TSPAN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.51525584
2L-phenylalanine catabolic process (GO:0006559)6.51525584
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.14899663
4L-phenylalanine metabolic process (GO:0006558)6.14899663
5aromatic amino acid family catabolic process (GO:0009074)5.64810145
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.42125918
7alpha-linolenic acid metabolic process (GO:0036109)5.32507815
8bile acid biosynthetic process (GO:0006699)5.20823276
9glyoxylate metabolic process (GO:0046487)5.08952822
10sulfur amino acid catabolic process (GO:0000098)5.04025876
11indole-containing compound catabolic process (GO:0042436)4.96750891
12indolalkylamine catabolic process (GO:0046218)4.96750891
13tryptophan catabolic process (GO:0006569)4.96750891
14kynurenine metabolic process (GO:0070189)4.81724910
15cysteine metabolic process (GO:0006534)4.77937090
16high-density lipoprotein particle remodeling (GO:0034375)4.73249568
17complement activation, alternative pathway (GO:0006957)4.71452448
18tryptophan metabolic process (GO:0006568)4.70475174
19urea metabolic process (GO:0019627)4.54724780
20urea cycle (GO:0000050)4.54724780
21negative regulation of fibrinolysis (GO:0051918)4.51923627
22regulation of protein activation cascade (GO:2000257)4.49996368
23peptidyl-glutamic acid carboxylation (GO:0017187)4.49105283
24protein carboxylation (GO:0018214)4.49105283
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.47635586
26bile acid metabolic process (GO:0008206)4.43039585
27reverse cholesterol transport (GO:0043691)4.40230908
28cellular glucuronidation (GO:0052695)4.39391170
29regulation of triglyceride catabolic process (GO:0010896)4.38346328
30regulation of cholesterol esterification (GO:0010872)4.36635879
31regulation of fibrinolysis (GO:0051917)4.31814650
32homocysteine metabolic process (GO:0050667)4.28280447
33lysine metabolic process (GO:0006553)4.26178255
34lysine catabolic process (GO:0006554)4.26178255
35amino-acid betaine metabolic process (GO:0006577)4.25413527
36serine family amino acid catabolic process (GO:0009071)4.24960006
37protein-lipid complex remodeling (GO:0034368)4.24364873
38macromolecular complex remodeling (GO:0034367)4.24364873
39plasma lipoprotein particle remodeling (GO:0034369)4.24364873
40regulation of complement activation (GO:0030449)4.23421673
41triglyceride homeostasis (GO:0070328)4.19679565
42acylglycerol homeostasis (GO:0055090)4.19679565
43glucuronate metabolic process (GO:0019585)4.19100512
44uronic acid metabolic process (GO:0006063)4.19100512
45tyrosine metabolic process (GO:0006570)4.16425709
46nitrogen cycle metabolic process (GO:0071941)4.15870670
47positive regulation of fatty acid beta-oxidation (GO:0032000)4.12043007
48alpha-amino acid catabolic process (GO:1901606)4.07133809
49aromatic amino acid family metabolic process (GO:0009072)4.03782737
50coenzyme catabolic process (GO:0009109)3.99618195
51cellular ketone body metabolic process (GO:0046950)3.96562323
52fatty acid beta-oxidation (GO:0006635)3.92157743
53phospholipid efflux (GO:0033700)3.83656884
54plasma lipoprotein particle clearance (GO:0034381)3.83350040
55cellular amino acid catabolic process (GO:0009063)3.82638075
56low-density lipoprotein particle remodeling (GO:0034374)3.82387318
57fatty acid oxidation (GO:0019395)3.82189762
58lipid oxidation (GO:0034440)3.78845420
59ethanol oxidation (GO:0006069)3.77811566
60acetyl-CoA metabolic process (GO:0006084)3.75573068
61positive regulation of fatty acid oxidation (GO:0046321)3.75011965
62positive regulation of lipid catabolic process (GO:0050996)3.69398258
63monocarboxylic acid catabolic process (GO:0072329)3.68115141
64fatty acid catabolic process (GO:0009062)3.66425166
65cholesterol efflux (GO:0033344)3.65337662
66response to nitrosative stress (GO:0051409)3.64555592
67negative regulation of lipase activity (GO:0060192)3.64191288
68phospholipid homeostasis (GO:0055091)3.63309785
69valine metabolic process (GO:0006573)3.63213366
70benzene-containing compound metabolic process (GO:0042537)3.61591805
71short-chain fatty acid metabolic process (GO:0046459)3.60029705
72regulation of cholesterol metabolic process (GO:0090181)3.59469769
73amine catabolic process (GO:0009310)3.59363291
74cellular biogenic amine catabolic process (GO:0042402)3.59363291
75organic acid catabolic process (GO:0016054)3.59342142
76carboxylic acid catabolic process (GO:0046395)3.59342142
77aldehyde catabolic process (GO:0046185)3.58459700
78glutamate metabolic process (GO:0006536)3.58388667
79bile acid and bile salt transport (GO:0015721)3.56830835
80very-low-density lipoprotein particle assembly (GO:0034379)3.53716914
81arginine metabolic process (GO:0006525)3.51928149
82negative regulation of cholesterol transport (GO:0032375)3.51574037
83negative regulation of sterol transport (GO:0032372)3.51574037
84regulation of cardioblast differentiation (GO:0051890)3.50708479
85indolalkylamine metabolic process (GO:0006586)3.50144722
86cellular modified amino acid catabolic process (GO:0042219)3.50128679
87regulation of cholesterol biosynthetic process (GO:0045540)3.49906988
88anterior/posterior axis specification, embryo (GO:0008595)3.48897690
89carnitine metabolic process (GO:0009437)3.48238315
90epoxygenase P450 pathway (GO:0019373)3.46877811
91branched-chain amino acid catabolic process (GO:0009083)3.42079996
92ketone body metabolic process (GO:1902224)3.42020592
93plasma lipoprotein particle assembly (GO:0034377)3.41915154
94regulation of bile acid biosynthetic process (GO:0070857)3.41552878
952-oxoglutarate metabolic process (GO:0006103)3.35552856
96flavonoid metabolic process (GO:0009812)3.35317108
97dicarboxylic acid biosynthetic process (GO:0043650)3.34241550
98serine family amino acid metabolic process (GO:0009069)3.33240852
99cytolysis (GO:0019835)3.31880062
100pyrimidine nucleobase catabolic process (GO:0006208)3.31877942
