TSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.63874873
2presynaptic membrane assembly (GO:0097105)4.57824168
3proline transport (GO:0015824)4.37673263
4presynaptic membrane organization (GO:0097090)4.11356783
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11293460
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.09661049
7response to dietary excess (GO:0002021)3.82141383
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76683714
9locomotory exploration behavior (GO:0035641)3.76364878
10maintenance of protein location in nucleus (GO:0051457)3.70267803
11vocalization behavior (GO:0071625)3.65566576
12neurotransmitter-gated ion channel clustering (GO:0072578)3.64148657
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.61303563
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53818136
15polyketide metabolic process (GO:0030638)3.47026054
16doxorubicin metabolic process (GO:0044598)3.47026054
17daunorubicin metabolic process (GO:0044597)3.47026054
18glutamate secretion (GO:0014047)3.45671200
19synaptic transmission, glutamatergic (GO:0035249)3.36133047
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35251181
21somite rostral/caudal axis specification (GO:0032525)3.35231808
22neuron cell-cell adhesion (GO:0007158)3.33404815
23fibroblast migration (GO:0010761)3.33005232
24layer formation in cerebral cortex (GO:0021819)3.32855946
25positive regulation of glycolytic process (GO:0045821)3.27669960
26regulation of glutamate receptor signaling pathway (GO:1900449)3.27154915
27stress granule assembly (GO:0034063)3.26445978
28pyrimidine nucleobase catabolic process (GO:0006208)3.24222901
29dendritic spine morphogenesis (GO:0060997)3.19035921
30histone H4-K8 acetylation (GO:0043982)3.18698030
31histone H4-K5 acetylation (GO:0043981)3.18698030
32protein localization to synapse (GO:0035418)3.17160368
33glutamate receptor signaling pathway (GO:0007215)3.12829284
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12079355
35synaptic vesicle exocytosis (GO:0016079)3.10021715
36gamma-aminobutyric acid transport (GO:0015812)3.08562839
37regulation of response to osmotic stress (GO:0047484)3.07726480
38neuronal action potential propagation (GO:0019227)3.07420222
39protein K11-linked deubiquitination (GO:0035871)3.06215941
40negative regulation of potassium ion transmembrane transport (GO:1901380)3.03576719
41cell migration in hindbrain (GO:0021535)3.03218461
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02752060
43neuron-neuron synaptic transmission (GO:0007270)3.02547141
44neuron recognition (GO:0008038)3.01176618
45mitochondrion distribution (GO:0048311)2.99342940
46regulation of synaptic vesicle exocytosis (GO:2000300)2.99261001
47neurotransmitter secretion (GO:0007269)2.98835037
48inositol phosphate catabolic process (GO:0071545)2.98558431
49postsynaptic membrane organization (GO:0001941)2.98112111
50startle response (GO:0001964)2.96811177
51cerebellar Purkinje cell differentiation (GO:0021702)2.95573372
52central nervous system neuron axonogenesis (GO:0021955)2.94884985
53nerve growth factor signaling pathway (GO:0038180)2.93358009
54negative regulation of dendrite development (GO:2000171)2.92789636
55striatum development (GO:0021756)2.91046788
56negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89825767
57nucleobase catabolic process (GO:0046113)2.88241175
58axonal fasciculation (GO:0007413)2.87151444
59synaptic vesicle endocytosis (GO:0048488)2.85433828
60histone H4-K16 acetylation (GO:0043984)2.85120908
61transmission of nerve impulse (GO:0019226)2.84168866
62auditory behavior (GO:0031223)2.84072136
63cerebellar granule cell differentiation (GO:0021707)2.83216331
64dendrite morphogenesis (GO:0048813)2.81188087
65prepulse inhibition (GO:0060134)2.81181323
66central nervous system projection neuron axonogenesis (GO:0021952)2.80936998
67exploration behavior (GO:0035640)2.79954932
68regulation of neuronal synaptic plasticity (GO:0048168)2.79896323
69protein targeting to Golgi (GO:0000042)2.79888401
70regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79517988
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78997329
72pre-miRNA processing (GO:0031054)2.78556719
73coenzyme catabolic process (GO:0009109)2.77831391
74L-amino acid import (GO:0043092)2.76154284
75behavioral defense response (GO:0002209)2.75710456
76behavioral fear response (GO:0001662)2.75710456
77regulation of respiratory system process (GO:0044065)2.74548666
78nucleus localization (GO:0051647)2.74370482
79regulation of hexokinase activity (GO:1903299)2.74369656
80regulation of glucokinase activity (GO:0033131)2.74369656
81positive regulation of synapse maturation (GO:0090129)2.69754716
82phenol-containing compound catabolic process (GO:0019336)2.69656573
83neurotransmitter transport (GO:0006836)2.69325878
84sodium ion export (GO:0071436)2.67182258
85cellular potassium ion homeostasis (GO:0030007)2.66957395
86gamma-aminobutyric acid signaling pathway (GO:0007214)2.66257666
87calcium-mediated signaling using intracellular calcium source (GO:0035584)2.64778544
88regulation of dendritic spine development (GO:0060998)2.64362035
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63628227
90histone H3-K4 trimethylation (GO:0080182)2.62776145
91negative regulation of protein oligomerization (GO:0032460)2.60994652
92positive regulation of protein autophosphorylation (GO:0031954)2.59860294
93membrane depolarization during action potential (GO:0086010)2.59826876
94regulation of Rap GTPase activity (GO:0032317)2.59535525
95regulation of synapse structural plasticity (GO:0051823)2.59222668
96neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.59216824
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59189249
98long-term memory (GO:0007616)2.59087560
99establishment of protein localization to Golgi (GO:0072600)2.59029240
100neuromuscular process controlling balance (GO:0050885)2.58886194
101regulation of synaptic vesicle transport (GO:1902803)2.58647131
102brain morphogenesis (GO:0048854)2.58447262
103retinal cone cell development (GO:0046549)2.57644987
104regulation of dendritic spine morphogenesis (GO:0061001)2.55858165
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.55547780
106detection of temperature stimulus (GO:0016048)2.55456633
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55333057
108ovulation cycle (GO:0042698)2.55318037
109regulation of ARF protein signal transduction (GO:0032012)2.54875047
110histone H3-K4 methylation (GO:0051568)2.52421283
111phosphatidylinositol 3-kinase signaling (GO:0014065)2.52090001
112positive regulation of macroautophagy (GO:0016239)2.51482955
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50075807
114Golgi to endosome transport (GO:0006895)2.50008793
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49514699
116fear response (GO:0042596)2.49391377
117positive regulation of Rap GTPase activity (GO:0032854)2.48641536
118tachykinin receptor signaling pathway (GO:0007217)2.48194641
119establishment of nucleus localization (GO:0040023)2.47613889
120regulation of postsynaptic membrane potential (GO:0060078)2.46899745
121neuronal ion channel clustering (GO:0045161)2.46713929
122cell differentiation in hindbrain (GO:0021533)2.42790072
123activation of protein kinase A activity (GO:0034199)2.41785584
124positive regulation of membrane potential (GO:0045838)2.41422305
125detection of calcium ion (GO:0005513)2.41003594
126histone H4-K12 acetylation (GO:0043983)2.40882297
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.40763849
128negative regulation of dendrite morphogenesis (GO:0050774)2.40354626
129regulation of translation, ncRNA-mediated (GO:0045974)2.39402994
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39402994
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.39402994
132regulation of protein glycosylation (GO:0060049)2.37094492
133response to lipoprotein particle (GO:0055094)2.36212020
134positive regulation of neurotransmitter secretion (GO:0001956)2.36165775
135protein localization to Golgi apparatus (GO:0034067)2.36087177
136regulation of energy homeostasis (GO:2000505)2.35991874
137C4-dicarboxylate transport (GO:0015740)2.35977692
138adaptation of signaling pathway (GO:0023058)2.33803802
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.33196769
140polyol catabolic process (GO:0046174)2.32503652
141glycosphingolipid biosynthetic process (GO:0006688)2.31437644
142interkinetic nuclear migration (GO:0022027)2.29939171
143kidney morphogenesis (GO:0060993)2.28441471
144spinal cord motor neuron differentiation (GO:0021522)2.27358652
145acrosome reaction (GO:0007340)2.26888312
146regulation of respiratory gaseous exchange (GO:0043576)2.25916676
147regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.25115955
148positive regulation of neurotransmitter transport (GO:0051590)2.24421139
149olfactory bulb development (GO:0021772)2.23560827
150appendage development (GO:0048736)2.22691889
151limb development (GO:0060173)2.22691889
152alanine transport (GO:0032328)2.22631160
153righting reflex (GO:0060013)2.22191154
154phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.21312028
155regulation of acrosome reaction (GO:0060046)2.21170637
156glial cell proliferation (GO:0014009)2.20588634
157positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.20213430
158positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.20213430
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.20213430
160dendritic spine organization (GO:0097061)2.20152302
161regulation of Rac protein signal transduction (GO:0035020)2.19522848
162protein localization to cilium (GO:0061512)2.18846275
163regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.18818411
164regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.16481533
165intra-Golgi vesicle-mediated transport (GO:0006891)2.16177780
166prostate gland growth (GO:0060736)2.15086319
167inositol phosphate dephosphorylation (GO:0046855)2.15030230
168phosphorylated carbohydrate dephosphorylation (GO:0046838)2.15030230
169positive regulation of cardiac muscle cell differentiation (GO:2000727)2.13157029
170regulation of calcium ion-dependent exocytosis (GO:0017158)2.12446573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35617391
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.01038899
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.78564086
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76850843
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.76151742
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64899973
7GBX2_23144817_ChIP-Seq_PC3_Human2.55080257
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54280036
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54141040
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54141040
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54141040
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.43187106
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.42935561
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41370868
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40801503
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40731055
