TSPAN13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.46217849
2vocalization behavior (GO:0071625)4.40656276
3ionotropic glutamate receptor signaling pathway (GO:0035235)4.36527552
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33871657
5neuron cell-cell adhesion (GO:0007158)4.31712546
6protein localization to synapse (GO:0035418)4.31665308
7glutamate receptor signaling pathway (GO:0007215)4.27096987
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.25373570
9Golgi transport vesicle coating (GO:0048200)4.10377658
10COPI coating of Golgi vesicle (GO:0048205)4.10377658
11gamma-aminobutyric acid signaling pathway (GO:0007214)4.04571174
12protein maturation by protein folding (GO:0022417)3.99691496
13regulation of synaptic vesicle exocytosis (GO:2000300)3.99308292
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95010259
15regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.93757735
16regulation of glutamate receptor signaling pathway (GO:1900449)3.92756199
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89173285
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87436620
19pyrimidine nucleobase catabolic process (GO:0006208)3.83146079
20positive regulation of neurotransmitter secretion (GO:0001956)3.76872332
21regulation of synaptic vesicle transport (GO:1902803)3.74823968
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73909063
23exploration behavior (GO:0035640)3.71848065
24positive regulation of dendritic spine morphogenesis (GO:0061003)3.71345150
25neuron recognition (GO:0008038)3.70402795
26synaptic transmission, glutamatergic (GO:0035249)3.67259114
27regulation of axon regeneration (GO:0048679)3.67018223
28regulation of neuron projection regeneration (GO:0070570)3.67018223
29neuron-neuron synaptic transmission (GO:0007270)3.64805500
30G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.63535353
31neuronal action potential propagation (GO:0019227)3.54284771
32detection of calcium ion (GO:0005513)3.48735371
33nucleobase catabolic process (GO:0046113)3.47448246
34response to histamine (GO:0034776)3.45852475
35postsynaptic membrane organization (GO:0001941)3.43411288
36axonemal dynein complex assembly (GO:0070286)3.38560765
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38193669
38fear response (GO:0042596)3.30462879
39regulation of vesicle fusion (GO:0031338)3.29458323
40long-term synaptic potentiation (GO:0060291)3.28977695
41adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.28973439
42regulation of neuronal synaptic plasticity (GO:0048168)3.27377529
43behavioral fear response (GO:0001662)3.26953643
44behavioral defense response (GO:0002209)3.26953643
45regulation of postsynaptic membrane potential (GO:0060078)3.25680280
46intestinal epithelial cell development (GO:0060576)3.24775672
47presynaptic membrane assembly (GO:0097105)3.23050947
48negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.21731314
49synaptic vesicle maturation (GO:0016188)3.21297590
50locomotory exploration behavior (GO:0035641)3.20603916
51positive regulation of synapse maturation (GO:0090129)3.20602100
52glutamate secretion (GO:0014047)3.19322656
53innervation (GO:0060384)3.17689297
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12583954
55negative regulation of cell killing (GO:0031342)3.12583954
56regulation of synapse structural plasticity (GO:0051823)3.10773165
57synaptic vesicle endocytosis (GO:0048488)3.10510241
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10251243
59axonal fasciculation (GO:0007413)3.09127702
60long-term memory (GO:0007616)3.08129178
61positive regulation of cellular response to oxidative stress (GO:1900409)3.08032945
62positive regulation of response to oxidative stress (GO:1902884)3.08032945
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.07229353
64positive regulation of neurotransmitter transport (GO:0051590)3.05923148
65regulation of catecholamine metabolic process (GO:0042069)3.04313109
66regulation of dopamine metabolic process (GO:0042053)3.04313109
67dendritic spine organization (GO:0097061)3.04187527
68positive regulation of membrane potential (GO:0045838)3.01595328
69cochlea development (GO:0090102)3.00603608
70apical protein localization (GO:0045176)3.00269828
71regulation of synaptic plasticity (GO:0048167)3.00000316
72regulation of actin nucleation (GO:0051125)2.98959481
73glycosphingolipid biosynthetic process (GO:0006688)2.97909911
74surfactant homeostasis (GO:0043129)2.97332364
75positive regulation of dendritic spine development (GO:0060999)2.97177250
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96313492
77phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.95532818
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.94166885
79regulation of dendritic spine morphogenesis (GO:0061001)2.92980172
80regulation of glutamate secretion (GO:0014048)2.91817108
81dendritic spine morphogenesis (GO:0060997)2.91087520
82neurotransmitter secretion (GO:0007269)2.89284049
83synaptic vesicle docking involved in exocytosis (GO:0016081)2.88524177
84protein localization to cilium (GO:0061512)2.87932394
85serotonin metabolic process (GO:0042428)2.87615277
86catecholamine transport (GO:0051937)2.86653591
87negative regulation of microtubule polymerization (GO:0031115)2.84402352
88regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.84329375
89epithelial cell maturation (GO:0002070)2.83916600
90cellular potassium ion homeostasis (GO:0030007)2.82214741
91chemosensory behavior (GO:0007635)2.82006295
92response to amphetamine (GO:0001975)2.80950600
93presynaptic membrane organization (GO:0097090)2.79118865
94learning (GO:0007612)2.77175917
