TSHZ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.20681240
2postsynaptic membrane organization (GO:0001941)4.79160362
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.67272744
4presynaptic membrane organization (GO:0097090)4.60667870
5neuron cell-cell adhesion (GO:0007158)4.50066377
6synaptic vesicle exocytosis (GO:0016079)4.44156494
7protein heterotrimerization (GO:0070208)4.37513726
8glutamate secretion (GO:0014047)4.30163728
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29956251
10regulation of synaptic vesicle exocytosis (GO:2000300)4.11858998
11vocalization behavior (GO:0071625)4.08883995
12cell migration involved in heart development (GO:0060973)4.02369822
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99927789
14protein localization to synapse (GO:0035418)3.92054801
15neuronal action potential propagation (GO:0019227)3.88937608
16kidney mesenchyme development (GO:0072074)3.72305068
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68814433
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.67952722
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65529430
20regulation of glutamate receptor signaling pathway (GO:1900449)3.64788946
21collagen fibril organization (GO:0030199)3.61256339
22cell migration in hindbrain (GO:0021535)3.61095911
23dermatan sulfate biosynthetic process (GO:0030208)3.58772772
24metanephric mesenchyme development (GO:0072075)3.56793446
25extracellular matrix assembly (GO:0085029)3.53666886
26synaptic vesicle maturation (GO:0016188)3.52423893
27neuron recognition (GO:0008038)3.48232157
28dermatan sulfate metabolic process (GO:0030205)3.41911289
29axon extension involved in axon guidance (GO:0048846)3.40166635
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.40166635
31regulation of synaptic vesicle transport (GO:1902803)3.38506880
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38406302
33axonal fasciculation (GO:0007413)3.36652569
34detection of molecule of bacterial origin (GO:0032490)3.34130685
35neurotransmitter-gated ion channel clustering (GO:0072578)3.24597281
36dendrite morphogenesis (GO:0048813)3.24196375
37substrate-dependent cell migration (GO:0006929)3.17415455
38chondrocyte proliferation (GO:0035988)3.11389890
39endodermal cell differentiation (GO:0035987)3.08637156
40synaptic transmission, glutamatergic (GO:0035249)3.08195207
41detection of calcium ion (GO:0005513)3.06602494
42layer formation in cerebral cortex (GO:0021819)3.04189024
43skin morphogenesis (GO:0043589)3.02478426
44locomotory exploration behavior (GO:0035641)3.01552860
45bone trabecula formation (GO:0060346)2.97651620
46neuron-neuron synaptic transmission (GO:0007270)2.96157471
47negative regulation of dendrite morphogenesis (GO:0050774)2.95686145
48cerebellar Purkinje cell differentiation (GO:0021702)2.95082770
49pericardium development (GO:0060039)2.95017674
50positive regulation of synapse assembly (GO:0051965)2.94597718
51heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.94531229
52chondroitin sulfate biosynthetic process (GO:0030206)2.94140158
53mesenchymal-epithelial cell signaling (GO:0060638)2.93774497
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91506914
55neurotransmitter secretion (GO:0007269)2.91183352
56innervation (GO:0060384)2.90913752
57central nervous system projection neuron axonogenesis (GO:0021952)2.90682633
58cerebellar granule cell differentiation (GO:0021707)2.89330175
59regulation of synapse assembly (GO:0051963)2.88390099
60glutamate receptor signaling pathway (GO:0007215)2.88177137
61extracellular fibril organization (GO:0043206)2.86832561
62protein localization to endosome (GO:0036010)2.85351791
63proline transport (GO:0015824)2.84984131
64ionotropic glutamate receptor signaling pathway (GO:0035235)2.84814889
65regulation of neurotransmitter secretion (GO:0046928)2.83432561
66mechanosensory behavior (GO:0007638)2.83198553
67gamma-aminobutyric acid signaling pathway (GO:0007214)2.82898260
68* regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80858187
69negative regulation of smooth muscle cell migration (GO:0014912)2.80479523
70positive regulation of fibroblast migration (GO:0010763)2.78370015
71startle response (GO:0001964)2.77420405
72long-term synaptic potentiation (GO:0060291)2.76804554
73positive regulation of synapse maturation (GO:0090129)2.75915408
74regulation of vesicle fusion (GO:0031338)2.75027612
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72686629
76synapse assembly (GO:0007416)2.72644970
77fibril organization (GO:0097435)2.70184912
78dendritic spine morphogenesis (GO:0060997)2.70122516
79regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67872015
80membrane assembly (GO:0071709)2.67785518
81regulation of postsynaptic membrane potential (GO:0060078)2.67088776
82barbed-end actin filament capping (GO:0051016)2.66397529
83exploration behavior (GO:0035640)2.65293468
84central nervous system neuron axonogenesis (GO:0021955)2.64963274
85negative regulation of axon extension involved in axon guidance (GO:0048843)2.64786844
86heparan sulfate proteoglycan metabolic process (GO:0030201)2.64395202
87sequestering of extracellular ligand from receptor (GO:0035581)2.63963663
88regulation of neuronal synaptic plasticity (GO:0048168)2.63885007
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.62138844
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61849436
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61849436
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.61849436
93modulation by symbiont of host immune response (GO:0052553)2.61849436
94positive regulation by symbiont of host defense response (GO:0052509)2.61849436
95modulation by symbiont of host defense response (GO:0052031)2.61849436
96regulation of axon extension involved in axon guidance (GO:0048841)2.61688794
97negative regulation of axon guidance (GO:1902668)2.59015722
98regulation of axon guidance (GO:1902667)2.58319015
99* regulation of respiratory system process (GO:0044065)2.57646226
100stress fiber assembly (GO:0043149)2.57438790