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40229323
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34439973
19ZNF274_21170338_ChIP-Seq_K562_Hela2.32185652
20REST_21632747_ChIP-Seq_MESCs_Mouse2.27095632
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22422890
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22322792
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22322792
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17632774
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10038971
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08767607
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08158182
28DROSHA_22980978_ChIP-Seq_HELA_Human1.96384078
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.92463854
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91760290
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.89491118
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.89419098
33TAF15_26573619_Chip-Seq_HEK293_Human1.89350604
34P300_19829295_ChIP-Seq_ESCs_Human1.88217404
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86499885
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82574902
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81404113
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78769149
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77856879
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76955156
41FUS_26573619_Chip-Seq_HEK293_Human1.70535505
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68966409
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.67879449
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65905089
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63662479
46VDR_22108803_ChIP-Seq_LS180_Human1.62513840
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61614974
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60749878
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60338063
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57202398
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.56278584
52KDM2B_26808549_Chip-Seq_K562_Human1.54146391
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.53992409
54AR_25329375_ChIP-Seq_VCAP_Human1.53949179
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53805122
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49358043
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49023966
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46963573
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45745709
60ER_23166858_ChIP-Seq_MCF-7_Human1.44905909
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.44378552
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.42209071
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.41476530
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40622514
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.40108084
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38898130
67CBP_20019798_ChIP-Seq_JUKART_Human1.38898130
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38225702
69BCAT_22108803_ChIP-Seq_LS180_Human1.37543800
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35792450
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35017175
72AR_19668381_ChIP-Seq_PC3_Human1.34552174
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.34207387
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32314209
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31221526
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30634539
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.30403582
78IGF1R_20145208_ChIP-Seq_DFB_Human1.29649191
79STAT3_23295773_ChIP-Seq_U87_Human1.29464005
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28747427
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27037935
82RUNX2_22187159_ChIP-Seq_PCA_Human1.27033146
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26976332
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.26533696
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26123921
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25972672
87AHR_22903824_ChIP-Seq_MCF-7_Human1.25689702
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.24963409
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24946928
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.24540042
91RNF2_27304074_Chip-Seq_NSC_Mouse1.24537673
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.23449339
93SMAD4_21799915_ChIP-Seq_A2780_Human1.23238731
94EWS_26573619_Chip-Seq_HEK293_Human1.23007787
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22980635
96TP53_16413492_ChIP-PET_HCT116_Human1.22828133
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21255656
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19064440
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.18611745
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18313902
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17773567
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17652472
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17609689
104KDM2B_26808549_Chip-Seq_REH_Human1.17391065
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16359747
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16008945
107TCF4_22108803_ChIP-Seq_LS180_Human1.16000190
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.15761093
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15169101
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.15145034
111KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13988380