95calcium-mediated signaling using intracellular calcium source (GO:0035584)2.76742020
96synaptic transmission, dopaminergic (GO:0001963)2.76368066
97transmission of nerve impulse (GO:0019226)2.75766400
98synaptic vesicle transport (GO:0048489)2.74456347
99establishment of synaptic vesicle localization (GO:0097480)2.74456347
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71105099
101long term synaptic depression (GO:0060292)2.71104075
102vesicle transport along microtubule (GO:0047496)2.70488994
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69237665
104maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68215814
105establishment of mitochondrion localization (GO:0051654)2.68154594
106regulation of inositol phosphate biosynthetic process (GO:0010919)2.67159787
107sodium ion export (GO:0071436)2.66537808
108membrane depolarization (GO:0051899)2.66381074
109chemical homeostasis within a tissue (GO:0048875)2.65793144
110startle response (GO:0001964)2.65557902
111regulation of neurotransmitter secretion (GO:0046928)2.65247795
112layer formation in cerebral cortex (GO:0021819)2.65151415
113synapse assembly (GO:0007416)2.64945185
114activation of protein kinase A activity (GO:0034199)2.64772180
115righting reflex (GO:0060013)2.62680802
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61994691
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61953797
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.61813266
119endoplasmic reticulum organization (GO:0007029)2.58341921
120primary alcohol catabolic process (GO:0034310)2.58141573
121NADH metabolic process (GO:0006734)2.57687158
122protein retention in ER lumen (GO:0006621)2.57545786
123cilium movement (GO:0003341)2.56348759
124L-serine transport (GO:0015825)2.52959171
125regulation of clathrin-mediated endocytosis (GO:2000369)2.52303192
126norepinephrine metabolic process (GO:0042415)2.52277497
127vitamin transmembrane transport (GO:0035461)2.48270142
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47742751
129regulation of autophagic vacuole assembly (GO:2000785)2.45570979
130neurotransmitter catabolic process (GO:0042135)2.45199741
131vesicle coating (GO:0006901)2.43435799
132peptidyl-cysteine modification (GO:0018198)2.42722816
133organelle transport along microtubule (GO:0072384)2.41959613
134asymmetric protein localization (GO:0008105)2.40972431
135neurofilament cytoskeleton organization (GO:0060052)2.39247318
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.38495681
137substrate-independent telencephalic tangential migration (GO:0021826)2.38495681
138epithelial cilium movement (GO:0003351)2.37529853
139COPII vesicle coating (GO:0048208)2.37275467
140cell migration in hindbrain (GO:0021535)2.34185117
141ear development (GO:0043583)2.32743398
142cell communication involved in cardiac conduction (GO:0086065)2.31988461
143membrane budding (GO:0006900)2.30988798
144positive regulation of protein targeting to membrane (GO:0090314)2.28529138
145protein insertion into membrane (GO:0051205)2.26156646
146sodium ion homeostasis (GO:0055078)2.25972335
147neurotransmitter biosynthetic process (GO:0042136)2.25871092
148positive regulation of mitochondrial fission (GO:0090141)2.25351219
149transferrin transport (GO:0033572)2.25316116
150regulation of neurotransmitter levels (GO:0001505)2.25205312
151cellular sodium ion homeostasis (GO:0006883)2.24192776
152prostate gland growth (GO:0060736)2.24183616
153regulation of protein targeting to membrane (GO:0090313)2.23491149
154mating behavior (GO:0007617)2.22491614
155growth hormone secretion (GO:0030252)2.22405334
156trivalent inorganic cation transport (GO:0072512)2.20951117
157ferric iron transport (GO:0015682)2.20951117
158regulation of cAMP-dependent protein kinase activity (GO:2000479)2.20677695
159peroxisome fission (GO:0016559)2.20217049
160dendrite morphogenesis (GO:0048813)2.19995473
161establishment of melanosome localization (GO:0032401)2.16631699
162dopamine receptor signaling pathway (GO:0007212)2.15673384
163cell communication by electrical coupling (GO:0010644)2.15060974
164ATP hydrolysis coupled proton transport (GO:0015991)2.15039360
165energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.15039360
166intraciliary transport (GO:0042073)2.14335502
167cilium or flagellum-dependent cell motility (GO:0001539)2.13636961
168cerebellar Purkinje cell layer development (GO:0021680)2.13283182
169regulation of vacuole organization (GO:0044088)2.13218707
170diterpenoid biosynthetic process (GO:0016102)2.12680077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.03461553
2GBX2_23144817_ChIP-Seq_PC3_Human4.10046491
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.63033433
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07919405
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06528591
6REST_21632747_ChIP-Seq_MESCs_Mouse2.96931566
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77571624
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.72573221
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58233508
10TAF15_26573619_Chip-Seq_HEK293_Human2.54013448
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50342209
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47820356
13IGF1R_20145208_ChIP-Seq_DFB_Human2.40778444
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40496279
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.38970923
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.35592604
17ZNF274_21170338_ChIP-Seq_K562_Hela2.35236029
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33341013
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31796630
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.31130147
