TRPC4AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)4.06177659
2protein retention in ER lumen (GO:0006621)3.99808627
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98570277
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98570277
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87441328
6protein localization to endosome (GO:0036010)3.80189648
7positive regulation of histone deacetylation (GO:0031065)3.75827508
8regulation of gamma-delta T cell differentiation (GO:0045586)3.75014560
9COPI coating of Golgi vesicle (GO:0048205)3.66783365
10Golgi transport vesicle coating (GO:0048200)3.66783365
11regulation of cholesterol homeostasis (GO:2000188)3.59979320
12positive regulation of gamma-delta T cell activation (GO:0046645)3.59414189
13regulation of fatty acid beta-oxidation (GO:0031998)3.56161896
14negative regulation of cell size (GO:0045792)3.48182013
15antigen processing and presentation of endogenous antigen (GO:0019883)3.47456563
16pinocytosis (GO:0006907)3.46561786
17valine metabolic process (GO:0006573)3.32944187
18response to laminar fluid shear stress (GO:0034616)3.31903125
192-oxoglutarate metabolic process (GO:0006103)3.31375688
20regulation of gamma-delta T cell activation (GO:0046643)3.29333466
21sodium ion export (GO:0071436)3.27798328
22barbed-end actin filament capping (GO:0051016)3.26194401
23positive regulation of triglyceride biosynthetic process (GO:0010867)3.25758519
24embryonic process involved in female pregnancy (GO:0060136)3.16211353
25tricarboxylic acid metabolic process (GO:0072350)3.12630531
26proline biosynthetic process (GO:0006561)3.12394474
27regulation of ARF protein signal transduction (GO:0032012)3.08855444
28macroautophagy (GO:0016236)3.04911408
29lysine metabolic process (GO:0006553)3.01993177
30lysine catabolic process (GO:0006554)3.01993177
31negative regulation of cell killing (GO:0031342)3.01679373
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01679373
33basement membrane organization (GO:0071711)3.01469853
34regulation of extracellular matrix disassembly (GO:0010715)3.01422960
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.99366720
36mannose metabolic process (GO:0006013)2.99312986
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98696685
38antigen processing and presentation via MHC class Ib (GO:0002475)2.97964217
39regulation of ARF GTPase activity (GO:0032312)2.97935095
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97867543
41focal adhesion assembly (GO:0048041)2.96196477
42cell-substrate adherens junction assembly (GO:0007045)2.96196477
43glucose 6-phosphate metabolic process (GO:0051156)2.95930837
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.91743243
45adherens junction assembly (GO:0034333)2.90787878
46dicarboxylic acid biosynthetic process (GO:0043650)2.89929922
47peptidyl-lysine dimethylation (GO:0018027)2.85414708
48positive regulation of fatty acid beta-oxidation (GO:0032000)2.85001767
49response to muramyl dipeptide (GO:0032495)2.83782379
50negative regulation of erythrocyte differentiation (GO:0045647)2.83700696
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83625836
52regulation of cholesterol storage (GO:0010885)2.82830364
53positive regulation of nuclease activity (GO:0032075)2.77665176
54growth hormone receptor signaling pathway (GO:0060396)2.77458353
55regulation of NFAT protein import into nucleus (GO:0051532)2.77097509
56synaptic vesicle maturation (GO:0016188)2.76420349
57pentose-phosphate shunt (GO:0006098)2.76115387
58negative regulation of lipid transport (GO:0032369)2.75375910
59cell-substrate junction assembly (GO:0007044)2.75156044
60protein-lipid complex assembly (GO:0065005)2.74642874
61positive regulation of triglyceride metabolic process (GO:0090208)2.73107973
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73042437
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71277872
64cerebellar Purkinje cell layer development (GO:0021680)2.69971547
65sexual reproduction (GO:0019953)2.69654853
66modulation by symbiont of host cellular process (GO:0044068)2.68644184
67regulation of fatty acid oxidation (GO:0046320)2.67572634
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65533105
69plasma lipoprotein particle assembly (GO:0034377)2.64246963