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13385474
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12882625
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12719419
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11278121
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10661064
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10516108
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09866122
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09290055
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09290055
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.09165332
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08918752
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07973172
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.07965261
125P53_22387025_ChIP-Seq_ESCs_Mouse1.07614504
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07352445
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06692404
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05096506
129SMAD4_21741376_ChIP-Seq_HESCs_Human1.04358003
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04356307
131NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03866699
132DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03835988
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03834763
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03782228
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.03756450
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03629607
137YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02831889
138FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02236328
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02058726
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.01227645
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00316486
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.00200228
143SOX9_26525672_Chip-Seq_HEART_Mouse0.99818730
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99478070
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99374346
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99102836
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98325454
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.98018575
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97617062
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97328065
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97258432
152TCF4_23295773_ChIP-Seq_U87_Human0.94865088
153E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94398919
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.94374948
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.92238983
156POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91692996
157ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91597483
158TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91455779
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.90637150
160ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89397741
161AR_21572438_ChIP-Seq_LNCaP_Human0.89055872
162BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88023608
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87601525
164PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87578243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.50288068
2MP0003880_abnormal_central_pattern3.28380451
3MP0004270_analgesia3.16090732
4MP0002102_abnormal_ear_morphology3.10413283
5MP0003635_abnormal_synaptic_transmissio2.98358633
6MP0003122_maternal_imprinting2.75712744
7MP0009046_muscle_twitch2.68016050
8MP0004858_abnormal_nervous_system2.60600669
9MP0002064_seizures2.48567952
10MP0000569_abnormal_digit_pigmentation2.45812211
11MP0002063_abnormal_learning/memory/cond2.45631087
12MP0006292_abnormal_olfactory_placode2.39248419
13MP0002822_catalepsy2.38785676
14MP0001486_abnormal_startle_reflex2.38131227
15MP0009745_abnormal_behavioral_response2.32700877
16MP0008877_abnormal_DNA_methylation2.28359499
17MP0002572_abnormal_emotion/affect_behav2.27546917
18MP0005394_taste/olfaction_phenotype2.23791099
19MP0005499_abnormal_olfactory_system2.23791099
20MP0003787_abnormal_imprinting2.16540069
21MP0008961_abnormal_basal_metabolism2.11826688
22MP0002272_abnormal_nervous_system2.02111352
23MP0005423_abnormal_somatic_nervous2.00456838
24MP0003195_calcinosis1.98665928
25MP0003890_abnormal_embryonic-extraembry1.96400954
26MP0003283_abnormal_digestive_organ1.87395355
27MP0003121_genomic_imprinting1.86414852
28MP0003011_delayed_dark_adaptation1.86118324
29MP0000516_abnormal_urinary_system1.85044458
30MP0005367_renal/urinary_system_phenotyp1.85044458
31MP0002734_abnormal_mechanical_nocicepti1.78529441
32MP0002254_reproductive_system_inflammat1.75918836
33MP0000778_abnormal_nervous_system1.75492331
34MP0001440_abnormal_grooming_behavior1.74276303
35MP0001501_abnormal_sleep_pattern1.72376943
36MP0000427_abnormal_hair_cycle1.71237598
37MP0004264_abnormal_extraembryonic_tissu1.70941092
38MP0002909_abnormal_adrenal_gland1.67261532
39MP0004043_abnormal_pH_regulation1.62329840
40MP0000955_abnormal_spinal_cord1.62286540
41MP0002332_abnormal_exercise_endurance1.61953787
42MP0009780_abnormal_chondrocyte_physiolo1.59100919
43MP0004145_abnormal_muscle_electrophysio1.58707368
44MP0002733_abnormal_thermal_nociception1.55464959
45MP0000015_abnormal_ear_pigmentation1.49190046
46MP0002184_abnormal_innervation1.46655181
47MP0004885_abnormal_endolymph1.46292797
48MP0005174_abnormal_tail_pigmentation1.46007693
49MP0010678_abnormal_skin_adnexa1.45085472
50MP0003183_abnormal_peptide_metabolism1.42890830