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.29229536
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27091679
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25903752
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24623924
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24623924
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.21285876
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18052666
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16411256
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11657126
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.04972376
31ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04258800
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99270004
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97604278
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96178081
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.94540309
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91281883
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.91035123
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90891530
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.86294737
40AHR_22903824_ChIP-Seq_MCF-7_Human1.84937401
41P300_19829295_ChIP-Seq_ESCs_Human1.83385877
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82845309
43VDR_22108803_ChIP-Seq_LS180_Human1.78414529
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74571011
45ZNF263_19887448_ChIP-Seq_K562_Human1.74478558
46SMAD4_21799915_ChIP-Seq_A2780_Human1.73224162
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70863454
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68878476
49FUS_26573619_Chip-Seq_HEK293_Human1.66253399
50DROSHA_22980978_ChIP-Seq_HELA_Human1.62253358
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58843840
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51803554
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50431096
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47797758
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46057322
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.45856002
57AR_25329375_ChIP-Seq_VCAP_Human1.44584785
58CLOCK_20551151_ChIP-Seq_293T_Human1.42797387
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42582535
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41021065
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40930098
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32767514
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.28982645
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27086632
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26500726
66SOX2_20726797_ChIP-Seq_SW620_Human1.25957740
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25281543
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.24600083
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.22598191
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.20356373
71RNF2_27304074_Chip-Seq_NSC_Mouse1.17470442
72* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16552625
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14911653
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14415889
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13786766
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13042122
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09567803
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09449257
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09204509
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09116235
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.07965559
82* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07408926
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07384531
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.07364407
85ER_23166858_ChIP-Seq_MCF-7_Human1.06839568
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.05525591
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05431966
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.05229479
89BCAT_22108803_ChIP-Seq_LS180_Human1.04795469
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04158382
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04128230
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03687312
93FOXA1_25552417_ChIP-Seq_VCAP_Human1.02620553
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01754112
95JUN_21703547_ChIP-Seq_K562_Human1.01278389
96RUNX2_22187159_ChIP-Seq_PCA_Human1.01076123
97TP53_22573176_ChIP-Seq_HFKS_Human1.00791806
98STAT3_23295773_ChIP-Seq_U87_Human1.00211375
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.00006283
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.97960185
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97088473
102P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96369441
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96338682
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95910460
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95831817
106EWS_26573619_Chip-Seq_HEK293_Human0.95732242
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.95699492
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95543439
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95128408
110* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94758903
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94276513
112TCF4_23295773_ChIP-Seq_U87_Human0.93828395
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.92185612
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90158536
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89896438