101lymphangiogenesis (GO:0001946)2.57305484
102positive regulation of membrane potential (GO:0045838)2.56247431
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.55725380
104membrane depolarization during action potential (GO:0086010)2.54542858
105negative regulation of dendrite development (GO:2000171)2.54435376
106positive regulation of axon extension (GO:0045773)2.54343999
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53298384
108regulation of synaptic transmission, GABAergic (GO:0032228)2.53011524
109activation of protein kinase A activity (GO:0034199)2.52355967
110gamma-aminobutyric acid transport (GO:0015812)2.52259883
111adhesion of symbiont to host cell (GO:0044650)2.51595826
112virion attachment to host cell (GO:0019062)2.51595826
113neuron projection extension (GO:1990138)2.51016503
114tooth mineralization (GO:0034505)2.50149971
115transmission of nerve impulse (GO:0019226)2.50036415
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.49337818
117planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48726857
118collagen metabolic process (GO:0032963)2.48565662
119collagen catabolic process (GO:0030574)2.48157236
120regulation of neuron migration (GO:2001222)2.46823589
121positive regulation of neurotransmitter secretion (GO:0001956)2.46693068
122synapse organization (GO:0050808)2.46675107
123regulation of synapse organization (GO:0050807)2.46288911
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.46182768
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.44970686
126regulation of neurotransmitter transport (GO:0051588)2.44658815
127regulation of synaptic plasticity (GO:0048167)2.44515640
128synaptic vesicle endocytosis (GO:0048488)2.44162302
129cell migration involved in sprouting angiogenesis (GO:0002042)2.44122615
130regulation of macrophage cytokine production (GO:0010935)2.43922900
131cerebral cortex radially oriented cell migration (GO:0021799)2.42253457
132membrane depolarization (GO:0051899)2.41125265
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40800546
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.39984837
135axon extension (GO:0048675)2.39335923
136regulation of synapse structural plasticity (GO:0051823)2.39332427
137regulation of dendritic spine development (GO:0060998)2.38724520
138cell differentiation in hindbrain (GO:0021533)2.38111728
139regulation of synapse maturation (GO:0090128)2.37925664
140regulation of voltage-gated calcium channel activity (GO:1901385)2.37242663
141antigen processing and presentation via MHC class Ib (GO:0002475)2.36607389
142calcium ion-dependent exocytosis (GO:0017156)2.36555834
143vascular endothelial growth factor signaling pathway (GO:0038084)2.35829674
144neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.35215086
145regulation of cell communication by electrical coupling (GO:0010649)2.35197456
146venous blood vessel morphogenesis (GO:0048845)2.34907860
147long-term memory (GO:0007616)2.33848731
148* regulation of respiratory gaseous exchange (GO:0043576)2.33788582
149neuromuscular synaptic transmission (GO:0007274)2.33524778
150regulation of dendritic spine morphogenesis (GO:0061001)2.33389849
151pyrimidine nucleobase catabolic process (GO:0006208)2.32928875
152neurotransmitter transport (GO:0006836)2.31794094
153phosphorelay signal transduction system (GO:0000160)2.31474422
154import into cell (GO:0098657)2.29265211
155smooth muscle tissue development (GO:0048745)2.26911074
156multicellular organismal macromolecule metabolic process (GO:0044259)2.26250296
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24815461
158negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24349021
159SMAD protein complex assembly (GO:0007183)2.23563152
160chondrocyte development (GO:0002063)2.23297665
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.21738732
162positive regulation of epithelial to mesenchymal transition (GO:0010718)2.21552609
163negative regulation of interleukin-12 production (GO:0032695)2.20402938
164proteoglycan biosynthetic process (GO:0030166)2.20373038
165negative chemotaxis (GO:0050919)2.20147109
166multicellular organismal catabolic process (GO:0044243)2.18836495
167artery development (GO:0060840)2.17845346
168positive regulation of macrophage cytokine production (GO:0060907)2.17777865
169macrophage activation involved in immune response (GO:0002281)2.17156490
170regulation of T-helper 2 cell differentiation (GO:0045628)2.16073370
171growth hormone secretion (GO:0030252)2.16022145
172response to peptidoglycan (GO:0032494)2.15176413
173regulation of NFAT protein import into nucleus (GO:0051532)2.14252271
174extracellular matrix disassembly (GO:0022617)2.10921186
175response to fluid shear stress (GO:0034405)2.10814798
176cortical actin cytoskeleton organization (GO:0030866)2.10558095
177outer ear morphogenesis (GO:0042473)2.10237054
178negative regulation of glial cell proliferation (GO:0060253)2.09818739
179facial nerve structural organization (GO:0021612)2.09644943
180positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.08931716
181positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.08688036
182multicellular organismal metabolic process (GO:0044236)2.08339102
183regulation of fibroblast migration (GO:0010762)2.05909860
184negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.05773965
185regulation of axon extension (GO:0030516)2.05046393
186positive regulation of receptor recycling (GO:0001921)2.04931921
187positive regulation of gastrulation (GO:2000543)2.04729989
188vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.03537996
189positive regulation of BMP signaling pathway (GO:0030513)2.03136901
190keratan sulfate catabolic process (GO:0042340)2.02662784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82275381
2GBX2_23144817_ChIP-Seq_PC3_Human4.13430626
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85380423
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78282416
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77342091
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71709974
