TRPV5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)7.50177905
2drug transmembrane transport (GO:0006855)6.68900644
3folic acid metabolic process (GO:0046655)6.50991220
4drug transport (GO:0015893)6.45230672
5modified amino acid transport (GO:0072337)6.11711887
6folic acid transport (GO:0015884)5.91140400
7aminoglycoside antibiotic metabolic process (GO:0030647)5.85812706
8detection of molecule of bacterial origin (GO:0032490)5.79108266
9phosphate ion transport (GO:0006817)5.59482260
10leukotriene biosynthetic process (GO:0019370)5.39402310
11fructose metabolic process (GO:0006000)5.31058022
12lysine metabolic process (GO:0006553)5.20764989
13lysine catabolic process (GO:0006554)5.20764989
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.19048408
15positive regulation by organism of defense response of other organism involved in symbiotic interact5.19048408
16modulation by symbiont of host immune response (GO:0052553)5.19048408
17positive regulation by symbiont of host defense response (GO:0052509)5.19048408
18modulation by symbiont of host defense response (GO:0052031)5.19048408
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.19048408
20interferon-gamma secretion (GO:0072643)5.15768320
21organic cation transport (GO:0015695)5.08358279
22phosphate ion transmembrane transport (GO:0035435)5.03079887
23cellular extravasation (GO:0045123)4.89357516
24negative regulation of cAMP-mediated signaling (GO:0043951)4.79478726
25neutrophil activation involved in immune response (GO:0002283)4.76712353
26cysteine metabolic process (GO:0006534)4.75780009
27leukotriene metabolic process (GO:0006691)4.74864827
28vitamin D metabolic process (GO:0042359)4.69173891
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67690922
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.67017984
31drug catabolic process (GO:0042737)4.58282594
32NADH metabolic process (GO:0006734)4.53858738
33quaternary ammonium group transport (GO:0015697)4.53715551
34regulation of B cell receptor signaling pathway (GO:0050855)4.52317787
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39323148
36negative regulation of cell killing (GO:0031342)4.39323148
37excretion (GO:0007588)4.38267222
38vitamin transport (GO:0051180)4.33939284
39serine family amino acid metabolic process (GO:0009069)4.33855610
40macrophage activation involved in immune response (GO:0002281)4.29791494
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.29273012
42serine family amino acid catabolic process (GO:0009071)4.27666807
43microglial cell activation (GO:0001774)4.23068531
44glyoxylate metabolic process (GO:0046487)4.16803321
45neutrophil activation (GO:0042119)4.13506085
46purine nucleobase biosynthetic process (GO:0009113)4.12594977
47serine family amino acid biosynthetic process (GO:0009070)4.12073048
48tricarboxylic acid metabolic process (GO:0072350)4.11652556
49regulation of interferon-beta biosynthetic process (GO:0045357)4.08240901
50detection of external biotic stimulus (GO:0098581)4.03116799
51oligosaccharide catabolic process (GO:0009313)3.98109776
52nonribosomal peptide biosynthetic process (GO:0019184)3.96853504
53toxin transport (GO:1901998)3.94621838
54exogenous drug catabolic process (GO:0042738)3.94615222
55renal absorption (GO:0070293)3.94447877
56pantothenate metabolic process (GO:0015939)3.88703717
57homocysteine metabolic process (GO:0050667)3.87077542
58response to peptidoglycan (GO:0032494)3.85626134
59neutrophil mediated immunity (GO:0002446)3.85354683
60positive regulation of gamma-delta T cell activation (GO:0046645)3.81608348
61myeloid leukocyte mediated immunity (GO:0002444)3.76531600
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.76342792
63response to mercury ion (GO:0046689)3.75499868
64cell wall macromolecule catabolic process (GO:0016998)3.74532779
65proteasome assembly (GO:0043248)3.74442229
66glutathione biosynthetic process (GO:0006750)3.72120841
67amino sugar catabolic process (GO:0046348)3.71530369
68granulocyte activation (GO:0036230)3.71112707
69positive regulation of mast cell activation (GO:0033005)3.66754865
70branched-chain amino acid metabolic process (GO:0009081)3.64914655
71leukocyte migration involved in inflammatory response (GO:0002523)3.63773408
72amino-acid betaine transport (GO:0015838)3.62669292
73carnitine transport (GO:0015879)3.62669292
74cell wall macromolecule metabolic process (GO:0044036)3.61940552
75negative regulation of T-helper cell differentiation (GO:0045623)3.61464130
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.61464130
77alditol metabolic process (GO:0019400)3.60972166
78ribosome assembly (GO:0042255)3.59128788
79amino-acid betaine metabolic process (GO:0006577)3.58049326
80nucleobase biosynthetic process (GO:0046112)3.56746464
81aspartate family amino acid catabolic process (GO:0009068)3.52505117
82response to host immune response (GO:0052572)3.52342174
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52342174
84macrophage activation (GO:0042116)3.50723336
85heme transport (GO:0015886)3.49843730
86locomotory exploration behavior (GO:0035641)3.49817324
87negative regulation of interleukin-12 production (GO:0032695)3.49401031
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.49046553
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.48343352
90glycine metabolic process (GO:0006544)3.47515664
91positive regulation of mast cell degranulation (GO:0043306)3.46860591
92positive regulation of mast cell activation involved in immune response (GO:0033008)3.46860591
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44291904
94folic acid-containing compound metabolic process (GO:0006760)3.42003761
95trivalent inorganic anion homeostasis (GO:0072506)3.41731365
96phosphate ion homeostasis (GO:0055062)3.41731365
97detection of biotic stimulus (GO:0009595)3.41597251
98regulation of mast cell activation (GO:0033003)3.41169237
99vitamin transmembrane transport (GO:0035461)3.40952804
100myeloid cell activation involved in immune response (GO:0002275)3.39018996
101regulation of mast cell degranulation (GO:0043304)3.36099147
102biotin metabolic process (GO:0006768)3.35408994
103positive regulation of cellular amide metabolic process (GO:0034250)3.34449870
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34190329
105positive regulation of toll-like receptor signaling pathway (GO:0034123)3.30133396
106sulfur compound transport (GO:0072348)3.28961933
107branched-chain amino acid catabolic process (GO:0009083)3.28859108
108proline metabolic process (GO:0006560)3.28787597
109detection of other organism (GO:0098543)3.28729612
110regulation of beta-amyloid formation (GO:1902003)3.27743614
111metanephric tubule development (GO:0072170)3.26471580
112metanephric nephron tubule development (GO:0072234)3.26471580
113tricarboxylic acid cycle (GO:0006099)3.26465180
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26128223
115CDP-diacylglycerol metabolic process (GO:0046341)3.25789999
116regulation of cellular amino acid metabolic process (GO:0006521)3.25422279