101plasma lipoprotein particle organization (GO:0071827)3.31704306
102xenobiotic catabolic process (GO:0042178)3.27012231
103negative regulation of hormone biosynthetic process (GO:0032353)3.15677898
104negative regulation of hormone metabolic process (GO:0032351)3.06245580
105NADH metabolic process (GO:0006734)2.85490723
106bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84705877
107ventricular cardiac muscle cell development (GO:0055015)2.84264121
108anterior/posterior axis specification (GO:0009948)2.76136911
109mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74072160
110chromatin remodeling at centromere (GO:0031055)2.73851261
111signal transduction involved in regulation of gene expression (GO:0023019)2.71682726
112somite rostral/caudal axis specification (GO:0032525)2.69329407
113CENP-A containing nucleosome assembly (GO:0034080)2.68806971
114lactate metabolic process (GO:0006089)2.60350033
115cGMP biosynthetic process (GO:0006182)2.59317353
116positive regulation of glycoprotein biosynthetic process (GO:0010560)2.56727176
117regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.53847293
118notochord development (GO:0030903)2.51805413
119glucocorticoid biosynthetic process (GO:0006704)2.51263801
120calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50469903
121paraxial mesoderm development (GO:0048339)2.50097445
122regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.47798283
123endocrine process (GO:0050886)2.47798283
124regulation of systemic arterial blood pressure by hormone (GO:0001990)2.47798283
125nephron tubule formation (GO:0072079)2.47131540
126embryonic axis specification (GO:0000578)2.41622695
127embryonic foregut morphogenesis (GO:0048617)2.40681162
128glomerulus development (GO:0032835)2.38703509
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.36206849
130Leydig cell differentiation (GO:0033327)2.33894511
131tricarboxylic acid cycle (GO:0006099)2.33160793
132angiotensin maturation (GO:0002003)2.29869296
133midgut development (GO:0007494)2.29751472
134drug metabolic process (GO:0017144)2.27045372
135transcytosis (GO:0045056)2.24285075
136positive regulation of glycoprotein metabolic process (GO:1903020)2.24281681
137cell migration involved in gastrulation (GO:0042074)2.21365141
138regulation of steroid hormone biosynthetic process (GO:0090030)2.21123138
139embryonic retina morphogenesis in camera-type eye (GO:0060059)2.18761884
140urate metabolic process (GO:0046415)2.18585538
141regulation of sulfur metabolic process (GO:0042762)2.17934630
142neuron fate determination (GO:0048664)2.17678361
143mesenchymal cell differentiation (GO:0048762)2.17306797
144dorsal/ventral axis specification (GO:0009950)2.17213142
145histone exchange (GO:0043486)2.16986293
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.16287983
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.16287983
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.16287983
149heme transport (GO:0015886)2.15452200
150water-soluble vitamin biosynthetic process (GO:0042364)2.15330460
151hair cell differentiation (GO:0035315)2.14981340
152type B pancreatic cell development (GO:0003323)2.13600449
153vascular smooth muscle contraction (GO:0014829)2.13394253
154primitive streak formation (GO:0090009)2.11552592
155sequestering of extracellular ligand from receptor (GO:0035581)2.11310078
156regulation of meiosis I (GO:0060631)2.09672527
157regulation of glucokinase activity (GO:0033131)2.09439989
158regulation of hexokinase activity (GO:1903299)2.09439989
159regulation of mesoderm development (GO:2000380)2.09299846
160auditory receptor cell differentiation (GO:0042491)2.09052834
161cellular response to nitric oxide (GO:0071732)2.08902644
162embryonic pattern specification (GO:0009880)2.08792784
163intestinal absorption (GO:0050892)2.08278528
164artery smooth muscle contraction (GO:0014824)2.08216041
165gastrulation with mouth forming second (GO:0001702)2.07718736
166protein localization to kinetochore (GO:0034501)2.07534925
167toxin metabolic process (GO:0009404)2.07208764
168chemical homeostasis within a tissue (GO:0048875)2.04889817
169establishment of integrated proviral latency (GO:0075713)2.04785390
170vitamin biosynthetic process (GO:0009110)2.04783329
171chondrocyte proliferation (GO:0035988)2.04312543
172ectodermal placode formation (GO:0060788)2.04256563
1733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.04057136
174purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.04057136
175prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.04048911
176thalamus development (GO:0021794)2.02188893
177gastrulation (GO:0007369)2.01654547
178nodal signaling pathway (GO:0038092)2.00676967
179regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.00643907
180hyperosmotic salinity response (GO:0042538)2.00187767
181positive regulation of actin filament depolymerization (GO:0030836)1.99729820
182receptor guanylyl cyclase signaling pathway (GO:0007168)1.98323926
183surfactant homeostasis (GO:0043129)1.97713556
184phenylpropanoid metabolic process (GO:0009698)1.97711414
185respiratory chain complex IV assembly (GO:0008535)1.96711821
186proteasome assembly (GO:0043248)1.96490402
187regulation of systemic arterial blood pressure (GO:0003073)1.95965270
188endocrine pancreas development (GO:0031018)1.95340053
189cellular response to BMP stimulus (GO:0071773)1.95170124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.47046964
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.71949009
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10701639
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.62885550
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.37434697
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.16987398
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.43954917
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.83913525
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66110604
