TSKS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.79499912
2axonemal dynein complex assembly (GO:0070286)9.59617416
3epithelial cilium movement (GO:0003351)9.51554958
4reproduction (GO:0000003)9.40177115
5motile cilium assembly (GO:0044458)9.37731720
6cilium or flagellum-dependent cell motility (GO:0001539)8.94744055
7regulation of cilium movement (GO:0003352)8.81102994
8cilium movement (GO:0003341)7.78097667
9single fertilization (GO:0007338)7.35335809
10response to pheromone (GO:0019236)7.33586853
11sperm capacitation (GO:0048240)7.32121244
12negative regulation of inclusion body assembly (GO:0090084)7.14554734
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.13788063
14synaptonemal complex organization (GO:0070193)7.05673699
15synaptonemal complex assembly (GO:0007130)6.92382196
16male meiosis (GO:0007140)6.91032669
17rRNA methylation (GO:0031167)6.90164014
18organic cation transport (GO:0015695)6.81751281
19spermatogenesis (GO:0007283)6.77267593
20male gamete generation (GO:0048232)6.74772077
21piRNA metabolic process (GO:0034587)6.61895815
22microtubule depolymerization (GO:0007019)6.47895810
23phosphatidylethanolamine biosynthetic process (GO:0006646)6.37462066
24fertilization (GO:0009566)6.24909224
25gamete generation (GO:0007276)6.20199088
26protein targeting to Golgi (GO:0000042)6.14001719
27regulation of inclusion body assembly (GO:0090083)6.00537046
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.85651032
29phosphatidylethanolamine metabolic process (GO:0046337)5.83879982
30rRNA modification (GO:0000154)5.82820924
31establishment of protein localization to Golgi (GO:0072600)5.80943405
32retrograde transport, vesicle recycling within Golgi (GO:0000301)5.74621331
33calcium ion-dependent exocytosis (GO:0017156)5.68860012
34chromosome condensation (GO:0030261)5.50262315
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.45904282
36germ cell development (GO:0007281)5.43946731
37spermatid nucleus differentiation (GO:0007289)5.27163213
38DNA packaging (GO:0006323)5.25049178
39regulation of microtubule-based movement (GO:0060632)5.19248782
40ventricular system development (GO:0021591)5.18291320
41cell recognition (GO:0008037)5.13388566
42centriole replication (GO:0007099)5.08927453
43positive regulation of Rab GTPase activity (GO:0032851)5.08635379
44regulation of Rab GTPase activity (GO:0032313)5.08635379
45microtubule severing (GO:0051013)5.05198130
46multicellular organismal reproductive process (GO:0048609)4.87833453
47male meiosis I (GO:0007141)4.77359438
48glycerol ether metabolic process (GO:0006662)4.77070474
49centriole assembly (GO:0098534)4.76400948
50chromosome organization involved in meiosis (GO:0070192)4.67287550
51seminiferous tubule development (GO:0072520)4.59686904
52ether metabolic process (GO:0018904)4.40695036
53left/right pattern formation (GO:0060972)4.28262103
54DNA methylation involved in gamete generation (GO:0043046)4.27835776
55histone H3-K9 demethylation (GO:0033169)4.23180647
56protein localization to Golgi apparatus (GO:0034067)4.21316583
57meiotic nuclear division (GO:0007126)4.18324419
58cellular ketone body metabolic process (GO:0046950)4.18044244
59sexual reproduction (GO:0019953)4.14848276
60single strand break repair (GO:0000012)4.13223891
61regulation of transcription involved in cell fate commitment (GO:0060850)4.11485234
62chaperone-mediated protein complex assembly (GO:0051131)4.05245852
63regulation of centriole replication (GO:0046599)3.96635356
64multicellular organismal development (GO:0007275)3.92450367
65response to acidic pH (GO:0010447)3.83493155
66meiosis I (GO:0007127)3.82752692
67protein polyglutamylation (GO:0018095)3.76859007
68regulation of T-helper 2 cell differentiation (GO:0045628)3.76755159
69negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.76294753
70sequestering of actin monomers (GO:0042989)3.75057786
71homeostasis of number of cells within a tissue (GO:0048873)3.63552289
72ketone body metabolic process (GO:1902224)3.62121545
73negative regulation of histone methylation (GO:0031061)3.51215584
74genitalia morphogenesis (GO:0035112)3.48713062
75regulation of spindle checkpoint (GO:0090231)3.47782936
76negative regulation of gene expression, epigenetic (GO:0045814)3.45402021
77peptidyl-threonine dephosphorylation (GO:0035970)3.36252006
78regulation of histone H3-K27 methylation (GO:0061085)3.32983696
79microtubule polymerization or depolymerization (GO:0031109)3.32018091
80cellular response to pH (GO:0071467)3.31969511
81membrane protein intracellular domain proteolysis (GO:0031293)3.29569451
82monoubiquitinated protein deubiquitination (GO:0035520)3.28075823
83protein refolding (GO:0042026)3.26771980
84DNA conformation change (GO:0071103)3.26568303
85amino-acid betaine transport (GO:0015838)3.25744450
86carnitine transport (GO:0015879)3.25744450
87positive regulation of macrophage activation (GO:0043032)3.23722711
88protein K11-linked deubiquitination (GO:0035871)3.23636414
89nucleus organization (GO:0006997)3.20595621
90meiotic cell cycle (GO:0051321)3.20399020
91multicellular organismal movement (GO:0050879)3.18876154
92musculoskeletal movement (GO:0050881)3.18876154
93protein localization to cilium (GO:0061512)3.18799900
94RNA localization (GO:0006403)3.18011970
95cerebral cortex neuron differentiation (GO:0021895)3.17015904
96interferon-gamma secretion (GO:0072643)3.16556635
97nuclear pore complex assembly (GO:0051292)3.13374071
98negative regulation of Rho protein signal transduction (GO:0035024)3.13277427
99coenzyme catabolic process (GO:0009109)3.12257181
100RNA destabilization (GO:0050779)3.09118583
101carnitine transmembrane transport (GO:1902603)3.07969798
102regulation of ARF GTPase activity (GO:0032312)3.06494427
103glycolytic process (GO:0006096)3.01297196