117regulation of mast cell activation involved in immune response (GO:0033006)3.25366275
118oxygen transport (GO:0015671)3.24540293
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22926788
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20675603
121intestinal epithelial cell development (GO:0060576)3.20653087
122regulation of axon regeneration (GO:0048679)3.20431396
123regulation of neuron projection regeneration (GO:0070570)3.20431396
124positive regulation of granulocyte differentiation (GO:0030854)3.19670333
125lung-associated mesenchyme development (GO:0060484)3.18541525
126response to interleukin-15 (GO:0070672)3.18403287
127sulfur amino acid biosynthetic process (GO:0000097)3.17695365
128nucleoside diphosphate biosynthetic process (GO:0009133)3.15956176
129sulfur amino acid metabolic process (GO:0000096)3.14743616
130cofactor transport (GO:0051181)3.13502827
131negative regulation of immunoglobulin mediated immune response (GO:0002890)3.12713787
132negative regulation of B cell mediated immunity (GO:0002713)3.12713787
133positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11488852
134regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.10392047
135regulation of mitochondrial translation (GO:0070129)3.10277851
136mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10259660
137regulation of gamma-delta T cell activation (GO:0046643)3.10222744
138labyrinthine layer development (GO:0060711)3.09915656
139germinal center formation (GO:0002467)3.09518972
140glycoside metabolic process (GO:0016137)3.08463316
141formation of translation preinitiation complex (GO:0001731)3.07487202
142regulation of gamma-delta T cell differentiation (GO:0045586)3.06901376
143positive regulation of vasculogenesis (GO:2001214)3.06794436
144valine metabolic process (GO:0006573)3.06393325
145iron ion import (GO:0097286)3.05008346
1462-oxoglutarate metabolic process (GO:0006103)3.04187472
147negative regulation of type 2 immune response (GO:0002829)3.03760753
148ADP metabolic process (GO:0046031)3.02866926
149regulation of amyloid precursor protein catabolic process (GO:1902991)3.01641664
150cellular response to interleukin-15 (GO:0071350)3.01541864
151antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99236099
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98906785
153response to host (GO:0075136)2.98906785
154response to host defenses (GO:0052200)2.98906785
155positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98229941
156calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.97675026
157short-chain fatty acid metabolic process (GO:0046459)2.97519400
158metanephric nephron epithelium development (GO:0072243)2.96990826
159establishment of protein localization to Golgi (GO:0072600)2.96799803
160regulation of integrin-mediated signaling pathway (GO:2001044)2.95515829
161leukocyte degranulation (GO:0043299)2.91699655
162protein targeting to Golgi (GO:0000042)2.91660946
163natural killer cell differentiation (GO:0001779)2.89514318
164carnitine metabolic process (GO:0009437)2.87599769
165gas transport (GO:0015669)2.87286810
166negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87017460
167negative regulation of ligase activity (GO:0051352)2.87017460
168leukocyte aggregation (GO:0070486)2.86547419
169peptide biosynthetic process (GO:0043043)2.85249623
170production of molecular mediator involved in inflammatory response (GO:0002532)2.84800972
171glutathione derivative metabolic process (GO:1901685)2.84485036
172glutathione derivative biosynthetic process (GO:1901687)2.84485036
173erythrocyte development (GO:0048821)2.83187773
174respiratory burst (GO:0045730)2.83135683
175negative regulation of leukocyte mediated immunity (GO:0002704)2.83019531
176regulation of histone H3-K27 methylation (GO:0061085)2.82518641
177water-soluble vitamin metabolic process (GO:0006767)2.80265572
178aspartate family amino acid metabolic process (GO:0009066)2.78868689
179positive regulation of ligase activity (GO:0051351)2.77708192
180regulation of T-helper 2 cell differentiation (GO:0045628)2.77555168
181pteridine-containing compound metabolic process (GO:0042558)2.77135010
182B cell receptor signaling pathway (GO:0050853)2.76562316
183fatty acid derivative biosynthetic process (GO:1901570)2.75746104
184icosanoid biosynthetic process (GO:0046456)2.75746104
185positive regulation of macrophage cytokine production (GO:0060907)2.75459400
186AMP metabolic process (GO:0046033)2.75112189
187antigen processing and presentation of endogenous antigen (GO:0019883)2.74685766
188dicarboxylic acid metabolic process (GO:0043648)2.74414997
189erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.74221579
190L-phenylalanine metabolic process (GO:0006558)2.74221579
191blastocyst development (GO:0001824)2.74111448
192regulation of macrophage cytokine production (GO:0010935)2.73475606
193retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73359482
194signal peptide processing (GO:0006465)2.73019034
195negative regulation of erythrocyte differentiation (GO:0045647)2.72804463
196serotonin metabolic process (GO:0042428)2.71770436
197regulation of myeloid leukocyte mediated immunity (GO:0002886)2.71418328
198peptide catabolic process (GO:0043171)2.71064144
199positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.68567853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.07711007
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86566477
3AR_21909140_ChIP-Seq_LNCAP_Human3.45207797
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33488102
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.28078999
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23301853
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.23075762
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22514400
9SCL_19346495_ChIP-Seq_HPC-7_Human3.16095820
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04906009
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.02832893
12GATA1_22025678_ChIP-Seq_K562_Human3.01255358
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01059574
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.95472516
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.95315234
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92930329
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83242586
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67655740
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61127176
20VDR_22108803_ChIP-Seq_LS180_Human2.59605727
21RUNX_20019798_ChIP-Seq_JUKART_Human2.58455059
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.52517905
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.47493777
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41907260
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.41316970
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40730746
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38065355
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.37467871
29SPI1_23127762_ChIP-Seq_K562_Human2.36635049
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28986123