116ELF5_23300383_ChIP-Seq_T47D_Human0.88567666
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88292714
118KDM2B_26808549_Chip-Seq_REH_Human0.88142314
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88061517
120GATA4_25053715_ChIP-Seq_YYC3_Human0.88002240
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87810779
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.86959064
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86249571
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.85946924
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85746102
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85718556
127* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85248019
128* CBP_20019798_ChIP-Seq_JUKART_Human0.85248019
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84809045
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.84622355
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84432866
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83717557
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83077538
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83077538
135HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82656870
136AR_19668381_ChIP-Seq_PC3_Human0.82071479
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81832875
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81691060
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.81398570
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80630553
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80242817
142TP53_18474530_ChIP-ChIP_U2OS_Human0.79999644
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78716363
144KLF5_25053715_ChIP-Seq_YYC3_Human0.78689233
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78558410
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75784455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.68782394
2MP0004859_abnormal_synaptic_plasticity4.92006718
3MP0003635_abnormal_synaptic_transmissio3.59152933
4MP0004270_analgesia3.08423101
5MP0010234_abnormal_vibrissa_follicle3.07769971
6MP0004782_abnormal_surfactant_physiolog3.01819500
7MP0002063_abnormal_learning/memory/cond2.99853304
8MP0009745_abnormal_behavioral_response2.93184889
9MP0001968_abnormal_touch/_nociception2.72791150
10MP0001188_hyperpigmentation2.51698183
11MP0002572_abnormal_emotion/affect_behav2.50989060
12MP0006276_abnormal_autonomic_nervous2.47082750
13MP0002736_abnormal_nociception_after2.40326374
14MP0002909_abnormal_adrenal_gland2.37166115
15MP0001501_abnormal_sleep_pattern2.36421929
16MP0002064_seizures2.35480528
17MP0002837_dystrophic_cardiac_calcinosis2.31094915
18MP0002272_abnormal_nervous_system2.24010492
19MP0004264_abnormal_extraembryonic_tissu2.20347107
20MP0010386_abnormal_urinary_bladder2.09596242
21MP0002735_abnormal_chemical_nociception2.09544191
22MP0005423_abnormal_somatic_nervous2.01714463
23MP0001529_abnormal_vocalization1.99037340
24MP0002734_abnormal_mechanical_nocicepti1.98698610
25MP0005645_abnormal_hypothalamus_physiol1.92707378
26MP0001440_abnormal_grooming_behavior1.90225258
27MP0009780_abnormal_chondrocyte_physiolo1.80290683
28MP0002184_abnormal_innervation1.78205147
29MP0002067_abnormal_sensory_capabilities1.75686780
30MP0002733_abnormal_thermal_nociception1.75080537
31MP0001486_abnormal_startle_reflex1.73346899
32MP0001984_abnormal_olfaction1.72554793
33MP0001905_abnormal_dopamine_level1.69065313
34MP0001970_abnormal_pain_threshold1.68301915
35MP0009379_abnormal_foot_pigmentation1.65363493
36MP0003879_abnormal_hair_cell1.62634108
37MP0002557_abnormal_social/conspecific_i1.62379099
38MP0002822_catalepsy1.57906570
39MP0006292_abnormal_olfactory_placode1.57795824
40MP0003787_abnormal_imprinting1.53198332
41MP0005409_darkened_coat_color1.53037894
42MP0005083_abnormal_biliary_tract1.52605483
43MP0005646_abnormal_pituitary_gland1.52073646
44MP0001502_abnormal_circadian_rhythm1.50354698
45MP0005386_behavior/neurological_phenoty1.50294417
46MP0004924_abnormal_behavior1.50294417
47MP0009046_muscle_twitch1.50066071
48MP0002796_impaired_skin_barrier1.50056887
49MP0000566_synostosis1.49415620
50MP0000778_abnormal_nervous_system1.46668213
51MP0002653_abnormal_ependyma_morphology1.45890079
52MP0008875_abnormal_xenobiotic_pharmacok1.44207523
53MP0005379_endocrine/exocrine_gland_phen1.43447375
54MP0001346_abnormal_lacrimal_gland1.42794239
55MP0003122_maternal_imprinting1.42713290
56MP0000013_abnormal_adipose_tissue1.38459877
57MP0010678_abnormal_skin_adnexa1.37163806
58MP0005248_abnormal_Harderian_gland1.36986780
59MP0004811_abnormal_neuron_physiology1.36824654
60MP0002693_abnormal_pancreas_physiology1.34694545
61MP0008569_lethality_at_weaning1.28771735
62MP0003329_amyloid_beta_deposits1.28492257
63MP0003183_abnormal_peptide_metabolism1.21778468
64MP0000955_abnormal_spinal_cord1.21712853
65MP0002876_abnormal_thyroid_physiology1.21345346
66MP0002098_abnormal_vibrissa_morphology1.20585428
67MP0000427_abnormal_hair_cycle1.20435346
68MP0006072_abnormal_retinal_apoptosis1.20099160
69MP0001666_abnormal_nutrient_absorption1.19754034
70MP0000537_abnormal_urethra_morphology1.19624010
71MP0001727_abnormal_embryo_implantation1.19429238
72MP0000631_abnormal_neuroendocrine_gland1.19198087
73MP0000462_abnormal_digestive_system1.18894906
74MP0003123_paternal_imprinting1.14698596
75MP0002638_abnormal_pupillary_reflex1.14553648
76MP0001664_abnormal_digestion1.13632798
77MP0002160_abnormal_reproductive_system1.10811896
78MP0002234_abnormal_pharynx_morphology1.09705162
79MP0001177_atelectasis1.09089223
80MP0004145_abnormal_muscle_electrophysio1.08523232
81MP0008995_early_reproductive_senescence1.08325795
82MP0002882_abnormal_neuron_morphology1.07138309