104regulation of interleukin-13 production (GO:0032656)3.00474391
105microtubule nucleation (GO:0007020)2.96363764
106mitotic sister chromatid cohesion (GO:0007064)2.94570347
107protein depolymerization (GO:0051261)2.92744885
108polyamine biosynthetic process (GO:0006596)2.92535504
109negative regulation of granulocyte differentiation (GO:0030853)2.89027577
110cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.87252511
111peptide catabolic process (GO:0043171)2.87230028
112regulation of retinoic acid receptor signaling pathway (GO:0048385)2.86905916
113regulation of phosphoprotein phosphatase activity (GO:0043666)2.82723107
114polyol catabolic process (GO:0046174)2.81151254
115histone H4 deacetylation (GO:0070933)2.79382199
116nucleoside diphosphate phosphorylation (GO:0006165)2.79272504
117cilium organization (GO:0044782)2.77628824
118meiotic cell cycle process (GO:1903046)2.75951169
119microtubule-based movement (GO:0007018)2.70010910
120synapsis (GO:0007129)2.69583570
121alditol metabolic process (GO:0019400)2.68983662
122positive regulation of type 2 immune response (GO:0002830)2.68164730
123chromatin silencing (GO:0006342)2.67782992
124cilium assembly (GO:0042384)2.65682741
125regulation of cilium assembly (GO:1902017)2.64828284
126cellular component assembly involved in morphogenesis (GO:0010927)2.64086438
127axoneme assembly (GO:0035082)2.63499017
128cilium morphogenesis (GO:0060271)2.60646714
129negative regulation of organelle assembly (GO:1902116)2.59085290
130peptidyl-glutamic acid modification (GO:0018200)2.57422545
131intraciliary transport (GO:0042073)2.56560396
132mitochondrion degradation (GO:0000422)2.52485963
133GTP biosynthetic process (GO:0006183)2.43314018
134protein-DNA complex disassembly (GO:0032986)2.41162349
135nucleosome disassembly (GO:0006337)2.41162349
136lactate metabolic process (GO:0006089)2.39574523
137sperm motility (GO:0030317)13.8135419
138cell wall macromolecule catabolic process (GO:0016998)13.6716450
139cell wall macromolecule metabolic process (GO:0044036)13.6716450
140fusion of sperm to egg plasma membrane (GO:0007342)13.3049557
141acrosome reaction (GO:0007340)12.4622809
142sperm-egg recognition (GO:0035036)11.8277317
143acrosome assembly (GO:0001675)11.6302391
144multicellular organism reproduction (GO:0032504)10.9027106
145binding of sperm to zona pellucida (GO:0007339)10.6395853
146cell-cell recognition (GO:0009988)10.5938575
147plasma membrane fusion (GO:0045026)10.1309439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.41131034
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.73365727
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.69374328
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94594500
5EZH2_22144423_ChIP-Seq_EOC_Human3.86502444
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.78564168
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04373244
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99212772
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94778416
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83482338
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.51965386
12VDR_22108803_ChIP-Seq_LS180_Human2.42917322
13LXR_22292898_ChIP-Seq_THP-1_Human2.42555164
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35432793
15BCL6_27268052_Chip-Seq_Bcells_Human2.29052952
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.27384133
17P68_20966046_ChIP-Seq_HELA_Human2.22543822
18RAC3_21632823_ChIP-Seq_H3396_Human2.18963352
19SMC4_20622854_ChIP-Seq_HELA_Human2.11563320
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08097497
21E2F1_20622854_ChIP-Seq_HELA_Human2.07465462
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.06264875
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.03789137
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.03136662
25ERA_21632823_ChIP-Seq_H3396_Human2.02355500
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01160664
27ZNF274_21170338_ChIP-Seq_K562_Hela1.97474864
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94227803
29CTCF_27219007_Chip-Seq_Bcells_Human1.88944602
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.83358253
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83012931
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82332619
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82222338
34RUNX_20019798_ChIP-Seq_JUKART_Human1.81303572
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.78231495
36P300_27268052_Chip-Seq_Bcells_Human1.75809379
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71914800
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71349744
39GATA1_19941826_ChIP-Seq_K562_Human1.70762600
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.66138236
41MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64954333
42* TP63_22573176_ChIP-Seq_HFKS_Human1.64052136
43* STAT1_17558387_ChIP-Seq_HELA_Human1.63902163
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.63137557
45GATA3_21867929_ChIP-Seq_CD8_Mouse1.62811573
46OCT4_20526341_ChIP-Seq_ESCs_Human1.58850805
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58671310
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56802894
49SPI1_23127762_ChIP-Seq_K562_Human1.55472748
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53404581
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.52524040
52SA1_27219007_Chip-Seq_Bcells_Human1.51919117
53TAF2_19829295_ChIP-Seq_ESCs_Human1.50674632
54FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49390456
55MYC_19829295_ChIP-Seq_ESCs_Human1.47218822
56DROSHA_22980978_ChIP-Seq_HELA_Human1.44245654
57CBP_20019798_ChIP-Seq_JUKART_Human1.43573427
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43573427
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42756546
60KDM2B_26808549_Chip-Seq_REH_Human1.41177006