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28339850
32STAT3_1855785_ChIP-Seq_MESCs_Mouse2.24064815
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23985263
34GATA1_19941826_ChIP-Seq_K562_Human2.22945104
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.22051611
36NANOG_18555785_ChIP-Seq_MESCs_Mouse2.20063491
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19191353
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18447231
39MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17375782
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14750725
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07265546
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02574641
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.00461875
44E2F7_22180533_ChIP-Seq_HELA_Human1.99920473
45DROSHA_22980978_ChIP-Seq_HELA_Human1.99308282
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94707844
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94196217
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93805125
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92161904
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91651440
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.88282514
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.86311375
53VDR_24787735_ChIP-Seq_THP-1_Human1.86072242
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.85206502
55MYB_26560356_Chip-Seq_TH2_Human1.84701780
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84161875
57ZNF263_19887448_ChIP-Seq_K562_Human1.82790953
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82480328
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80398028
60IGF1R_20145208_ChIP-Seq_DFB_Human1.77800428
61VDR_23849224_ChIP-Seq_CD4+_Human1.75603945
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.73940774
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71909635
64VDR_24763502_ChIP-Seq_THP-1_Human1.71151636
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68686879
66GATA2_19941826_ChIP-Seq_K562_Human1.67292196
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66726448
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66316442
69XRN2_22483619_ChIP-Seq_HELA_Human1.65907375
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63619517
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63468199
72GBX2_23144817_ChIP-Seq_PC3_Human1.62855767
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61749171
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.60064350
75AR_21572438_ChIP-Seq_LNCaP_Human1.59827144
76DCP1A_22483619_ChIP-Seq_HELA_Human1.58406018
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57819553
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56184574
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.55271753
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55250014
81SPI1_23547873_ChIP-Seq_NB4_Human1.54749738
82GABP_19822575_ChIP-Seq_HepG2_Human1.53924669
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53468003
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.52270354
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51321073
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51318258
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48941584
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47975554
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.47822439
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.47614675
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47164739
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.46298544
93KDM5A_27292631_Chip-Seq_BREAST_Human1.45475908
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43003177
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42201331
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.42005647
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41304837
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.39871336
99GATA3_26560356_Chip-Seq_TH2_Human1.39670193
100RUNX1_22412390_ChIP-Seq_EML_Mouse1.39420653
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38582451
102TAF15_26573619_Chip-Seq_HEK293_Human1.37480067
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36216792
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36206486
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.35995301
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35134284
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34410063
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34328385
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32608279
110SMRT_27268052_Chip-Seq_Bcells_Human1.31926209
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31679005
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31096535
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30561290
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30291525
115NANOG_18692474_ChIP-Seq_MEFs_Mouse1.29688038
116GATA3_26560356_Chip-Seq_TH1_Human1.28824066
117MYB_26560356_Chip-Seq_TH1_Human1.26447300
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25193921
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24980994
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.24860287
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.24825088
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24363638
123SOX17_20123909_ChIP-Seq_XEN_Mouse1.24325128
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23083707
125FOXP3_21729870_ChIP-Seq_TREG_Human1.21875957
126KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19516881
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18347495
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17860285
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16213610
130VDR_21846776_ChIP-Seq_THP-1_Human1.16061812
131ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14800591
132MAF_26560356_Chip-Seq_TH1_Human1.14201961
133THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13702966
134TTF2_22483619_ChIP-Seq_HELA_Human1.12426131
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12313119
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11332364
137TFEB_21752829_ChIP-Seq_HELA_Human1.10957468
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.10833603
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10389793
140GATA4_25053715_ChIP-Seq_YYC3_Human1.10053561
141EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07728757
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07547143
143LXR_22158963_ChIP-Seq_LIVER_Mouse1.07286439
144PU_27001747_Chip-Seq_BMDM_Mouse1.06955412
145ATF3_27146783_Chip-Seq_COLON_Human1.06735272
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05794680
147RXR_22108803_ChIP-Seq_LS180_Human1.05673672
148ELK1_22589737_ChIP-Seq_MCF10A_Human1.05582673
149HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05082822
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04535122
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03426821
152OCT1_27270436_Chip-Seq_PROSTATE_Human1.03421001
153RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03102841