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25805782
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.92592539
12AR_21909140_ChIP-Seq_LNCAP_Human2.69118194
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54649266
14CLOCK_20551151_ChIP-Seq_293T_Human2.37608117
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33535788
16FUS_26573619_Chip-Seq_HEK293_Human1.94317360
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91489061
18* EWS_26573619_Chip-Seq_HEK293_Human1.85637303
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83943295
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81343706
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.81302597
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72146089
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65308654
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.59369370
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59208677
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.55503026
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.53478592
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47007054
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.45084504
30VDR_22108803_ChIP-Seq_LS180_Human1.42659272
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36296818
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35582728
33HTT_18923047_ChIP-ChIP_STHdh_Human1.35299010
34SMAD3_21741376_ChIP-Seq_HESCs_Human1.32193241
35NANOG_16153702_ChIP-ChIP_HESCs_Human1.31172007
36* PIAS1_25552417_ChIP-Seq_VCAP_Human1.30363478
37* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30167449
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29370299
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29256803
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29159907
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27878696
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25899132
43SMAD4_21799915_ChIP-Seq_A2780_Human1.24707080
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24376565
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24258153
46TCF4_22108803_ChIP-Seq_LS180_Human1.23817143
47CDX2_22108803_ChIP-Seq_LS180_Human1.23095265
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23005106
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22123419
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22123419
51TAF15_26573619_Chip-Seq_HEK293_Human1.21678844
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21266979
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21007264
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.19503630
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17258707
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.16753115
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16231876
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15251581
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.14713038
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13598644
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12315695
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11956681
63TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11856148
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11381347
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10975285
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.10517843
67GATA1_22025678_ChIP-Seq_K562_Human1.10127183
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09877731
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.09376706
70BCAT_22108803_ChIP-Seq_LS180_Human1.07808961
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07786838
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07682857
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07627975
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.07581134
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06475424
76* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05901881
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.05408341
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05389843
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04724463
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04665065
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01238194
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01222845
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.00433232
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00268090
85SOX2_19829295_ChIP-Seq_ESCs_Human0.99997247
86NANOG_19829295_ChIP-Seq_ESCs_Human0.99997247
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99405695
88ELK1_19687146_ChIP-ChIP_HELA_Human0.98981526
89ZNF274_21170338_ChIP-Seq_K562_Hela0.98401111
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98057591
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.98033887
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97999446
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97432784
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97190327
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97110373
96GBX2_23144817_ChIP-Seq_PC3_Human0.96552836
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94051369
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93998914
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93571722
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.93413642
101TCF4_18268006_ChIP-ChIP_LS174T_Human0.93257049
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93095087
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.92358802
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92106388
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92056987
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91929604
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91929604
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91929604
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90831665