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40156462
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.39786575
63LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39387667
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39192703
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36869789
66P53_21459846_ChIP-Seq_SAOS-2_Human1.36711319
67SPI1_20517297_ChIP-Seq_HL60_Human1.36087455
68* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.35661926
69CTCF_21964334_Chip-Seq_Bcells_Human1.35521294
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35086088
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35078426
72RBPJ_21746931_ChIP-Seq_IB4_Human1.34963300
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34280063
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33921564
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.32743538
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.31253104
77* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31175870
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.31018891
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29471376
80REST_21632747_ChIP-Seq_MESCs_Mouse1.28563854
81GATA3_21867929_ChIP-Seq_TH1_Mouse1.27894733
82OCT4_19829295_ChIP-Seq_ESCs_Human1.24941468
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24575367
84GF1_26923725_Chip-Seq_HPCs_Mouse1.24240768
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.24116404
86ETV1_20927104_ChIP-Seq_GIST48_Human1.24052572
87NCOR1_26117541_ChIP-Seq_K562_Human1.23699016
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.23639344
89MAF_26560356_Chip-Seq_TH2_Human1.22806108
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22565248
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22193448
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21942528
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21763637
94KDM2B_26808549_Chip-Seq_DND41_Human1.21353467
95TCF7_22412390_ChIP-Seq_EML_Mouse1.19650942
96SPI1_26923725_Chip-Seq_HPCs_Mouse1.19522377
97CEBPB_22108803_ChIP-Seq_LS180_Human1.18962286
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.17822909
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17559274
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17419842
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17175701
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17078981
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16371233
104STAT1_20625510_ChIP-Seq_HELA_Human1.16121667
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15940203
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14068675
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13383393
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13022675
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.12555380
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11998347
111GATA6_21074721_ChIP-Seq_CACO-2_Human1.11652681
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.11153670
113VDR_24787735_ChIP-Seq_THP-1_Human1.11142410
114RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11045599
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10977992
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.10651065
117MYB_26560356_Chip-Seq_TH2_Human1.10431153
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09675159
119ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09567152
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09543385
121GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09375455
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08831344
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08831344
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.08207146
125SMRT_27268052_Chip-Seq_Bcells_Human1.07772700
126MYC_27129775_Chip-Seq_CORNEA_Mouse1.07087912
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07066631
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06946364
129ERG_20517297_ChIP-Seq_VCAP_Human1.06917429
130GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06724594
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06480277
132ESET_19884257_ChIP-Seq_ESCs_Mouse1.06294765
133CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05959683
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05714918
135PHF8_20622853_ChIP-Seq_HELA_Human1.04595712
136SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04435669
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.03979203
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.03829635
139* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03585451
140BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.03447801
141KLF4_19829295_ChIP-Seq_ESCs_Human1.03406093
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02636773
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02434078
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02360147
145KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01761409
146CTCF_20526341_ChIP-Seq_ESCs_Human1.00978411
147LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00707974
148UTX_26944678_Chip-Seq_JUKART_Human1.00680237
149NANOG_18555785_Chip-Seq_ESCs_Mouse1.00289217
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99878114
151VDR_24763502_ChIP-Seq_THP-1_Human0.99029100
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96914418
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96639165
154SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95764855
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.95316559
156FLI1_21867929_ChIP-Seq_CD8_Mouse0.94831125
157BCOR_27268052_Chip-Seq_Bcells_Human0.93156855
158KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92110824
159P53_22387025_ChIP-Seq_ESCs_Mouse0.90125793
160NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89771559
161STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88334090
162NANOG_20526341_ChIP-Seq_ESCs_Human0.88298120
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87839066
164* ELF1_20517297_ChIP-Seq_JURKAT_Human0.87831930
165NFYB_21822215_ChIP-Seq_K562_Human0.87421238
166PHF8_20622854_ChIP-Seq_HELA_Human0.87142545
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.86933628
168KLF4_18555785_Chip-Seq_ESCs_Mouse0.86932549
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85690463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04139696
2MP0001929_abnormal_gametogenesis5.50092640
3MP0008877_abnormal_DNA_methylation3.85508016
4MP0002210_abnormal_sex_determination3.31701071
5MP0002161_abnormal_fertility/fecundity3.29454823
6MP0005670_abnormal_white_adipose3.00778953
7MP0001348_abnormal_lacrimal_gland2.99396996
8MP0000678_abnormal_parathyroid_gland2.89765188
9MP0001145_abnormal_male_reproductive2.84668040
10MP0005451_abnormal_body_composition2.70239535
11MP0000653_abnormal_sex_gland2.46196920
12MP0002653_abnormal_ependyma_morphology2.42736430
13MP0003718_maternal_effect2.12502362
14MP0004510_myositis2.00382792
15MP0005410_abnormal_fertilization16.6284643
16MP0005310_abnormal_salivary_gland1.83444978
17MP0003646_muscle_fatigue1.71235325
18MP0002160_abnormal_reproductive_system1.67394441
19MP0004233_abnormal_muscle_weight1.65838346
20MP0005379_endocrine/exocrine_gland_phen1.47746642
21MP0005623_abnormal_meninges_morphology1.43554288
22MP0002127_abnormal_cardiovascular_syste1.34198286
23MP0002249_abnormal_larynx_morphology1.26649777
24MP0005423_abnormal_somatic_nervous1.25902702
25MP0003436_decreased_susceptibility_to1.22344803
26MP0004084_abnormal_cardiac_muscle1.15903366
27MP0002282_abnormal_trachea_morphology1.14470837
28MP0003172_abnormal_lysosome_physiology1.13033333
29MP0002138_abnormal_hepatobiliary_system1.12910595
30MP0001765_abnormal_ion_homeostasis1.05749753
31MP0001984_abnormal_olfaction1.05167535
32MP0001835_abnormal_antigen_presentation1.04116675
33MP0003828_pulmonary_edema1.02954585
34MP0001485_abnormal_pinna_reflex1.01505781
35MP0002822_catalepsy0.95735982
36MP0003077_abnormal_cell_cycle0.93454933
37MP0002419_abnormal_innate_immunity0.93246238
38MP0000681_abnormal_thyroid_gland0.92225923
39MP0002234_abnormal_pharynx_morphology0.89791758
40MP0009046_muscle_twitch0.88426754
41MP0008058_abnormal_DNA_repair0.84948035
42MP0004957_abnormal_blastocyst_morpholog0.84236928
43MP0005389_reproductive_system_phenotype0.83907849
44MP0005083_abnormal_biliary_tract0.83506767
45MP0005647_abnormal_sex_gland0.82852300
46MP0005395_other_phenotype0.81822209
47MP0005025_abnormal_response_to0.81156419
48MP0008004_abnormal_stomach_pH0.81082281
49MP0003115_abnormal_respiratory_system0.75990402
50MP0002723_abnormal_immune_serum0.75897476
51MP0009785_altered_susceptibility_to0.71647915
52MP0001800_abnormal_humoral_immune0.71542686
53MP0003303_peritoneal_inflammation0.71188399
54MP0008995_early_reproductive_senescence0.69623468
55MP0000703_abnormal_thymus_morphology0.69053257
56MP0005377_hearing/vestibular/ear_phenot0.68052392
57MP0003878_abnormal_ear_physiology0.68052392
58MP0002452_abnormal_antigen_presenting0.67918925
59MP0005000_abnormal_immune_tolerance0.67586423
60MP0001486_abnormal_startle_reflex0.67212661
61MP0001963_abnormal_hearing_physiology0.65913142
62MP0003137_abnormal_impulse_conducting0.63950137
63MP0003693_abnormal_embryo_hatching0.62989974
64MP0002722_abnormal_immune_system0.62551107
65MP0002398_abnormal_bone_marrow0.61790559
66MP0009053_abnormal_anal_canal0.60285821
67MP0002837_dystrophic_cardiac_calcinosis0.60037317
68MP0005666_abnormal_adipose_tissue0.59601281
69MP0003011_delayed_dark_adaptation0.59455812
70MP0004085_abnormal_heartbeat0.58322440
71MP0004947_skin_inflammation0.57917728
72MP0005636_abnormal_mineral_homeostasis0.57441551
73MP0002420_abnormal_adaptive_immunity0.57355907
74MP0001873_stomach_inflammation0.57004763
75MP0001819_abnormal_immune_cell0.56810230
76MP0005535_abnormal_body_temperature0.55303493
77MP0008569_lethality_at_weaning0.55274029
78MP0009333_abnormal_splenocyte_physiolog0.55196769
79MP0002735_abnormal_chemical_nociception0.54866757
80MP0000685_abnormal_immune_system0.52824710
81MP0001293_anophthalmia0.51740653
82MP0002269_muscular_atrophy0.51587904
83MP0005671_abnormal_response_to0.51414616
84MP0002998_abnormal_bone_remodeling0.50680414
85MP0003699_abnormal_female_reproductive0.49830599
86MP0010094_abnormal_chromosome_stability0.49688389
87MP0001324_abnormal_eye_pigmentation0.49551344
88MP0000358_abnormal_cell_content/0.49102821
89MP0004036_abnormal_muscle_relaxation0.49070633
90MP0003329_amyloid_beta_deposits0.48968325
91MP0001533_abnormal_skeleton_physiology0.48536100
92MP0000249_abnormal_blood_vessel0.48232966
93MP0000716_abnormal_immune_system0.48221937
94MP0005166_decreased_susceptibility_to0.47565311
95MP0000003_abnormal_adipose_tissue0.47313459
96MP0009764_decreased_sensitivity_to0.47226771
97MP0006036_abnormal_mitochondrial_physio0.46200846
98MP0001764_abnormal_homeostasis0.45475397
99MP0009697_abnormal_copulation0.45186506
100MP0001790_abnormal_immune_system0.44087037
101MP0005387_immune_system_phenotype0.44087037
102MP0005397_hematopoietic_system_phenotyp0.42788708
103MP0001545_abnormal_hematopoietic_system0.42788708
104MP0009278_abnormal_bone_marrow0.42710035
105MP0003950_abnormal_plasma_membrane0.41895668
106MP0000534_abnormal_ureter_morphology0.40523607
107MP0002928_abnormal_bile_duct0.40491571
108MP0003111_abnormal_nucleus_morphology0.40231558
109MP0002102_abnormal_ear_morphology0.38838020
110MP0009115_abnormal_fat_cell0.38150092
111MP0004133_heterotaxia0.35918495
112MP0005253_abnormal_eye_physiology0.35612293
113MP0002736_abnormal_nociception_after0.32933202
114MP0005551_abnormal_eye_electrophysiolog0.32521842
115MP0001730_embryonic_growth_arrest0.31975196
