TSC22D4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment (GO:0008366)7.17409242
2ensheathment of neurons (GO:0007272)7.17409242
3myelination (GO:0042552)7.07185583
4creatine metabolic process (GO:0006600)6.22478514
5fatty acid elongation (GO:0030497)5.76166301
6myelin maintenance (GO:0043217)5.26186113
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05694833
8negative regulation of cell killing (GO:0031342)5.05694833
9oligodendrocyte differentiation (GO:0048709)5.03822113
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76055827
11long-chain fatty acid biosynthetic process (GO:0042759)4.62768401
12positive regulation of gamma-delta T cell activation (GO:0046645)4.62368370
13antigen processing and presentation of endogenous antigen (GO:0019883)4.59126794
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.56341460
15virion attachment to host cell (GO:0019062)4.54006001
16adhesion of symbiont to host cell (GO:0044650)4.54006001
17negative regulation of erythrocyte differentiation (GO:0045647)4.50870108
18negative regulation of protein localization to cell surface (GO:2000009)4.49987360
19astrocyte development (GO:0014002)4.48835682
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39539939
21peripheral nervous system axon ensheathment (GO:0032292)4.31022535
22myelination in peripheral nervous system (GO:0022011)4.31022535
23L-amino acid import (GO:0043092)4.30398398
24activated T cell proliferation (GO:0050798)4.27790368
25negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.95900662
26positive regulation by symbiont of host defense response (GO:0052509)3.93423816
27modulation by symbiont of host defense response (GO:0052031)3.93423816
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93423816
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93423816
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.93423816
31modulation by symbiont of host immune response (GO:0052553)3.93423816
32substantia nigra development (GO:0021762)3.90648708
33signal complex assembly (GO:0007172)3.86556267
34peptidyl-tyrosine autophosphorylation (GO:0038083)3.82445718
35membrane tubulation (GO:0097320)3.73577861
36regulation of collateral sprouting (GO:0048670)3.73469611
37detection of other organism (GO:0098543)3.72134098
38neutrophil activation involved in immune response (GO:0002283)3.70661379
39detection of bacterium (GO:0016045)3.70099718
40macrophage activation involved in immune response (GO:0002281)3.67753179
41positive thymic T cell selection (GO:0045059)3.67014781
42negative regulation of neurotransmitter secretion (GO:0046929)3.66997714
43eye photoreceptor cell differentiation (GO:0001754)3.64155976
44photoreceptor cell differentiation (GO:0046530)3.64155976
45regulation of B cell receptor signaling pathway (GO:0050855)3.57713517
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.56270475
47glycosylceramide metabolic process (GO:0006677)3.50176394
48amyloid precursor protein metabolic process (GO:0042982)3.49626450
49leukocyte migration involved in inflammatory response (GO:0002523)3.46128368
50response to peptidoglycan (GO:0032494)3.46099603
51cellular response to epinephrine stimulus (GO:0071872)3.41654051
52amino acid import (GO:0043090)3.39046307
53leukocyte aggregation (GO:0070486)3.38118007
54negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.37999946
55positive regulation of action potential (GO:0045760)3.36845068
56positive regulation of interleukin-17 production (GO:0032740)3.31982020
57positive regulation of oligodendrocyte differentiation (GO:0048714)3.31430799
58regulation of gamma-delta T cell activation (GO:0046643)3.30877157
59cholesterol biosynthetic process (GO:0006695)3.28418275
60adhesion of symbiont to host (GO:0044406)3.27496063
61asymmetric protein localization (GO:0008105)3.25485542
62response to redox state (GO:0051775)3.24147803
63response to muramyl dipeptide (GO:0032495)3.21309504
64thymic T cell selection (GO:0045061)3.20383746
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19638133
66regulation of mast cell degranulation (GO:0043304)3.17609796
67regulation of leukocyte degranulation (GO:0043300)3.16887668
68negative regulation of leukocyte mediated immunity (GO:0002704)3.15035474
69response to lipoprotein particle (GO:0055094)3.13261150
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.11571315
71import into cell (GO:0098657)3.10867699
72regulation of ARF protein signal transduction (GO:0032012)3.10539257
73response to epinephrine (GO:0071871)3.09825897
74negative regulation of neurotransmitter transport (GO:0051589)3.08732419
75regulation of gamma-delta T cell differentiation (GO:0045586)3.08427053
76protein palmitoylation (GO:0018345)3.06648483
77positive regulation of cellular amide metabolic process (GO:0034250)3.06282494
78detection of external biotic stimulus (GO:0098581)3.05796623
79positive regulation of Rap GTPase activity (GO:0032854)3.04607500
80membrane raft organization (GO:0031579)3.04298681
81amyloid precursor protein catabolic process (GO:0042987)3.02844553
82B cell receptor signaling pathway (GO:0050853)3.01875334
83response to methylmercury (GO:0051597)3.01460399
84cortical actin cytoskeleton organization (GO:0030866)2.96469444
85T cell selection (GO:0045058)2.93848051
86regulation of T-helper 2 cell differentiation (GO:0045628)2.93267302
87membrane protein ectodomain proteolysis (GO:0006509)2.92029996
88glial cell development (GO:0021782)2.91708816
89regulation of macrophage cytokine production (GO:0010935)2.91423948
90immunoglobulin mediated immune response (GO:0016064)2.89461523
91negative thymic T cell selection (GO:0045060)2.88750868
92positive regulation of macrophage cytokine production (GO:0060907)2.88740844
93response to interleukin-15 (GO:0070672)2.88373662
94germinal center formation (GO:0002467)2.87566657
95positive regulation of gliogenesis (GO:0014015)2.86656135
96regulation of regulated secretory pathway (GO:1903305)2.86485310
97cellular extravasation (GO:0045123)2.84431094