51MP0002067_abnormal_sensory_capabilities1.42789819
52MP0000372_irregular_coat_pigmentation1.39807472
53MP0010234_abnormal_vibrissa_follicle1.36540666
54MP0001968_abnormal_touch/_nociception1.35771914
55MP0002928_abnormal_bile_duct1.35315160
56MP0005551_abnormal_eye_electrophysiolog1.34851664
57MP0001970_abnormal_pain_threshold1.34150413
58MP0003137_abnormal_impulse_conducting1.33463969
59MP0005646_abnormal_pituitary_gland1.32345393
60MP0000383_abnormal_hair_follicle1.30893049
61MP0002882_abnormal_neuron_morphology1.30497256
62MP0005386_behavior/neurological_phenoty1.26976255
63MP0004924_abnormal_behavior1.26976255
64MP0004142_abnormal_muscle_tone1.25594715
65MP0008057_abnormal_DNA_replication1.22294073
66MP0004811_abnormal_neuron_physiology1.21644315
67MP0000647_abnormal_sebaceous_gland1.21567387
68MP0004084_abnormal_cardiac_muscle1.20068492
69MP0002653_abnormal_ependyma_morphology1.19936665
70MP0002557_abnormal_social/conspecific_i1.19689088
71MP0002229_neurodegeneration1.15379638
72MP0002735_abnormal_chemical_nociception1.14269619
73MP0003690_abnormal_glial_cell1.14023726
74MP0010386_abnormal_urinary_bladder1.13873172
75MP0002066_abnormal_motor_capabilities/c1.13648099
76MP0003172_abnormal_lysosome_physiology1.13423787
77MP0004085_abnormal_heartbeat1.10252519
78MP0005187_abnormal_penis_morphology1.09423421
79MP0008569_lethality_at_weaning1.09067253
80MP0003938_abnormal_ear_development1.08685615
81MP0005409_darkened_coat_color1.08429525
82MP0005257_abnormal_intraocular_pressure1.07845713
83MP0003329_amyloid_beta_deposits1.07177315
84MP0005253_abnormal_eye_physiology1.06979471
85MP0005220_abnormal_exocrine_pancreas1.06818218
86MP0000371_diluted_coat_color1.06171583
87MP0002127_abnormal_cardiovascular_syste1.05762849
88MP0003646_muscle_fatigue1.03899443
89MP0000631_abnormal_neuroendocrine_gland1.03815822
90MP0003633_abnormal_nervous_system1.03486779
91MP0000538_abnormal_urinary_bladder1.02991800
92* MP0002152_abnormal_brain_morphology1.02749487
93MP0001984_abnormal_olfaction1.00559782
94MP0006276_abnormal_autonomic_nervous0.99117871
95MP0006072_abnormal_retinal_apoptosis0.98387650
96MP0006035_abnormal_mitochondrial_morpho0.97104349
97MP0003634_abnormal_glial_cell0.95920903
98MP0002751_abnormal_autonomic_nervous0.95423446
99MP0002752_abnormal_somatic_nervous0.95330092
100MP0004036_abnormal_muscle_relaxation0.95254829
101MP0002837_dystrophic_cardiac_calcinosis0.91312363
102MP0001177_atelectasis0.90716777
103MP0002876_abnormal_thyroid_physiology0.89884418
104MP0003632_abnormal_nervous_system0.88264434
105MP0001986_abnormal_taste_sensitivity0.87060337
106MP0001324_abnormal_eye_pigmentation0.86490833
107MP0003631_nervous_system_phenotype0.84364097
108MP0002095_abnormal_skin_pigmentation0.83356616
109MP0000920_abnormal_myelination0.83065853
110MP0000751_myopathy0.82936758
111* MP0003861_abnormal_nervous_system0.82799328
112MP0002168_other_aberrant_phenotype0.80835914
113MP0003868_abnormal_feces_composition0.80661884
114MP0002069_abnormal_eating/drinking_beha0.79355679
115MP0002938_white_spotting0.79021900
116MP0002638_abnormal_pupillary_reflex0.78284485
117MP0005075_abnormal_melanosome_morpholog0.77950836
118MP0004215_abnormal_myocardial_fiber0.77285214
119MP0000678_abnormal_parathyroid_gland0.76156076
120MP0002269_muscular_atrophy0.76109921
121MP0003045_fibrosis0.74734990
122MP0008872_abnormal_physiological_respon0.74379549
123MP0005379_endocrine/exocrine_gland_phen0.74082196
124MP0001944_abnormal_pancreas_morphology0.72750485
125MP0003123_paternal_imprinting0.71515773
126MP0003879_abnormal_hair_cell0.71228101
127MP0005248_abnormal_Harderian_gland0.71206157
128MP0005645_abnormal_hypothalamus_physiol0.70382004
129MP0002090_abnormal_vision0.69893051
130MP0002736_abnormal_nociception_after0.68662548
131MP0008770_decreased_survivor_rate0.67547474
132MP0008874_decreased_physiological_sensi0.66984794
133MP0000759_abnormal_skeletal_muscle0.66413187
134MP0001529_abnormal_vocalization0.64812326
135MP0001963_abnormal_hearing_physiology0.64458866
136MP0005391_vision/eye_phenotype0.63927926
137MP0005195_abnormal_posterior_eye0.63265614
138MP0003119_abnormal_digestive_system0.63092354

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.05081371
2Bilateral microphthalmos (HP:0007633)4.62100071
3Hypochromic microcytic anemia (HP:0004840)4.47157807
4Hepatoblastoma (HP:0002884)4.42204080
5Focal motor seizures (HP:0011153)4.07859043
6Epileptic encephalopathy (HP:0200134)3.83982102
7Hyperventilation (HP:0002883)3.83463334
8Febrile seizures (HP:0002373)3.59864501
9* Focal seizures (HP:0007359)3.49375664
10Neoplasm of the adrenal cortex (HP:0100641)3.45553790
11Abnormality of the corticospinal tract (HP:0002492)3.31022810
12Hyperinsulinemic hypoglycemia (HP:0000825)3.20968503
13Drooling (HP:0002307)3.12595102
14Excessive salivation (HP:0003781)3.12595102
15Fair hair (HP:0002286)3.06775286
16Supranuclear gaze palsy (HP:0000605)3.04992337
17Amyotrophic lateral sclerosis (HP:0007354)3.01045057
18Amblyopia (HP:0000646)2.98424159
19Myokymia (HP:0002411)2.97387584
20Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.96779565
21Difficulty running (HP:0009046)2.93932212
22Macroorchidism (HP:0000053)2.89375447
23Atonic seizures (HP:0010819)2.82876150
24Generalized tonic-clonic seizures (HP:0002069)2.79409478
25Generalized hypopigmentation of hair (HP:0011358)2.77682591
26Resting tremor (HP:0002322)2.74698855
27Hypoglycemic seizures (HP:0002173)2.74585223
28Visual hallucinations (HP:0002367)2.72572379
29Ketoacidosis (HP:0001993)2.69577520
30Tubulointerstitial nephritis (HP:0001970)2.63612922