116MP0000569_abnormal_digit_pigmentation0.30835356
117MP0003942_abnormal_urinary_system0.30180157
118MP0005391_vision/eye_phenotype0.30046864
119MP0004811_abnormal_neuron_physiology0.29231373
120MP0003879_abnormal_hair_cell0.29228482
121MP0002971_abnormal_brown_adipose0.28723197
122MP0003633_abnormal_nervous_system0.27079774
123MP0003861_abnormal_nervous_system0.26143578
124MP0001119_abnormal_female_reproductive0.25719700
125MP0006035_abnormal_mitochondrial_morpho0.25236267
126MP0003787_abnormal_imprinting0.23745652
127MP0001661_extended_life_span0.23555818
128MP0003786_premature_aging0.22457028
129MP0002169_no_abnormal_phenotype0.22428905
130MP0002152_abnormal_brain_morphology0.22392066
131MP0004019_abnormal_vitamin_homeostasis0.22360934
132MP0002873_normal_phenotype0.22169765
133MP0003948_abnormal_gas_homeostasis0.22044277
134MP0000604_amyloidosis0.21962200
135MP0008961_abnormal_basal_metabolism0.21732506
136MP0003631_nervous_system_phenotype0.20644166
137MP0002295_abnormal_pulmonary_circulatio0.19929460
138MP0001849_ear_inflammation0.19907243
139MP0010307_abnormal_tumor_latency0.19738537
140MP0002092_abnormal_eye_morphology0.18983793
141MP0002084_abnormal_developmental_patter0.18859231
142MP0005375_adipose_tissue_phenotype0.17810877
143MP0000313_abnormal_cell_death0.17720702
144MP0002139_abnormal_hepatobiliary_system0.17682933
145MP0004742_abnormal_vestibular_system0.16875682
146MP0003959_abnormal_lean_body0.16555282
147MP0008007_abnormal_cellular_replicative0.15756797
148MP0001968_abnormal_touch/_nociception0.15346571
149MP0000751_myopathy0.14868159
150MP0005380_embryogenesis_phenotype0.14818743
151MP0001672_abnormal_embryogenesis/_devel0.14818743
152MP0000001_mammalian_phenotype0.14090774
153MP0001697_abnormal_embryo_size0.14059317
154MP0001727_abnormal_embryo_implantation0.13924718
155MP0004145_abnormal_muscle_electrophysio0.13913772
156MP0002132_abnormal_respiratory_system0.13122588
157MP0002405_respiratory_system_inflammati0.13119510
158MP0008057_abnormal_DNA_replication0.12775135
159MP0004270_analgesia0.12717222
160MP0008875_abnormal_xenobiotic_pharmacok0.12475337
161MP0002229_neurodegeneration0.12450053
162MP0005319_abnormal_enzyme/_coenzyme0.12187011

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.19224276
2Abnormal respiratory motile cilium morphology (HP:0005938)9.09369660
3Abnormal respiratory epithelium morphology (HP:0012253)9.09369660
4Severe visual impairment (HP:0001141)8.34240959
5Rhinitis (HP:0012384)7.49605169
6Chronic bronchitis (HP:0004469)7.21112040
7Abnormal ciliary motility (HP:0012262)7.19083005
8Infertility (HP:0000789)7.00887699
9Nasal polyposis (HP:0100582)6.51360866
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.51357857
11Abnormality of the nasal mucosa (HP:0000433)5.35491684
12Resting tremor (HP:0002322)5.07662251
13Male infertility (HP:0003251)5.02666075
14Bronchitis (HP:0012387)4.60316248
15Bony spicule pigmentary retinopathy (HP:0007737)4.51267084
16Bronchiectasis (HP:0002110)4.45090354
17Attenuation of retinal blood vessels (HP:0007843)4.41683084
18Nephronophthisis (HP:0000090)4.24010740
19Abnormal spermatogenesis (HP:0008669)3.94499498
20Aplasia/Hypoplasia of the earlobes (HP:0009906)3.80084785
21Hyperkalemia (HP:0002153)3.74145781
22Cone-rod dystrophy (HP:0000548)3.63329212
23Abnormal rod and cone electroretinograms (HP:0008323)3.56555635
24Hypoplasia of the thymus (HP:0000778)3.36139958
25Chronic hepatic failure (HP:0100626)3.34756453
26Abnormality of macular pigmentation (HP:0008002)3.31884805
27Recurrent otitis media (HP:0000403)3.30274238
28Hypoplastic ischia (HP:0003175)3.28840995
29Enlarged epiphyses (HP:0010580)3.26050891
30Postural instability (HP:0002172)3.23741439
31Recurrent sinusitis (HP:0011108)3.16480318
32Abnormality of the renal medulla (HP:0100957)3.16278937
33Facial shape deformation (HP:0011334)3.10205561
34Potter facies (HP:0002009)3.10205561
35Ventricular tachycardia (HP:0004756)3.03157654
36Hypoalphalipoproteinemia (HP:0003233)2.99702260
37Generalized aminoaciduria (HP:0002909)2.97835356
38Impulsivity (HP:0100710)2.93003925
39Recurrent bronchitis (HP:0002837)2.86452387
40Abnormality of the ischium (HP:0003174)2.74245705
41Abnormality of dental color (HP:0011073)2.71781918
42Tubular atrophy (HP:0000092)2.71492412
43Tubulointerstitial nephritis (HP:0001970)2.69706875
44Abnormality of the costochondral junction (HP:0000919)2.65078789
45Abnormality of midbrain morphology (HP:0002418)2.65042766
46Molar tooth sign on MRI (HP:0002419)2.65042766
47Progressive sensorineural hearing impairment (HP:0000408)2.64331367
48Truncal obesity (HP:0001956)2.60892094
49Azoospermia (HP:0000027)2.59215967
50Unilateral renal agenesis (HP:0000122)2.58727884
51Cholecystitis (HP:0001082)2.55386069
52Abnormal gallbladder physiology (HP:0012438)2.55386069
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.54712469
54Medial flaring of the eyebrow (HP:0010747)2.53989039
55Bowel incontinence (HP:0002607)2.52446929
56Peripheral hypomyelination (HP:0007182)2.51333606
57Abnormality of the aortic arch (HP:0012303)2.49438589
58Tubulointerstitial abnormality (HP:0001969)2.47210232
59Amelogenesis imperfecta (HP:0000705)2.45030046
60Hyperthyroidism (HP:0000836)2.44960954
61Hypoparathyroidism (HP:0000829)2.44643444
62Truncus arteriosus (HP:0001660)2.43250214
63Abnormal large intestine physiology (HP:0012700)2.40385720
64Menstrual irregularities (HP:0000858)2.39812206
65Gingivitis (HP:0000230)2.34931496
66Aplasia/Hypoplasia of the thymus (HP:0010515)2.32380749
67Osteomalacia (HP:0002749)2.32370102
68Atelectasis (HP:0100750)2.30094839
69Recurrent pneumonia (HP:0006532)2.29197634
70Insulin-resistant diabetes mellitus (HP:0000831)2.27788911
71Upper limb muscle weakness (HP:0003484)2.27503831
72Tetany (HP:0001281)2.26133192