98positive regulation of glial cell differentiation (GO:0045687)2.84295225
99negative regulation of interleukin-12 production (GO:0032695)2.83647569
100neutrophil activation (GO:0042119)2.83160465
101regulation of actin filament-based movement (GO:1903115)2.82450591
102enteric nervous system development (GO:0048484)2.81988307
103positive T cell selection (GO:0043368)2.81429947
104sterol biosynthetic process (GO:0016126)2.81173503
105megakaryocyte development (GO:0035855)2.80604621
106positive regulation of interleukin-4 production (GO:0032753)2.80242606
107regulation of mast cell activation involved in immune response (GO:0033006)2.79118653
108cellular response to type I interferon (GO:0071357)2.77542626
109type I interferon signaling pathway (GO:0060337)2.77542626
110mannose metabolic process (GO:0006013)2.77035992
111response to type I interferon (GO:0034340)2.76502555
112regulation of cardiac muscle cell contraction (GO:0086004)2.76128849
113regulation of somitogenesis (GO:0014807)2.75576809
114cortical cytoskeleton organization (GO:0030865)2.74264176
115negative T cell selection (GO:0043383)2.71895373
116protein localization to endosome (GO:0036010)2.70117086
117negative regulation of axonogenesis (GO:0050771)2.69985535
118L-serine transport (GO:0015825)2.69947861
119granulocyte activation (GO:0036230)2.69854675
120positive regulation of B cell differentiation (GO:0045579)2.69801602
121negative regulation of inclusion body assembly (GO:0090084)2.69341563
122regulation of B cell differentiation (GO:0045577)2.68040822
123regulation of interferon-beta biosynthetic process (GO:0045357)2.66274805
124modulation by virus of host process (GO:0019054)2.66157335
125adenosine receptor signaling pathway (GO:0001973)2.65468917
126negative regulation of interleukin-10 production (GO:0032693)2.65013525
127GPI anchor biosynthetic process (GO:0006506)2.64208358
128axon development (GO:0061564)2.63942253
129modulation by symbiont of host cellular process (GO:0044068)2.63801286
130establishment of mitochondrion localization (GO:0051654)2.63523704
131myeloid cell activation involved in immune response (GO:0002275)2.63128513
132regulation of amyloid precursor protein catabolic process (GO:1902991)2.62494478
133detection of biotic stimulus (GO:0009595)2.62414125
134negative regulation of type 2 immune response (GO:0002829)2.61426922
135response to host immune response (GO:0052572)2.61223543
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61223543
137detection of molecule of bacterial origin (GO:0032490)2.61058664
138lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60998470
139negative regulation of T cell mediated immunity (GO:0002710)2.59641464
140glycerophospholipid catabolic process (GO:0046475)2.59389583
141cellular response to interleukin-15 (GO:0071350)2.58855697
142negative regulation of myoblast differentiation (GO:0045662)2.56920041
143macrophage activation (GO:0042116)2.56665850
144actin filament polymerization (GO:0030041)2.56386950
145isoprenoid biosynthetic process (GO:0008299)2.56138165
146apical protein localization (GO:0045176)2.56109533
147positive regulation of mast cell activation (GO:0033005)2.55025092
148glial cell differentiation (GO:0010001)2.54796431
149interferon-gamma-mediated signaling pathway (GO:0060333)2.54735396
150T cell migration (GO:0072678)2.54576458
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53772854
152regulation of interleukin-13 production (GO:0032656)2.53694678
153regulation of ARF GTPase activity (GO:0032312)2.51979300
154positive regulation of protein dephosphorylation (GO:0035307)2.51415963
155respiratory burst (GO:0045730)2.50678998
156long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.50351616
157regulation of T cell tolerance induction (GO:0002664)2.49370763
158magnesium ion transport (GO:0015693)2.48826738
159Rap protein signal transduction (GO:0032486)2.48604962
160regulation of Rap GTPase activity (GO:0032317)2.48546578
161positive regulation of mast cell activation involved in immune response (GO:0033008)2.46897546
162positive regulation of mast cell degranulation (GO:0043306)2.46897546
163regulation of natural killer cell mediated immunity (GO:0002715)2.46872810
164regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46872810
165response to host (GO:0075136)2.46231592
166response to host defenses (GO:0052200)2.46231592
167response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46231592
168regulation of defense response to virus by virus (GO:0050690)2.46104106
169ceramide biosynthetic process (GO:0046513)2.45660468
170sodium ion export (GO:0071436)2.45118277
171serine transport (GO:0032329)2.44788318
172regulation of relaxation of muscle (GO:1901077)2.42772481
173GPI anchor metabolic process (GO:0006505)2.42475913
174neural nucleus development (GO:0048857)2.42192739
175actin filament depolymerization (GO:0030042)2.41784836
176negative regulation of execution phase of apoptosis (GO:1900118)2.41668641
177cellular response to monoamine stimulus (GO:0071868)2.41060541
178cellular response to catecholamine stimulus (GO:0071870)2.41060541
179negative regulation of axon extension (GO:0030517)2.40909279
180presynaptic membrane organization (GO:0097090)2.40771977
181positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.39791650
182regulation of phospholipid biosynthetic process (GO:0071071)2.39417992
183negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.39112350
184negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.38016933
185regulation of interleukin-4 production (GO:0032673)2.37828334
186positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37178716
187positive regulation of protein targeting to membrane (GO:0090314)2.36617546
188organ growth (GO:0035265)2.35344544
189positive regulation of cell fate commitment (GO:0010455)2.34008995
190ear development (GO:0043583)2.32840607
191regulation of response to osmotic stress (GO:0047484)2.31819938
192negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.27186186
