TSEN34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)4.35544568
2protein maturation by protein folding (GO:0022417)4.23501076
3translational termination (GO:0006415)4.21396195
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.10696634
5formation of translation preinitiation complex (GO:0001731)4.05734931
6translational elongation (GO:0006414)3.98355719
7positive regulation of Cdc42 GTPase activity (GO:0043089)3.96683512
8pyrimidine nucleoside salvage (GO:0043097)3.95361159
9pyrimidine-containing compound salvage (GO:0008655)3.95361159
10DNA deamination (GO:0045006)3.92678165
11pentose-phosphate shunt (GO:0006098)3.91284016
12pentose metabolic process (GO:0019321)3.88850376
13DNA unwinding involved in DNA replication (GO:0006268)3.88393382
14positive regulation by symbiont of host defense response (GO:0052509)3.83110209
15modulation by symbiont of host defense response (GO:0052031)3.83110209
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83110209
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83110209
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.83110209
19modulation by symbiont of host immune response (GO:0052553)3.83110209
20peptidyl-arginine omega-N-methylation (GO:0035247)3.79910764
21maturation of SSU-rRNA (GO:0030490)3.76595251
22virion assembly (GO:0019068)3.75983484
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.73909493
24histone arginine methylation (GO:0034969)3.72471710
25viral protein processing (GO:0019082)3.72134755
26paraxial mesoderm development (GO:0048339)3.69430349
27translational initiation (GO:0006413)3.67749478
28regulation of posttranscriptional gene silencing (GO:0060147)3.64431866
29regulation of gene silencing by miRNA (GO:0060964)3.64431866
30regulation of gene silencing by RNA (GO:0060966)3.64431866
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59675665
32response to peptidoglycan (GO:0032494)3.59269576
33establishment of apical/basal cell polarity (GO:0035089)3.51017555
34polarized epithelial cell differentiation (GO:0030859)3.50430994
35protein targeting to ER (GO:0045047)3.49980243
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49898151
37glucose catabolic process (GO:0006007)3.48973705
38cotranslational protein targeting to membrane (GO:0006613)3.48066212
39GDP-mannose metabolic process (GO:0019673)3.44812031
40guanosine-containing compound biosynthetic process (GO:1901070)3.44421993
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43190144
42viral life cycle (GO:0019058)3.41856599
43cellular protein complex disassembly (GO:0043624)3.40618779
44ribosomal small subunit biogenesis (GO:0042274)3.37821083
45folic acid-containing compound biosynthetic process (GO:0009396)3.34920710
46NADPH regeneration (GO:0006740)3.32682444
47iron-sulfur cluster assembly (GO:0016226)3.31302571
48metallo-sulfur cluster assembly (GO:0031163)3.31302571
49DNA strand elongation involved in DNA replication (GO:0006271)3.31228788
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30844605
51regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.30254029
52protein localization to endoplasmic reticulum (GO:0070972)3.25670860
53amyloid precursor protein catabolic process (GO:0042987)3.23625831
54neutrophil activation involved in immune response (GO:0002283)3.22361028
55protein complex localization (GO:0031503)3.21296458
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20549325
57ATP synthesis coupled proton transport (GO:0015986)3.20549325
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20471093
59protein complex disassembly (GO:0043241)3.19959564
60ribosomal small subunit assembly (GO:0000028)3.17975027
61nucleoside salvage (GO:0043174)3.12488525
62peptidyl-arginine N-methylation (GO:0035246)3.09985362
63peptidyl-arginine methylation (GO:0018216)3.09985362
64spliceosomal snRNP assembly (GO:0000387)3.08904546
65negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.08788596
66GTP biosynthetic process (GO:0006183)3.08597559
67pyrimidine nucleotide catabolic process (GO:0006244)3.07023062
68nucleotide salvage (GO:0043173)3.05931170
69UTP biosynthetic process (GO:0006228)3.05353506
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05079233
71leukocyte aggregation (GO:0070486)3.05013832
72ribosomal large subunit biogenesis (GO:0042273)3.04914699
73cullin deneddylation (GO:0010388)3.04642211
74establishment of monopolar cell polarity (GO:0061162)3.03740761
75establishment or maintenance of monopolar cell polarity (GO:0061339)3.03740761
76nuclear envelope reassembly (GO:0031468)3.03463895
77mitotic nuclear envelope reassembly (GO:0007084)3.03463895
78proteasome assembly (GO:0043248)3.02230377
79establishment of integrated proviral latency (GO:0075713)3.02115782
80DNA strand elongation (GO:0022616)3.01948521
81macromolecular complex disassembly (GO:0032984)3.01867403
82planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01452217
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01353511
84DNA replication-dependent nucleosome organization (GO:0034723)3.01113175
85DNA replication-dependent nucleosome assembly (GO:0006335)3.01113175
86protein retention in ER lumen (GO:0006621)3.00929971
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99105633
88negative regulation of ligase activity (GO:0051352)2.99105633
89mitochondrial calcium ion transport (GO:0006851)2.96674128
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96549383
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95293596
92regulation of translational fidelity (GO:0006450)2.94078527
93nucleobase biosynthetic process (GO:0046112)2.93475116
94negative regulation of cell size (GO:0045792)2.93399600
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92047224
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91267680
97G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.91218196
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88522251
99protein deneddylation (GO:0000338)2.88023644
100interferon-gamma secretion (GO:0072643)2.88007885