83MP0001944_abnormal_pancreas_morphology1.07038594
84MP0003121_genomic_imprinting1.06942088
85MP0000678_abnormal_parathyroid_gland1.06531515
86MP0002066_abnormal_motor_capabilities/c1.06202023
87MP0005535_abnormal_body_temperature1.01907314
88MP0004215_abnormal_myocardial_fiber1.01768185
89MP0008789_abnormal_olfactory_epithelium1.00437355
90MP0004510_myositis0.98739242
91MP0002163_abnormal_gland_morphology0.96326527
92MP0004484_altered_response_of0.94831870
93MP0000015_abnormal_ear_pigmentation0.93683364
94MP0005174_abnormal_tail_pigmentation0.92405787
95MP0005085_abnormal_gallbladder_physiolo0.91515598
96MP0003633_abnormal_nervous_system0.90900870
97MP0005310_abnormal_salivary_gland0.90615818
98MP0000681_abnormal_thyroid_gland0.87574987
99MP0001765_abnormal_ion_homeostasis0.87365684
100MP0005501_abnormal_skin_physiology0.87051418
101MP0005394_taste/olfaction_phenotype0.86739763
102MP0005499_abnormal_olfactory_system0.86739763
103MP0001986_abnormal_taste_sensitivity0.85110169
104MP0004085_abnormal_heartbeat0.84395889
105MP0001881_abnormal_mammary_gland0.83340977
106MP0002069_abnormal_eating/drinking_beha0.83333224
107MP0000647_abnormal_sebaceous_gland0.82634422
108MP0002152_abnormal_brain_morphology0.81339475
109MP0005551_abnormal_eye_electrophysiolog0.81139504
110MP0000383_abnormal_hair_follicle0.79383942
111MP0005636_abnormal_mineral_homeostasis0.78393357
112MP0001919_abnormal_reproductive_system0.78034393
113MP0004858_abnormal_nervous_system0.75314746
114MP0004133_heterotaxia0.74508076
115MP0003283_abnormal_digestive_organ0.73810412
116MP0001963_abnormal_hearing_physiology0.73225092
117MP0004043_abnormal_pH_regulation0.72482399
118MP0002229_neurodegeneration0.71715746
119MP0008872_abnormal_physiological_respon0.71441533
120MP0004142_abnormal_muscle_tone0.71391254
121MP0003890_abnormal_embryonic-extraembry0.71365005
122MP0005187_abnormal_penis_morphology0.70653514
123MP0010329_abnormal_lipoprotein_level0.69638806
124MP0003942_abnormal_urinary_system0.67645420
125MP0002751_abnormal_autonomic_nervous0.67394751
126MP0004019_abnormal_vitamin_homeostasis0.67366763
127MP0000377_abnormal_hair_follicle0.65783455
128MP0003315_abnormal_perineum_morphology0.65424469
129MP0005084_abnormal_gallbladder_morpholo0.63709667
130MP0003866_abnormal_defecation0.63216494
131MP0008874_decreased_physiological_sensi0.63121969
132MP0003631_nervous_system_phenotype0.62794747
133MP0002877_abnormal_melanocyte_morpholog0.60329259
134MP0008961_abnormal_basal_metabolism0.59896636
135MP0004147_increased_porphyrin_level0.59401860
136MP0002752_abnormal_somatic_nervous0.58825584
137MP0005671_abnormal_response_to0.57680176
138MP0001873_stomach_inflammation0.53262539

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.24502810
2Visual hallucinations (HP:0002367)5.51867762
3Atonic seizures (HP:0010819)4.53964042
4Epileptic encephalopathy (HP:0200134)4.21417146
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20167978
6Focal seizures (HP:0007359)4.13825545
7Febrile seizures (HP:0002373)4.01123499
8Absence seizures (HP:0002121)3.97958296
9Hyperventilation (HP:0002883)3.81350056
10Dialeptic seizures (HP:0011146)3.55463187
11Myokymia (HP:0002411)3.42565896
12Amblyopia (HP:0000646)3.33824918
13Abnormal respiratory motile cilium physiology (HP:0012261)3.25302625
14Abnormal respiratory motile cilium morphology (HP:0005938)3.23364451
15Abnormal respiratory epithelium morphology (HP:0012253)3.23364451
16Rhinitis (HP:0012384)3.23137617
17Chronic bronchitis (HP:0004469)3.15568745
18Progressive inability to walk (HP:0002505)3.09445410
19Type II lissencephaly (HP:0007260)3.06702916
20Truncal ataxia (HP:0002078)3.02030016
21Anxiety (HP:0000739)3.01438248
22Broad-based gait (HP:0002136)2.97170556
23Retinal dysplasia (HP:0007973)2.96427139
24Ankle clonus (HP:0011448)2.94891610
25Protruding tongue (HP:0010808)2.94338238
26Decreased circulating renin level (HP:0003351)2.87412083
27Excessive salivation (HP:0003781)2.86862272
28Drooling (HP:0002307)2.86862272
29Supranuclear gaze palsy (HP:0000605)2.85448611
30Abnormality of the corticospinal tract (HP:0002492)2.84246835
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81020806
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.81020806
33Absent/shortened dynein arms (HP:0200106)2.75372663
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.75372663
35Epileptiform EEG discharges (HP:0011182)2.74527198
36Inability to walk (HP:0002540)2.74406630
37Hypothermia (HP:0002045)2.71402743
38Generalized tonic-clonic seizures (HP:0002069)2.70828723
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69192567
40Cerebral inclusion bodies (HP:0100314)2.67989203
41Insidious onset (HP:0003587)2.65547509
42Termporal pattern (HP:0011008)2.65547509
43Concave nail (HP:0001598)2.63681173
44Urinary urgency (HP:0000012)2.63330132
45Depression (HP:0000716)2.60703408
46Poor eye contact (HP:0000817)2.59044725
47Delusions (HP:0000746)2.57477374
48Acute necrotizing encephalopathy (HP:0006965)2.56852336
49Abnormal mitochondria in muscle tissue (HP:0008316)2.53244274
50Abnormality of binocular vision (HP:0011514)2.51842566
51Diplopia (HP:0000651)2.51842566
52Hydroureter (HP:0000072)2.50609310
53Papilledema (HP:0001085)2.48519091
54EEG with generalized epileptiform discharges (HP:0011198)2.48025732
55Dysautonomia (HP:0002459)2.42887254
56Progressive cerebellar ataxia (HP:0002073)2.42171291
57Akinesia (HP:0002304)2.41617050
58Agitation (HP:0000713)2.40685418
59Curly hair (HP:0002212)2.38425259
60Papillary thyroid carcinoma (HP:0002895)2.36374040
61Impaired smooth pursuit (HP:0007772)2.35072583
62Mutism (HP:0002300)2.34313360
63Gait imbalance (HP:0002141)2.34021220