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.56918966
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51563434
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51563434
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.45842309
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45354429
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42746207
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35290345
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33518011
15TAF15_26573619_Chip-Seq_HEK293_Human2.29226242
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22892986
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16792308
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09631622
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03662791
20* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02947777
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01370797
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01125680
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95281688
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.93181838
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.89797159
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89174467
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88569432
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85156483
29AR_21572438_ChIP-Seq_LNCaP_Human1.84813333
30P300_19829295_ChIP-Seq_ESCs_Human1.83318471
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80681805
32REST_21632747_ChIP-Seq_MESCs_Mouse1.80534657
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79527053
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76935501
35* PIAS1_25552417_ChIP-Seq_VCAP_Human1.76926178
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76563311
37SMAD4_21799915_ChIP-Seq_A2780_Human1.74246387
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73326759
39* CBX2_27304074_Chip-Seq_ESCs_Mouse1.73274914
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70304917
41* DROSHA_22980978_ChIP-Seq_HELA_Human1.66711703
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63969808
43FUS_26573619_Chip-Seq_HEK293_Human1.63889380
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63002244
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62337532
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60391235
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59611536
48BRD4_25478319_ChIP-Seq_HGPS_Human1.58599556
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57987567
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56616008
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55076129
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54806034
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.53971520
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53611968
55* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53213149
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52978941
57RNF2_27304074_Chip-Seq_NSC_Mouse1.52247956
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.50179262
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49679213
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48713230
61TP53_16413492_ChIP-PET_HCT116_Human1.48299298
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46099870
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45058626
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42527317
65VDR_22108803_ChIP-Seq_LS180_Human1.42480242
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41020571
67CJUN_26792858_Chip-Seq_BT549_Human1.40993924
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40163301
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.39838601
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38427760
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.36566779
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36280359
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.34458009
74ZNF274_21170338_ChIP-Seq_K562_Hela1.32628742
75TP53_18474530_ChIP-ChIP_U2OS_Human1.32277063
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.32004546
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31981597
78AHR_22903824_ChIP-Seq_MCF-7_Human1.31840456
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31444562
80VDR_24787735_ChIP-Seq_THP-1_Human1.29600758
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29493448
82* STAT3_23295773_ChIP-Seq_U87_Human1.29036232
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27378852
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26921461
85AR_25329375_ChIP-Seq_VCAP_Human1.26824935
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22233195
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22027717
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21958200
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.21452500
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.21240246
91ER_23166858_ChIP-Seq_MCF-7_Human1.21186718
92* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20588494
93* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20271127
94* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19991272
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19420535
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18818782
97* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17753813
98RUNX2_22187159_ChIP-Seq_PCA_Human1.17317776
99TCF4_23295773_ChIP-Seq_U87_Human1.16517697
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.16240168
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16153347
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15782759
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15490427
104* KDM2B_26808549_Chip-Seq_K562_Human1.14037870
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12246701
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12246701
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.11866171
108* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11706883