101base-excision repair, AP site formation (GO:0006285)2.87987258
102pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87647088
103response to host immune response (GO:0052572)2.87599232
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87599232
105DNA replication initiation (GO:0006270)2.87551828
106translation (GO:0006412)2.87204096
107regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86860807
108respiratory burst (GO:0045730)2.85970158
109response to host defenses (GO:0052200)2.85397059
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85397059
111response to host (GO:0075136)2.85397059
112negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81133378
113de novo protein folding (GO:0006458)2.80070056
114nucleobase-containing small molecule interconversion (GO:0015949)2.79475811
115detection of other organism (GO:0098543)2.78019617
116telomere maintenance via semi-conservative replication (GO:0032201)2.77523719
117spliceosomal complex assembly (GO:0000245)2.77296549
118negative regulation of B cell apoptotic process (GO:0002903)2.76378018
119pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.75940811
120purine nucleobase biosynthetic process (GO:0009113)2.75237875
121detection of bacterium (GO:0016045)2.75033557
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74489444
123regulation of release of cytochrome c from mitochondria (GO:0090199)2.74357707
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73460401
125leukocyte migration involved in inflammatory response (GO:0002523)2.72206962
126ribonucleoprotein complex biogenesis (GO:0022613)2.72045579
127UV protection (GO:0009650)2.71865094
128oxidative phosphorylation (GO:0006119)2.71428756
129lung-associated mesenchyme development (GO:0060484)2.71095266
130de novo posttranslational protein folding (GO:0051084)2.70500229
131CTP metabolic process (GO:0046036)2.70499470
132CTP biosynthetic process (GO:0006241)2.70499470
133pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.70273103
134regulation of hippo signaling (GO:0035330)2.70009998
135antigen processing and presentation of endogenous antigen (GO:0019883)2.69824249
136positive regulation of actin cytoskeleton reorganization (GO:2000251)2.69452438
137proline biosynthetic process (GO:0006561)2.67859288
138negative regulation of microtubule polymerization (GO:0031115)2.67212502
139deoxyribonucleotide catabolic process (GO:0009264)2.65490874
140positive regulation of gastrulation (GO:2000543)2.64696059
141ribosome assembly (GO:0042255)2.64164298
142mitotic metaphase plate congression (GO:0007080)2.62864727
143lung morphogenesis (GO:0060425)2.62803369
144UTP metabolic process (GO:0046051)2.61533245
145positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.61194552
146regulation of protein heterodimerization activity (GO:0043497)2.61066991
147negative regulation of RNA splicing (GO:0033119)2.60705208
148deoxyribose phosphate catabolic process (GO:0046386)2.59665940
149positive regulation of ligase activity (GO:0051351)2.57934904
150mitotic G1 DNA damage checkpoint (GO:0031571)2.57674957
151Golgi transport vesicle coating (GO:0048200)2.57085908
152COPI coating of Golgi vesicle (GO:0048205)2.57085908
153nodal signaling pathway (GO:0038092)2.56661132
154GMP metabolic process (GO:0046037)2.55665344
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.55580868
156pseudouridine synthesis (GO:0001522)2.55090103
157protein insertion into membrane (GO:0051205)2.54584618
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54139629
159maternal placenta development (GO:0001893)2.53868712
160regulation of superoxide anion generation (GO:0032928)2.53786090
161NADP metabolic process (GO:0006739)2.53773330
162positive regulation of T cell apoptotic process (GO:0070234)2.52751751
163positive regulation of mitochondrial fission (GO:0090141)2.52665337
164epithelial cell-cell adhesion (GO:0090136)2.51930693
165neutrophil activation (GO:0042119)2.51849974
166regulation of ubiquitin-protein transferase activity (GO:0051438)2.51207837
167regulation of mast cell degranulation (GO:0043304)2.50999309
168IMP biosynthetic process (GO:0006188)2.47667496
169regulation of mitochondrial translation (GO:0070129)2.46993686
170deoxyribose phosphate biosynthetic process (GO:0046385)2.46522051
171DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44860849
172protein targeting to membrane (GO:0006612)2.44852452
173establishment of protein localization to mitochondrial membrane (GO:0090151)2.43911380
174ribosome biogenesis (GO:0042254)2.43782340
175nuclear-transcribed mRNA catabolic process (GO:0000956)2.42184482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.19690924
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.99197020
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91509980
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45103104
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97587056
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65550252
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.59799308
8VDR_21846776_ChIP-Seq_THP-1_Human2.57458285
9XRN2_22483619_ChIP-Seq_HELA_Human2.49043187
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.44686840
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38621890
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.37690065
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.30842275
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26240551
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23049079
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19686935
17E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06975659
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05468460
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03911630
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01236752
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00504707
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.00041884