64Gout (HP:0001997)2.32378136
65Mitochondrial inheritance (HP:0001427)2.28454675
66Stereotypic behavior (HP:0000733)2.28014651
67Progressive macrocephaly (HP:0004481)2.27844790
68Hemiparesis (HP:0001269)2.27095668
69Psychosis (HP:0000709)2.26273276
70Interstitial pulmonary disease (HP:0006530)2.21206606
71Tubulointerstitial nephritis (HP:0001970)2.20575841
72Chronic sinusitis (HP:0011109)2.19289508
73Medial flaring of the eyebrow (HP:0010747)2.17595355
74Hypsarrhythmia (HP:0002521)2.15587526
75Morphological abnormality of the pyramidal tract (HP:0002062)2.14724586
76Infertility (HP:0000789)2.12372407
77Oligomenorrhea (HP:0000876)2.12050901
78Action tremor (HP:0002345)2.10721525
79Spastic gait (HP:0002064)2.09773763
80Hand muscle atrophy (HP:0009130)2.09660678
81Amyotrophic lateral sclerosis (HP:0007354)2.08995511
82Growth hormone excess (HP:0000845)2.07495257
83Congenital primary aphakia (HP:0007707)2.06345595
84Impaired social interactions (HP:0000735)2.03810202
85Abnormal social behavior (HP:0012433)2.03810202
86Hypoglycemic coma (HP:0001325)2.01756393
87Vaginal atresia (HP:0000148)1.98907125
88Diminished movement (HP:0002374)1.98738014
89Impaired vibration sensation in the lower limbs (HP:0002166)1.97921411
90Heterochromia iridis (HP:0001100)1.97758324
91Lissencephaly (HP:0001339)1.96492619
92Pheochromocytoma (HP:0002666)1.96148803
93Bradykinesia (HP:0002067)1.95872593
94Genital tract atresia (HP:0001827)1.95340747
95Nephrogenic diabetes insipidus (HP:0009806)1.94167165
96Abnormal eating behavior (HP:0100738)1.93002011
97Unsteady gait (HP:0002317)1.92525506
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91456243
99Muscular hypotonia of the trunk (HP:0008936)1.91050614
100Abnormality of salivation (HP:0100755)1.90789717
101Neuroendocrine neoplasm (HP:0100634)1.90274587
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89235810
103Absent speech (HP:0001344)1.88219110
104Proximal tubulopathy (HP:0000114)1.87947705
105Diminished motivation (HP:0000745)1.87281484
106Esotropia (HP:0000565)1.87281354
107Hypoplasia of the brainstem (HP:0002365)1.86401267
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86401267
109Gaze-evoked nystagmus (HP:0000640)1.85369486
110Limb dystonia (HP:0002451)1.85229596
111Widely spaced teeth (HP:0000687)1.82904860
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.82716799
113Cortical dysplasia (HP:0002539)1.82410550
114Neurofibrillary tangles (HP:0002185)1.82155138
115Apathy (HP:0000741)1.81553653
116Macroglossia (HP:0000158)1.81441655
117Bronchiectasis (HP:0002110)1.79923305
118Poor suck (HP:0002033)1.79538836
119Failure to thrive in infancy (HP:0001531)1.78430150
120Thyroid carcinoma (HP:0002890)1.76305074
121Hepatocellular necrosis (HP:0001404)1.75828325
122Deep palmar crease (HP:0006191)1.75684017
123Dysmetria (HP:0001310)1.75241195
124Exotropia (HP:0000577)1.75096381
125Abnormality of ocular smooth pursuit (HP:0000617)1.75092899
126Specific learning disability (HP:0001328)1.74976595
127Orthostatic hypotension (HP:0001278)1.74294923
128Degeneration of anterior horn cells (HP:0002398)1.74278225
129Abnormality of the anterior horn cell (HP:0006802)1.74278225
130Rapidly progressive (HP:0003678)1.73621794
131Septate vagina (HP:0001153)1.73298283
132Restlessness (HP:0000711)1.73247052
133Intention tremor (HP:0002080)1.72250046
134Hyperactive renin-angiotensin system (HP:0000841)1.71959627
135Ketoacidosis (HP:0001993)1.71328044
136Increased CSF lactate (HP:0002490)1.71291333
137Hypokinesia (HP:0002375)1.70983864
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.70700945
139Acute encephalopathy (HP:0006846)1.70318797
140Abnormal autonomic nervous system physiology (HP:0012332)1.69601586
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69512948
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69512948
143Tongue fasciculations (HP:0001308)1.69109770
144Abnormal rod and cone electroretinograms (HP:0008323)1.66630210
145Abnormality of renin-angiotensin system (HP:0000847)1.66305120
146Ulnar claw (HP:0001178)1.66176511
147Abnormality of the dental root (HP:0006486)1.65998487
148Taurodontia (HP:0000679)1.65998487
149Abnormality of permanent molar morphology (HP:0011071)1.65998487
150Renal salt wasting (HP:0000127)1.65547269
151Polyphagia (HP:0002591)1.65447230
152Right ventricular cardiomyopathy (HP:0011663)1.65019771
153Intestinal atresia (HP:0011100)1.64948657
154Hypotension (HP:0002615)1.63380690
155Testicular atrophy (HP:0000029)1.63377191
156Generalized hypopigmentation of hair (HP:0011358)1.63344269
157Poor coordination (HP:0002370)1.61566975
158Sparse lateral eyebrow (HP:0005338)1.61276539
159Lower limb muscle weakness (HP:0007340)1.61118186
160Hyperphosphatemia (HP:0002905)1.60940012
161Abnormal hair whorl (HP:0010721)1.60603352
162Abnormal ciliary motility (HP:0012262)1.60020353
163Tetraparesis (HP:0002273)1.59273718
164Autoamputation (HP:0001218)1.57984059
165Testicular neoplasm (HP:0010788)1.57910443
166Breast carcinoma (HP:0003002)1.55994632
167Spastic tetraplegia (HP:0002510)1.55338779
168Hyperaldosteronism (HP:0000859)1.53248977
169Hepatoblastoma (HP:0002884)1.48786879
170Pili torti (HP:0003777)1.47287750
171Sensorimotor neuropathy (HP:0007141)1.47230473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.45034688
2EPHA44.40860336
3RIPK44.24734115
4MAP3K123.70248450
5TESK13.61755621
6EPHA23.33534019
7MAP2K72.82536101
8TRIM282.59557212
9MAP3K42.58122617
10MINK12.50098109
11EIF2AK12.37231414
12CASK2.26073626
13MAP3K92.24624015
14DAPK12.19115185
15TNIK2.18286697
16MARK12.17813909
17BMPR22.15198173
18SIK21.93055826
19MST1R1.89786328
20LIMK11.88553723
21GRK51.82381835
22NME11.81852983