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11513362
110AR_19668381_ChIP-Seq_PC3_Human1.11065071
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09820414
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09820414
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09820414
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09742380
115SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09183584
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09014630
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07982103
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06760858
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05668334
120* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05525905
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05297592
122JUN_21703547_ChIP-Seq_K562_Human1.04943670
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03875654
124* KDM2B_26808549_Chip-Seq_REH_Human1.03008653
125BCAT_22108803_ChIP-Seq_LS180_Human1.02565032
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02211293
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00427333
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00427333
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00193037
130SMAD3_21741376_ChIP-Seq_ESCs_Human1.00127892
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98573751
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98125693
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.96842322
134IGF1R_20145208_ChIP-Seq_DFB_Human0.96688930
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.95915482
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95218708
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94237874
138EWS_26573619_Chip-Seq_HEK293_Human0.94128284
139* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94117062
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90822702
141* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90680585
142* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86663749
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84596451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.94613295
2MP0003705_abnormal_hypodermis_morpholog3.91773591
3MP0003279_aneurysm3.77138782
4MP0004270_analgesia3.62689635
5MP0001958_emphysema3.50681974
6MP0004859_abnormal_synaptic_plasticity3.26785311
7MP0003635_abnormal_synaptic_transmissio2.76099444
8MP0003787_abnormal_imprinting2.64229452
9MP0003122_maternal_imprinting2.56879812
10MP0009780_abnormal_chondrocyte_physiolo2.46978706
11MP0005257_abnormal_intraocular_pressure2.45981374
12MP0001968_abnormal_touch/_nociception2.45756129
13* MP0002734_abnormal_mechanical_nocicepti2.37224723
14MP0010386_abnormal_urinary_bladder2.37199746
15MP0006054_spinal_hemorrhage2.32746086
16MP0001542_abnormal_bone_strength2.32160499
17MP0009745_abnormal_behavioral_response2.27903622
18MP0002063_abnormal_learning/memory/cond2.26598322
19MP0001188_hyperpigmentation2.10511313
20MP0002064_seizures2.05867216
21MP0001984_abnormal_olfaction2.05616218
22MP0002735_abnormal_chemical_nociception2.04908988
23MP0003091_abnormal_cell_migration2.03741384
24MP0000778_abnormal_nervous_system2.03527150
25MP0002572_abnormal_emotion/affect_behav2.02729313
26MP0009046_muscle_twitch2.01408071
27MP0002837_dystrophic_cardiac_calcinosis1.97944093
28MP0001486_abnormal_startle_reflex1.96350965
29* MP0000767_abnormal_smooth_muscle1.96040774
30MP0002272_abnormal_nervous_system1.95098254
31MP0005508_abnormal_skeleton_morphology1.88535715
32MP0002736_abnormal_nociception_after1.88386199
33MP0002184_abnormal_innervation1.83557884
34MP0004510_myositis1.76430770
35MP0006276_abnormal_autonomic_nervous1.75112950
36MP0003566_abnormal_cell_adhesion1.70502908
37MP0010368_abnormal_lymphatic_system1.70179816
38MP0002067_abnormal_sensory_capabilities1.70041170
39MP0002295_abnormal_pulmonary_circulatio1.63037228
40MP0005503_abnormal_tendon_morphology1.60020830
41MP0002733_abnormal_thermal_nociception1.58555062
42MP0003123_paternal_imprinting1.57284841
43MP0001440_abnormal_grooming_behavior1.55104223
44* MP0001970_abnormal_pain_threshold1.54320238
45MP0003121_genomic_imprinting1.53058849
46MP0005390_skeleton_phenotype1.52788877
47MP0002557_abnormal_social/conspecific_i1.50777441
48MP0000569_abnormal_digit_pigmentation1.48151572
49MP0009384_cardiac_valve_regurgitation1.48144622
50MP0005171_absent_coat_pigmentation1.46963894
51MP0005646_abnormal_pituitary_gland1.46954212
52MP0005423_abnormal_somatic_nervous1.46698052
53MP0008438_abnormal_cutaneous_collagen1.45146497
54MP0004145_abnormal_muscle_electrophysio1.44677672
55MP0005499_abnormal_olfactory_system1.43459012
56MP0005394_taste/olfaction_phenotype1.43459012
57MP0003879_abnormal_hair_cell1.38980457
58MP0003385_abnormal_body_wall1.37859474
59MP0000013_abnormal_adipose_tissue1.37577707
60MP0005595_abnormal_vascular_smooth1.36999473
61MP0001533_abnormal_skeleton_physiology1.36298737
62MP0001849_ear_inflammation1.36078134
63MP0000955_abnormal_spinal_cord1.32415297
64MP0003724_increased_susceptibility_to1.30459231
65MP0001501_abnormal_sleep_pattern1.28539889
66MP0000751_myopathy1.25866477
67MP0000428_abnormal_craniofacial_morphol1.25720313
68MP0004811_abnormal_neuron_physiology1.25646774
69MP0002882_abnormal_neuron_morphology1.23863686
70MP0002163_abnormal_gland_morphology1.23711568
71MP0008789_abnormal_olfactory_epithelium1.22569165
72MP0005623_abnormal_meninges_morphology1.22401640
73MP0003303_peritoneal_inflammation1.22138488
74MP0005023_abnormal_wound_healing1.21097182
75MP0003828_pulmonary_edema1.19961515
76MP0000631_abnormal_neuroendocrine_gland1.19880367
77MP0009053_abnormal_anal_canal1.18259420
78MP0008569_lethality_at_weaning1.17814101
79MP0009250_abnormal_appendicular_skeleto1.17625317
80MP0001348_abnormal_lacrimal_gland1.15929979
81MP0004924_abnormal_behavior1.14449066
82MP0005386_behavior/neurological_phenoty1.14449066
83MP0003436_decreased_susceptibility_to1.13723199
84MP0003950_abnormal_plasma_membrane1.12547107
85MP0002060_abnormal_skin_morphology1.11954323