193response to monoamine (GO:0071867)2.27159710
194axon ensheathment in central nervous system (GO:0032291)10.7874230
195central nervous system myelination (GO:0022010)10.7874230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.36069126
2VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.60933923
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12527672
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.63212831
5MYC_22102868_ChIP-Seq_BL_Human2.51381472
6RUNX_20019798_ChIP-Seq_JUKART_Human2.51336874
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43099049
8SCL_19346495_ChIP-Seq_HPC-7_Human2.35973512
9VDR_21846776_ChIP-Seq_THP-1_Human2.34892690
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.30671810
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09710397
12VDR_24763502_ChIP-Seq_THP-1_Human1.96203858
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95870150
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.92535018
15NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.92294090
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92182204
17KDM2B_26808549_Chip-Seq_K562_Human1.83221324
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78400759
19DROSHA_22980978_ChIP-Seq_HELA_Human1.78069457
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73136029
21KDM2B_26808549_Chip-Seq_DND41_Human1.72905153
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68017296
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67344298
24TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66830180
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65960718
26GATA1_19941826_ChIP-Seq_K562_Human1.65613333
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65046354
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64176084
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62374494
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61276555
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.60671709
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59202252
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53320789
34CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53184806
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52585532
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51504896
37P68_20966046_ChIP-Seq_HELA_Human1.50925253
38SPI1_23127762_ChIP-Seq_K562_Human1.47869260
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47462479
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46488160
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44892015
42MAF_26560356_Chip-Seq_TH1_Human1.43359302
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42309164
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41933072
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41824451
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38812067
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38696079
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38493089
49SMC4_20622854_ChIP-Seq_HELA_Human1.37439947
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.37017986
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35592643
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34890398
53* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34239993
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33240915
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32411895
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32377466
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32193426
58* SPI1_23547873_ChIP-Seq_NB4_Human1.30519493
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.28960185
60LXR_22292898_ChIP-Seq_THP-1_Human1.28486188
61* BCL6_27268052_Chip-Seq_Bcells_Human1.27811812
62* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27467046
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27049892
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26774881
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26249051
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25712031
67CTCF_20526341_ChIP-Seq_ESCs_Human1.25177632
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24415945
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24342764
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24243600
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24126414
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.23754648
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23606143
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22541275
75VDR_24787735_ChIP-Seq_THP-1_Human1.21767101
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.21570018
77MAF_26560356_Chip-Seq_TH2_Human1.21550036
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21462932
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.21413798
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21363539
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19933577
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.19440581
83* TBX20_22080862_ChIP-Seq_HEART_Mouse1.18814699
84* TBX20_22328084_ChIP-Seq_HEART_Mouse1.18814699
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18141858
86* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18026808
87STAT1_20625510_ChIP-Seq_HELA_Human1.17826543
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.17477819
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17307398
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16009861
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15596419
92UTX_26944678_Chip-Seq_JUKART_Human1.15566271
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15298462
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.15271203
95AR_21572438_ChIP-Seq_LNCaP_Human1.15173393
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15009752
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14374478
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14374478
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12577962