73Chronic obstructive pulmonary disease (HP:0006510)2.24382975
74Obstructive lung disease (HP:0006536)2.24382975
75Portal hypertension (HP:0001409)2.23426720
76Seborrheic dermatitis (HP:0001051)2.23104313
77Dyschromatopsia (HP:0007641)2.21513898
78Gonadotropin excess (HP:0000837)2.18695759
79Tubulointerstitial fibrosis (HP:0005576)2.12916321
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09045215
81Abnormality of the hepatic vasculature (HP:0006707)2.08531574
82Progressive hearing impairment (HP:0001730)2.07329943
83Hyponatremia (HP:0002902)2.04752296
84Progressive cerebellar ataxia (HP:0002073)2.03606839
85Choroideremia (HP:0001139)2.03237505
86Dynein arm defect of respiratory motile cilia (HP:0012255)13.1040156
87Absent/shortened dynein arms (HP:0200106)13.1040156
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0204811
89Abnormality of the parathyroid morphology (HP:0011766)1.99811034
90Abnormality of macrophages (HP:0004311)1.99331489
91Decreased central vision (HP:0007663)1.97963575
92Spastic tetraparesis (HP:0001285)1.97589583
93Abnormality of potassium homeostasis (HP:0011042)1.97139731
94Slow saccadic eye movements (HP:0000514)1.94066970
95Gastrointestinal infarctions (HP:0005244)1.92905448
96Widely patent fontanelles and sutures (HP:0004492)1.92892221
97Hypertensive crisis (HP:0100735)1.91395271
98Abnormal drinking behavior (HP:0030082)1.88669008
99Polydipsia (HP:0001959)1.88669008
100Epiphyseal dysplasia (HP:0002656)1.88071482
101Flattened epiphyses (HP:0003071)1.88062612
102Hypertriglyceridemia (HP:0002155)1.85523444
103Abnormality of lateral ventricle (HP:0030047)1.84393167
104Spastic paraparesis (HP:0002313)1.82479304
105Heterotopia (HP:0002282)1.80519560
106Postaxial foot polydactyly (HP:0001830)1.80471461
107Renovascular hypertension (HP:0100817)1.80455663
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79712890
109Reticulocytosis (HP:0001923)1.79222569
110Protuberant abdomen (HP:0001538)1.78536570
111Hypergonadotropic hypogonadism (HP:0000815)1.77970004
112Transposition of the great arteries (HP:0001669)1.77086384
113Abnormal connection of the cardiac segments (HP:0011545)1.77086384
114Abnormal ventriculo-arterial connection (HP:0011563)1.77086384
115Hypophosphatemic rickets (HP:0004912)1.76805800
116Stage 5 chronic kidney disease (HP:0003774)1.75475176
117Congenital malformation of the right heart (HP:0011723)1.72811119
118Double outlet right ventricle (HP:0001719)1.72811119
119Congenital hepatic fibrosis (HP:0002612)1.72585849
120Hemorrhage of the eye (HP:0011885)1.71808736
121Abnormality of renal excretion (HP:0011036)1.67484750
122Bile duct proliferation (HP:0001408)1.64837957
123Abnormal biliary tract physiology (HP:0012439)1.64837957
124Short ribs (HP:0000773)1.61657518
125Abnormality of the renal cortex (HP:0011035)1.60979487
126Neurofibrillary tangles (HP:0002185)1.58033634
127Aplasia/Hypoplasia of the lens (HP:0008063)1.54492078
128Bell-shaped thorax (HP:0001591)1.54317690
129Oculomotor apraxia (HP:0000657)1.54192992
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.51219559
131Renal dysplasia (HP:0000110)1.49464654
132Postaxial hand polydactyly (HP:0001162)1.46098365
133Asymmetric septal hypertrophy (HP:0001670)1.44713708
134Easy fatigability (HP:0003388)1.43330436
135Abnormal urine output (HP:0012590)1.42792306
136Facial cleft (HP:0002006)1.42675450
137Absent epiphyses (HP:0010577)1.40747602
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40747602
139Bundle branch block (HP:0011710)1.39670110
140Abnormality of the neuromuscular junction (HP:0003398)1.38478958
141Fatigable weakness (HP:0003473)1.38478958
142Abnormality of the lower motor neuron (HP:0002366)1.38063648
143Abnormality of the dental root (HP:0006486)1.38053664
144Taurodontia (HP:0000679)1.38053664
145Abnormality of permanent molar morphology (HP:0011071)1.38053664
146Chronic sinusitis (HP:0011109)1.35847318
147Abnormality of saccadic eye movements (HP:0000570)1.34795343
148Congenital primary aphakia (HP:0007707)1.33993907
149Gait imbalance (HP:0002141)1.33539274
150Deformed sella turcica (HP:0002681)1.33530549
151Cerebellar dysplasia (HP:0007033)1.32929793
152Fibular hypoplasia (HP:0003038)1.32564323
153Abnormality of dentin (HP:0010299)1.31176819
154Cerebral inclusion bodies (HP:0100314)1.30751707
155Cystic liver disease (HP:0006706)1.30438218
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29712637
157Hemiparesis (HP:0001269)1.29248556
158Sensory axonal neuropathy (HP:0003390)1.28242129
159Abnormality of the dental pulp (HP:0006479)1.27795012
160Abnormality of molar (HP:0011077)1.27505038
161Abnormality of molar morphology (HP:0011070)1.27505038
162Loss of speech (HP:0002371)1.26999403
163Exercise-induced myalgia (HP:0003738)1.26073231
164Pancreatic fibrosis (HP:0100732)1.24054985
165Myoglobinuria (HP:0002913)1.23102805
166Abnormality of ocular smooth pursuit (HP:0000617)1.22813958
167Microglossia (HP:0000171)1.20282980
168Hypercholesterolemia (HP:0003124)1.20193800
169Polyuria (HP:0000103)1.19266658
170Amyotrophic lateral sclerosis (HP:0007354)1.18690280
171Broad distal phalanx of finger (HP:0009836)1.18574179
172Short femoral neck (HP:0100864)1.18182868
173Nephropathy (HP:0000112)1.18015015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.60630800
2PDK47.60630800
3TESK17.11475520
4PRKD35.59706269
5PDK24.91480177
6ICK4.82472803
7DDR24.18073064
8BRD43.26295991
9INSRR2.97954091
10PTK2B2.38420191
11MAP4K22.20048487
12PLK22.16133497
13KSR22.15928919
14STK382.10170668
15WNK42.09761328
16STK391.99831577
17PNCK1.80975859
18PIK3CG1.76744630
19NEK21.70027262
20DYRK1B1.64230731
21BLK1.47404443
22CDK71.28992014
23PDK11.23777669
24JAK31.13423419
25MAP3K21.08300936
26LATS21.08290449
27MAP3K81.07454942
28MAP4K11.03454395
29MST1R0.96472099
30DYRK30.94403921
31MAP3K110.94386112
32TYRO30.93887477