86MP0000733_abnormal_muscle_development1.10954680
87MP0001299_abnormal_eye_distance/1.10466925
88MP0005379_endocrine/exocrine_gland_phen1.09685316
89MP0002751_abnormal_autonomic_nervous1.07839420
90MP0005164_abnormal_response_to1.07492941
91MP0002998_abnormal_bone_remodeling1.07071224
92MP0003448_altered_tumor_morphology1.06530298
93MP0004883_abnormal_blood_vessel1.04158124
94MP0004233_abnormal_muscle_weight1.00866119
95* MP0005388_respiratory_system_phenotype0.98597840
96* MP0002133_abnormal_respiratory_system0.98597840
97MP0004885_abnormal_endolymph0.98544528
98MP0000537_abnormal_urethra_morphology0.98508287
99MP0005645_abnormal_hypothalamus_physiol0.98321696
100* MP0002066_abnormal_motor_capabilities/c0.97924238
101MP0006082_CNS_inflammation0.97570414
102MP0000516_abnormal_urinary_system0.95423946
103MP0005367_renal/urinary_system_phenotyp0.95423946
104MP0003755_abnormal_palate_morphology0.94449268
105MP0002115_abnormal_skeleton_extremities0.94381910
106MP0000750_abnormal_muscle_regeneration0.93814296
107MP0003300_gastrointestinal_ulcer0.93690667
108MP0010030_abnormal_orbit_morphology0.93675590
109MP0003075_altered_response_to0.93513416
110MP0002876_abnormal_thyroid_physiology0.92582634
111MP0003115_abnormal_respiratory_system0.92525969
112MP0003172_abnormal_lysosome_physiology0.91867951
113MP0002152_abnormal_brain_morphology0.91769190
114MP0000163_abnormal_cartilage_morphology0.91658947
115MP0002108_abnormal_muscle_morphology0.91216213
116MP0002254_reproductive_system_inflammat0.90715275
117MP0004858_abnormal_nervous_system0.89550952
118MP0004742_abnormal_vestibular_system0.89373836
119MP0004085_abnormal_heartbeat0.87777376
120MP0002932_abnormal_joint_morphology0.87696379
121MP0009278_abnormal_bone_marrow0.86207189
122MP0001963_abnormal_hearing_physiology0.86195292
123MP0008004_abnormal_stomach_pH0.86173053
124* MP0003942_abnormal_urinary_system0.85861659
125MP0010352_gastrointestinal_tract_polyps0.85029943
126MP0002113_abnormal_skeleton_development0.84661024
127MP0002909_abnormal_adrenal_gland0.84263261
128MP0001502_abnormal_circadian_rhythm0.83621586
129* MP0001177_atelectasis0.83368619
130MP0005076_abnormal_cell_differentiation0.82866394
131MP0003329_amyloid_beta_deposits0.82484221
132MP0001986_abnormal_taste_sensitivity0.80802545
133MP0000372_irregular_coat_pigmentation0.80371065
134MP0002752_abnormal_somatic_nervous0.80036547
135MP0000759_abnormal_skeletal_muscle0.80030978
136MP0000432_abnormal_head_morphology0.79716309
137MP0001905_abnormal_dopamine_level0.79392020
138MP0005275_abnormal_skin_tensile0.78402801
139MP0002102_abnormal_ear_morphology0.77193441
140MP0000049_abnormal_middle_ear0.76644367
141MP0002249_abnormal_larynx_morphology0.76575053
142MP0002116_abnormal_craniofacial_bone0.75760218
143* MP0000534_abnormal_ureter_morphology0.75415081
144MP0004142_abnormal_muscle_tone0.74676289
145MP0001485_abnormal_pinna_reflex0.74640343
146MP0001175_abnormal_lung_morphology0.74166624
147MP0002877_abnormal_melanocyte_morpholog0.74051677
148MP0003634_abnormal_glial_cell0.73206564
149MP0006072_abnormal_retinal_apoptosis0.73192451
150MP0003935_abnormal_craniofacial_develop0.72494415
151MP0002160_abnormal_reproductive_system0.72248839
152MP0000604_amyloidosis0.72190981
153MP0000026_abnormal_inner_ear0.71905386
154MP0002177_abnormal_outer_ear0.71701263
155MP0003283_abnormal_digestive_organ0.71244016
156MP0002234_abnormal_pharynx_morphology0.71181302
157MP0002896_abnormal_bone_mineralization0.70372831
158MP0002282_abnormal_trachea_morphology0.69265376
159MP0002114_abnormal_axial_skeleton0.68214083
160MP0004272_abnormal_basement_membrane0.68037421
161MP0001879_abnormal_lymphatic_vessel0.68006467
162MP0001270_distended_abdomen0.67958588
163MP0000538_abnormal_urinary_bladder0.66873026
164MP0003045_fibrosis0.66767078
165MP0002925_abnormal_cardiovascular_devel0.66576253
166MP0005551_abnormal_eye_electrophysiolog0.65607162
167MP0001243_abnormal_dermal_layer0.65014380
168MP0003795_abnormal_bone_structure0.64572691
169MP0001614_abnormal_blood_vessel0.64570461
170MP0002168_other_aberrant_phenotype0.64125600
171MP0005409_darkened_coat_color0.63285299
172MP0005197_abnormal_uvea_morphology0.62685265

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.73673641
2Protrusio acetabuli (HP:0003179)5.19639546
3Atonic seizures (HP:0010819)4.87521707
4Aortic aneurysm (HP:0004942)4.50960588
5Epileptic encephalopathy (HP:0200134)4.19939911
6Aortic dissection (HP:0002647)4.12764862
7Focal seizures (HP:0007359)4.05799140
8Genu recurvatum (HP:0002816)3.97484446
9Febrile seizures (HP:0002373)3.86804978
10Ankle contracture (HP:0006466)3.82928843
11Soft skin (HP:0000977)3.82837082
12Follicular hyperkeratosis (HP:0007502)3.79755305
13Peritonitis (HP:0002586)3.76647349
14Broad metatarsal (HP:0001783)3.73870486
15Vascular tortuosity (HP:0004948)3.71688429
16Bladder diverticulum (HP:0000015)3.49713036
17Slender build (HP:0001533)3.46754751
18Type 1 muscle fiber predominance (HP:0003803)3.38192941
19Hyperventilation (HP:0002883)3.35347835
20Spondylolisthesis (HP:0003302)3.34719959
21Hepatoblastoma (HP:0002884)3.28927614
22Arterial tortuosity (HP:0005116)3.25680884
23Atrophic scars (HP:0001075)3.24809416
24Absence seizures (HP:0002121)3.15857927
25Broad-based gait (HP:0002136)3.04519042
26Shallow orbits (HP:0000586)3.01535176
27Hypothermia (HP:0002045)2.92664186
28Dialeptic seizures (HP:0011146)2.92368330
29Progressive cerebellar ataxia (HP:0002073)2.92292655
30Dilatation of the ascending aorta (HP:0005111)2.85739875
31Cervical subluxation (HP:0003308)2.85577321
32Visual hallucinations (HP:0002367)2.85547801
33Abnormality of dentin (HP:0010299)2.84535565
34Myokymia (HP:0002411)2.83419100
35Protruding tongue (HP:0010808)2.78974419
36Bowel diverticulosis (HP:0005222)2.78117323
37Spinal rigidity (HP:0003306)2.77923880
38Fragile skin (HP:0001030)2.73051944
39Amblyopia (HP:0000646)2.70849511
40Neonatal short-limb short stature (HP:0008921)2.68413603
41Mitral valve prolapse (HP:0001634)2.64932855
42Wormian bones (HP:0002645)2.64258196
43Joint laxity (HP:0001388)2.61577292