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.90315967
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89877699
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86394552
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85301981
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.85175094
115* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84874258
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84047794
117GATA4_25053715_ChIP-Seq_YYC3_Human0.83730151
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83382667
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79866877
120* SOX2_20726797_ChIP-Seq_SW620_Human0.79817217
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79367955
122* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79111826
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79069103
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78963550
125AR_21572438_ChIP-Seq_LNCaP_Human0.78924989
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78529445
127P300_19829295_ChIP-Seq_ESCs_Human0.76548183
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74571268
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.73888230
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72252729
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71745459
132AHR_22903824_ChIP-Seq_MCF-7_Human0.71290736
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.69497909
134CJUN_26792858_Chip-Seq_BT549_Human0.68196027
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67531691
136* FOXA1_25552417_ChIP-Seq_VCAP_Human0.67098222
137* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.66723643
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.66415522
139* TP53_18474530_ChIP-ChIP_U2OS_Human0.66314025
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.64808584
141* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64169492
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.63390814
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.63029597
144* AR_25329375_ChIP-Seq_VCAP_Human0.62500375
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.60706610
146SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.59922812
147* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.59918798
148RXR_22108803_ChIP-Seq_LS180_Human0.59329943
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.58771162
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57701015
151* TP63_23658742_ChIP-Seq_EP156T_Human0.57257920
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.56817576
153* ISL1_27105846_Chip-Seq_CPCs_Mouse0.56614928
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.56503139
155AR_20517297_ChIP-Seq_VCAP_Human0.56222020
156CBP_21632823_ChIP-Seq_H3396_Human0.55389020
157* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.55113727
158SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.52987095
159* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.52780202
160NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52603894
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52161087
162TBX20_22328084_ChIP-Seq_HEART_Mouse0.51857164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.58998952
2MP0005360_urolithiasis6.74045852
3MP0005085_abnormal_gallbladder_physiolo5.80260132
4MP0005365_abnormal_bile_salt5.72553682
5MP0008875_abnormal_xenobiotic_pharmacok4.76372728
6MP0010234_abnormal_vibrissa_follicle3.87542865
7MP0003806_abnormal_nucleotide_metabolis3.67574817
8MP0010329_abnormal_lipoprotein_level3.58821256
9MP0003252_abnormal_bile_duct3.32614244
10MP0003890_abnormal_embryonic-extraembry2.95445084
11MP0003283_abnormal_digestive_organ2.78340641
12MP0005332_abnormal_amino_acid2.74323424
13MP0005670_abnormal_white_adipose2.70043166
14MP0003941_abnormal_skin_development2.46891009
15MP0003195_calcinosis2.45316018
16MP0009840_abnormal_foam_cell2.42937959
17MP0005083_abnormal_biliary_tract2.30246878
18MP0001666_abnormal_nutrient_absorption2.27184390
19MP0002118_abnormal_lipid_homeostasis2.13916928
20MP0003191_abnormal_cellular_cholesterol2.03745798
21MP0010352_gastrointestinal_tract_polyps1.88567777
22MP0004215_abnormal_myocardial_fiber1.88203172
23MP0004019_abnormal_vitamin_homeostasis1.86339832
24MP0000609_abnormal_liver_physiology1.84047352
25MP0003119_abnormal_digestive_system1.83870287
26MP0000462_abnormal_digestive_system1.79357869
27MP0002102_abnormal_ear_morphology1.74058348
28MP0005319_abnormal_enzyme/_coenzyme1.68507584
29MP0002938_white_spotting1.68297309
30MP0009697_abnormal_copulation1.67416551
31MP0001764_abnormal_homeostasis1.64508306
32MP0002138_abnormal_hepatobiliary_system1.63799148
33MP0003718_maternal_effect1.60600468
34MP0002909_abnormal_adrenal_gland1.55711049
35MP0004130_abnormal_muscle_cell1.53201630
36MP0003186_abnormal_redox_activity1.51243389
37MP0010368_abnormal_lymphatic_system1.50362149
38MP0010678_abnormal_skin_adnexa1.49911536
39MP0000516_abnormal_urinary_system1.49111337
40MP0005367_renal/urinary_system_phenotyp1.49111337
41MP0005584_abnormal_enzyme/coenzyme_acti1.46011299
42MP0006072_abnormal_retinal_apoptosis1.42737777
43MP0002837_dystrophic_cardiac_calcinosis1.36642731
44MP0001293_anophthalmia1.34449210
45MP0002233_abnormal_nose_morphology1.33594834
46MP0003567_abnormal_fetal_cardiomyocyte1.33041189
47MP0003868_abnormal_feces_composition1.32939795
48MP0003937_abnormal_limbs/digits/tail_de1.32787508
49MP0005666_abnormal_adipose_tissue1.27259035
50MP0003693_abnormal_embryo_hatching1.24408193
51MP0009643_abnormal_urine_homeostasis1.20987040
52MP0002971_abnormal_brown_adipose1.19116509
53MP0004264_abnormal_extraembryonic_tissu1.18643830
54MP0005647_abnormal_sex_gland1.18298553
55MP0001485_abnormal_pinna_reflex1.18071043
56MP0002876_abnormal_thyroid_physiology1.18020996
57MP0004957_abnormal_blastocyst_morpholog1.17505464
58MP0003011_delayed_dark_adaptation1.16043880
59MP0003705_abnormal_hypodermis_morpholog1.15294283