33MAP3K10.93742476
34PRPF4B0.91412885
35MAP3K130.88445484
36MAP3K90.86575976
37MAPK150.86020535
38CAMK1D0.84650868
39PDPK10.82750726
40RPS6KA20.80055142
41SIK20.78583541
42EEF2K0.75783430
43WNK10.75705689
44IRAK10.73935871
45RIPK40.72366373
46TESK20.69823193
47MAP2K20.69816659
48RPS6KC10.67096692
49RPS6KL10.67096692
50CHEK20.66470275
51TTK0.66291729
52CCNB10.65620773
53PASK0.65358393
54PRKAA20.63271208
55STK30.63142860
56ARAF0.58762766
57PINK10.57338419
58MAPK110.57004142
59UHMK10.55517341
60RPS6KA60.54626285
61LMTK20.53383689
62CAMK1G0.52358528
63MAP2K60.51758771
64STK38L0.50537321
65FES0.48267872
66MAPK10.47840279
67MAP2K30.47685275
68ROCK10.47643176
69AKT30.46394410
70JAK20.45878133
71CDC42BPA0.45537825
72IRAK20.45174165
73PAK10.43680941
74MUSK0.42609455
75CSK0.42533442
76MAP3K70.40460126
77NTRK20.40178213
78ERN10.39776289
79SYK0.39471468
80CHEK10.39364260
81BTK0.38599919
82CAMK40.38234349
83KIT0.37612336
84PRKCG0.37559718
85IKBKB0.37041179
86CDK30.36693195
87GRK60.35520910
88TNK20.34740214
89TRIB30.34279427
90CAMK10.34272363
91WEE10.34056366
92PAK20.32019746
93BRSK20.31258017
94HCK0.30351223
95PLK40.29312822
96MTOR0.29064926
97MAP3K100.29029051
98SMG10.28651048
99PAK40.28208648
100ATM0.27988680
101MARK20.26182282
102MAPK100.26084458
103LYN0.24720783
104TYK20.24433193
105ATR0.24030223
106SGK10.22973031
107PRKAA10.22797188
108CDK190.22385511
109NEK60.22285191
110RAF10.22066873
111AKT10.21700894
112ITK0.21432022
113CAMKK10.21338420
114MAPK140.20906514
115MAPKAPK50.20317430
116BRSK10.18759525
117PRKCZ0.18461523
118CDK120.17903506
119PLK10.16243480
120RPS6KB10.15252811
121CDK150.13659949
122CDC70.12592061
123PRKCQ0.12536202
124CDK180.10875929
125RPS6KA10.10458822
126PRKG20.10447483
127CDK11A0.10096336
128MARK30.09166714
129CSF1R0.08926550
130STK100.08271366
131CSNK2A10.07825818
132GSK3B0.07608981
133BRAF0.07038945
134CDK60.06139703
135CDK140.05816836
136CDK20.04934928
137PIM10.04508523
138STK110.04211022
139ZAP700.03796104
140PKN10.03661290
141CDK10.03536624
142PRKCD0.03498708
143CAMK2A0.02895722
144CSNK2A20.02683622
145MAPK80.02661446
146CSNK1D0.02591687
147PRKACG0.02254193
148AURKA0.02018208
149PRKG10.01513594
150CDK40.01298143
151PRKCB0.01199020
152CLK10.01002909
153PRKCA0.00171616
154PRKDC-0.0355859
155MAP3K4-0.0310110
156RPS6KA3-0.0283146
157YES1-0.0254194
158RIPK1-0.0195942
159MAP3K5-0.0108716
160EGFR-0.0098394
161PDGFRB-0.0045020
162PAK6-0.0017587

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.18454432
2Fatty acid biosynthesis_Homo sapiens_hsa000614.80752937
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.29897438
4Vitamin B6 metabolism_Homo sapiens_hsa007503.38341226
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.21922320
6Pyruvate metabolism_Homo sapiens_hsa006203.20504736
7Linoleic acid metabolism_Homo sapiens_hsa005913.12621306
8Olfactory transduction_Homo sapiens_hsa047403.07547838
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74897105
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.50200760
11Glucagon signaling pathway_Homo sapiens_hsa049222.48758045
12Propanoate metabolism_Homo sapiens_hsa006402.44995707
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.39608735
14Basal transcription factors_Homo sapiens_hsa030222.32768363
15Allograft rejection_Homo sapiens_hsa053302.29488010
16Autoimmune thyroid disease_Homo sapiens_hsa053202.18752465
17Acute myeloid leukemia_Homo sapiens_hsa052212.12840403
18Graft-versus-host disease_Homo sapiens_hsa053322.12814237
19Glycerolipid metabolism_Homo sapiens_hsa005612.00967933
20Selenocompound metabolism_Homo sapiens_hsa004502.00392273
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97346514
22PPAR signaling pathway_Homo sapiens_hsa033201.88989331
23Type I diabetes mellitus_Homo sapiens_hsa049401.87865706
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.85538790
25Type II diabetes mellitus_Homo sapiens_hsa049301.77535870
26B cell receptor signaling pathway_Homo sapiens_hsa046621.75802456
27Pentose phosphate pathway_Homo sapiens_hsa000301.74212277
28Viral myocarditis_Homo sapiens_hsa054161.71765456
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68122516
30Fructose and mannose metabolism_Homo sapiens_hsa000511.67779534
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.66100003
32Oocyte meiosis_Homo sapiens_hsa041141.62777767
33Fat digestion and absorption_Homo sapiens_hsa049751.56371190
34Influenza A_Homo sapiens_hsa051641.54520086
35Mineral absorption_Homo sapiens_hsa049781.54423603
36Amphetamine addiction_Homo sapiens_hsa050311.51312726
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51035095
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.45219399
39Ether lipid metabolism_Homo sapiens_hsa005651.43882261
40Fatty acid metabolism_Homo sapiens_hsa012121.40019500
41Fatty acid degradation_Homo sapiens_hsa000711.38698281
42Carbon metabolism_Homo sapiens_hsa012001.35965636
43Dorso-ventral axis formation_Homo sapiens_hsa043201.34501474
44Cardiac muscle contraction_Homo sapiens_hsa042601.32438467
45Fanconi anemia pathway_Homo sapiens_hsa034601.29382934
46Osteoclast differentiation_Homo sapiens_hsa043801.27880364
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26187005
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17729539
49Leishmaniasis_Homo sapiens_hsa051401.14242818
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13442370
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.08658000
52Herpes simplex infection_Homo sapiens_hsa051681.08558822
53Antigen processing and presentation_Homo sapiens_hsa046121.07822018
54Glutathione metabolism_Homo sapiens_hsa004801.06432850
55mRNA surveillance pathway_Homo sapiens_hsa030151.03378003
56Butanoate metabolism_Homo sapiens_hsa006501.00601433
57Renin secretion_Homo sapiens_hsa049241.00220304
58Purine metabolism_Homo sapiens_hsa002300.99579579