31Generalized hypotonia (HP:0001290)2.61623159
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57011874
33Status epilepticus (HP:0002133)2.56371359
34Horizontal nystagmus (HP:0000666)2.55372450
35Asymmetry of the thorax (HP:0001555)2.53053838
36* Hemiparesis (HP:0001269)2.51882218
37Calf muscle hypertrophy (HP:0008981)2.51115564
38Absence seizures (HP:0002121)2.49146110
39Absent speech (HP:0001344)2.43626920
40Spastic tetraparesis (HP:0001285)2.40696395
41Dysdiadochokinesis (HP:0002075)2.38435627
42Abnormality of the pancreatic islet cells (HP:0006476)2.38243847
43Abnormality of endocrine pancreas physiology (HP:0012093)2.38243847
44Tetraplegia (HP:0002445)2.37867632
45Pancreatic cysts (HP:0001737)2.36913616
46Spastic gait (HP:0002064)2.35852231
47Hematochezia (HP:0002573)2.33800759
48Abnormality of the renal cortex (HP:0011035)2.33274896
49Blue irides (HP:0000635)2.33101164
50Ankle clonus (HP:0011448)2.32247434
51Widely spaced teeth (HP:0000687)2.31845057
52Hyperglycemia (HP:0003074)2.31182986
53Cerebral inclusion bodies (HP:0100314)2.28477406
54Epileptiform EEG discharges (HP:0011182)2.26796693
55Broad-based gait (HP:0002136)2.26346301
56Papillary thyroid carcinoma (HP:0002895)2.26285172
57Open mouth (HP:0000194)2.25835392
58Neurofibrillary tangles (HP:0002185)2.24502427
59Hypoplasia of the fovea (HP:0007750)2.24093588
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.24093588
61* Dialeptic seizures (HP:0011146)2.23831672
62EEG with generalized epileptiform discharges (HP:0011198)2.23268477
63Action tremor (HP:0002345)2.23231644
64Chronic hepatic failure (HP:0100626)2.21572555
65Renal cortical cysts (HP:0000803)2.21201376
66Hypoplastic ischia (HP:0003175)2.19559888
67Abnormal social behavior (HP:0012433)2.19414394
68Impaired social interactions (HP:0000735)2.19414394
69Hypothermia (HP:0002045)2.19019009
70Sensory axonal neuropathy (HP:0003390)2.18423795
71Gait imbalance (HP:0002141)2.18279818
72Medial flaring of the eyebrow (HP:0010747)2.18073253
73Enlarged penis (HP:0000040)2.17087762
74Neuronal loss in central nervous system (HP:0002529)2.16981502
75Rib fusion (HP:0000902)2.16590643
76Muscle hypertrophy of the lower extremities (HP:0008968)2.15589937
77Abnormality of the ischium (HP:0003174)2.14594270
78Hypoglycemic coma (HP:0001325)2.13482318
79Testicular atrophy (HP:0000029)2.12635945
80Abnormality of the metopic suture (HP:0005556)2.12012599
81Pancreatic fibrosis (HP:0100732)2.11761584
82Cutaneous melanoma (HP:0012056)2.10521395
83Lower limb muscle weakness (HP:0007340)2.10218208
84Hypsarrhythmia (HP:0002521)2.09355738
85Heterotopia (HP:0002282)2.09221304
86Dysmetria (HP:0001310)2.08890819
87Urinary bladder sphincter dysfunction (HP:0002839)2.06555357
88Intestinal atresia (HP:0011100)2.06077105
89Distal upper limb amyotrophy (HP:0007149)2.05954682
90Upper limb amyotrophy (HP:0009129)2.05954682
91Proximal amyotrophy (HP:0007126)2.05882538
92Generalized myoclonic seizures (HP:0002123)2.05333968
93Intention tremor (HP:0002080)2.03870290
94Depression (HP:0000716)2.03526335
95EMG: neuropathic changes (HP:0003445)2.03478570
96Hand muscle atrophy (HP:0009130)2.01816846
97Genital tract atresia (HP:0001827)2.01509572
98Aqueductal stenosis (HP:0002410)2.00706191
99Thyroid carcinoma (HP:0002890)2.00312060
100Truncal ataxia (HP:0002078)2.00179489
101Nephronophthisis (HP:0000090)1.98820155
102Albinism (HP:0001022)1.98164924
103Abnormality of the salivary glands (HP:0010286)1.97921170
104Abnormality of the pubic bones (HP:0003172)1.96327585
105Impaired vibration sensation in the lower limbs (HP:0002166)1.95885947
106Progressive cerebellar ataxia (HP:0002073)1.95351100
107Pseudobulbar signs (HP:0002200)1.94890950
108Protruding tongue (HP:0010808)1.94879619
109Congenital primary aphakia (HP:0007707)1.94257005
110Tubular atrophy (HP:0000092)1.93508476
111Type II lissencephaly (HP:0007260)1.92645476
112Abnormality of the calf musculature (HP:0001430)1.91992894
113Postural instability (HP:0002172)1.90986175
114Poor eye contact (HP:0000817)1.90815209
115Increased circulating renin level (HP:0000848)1.88964597
116Tented upper lip vermilion (HP:0010804)1.88571707
117Hip dysplasia (HP:0001385)1.88285338
118Supernumerary nipples (HP:0002558)1.88144257
119Bifid tongue (HP:0010297)1.86829343
120Hemiplegia (HP:0002301)1.86472417
121Hypomagnesemia (HP:0002917)1.86149994
122Polydipsia (HP:0001959)1.85628440
123Abnormal drinking behavior (HP:0030082)1.85628440
124True hermaphroditism (HP:0010459)1.85302740
125Clumsiness (HP:0002312)1.85008453
126Abnormality of ocular smooth pursuit (HP:0000617)1.84948198
127Increased corneal curvature (HP:0100692)1.84902103
128Keratoconus (HP:0000563)1.84902103
129Vaginal atresia (HP:0000148)1.84582446
130Prominent metopic ridge (HP:0005487)1.84103506
131Gastroesophageal reflux (HP:0002020)1.83934358
132Downturned corners of mouth (HP:0002714)1.83437153
133Lower limb amyotrophy (HP:0007210)1.83404616
134Renal duplication (HP:0000075)1.83267274
135Onion bulb formation (HP:0003383)1.82388598
136Abnormal hair whorl (HP:0010721)1.81964041
137Abnormality of the musculature of the hand (HP:0001421)1.81912147
138Gaze-evoked nystagmus (HP:0000640)1.81364022
139Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81360609
140Molar tooth sign on MRI (HP:0002419)1.80530957
141Abnormality of midbrain morphology (HP:0002418)1.80530957
142Fibular hypoplasia (HP:0003038)1.80138208
143Nephroblastoma (Wilms tumor) (HP:0002667)1.79482824
144Nephrogenic diabetes insipidus (HP:0009806)1.79289042
145Abnormality of the renal medulla (HP:0100957)1.79106380