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.98538072
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98535621
25* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.91402902
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87798175
27* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87491282
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83698531
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83553889
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82359963
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80601418
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74154232
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73516401
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72527589
35* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.72047813
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71991626
37TTF2_22483619_ChIP-Seq_HELA_Human1.69333818
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66369939
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65843563
40P68_20966046_ChIP-Seq_HELA_Human1.65140296
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64553505
42* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61780089
43* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60532935
44DCP1A_22483619_ChIP-Seq_HELA_Human1.60013027
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59267135
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57488502
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57184499
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55441870
49GABP_19822575_ChIP-Seq_HepG2_Human1.55113159
50OCT4_18692474_ChIP-Seq_MEFs_Mouse1.54051810
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51492992
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50429543
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50360735
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49408944
55BCL6_27268052_Chip-Seq_Bcells_Human1.49099603
56SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48178837
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46722404
58* ELF1_20517297_ChIP-Seq_JURKAT_Human1.46549334
59ZNF263_19887448_ChIP-Seq_K562_Human1.44978962
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44026534
61* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42763617
62AR_21909140_ChIP-Seq_LNCAP_Human1.41051093
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.38475063
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.37655150
65* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36913215
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36632405
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35582492
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.35545958
69* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34546891
70* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33055961
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32377056
72SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31863241
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30281557
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30281557
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30281557
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29853909
77BCOR_27268052_Chip-Seq_Bcells_Human1.29482300
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28856064
79* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28851757
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28255594
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26988017
82* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26952094
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26874709
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.25975541
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.25654213
86CLOCK_20551151_ChIP-Seq_293T_Human1.25454117
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25241553
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25089021
89VDR_24763502_ChIP-Seq_THP-1_Human1.24451678
90* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.23907542
91MAF_26560356_Chip-Seq_TH2_Human1.23556192
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23295658
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21958336
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21887846
95KDM2B_26808549_Chip-Seq_DND41_Human1.20035077
96KDM5A_27292631_Chip-Seq_BREAST_Human1.19321675
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18685896
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18169599
99* SPI1_23547873_ChIP-Seq_NB4_Human1.17205574
100ATF3_27146783_Chip-Seq_COLON_Human1.16484692
101* LXR_22292898_ChIP-Seq_THP-1_Human1.16271071
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15946996
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15384594
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14813748
105MAF_26560356_Chip-Seq_TH1_Human1.14772625
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.14618512
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.14147203
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13935031
109PHF8_20622854_ChIP-Seq_HELA_Human1.13305982
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13296225
111UTX_26944678_Chip-Seq_JUKART_Human1.12923721
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.12693347
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12221065
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11285362
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10691212
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10195920
117SMC4_20622854_ChIP-Seq_HELA_Human1.10128596
118* E2F1_20622854_ChIP-Seq_HELA_Human1.09594376
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.09393002
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09385855
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09277798
122CIITA_25753668_ChIP-Seq_RAJI_Human1.08183720
123CTCF_21964334_Chip-Seq_Bcells_Human1.08094054
124* VDR_23849224_ChIP-Seq_CD4+_Human1.07806184