100NCOR1_26117541_ChIP-Seq_K562_Human1.11811272
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.11686237
102MYB_26560356_Chip-Seq_TH2_Human1.10761809
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10055704
104MYB_26560356_Chip-Seq_TH1_Human1.09165672
105CREB1_26743006_Chip-Seq_LNCaP_Human1.08872274
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.07800898
107SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07636754
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.07624718
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06940329
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06287879
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.06262883
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.05920613
113SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05459728
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05143822
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05046473
116* BCOR_27268052_Chip-Seq_Bcells_Human1.05042645
117GATA2_19941826_ChIP-Seq_K562_Human1.04334548
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.04076185
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03471896
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03459018
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03379194
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02360649
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.01881322
124NANOG_20526341_ChIP-Seq_ESCs_Human1.01763546
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01750896
126SA1_27219007_Chip-Seq_Bcells_Human1.01442225
127IRF8_21731497_ChIP-ChIP_J774_Mouse1.01119284
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00134257
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99306789
130GATA3_27048872_Chip-Seq_THYMUS_Human0.98482912
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98455189
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98173344
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.97576065
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97389115
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97149547
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.96809208
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95544198
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95220824
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95114100
140TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92965903
141GATA1_26923725_Chip-Seq_HPCs_Mouse0.92152983
142CTCF_27219007_Chip-Seq_Bcells_Human0.91923271
143RACK7_27058665_Chip-Seq_MCF-7_Human0.91473396
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.89300146
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88781952
146RARB_27405468_Chip-Seq_BRAIN_Mouse0.88448843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.49964375
2MP0003436_decreased_susceptibility_to3.74904035
3MP0003690_abnormal_glial_cell3.50937788
4MP0003950_abnormal_plasma_membrane3.24516691
5MP0003724_increased_susceptibility_to2.89908783
6MP0001835_abnormal_antigen_presentation2.61388684
7MP0003136_yellow_coat_color2.61173852
8MP0003329_amyloid_beta_deposits2.58047707
9MP0005451_abnormal_body_composition2.39762980
10MP0003172_abnormal_lysosome_physiology2.39087462
11MP0004885_abnormal_endolymph2.36752947
12MP0004859_abnormal_synaptic_plasticity2.32012548
13MP0003634_abnormal_glial_cell2.31907424
14MP0003191_abnormal_cellular_cholesterol2.16778017
15MP0004381_abnormal_hair_follicle2.01030909
16MP0001485_abnormal_pinna_reflex1.91865728
17MP0004742_abnormal_vestibular_system1.91017906
18MP0005409_darkened_coat_color1.89981501
19MP0001533_abnormal_skeleton_physiology1.88026301
20MP0005464_abnormal_platelet_physiology1.87012293
21MP0001905_abnormal_dopamine_level1.85856987
22MP0005171_absent_coat_pigmentation1.84650463
23MP0005058_abnormal_lysosome_morphology1.79811327
24MP0005410_abnormal_fertilization1.79643419
25MP0000383_abnormal_hair_follicle1.76206505
26MP0004036_abnormal_muscle_relaxation1.72710559
27MP0000749_muscle_degeneration1.68339428
28MP0006082_CNS_inflammation1.65654965
29MP0003183_abnormal_peptide_metabolism1.65226466
30MP0004185_abnormal_adipocyte_glucose1.59865358
31MP0010155_abnormal_intestine_physiology1.57399707
32MP0005387_immune_system_phenotype1.56278808
33MP0001790_abnormal_immune_system1.56278808
34MP0000747_muscle_weakness1.56190158
35MP0000685_abnormal_immune_system1.55277310
36MP0000604_amyloidosis1.54619686
37MP0003705_abnormal_hypodermis_morpholog1.53910512
38MP0000751_myopathy1.53405504
39MP0005330_cardiomyopathy1.52168570
40MP0010678_abnormal_skin_adnexa1.52128555
41MP0001851_eye_inflammation1.50949174
42MP0000462_abnormal_digestive_system1.50924573
43MP0004142_abnormal_muscle_tone1.47342116
44MP0001529_abnormal_vocalization1.46004389
45MP0003763_abnormal_thymus_physiology1.45110800
46MP0005671_abnormal_response_to1.42081032
47MP0005166_decreased_susceptibility_to1.41706007
48MP0008569_lethality_at_weaning1.41219532
49MP0002933_joint_inflammation1.39981788
50MP0004084_abnormal_cardiac_muscle1.39781423
51MP0005000_abnormal_immune_tolerance1.39178774
52MP0003137_abnormal_impulse_conducting1.38084697
53MP0001486_abnormal_startle_reflex1.37710777
54MP0009840_abnormal_foam_cell1.37487538
55MP0005167_abnormal_blood-brain_barrier1.36160479
56MP0005397_hematopoietic_system_phenotyp1.35970650
57MP0001545_abnormal_hematopoietic_system1.35970650
58MP0002998_abnormal_bone_remodeling1.35362206
59MP0002272_abnormal_nervous_system1.35109983
60MP0003303_peritoneal_inflammation1.33340901
61MP0001845_abnormal_inflammatory_respons1.31202464
62MP0003880_abnormal_central_pattern1.28163676
63MP0000465_gastrointestinal_hemorrhage1.28126608
64MP0004134_abnormal_chest_morphology1.23692025
65MP0002429_abnormal_blood_cell1.21574876
66MP0002722_abnormal_immune_system1.21157027
67MP0002229_neurodegeneration1.18798430
68MP0000703_abnormal_thymus_morphology1.18345515
69MP0002837_dystrophic_cardiac_calcinosis1.18214467
70MP0003879_abnormal_hair_cell1.17402617