146Aplasia/Hypoplasia of the macula (HP:0008059)1.78599302
147Abnormality of the fovea (HP:0000493)1.77018107
148Shawl scrotum (HP:0000049)1.76555320
149Abnormality of salivation (HP:0100755)1.76343371
150Exotropia (HP:0000577)1.75884581
151Thyroiditis (HP:0100646)1.75428279
152Cerebellar dysplasia (HP:0007033)1.74834721
153Intestinal fistula (HP:0100819)1.74646157
154Volvulus (HP:0002580)1.74111952
155Failure to thrive in infancy (HP:0001531)1.73529677
156Bradykinesia (HP:0002067)1.73527463
157Cystic liver disease (HP:0006706)1.73085048
158Congenital stationary night blindness (HP:0007642)1.73028826
159Large earlobe (HP:0009748)1.72768614
160Impaired vibratory sensation (HP:0002495)1.72465217
161Clonus (HP:0002169)1.72392612
162Morphological abnormality of the pyramidal tract (HP:0002062)1.72282518
163Deeply set eye (HP:0000490)1.70848276
164Ketosis (HP:0001946)1.70657138
165Urethral obstruction (HP:0000796)1.69161973
166* Abnormality of the astrocytes (HP:0100707)1.68762636
167* Astrocytoma (HP:0009592)1.68762636
168Intellectual disability, severe (HP:0010864)1.68538544
169Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67657493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.32993802
2CDK124.96480740
3GRK53.46260716
4NTRK33.24322438
5MAP3K92.76896895
6EPHA42.55476033
7TYRO32.45192590
8MARK12.41257829
9MAP3K42.20438600
10PAK62.16381770
11GRK62.15228411
12NTRK12.11780439
13MARK22.00639009
14MAP2K42.00092453
15ERN11.98886063
16WNK11.98010836
17BMPR1B1.78156595
18PLK21.78013745
19NTRK21.69574340
20SIK21.68566360
21ICK1.68173119
22MAP4K21.67212167
23GRK11.56871949
24DAPK21.53159632
25MAPK71.52614592
26TRIM281.50717024
27CAMKK21.49685234
28GRK71.45929250
29MAP3K71.43730616
30ADRBK21.43542394
31FER1.37190313
32PINK11.33537345
33SGK21.31455952
34CAMK41.27449774
35TNIK1.25065727
36CSF1R1.23009491
37ERBB31.22120086
38CAMK1G1.22068909
39STK38L1.20769142
40OBSCN1.20365466
41KSR21.19109853
42INSRR1.14276088
43ACVR1B1.12356412
44PRKD31.10061060
45NLK1.08618390
46RIPK41.07908521
47NUAK11.06836436
48PTK2B1.05339231
49PHKG21.04019902
50PHKG11.04019902
51STK391.03269072
52CDK51.02921744
53LATS11.02458472
54STK381.01201279
55PAK31.00851032
56WNK31.00553604
57KSR10.99443400
58MAP3K130.91959351
59HIPK20.91692125
60MINK10.90338113
61PRKCE0.89621850
62UHMK10.87282524
63MOS0.86248443
64MAPK130.82616419
65MAP2K70.82353794
66PRKAA20.82136199
67MAPK120.82112302
68STK30.81005856
69MATK0.80522304
70DMPK0.80255138
71CSNK1G10.78350127
72TAOK10.77925941
73PKN10.76099560
74STK110.74786006
75ROCK10.74611546
76CAMK1D0.74267489
77PRKCG0.72404289
78ALK0.72226493
79PNCK0.71355325
80TGFBR20.69525084
81MAPK100.69313990
82WNK40.66002135
83ADRBK10.65900894
84DYRK1A0.64335452
85PDGFRA0.61119339
86CDC42BPA0.60893621
87AKT20.60586754
88RPS6KA30.60557808
89SGK10.59583556
90PRKCH0.59493473
91MAP3K100.58888518
92CSNK1D0.58045085
93PRKAA10.58028242
94MTOR0.57253443
95MKNK20.56642133
96FES0.56253720
97ERBB20.55986177
98TNK20.55578000
99AKT30.55240729
100BRD40.55179136
101CAMK10.55153910
102PRKCZ0.54521862
103CDK150.53592722
104SGK4940.53504888
105SGK2230.53504888
106FGFR20.50863940
107CASK0.50732287
108PIK3CA0.50353205
109PTK20.50265424
110RET0.49634475
111PRKG10.49067673
112CDK180.48976537
113CSNK1G20.48728091
114PRKD20.48399170
115TTK0.48104120
116CSNK1A1L0.47953361
117RIPK10.47810842
118CAMK2A0.47566348
119PLK30.47506388
120SGK30.47452997
121FGFR30.47234836
122ATM0.46950556
123PRPF4B0.45988791
124GSK3B0.45549469
125OXSR10.44423833
126CSNK1E0.44071779
127YES10.43328836
128EPHA30.43263436
129CDK11A0.42343212
130TIE10.41590660
131CAMKK10.41167523
132PDK10.40658554
133CAMK2B0.40656867
134NEK60.40503541
135FYN0.40382828
136PDGFRB0.40236394
137CDK30.40135740
138CDK140.39920577
139LATS20.39169772
140MAPK80.39026014
141PRKD10.38578359
142IRAK20.37351757
143CSNK1A10.35338360

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.04946977
2GABAergic synapse_Homo sapiens_hsa047272.49241651
3Glutamatergic synapse_Homo sapiens_hsa047242.33931468
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32422037
5Nitrogen metabolism_Homo sapiens_hsa009102.20660746
6Vitamin B6 metabolism_Homo sapiens_hsa007502.10782220
7Long-term potentiation_Homo sapiens_hsa047202.02695023
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02387544
9Morphine addiction_Homo sapiens_hsa050321.94414290
10Circadian entrainment_Homo sapiens_hsa047131.94109578
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91202714
12Synaptic vesicle cycle_Homo sapiens_hsa047211.82558882
13Insulin secretion_Homo sapiens_hsa049111.72572392
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70440669
15Regulation of autophagy_Homo sapiens_hsa041401.68493103
16Amphetamine addiction_Homo sapiens_hsa050311.67624305
17Taste transduction_Homo sapiens_hsa047421.63029312
18Salivary secretion_Homo sapiens_hsa049701.59507189
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58042852
20Olfactory transduction_Homo sapiens_hsa047401.52348044
21Type II diabetes mellitus_Homo sapiens_hsa049301.52021132
22Dopaminergic synapse_Homo sapiens_hsa047281.51883033
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50042439
24Calcium signaling pathway_Homo sapiens_hsa040201.42514510
25Oxytocin signaling pathway_Homo sapiens_hsa049211.42491856
26Renin secretion_Homo sapiens_hsa049241.42177588
27GnRH signaling pathway_Homo sapiens_hsa049121.40454114
28Serotonergic synapse_Homo sapiens_hsa047261.37699286
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37615594
30Cholinergic synapse_Homo sapiens_hsa047251.34777690
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32922873