154NANOG_21062744_ChIP-ChIP_HESCs_Human1.02961180
155ER_23166858_ChIP-Seq_MCF-7_Human1.02115231
156CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01649114
157GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01404700
158SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01053155
159MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99770739
160PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99316389
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98325023
162SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98155217
163GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97249807
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96769607
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95910980
166SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95286562
167SALL4_22934838_ChIP-ChIP_CD34+_Human0.94852371
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94843795
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94029228
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93544211
171SALL1_21062744_ChIP-ChIP_HESCs_Human0.93318558
172GATA6_25053715_ChIP-Seq_YYC3_Human0.92865532
173NOTCH1_21737748_ChIP-Seq_TLL_Human0.92574328
174POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92434092
175YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92136234
176PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91952918
177ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91157109
178SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89983863
179ARNT_22903824_ChIP-Seq_MCF-7_Human0.89916168
180UTX_26944678_Chip-Seq_JUKART_Human0.89611336
181POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88794336
182FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88660242
183RACK7_27058665_Chip-Seq_MCF-7_Human0.87881032
184NFE2_27457419_Chip-Seq_LIVER_Mouse0.87795977
185* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87194412
186FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86314510
187STAT3_23295773_ChIP-Seq_U87_Human0.86119671
188REST_21632747_ChIP-Seq_MESCs_Mouse0.85615565
189ZNF274_21170338_ChIP-Seq_K562_Hela0.85376636
190ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84783615
191BCAT_22108803_ChIP-Seq_LS180_Human0.84368673
192HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82906732
193CBP_20019798_ChIP-Seq_JUKART_Human0.82228523
194IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82228523
195TCF7_22412390_ChIP-Seq_EML_Mouse0.81630730
196BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.80915617
197GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80680949
198TP53_16413492_ChIP-PET_HCT116_Human0.79263900
199ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79081946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism5.21213100
2MP0003724_increased_susceptibility_to5.07933944
3MP0005360_urolithiasis4.68966564
4MP0003195_calcinosis4.45164068
5MP0004043_abnormal_pH_regulation4.44792944
6MP0005332_abnormal_amino_acid4.29826009
7* MP0004019_abnormal_vitamin_homeostasis4.28034662
8MP0003693_abnormal_embryo_hatching3.80651924
9MP0003878_abnormal_ear_physiology3.79784194
10MP0005377_hearing/vestibular/ear_phenot3.79784194
11MP0009840_abnormal_foam_cell3.42976396
12* MP0009643_abnormal_urine_homeostasis3.42194892
13MP0002138_abnormal_hepatobiliary_system3.37059750
14MP0003303_peritoneal_inflammation3.21979401
15* MP0001756_abnormal_urination3.11768576
16MP0002139_abnormal_hepatobiliary_system3.09425937
17MP0001986_abnormal_taste_sensitivity2.70812095
18MP0005636_abnormal_mineral_homeostasis2.70613815
19MP0004381_abnormal_hair_follicle2.66856652
20* MP0001765_abnormal_ion_homeostasis2.65489806
21* MP0002136_abnormal_kidney_physiology2.60153187
22MP0004957_abnormal_blastocyst_morpholog2.56131939
23MP0003111_abnormal_nucleus_morphology2.55416374
24MP0003656_abnormal_erythrocyte_physiolo2.47528147
25MP0003806_abnormal_nucleotide_metabolis2.39576552
26MP0003436_decreased_susceptibility_to2.38268688
27MP0002419_abnormal_innate_immunity2.25165340
28MP0005671_abnormal_response_to2.19049767
29MP0003186_abnormal_redox_activity2.15146905
30MP0005365_abnormal_bile_salt2.13154142
31MP0000685_abnormal_immune_system2.09108078
32MP0003718_maternal_effect2.06883593
33MP0001835_abnormal_antigen_presentation2.06712890
34MP0005058_abnormal_lysosome_morphology2.01375055
35MP0001800_abnormal_humoral_immune1.95681593
36MP0001958_emphysema1.83069169
37MP0008877_abnormal_DNA_methylation1.77915267
38MP0005025_abnormal_response_to1.77643474
39MP0004130_abnormal_muscle_cell1.77507459
40MP0002420_abnormal_adaptive_immunity1.76013620
41MP0008875_abnormal_xenobiotic_pharmacok1.75373712
42MP0001819_abnormal_immune_cell1.74930482
43MP0008260_abnormal_autophagy1.73563538
44MP0002723_abnormal_immune_serum1.73471731
45MP0002452_abnormal_antigen_presenting1.71987924
46MP0005000_abnormal_immune_tolerance1.70631120
47MP0005451_abnormal_body_composition1.66234543
48MP0003690_abnormal_glial_cell1.62673607
49MP0002132_abnormal_respiratory_system1.61822459
50MP0008057_abnormal_DNA_replication1.60817144
51MP0005395_other_phenotype1.60261125
52MP0003315_abnormal_perineum_morphology1.59393532
53MP0005085_abnormal_gallbladder_physiolo1.59237824
54MP0005387_immune_system_phenotype1.56312302
55MP0001790_abnormal_immune_system1.56312302
56MP0002009_preneoplasia1.55508768
57MP0002653_abnormal_ependyma_morphology1.54803804
58MP0005084_abnormal_gallbladder_morpholo1.54398659
59MP0000569_abnormal_digit_pigmentation1.51597540
60MP0009785_altered_susceptibility_to1.50574993
61MP0003172_abnormal_lysosome_physiology1.49017751
62MP0006036_abnormal_mitochondrial_physio1.48328135
63MP0005310_abnormal_salivary_gland1.45332966
64MP0009278_abnormal_bone_marrow1.44751294
65MP0006082_CNS_inflammation1.44214224
66MP0004742_abnormal_vestibular_system1.43764061
67MP0004885_abnormal_endolymph1.42476242
68MP0005167_abnormal_blood-brain_barrier1.42194042
69MP0005397_hematopoietic_system_phenotyp1.41194724
70MP0001545_abnormal_hematopoietic_system1.41194724
71MP0002722_abnormal_immune_system1.40554588
72MP0003646_muscle_fatigue1.38474920
73MP0002398_abnormal_bone_marrow1.38286180
74MP0002405_respiratory_system_inflammati1.37175892
75MP0000689_abnormal_spleen_morphology1.36298071
76MP0001501_abnormal_sleep_pattern1.36261353
77MP0003077_abnormal_cell_cycle1.35596065
78MP0002148_abnormal_hypersensitivity_rea1.34131556
79MP0009764_decreased_sensitivity_to1.33441266
80MP0001730_embryonic_growth_arrest1.32103529
81MP0002735_abnormal_chemical_nociception1.31487787
82MP0008932_abnormal_embryonic_tissue1.31482044
83MP0001661_extended_life_span1.30871990
84MP0002168_other_aberrant_phenotype1.28752477
85MP0004264_abnormal_extraembryonic_tissu1.28623099
86MP0003252_abnormal_bile_duct1.27811210
87* MP0000716_abnormal_immune_system1.27370590
88MP0003763_abnormal_thymus_physiology1.27019942
89MP0001727_abnormal_embryo_implantation1.26688257
90MP0005379_endocrine/exocrine_gland_phen1.26218673
91MP0002277_abnormal_respiratory_mucosa1.23021319
92MP0006035_abnormal_mitochondrial_morpho1.22248288