60MP0008004_abnormal_stomach_pH1.14935239
61MP0009384_cardiac_valve_regurgitation1.13620063
62MP0003137_abnormal_impulse_conducting1.11081092
63MP0008775_abnormal_heart_ventricle1.10348190
64MP0002697_abnormal_eye_size1.07359850
65MP0008932_abnormal_embryonic_tissue1.06676215
66MP0005408_hypopigmentation1.05984924
67MP0003690_abnormal_glial_cell1.05777073
68MP0003136_yellow_coat_color1.03454502
69MP0004085_abnormal_heartbeat1.01805393
70MP0006036_abnormal_mitochondrial_physio1.00910063
71MP0002254_reproductive_system_inflammat1.00628348
72MP0000537_abnormal_urethra_morphology0.98937223
73MP0000013_abnormal_adipose_tissue0.98028139
74MP0004084_abnormal_cardiac_muscle0.97806311
75MP0005535_abnormal_body_temperature0.97711157
76MP0005451_abnormal_body_composition0.97234134
77MP0005334_abnormal_fat_pad0.96631320
78MP0000598_abnormal_liver_morphology0.95434259
79MP0002084_abnormal_developmental_patter0.94399178
80MP0000762_abnormal_tongue_morphology0.92984595
81MP0002127_abnormal_cardiovascular_syste0.92087573
82MP0005248_abnormal_Harderian_gland0.91726385
83MP0001756_abnormal_urination0.90159109
84MP0002078_abnormal_glucose_homeostasis0.89835477
85MP0005084_abnormal_gallbladder_morpholo0.89563055
86MP0002234_abnormal_pharynx_morphology0.89379784
87MP0005395_other_phenotype0.88301096
88MP0004782_abnormal_surfactant_physiolog0.87577475
89MP0006054_spinal_hemorrhage0.84855824
90MP0002090_abnormal_vision0.84154521
91MP0001984_abnormal_olfaction0.84060443
92MP0000049_abnormal_middle_ear0.84050798
93MP0004133_heterotaxia0.83617764
94* MP0001286_abnormal_eye_development0.83537752
95MP0002111_abnormal_tail_morphology0.83308310
96MP0000631_abnormal_neuroendocrine_gland0.82865538
97MP0005376_homeostasis/metabolism_phenot0.82014020
98MP0005187_abnormal_penis_morphology0.81440349
99MP0009053_abnormal_anal_canal0.80535576
100MP0001944_abnormal_pancreas_morphology0.79268865
101MP0005375_adipose_tissue_phenotype0.78480191
102MP0005379_endocrine/exocrine_gland_phen0.77766428
103MP0003935_abnormal_craniofacial_develop0.77341105
104MP0000230_abnormal_systemic_arterial0.77324483
105MP0002163_abnormal_gland_morphology0.77005017
106MP0000534_abnormal_ureter_morphology0.75826427
107MP0005380_embryogenesis_phenotype0.75264595
108MP0001672_abnormal_embryogenesis/_devel0.75264595
109MP0000383_abnormal_hair_follicle0.74793973
110MP0005636_abnormal_mineral_homeostasis0.74272768
111MP0000604_amyloidosis0.73755265
112MP0000538_abnormal_urinary_bladder0.73434206
113MP0004272_abnormal_basement_membrane0.73033091
114MP0002085_abnormal_embryonic_tissue0.73018281
115MP0000566_synostosis0.72410042
116MP0009642_abnormal_blood_homeostasis0.72028785
117MP0009115_abnormal_fat_cell0.71737156
118MP0003755_abnormal_palate_morphology0.71467268
119MP0006138_congestive_heart_failure0.70372108
120MP0005253_abnormal_eye_physiology0.70351899
121MP0000428_abnormal_craniofacial_morphol0.69861171
122MP0005448_abnormal_energy_balance0.69766158
123MP0009764_decreased_sensitivity_to0.69573710
124MP0008789_abnormal_olfactory_epithelium0.69540200
125MP0003984_embryonic_growth_retardation0.68836932
126MP0002088_abnormal_embryonic_growth/wei0.68774856
127MP0001661_extended_life_span0.67458888
128MP0004484_altered_response_of0.67420647
129MP0001664_abnormal_digestion0.67392994
130MP0000749_muscle_degeneration0.67040304
131MP0009763_increased_sensitivity_to0.66981843
132MP0009780_abnormal_chondrocyte_physiolo0.66305663
133MP0008058_abnormal_DNA_repair0.66287958
134MP0005266_abnormal_metabolism0.66031130
135MP0001730_embryonic_growth_arrest0.65728788
136MP0000639_abnormal_adrenal_gland0.64816782
137MP0001879_abnormal_lymphatic_vessel0.61624259
138MP0005220_abnormal_exocrine_pancreas0.61427059
139MP0003656_abnormal_erythrocyte_physiolo0.59238335
140MP0004185_abnormal_adipocyte_glucose0.59100501
141MP0001177_atelectasis0.58403185
142MP0009765_abnormal_xenobiotic_induced0.58337041
143MP0004883_abnormal_blood_vessel0.58315320
144MP0005330_cardiomyopathy0.57196539
145MP0002972_abnormal_cardiac_muscle0.55038409
146MP0003953_abnormal_hormone_level0.54312858
147MP0005595_abnormal_vascular_smooth0.53706635
148MP0010030_abnormal_orbit_morphology0.53688789
149MP0000003_abnormal_adipose_tissue0.53549997
150MP0005164_abnormal_response_to0.51447574
151MP0001544_abnormal_cardiovascular_syste0.51098380
152MP0005385_cardiovascular_system_phenoty0.51098380
153MP0003329_amyloid_beta_deposits0.50582838
154MP0006035_abnormal_mitochondrial_morpho0.49618144
155MP0003959_abnormal_lean_body0.49380411
156MP0002970_abnormal_white_adipose0.48098446
157MP0005620_abnormal_muscle_contractility0.47704163
158MP0002249_abnormal_larynx_morphology0.47373025
159MP0004043_abnormal_pH_regulation0.46653936
160MP0002332_abnormal_exercise_endurance0.42715214
161MP0003942_abnormal_urinary_system0.42658012
162MP0002295_abnormal_pulmonary_circulatio0.42373704
163MP0004147_increased_porphyrin_level0.42022042
164MP0005167_abnormal_blood-brain_barrier0.41724687
165MP0000427_abnormal_hair_cycle0.41430413
166MP0009672_abnormal_birth_weight0.40832365
167MP0008469_abnormal_protein_level0.40465003
168MP0008438_abnormal_cutaneous_collagen0.40292850
169MP0001881_abnormal_mammary_gland0.40209128

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.38114084
2Intrahepatic cholestasis (HP:0001406)6.20817621
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.08499466
4Prolonged partial thromboplastin time (HP:0003645)5.58326639
5Xanthomatosis (HP:0000991)5.53433494
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.30515954
7Hypobetalipoproteinemia (HP:0003563)5.27867359
8Hyperlipoproteinemia (HP:0010980)4.99450179
9Complement deficiency (HP:0004431)4.83737059
10Hyperglycinuria (HP:0003108)4.79545043
11Hyperglycinemia (HP:0002154)4.57651830
12Epidermoid cyst (HP:0200040)4.54494543
13Hypoglycemic coma (HP:0001325)4.50821444
14Abnormality of glycine metabolism (HP:0010895)4.47733536