32Dorso-ventral axis formation_Homo sapiens_hsa043201.29761517
33Long-term depression_Homo sapiens_hsa047301.28920230
34Cocaine addiction_Homo sapiens_hsa050301.26249751
35cAMP signaling pathway_Homo sapiens_hsa040241.24337653
36Gastric acid secretion_Homo sapiens_hsa049711.23584196
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23426898
38Propanoate metabolism_Homo sapiens_hsa006401.21441035
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20684632
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19923366
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19826889
42* Phospholipase D signaling pathway_Homo sapiens_hsa040721.15363613
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12314193
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10358883
45Axon guidance_Homo sapiens_hsa043601.10209861
46Non-homologous end-joining_Homo sapiens_hsa034501.08849001
47Inositol phosphate metabolism_Homo sapiens_hsa005621.06730752
48* mTOR signaling pathway_Homo sapiens_hsa041501.06721295
49ErbB signaling pathway_Homo sapiens_hsa040121.05629005
50Dilated cardiomyopathy_Homo sapiens_hsa054141.05202377
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04239783
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01703140
53Bile secretion_Homo sapiens_hsa049761.01187824
54Fructose and mannose metabolism_Homo sapiens_hsa000510.99556976
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97566107
56* Choline metabolism in cancer_Homo sapiens_hsa052310.96268711
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96093706
58Sphingolipid metabolism_Homo sapiens_hsa006000.95141614
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.93711747
60Gap junction_Homo sapiens_hsa045400.92056078
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91178024
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90545853
63Glioma_Homo sapiens_hsa052140.90021321
64Estrogen signaling pathway_Homo sapiens_hsa049150.89321534
65Selenocompound metabolism_Homo sapiens_hsa004500.86156927
66Lysine degradation_Homo sapiens_hsa003100.84987053
67Ether lipid metabolism_Homo sapiens_hsa005650.84324813
68Ovarian steroidogenesis_Homo sapiens_hsa049130.83949983
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79652516
70FoxO signaling pathway_Homo sapiens_hsa040680.79588242
71Cardiac muscle contraction_Homo sapiens_hsa042600.77108901
72Arginine biosynthesis_Homo sapiens_hsa002200.75989771
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75857531
74Oocyte meiosis_Homo sapiens_hsa041140.75419656
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73367596
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72245292
77MAPK signaling pathway_Homo sapiens_hsa040100.71379231
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70498603
79Melanogenesis_Homo sapiens_hsa049160.70471917
80Phototransduction_Homo sapiens_hsa047440.70073952
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.68237921
82Butanoate metabolism_Homo sapiens_hsa006500.67627721
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.67147316
84Renal cell carcinoma_Homo sapiens_hsa052110.65697056
85Rap1 signaling pathway_Homo sapiens_hsa040150.64993171
86Glucagon signaling pathway_Homo sapiens_hsa049220.64065307
87Protein export_Homo sapiens_hsa030600.62963895
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62359262
89Hedgehog signaling pathway_Homo sapiens_hsa043400.62238340
90VEGF signaling pathway_Homo sapiens_hsa043700.61934166
91* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61288986
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60650090
93Non-small cell lung cancer_Homo sapiens_hsa052230.59869634
94Pancreatic secretion_Homo sapiens_hsa049720.59675326
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59232194
96Insulin resistance_Homo sapiens_hsa049310.58632673
97Tryptophan metabolism_Homo sapiens_hsa003800.57653474
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56343618
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55813150
100Ras signaling pathway_Homo sapiens_hsa040140.55668188
101Hippo signaling pathway_Homo sapiens_hsa043900.55024826
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.53734761
103Tight junction_Homo sapiens_hsa045300.53346076
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53240844
105Fatty acid metabolism_Homo sapiens_hsa012120.52999742
106beta-Alanine metabolism_Homo sapiens_hsa004100.50431358
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49995274
108Melanoma_Homo sapiens_hsa052180.49717663
109* AMPK signaling pathway_Homo sapiens_hsa041520.49464656
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.48256559
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47694495
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.46341020
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46083739
114Wnt signaling pathway_Homo sapiens_hsa043100.45022703
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.43770501
116Thyroid hormone synthesis_Homo sapiens_hsa049180.43306591
117Collecting duct acid secretion_Homo sapiens_hsa049660.42431785
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42172563
119Circadian rhythm_Homo sapiens_hsa047100.41273225
120ABC transporters_Homo sapiens_hsa020100.41273220
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.40596934
122* Insulin signaling pathway_Homo sapiens_hsa049100.39595514
123Endometrial cancer_Homo sapiens_hsa052130.37959602
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37580864
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37494534

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