93MP0000703_abnormal_thymus_morphology1.19041983
94MP0005464_abnormal_platelet_physiology1.18926870
95MP0001764_abnormal_homeostasis1.18133720
96MP0001533_abnormal_skeleton_physiology1.18108325
97MP0005319_abnormal_enzyme/_coenzyme1.16426433
98MP0002796_impaired_skin_barrier1.15642808
99MP0005423_abnormal_somatic_nervous1.14249619
100MP0010234_abnormal_vibrissa_follicle1.14146288
101MP0000465_gastrointestinal_hemorrhage1.11110806
102MP0001845_abnormal_inflammatory_respons1.11093998
103MP0002163_abnormal_gland_morphology1.10440190
104MP0001440_abnormal_grooming_behavior1.10146377
105MP0009765_abnormal_xenobiotic_induced1.09422174
106MP0010352_gastrointestinal_tract_polyps1.09044669
107MP0005584_abnormal_enzyme/coenzyme_acti1.03023760
108MP0002064_seizures1.01133944
109MP0005083_abnormal_biliary_tract1.00959000
110MP0010094_abnormal_chromosome_stability1.00692024
111MP0002135_abnormal_kidney_morphology0.98407482
112MP0003221_abnormal_cardiomyocyte_apopto0.98231079
113MP0003567_abnormal_fetal_cardiomyocyte0.97163567
114* MP0002429_abnormal_blood_cell0.97136943
115MP0002166_altered_tumor_susceptibility0.93807766
116MP0002876_abnormal_thyroid_physiology0.93429311
117MP0002272_abnormal_nervous_system0.93303230
118MP0000920_abnormal_myelination0.93006317
119MP0001485_abnormal_pinna_reflex0.92912023
120MP0009046_muscle_twitch0.92827264
121MP0000358_abnormal_cell_content/0.92270852
122MP0002971_abnormal_brown_adipose0.91352397
123MP0003786_premature_aging0.89980271
124MP0001697_abnormal_embryo_size0.87471274
125MP0005380_embryogenesis_phenotype0.87103499
126MP0001672_abnormal_embryogenesis/_devel0.87103499
127MP0002909_abnormal_adrenal_gland0.86962784
128MP0003828_pulmonary_edema0.85600355
129MP0009745_abnormal_behavioral_response0.83491809
130MP0003075_altered_response_to0.83388010
131MP0003191_abnormal_cellular_cholesterol0.82460762
132MP0004510_myositis0.81636676
133MP0004883_abnormal_blood_vessel0.81121266
134MP0005501_abnormal_skin_physiology0.80154432
135MP0000747_muscle_weakness0.79929071
136MP0003984_embryonic_growth_retardation0.79898582
137MP0002088_abnormal_embryonic_growth/wei0.79744267
138MP0000371_diluted_coat_color0.79220845
139MP0008469_abnormal_protein_level0.78783828
140MP0003329_amyloid_beta_deposits0.77092908
141MP0003631_nervous_system_phenotype0.76673826
142MP0002080_prenatal_lethality0.76257341
143MP0004142_abnormal_muscle_tone0.75727854
144MP0004947_skin_inflammation0.75520485
145MP0000427_abnormal_hair_cycle0.74926346
146MP0002098_abnormal_vibrissa_morphology0.74353593
147MP0004147_increased_porphyrin_level0.74227187
148MP0005164_abnormal_response_to0.74195859
149MP0003959_abnormal_lean_body0.74027433
150MP0000609_abnormal_liver_physiology0.73827343
151MP0003045_fibrosis0.73693854
152MP0002229_neurodegeneration0.73600690
153MP0003632_abnormal_nervous_system0.73510763
154MP0001486_abnormal_startle_reflex0.73491501
155MP0003633_abnormal_nervous_system0.73449895
156MP0002118_abnormal_lipid_homeostasis0.73236574
157MP0001666_abnormal_nutrient_absorption0.73215974
158MP0005670_abnormal_white_adipose0.72954226
159MP0001542_abnormal_bone_strength0.71655354
160MP0005666_abnormal_adipose_tissue0.71192425
161MP0005075_abnormal_melanosome_morpholog0.71022434
162MP0002086_abnormal_extraembryonic_tissu0.69250048
163MP0000598_abnormal_liver_morphology0.68613787
164MP0005408_hypopigmentation0.68590798
165MP0009672_abnormal_birth_weight0.67197783
166MP0000377_abnormal_hair_follicle0.66869459
167MP0008058_abnormal_DNA_repair0.64663160
168MP0000537_abnormal_urethra_morphology0.60715420
169MP0010329_abnormal_lipoprotein_level0.58199391
170MP0009642_abnormal_blood_homeostasis0.57534970
171MP0003300_gastrointestinal_ulcer0.57007383
172MP0000230_abnormal_systemic_arterial0.56347047
173MP0003866_abnormal_defecation0.54266123
174MP0000538_abnormal_urinary_bladder0.52032403
175MP0005330_cardiomyopathy0.51815077
176MP0002085_abnormal_embryonic_tissue0.51229918
177MP0003938_abnormal_ear_development0.51102697
178MP0001216_abnormal_epidermal_layer0.50103689
179MP0000490_abnormal_crypts_of0.48848185
180MP0000477_abnormal_intestine_morphology0.48067700
181MP0003638_abnormal_response/metabolism_0.47790167
182MP0004484_altered_response_of0.47694984
183MP0003879_abnormal_hair_cell0.47655974
184MP0001145_abnormal_male_reproductive0.46547998
185MP0004084_abnormal_cardiac_muscle0.46507107
186MP0000350_abnormal_cell_proliferation0.46118133
187MP0002396_abnormal_hematopoietic_system0.45866040

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.86753833
2Increased circulating renin level (HP:0000848)6.55899897
3Hypokalemic alkalosis (HP:0001949)6.09948746
4Proximal tubulopathy (HP:0000114)5.76783495
5Hypomagnesemia (HP:0002917)5.67756009
6Metabolic alkalosis (HP:0200114)5.66127282
7Polyuria (HP:0000103)5.44586675
8Hyperactive renin-angiotensin system (HP:0000841)5.43841638
9Abnormal urine output (HP:0012590)5.01027970
10Abnormality of chloride homeostasis (HP:0011422)4.98800051
11Abnormality of magnesium homeostasis (HP:0004921)4.98282932
12Hyperglycinuria (HP:0003108)4.83568758
13Abnormality of renal excretion (HP:0011036)4.73943045
14Increased purine levels (HP:0004368)4.57828338
15Hyperuricemia (HP:0002149)4.57828338
16Abnormality of glycine metabolism (HP:0010895)4.13280314
17Abnormality of serine family amino acid metabolism (HP:0010894)4.13280314
18Tetany (HP:0001281)4.11585972
19Eczematoid dermatitis (HP:0000976)4.08198460
20Alkalosis (HP:0001948)4.07068292
21Recurrent bacterial skin infections (HP:0005406)4.03274002
22Renal salt wasting (HP:0000127)4.00834603
23Keratoconjunctivitis sicca (HP:0001097)3.95768591
24Recurrent abscess formation (HP:0002722)3.87603880
25Myositis (HP:0100614)3.82239116
26Glycosuria (HP:0003076)3.79764581
27Abnormality of urine glucose concentration (HP:0011016)3.79764581
28Generalized aminoaciduria (HP:0002909)3.79591595
29Abnormality of renin-angiotensin system (HP:0000847)3.79146949
30Abnormality of the heme biosynthetic pathway (HP:0010472)3.75429549
31Optic neuritis (HP:0100653)3.75289149
32Retrobulbar optic neuritis (HP:0100654)3.75289149
33Abnormal drinking behavior (HP:0030082)3.71098257
34Polydipsia (HP:0001959)3.71098257
35Orchitis (HP:0100796)3.69901098
36Abnormality of purine metabolism (HP:0004352)3.62419712
37Hyperaldosteronism (HP:0000859)3.62067512
38Increased cerebral lipofuscin (HP:0011813)3.56837194
39Hyperglycinemia (HP:0002154)3.56794865
40Keratoconjunctivitis (HP:0001096)3.55850864
41Abnormality of macrophages (HP:0004311)3.49775961
42Hypochromic microcytic anemia (HP:0004840)3.40751827
43Increased neuronal autofluorescent lipopigment (HP:0002074)3.39711784
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.39507881
45Spontaneous hematomas (HP:0007420)3.38105983
46Microcytic anemia (HP:0001935)3.27627366
47Encephalitis (HP:0002383)3.26675692
48Hypercalciuria (HP:0002150)3.17021202
49Recurrent fungal infections (HP:0002841)3.02430347
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.99908912
51Dicarboxylic aciduria (HP:0003215)2.99908912
52Toxemia of pregnancy (HP:0100603)2.94246020