71MP0000858_altered_metastatic_potential1.17127898
72MP0002148_abnormal_hypersensitivity_rea1.17049051
73MP0004858_abnormal_nervous_system1.16862360
74MP0005025_abnormal_response_to1.16187198
75MP0003632_abnormal_nervous_system1.15881455
76MP0008874_decreased_physiological_sensi1.13408048
77MP0002420_abnormal_adaptive_immunity1.13133981
78MP0004270_analgesia1.13068853
79MP0002723_abnormal_immune_serum1.12713734
80MP0005623_abnormal_meninges_morphology1.12638705
81MP0005310_abnormal_salivary_gland1.11422029
82MP0002396_abnormal_hematopoietic_system1.11299085
83MP0004145_abnormal_muscle_electrophysio1.10491883
84MP0000689_abnormal_spleen_morphology1.10457306
85MP0003866_abnormal_defecation1.10142290
86MP0001819_abnormal_immune_cell1.09085907
87MP0001800_abnormal_humoral_immune1.09040405
88MP0001853_heart_inflammation1.08250834
89MP0002419_abnormal_innate_immunity1.07907326
90MP0003635_abnormal_synaptic_transmissio1.07732371
91MP0002064_seizures1.05949177
92MP0004510_myositis1.05793821
93MP0004087_abnormal_muscle_fiber1.04777756
94MP0004130_abnormal_muscle_cell1.04388373
95MP0009333_abnormal_splenocyte_physiolog1.01474916
96MP0009764_decreased_sensitivity_to1.01232470
97MP0008469_abnormal_protein_level1.00939505
98MP0002452_abnormal_antigen_presenting1.00766873
99MP0003075_altered_response_to0.97026170
100MP0002972_abnormal_cardiac_muscle0.96355557
101MP0000343_altered_response_to0.96143999
102MP0001958_emphysema0.95747441
103MP0004147_increased_porphyrin_level0.94403510
104MP0004215_abnormal_myocardial_fiber0.92278194
105MP0002106_abnormal_muscle_physiology0.91885038
106MP0002405_respiratory_system_inflammati0.89946521
107MP0003091_abnormal_cell_migration0.89909026
108MP0000716_abnormal_immune_system0.89690173
109MP0003448_altered_tumor_morphology0.89406586
110MP0008260_abnormal_autophagy0.87991604
111MP0005390_skeleton_phenotype0.87289094
112MP0003631_nervous_system_phenotype0.87148585
113MP0009785_altered_susceptibility_to0.86229635
114MP0003045_fibrosis0.84730768
115MP0003453_abnormal_keratinocyte_physiol0.83468645
116MP0003828_pulmonary_edema0.83237526
117MP0003633_abnormal_nervous_system0.83004199
118MP0002132_abnormal_respiratory_system0.82464928
119MP0009278_abnormal_bone_marrow0.82030511
120MP0008775_abnormal_heart_ventricle0.78697982
121MP0002063_abnormal_learning/memory/cond0.78359981
122MP0005666_abnormal_adipose_tissue0.77684845
123MP0005423_abnormal_somatic_nervous0.76799947
124MP0010630_abnormal_cardiac_muscle0.76723659
125MP0001873_stomach_inflammation0.75931121
126MP0003656_abnormal_erythrocyte_physiolo0.75553701
127MP0000778_abnormal_nervous_system0.75111871
128MP0005375_adipose_tissue_phenotype0.74598693
129MP0005381_digestive/alimentary_phenotyp0.74580877
130MP0001849_ear_inflammation0.74545479
131MP0002398_abnormal_bone_marrow0.74063224
132MP0003300_gastrointestinal_ulcer0.73198772
133MP0009384_cardiac_valve_regurgitation0.73007193
134MP0000733_abnormal_muscle_development0.72393428
135MP0003279_aneurysm0.72179126
136MP0000249_abnormal_blood_vessel0.71329961
137MP0005076_abnormal_cell_differentiation0.70812690
138MP0004947_skin_inflammation0.70306220
139MP0005369_muscle_phenotype0.70297713
140MP0003938_abnormal_ear_development0.69855856
141MP0001348_abnormal_lacrimal_gland0.69559199
142MP0005165_increased_susceptibility_to0.69071819
143MP0008438_abnormal_cutaneous_collagen0.67890697
144MP0004883_abnormal_blood_vessel0.67606667
145MP0001963_abnormal_hearing_physiology0.67543638
146MP0000750_abnormal_muscle_regeneration0.67522045
147MP0001663_abnormal_digestive_system0.67203772
148MP0001986_abnormal_taste_sensitivity0.66957557
149MP0005535_abnormal_body_temperature0.65598740

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.36952347
2Peripheral hypomyelination (HP:0007182)4.92443847
3Eczematoid dermatitis (HP:0000976)4.82198982
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.77958405
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.77958405
6Sensory axonal neuropathy (HP:0003390)4.36582793
7Parakeratosis (HP:0001036)4.28032285
8Recurrent abscess formation (HP:0002722)3.93157633
9Myositis (HP:0100614)3.84668244
10Premature skin wrinkling (HP:0100678)3.84271811
11Recurrent bacterial skin infections (HP:0005406)3.79851798
12Muscle fiber splitting (HP:0003555)3.71043387
13Onion bulb formation (HP:0003383)3.65974070
14Cerebral inclusion bodies (HP:0100314)3.54131229
15Orchitis (HP:0100796)3.44459228
16Chronic otitis media (HP:0000389)3.41285535
17Cerebral hypomyelination (HP:0006808)3.31681249
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.20578932
19Increased IgE level (HP:0003212)3.13865620
20Obstructive sleep apnea (HP:0002870)3.12388873
21Meningitis (HP:0001287)3.10903233
22Recurrent gram-negative bacterial infections (HP:0005420)3.08625181
23Mediastinal lymphadenopathy (HP:0100721)3.07286620
24Diplopia (HP:0000651)3.05356046
25Abnormality of binocular vision (HP:0011514)3.05356046
26Hyporeflexia of lower limbs (HP:0002600)3.03048577
27Supranuclear gaze palsy (HP:0000605)3.01071365
28Optic neuritis (HP:0100653)2.99994008
29Retrobulbar optic neuritis (HP:0100654)2.99994008
30Abnormality of the corticospinal tract (HP:0002492)2.93335882
31Slow saccadic eye movements (HP:0000514)2.92929529
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91816417
33Gastrointestinal infarctions (HP:0005244)2.79419637
34Abnormal auditory evoked potentials (HP:0006958)2.78175597
35Recurrent fungal infections (HP:0002841)2.74467634
36Hypoplastic pelvis (HP:0008839)2.68912195
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.67148590
38Gastrointestinal stroma tumor (HP:0100723)2.62270939
39Leukodystrophy (HP:0002415)2.62161507
40Gingivitis (HP:0000230)2.58890773
41Alacrima (HP:0000522)2.58327984
42Hepatosplenomegaly (HP:0001433)2.55002611
43Segmental peripheral demyelination/remyelination (HP:0003481)2.54426126
44Muscle hypertrophy of the lower extremities (HP:0008968)2.53260251
45Ankle clonus (HP:0011448)2.53133716
46Gastrointestinal inflammation (HP:0004386)2.49398888