44Breast hypoplasia (HP:0003187)2.58847558
45Overgrowth (HP:0001548)2.58796215
46Hyperextensible skin (HP:0000974)2.57178457
47Generalized tonic-clonic seizures (HP:0002069)2.57156478
48Abnormal hair whorl (HP:0010721)2.52522417
49Exotropia (HP:0000577)2.50890554
50Blue sclerae (HP:0000592)2.49539927
51Increased variability in muscle fiber diameter (HP:0003557)2.46884149
52Epileptiform EEG discharges (HP:0011182)2.43302746
53Agitation (HP:0000713)2.41337133
54Hypoventilation (HP:0002791)2.35967324
55Wide anterior fontanel (HP:0000260)2.34994490
56Cerebral aneurysm (HP:0004944)2.34566073
57Absent speech (HP:0001344)2.31414367
58Drooling (HP:0002307)2.31374369
59Excessive salivation (HP:0003781)2.31374369
60Blue irides (HP:0000635)2.31005766
61Gaze-evoked nystagmus (HP:0000640)2.30103862
62EEG with generalized epileptiform discharges (HP:0011198)2.28063889
63Hypoplasia of the maxilla (HP:0000327)2.26655899
64Disproportionate tall stature (HP:0001519)2.23699732
65Hyperthyroidism (HP:0000836)2.22238096
66Gait imbalance (HP:0002141)2.20932280
67Aneurysm (HP:0002617)2.20429701
68Fetal akinesia sequence (HP:0001989)2.19770279
69Mild short stature (HP:0003502)2.15545329
70Broad ribs (HP:0000885)2.13695832
71Hypsarrhythmia (HP:0002521)2.12741953
72Aortic regurgitation (HP:0001659)2.12457006
73Sleep apnea (HP:0010535)2.09706661
74Failure to thrive in infancy (HP:0001531)2.06640686
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04824894
76Biconcave vertebral bodies (HP:0004586)2.04794128
77Cutaneous finger syndactyly (HP:0010554)2.04303692
78Action tremor (HP:0002345)2.04249396
79Narrow nasal bridge (HP:0000446)2.03030322
80Medial flaring of the eyebrow (HP:0010747)2.01814287
81Wrist flexion contracture (HP:0001239)2.01237685
82Absent eyebrow (HP:0002223)2.00901590
83Birth length less than 3rd percentile (HP:0003561)2.00592301
84Retinal dysplasia (HP:0007973)2.00541530
85Bradycardia (HP:0001662)1.99968473
86Abnormality of skeletal muscle fiber size (HP:0012084)1.99396393
87Genetic anticipation (HP:0003743)1.98626286
88Limb-girdle muscle weakness (HP:0003325)1.98303541
89Mesomelia (HP:0003027)1.93251241
90Limb dystonia (HP:0002451)1.92200792
91Long toe (HP:0010511)1.91550265
92Vertebral compression fractures (HP:0002953)1.90061374
93Camptodactyly of toe (HP:0001836)1.89852687
94Mitral regurgitation (HP:0001653)1.88666646
95Morphological abnormality of the middle ear (HP:0008609)1.88039261
96Megalencephaly (HP:0001355)1.87928563
97Slender long bone (HP:0003100)1.86786377
98Lower limb amyotrophy (HP:0007210)1.86253964
99Genital tract atresia (HP:0001827)1.85918781
100Obstructive sleep apnea (HP:0002870)1.85305318
101Spontaneous hematomas (HP:0007420)1.82951544
102Termporal pattern (HP:0011008)1.82398272
103Insidious onset (HP:0003587)1.82398272
104Congenital primary aphakia (HP:0007707)1.82046226
105Mildly elevated creatine phosphokinase (HP:0008180)1.81461549
106Premature rupture of membranes (HP:0001788)1.81450671
107Scanning speech (HP:0002168)1.81199698
108Vaginal atresia (HP:0000148)1.77852227
109Congenital glaucoma (HP:0001087)1.76720428
110Syringomyelia (HP:0003396)1.76651479
111Spinal cord lesions (HP:0100561)1.76651479
112Shoulder girdle muscle weakness (HP:0003547)1.76180670
113Poor eye contact (HP:0000817)1.75530155
114Bell-shaped thorax (HP:0001591)1.75451222
115Aortic valve stenosis (HP:0001650)1.75158560
116Neoplasm of the adrenal cortex (HP:0100641)1.74416114
117Aplasia involving bones of the upper limbs (HP:0009823)1.73571300
118Aplasia of the phalanges of the hand (HP:0009802)1.73571300
119Aplasia involving bones of the extremities (HP:0009825)1.73571300
120Akinesia (HP:0002304)1.72205887
121Coxa vara (HP:0002812)1.71887796
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71607235
123Hypoplasia of the brainstem (HP:0002365)1.71607235
124Narrow palate (HP:0000189)1.71589744
125Diastasis recti (HP:0001540)1.71433898
126Pheochromocytoma (HP:0002666)1.71178885
127Torticollis (HP:0000473)1.71094204
128Buphthalmos (HP:0000557)1.70746200
129Joint stiffness (HP:0001387)1.70689372
130Truncal ataxia (HP:0002078)1.70581858
131Impaired vibration sensation in the lower limbs (HP:0002166)1.69689173
132Deviation of the hallux (HP:0010051)1.69484865
133Broad long bones (HP:0005622)1.69157190
134Bifid tongue (HP:0010297)1.69046717
135Abnormality of salivation (HP:0100755)1.68924310
136Abnormality of skull ossification (HP:0002703)1.68533446
137Cutaneous syndactyly (HP:0012725)1.67770584
138Abnormality of calcium-phosphate metabolism (HP:0100530)1.67618667
139Hallux valgus (HP:0001822)1.67170288
140Thickened helices (HP:0000391)1.67117980
141Nephrogenic diabetes insipidus (HP:0009806)1.67010860
142Pulmonary artery stenosis (HP:0004415)1.66802823
143Stereotypic behavior (HP:0000733)1.66571316
144Bronchomalacia (HP:0002780)1.66480117
145Neoplasm of the heart (HP:0100544)1.65032048
146Flexion contracture of toe (HP:0005830)1.64051658
147Joint contractures involving the joints of the feet (HP:0100492)1.64051658
148Distal lower limb amyotrophy (HP:0008944)1.63173258
149Deformed tarsal bones (HP:0008119)1.62917677
150Abnormality of incisor morphology (HP:0011063)1.62579843
151Turricephaly (HP:0000262)1.62259226
152Tracheomalacia (HP:0002779)1.62255380
153Absent frontal sinuses (HP:0002688)1.62216538
154Round ear (HP:0100830)1.61755039
155Downturned corners of mouth (HP:0002714)1.61707936
156Congenital sensorineural hearing impairment (HP:0008527)1.61246941
157Bulbous nose (HP:0000414)1.60839436
158Inguinal hernia (HP:0000023)1.59801117
159Nuclear cataract (HP:0100018)1.59727593
160Calcaneovalgus deformity (HP:0001848)1.59573534
161Macroorchidism (HP:0000053)1.59447448
162Asymmetry of the thorax (HP:0001555)1.59399926
163Limited hip movement (HP:0008800)1.59071724
164Thin bony cortex (HP:0002753)1.58413055
165Macroglossia (HP:0000158)1.57664605
166Inappropriate behavior (HP:0000719)1.57492607
167Impaired smooth pursuit (HP:0007772)1.57062946
168Abnormality of the calf musculature (HP:0001430)1.57000960
169Hip dysplasia (HP:0001385)1.55521946