53Abnormality of fatty-acid metabolism (HP:0004359)2.92752708
54Hyperphosphaturia (HP:0003109)2.92493945
55Slow saccadic eye movements (HP:0000514)2.90966787
56Abnormality of nucleobase metabolism (HP:0010932)2.90623680
57Carpal bone hypoplasia (HP:0001498)2.89419801
58Delayed epiphyseal ossification (HP:0002663)2.88410338
59Hypokalemia (HP:0002900)2.88387349
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88039832
61Megaloblastic anemia (HP:0001889)2.86449707
62Recurrent gram-negative bacterial infections (HP:0005420)2.85646435
63Genetic anticipation (HP:0003743)2.85387075
64Hypochromic anemia (HP:0001931)2.85193985
65Hyperammonemia (HP:0001987)2.83634281
66Stomatitis (HP:0010280)2.83602616
67Poikilocytosis (HP:0004447)2.79945956
68Nausea (HP:0002018)2.78018716
69Lethargy (HP:0001254)2.76319128
70Renal tubular acidosis (HP:0001947)2.75150774
71Obstructive lung disease (HP:0006536)2.70887328
72Chronic obstructive pulmonary disease (HP:0006510)2.70887328
73Abnormality of serum amino acid levels (HP:0003112)2.67616950
74Prolonged bleeding time (HP:0003010)2.66549303
75Prolonged neonatal jaundice (HP:0006579)2.65098452
76Gastrointestinal infarctions (HP:0005244)2.62004738
77Gingivitis (HP:0000230)2.57741098
78Abnormality of homocysteine metabolism (HP:0010919)2.55029955
79Homocystinuria (HP:0002156)2.55029955
80Nephrocalcinosis (HP:0000121)2.54088954
81Recurrent cutaneous fungal infections (HP:0011370)2.53936916
82Chronic mucocutaneous candidiasis (HP:0002728)2.53936916
83Meningitis (HP:0001287)2.53639739
84Recurrent skin infections (HP:0001581)2.52977907
85Vertebral arch anomaly (HP:0008438)2.52836953
86Methylmalonic aciduria (HP:0012120)2.52399547
87Pustule (HP:0200039)2.52235737
88Leukocytosis (HP:0001974)2.52168363
89Abnormal urine phosphate concentration (HP:0012599)2.51760519
90Granulocytopenia (HP:0001913)2.49672014
91Mediastinal lymphadenopathy (HP:0100721)2.48192657
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.47808703
93Papilledema (HP:0001085)2.47098637
94Chest pain (HP:0100749)2.43576583
95Vacuolated lymphocytes (HP:0001922)2.40876739
96Postural instability (HP:0002172)2.40701795
97Ketoacidosis (HP:0001993)2.36890118
98Abnormality of binocular vision (HP:0011514)2.36541409
99Diplopia (HP:0000651)2.36541409
100Vomiting (HP:0002013)2.34864034
101Confusion (HP:0001289)2.34505231
102Autoimmune thrombocytopenia (HP:0001973)2.32230687
103Nephrolithiasis (HP:0000787)2.31705981
104Metaphyseal cupping (HP:0003021)2.30941535
105Thickened calvaria (HP:0002684)2.29979592
106Disinhibition (HP:0000734)2.27675147
107Elevated erythrocyte sedimentation rate (HP:0003565)2.26453739
108Abnormality of the fingertips (HP:0001211)2.26122123
109Abnormality of potassium homeostasis (HP:0011042)2.25560699
110Delayed CNS myelination (HP:0002188)2.24831563
111Epistaxis (HP:0000421)2.23640601
112Vasculitis (HP:0002633)2.22885028
113Hyponatremia (HP:0002902)2.21227246
114Bilateral sensorineural hearing impairment (HP:0008619)2.20098738
115Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19951568
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19917642
117Nonprogressive disorder (HP:0003680)2.18663275
118Pulmonary embolism (HP:0002204)2.17628256
119Arterial thrombosis (HP:0004420)2.17524804
120Gingival bleeding (HP:0000225)2.17028122
121Ketosis (HP:0001946)2.16729337
122Ileus (HP:0002595)2.16080830
123Rough bone trabeculation (HP:0100670)2.14484674
124Recurrent bronchitis (HP:0002837)2.12541284
125Papillary thyroid carcinoma (HP:0002895)2.12539366
126Panhypogammaglobulinemia (HP:0003139)2.12478259
127Urticaria (HP:0001025)2.12405399
128Vascular calcification (HP:0004934)2.11304965
129Acne (HP:0001061)2.11233334
130Abnormality of renal resorption (HP:0011038)2.11092696
131Attenuation of retinal blood vessels (HP:0007843)2.10225834
132T lymphocytopenia (HP:0005403)2.09866443
133Increased IgE level (HP:0003212)2.09147142
134Chondrocalcinosis (HP:0000934)2.08507442
135Vertigo (HP:0002321)2.08419953
136Abnormality of the lumbar spine (HP:0100712)2.07984881
137Irritability (HP:0000737)2.07772198
138Rickets (HP:0002748)2.07625789
139Abnormal trabecular bone morphology (HP:0100671)2.06385999
140Facial diplegia (HP:0001349)2.05960187
141Abnormality of sodium homeostasis (HP:0010931)2.05407636
142Hemoptysis (HP:0002105)2.04870827
143Pulmonary infiltrates (HP:0002113)2.03379607
144Abnormality of liposaccharide metabolism (HP:0010968)2.03115228
145Abnormality of glycosphingolipid metabolism (HP:0004343)2.03115228
146Abnormality of glycolipid metabolism (HP:0010969)2.03115228
147Visual hallucinations (HP:0002367)2.02477803
148Abnormality of saccadic eye movements (HP:0000570)2.02078844
149Abnormality of T cell number (HP:0011839)2.02054704
150Bicornuate uterus (HP:0000813)2.01587238
151Dehydration (HP:0001944)2.01553848
152Hemiplegia (HP:0002301)2.00417294
153Widely patent fontanelles and sutures (HP:0004492)2.00063391
154Breast hypoplasia (HP:0003187)2.00038607
155Xanthomatosis (HP:0000991)1.99569015
156Eosinophilia (HP:0001880)1.99251373
157Abnormal rod and cone electroretinograms (HP:0008323)1.96262108
15811 pairs of ribs (HP:0000878)1.95250864
159Dysostosis multiplex (HP:0000943)1.93972459
160Abnormality of the columella (HP:0009929)1.93143648
161J-shaped sella turcica (HP:0002680)1.92980548
162Abnormality of alanine metabolism (HP:0010916)1.92725576
163Hyperalaninemia (HP:0003348)1.92725576
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92725576
165Inflammation of the large intestine (HP:0002037)1.92126460
166Abnormal enzyme/coenzyme activity (HP:0012379)1.91489503
167Abolished electroretinogram (ERG) (HP:0000550)1.91202934
168Abnormality of Sharpey fibers (HP:0100685)1.90971045
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90865801
170Athetosis (HP:0002305)1.90553888
171Hypoglycemic coma (HP:0001325)1.89890750
172Metabolic acidosis (HP:0001942)1.89789138
173Abnormal pancreas size (HP:0012094)1.89253015
174Abnormality of sulfur amino acid metabolism (HP:0004339)1.89198086
175Abnormality of alkaline phosphatase activity (HP:0004379)1.88475316
176Renal tubular dysfunction (HP:0000124)1.84418819
177Multiple enchondromatosis (HP:0005701)1.84347922
178Deformed sella turcica (HP:0002681)1.84035922
179Macrocytic anemia (HP:0001972)1.83611012
180Flared iliac wings (HP:0002869)1.83447048
181Hydroxyprolinuria (HP:0003080)1.83174211
182Abnormality of proline metabolism (HP:0010907)1.83174211
183Osteomyelitis (HP:0002754)1.82612652
184Keratitis (HP:0000491)1.82427386
185Cardiovascular calcification (HP:0011915)1.81848141
186Thoracic kyphosis (HP:0002942)1.80867037
187Abnormality of T cells (HP:0002843)1.80865030
188Malnutrition (HP:0004395)1.80680278
189Hepatic necrosis (HP:0002605)1.80396930
190Petechiae (HP:0000967)1.79217636
191Gastrointestinal inflammation (HP:0004386)1.78476775
192Thoracolumbar scoliosis (HP:0002944)1.77976666
193Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77696513
194Segmental peripheral demyelination/remyelination (HP:0003481)1.77552986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.69060963