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07526982
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07522804
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06456900
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06289093
129RARB_24833708_ChIP-Seq_LIVER_Mouse1.05794925
130RACK7_27058665_Chip-Seq_MCF-7_Human1.05634125
131TCF7_22412390_ChIP-Seq_EML_Mouse1.05005845
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04864387
133TP53_20018659_ChIP-ChIP_R1E_Mouse1.04851798
134TFEB_21752829_ChIP-Seq_HELA_Human1.04647540
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04583144
136MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03555995
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03522495
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02778801
139MYC_22102868_ChIP-Seq_BL_Human1.00225725
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00103221
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99786184
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.99519515
143NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99158557
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97994943
145SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97059371
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95587779
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.95435953
148SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94697201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.11528391
2MP0008260_abnormal_autophagy4.11519975
3MP0003283_abnormal_digestive_organ3.22084038
4MP0003705_abnormal_hypodermis_morpholog3.04137885
5MP0003436_decreased_susceptibility_to3.02766512
6MP0003191_abnormal_cellular_cholesterol3.01992035
7MP0003123_paternal_imprinting2.96712523
8MP0003693_abnormal_embryo_hatching2.85686769
9MP0005451_abnormal_body_composition2.80932437
10MP0000537_abnormal_urethra_morphology2.78087294
11MP0004957_abnormal_blastocyst_morpholog2.72794555
12MP0003119_abnormal_digestive_system2.65749299
13MP0005058_abnormal_lysosome_morphology2.56751850
14MP0009278_abnormal_bone_marrow2.56749574
15MP0003724_increased_susceptibility_to2.50255581
16MP0004133_heterotaxia2.42339249
17MP0008438_abnormal_cutaneous_collagen2.35381252
18MP0002132_abnormal_respiratory_system2.10662441
19MP0008932_abnormal_embryonic_tissue2.08900931
20MP0003122_maternal_imprinting2.08593442
21MP0000858_altered_metastatic_potential1.98776118
22MP0003111_abnormal_nucleus_morphology1.97608053
23MP0009053_abnormal_anal_canal1.96060416
24MP0010352_gastrointestinal_tract_polyps1.93721661
25MP0003077_abnormal_cell_cycle1.87547979
26MP0001730_embryonic_growth_arrest1.85918376
27MP0004272_abnormal_basement_membrane1.85217610
28MP0002653_abnormal_ependyma_morphology1.82935108
29MP0000049_abnormal_middle_ear1.82420036
30MP0003303_peritoneal_inflammation1.81875247
31MP0000750_abnormal_muscle_regeneration1.80949636
32MP0003186_abnormal_redox_activity1.80739243
33MP0002877_abnormal_melanocyte_morpholog1.77478915
34MP0004233_abnormal_muscle_weight1.76968900
35MP0000490_abnormal_crypts_of1.73956526
36MP0002234_abnormal_pharynx_morphology1.70836280
37MP0003942_abnormal_urinary_system1.69774389
38MP0005275_abnormal_skin_tensile1.67370715
39MP0002084_abnormal_developmental_patter1.60108524
40MP0000534_abnormal_ureter_morphology1.59883142
41MP0002085_abnormal_embryonic_tissue1.58383449
42MP0000465_gastrointestinal_hemorrhage1.56845552
43MP0003279_aneurysm1.56298655
44MP0002419_abnormal_innate_immunity1.55783225
45MP0001697_abnormal_embryo_size1.51723511
46MP0003183_abnormal_peptide_metabolism1.45603770
47MP0008007_abnormal_cellular_replicative1.43991691
48MP0005025_abnormal_response_to1.43880543
49MP0004197_abnormal_fetal_growth/weight/1.43669204
50MP0003385_abnormal_body_wall1.42938363
51MP0002277_abnormal_respiratory_mucosa1.42529630
52MP0009840_abnormal_foam_cell1.40513760
53MP0001533_abnormal_skeleton_physiology1.40417375
54MP0003941_abnormal_skin_development1.40413715
55MP0000462_abnormal_digestive_system1.39871772
56MP0004084_abnormal_cardiac_muscle1.36091764
57MP0009333_abnormal_splenocyte_physiolog1.35778496
58MP0003567_abnormal_fetal_cardiomyocyte1.33925729
59MP0002282_abnormal_trachea_morphology1.33795678
60MP0005503_abnormal_tendon_morphology1.33782516
61MP0000350_abnormal_cell_proliferation1.32633660
62MP0002932_abnormal_joint_morphology1.30368564
63MP0000681_abnormal_thyroid_gland1.30297880
64MP0002111_abnormal_tail_morphology1.29983059
65MP0000751_myopathy1.29313542
66MP0002080_prenatal_lethality1.29127599
67MP0003890_abnormal_embryonic-extraembry1.27886971
68MP0004858_abnormal_nervous_system1.26529786
69MP0005380_embryogenesis_phenotype1.26452203
70MP0001672_abnormal_embryogenesis/_devel1.26452203
71MP0010094_abnormal_chromosome_stability1.26395760
72MP0001849_ear_inflammation1.25571430
73MP0002249_abnormal_larynx_morphology1.24762263
74MP0001542_abnormal_bone_strength1.23175665
75MP0003115_abnormal_respiratory_system1.21469223
76MP0001545_abnormal_hematopoietic_system1.20963165
77MP0005397_hematopoietic_system_phenotyp1.20963165
78MP0003121_genomic_imprinting1.19580219
79MP0004185_abnormal_adipocyte_glucose1.19417210
80MP0005464_abnormal_platelet_physiology1.19050935
81MP0005623_abnormal_meninges_morphology1.18979964
82MP0003315_abnormal_perineum_morphology1.18943904
83MP0003566_abnormal_cell_adhesion1.18938808
84MP0000428_abnormal_craniofacial_morphol1.18460840
85MP0001293_anophthalmia1.16749990
86MP0000678_abnormal_parathyroid_gland1.15016340
87MP0002751_abnormal_autonomic_nervous1.13483642
88MP0006035_abnormal_mitochondrial_morpho1.12580004
89MP0002088_abnormal_embryonic_growth/wei1.12475350
90MP0003984_embryonic_growth_retardation1.12467777
91MP0003866_abnormal_defecation1.12294775
92MP0002796_impaired_skin_barrier1.11818411
93MP0009785_altered_susceptibility_to1.11797609
94MP0005083_abnormal_biliary_tract1.11481359
95MP0003786_premature_aging1.09585305
96MP0005377_hearing/vestibular/ear_phenot1.07812363
