa000301.09279462
43Other glycan degradation_Homo sapiens_hsa005111.07682777
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07621741
45Legionellosis_Homo sapiens_hsa051341.06029458
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04070484
47Acute myeloid leukemia_Homo sapiens_hsa052211.02679417
48T cell receptor signaling pathway_Homo sapiens_hsa046601.00424268
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00182351
50p53 signaling pathway_Homo sapiens_hsa041150.99341946
51Basal transcription factors_Homo sapiens_hsa030220.98704396
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98546599
53Platelet activation_Homo sapiens_hsa046110.97597778
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97485822
55Osteoclast differentiation_Homo sapiens_hsa043800.95862319
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94971888
57Sulfur relay system_Homo sapiens_hsa041220.94445454
58Regulation of autophagy_Homo sapiens_hsa041400.93947345
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92969702
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92370737
61Folate biosynthesis_Homo sapiens_hsa007900.89910413
62Malaria_Homo sapiens_hsa051440.89427856
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88704622
64Shigellosis_Homo sapiens_hsa051310.87617631
65Phagosome_Homo sapiens_hsa041450.84620431
66Hepatitis B_Homo sapiens_hsa051610.84242614
67Influenza A_Homo sapiens_hsa051640.84172065
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83595244
69Pertussis_Homo sapiens_hsa051330.82158035
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79762655
71Epstein-Barr virus infection_Homo sapiens_hsa051690.79167529
72One carbon pool by folate_Homo sapiens_hsa006700.78391799
73Autoimmune thyroid disease_Homo sapiens_hsa053200.75291481
74Toxoplasmosis_Homo sapiens_hsa051450.72879531
75Apoptosis_Homo sapiens_hsa042100.72840968
76Systemic lupus erythematosus_Homo sapiens_hsa053220.71928775
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.71424268
78Viral myocarditis_Homo sapiens_hsa054160.68395385
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67046098
80Arachidonic acid metabolism_Homo sapiens_hsa005900.65606966
81Caffeine metabolism_Homo sapiens_hsa002320.65317764
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63477818
83Lysosome_Homo sapiens_hsa041420.63323567
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61986541
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61840851
86VEGF signaling pathway_Homo sapiens_hsa043700.61142002
87Inositol phosphate metabolism_Homo sapiens_hsa005620.59636120
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57815000
89Viral carcinogenesis_Homo sapiens_hsa052030.57526881
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56051460
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55872858
92Endocytosis_Homo sapiens_hsa041440.52924723
93Tuberculosis_Homo sapiens_hsa051520.52920099
94Galactose metabolism_Homo sapiens_hsa000520.52414688
95HTLV-I infection_Homo sapiens_hsa051660.50965875
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.50768586
97Prolactin signaling pathway_Homo sapiens_hsa049170.50566856
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48963973
99TNF signaling pathway_Homo sapiens_hsa046680.47063272
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.46045362
101Thyroid cancer_Homo sapiens_hsa052160.45898486
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44351373
103Chemokine signaling pathway_Homo sapiens_hsa040620.44131559
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.43905286
105Choline metabolism in cancer_Homo sapiens_hsa052310.43798837
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.43476687
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43281381
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.42891370
109Chronic myeloid leukemia_Homo sapiens_hsa052200.42529180
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.41951311
111Salmonella infection_Homo sapiens_hsa051320.41922941
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.41487687
113Graft-versus-host disease_Homo sapiens_hsa053320.39074372
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38762263
115mTOR signaling pathway_Homo sapiens_hsa041500.37845217
116Hepatitis C_Homo sapiens_hsa051600.37782730
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36024869
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33089449
119FoxO signaling pathway_Homo sapiens_hsa040680.32600641
120MAPK signaling pathway_Homo sapiens_hsa040100.32186259
121Amoebiasis_Homo sapiens_hsa051460.30675634
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30284052
123African trypanosomiasis_Homo sapiens_hsa051430.28330862
124Insulin resistance_Homo sapiens_hsa049310.27968315
125mRNA surveillance pathway_Homo sapiens_hsa030150.27694258
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27407312
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27117239
128ABC transporters_Homo sapiens_hsa020100.27090047
129Non-small cell lung cancer_Homo sapiens_hsa052230.26889173
130Pancreatic cancer_Homo sapiens_hsa052120.25122654
131Small cell lung cancer_Homo sapiens_hsa052220.24732438
132Colorectal cancer_Homo sapiens_hsa052100.24701656
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22459527
134Dorso-ventral axis formation_Homo sapiens_hsa043200.22401738
135Notch signaling pathway_Homo sapiens_hsa043300.21672401
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20999493
137Glycerolipid metabolism_Homo sapiens_hsa005610.20432333

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