23PNCK1.81205513
24SIK31.77109166
25PLK21.75440251
26PKN21.74788312
27FES1.69854072
28KSR11.62875313
29ERBB31.62507844
30GRK61.56989665
31MAP2K41.56057835
32CDK191.55369883
33MAP3K131.54426466
34MAPK131.53125981
35ARAF1.43072606
36GRK71.42836897
37EPHA31.41341159
38CAMKK21.39873678
39CSNK1G31.38941656
40TSSK61.37083782
41LATS21.36524191
42INSRR1.36173401
43PTK2B1.30188150
44LMTK21.27968127
45DAPK21.27922914
46CDK51.25895872
47KSR21.23010306
48NTRK11.22775511
49MUSK1.18786262
50CSNK1A1L1.17277766
51SYK1.15694734
52MST41.13075210
53DYRK1A1.12298474
54TESK21.07428664
55CSNK1G11.06818823
56STK161.06302457
57RAF11.04661133
58CAMK2B1.04311291
59NTRK21.03602203
60UHMK11.02754864
61BCKDK1.01883587
62STK391.00222471
63CCNB10.99828533
64CAMK2A0.99562999
65EPHB20.99164253
66FGR0.96238833
67PRKCG0.93614706
68OXSR10.92580882
69MET0.91999716
70FLT30.91724541
71ADRBK20.90932977
72PRKCI0.89785136
73PHKG10.88947805
74PHKG20.88947805
75MAP4K20.87833966
76MAPK150.86063868
77CAMK2G0.82509896
78HIPK20.82338844
79TRIB30.81038469
80PINK10.80338302
81TIE10.77594137
82CAMKK10.76662490
83PIK3CA0.73687030
84MAP3K20.72947444
85CAMK10.72782882
86PASK0.72723133
87TNK20.70970271
88PRKCZ0.69830900
89NEK60.67862488
90STK38L0.60796458
91MAP3K10.59621899
92PRKCE0.58550692
93MAP3K60.56331488
94CAMK2D0.55130318
95PRKD30.53342036
96CSNK1E0.53324317
97RPS6KA40.53225102
98KIT0.52984786
99TEC0.52382573
100ADRBK10.51735674
101ERBB20.51080408
102YES10.50434733
103BCR0.48210941
104DYRK1B0.48002646
105LATS10.47675766
106STK240.47255234
107AKT20.46572368
108RET0.46482823
109PRKD20.46292761
110MYLK0.45874586
111CSNK1G20.45565994
112CDK140.44873157
113PTK20.43895274
114DYRK30.43878229
115MARK20.43846374
116SCYL20.42781599
117ICK0.42141252
118PRKAA10.42040886
119PAK60.41896627
120CDK180.41711914
121ILK0.40330947
122MAP2K10.40115395
123GRK10.38844450
124SRPK10.38736138
125RPS6KA20.38489643
126CSNK1A10.37795982
127MAPK120.36388782
128FER0.36107837
129BRAF0.35280373
130PRKACA0.33156550
131MAPKAPK50.32677319
132MAP3K70.32562027
133SGK10.32438543
134MATK0.32315215
135MAPKAPK30.32163109
136CDK150.32067712
137DYRK20.31534478
138CDK11A0.30126291
139VRK10.29170003
140BRD40.29146969
141FYN0.28459938
142MAP2K60.28067654
143CDK80.26747017
144PRKCQ0.26715986
145AKT30.25394287
146PAK30.24599258
147RPS6KB10.23825968
148CDK30.23406342
149WNK30.23094559
150LYN0.22596276
151FRK0.22312262

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.74269939
2Long-term potentiation_Homo sapiens_hsa047202.92999442
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64433846
4Amphetamine addiction_Homo sapiens_hsa050312.60517828
5Circadian entrainment_Homo sapiens_hsa047132.50409654
6Morphine addiction_Homo sapiens_hsa050322.27311875
7Synaptic vesicle cycle_Homo sapiens_hsa047212.26894279
8Glutamatergic synapse_Homo sapiens_hsa047242.23303505
9Olfactory transduction_Homo sapiens_hsa047402.22002692
10Taste transduction_Homo sapiens_hsa047422.21986243
11Dopaminergic synapse_Homo sapiens_hsa047282.19279573
12GABAergic synapse_Homo sapiens_hsa047272.15931999
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07441642
14Insulin secretion_Homo sapiens_hsa049112.06245810
15Salivary secretion_Homo sapiens_hsa049701.97498472
16Renin secretion_Homo sapiens_hsa049241.95062988
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87308821
18Serotonergic synapse_Homo sapiens_hsa047261.85218265
19Phenylalanine metabolism_Homo sapiens_hsa003601.81081584
20Fatty acid elongation_Homo sapiens_hsa000621.75108315
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73035331
22Sulfur metabolism_Homo sapiens_hsa009201.72997529
23Collecting duct acid secretion_Homo sapiens_hsa049661.68455862
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65880887
25Calcium signaling pathway_Homo sapiens_hsa040201.61203983
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60215191
27Long-term depression_Homo sapiens_hsa047301.59715895
28Cholinergic synapse_Homo sapiens_hsa047251.58515780
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54598576
30Alzheimers disease_Homo sapiens_hsa050101.54560442
31Oxidative phosphorylation_Homo sapiens_hsa001901.54088956
32Gastric acid secretion_Homo sapiens_hsa049711.53082993
33Cocaine addiction_Homo sapiens_hsa050301.52703546
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52620609
35Vibrio cholerae infection_Homo sapiens_hsa051101.51085070
36Oxytocin signaling pathway_Homo sapiens_hsa049211.50023335
37Protein export_Homo sapiens_hsa030601.42138938
38Steroid biosynthesis_Homo sapiens_hsa001001.40804619
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37615923
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33537286
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.30938844
42Parkinsons disease_Homo sapiens_hsa050121.30006556
43Pancreatic secretion_Homo sapiens_hsa049721.27684250
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23121633
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22849671
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21483883
47GnRH signaling pathway_Homo sapiens_hsa049121.19581562
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18370540
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17751581
50Butanoate metabolism_Homo sapiens_hsa006501.16058693
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15570000
52Sphingolipid metabolism_Homo sapiens_hsa006001.15154817
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14405111
54cAMP signaling pathway_Homo sapiens_hsa040241.12121566
55Histidine metabolism_Homo sapiens_hsa003401.10629779
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10452206
57beta-Alanine metabolism_Homo sapiens_hsa004101.10268560