47Panhypogammaglobulinemia (HP:0003139)2.48216612
48Vasculitis (HP:0002633)2.47853028
49Amyloidosis (HP:0011034)2.47548017
50Increased cerebral lipofuscin (HP:0011813)2.46018206
51Spastic gait (HP:0002064)2.44045786
52Clumsiness (HP:0002312)2.41891345
53Morphological abnormality of the inner ear (HP:0011390)2.39940095
54Stridor (HP:0010307)2.39904954
55Prolonged bleeding time (HP:0003010)2.39862904
56Spastic paraparesis (HP:0002313)2.39478075
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.38106415
58Urticaria (HP:0001025)2.37213400
59Intention tremor (HP:0002080)2.35374141
60Neuronal loss in central nervous system (HP:0002529)2.35188629
61Encephalitis (HP:0002383)2.33781488
62Congenital ichthyosiform erythroderma (HP:0007431)2.33078411
63Dysmetria (HP:0001310)2.30735240
64Dysostosis multiplex (HP:0000943)2.27425735
65Axonal loss (HP:0003447)2.26809379
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.25996459
67Abnormality of glycolipid metabolism (HP:0010969)2.25996459
68Abnormality of liposaccharide metabolism (HP:0010968)2.25996459
69Megalencephaly (HP:0001355)2.25263418
70Anteriorly placed anus (HP:0001545)2.24442975
71Polygenic inheritance (HP:0010982)2.24442443
72Colitis (HP:0002583)2.24066848
73Hypoplasia of the iris (HP:0007676)2.23276865
74Ventricular tachycardia (HP:0004756)2.21558264
75Gowers sign (HP:0003391)2.21533627
76Foot dorsiflexor weakness (HP:0009027)2.21126856
77Chest pain (HP:0100749)2.20436887
78Cerebral hemorrhage (HP:0001342)2.20312714
79Papilledema (HP:0001085)2.20085738
80Pustule (HP:0200039)2.20031759
81Sudden death (HP:0001699)2.19315119
82Episodic fever (HP:0001954)2.19250902
83Hemiplegia (HP:0002301)2.19169856
84White forelock (HP:0002211)2.18920667
85Exercise-induced myalgia (HP:0003738)2.17831822
86Patchy hypopigmentation of hair (HP:0011365)2.17594933
87Stomatitis (HP:0010280)2.16530970
88EMG: myopathic abnormalities (HP:0003458)2.16426071
89Pulmonary infiltrates (HP:0002113)2.15835228
90Calf muscle hypertrophy (HP:0008981)2.15691721
91Recurrent cutaneous fungal infections (HP:0011370)2.15216198
92Chronic mucocutaneous candidiasis (HP:0002728)2.15216198
93Retinal dysplasia (HP:0007973)2.14785495
94Partial duplication of thumb phalanx (HP:0009944)2.13642374
95Hypochromic anemia (HP:0001931)2.12622236
96Petechiae (HP:0000967)2.11979431
97Epistaxis (HP:0000421)2.11718712
98Keratoconjunctivitis sicca (HP:0001097)2.10548082
99Systemic lupus erythematosus (HP:0002725)2.10287557
100Cellulitis (HP:0100658)2.10251211
101Absent septum pellucidum (HP:0001331)2.10159362
102Pulmonary embolism (HP:0002204)2.09193920
103Annular pancreas (HP:0001734)2.09139328
104Recurrent viral infections (HP:0004429)2.08827759
105Increased serum pyruvate (HP:0003542)2.08762379
106Abnormality of glycolysis (HP:0004366)2.08762379
107Abnormality of the foot musculature (HP:0001436)2.06748451
108Split foot (HP:0001839)2.06448551
109Asplenia (HP:0001746)2.05662263
110Small epiphyses (HP:0010585)2.04341809
111Osteomyelitis (HP:0002754)2.02243734
112T lymphocytopenia (HP:0005403)2.00821507
113Loss of speech (HP:0002371)2.00263068
114Agammaglobulinemia (HP:0004432)2.00035630
115Increased circulating renin level (HP:0000848)2.00000929
116Barrel-shaped chest (HP:0001552)1.99654811
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98069051
118Sepsis (HP:0100806)1.96848132
119Large for gestational age (HP:0001520)1.96096129
120Difficulty running (HP:0009046)1.94657985
121Elevated erythrocyte sedimentation rate (HP:0003565)1.94505557
122Akinesia (HP:0002304)1.93831971
123Abnormality of macrophages (HP:0004311)1.93733918
124Progressive neurologic deterioration (HP:0002344)1.93667966
125Paraparesis (HP:0002385)1.93551599
126Scapular winging (HP:0003691)1.91590429
127Inflammation of the large intestine (HP:0002037)1.91509368
128Decreased lacrimation (HP:0000633)1.90687691
129Hemoptysis (HP:0002105)1.90230032
130Hypochromic microcytic anemia (HP:0004840)1.90063277
131Recurrent skin infections (HP:0001581)1.87835548
132Polycythemia (HP:0001901)1.87634149
133Hypertensive crisis (HP:0100735)1.87487973
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.86784993
135Spontaneous hematomas (HP:0007420)1.86090093
136Anomalous pulmonary venous return (HP:0010772)1.85710424
137Humeroradial synostosis (HP:0003041)1.85695047
138Synostosis involving the elbow (HP:0003938)1.85695047
139Abnormality of the salivary glands (HP:0010286)1.85384457
140Emphysema (HP:0002097)1.84913981
141Gingival bleeding (HP:0000225)1.84533979
142Metabolic alkalosis (HP:0200114)1.84410731
143Purpura (HP:0000979)1.84365900
144Pulmonary artery stenosis (HP:0004415)1.84312451
145Visual hallucinations (HP:0002367)1.83820501
146Keratoconjunctivitis (HP:0001096)1.81968221
147Chronic obstructive pulmonary disease (HP:0006510)1.81449895
148Obstructive lung disease (HP:0006536)1.81449895
149Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81349513
150Aplasia involving bones of the extremities (HP:0009825)1.80698557
151Aplasia involving bones of the upper limbs (HP:0009823)1.80698557
152Aplasia of the phalanges of the hand (HP:0009802)1.80698557
153Hypergammaglobulinemia (HP:0010702)1.80611750
154CNS hypomyelination (HP:0003429)1.80593156
155Granulocytopenia (HP:0001913)1.80495524
156Abnormality of T cell number (HP:0011839)1.80255637
157Cerebral aneurysm (HP:0004944)1.80183387
158Interstitial pulmonary disease (HP:0006530)1.79925304
159Atrial fibrillation (HP:0005110)1.79390632
160Dilated cardiomyopathy (HP:0001644)1.79324599
161Abnormality of the heme biosynthetic pathway (HP:0010472)1.78853873
162Increased neuronal autofluorescent lipopigment (HP:0002074)1.78309842
163Hypoplastic left heart (HP:0004383)1.78147963
164Partial duplication of the phalanx of hand (HP:0009999)1.77873108
165Abnormality of the nasal mucosa (HP:0000433)1.77359749
166Restrictive lung disease (HP:0002091)1.75981835
167Increased CSF protein (HP:0002922)1.75920328
168Erythroderma (HP:0001019)1.75608654
169Hyperacusis (HP:0010780)1.75417005