97MP0003878_abnormal_ear_physiology1.07812363
98MP0000358_abnormal_cell_content/1.07471324
99MP0002269_muscular_atrophy1.07156577
100MP0009764_decreased_sensitivity_to1.06005603
101MP0002086_abnormal_extraembryonic_tissu1.05424843
102MP0002089_abnormal_postnatal_growth/wei1.05300074
103MP0008469_abnormal_protein_level1.04178161
104MP0003806_abnormal_nucleotide_metabolis1.03023172
105MP0000013_abnormal_adipose_tissue1.02973248
106MP0003937_abnormal_limbs/digits/tail_de1.01976804
107MP0006054_spinal_hemorrhage1.01662509
108MP0000015_abnormal_ear_pigmentation1.01630716
109MP0002938_white_spotting1.01523414
110MP0009379_abnormal_foot_pigmentation1.01294267
111MP0000762_abnormal_tongue_morphology0.98599317
112MP0005023_abnormal_wound_healing0.98554969
113MP0002822_catalepsy0.98446345
114MP0002098_abnormal_vibrissa_morphology0.98070890
115MP0000343_altered_response_to0.98051158
116MP0005319_abnormal_enzyme/_coenzyme0.96930904
117MP0005390_skeleton_phenotype0.96919971
118MP0005508_abnormal_skeleton_morphology0.96694168
119MP0003453_abnormal_keratinocyte_physiol0.95554203
120MP0005084_abnormal_gallbladder_morpholo0.95125218
121MP0003861_abnormal_nervous_system0.94816501
122MP0001819_abnormal_immune_cell0.94747678
123MP0002420_abnormal_adaptive_immunity0.94706270
124MP0002723_abnormal_immune_serum0.94628341
125MP0005330_cardiomyopathy0.93950427
126MP0005076_abnormal_cell_differentiation0.92936714
127MP0003755_abnormal_palate_morphology0.92069402
128MP0003935_abnormal_craniofacial_develop0.90843958
129MP0004947_skin_inflammation0.88287104
130MP0001764_abnormal_homeostasis0.87596238
131MP0003172_abnormal_lysosome_physiology0.87363789
132MP0003075_altered_response_to0.87049994
133MP0000467_abnormal_esophagus_morphology0.86513643
134MP0004381_abnormal_hair_follicle0.86050684
135MP0001845_abnormal_inflammatory_respons0.85801891
136MP0002697_abnormal_eye_size0.84833147
137MP0003137_abnormal_impulse_conducting0.84798856
138MP0002116_abnormal_craniofacial_bone0.83215000
139MP0003011_delayed_dark_adaptation0.82185438
140MP0002092_abnormal_eye_morphology0.80585267
141MP0002452_abnormal_antigen_presenting0.80340589
142MP0006036_abnormal_mitochondrial_physio0.79095244
143MP0002148_abnormal_hypersensitivity_rea0.78723124
144MP0000313_abnormal_cell_death0.78628367
145MP0002114_abnormal_axial_skeleton0.78590599
146MP0002019_abnormal_tumor_incidence0.77506258
147MP0003221_abnormal_cardiomyocyte_apopto0.76972479
148MP0002429_abnormal_blood_cell0.76513811
149MP0000613_abnormal_salivary_gland0.76468155
150MP0002127_abnormal_cardiovascular_syste0.75351349
151MP0005501_abnormal_skin_physiology0.74345572
152MP0002928_abnormal_bile_duct0.74042702
153MP0006072_abnormal_retinal_apoptosis0.73629521
154MP0009250_abnormal_appendicular_skeleto0.72401516
155MP0005257_abnormal_intraocular_pressure0.72299798
156MP0000566_synostosis0.72227993
157MP0003828_pulmonary_edema0.72094405
158MP0005000_abnormal_immune_tolerance0.72059016
159MP0000516_abnormal_urinary_system0.71612329
160MP0005367_renal/urinary_system_phenotyp0.71612329
161MP0009672_abnormal_birth_weight0.70857635
162MP0010234_abnormal_vibrissa_follicle0.70654213
163MP0000716_abnormal_immune_system0.70561281
164MP0001727_abnormal_embryo_implantation0.69630105
165MP0005187_abnormal_penis_morphology0.69056112
166MP0005248_abnormal_Harderian_gland0.68567247
167MP0000733_abnormal_muscle_development0.68052245
168MP0005409_darkened_coat_color0.67602566
169MP0006292_abnormal_olfactory_placode0.67320260
170MP0009384_cardiac_valve_regurgitation0.67300140
171MP0002722_abnormal_immune_system0.66601935
172MP0010155_abnormal_intestine_physiology0.66492754

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.24293317
2Ragged-red muscle fibers (HP:0003200)3.44415503
3Recurrent abscess formation (HP:0002722)3.41701917
4Myositis (HP:0100614)3.40986183
5Selective tooth agenesis (HP:0001592)3.37045126
6Eczematoid dermatitis (HP:0000976)3.23281659
7Recurrent bacterial skin infections (HP:0005406)3.14610026
8Elevated erythrocyte sedimentation rate (HP:0003565)3.11916824
9Chronic obstructive pulmonary disease (HP:0006510)3.08441592
10Obstructive lung disease (HP:0006536)3.08441592
11Abnormality of macrophages (HP:0004311)3.06291548
12Orchitis (HP:0100796)3.01838603
13Premature rupture of membranes (HP:0001788)3.01254700
14Microvesicular hepatic steatosis (HP:0001414)2.98378628
15Multiple enchondromatosis (HP:0005701)2.97542809
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91515377
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91515377
18Abnormality of the distal phalanges of the toes (HP:0010182)2.91159892
19Prolonged neonatal jaundice (HP:0006579)2.89916337
20Hypertensive crisis (HP:0100735)2.88435135
21Ependymoma (HP:0002888)2.88391472
22Colon cancer (HP:0003003)2.81774283
23Trismus (HP:0000211)2.77263507
24Peritonitis (HP:0002586)2.74962469
25Ankle contracture (HP:0006466)2.71484099
26Shallow orbits (HP:0000586)2.61676608
27Petechiae (HP:0000967)2.60591258
28Angiofibromas (HP:0010615)2.56755284
29Adenoma sebaceum (HP:0009720)2.56755284
30Missing ribs (HP:0000921)2.56510498
31Renal duplication (HP:0000075)2.53884004
32Broad distal phalanx of finger (HP:0009836)2.52364125
33Urticaria (HP:0001025)2.51517214
34Hepatosplenomegaly (HP:0001433)2.43103885
35Microretrognathia (HP:0000308)2.38544030
36Mediastinal lymphadenopathy (HP:0100721)2.38050813
37Abnormal mitochondria in muscle tissue (HP:0008316)2.36587224
38Growth hormone excess (HP:0000845)2.35986426
39Short nail (HP:0001799)2.35359518
40Abnormality of dentin (HP:0010299)2.31177742
41Slender long bone (HP:0003100)2.30496321
42Recurrent gram-negative bacterial infections (HP:0005420)2.27397861
43Abnormality of the aortic arch (HP:0012303)2.26530354
44Bladder diverticulum (HP:0000015)2.24912530
45Micronodular cirrhosis (HP:0001413)2.24806776
46Abnormality of cells of the erythroid lineage (HP:0012130)2.24178713
47Hepatocellular necrosis (HP:0001404)2.23781669
48Breast hypoplasia (HP:0003187)2.23715163