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07775655
59Tyrosine metabolism_Homo sapiens_hsa003501.07428130
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07350320
61Gap junction_Homo sapiens_hsa045401.06318544
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05152557
63Cardiac muscle contraction_Homo sapiens_hsa042601.03261448
64Chemical carcinogenesis_Homo sapiens_hsa052041.02495662
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99144934
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.98815656
67Estrogen signaling pathway_Homo sapiens_hsa049150.98497081
68Phototransduction_Homo sapiens_hsa047440.98348305
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97531157
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95883189
71Mineral absorption_Homo sapiens_hsa049780.95718987
72Fatty acid metabolism_Homo sapiens_hsa012120.93154769
73Tight junction_Homo sapiens_hsa045300.92753983
74Huntingtons disease_Homo sapiens_hsa050160.91414882
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91060893
76Fat digestion and absorption_Homo sapiens_hsa049750.90829796
77Arginine and proline metabolism_Homo sapiens_hsa003300.90228376
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89924574
79Arginine biosynthesis_Homo sapiens_hsa002200.88222108
80AMPK signaling pathway_Homo sapiens_hsa041520.87310987
81Type II diabetes mellitus_Homo sapiens_hsa049300.86709000
82Type I diabetes mellitus_Homo sapiens_hsa049400.86131770
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.85596208
84Melanogenesis_Homo sapiens_hsa049160.83925402
85VEGF signaling pathway_Homo sapiens_hsa043700.82226525
86Peroxisome_Homo sapiens_hsa041460.81331657
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81179371
88Oocyte meiosis_Homo sapiens_hsa041140.78060488
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78032741
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77996647
91Glioma_Homo sapiens_hsa052140.77187051
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77164996
93Glutathione metabolism_Homo sapiens_hsa004800.75813703
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75724289
95African trypanosomiasis_Homo sapiens_hsa051430.75008650
96Alcoholism_Homo sapiens_hsa050340.74953515
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73047069
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71400017
99Fructose and mannose metabolism_Homo sapiens_hsa000510.71346092
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70072596
101Axon guidance_Homo sapiens_hsa043600.68766198
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68275231
103Folate biosynthesis_Homo sapiens_hsa007900.68194711
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68161013
105N-Glycan biosynthesis_Homo sapiens_hsa005100.67547912
106Pyruvate metabolism_Homo sapiens_hsa006200.67375156
107Glucagon signaling pathway_Homo sapiens_hsa049220.66902716
108Thyroid hormone synthesis_Homo sapiens_hsa049180.66078190
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65465311
110Propanoate metabolism_Homo sapiens_hsa006400.63587617
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.63090971
112Bile secretion_Homo sapiens_hsa049760.61367579
113Regulation of autophagy_Homo sapiens_hsa041400.61101183
114Starch and sucrose metabolism_Homo sapiens_hsa005000.61065460
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.60090757
116B cell receptor signaling pathway_Homo sapiens_hsa046620.60086660
117Retinol metabolism_Homo sapiens_hsa008300.58444294
118Fatty acid biosynthesis_Homo sapiens_hsa000610.56931407
119Circadian rhythm_Homo sapiens_hsa047100.56594060
120Choline metabolism in cancer_Homo sapiens_hsa052310.55618950
121Renin-angiotensin system_Homo sapiens_hsa046140.55312693
122ErbB signaling pathway_Homo sapiens_hsa040120.54362987
123Caffeine metabolism_Homo sapiens_hsa002320.53580007
124MAPK signaling pathway_Homo sapiens_hsa040100.51465573
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51356530
126Sulfur relay system_Homo sapiens_hsa041220.50431604
127Fatty acid degradation_Homo sapiens_hsa000710.49131762
128T cell receptor signaling pathway_Homo sapiens_hsa046600.48438970
129Inositol phosphate metabolism_Homo sapiens_hsa005620.46962082
130Ras signaling pathway_Homo sapiens_hsa040140.45814996
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43393851
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42097308
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41815514
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.40562823
135Rheumatoid arthritis_Homo sapiens_hsa053230.39245996
136Colorectal cancer_Homo sapiens_hsa052100.36691802
137Rap1 signaling pathway_Homo sapiens_hsa040150.36599689
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.35440176
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35238879
140Platelet activation_Homo sapiens_hsa046110.34944036
141Primary immunodeficiency_Homo sapiens_hsa053400.34081349
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34036978
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33918144
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32788500
145Wnt signaling pathway_Homo sapiens_hsa043100.31887904
146Shigellosis_Homo sapiens_hsa051310.31532671
147Non-small cell lung cancer_Homo sapiens_hsa052230.31210190
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28500564
149Chemokine signaling pathway_Homo sapiens_hsa040620.27638479
150Insulin signaling pathway_Homo sapiens_hsa049100.27254726
151Prolactin signaling pathway_Homo sapiens_hsa049170.27087419
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26976248

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