2WNK45.51342920
3EPHA25.50043481
4RIPK44.88796289
5BUB14.67859627
6OXSR14.33825390
7WNK34.02851336
8WEE13.55678107
9NEK13.13859006
10STK392.79361877
11BLK2.62182600
12PNCK2.47390857
13EIF2AK12.33501556
14MAP2K32.31439223
15PRPF4B2.29057456
16IRAK42.26353681
17TTK2.21209648
18PDK32.21207927
19PDK42.21207927
20ZAK2.09234440
21STK162.04928475
22STK38L2.03579896
23TNK21.95550538
24AKT31.85577682
25BCKDK1.84439735
26PLK41.74942134
27NME11.70323413
28YES11.68308576
29PDK21.67580220
30CAMK41.67186596
31MAP3K21.62113709
32TSSK61.58125456
33NEK21.50376389
34NEK61.49053604
35NME21.48304810
36FES1.44033625
37JAK21.43241935
38IRAK31.40320503
39CSK1.38630169
40INSRR1.38318343
41TYK21.33297894
42MAPK121.30699219
43SYK1.29305604
44MAPK71.28091124
45MAP3K31.26700406
46MAP4K11.25479262
47FGR1.25370270
48BRSK21.17620503
49PTK2B1.15460871
50TXK1.13546703
51RPS6KA61.13523408
52MAP2K61.13393728
53MST41.13080270
54IRAK11.12996851
55HCK1.12792933
56NLK1.11703616
57PRKCI1.08995902
58UHMK11.08891440
59EIF2AK31.07997323
60MAP3K71.07855185
61LYN1.06954847
62CAMK11.03805412
63BTK1.03574702
64PINK11.02890154
65CAMKK11.02859915
66AURKA1.02193857
67RPS6KL11.01235999
68RPS6KC11.01235999
69TESK20.94892954
70STK380.94393063
71DYRK30.93071845
72SGK2230.93035789
73SGK4940.93035789
74RPS6KB20.92866779
75SRPK10.92619263
76ARAF0.88262580
77PLK10.87522739
78MARK20.86107701
79IKBKE0.85180183
80ABL20.84007105
81PIK3CG0.82724397
82PDK10.82024062
83MARK10.82019455
84PAK40.81732862
85PLK30.81306083
86RPS6KA50.79540202
87HIPK20.78674942
88IKBKB0.78322924
89MST1R0.78238058
90MAPK130.77916674
91LCK0.77539886
92NTRK30.75234354
93MAP3K80.74310635
94CHEK20.74091083
95STK110.72771451
96JAK10.72764411
97MAP2K20.69615187
98MARK30.69219526
99SGK10.68955550
100BRAF0.68669825
101BMPR20.68357322
102SCYL20.67817351
103DYRK1B0.67740916
104CDK120.65302497
105PAK10.64150100
106FGFR40.63898472
107AURKB0.63503361
108BRD40.62010396
109MAP3K10.60258121
110MAP3K110.59600088
111SIK20.58739272
112SGK30.57803003
113LRRK20.57435274
114DAPK20.57405665
115STK100.56993002
116BRSK10.53883504
117GRK60.51028245
118MAP2K40.50542514
119CAMK1D0.50222916
120KSR20.47175300
121RPS6KA10.47166115
122ERBB20.46054094
123CDK40.43921387
124MAPK40.43846072
125RET0.43000719
126ERN10.42007011
127PTK20.41958381
128NTRK20.41891205
129KDR0.41880621
130FYN0.41721162
131TEC0.41636325
132FGFR30.39832653
133TAOK10.39796399
134ITK0.39006261
135EPHA40.38782227
136NEK90.38393908
137JAK30.38110219
138TLK10.37754712
139MAP3K140.37455778
140SGK20.34234843
141CSNK1E0.33251034
142STK30.33129644
143LATS20.32600706
144MET0.31680986
145WNK10.30696735
146GSK3A0.29342811
147ACVR1B0.28662750
148FER0.25909239
149ZAP700.24986414
150PRKAA10.24536331
151TAOK20.24386573
152CAMKK20.24364421
153PRKCG0.21531205
154CAMK2G0.21452332
155PRKCD0.21412775
156CAMK2B0.20856523
157STK40.20808503
158CSNK1G10.20257318
159CHEK10.19698867
160PIM10.19674778
161PDPK10.18975564
162PAK30.18147448
163CCNB10.18004440
164MELK0.16937873
165MAP2K10.16797100
166CSNK2A10.16758262
167EPHB10.16460908
168PIM20.16042896
169AKT20.15953260
170CDK20.15348469
171PRKCZ0.15168575
172CSNK2A20.14872757
173IRAK20.13702495
174CDK70.13078105

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.23085262
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09839713
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.87066496
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83680363
5Osteoclast differentiation_Homo sapiens_hsa043802.77149123
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.62737612
7Vitamin digestion and absorption_Homo sapiens_hsa049772.56382920
8B cell receptor signaling pathway_Homo sapiens_hsa046622.50390956
9Butanoate metabolism_Homo sapiens_hsa006502.49880479
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44496931
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42062316
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34052088
13Propanoate metabolism_Homo sapiens_hsa006402.32093377
14Folate biosynthesis_Homo sapiens_hsa007902.30301262
15Leishmaniasis_Homo sapiens_hsa051402.15006016
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12513049
17Collecting duct acid secretion_Homo sapiens_hsa049662.12270300
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04208906
19Vitamin B6 metabolism_Homo sapiens_hsa007502.00811922
20Glutathione metabolism_Homo sapiens_hsa004801.99936765
21Regulation of autophagy_Homo sapiens_hsa041401.99917640
22Carbon metabolism_Homo sapiens_hsa012001.98765333
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98572660
24Tuberculosis_Homo sapiens_hsa051521.95714215
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95623874
26Pentose phosphate pathway_Homo sapiens_hsa000301.92829573
27T cell receptor signaling pathway_Homo sapiens_hsa046601.89532862
28Staphylococcus aureus infection_Homo sapiens_hsa051501.86163887
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85491379
30beta-Alanine metabolism_Homo sapiens_hsa004101.74128421
31Fructose and mannose metabolism_Homo sapiens_hsa000511.73338880
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71065520
33Fatty acid degradation_Homo sapiens_hsa000711.70878567
34Peroxisome_Homo sapiens_hsa041461.65170916
35Pyruvate metabolism_Homo sapiens_hsa006201.60024792
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59877511
37Systemic lupus erythematosus_Homo sapiens_hsa053221.59459033
38Long-term potentiation_Homo sapiens_hsa047201.55998924
39RNA polymerase_Homo sapiens_hsa030201.51550090
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.46042980
41Arginine and proline metabolism_Homo sapiens_hsa003301.45203485
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45133693
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43480348
44Malaria_Homo sapiens_hsa051441.43449837
45Hematopoietic cell lineage_Homo sapiens_hsa046401.41932275
46ABC transporters_Homo sapiens_hsa020101.40791380
47Chemokine signaling pathway_Homo sapiens_hsa040621.39805981
48Mineral absorption_Homo sapiens_hsa049781.38445792
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36208020
50Amphetamine addiction_Homo sapiens_hsa050311.31865726
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31331569
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29703728
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.28488976
54Tryptophan metabolism_Homo sapiens_hsa003801.27442282
55Alcoholism_Homo sapiens_hsa050341.27067389
56Olfactory transduction_Homo sapiens_hsa047401.25084268
57Oxidative phosphorylation_Homo sapiens_hsa001901.24355587
58VEGF signaling pathway_Homo sapiens_hsa043701.23864786
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.22967924
60Phagosome_Homo sapiens_hsa041451.22951625
61Dorso-ventral axis formation_Homo sapiens_hsa043201.22062906
62Ribosome_Homo sapiens_hsa030101.20019136
63Biosynthesis of amino acids_Homo sapiens_hsa012301.19451388
64Acute myeloid leukemia_Homo sapiens_hsa052211.18714010
65Renin secretion_Homo sapiens_hsa049241.18152056
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17928250
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.17054948