170Abnormality of the umbilical cord (HP:0010881)1.75237080
171Thickened helices (HP:0000391)1.74633488
172Acne (HP:0001061)1.74617930
173Arterial thrombosis (HP:0004420)1.74424664
174Ocular albinism (HP:0001107)1.72292280
175Metaphyseal cupping (HP:0003021)1.71970052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.35484528
2EPHB14.36744603
3RIPK43.58952324
4OXSR13.44539006
5ERN13.14731318
6RIPK12.76944912
7PKN12.43896152
8CDK192.41578997
9TNIK2.36305504
10MAP4K12.34751714
11CLK12.23810991
12ICK2.15548506
13MAP2K31.97777489
14MAPKAPK51.95179839
15WNK41.94094021
16TESK21.93870245
17MST41.84730483
18TYK21.83607072
19MAP3K111.83237674
20LIMK11.78014109
21ROCK21.74255593
22WNK11.62346603
23SMG11.58284980
24KSR21.55744834
25UHMK11.55119795
26MET1.53477898
27LMTK21.46299222
28FGFR21.45538681
29FES1.44639198
30SIK11.44362994
31DMPK1.43376453
32TAOK11.41728346
33PHKG21.41535160
34PHKG11.41535160
35TAOK21.41030470
36FGR1.35114816
37STK101.33715090
38CSNK1G31.31774507
39MAP3K11.30361631
40MAP3K31.26820861
41TRPM71.21944676
42TYRO31.21017052
43CSNK1A1L1.20501509
44CAMKK11.20491585
45PIK3CA1.18482936
46PRKD11.18332116
47SIK21.17841058
48PRKD31.17729709
49NEK61.17359517
50PRPF4B1.16879470
51CAMK2D1.15749236
52ITK1.15362920
53PRKCQ1.11584538
54JAK31.09209538
55TTN1.08321295
56IRAK21.07702515
57CSK1.07587133
58MARK21.06969346
59PBK1.02510166
60BCR1.02450152
61JAK11.02411833
62CSNK1G11.00958189
63IRAK41.00696514
64JAK20.99726342
65ARAF0.98551361
66IRAK30.97848900
67BLK0.97168662
68BTK0.95775838
69NLK0.94840483
70IRAK10.94812134
71NTRK30.94392455
72LCK0.91783688
73FGFR40.91503405
74PRKD20.90201982
75MAP3K140.88704872
76CAMK2B0.87517738
77CSF1R0.87289651
78DAPK20.87078249
79SIK30.86433366
80MUSK0.85790396
81PTK60.85491798
82LRRK20.82298831
83TXK0.80848792
84MAP2K20.80143890
85CDC42BPA0.78649449
86BMPR20.77274879
87EEF2K0.73007149
88CSNK1G20.72608079
89PDPK10.72168700
90FYN0.70780750
91HCK0.70595107
92PRKCH0.69738651
93IKBKE0.68580672
94TESK10.68180197
95RET0.67672155
96SGK30.67308013
97MAPK150.65667952
98PKN20.65441847
99STK40.64488085
100PDGFRB0.64287939
101GRK60.63457464
102STK380.63229858
103PRKG20.61556217
104PAK60.60482334
105ILK0.60357634
106MAP3K70.58192298
107CAMK2G0.58050770
108NTRK20.57057151
109MAPK70.56880703
110BMX0.54247682
111RPS6KL10.54046623
112RPS6KC10.54046623
113ROCK10.54046268
114RPS6KA20.53843133
115HIPK20.52638871
116PDK10.52129326
117MAPK40.52104042
118PAK30.51456915
119OBSCN0.51037553
120NTRK10.48007241
121DYRK1B0.47540419
122KIT0.46040921
123TRIB30.45439851
124SGK4940.44704247
125SGK2230.44704247
126ALK0.44332681
127LYN0.44237700
128CDK140.44135226
129TNK20.44047927
130STK110.43887206
131RPS6KA50.43710329
132FGFR30.43550828
133GRK70.43550654
134MAPK120.42344276
135BRAF0.42295889
136CDK120.41902828
137MAPK110.40826769
138TBK10.39125809
139RAF10.38919114
140CDK11A0.38672346
141CDK150.38312802
142RPS6KA60.37869069
143PAK10.37618885
144IKBKB0.36464274
145KDR0.35625022
146MAP3K130.34734880
147ZAP700.33699546
148DAPK30.33395110
149SYK0.33363402
150TLK10.33070664

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.28689491
2Fatty acid elongation_Homo sapiens_hsa000623.87837053
3Steroid biosynthesis_Homo sapiens_hsa001003.20874333
4Ether lipid metabolism_Homo sapiens_hsa005652.73736794
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66639264
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60585009
7Primary immunodeficiency_Homo sapiens_hsa053402.46196526
8Oxidative phosphorylation_Homo sapiens_hsa001902.07784503
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.99422459
10Sphingolipid metabolism_Homo sapiens_hsa006001.93984969
11Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72212449
12Parkinsons disease_Homo sapiens_hsa050121.72195503
13Staphylococcus aureus infection_Homo sapiens_hsa051501.64032851
14Cardiac muscle contraction_Homo sapiens_hsa042601.60602149
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60467071
16Alzheimers disease_Homo sapiens_hsa050101.60270470
17B cell receptor signaling pathway_Homo sapiens_hsa046621.60175971
18Renal cell carcinoma_Homo sapiens_hsa052111.56051760
19Graft-versus-host disease_Homo sapiens_hsa053321.54829923
20Axon guidance_Homo sapiens_hsa043601.53816762
21Tuberculosis_Homo sapiens_hsa051521.51175717
22T cell receptor signaling pathway_Homo sapiens_hsa046601.46514084
23Malaria_Homo sapiens_hsa051441.37665187
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37203568
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.37196132
26Non-small cell lung cancer_Homo sapiens_hsa052231.36833097
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29584551
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29472039
29Sphingolipid signaling pathway_Homo sapiens_hsa040711.26661360
30Long-term potentiation_Homo sapiens_hsa047201.25845491
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25115054
32Endocytosis_Homo sapiens_hsa041441.23648167
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23126725
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21033567
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19797945
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.17295793
37Linoleic acid metabolism_Homo sapiens_hsa005911.15022242
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13856286
39Prion diseases_Homo sapiens_hsa050201.11377867
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.09526756
41Synaptic vesicle cycle_Homo sapiens_hsa047211.06917405
42Other glycan degradation_Homo sapiens_hsa005111.06907992
43Pancreatic cancer_Homo sapiens_hsa052121.06357593
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06301951
45Influenza A_Homo sapiens_hsa051641.05130861
46GnRH signaling pathway_Homo sapiens_hsa049121.05058633
47Fatty acid biosynthesis_Homo sapiens_hsa000611.04499757
48Antigen processing and presentation_Homo sapiens_hsa046121.04469653
49Type I diabetes mellitus_Homo sapiens_hsa049401.04436784
50Hematopoietic cell lineage_Homo sapiens_hsa046401.03794707