49Reticulocytopenia (HP:0001896)2.22204863
50Testicular atrophy (HP:0000029)2.20712053
51Long palpebral fissure (HP:0000637)2.19580037
52Increased muscle lipid content (HP:0009058)2.17126805
53Soft skin (HP:0000977)2.15982021
54Cerebral aneurysm (HP:0004944)2.14804067
55Increased IgM level (HP:0003496)2.13477577
56Hand muscle atrophy (HP:0009130)2.12198982
57Degeneration of anterior horn cells (HP:0002398)2.11906283
58Abnormality of the anterior horn cell (HP:0006802)2.11906283
59Mesangial abnormality (HP:0001966)2.09537801
60Hyperthyroidism (HP:0000836)2.07860963
61Purpura (HP:0000979)2.07256456
62Abnormality of liposaccharide metabolism (HP:0010968)2.06989561
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.06989561
64Abnormality of glycolipid metabolism (HP:0010969)2.06989561
65Progressive muscle weakness (HP:0003323)2.05676713
66Bowel diverticulosis (HP:0005222)2.05002616
67Pallor (HP:0000980)2.00633310
68Shoulder girdle muscle weakness (HP:0003547)2.00457482
69Atelectasis (HP:0100750)2.00244462
70Limb-girdle muscle atrophy (HP:0003797)1.99743017
71Increased intramyocellular lipid droplets (HP:0012240)1.99658807
72Mitochondrial inheritance (HP:0001427)1.98979433
73Patellar aplasia (HP:0006443)1.98863626
74Difficulty climbing stairs (HP:0003551)1.98286582
75Gastrointestinal infarctions (HP:0005244)1.97696525
76Cellulitis (HP:0100658)1.97609477
77Vertebral compression fractures (HP:0002953)1.97054263
78Maternal diabetes (HP:0009800)1.96721179
79Aplasia/Hypoplasia of the patella (HP:0006498)1.95273260
80Abnormality of the fetal cardiovascular system (HP:0010948)1.95233438
81Abnormal umbilical cord blood vessels (HP:0011403)1.95233438
82Single umbilical artery (HP:0001195)1.95233438
83Abnormality of the peritoneum (HP:0002585)1.94659853
84Optic neuritis (HP:0100653)1.93940132
85Retrobulbar optic neuritis (HP:0100654)1.93940132
86Hyperparathyroidism (HP:0000843)1.92430095
87Neoplasm of the pancreas (HP:0002894)1.92201436
88Abdominal situs inversus (HP:0003363)1.89726883
89Abnormality of abdominal situs (HP:0011620)1.89726883
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88618665
91Abnormal enzyme/coenzyme activity (HP:0012379)1.88459472
92Astrocytoma (HP:0009592)1.88151217
93Abnormality of the astrocytes (HP:0100707)1.88151217
94Hyperacusis (HP:0010780)1.87353782
95Recurrent skin infections (HP:0001581)1.86527590
96Patent foramen ovale (HP:0001655)1.86488796
97Hypokinesia (HP:0002375)1.85828772
98Abnormality of alkaline phosphatase activity (HP:0004379)1.85491652
99Episodic fever (HP:0001954)1.85455080
100Hepatic necrosis (HP:0002605)1.85039514
101Pelvic girdle muscle weakness (HP:0003749)1.83708921
102Abnormal hemoglobin (HP:0011902)1.83447675
103Flattened epiphyses (HP:0003071)1.83197351
104Anorexia (HP:0002039)1.83183187
105Fragile skin (HP:0001030)1.82804514
106Cerebral hypomyelination (HP:0006808)1.82790792
107Abnormality of the Achilles tendon (HP:0005109)1.81991444
108Oral leukoplakia (HP:0002745)1.81792177
109Amyloidosis (HP:0011034)1.81586809
110Interstitial pulmonary disease (HP:0006530)1.81332596
111Distal upper limb amyotrophy (HP:0007149)1.81202010
112Upper limb amyotrophy (HP:0009129)1.81202010
113Biconcave vertebral bodies (HP:0004586)1.81015378
114Increased serum ferritin (HP:0003281)1.80767923
115Abnormality of the umbilical cord (HP:0010881)1.80542721
116Hypochromic anemia (HP:0001931)1.80388156
117Increased IgE level (HP:0003212)1.80372603
118Genu recurvatum (HP:0002816)1.80097164
119Anomalous pulmonary venous return (HP:0010772)1.79757260
120Wrist flexion contracture (HP:0001239)1.79288261
12111 pairs of ribs (HP:0000878)1.79263353
122Intestinal polyp (HP:0005266)1.77719653
123Adducted thumb (HP:0001181)1.77506499
124Short 4th metacarpal (HP:0010044)1.76936262
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76936262
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76306300
127Carpal bone hypoplasia (HP:0001498)1.76152714
128Concave nail (HP:0001598)1.75966865
129Aplasia/hypoplasia of the humerus (HP:0006507)1.75355396
130Medulloblastoma (HP:0002885)1.74746026
131Blue sclerae (HP:0000592)1.73964099
132Progressive neurologic deterioration (HP:0002344)1.73889779
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.73841967
134Acute hepatic failure (HP:0006554)1.73177069
135Gastrointestinal inflammation (HP:0004386)1.72078809
136Thin bony cortex (HP:0002753)1.71717385
137Abnormal number of erythroid precursors (HP:0012131)1.71324961
138Acute necrotizing encephalopathy (HP:0006965)1.69864813
139Flat capital femoral epiphysis (HP:0003370)1.69617210
140Intestinal polyposis (HP:0200008)1.68740027
141Gingivitis (HP:0000230)1.68697594
142Truncus arteriosus (HP:0001660)1.68367245
143Broad metatarsal (HP:0001783)1.67807394
144Elevated alkaline phosphatase (HP:0003155)1.67471263
145Shawl scrotum (HP:0000049)1.67315211
146Distal lower limb muscle weakness (HP:0009053)1.67140204
147Hypercortisolism (HP:0001578)1.67104727
148Turricephaly (HP:0000262)1.66374704
149Exercise intolerance (HP:0003546)1.65413962
150Hypercalcemia (HP:0003072)1.63478348
151Fasciculations (HP:0002380)1.62749032
152Hypoparathyroidism (HP:0000829)1.62474293
153Entropion (HP:0000621)1.62193638
154Lactic acidosis (HP:0003128)1.62091030
155Atrophic scars (HP:0001075)1.62082852
156Lymphangioma (HP:0100764)1.61486162
157Abnormality of the 4th metacarpal (HP:0010012)1.61392156
158Late onset (HP:0003584)1.61314584
159Glossoptosis (HP:0000162)1.61199700
160Hyperextensible skin (HP:0000974)1.61031420
161Rough bone trabeculation (HP:0100670)1.60352291
162Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.59371414
163Vertebral hypoplasia (HP:0008417)1.59371414
164Coronal craniosynostosis (HP:0004440)1.59247238
165Back pain (HP:0003418)1.57589603
166Achilles tendon contracture (HP:0001771)1.57384649
167Abnormality of the musculature of the pelvis (HP:0001469)1.56752689
168Abnormality of the hip-girdle musculature (HP:0001445)1.56752689
169Fused cervical vertebrae (HP:0002949)1.56213737