15Abnormality of serine family amino acid metabolism (HP:0010894)4.47733536
16Hyperammonemia (HP:0001987)4.40850471
17Ketosis (HP:0001946)4.36037288
18Hypolipoproteinemia (HP:0010981)4.33883754
19Hypoalphalipoproteinemia (HP:0003233)4.11712174
20Abnormality of fatty-acid metabolism (HP:0004359)4.07132411
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.04731618
22Joint hemorrhage (HP:0005261)3.89389217
23Hyperactive renin-angiotensin system (HP:0000841)3.82989334
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.76149456
25Abnormality of methionine metabolism (HP:0010901)3.73660578
26Ketoacidosis (HP:0001993)3.71478296
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.68019972
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.64192806
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.58501018
30Abnormality of the common coagulation pathway (HP:0010990)3.54396577
31Fat malabsorption (HP:0002630)3.44143427
32Abnormality of the intrinsic pathway (HP:0010989)3.42971787
33Hypercholesterolemia (HP:0003124)3.33181973
34Double outlet right ventricle (HP:0001719)3.32397350
35Congenital malformation of the right heart (HP:0011723)3.32397350
36Abnormality of complement system (HP:0005339)3.30902473
37Conjugated hyperbilirubinemia (HP:0002908)3.21060919
38Abnormal pancreas size (HP:0012094)3.20649901
39Abnormality of serum amino acid levels (HP:0003112)3.15356250
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97048547
41Dicarboxylic aciduria (HP:0003215)2.97048547
42Delayed CNS myelination (HP:0002188)2.85609226
43Hepatocellular carcinoma (HP:0001402)2.84382028
44Popliteal pterygium (HP:0009756)2.82199801
45Lethargy (HP:0001254)2.79707910
46Abnormality of vitamin B metabolism (HP:0004340)2.77833811
47Cerebral edema (HP:0002181)2.77313615
48Hyperbilirubinemia (HP:0002904)2.76873433
49Hyperaldosteronism (HP:0000859)2.70753549
50Increased circulating renin level (HP:0000848)2.70141829
51Metabolic acidosis (HP:0001942)2.68360173
52Generalized aminoaciduria (HP:0002909)2.67780426
53Abnormality of renin-angiotensin system (HP:0000847)2.64848929
54Abnormality of pyrimidine metabolism (HP:0004353)2.63785493
55Renal cortical cysts (HP:0000803)2.62877194
56Enlarged kidneys (HP:0000105)2.60994820
57Skin nodule (HP:0200036)2.57881540
58Abnormality of the vitamin B12 metabolism (HP:0004341)2.57753686
59Renal salt wasting (HP:0000127)2.56231527
60Hypoglycemic seizures (HP:0002173)2.55040367
61Steatorrhea (HP:0002570)2.54785496
62Metabolic alkalosis (HP:0200114)2.52953704
63Myocardial infarction (HP:0001658)2.52513566
64Abnormality of nucleobase metabolism (HP:0010932)2.50547599
65Right ventricular cardiomyopathy (HP:0011663)2.49452360
66Symptomatic seizures (HP:0011145)2.49345566
67Abnormality of purine metabolism (HP:0004352)2.43928653
68Sensorimotor neuropathy (HP:0007141)2.43374742
69Decreased circulating renin level (HP:0003351)2.42287705
70Congenital sensorineural hearing impairment (HP:0008527)2.39074543
71Gout (HP:0001997)2.35051362
72Proximal tubulopathy (HP:0000114)2.29477586
73Vomiting (HP:0002013)2.27376430
74Brushfield spots (HP:0001088)2.25377261
75Abnormal gallbladder morphology (HP:0012437)2.25016475
76Myoglobinuria (HP:0002913)2.24891432
77Megaloblastic anemia (HP:0001889)2.24573877
78Hyperglycemia (HP:0003074)2.22574931
79Abnormality of glycolysis (HP:0004366)2.22554858
80Increased serum pyruvate (HP:0003542)2.22554858
81Mitral stenosis (HP:0001718)2.21057660
82Hyperinsulinemic hypoglycemia (HP:0000825)2.19038705
83Hypomagnesemia (HP:0002917)2.15551294
84Pancreatic islet-cell hyperplasia (HP:0004510)2.14500463
85Spontaneous abortion (HP:0005268)2.14432735
86Esophageal varix (HP:0002040)2.14172250
87Intestinal atresia (HP:0011100)2.13251750
88Cholelithiasis (HP:0001081)2.08657175
89Abnormality of magnesium homeostasis (HP:0004921)2.07489230
90Hydroxyprolinuria (HP:0003080)2.07145590
91Abnormality of proline metabolism (HP:0010907)2.07145590
92Irritability (HP:0000737)2.06467923
93Hypochromic microcytic anemia (HP:0004840)2.06078653
94Opisthotonus (HP:0002179)2.03194188
95Hypothermia (HP:0002045)2.02644896
96Pancreatitis (HP:0001733)2.02290596
97Spastic diplegia (HP:0001264)2.01835681
98Abnormality of urine glucose concentration (HP:0011016)2.01676074
99Glycosuria (HP:0003076)2.01676074
100Abnormality of chloride homeostasis (HP:0011422)2.01638323
101Hypokalemia (HP:0002900)2.00453834
102Vascular calcification (HP:0004934)2.00084421
103Systemic lupus erythematosus (HP:0002725)1.99826686
104Late onset (HP:0003584)1.99563563
105Hyperphosphaturia (HP:0003109)1.99496840
106Bicornuate uterus (HP:0000813)1.98340162
107Neoplasm of the adrenal gland (HP:0100631)1.96772045
108Nausea (HP:0002018)1.96753838
109Hypertriglyceridemia (HP:0002155)1.96407289
110Neonatal onset (HP:0003623)1.96030559
111Abnormal gallbladder physiology (HP:0012438)1.95954966
112Cholecystitis (HP:0001082)1.95954966
113Hepatic necrosis (HP:0002605)1.92446643
114Hepatoblastoma (HP:0002884)1.91934833
115Abnormal biliary tract morphology (HP:0012440)1.90440982
116Acanthocytosis (HP:0001927)1.89083743
117Ovarian neoplasm (HP:0100615)1.87572316
118Renal hypoplasia (HP:0000089)1.87279917
119Biliary tract neoplasm (HP:0100574)1.84423767
120Abnormality of vitamin metabolism (HP:0100508)1.83804152
121Chronic bronchitis (HP:0004469)1.83177159
122Bifid scrotum (HP:0000048)1.82895358
123Acute encephalopathy (HP:0006846)1.82331489
124Genital tract atresia (HP:0001827)1.81943802
125Hypoplasia of the uterus (HP:0000013)1.81751175
126Respiratory distress (HP:0002098)1.80941391
127Enlarged penis (HP:0000040)1.80788521
128Cardiovascular calcification (HP:0011915)1.80600493
129Abnormality of the gallbladder (HP:0005264)1.80521577
130Amyloidosis (HP:0011034)1.80502250
131Aplasia of the musculature (HP:0100854)1.79996893
132Abnormality of the pancreatic islet cells (HP:0006476)1.78812178
133Abnormality of endocrine pancreas physiology (HP:0012093)1.78812178