68Selenocompound metabolism_Homo sapiens_hsa004501.16250723
69Pyrimidine metabolism_Homo sapiens_hsa002401.15113420
70Renin-angiotensin system_Homo sapiens_hsa046141.14998145
71RNA transport_Homo sapiens_hsa030131.13692137
72Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13590490
73Non-small cell lung cancer_Homo sapiens_hsa052231.12633275
74Primary immunodeficiency_Homo sapiens_hsa053401.11990614
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10531522
76Fatty acid metabolism_Homo sapiens_hsa012121.09026311
77Taste transduction_Homo sapiens_hsa047421.09024825
78Other glycan degradation_Homo sapiens_hsa005111.06122167
79Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01870368
80Measles_Homo sapiens_hsa051621.00856156
81Viral carcinogenesis_Homo sapiens_hsa052031.00567977
82Glutamatergic synapse_Homo sapiens_hsa047240.99540733
83* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98471296
84Nitrogen metabolism_Homo sapiens_hsa009100.96443299
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.95871630
86Notch signaling pathway_Homo sapiens_hsa043300.95493458
87Graft-versus-host disease_Homo sapiens_hsa053320.95229252
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94245551
89Lysosome_Homo sapiens_hsa041420.93648216
90Glycerolipid metabolism_Homo sapiens_hsa005610.93424002
91Parkinsons disease_Homo sapiens_hsa050120.92282373
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92098738
93DNA replication_Homo sapiens_hsa030300.90949357
94Platelet activation_Homo sapiens_hsa046110.90459320
95Rheumatoid arthritis_Homo sapiens_hsa053230.89212145
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88783327
97TNF signaling pathway_Homo sapiens_hsa046680.87483125
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85915069
99Arginine biosynthesis_Homo sapiens_hsa002200.85741707
100Histidine metabolism_Homo sapiens_hsa003400.85392192
101Prolactin signaling pathway_Homo sapiens_hsa049170.85335694
102Inositol phosphate metabolism_Homo sapiens_hsa005620.83776526
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83754949
104One carbon pool by folate_Homo sapiens_hsa006700.82840386
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.82743054
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82725403
107Metabolic pathways_Homo sapiens_hsa011000.82095154
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81815704
109GABAergic synapse_Homo sapiens_hsa047270.80293586
110Oxytocin signaling pathway_Homo sapiens_hsa049210.80183021
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79228824
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78683513
113Choline metabolism in cancer_Homo sapiens_hsa052310.78308100
114Legionellosis_Homo sapiens_hsa051340.78112856
115Renal cell carcinoma_Homo sapiens_hsa052110.77541119
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77210115
117Calcium signaling pathway_Homo sapiens_hsa040200.76842299
118PPAR signaling pathway_Homo sapiens_hsa033200.76779587
119Circadian entrainment_Homo sapiens_hsa047130.76151506
120FoxO signaling pathway_Homo sapiens_hsa040680.75214608
121Cholinergic synapse_Homo sapiens_hsa047250.73585842
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73255627
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.72870516
124Endometrial cancer_Homo sapiens_hsa052130.72433571
125Chronic myeloid leukemia_Homo sapiens_hsa052200.72269243
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71469090
127Hepatitis B_Homo sapiens_hsa051610.71346691
128Synaptic vesicle cycle_Homo sapiens_hsa047210.71221073
129Influenza A_Homo sapiens_hsa051640.70032587
130Huntingtons disease_Homo sapiens_hsa050160.68650582
131Bile secretion_Homo sapiens_hsa049760.68391716
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.68011827
133Glioma_Homo sapiens_hsa052140.67881236
134Autoimmune thyroid disease_Homo sapiens_hsa053200.67303334
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66588958
136Morphine addiction_Homo sapiens_hsa050320.65403664
137Mismatch repair_Homo sapiens_hsa034300.65247505
138Galactose metabolism_Homo sapiens_hsa000520.64096966
139Estrogen signaling pathway_Homo sapiens_hsa049150.64045993
140Sphingolipid metabolism_Homo sapiens_hsa006000.63926716
141Arachidonic acid metabolism_Homo sapiens_hsa005900.63657444
142MAPK signaling pathway_Homo sapiens_hsa040100.63589006
143Toxoplasmosis_Homo sapiens_hsa051450.61725280
144African trypanosomiasis_Homo sapiens_hsa051430.61651535
145Cell cycle_Homo sapiens_hsa041100.61239785
146Spliceosome_Homo sapiens_hsa030400.61166446
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61034153
148Type II diabetes mellitus_Homo sapiens_hsa049300.60589433
149cAMP signaling pathway_Homo sapiens_hsa040240.60216891
150Allograft rejection_Homo sapiens_hsa053300.59876944
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.59812135
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59236742
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.58564396
154Nucleotide excision repair_Homo sapiens_hsa034200.58295022
155ErbB signaling pathway_Homo sapiens_hsa040120.58133814
156Fatty acid biosynthesis_Homo sapiens_hsa000610.57489970
157Sulfur relay system_Homo sapiens_hsa041220.56653844
158Phenylalanine metabolism_Homo sapiens_hsa003600.54294928
159GnRH signaling pathway_Homo sapiens_hsa049120.52891150
160Protein digestion and absorption_Homo sapiens_hsa049740.51594298
161Apoptosis_Homo sapiens_hsa042100.50262411
162Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49511560
163Pancreatic cancer_Homo sapiens_hsa052120.48851478
164Purine metabolism_Homo sapiens_hsa002300.48412623
165Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48122982
166Lysine degradation_Homo sapiens_hsa003100.47390632
167Tight junction_Homo sapiens_hsa045300.46381352
168Fatty acid elongation_Homo sapiens_hsa000620.46325472
169Starch and sucrose metabolism_Homo sapiens_hsa005000.45616489
170Base excision repair_Homo sapiens_hsa034100.45446324
171Retinol metabolism_Homo sapiens_hsa008300.45299559
172Steroid biosynthesis_Homo sapiens_hsa001000.44602841
173Sulfur metabolism_Homo sapiens_hsa009200.43924061
174Vibrio cholerae infection_Homo sapiens_hsa051100.43306201
175Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43175135
176Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42821545
177Homologous recombination_Homo sapiens_hsa034400.41490522
178p53 signaling pathway_Homo sapiens_hsa041150.36651343
179Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34344743
180Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34198804
181Primary bile acid biosynthesis_Homo sapiens_hsa001200.34150437
182Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33880227
183Maturity onset diabetes of the young_Homo sapiens_hsa049500.31148168
184Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29041439
185Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27516594
186Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27190344
187Chemical carcinogenesis_Homo sapiens_hsa052040.23354910

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