170Rib fusion (HP:0000902)1.56177718
171Macrocytic anemia (HP:0001972)1.54712868
172Atresia of the external auditory canal (HP:0000413)1.53900962
173Neoplasm of the heart (HP:0100544)1.53210724
174Congenital glaucoma (HP:0001087)1.53159723
175Fibroma (HP:0010614)1.52768252
176Absent radius (HP:0003974)1.51734663
177Broad toe (HP:0001837)1.51352569
178Emotional lability (HP:0000712)1.51163521
179Increased serum pyruvate (HP:0003542)1.50296146
180Abnormality of glycolysis (HP:0004366)1.50296146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.87868830
2LATS23.00329007
3WEE12.98949925
4TRIB32.81252061
5EPHA22.81026377
6NEK12.51970878
7MAP2K32.51187409
8IRAK42.35571293
9TESK22.34439099
10SMG12.27348813
11SIK12.22287181
12TESK12.18652053
13IRAK32.13860993
14VRK22.12711816
15PAK42.10995089
16DYRK31.99265333
17MAP3K111.93682202
18ERN11.91430376
19LIMK11.90246021
20NME21.87101709
21EPHB11.75486192
22PKN21.68355915
23MAPKAPK31.66148868
24PRKD21.64329167
25EPHB21.62893611
26GRK61.60858567
27MAP3K101.58952374
28PASK1.54586079
29SCYL21.50249084
30RPS6KA41.49539079
31DYRK21.47936676
32KSR21.47057627
33BCKDK1.46150050
34CDC71.45368545
35DDR21.43159803
36NEK21.42304437
37KDR1.42236910
38RPS6KB21.39896049
39PDGFRA1.39540611
40IRAK21.37910005
41LMTK21.36405363
42CDK191.30686533
43AURKA1.28461761
44KSR11.21941569
45MAP3K91.21848288
46UHMK11.19249016
47MAP3K81.15062949
48WNK31.14699385
49TTN1.13397910
50CDK71.11874183
51MAP4K11.11839871
52TTK1.10603838
53TYK21.10062462
54PLK11.09828921
55ILK1.09744300
56PTK21.08092726
57FER1.03938536
58TGFBR11.02999819
59MAP3K61.01536941
60TBK11.00668736
61PAK10.99803883
62EIF2AK10.99479284
63MAP2K20.95305670
64LRRK20.94979308
65MAP2K40.93482476
66DYRK1B0.93334052
67EEF2K0.93224102
68TNK20.91730430
69IRAK10.89073098
70PRPF4B0.88482329
71SIK30.88032366
72RIPK10.86959830
73CDK80.86039513
74AURKB0.85450188
75FGFR10.82371627
76CDK140.81391214
77MAP3K10.79258205
78BRSK10.78598405
79PAK60.77839787
80MINK10.77517837
81MST1R0.77439822
82PAK30.75998905
83MET0.74902942
84CSK0.74897078
85PHKG20.74035967
86PHKG10.74035967
87BRAF0.73962978
88STK38L0.73621762
89ACVR1B0.71624795
90CDK150.69990360
91CDK11A0.69861524
92DAPK30.69726391
93PRKCI0.69579643
94PTK60.69155878
95CDK180.68738550
96PAK20.68467687
97JAK30.66992332
98RPS6KL10.66658482
99RPS6KC10.66658482
100ICK0.66334803
101MTOR0.65625424
102STK160.65609116
103MAP2K70.62409077
104MAP3K120.61383166
105ARAF0.61362201
106MAP2K10.61303099
107PIM20.61116425
108STK100.60777839
109NTRK10.60570885
110AKT20.59638540
111CHEK20.58942003
112MARK20.58627506
113IKBKB0.58437450
114TLK10.58087965
115RAF10.57473246
116STK380.57247144
117ABL20.56943010
118RPS6KA20.55134878
119RPS6KA60.54497076
120FGR0.54193491
121MAP3K50.54155522
122PDPK10.53647929
123MATK0.52979826
124BLK0.51968773
125FLT30.50535717
126MAPKAPK20.50167214
127TAOK20.49691000
128NME10.48281111
129MARK10.47172214
130PRKG20.47136899
131ATR0.46865698
132BCR0.46369330
133TSSK60.45946194
134TAOK10.45526834
135CSF1R0.45168582
136TYRO30.44359626
137CSNK1G30.44145332
138MAP3K20.43789495
139MYLK0.43616575
140MOS0.43580826
141CDK90.43187775
142MAP3K30.42602471
143ALK0.42531099
144HCK0.42220308
145CDK40.42063606
146PRKD30.41106096
147ERBB30.40950538
148ZAP700.38408699
149RIPK40.37178705
150RPS6KA10.34677189
151SIK20.34332892
152CAMK2G0.34235503
153MAPK110.33823728

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.13101855
2Proteasome_Homo sapiens_hsa030503.69788153
3DNA replication_Homo sapiens_hsa030303.65599037
4Mismatch repair_Homo sapiens_hsa034303.15458403
5Spliceosome_Homo sapiens_hsa030402.97806953
6RNA transport_Homo sapiens_hsa030132.35834197
7RNA polymerase_Homo sapiens_hsa030202.28493526
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23056348
9Base excision repair_Homo sapiens_hsa034102.21307849
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18378880
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13326420
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05975022
13Basal cell carcinoma_Homo sapiens_hsa052171.99955786
14Pyrimidine metabolism_Homo sapiens_hsa002401.88281776
15Cell cycle_Homo sapiens_hsa041101.85579905
16Hippo signaling pathway_Homo sapiens_hsa043901.82890694
17Nucleotide excision repair_Homo sapiens_hsa034201.82643878
18Parkinsons disease_Homo sapiens_hsa050121.80398294
19Hedgehog signaling pathway_Homo sapiens_hsa043401.72975838
20Other glycan degradation_Homo sapiens_hsa005111.65762338
21Oxidative phosphorylation_Homo sapiens_hsa001901.62506248
22Biosynthesis of amino acids_Homo sapiens_hsa012301.56155990
23One carbon pool by folate_Homo sapiens_hsa006701.55123409
24Bladder cancer_Homo sapiens_hsa052191.53200861
25Homologous recombination_Homo sapiens_hsa034401.51991766
26Acute myeloid leukemia_Homo sapiens_hsa052211.50806510
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47102613
28Huntingtons disease_Homo sapiens_hsa050161.37979041
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.35565222
30Osteoclast differentiation_Homo sapiens_hsa043801.31998346
31Sulfur relay system_Homo sapiens_hsa041221.31037539
32p53 signaling pathway_Homo sapiens_hsa041151.29977569
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29148005
34Carbon metabolism_Homo sapiens_hsa012001.28727580
35Folate biosynthesis_Homo sapiens_hsa007901.24036601
36Thyroid cancer_Homo sapiens_hsa052161.23670546
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23186868
38Leishmaniasis_Homo sapiens_hsa051401.19547777
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19390261
40Cardiac muscle contraction_Homo sapiens_hsa042601.17747866
41Salmonella infection_Homo sapiens_hsa051321.16575147
42Non-small cell lung cancer_Homo sapiens_hsa052231.16396225
43Oocyte meiosis_Homo sapiens_hsa041141.12041507
44mRNA surveillance pathway_Homo sapiens_hsa030151.11289494
45Chronic myeloid leukemia_Homo sapiens_hsa052201.09877759
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09099266
47Pancreatic cancer_Homo sapiens_hsa052121.08576075
48Phagosome_Homo sapiens_hsa041451.06510971