134Calf muscle hypertrophy (HP:0008981)1.78386125
135Potter facies (HP:0002009)1.78138069
136Facial shape deformation (HP:0011334)1.78138069
137Hypokalemic alkalosis (HP:0001949)1.77677369
138Abnormal umbilical cord blood vessels (HP:0011403)1.75837563
139Single umbilical artery (HP:0001195)1.75837563
140Abnormality of the fetal cardiovascular system (HP:0010948)1.75837563
141Maternal diabetes (HP:0009800)1.75024033
142Glomerulonephritis (HP:0000099)1.74887748
143Vaginal atresia (HP:0000148)1.74688171
144Labial hypoplasia (HP:0000066)1.74341113
145Hyperuricemia (HP:0002149)1.73733752
146Increased purine levels (HP:0004368)1.73733752
147Abnormal cartilage morphology (HP:0002763)1.73252257
148Short tibia (HP:0005736)1.72089721
149Palpitations (HP:0001962)1.71219452
150Bundle branch block (HP:0011710)1.70902038
151Abnormality of the labia minora (HP:0012880)1.70148349
152Alkalosis (HP:0001948)1.67917650
153Hypoplastic female external genitalia (HP:0012815)1.67494670
154Large for gestational age (HP:0001520)1.67135059
155Sex reversal (HP:0012245)1.67058248
156Abnormal sex determination (HP:0012244)1.67058248
157Hypoplastic labia majora (HP:0000059)1.64467852
158Abnormality of the labia majora (HP:0012881)1.64440566
159Patchy hypopigmentation of hair (HP:0011365)1.63057315
160Aplasia/hypoplasia of the uterus (HP:0008684)1.60943101
161Visceral angiomatosis (HP:0100761)1.57498119
162Gastrointestinal atresia (HP:0002589)1.56384210
163Abnormal urine phosphate concentration (HP:0012599)1.56289945
164Anophthalmia (HP:0000528)1.56042287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.39016145
2SIK13.67451227
3ACVR1B3.35151586
4MST42.95949256
5STK38L2.68703719
6INSRR2.52209676
7ERBB42.49171376
8FGFR42.49030044
9FRK2.49003191
10TNIK2.45413864
11BMPR1B2.37388395
12LMTK22.21518632
13TRIB32.07691473
14BUB12.06377586
15LATS12.03383925
16NEK92.01823743
17SGK22.01373131
18TTK1.99109637
19ERN11.96495509
20TIE11.88925198
21MYLK1.85654898
22CASK1.80136900
23MKNK11.78677177
24OXSR11.78387821
25BRSK21.69857621
26SGK4941.68381997
27SGK2231.68381997
28AKT31.67601603
29EPHB21.65329085
30TRIM281.64265588
31OBSCN1.63090959
32PIK3CG1.62299337
33PLK31.61983952
34MST1R1.57561614
35MAP2K41.56854988
36PRPF4B1.54816926
37SGK31.50875401
38PLK41.49424179
39WEE11.48834655
40PDK41.47813349
41PDK31.47813349
42STK161.43868536
43EPHA21.37413266
44CAMK1D1.35050523
45NEK11.30151277
46EIF2AK31.28154291
47CSNK1G11.27933843
48NLK1.27182268
49PIK3CA1.25787024
50PNCK1.24420247
51FGFR21.22501886
52MAPK151.22075325
53WNK41.17682379
54PRKAA21.16304050
55PKN21.15509067
56PASK1.13339570
57SRPK11.12022061
58DMPK1.08169369
59TSSK61.06051347
60MAP2K11.05178491
61BCR1.05068452
62FER1.04922651
63PINK11.04874565
64STK30.98744899
65PHKG10.98726829
66PHKG20.98726829
67TAOK30.96012299
68EPHA30.95667777
69VRK10.93776276
70KDR0.93737434
71EPHA40.92836177
72PLK10.92490621
73PDK20.91569931
74PAK30.90669940
75MAP3K40.90184293
76ERBB30.90056615
77MAPK110.89409635
78DAPK20.89171418
79BRD40.88494045
80CAMK1G0.86584152
81TGFBR10.86542370
82CSNK1G30.85893369
83MET0.85509270
84GSK3A0.85278440
85NME10.83479803
86TAF10.81716284
87MAP4K20.81629276
88PRKAA10.80953113
89WNK30.80764952
90PTK60.80672532
91FGFR30.79977727
92STK240.79937162
93ZAK0.78496130
94EIF2AK10.75712321
95SIK30.75162664
96CDC70.73821214
97LATS20.71983339
98BRSK10.71670644
99NUAK10.71614766
100PRKACG0.71283727
101CSNK1G20.71071860
102CSNK1A1L0.70811303
103ERBB20.70465641
104LIMK10.70127433
105YES10.68678359
106PRKCZ0.68486995
107STK390.66561604
108VRK20.63896065
109MKNK20.63822364
110ABL20.62511753
111PRKD30.60956903
112IGF1R0.60308569
113CAMK2G0.58866273
114PAK40.58437117
115IRAK10.57859999
116PRKCH0.57320516
117TESK10.56767780
118STK100.56094218
119TGFBR20.55161109
120PLK20.54383755
121IRAK20.53681803
122ROCK20.52923602
123CAMK2D0.52732864
124ROCK10.51085528
125MAPK120.50994132
126PRKG20.50817585
127PRKCG0.47725102
128LRRK20.47545130
129STK40.46239067
130MELK0.45992456
131PRKCE0.45437952
132MAP3K90.44552716
133MAP3K30.43900122
134BMPR20.42870169
135FLT30.42805231
136AURKB0.42462177
137JAK20.42396709
138RPS6KB10.41009751
139MAP2K60.40356906
140EIF2AK20.40192780
141PTK20.39509690
142DYRK20.39244851
143KSR10.38637569
144MAP2K30.38187379
145MAP3K120.37791639
146PDGFRA0.37629643
147AKT20.37561030
148NEK20.37218175
149PBK0.35967710
150GRK70.35262548
151MAPK40.34927746
152PRKACA0.32856943
153FGFR10.31012963
154GRK10.30927565
155MAP2K70.30779938
156CDK60.29852552
157EPHB10.28999590

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.98258880
2Nitrogen metabolism_Homo sapiens_hsa009103.18119171
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01505470
4Fatty acid degradation_Homo sapiens_hsa000712.88598109
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.75175521
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71803304
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71784784
8Propanoate metabolism_Homo sapiens_hsa006402.70333425
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62293576
10Arginine biosynthesis_Homo sapiens_hsa002202.55421903
11Tryptophan metabolism_Homo sapiens_hsa003802.47666930
12Butanoate metabolism_Homo sapiens_hsa006502.36330478
13Complement and coagulation cascades_Homo sapiens_hsa046102.33851161
14Fatty acid metabolism_Homo sapiens_hsa012122.32895665
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24449433
16PPAR signaling pathway_Homo sapiens_hsa033202.24271976
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24009931
18Peroxisome_Homo sapiens_hsa041462.21591688
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16932468
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95285906
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91268715
22Chemical carcinogenesis_Homo sapiens_hsa052041.86625776
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85189211
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.81765657