170Abnormality of the corticospinal tract (HP:0002492)1.54719700
171Abnormal eating behavior (HP:0100738)1.54560218
172Round face (HP:0000311)1.54476190
173Specific learning disability (HP:0001328)1.53953233
174Hip contracture (HP:0003273)1.53913746
175Open mouth (HP:0000194)1.53878121
176Thoracolumbar scoliosis (HP:0002944)1.53546375
177Flared iliac wings (HP:0002869)1.53390153
178Dislocated radial head (HP:0003083)1.52827757
179Protruding ear (HP:0000411)1.52825463
180Sensory axonal neuropathy (HP:0003390)1.52751441
181Enlarged kidneys (HP:0000105)1.51873710
182Deeply set eye (HP:0000490)1.51676157
183Coronal craniosynostosis (HP:0004440)1.51640284
184Urinary bladder sphincter dysfunction (HP:0002839)1.51438492
185Abnormality of the phalanges of the hallux (HP:0010057)1.51409057
186Osteolytic defects of the hand bones (HP:0009699)1.50992840
187Osteolytic defects of the phalanges of the hand (HP:0009771)1.50992840
188Lissencephaly (HP:0001339)1.50940576
189Abnormality of polysaccharide metabolism (HP:0011012)1.50317104
190Abnormality of glycosaminoglycan metabolism (HP:0004371)1.50317104
191Abnormality of mucopolysaccharide metabolism (HP:0011020)1.50317104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.08384528
2DDR23.41212099
3NTRK33.07784605
4MAP2K73.05581292
5MARK13.04483563
6AKT32.92379991
7MAP3K42.76466900
8EPHA42.56839768
9MAPK132.53965699
10ACVR1B2.45847720
11DAPK22.19904970
12TGFBR22.14193364
13PRKD32.09543293
14MAP3K122.01763626
15MYLK1.98120237
16MINK11.95012583
17PRPF4B1.92228418
18PRKD21.89490862
19PLK21.74266062
20TNIK1.72294261
21MAP2K41.72012697
22MAP3K91.69648525
23CAMK1D1.65250586
24CDK191.64563547
25RIPK11.60202185
26MOS1.56364285
27NEK91.54011834
28TRIB31.48746856
29STK381.47867168
30ERBB31.46212982
31PAK61.42497305
32CAMKK21.41714166
33PAK21.39584367
34PDGFRB1.38237903
35EPHB11.36345934
36PTK21.36121827
37NTRK11.32371926
38UHMK11.30714356
39OXSR11.30582041
40SGK21.30259906
41CCNB11.29526757
42FER1.29514521
43TTN1.29289400
44LATS11.29081149
45TGFBR11.26032621
46MAP2K31.25817692
47SGK4941.22723025
48SGK2231.22723025
49FRK1.20652545
50BMPR1B1.20544086
51SIK31.12628217
52CDK51.08351472
53BMPR21.07387941
54PNCK1.06725329
55TAOK11.05524121
56NTRK21.03510572
57BCR1.03356779
58MKNK21.03348620
59INSRR1.02233083
60MAP3K71.01742986
61PIK3CG0.98383300
62PAK30.98255494
63LATS20.97344295
64ERN10.97105446
65KSR10.96982670
66GRK50.94568689
67WNK40.92992996
68DYRK1A0.92248934
69CAMK2A0.91705172
70FGFR20.91070546
71PRKCE0.90986341
72MELK0.89642145
73BLK0.89594323
74PRKCG0.89576834
75WNK30.88986470
76MUSK0.88254893
77CAMK2B0.87658080
78STK390.87564136
79KIT0.87200525
80ABL20.85773107
81TYK20.84904919
82YES10.83821042
83DYRK20.83674132
84FES0.82967393
85ADRBK10.81841468
86IRAK40.81193401
87KSR20.80870960
88CAMKK10.80643273
89FGR0.79398473
90DAPK10.78845992
91ADRBK20.78736857
92SGK30.78523895
93PTK2B0.77285841
94PIK3CA0.77031838
95CSNK1G20.76328618
96MAP3K30.76178451
97DMPK0.76096362
98MAP3K20.74570210
99CDK180.74565407
100CDK140.73225066
101PRKCH0.72148100
102WNK10.71028957
103CAMK2D0.70844744
104SIK20.70784141
105CDC42BPA0.70398123
106CAMK10.69823160
107CSK0.67856283
108RPS6KA60.67071661
109EPHA30.66267886
110CDK150.66224271
111STK38L0.63756971
112RPS6KL10.63102854
113RPS6KC10.63102854
114NEK60.62013236
115PDGFRA0.60355644
116MARK20.60202173
117MAP3K60.59368067
118GSK3A0.58716199
119DYRK1B0.58564158
120CLK10.58488135
121CAMK40.57031132
122PRKG20.56876397
123JAK10.56360370
124SIK10.56096718
125CDK11A0.55206371
126CAMK1G0.55004266
127PHKG10.53883688
128PHKG20.53883688
129MTOR0.53684264
130DYRK30.53240024
131NUAK10.52706829
132IRAK20.52173136
133RET0.51937586
134RPS6KA20.50757472
135SGK10.50466832
136GRK70.48783327
137ROCK20.48627166
138CSNK1A1L0.48573458
139ROCK10.48242712
140PRKCZ0.47992293
141PAK40.47584311
142CDK30.46164955
143BRAF0.46151543
144PKN10.43605195
145MAP2K10.43603632
146LIMK10.42381165
147ZAP700.41836139
148STK110.41674808
149EPHB20.41367600
150MAP3K50.40686832
151MAPK70.39399769
152TYRO30.39161022
153HIPK20.38672342

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.94302311
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88243624
3Nicotine addiction_Homo sapiens_hsa050332.85518807
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36762713
5Circadian entrainment_Homo sapiens_hsa047132.33810399
6Insulin secretion_Homo sapiens_hsa049112.33181184
7Olfactory transduction_Homo sapiens_hsa047402.29905769
8Amphetamine addiction_Homo sapiens_hsa050312.14465501
9Morphine addiction_Homo sapiens_hsa050322.13467819
10Glutamatergic synapse_Homo sapiens_hsa047242.09606634
11GABAergic synapse_Homo sapiens_hsa047272.09172140
12Long-term potentiation_Homo sapiens_hsa047202.06999328
13Dopaminergic synapse_Homo sapiens_hsa047282.03281865
14Serotonergic synapse_Homo sapiens_hsa047261.94604902
15Taste transduction_Homo sapiens_hsa047421.90028699
16Cholinergic synapse_Homo sapiens_hsa047251.80635870
17Collecting duct acid secretion_Homo sapiens_hsa049661.80030097
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75872932
19Axon guidance_Homo sapiens_hsa043601.74858283
20Vibrio cholerae infection_Homo sapiens_hsa051101.67453530
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65378784
22Long-term depression_Homo sapiens_hsa047301.61479503
23Renin secretion_Homo sapiens_hsa049241.61391168
24Amoebiasis_Homo sapiens_hsa051461.57210689
25Cocaine addiction_Homo sapiens_hsa050301.54360215
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52050521
27Salivary secretion_Homo sapiens_hsa049701.49437265
28Malaria_Homo sapiens_hsa051441.45407738
29Oxytocin signaling pathway_Homo sapiens_hsa049211.41076422
30Gastric acid secretion_Homo sapiens_hsa049711.37714556
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37557006
32Osteoclast differentiation_Homo sapiens_hsa043801.36414987
33Proteoglycans in cancer_Homo sapiens_hsa052051.35463284
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32300513
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30843465
36Gap junction_Homo sapiens_hsa045401.27692778