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.05192127
50Legionellosis_Homo sapiens_hsa051341.04427746
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03895290
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03503708
53Sulfur metabolism_Homo sapiens_hsa009201.03017885
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02243918
55TGF-beta signaling pathway_Homo sapiens_hsa043501.00846451
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99244350
57Tight junction_Homo sapiens_hsa045300.99189955
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97582529
59Lysosome_Homo sapiens_hsa041420.97088473
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96143425
61Apoptosis_Homo sapiens_hsa042100.96132876
62Tuberculosis_Homo sapiens_hsa051520.94973296
63Endocytosis_Homo sapiens_hsa041440.93180588
64Hepatitis C_Homo sapiens_hsa051600.92513656
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91465916
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91429378
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90659286
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.88859566
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86894069
70Alzheimers disease_Homo sapiens_hsa050100.86837068
71Steroid biosynthesis_Homo sapiens_hsa001000.84015716
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83319936
73Glutathione metabolism_Homo sapiens_hsa004800.81736340
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81460001
75Notch signaling pathway_Homo sapiens_hsa043300.81206254
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.80644324
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79823323
78N-Glycan biosynthesis_Homo sapiens_hsa005100.79597170
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79218678
80Fructose and mannose metabolism_Homo sapiens_hsa000510.78521059
81Vibrio cholerae infection_Homo sapiens_hsa051100.78035488
82Adherens junction_Homo sapiens_hsa045200.76431719
83Proteoglycans in cancer_Homo sapiens_hsa052050.75455532
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72308813
85Wnt signaling pathway_Homo sapiens_hsa043100.71749631
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71571598
87Gap junction_Homo sapiens_hsa045400.70811248
88Collecting duct acid secretion_Homo sapiens_hsa049660.70769154
89Hepatitis B_Homo sapiens_hsa051610.70472456
90Arginine and proline metabolism_Homo sapiens_hsa003300.69992681
91Purine metabolism_Homo sapiens_hsa002300.69256162
92Melanogenesis_Homo sapiens_hsa049160.69091598
93Colorectal cancer_Homo sapiens_hsa052100.68268203
94MicroRNAs in cancer_Homo sapiens_hsa052060.66357228
95Alcoholism_Homo sapiens_hsa050340.65441644
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64907122
97Galactose metabolism_Homo sapiens_hsa000520.63992170
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.63272179
99Herpes simplex infection_Homo sapiens_hsa051680.62201942
100Regulation of autophagy_Homo sapiens_hsa041400.61143190
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60171976
102Epstein-Barr virus infection_Homo sapiens_hsa051690.59122321
103RNA degradation_Homo sapiens_hsa030180.58761674
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58354384
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58176211
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57798475
107Toxoplasmosis_Homo sapiens_hsa051450.57254565
108Prion diseases_Homo sapiens_hsa050200.57216939
109Influenza A_Homo sapiens_hsa051640.56844349
110HTLV-I infection_Homo sapiens_hsa051660.56145545
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.56101469
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55474789
113Fatty acid elongation_Homo sapiens_hsa000620.54505002
114Pentose phosphate pathway_Homo sapiens_hsa000300.53740946
115B cell receptor signaling pathway_Homo sapiens_hsa046620.53372665
116Selenocompound metabolism_Homo sapiens_hsa004500.51804680
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50528494
118ECM-receptor interaction_Homo sapiens_hsa045120.50092761
119Malaria_Homo sapiens_hsa051440.50079690
120Focal adhesion_Homo sapiens_hsa045100.50075681
121Measles_Homo sapiens_hsa051620.49334489
122Metabolic pathways_Homo sapiens_hsa011000.49286443
123Pathways in cancer_Homo sapiens_hsa052000.49060772
124Protein export_Homo sapiens_hsa030600.48614476
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48272591
126Small cell lung cancer_Homo sapiens_hsa052220.48236965
127Systemic lupus erythematosus_Homo sapiens_hsa053220.47398945
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47351890
129Viral carcinogenesis_Homo sapiens_hsa052030.45796064
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.45538945
131Shigellosis_Homo sapiens_hsa051310.42648492
132Pyruvate metabolism_Homo sapiens_hsa006200.42534050
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42287320
134TNF signaling pathway_Homo sapiens_hsa046680.41988541
135Chemokine signaling pathway_Homo sapiens_hsa040620.41913611
136mTOR signaling pathway_Homo sapiens_hsa041500.41157498
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40886617
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.39641046
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.39159133
140Melanoma_Homo sapiens_hsa052180.39053771
141Viral myocarditis_Homo sapiens_hsa054160.38102880
142Phenylalanine metabolism_Homo sapiens_hsa003600.36092320
143Protein digestion and absorption_Homo sapiens_hsa049740.35685271
144HIF-1 signaling pathway_Homo sapiens_hsa040660.35589446
145AMPK signaling pathway_Homo sapiens_hsa041520.35166980
146Fanconi anemia pathway_Homo sapiens_hsa034600.35150987
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35050670
148Endometrial cancer_Homo sapiens_hsa052130.33930708
149Dilated cardiomyopathy_Homo sapiens_hsa054140.32474218
150VEGF signaling pathway_Homo sapiens_hsa043700.32044118
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32040915

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