59Huntingtons disease_Homo sapiens_hsa050160.98037782
60Hedgehog signaling pathway_Homo sapiens_hsa043400.97483156
61Collecting duct acid secretion_Homo sapiens_hsa049660.93559896
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.91375780
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90752725
64RNA transport_Homo sapiens_hsa030130.90229590
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88259694
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.87466228
67T cell receptor signaling pathway_Homo sapiens_hsa046600.86304446
68Biosynthesis of amino acids_Homo sapiens_hsa012300.85941003
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85934264
70Arachidonic acid metabolism_Homo sapiens_hsa005900.84540969
71Toxoplasmosis_Homo sapiens_hsa051450.83952859
72Other glycan degradation_Homo sapiens_hsa005110.83013729
73Renin-angiotensin system_Homo sapiens_hsa046140.81475451
74Insulin secretion_Homo sapiens_hsa049110.80379762
75Systemic lupus erythematosus_Homo sapiens_hsa053220.79985195
76MAPK signaling pathway_Homo sapiens_hsa040100.73968358
77Non-small cell lung cancer_Homo sapiens_hsa052230.73643272
78Thyroid hormone synthesis_Homo sapiens_hsa049180.73634357
79Measles_Homo sapiens_hsa051620.73585582
80Estrogen signaling pathway_Homo sapiens_hsa049150.73528692
81Chemical carcinogenesis_Homo sapiens_hsa052040.72659200
82Bile secretion_Homo sapiens_hsa049760.71672910
83Long-term potentiation_Homo sapiens_hsa047200.69998004
84Chemokine signaling pathway_Homo sapiens_hsa040620.66798813
85Prolactin signaling pathway_Homo sapiens_hsa049170.65959967
86Epstein-Barr virus infection_Homo sapiens_hsa051690.65472753
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65279679
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64785403
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63096122
90mTOR signaling pathway_Homo sapiens_hsa041500.60812427
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60371825
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.60135606
93Phenylalanine metabolism_Homo sapiens_hsa003600.59896928
94Legionellosis_Homo sapiens_hsa051340.59164862
95Tuberculosis_Homo sapiens_hsa051520.58823137
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57434719
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54111759
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54092858
99Pancreatic secretion_Homo sapiens_hsa049720.52966264
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51087171
101Synaptic vesicle cycle_Homo sapiens_hsa047210.50528254
102Protein digestion and absorption_Homo sapiens_hsa049740.50087572
103Staphylococcus aureus infection_Homo sapiens_hsa051500.49611545
104ABC transporters_Homo sapiens_hsa020100.49487404
105Salivary secretion_Homo sapiens_hsa049700.48808125
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47912379
107AMPK signaling pathway_Homo sapiens_hsa041520.47844294
108Calcium signaling pathway_Homo sapiens_hsa040200.47828656
109Endocytosis_Homo sapiens_hsa041440.47628913
110Arginine and proline metabolism_Homo sapiens_hsa003300.47029805
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47018223
112Phagosome_Homo sapiens_hsa041450.46667326
113Hepatitis B_Homo sapiens_hsa051610.44908688
114Choline metabolism in cancer_Homo sapiens_hsa052310.44003292
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.43980456
116Chronic myeloid leukemia_Homo sapiens_hsa052200.43732350
117Malaria_Homo sapiens_hsa051440.42519992
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.42184349
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41956547
120Inositol phosphate metabolism_Homo sapiens_hsa005620.41803491
121Alcoholism_Homo sapiens_hsa050340.41328095
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41221057
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38678923
124Gastric acid secretion_Homo sapiens_hsa049710.38431871
125Hematopoietic cell lineage_Homo sapiens_hsa046400.38357554
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.38168882
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.37933689
128Morphine addiction_Homo sapiens_hsa050320.37256196
129Insulin signaling pathway_Homo sapiens_hsa049100.36787993
130Metabolic pathways_Homo sapiens_hsa011000.36118468
131Primary immunodeficiency_Homo sapiens_hsa053400.35125175
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34945160
133Arginine biosynthesis_Homo sapiens_hsa002200.34546180
134Taste transduction_Homo sapiens_hsa047420.33600924
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32706235
136Prostate cancer_Homo sapiens_hsa052150.32101053
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.32066287
138cAMP signaling pathway_Homo sapiens_hsa040240.30766931
139VEGF signaling pathway_Homo sapiens_hsa043700.30005866
140Platelet activation_Homo sapiens_hsa046110.29929778
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28848445
142Pyrimidine metabolism_Homo sapiens_hsa002400.28641812
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26283928
144Circadian entrainment_Homo sapiens_hsa047130.23540849
145Cocaine addiction_Homo sapiens_hsa050300.23340698
146Sulfur metabolism_Homo sapiens_hsa009200.18321579
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17387348
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16822899
149Basal cell carcinoma_Homo sapiens_hsa052170.13330233
150Viral carcinogenesis_Homo sapiens_hsa052030.12582003
151HIF-1 signaling pathway_Homo sapiens_hsa040660.12407768
152Salmonella infection_Homo sapiens_hsa051320.12390898
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10345217
154N-Glycan biosynthesis_Homo sapiens_hsa005100.10189720
155Wnt signaling pathway_Homo sapiens_hsa043100.08068080
156Insulin resistance_Homo sapiens_hsa049310.07073581

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