25beta-Alanine metabolism_Homo sapiens_hsa004101.80699837
26Sulfur metabolism_Homo sapiens_hsa009201.72861484
27Pyruvate metabolism_Homo sapiens_hsa006201.70738532
28Fatty acid elongation_Homo sapiens_hsa000621.64423481
29Retinol metabolism_Homo sapiens_hsa008301.61276718
30Protein export_Homo sapiens_hsa030601.60039539
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53073119
32Caffeine metabolism_Homo sapiens_hsa002321.52402232
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.51275321
34Histidine metabolism_Homo sapiens_hsa003401.48032539
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47420106
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46655937
37Phenylalanine metabolism_Homo sapiens_hsa003601.46421700
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45743929
39Tyrosine metabolism_Homo sapiens_hsa003501.44448700
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42642313
41Carbon metabolism_Homo sapiens_hsa012001.40079856
42Starch and sucrose metabolism_Homo sapiens_hsa005001.33500255
43Bile secretion_Homo sapiens_hsa049761.33387703
44Proteasome_Homo sapiens_hsa030501.24801033
45Steroid biosynthesis_Homo sapiens_hsa001001.24690631
46Selenocompound metabolism_Homo sapiens_hsa004501.22886794
47Staphylococcus aureus infection_Homo sapiens_hsa051501.19868583
48Fat digestion and absorption_Homo sapiens_hsa049751.15932978
49Protein digestion and absorption_Homo sapiens_hsa049741.13708692
50Biosynthesis of amino acids_Homo sapiens_hsa012301.11297960
51Fatty acid biosynthesis_Homo sapiens_hsa000611.08817249
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.06888812
53ABC transporters_Homo sapiens_hsa020101.06632728
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00473987
55Mineral absorption_Homo sapiens_hsa049780.98650350
56Mismatch repair_Homo sapiens_hsa034300.97108117
57Vitamin B6 metabolism_Homo sapiens_hsa007500.93475749
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92085239
59Tight junction_Homo sapiens_hsa045300.88945162
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88533851
61Glycerolipid metabolism_Homo sapiens_hsa005610.83963985
62TGF-beta signaling pathway_Homo sapiens_hsa043500.83646508
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81841189
64Arginine and proline metabolism_Homo sapiens_hsa003300.81484902
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.79785165
66Folate biosynthesis_Homo sapiens_hsa007900.76245791
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73327178
68Sulfur relay system_Homo sapiens_hsa041220.71886530
69Vitamin digestion and absorption_Homo sapiens_hsa049770.69185673
70Glutathione metabolism_Homo sapiens_hsa004800.69105603
71Lysine degradation_Homo sapiens_hsa003100.69100554
72Non-homologous end-joining_Homo sapiens_hsa034500.65220204
73Basal cell carcinoma_Homo sapiens_hsa052170.63676243
74Huntingtons disease_Homo sapiens_hsa050160.59022443
75Cell cycle_Homo sapiens_hsa041100.57629619
76Hippo signaling pathway_Homo sapiens_hsa043900.55482338
77Metabolic pathways_Homo sapiens_hsa011000.50744673
78Cardiac muscle contraction_Homo sapiens_hsa042600.50702249
79Hedgehog signaling pathway_Homo sapiens_hsa043400.47206264
80Adherens junction_Homo sapiens_hsa045200.46674035
81Homologous recombination_Homo sapiens_hsa034400.44728182
82Oocyte meiosis_Homo sapiens_hsa041140.43852962
83Purine metabolism_Homo sapiens_hsa002300.43205208
84Pentose phosphate pathway_Homo sapiens_hsa000300.43093756
85Fanconi anemia pathway_Homo sapiens_hsa034600.42095240
86RNA degradation_Homo sapiens_hsa030180.41585839
87Basal transcription factors_Homo sapiens_hsa030220.41217084
88Prion diseases_Homo sapiens_hsa050200.39828501
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.39555285
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38902380
91Insulin secretion_Homo sapiens_hsa049110.38546070
92Sphingolipid metabolism_Homo sapiens_hsa006000.37920762
93Galactose metabolism_Homo sapiens_hsa000520.36489160
94Insulin resistance_Homo sapiens_hsa049310.34375058
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.33935900
96Glucagon signaling pathway_Homo sapiens_hsa049220.32935799
97Fructose and mannose metabolism_Homo sapiens_hsa000510.31655292
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28986454
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27854485
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25843176
101AMPK signaling pathway_Homo sapiens_hsa041520.21711878
102One carbon pool by folate_Homo sapiens_hsa006700.21532572
103Linoleic acid metabolism_Homo sapiens_hsa005910.21086777
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.13829354
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13123714
106Insulin signaling pathway_Homo sapiens_hsa049100.05959062
107Oxidative phosphorylation_Homo sapiens_hsa001900.05365871
108Ovarian steroidogenesis_Homo sapiens_hsa049130.02748142
109Parkinsons disease_Homo sapiens_hsa050120.00800464
110Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1747564
111Thyroid cancer_Homo sapiens_hsa05216-0.1671591
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1628783
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.1600254
114Renin-angiotensin system_Homo sapiens_hsa04614-0.1409225
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1344455
116Ether lipid metabolism_Homo sapiens_hsa00565-0.1193934
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0682456
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0588686
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0508388
120Alzheimers disease_Homo sapiens_hsa05010-0.0492913
121Circadian rhythm_Homo sapiens_hsa04710-0.0375436
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0227423
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0149041
124Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0099288

Most similar genes based on co-expression Upload to Enrichr

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