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25634975
38ErbB signaling pathway_Homo sapiens_hsa040121.24607612
39GnRH signaling pathway_Homo sapiens_hsa049121.21221336
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20724517
41Calcium signaling pathway_Homo sapiens_hsa040201.19515604
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18127574
43cAMP signaling pathway_Homo sapiens_hsa040241.17202911
44Dilated cardiomyopathy_Homo sapiens_hsa054141.16915290
45Bladder cancer_Homo sapiens_hsa052191.15574101
46Melanogenesis_Homo sapiens_hsa049161.15080008
47Type II diabetes mellitus_Homo sapiens_hsa049301.14347691
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.12997660
49Estrogen signaling pathway_Homo sapiens_hsa049151.10307171
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09193816
51Adherens junction_Homo sapiens_hsa045201.08369882
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.08253080
53Protein export_Homo sapiens_hsa030601.05768008
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.05609010
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04687857
56Lysosome_Homo sapiens_hsa041421.02637295
57Tuberculosis_Homo sapiens_hsa051521.01985275
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01263637
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01171630
60Glioma_Homo sapiens_hsa052140.99491430
61Phototransduction_Homo sapiens_hsa047440.98211650
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96907317
63Wnt signaling pathway_Homo sapiens_hsa043100.96668861
64TNF signaling pathway_Homo sapiens_hsa046680.96252662
65mTOR signaling pathway_Homo sapiens_hsa041500.95220033
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94454383
67Pertussis_Homo sapiens_hsa051330.92557326
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92556567
69TGF-beta signaling pathway_Homo sapiens_hsa043500.92221418
70Salmonella infection_Homo sapiens_hsa051320.91565154
71MicroRNAs in cancer_Homo sapiens_hsa052060.90369421
72Notch signaling pathway_Homo sapiens_hsa043300.90123524
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90103570
74Circadian rhythm_Homo sapiens_hsa047100.89613360
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89430320
76Pathways in cancer_Homo sapiens_hsa052000.89212623
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89199011
78Chronic myeloid leukemia_Homo sapiens_hsa052200.89065157
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89029248
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88469107
81Leishmaniasis_Homo sapiens_hsa051400.88045732
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87864246
83Platelet activation_Homo sapiens_hsa046110.87766829
84MAPK signaling pathway_Homo sapiens_hsa040100.86245257
85Ras signaling pathway_Homo sapiens_hsa040140.84229893
86Dorso-ventral axis formation_Homo sapiens_hsa043200.82333456
87Sulfur metabolism_Homo sapiens_hsa009200.82160142
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80567455
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79737840
90VEGF signaling pathway_Homo sapiens_hsa043700.79423706
91Chemokine signaling pathway_Homo sapiens_hsa040620.79399937
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.78295527
93Endocytosis_Homo sapiens_hsa041440.78083009
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.77428067
95Renal cell carcinoma_Homo sapiens_hsa052110.77379187
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76514191
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74515696
98FoxO signaling pathway_Homo sapiens_hsa040680.74353678
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74095381
100Cardiac muscle contraction_Homo sapiens_hsa042600.73685688
101Hedgehog signaling pathway_Homo sapiens_hsa043400.73379339
102Endometrial cancer_Homo sapiens_hsa052130.73316559
103Pancreatic secretion_Homo sapiens_hsa049720.73029359
104Thyroid hormone synthesis_Homo sapiens_hsa049180.72530044
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72447677
106Melanoma_Homo sapiens_hsa052180.72301359
107Toxoplasmosis_Homo sapiens_hsa051450.71824528
108African trypanosomiasis_Homo sapiens_hsa051430.71625672
109Shigellosis_Homo sapiens_hsa051310.70975776
110Rap1 signaling pathway_Homo sapiens_hsa040150.67331418
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65722926
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64691789
113Glucagon signaling pathway_Homo sapiens_hsa049220.62738093
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.61239020
115Colorectal cancer_Homo sapiens_hsa052100.60126840
116Focal adhesion_Homo sapiens_hsa045100.58669614
117Ovarian steroidogenesis_Homo sapiens_hsa049130.58105443
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57359611
119Rheumatoid arthritis_Homo sapiens_hsa053230.56154675
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55243377
121Phagosome_Homo sapiens_hsa041450.54416277
122Oocyte meiosis_Homo sapiens_hsa041140.52042830
123ECM-receptor interaction_Homo sapiens_hsa045120.52042631
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51326819
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.51153028
126Choline metabolism in cancer_Homo sapiens_hsa052310.51105110
127Hippo signaling pathway_Homo sapiens_hsa043900.50638560
128Alzheimers disease_Homo sapiens_hsa050100.50323327
129Tight junction_Homo sapiens_hsa045300.49848819
130Alcoholism_Homo sapiens_hsa050340.49760111
131Prion diseases_Homo sapiens_hsa050200.47965598
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46641980
133Prostate cancer_Homo sapiens_hsa052150.44463769
134Oxidative phosphorylation_Homo sapiens_hsa001900.43829340
135Insulin signaling pathway_Homo sapiens_hsa049100.43240205
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41941750
137Basal cell carcinoma_Homo sapiens_hsa052170.41488657
138Prolactin signaling pathway_Homo sapiens_hsa049170.39488482
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38956615
140Protein digestion and absorption_Homo sapiens_hsa049740.37766661

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