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03526280
52Dilated cardiomyopathy_Homo sapiens_hsa054141.02769134
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01877454
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01357847
55Vitamin B6 metabolism_Homo sapiens_hsa007501.01094743
56Chemokine signaling pathway_Homo sapiens_hsa040621.00207177
57Lysosome_Homo sapiens_hsa041420.99423926
58TNF signaling pathway_Homo sapiens_hsa046680.98435847
59Glioma_Homo sapiens_hsa052140.97743028
60Viral myocarditis_Homo sapiens_hsa054160.97710574
61Hepatitis C_Homo sapiens_hsa051600.97363701
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97209620
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96099386
64Shigellosis_Homo sapiens_hsa051310.95886657
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94784179
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93843020
67Salmonella infection_Homo sapiens_hsa051320.93624978
68Tight junction_Homo sapiens_hsa045300.90931357
69mTOR signaling pathway_Homo sapiens_hsa041500.90862339
70Phagosome_Homo sapiens_hsa041450.90300152
71Estrogen signaling pathway_Homo sapiens_hsa049150.88405610
72Platelet activation_Homo sapiens_hsa046110.87956597
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87441082
74Endometrial cancer_Homo sapiens_hsa052130.87125260
75African trypanosomiasis_Homo sapiens_hsa051430.85789882
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85562607
77Fatty acid metabolism_Homo sapiens_hsa012120.85392686
78Arginine and proline metabolism_Homo sapiens_hsa003300.84941403
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84912935
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84615818
81Arachidonic acid metabolism_Homo sapiens_hsa005900.84593833
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83158127
83Autoimmune thyroid disease_Homo sapiens_hsa053200.82965858
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.82698922
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82368579
86Hepatitis B_Homo sapiens_hsa051610.81552665
87Osteoclast differentiation_Homo sapiens_hsa043800.81466236
88Sulfur metabolism_Homo sapiens_hsa009200.79622732
89Inositol phosphate metabolism_Homo sapiens_hsa005620.78974383
90Protein export_Homo sapiens_hsa030600.78792965
91Huntingtons disease_Homo sapiens_hsa050160.76424783
92Apoptosis_Homo sapiens_hsa042100.76384552
93Prolactin signaling pathway_Homo sapiens_hsa049170.75969254
94Herpes simplex infection_Homo sapiens_hsa051680.75130384
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.74885036
96Dorso-ventral axis formation_Homo sapiens_hsa043200.72697667
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71957680
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71896572
99Ras signaling pathway_Homo sapiens_hsa040140.70865389
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69367760
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.68726393
102Amoebiasis_Homo sapiens_hsa051460.66170467
103HIF-1 signaling pathway_Homo sapiens_hsa040660.65964847
104Rheumatoid arthritis_Homo sapiens_hsa053230.65457681
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65422684
106Cholinergic synapse_Homo sapiens_hsa047250.64145376
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64123236
108Notch signaling pathway_Homo sapiens_hsa043300.63792136
109Insulin signaling pathway_Homo sapiens_hsa049100.62205575
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.61652108
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.60480858
112Asthma_Homo sapiens_hsa053100.60435959
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60385753
114VEGF signaling pathway_Homo sapiens_hsa043700.59927846
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59822412
116Leishmaniasis_Homo sapiens_hsa051400.58898580
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58759582
118Morphine addiction_Homo sapiens_hsa050320.57774328
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57706614
120Choline metabolism in cancer_Homo sapiens_hsa052310.57435926
121Glutamatergic synapse_Homo sapiens_hsa047240.57284569
122ECM-receptor interaction_Homo sapiens_hsa045120.57080672
123Legionellosis_Homo sapiens_hsa051340.56670798
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.56510121
125Circadian entrainment_Homo sapiens_hsa047130.56232741
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54875224
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.54142379
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53926562
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53131861
130Serotonergic synapse_Homo sapiens_hsa047260.52076992
131Pancreatic secretion_Homo sapiens_hsa049720.51955309
132Gastric acid secretion_Homo sapiens_hsa049710.51853481
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51504392
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48934112
135Long-term depression_Homo sapiens_hsa047300.45776368
136Salivary secretion_Homo sapiens_hsa049700.45629863
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45099321
138ErbB signaling pathway_Homo sapiens_hsa040120.44629409
139Measles_Homo sapiens_hsa051620.44465167
140Focal adhesion_Homo sapiens_hsa045100.44164235
141Glutathione metabolism_Homo sapiens_hsa004800.43863704
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43371663
143Sulfur relay system_Homo sapiens_hsa041220.41495309
144MAPK signaling pathway_Homo sapiens_hsa040100.39163039
145Allograft rejection_Homo sapiens_hsa053300.38371865
146Ribosome_Homo sapiens_hsa030100.37704763
147Mineral absorption_Homo sapiens_hsa049780.37504166
148Acute myeloid leukemia_Homo sapiens_hsa052210.37110293
149Nitrogen metabolism_Homo sapiens_hsa009100.35509025
150Toxoplasmosis_Homo sapiens_hsa051450.34682627
151Pertussis_Homo sapiens_hsa051330.34364495
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33993332
153Rap1 signaling pathway_Homo sapiens_hsa040150.31946199
154Chronic myeloid leukemia_Homo sapiens_hsa052200.31557835

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