70oxaloacetate metabolic process (GO:0006107)2.62961166
71skin morphogenesis (GO:0043589)2.62706343
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60336352
73regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.60208240
74stress fiber assembly (GO:0043149)2.58314355
754-hydroxyproline metabolic process (GO:0019471)2.58046484
76hypotonic response (GO:0006971)2.57675709
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.57346206
78low-density lipoprotein particle clearance (GO:0034383)2.56451451
79positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.56195904
80positive regulation of protein deacetylation (GO:0090312)2.55096885
813-UTR-mediated mRNA stabilization (GO:0070935)2.54822576
82negative regulation of fibrinolysis (GO:0051918)2.54578063
83apoptotic cell clearance (GO:0043277)2.53535435
84positive thymic T cell selection (GO:0045059)2.52320183
85peptidyl-proline hydroxylation (GO:0019511)2.51701917
86regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51690978
87maternal placenta development (GO:0001893)2.51354654
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51059937
89plasma membrane repair (GO:0001778)2.49242435
90positive regulation of extracellular matrix organization (GO:1903055)2.49204998
91positive regulation of glycogen biosynthetic process (GO:0045725)2.49128620
92regulation of cholesterol biosynthetic process (GO:0045540)2.48810460
93carnitine shuttle (GO:0006853)2.48180404
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46969362
95cellular modified amino acid catabolic process (GO:0042219)2.46859191
96activation of protein kinase A activity (GO:0034199)2.46815599
97fatty acid transmembrane transport (GO:1902001)2.46527753
98positive regulation of fatty acid biosynthetic process (GO:0045723)2.46500920
99glucose catabolic process (GO:0006007)2.46108999
100natural killer cell differentiation (GO:0001779)2.45539821
101histone H3-K36 demethylation (GO:0070544)2.45476713
102regulation of extracellular matrix organization (GO:1903053)2.44767435
103vesicle coating (GO:0006901)2.44681865
104regulation of nuclease activity (GO:0032069)2.44601953
105negative regulation of sterol transport (GO:0032372)2.43722624
106negative regulation of cholesterol transport (GO:0032375)2.43722624
107proline metabolic process (GO:0006560)2.43015830
108positive regulation of lipid catabolic process (GO:0050996)2.42568553
109cellular response to growth hormone stimulus (GO:0071378)2.42235985
110positive regulation by symbiont of host defense response (GO:0052509)2.41687628
111modulation by symbiont of host defense response (GO:0052031)2.41687628
112modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41687628
113modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41687628
114positive regulation by organism of defense response of other organism involved in symbiotic interact2.41687628
115modulation by symbiont of host immune response (GO:0052553)2.41687628
116urea metabolic process (GO:0019627)2.41176192
117urea cycle (GO:0000050)2.41176192
118endoplasmic reticulum unfolded protein response (GO:0030968)2.40814651
119regulation of lipid catabolic process (GO:0050994)2.40286032
120protein hydroxylation (GO:0018126)2.39520526
121cell communication by electrical coupling (GO:0010644)2.39071997
122positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38944095
123NADPH regeneration (GO:0006740)2.38882780
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.38451550
125regulation of response to osmotic stress (GO:0047484)2.38430750
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.38214851
127L-phenylalanine metabolic process (GO:0006558)2.38214851
128kynurenine metabolic process (GO:0070189)2.37374646
129cell adhesion mediated by integrin (GO:0033627)2.37358000
130apoptotic process involved in morphogenesis (GO:0060561)2.37263450
131negative regulation of necroptotic process (GO:0060546)2.35874155
132aspartate family amino acid catabolic process (GO:0009068)2.35446333
133retrograde transport, endosome to Golgi (GO:0042147)2.34949833
134ER-nucleus signaling pathway (GO:0006984)2.34435434
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34176048
136locomotory exploration behavior (GO:0035641)2.33733655
137negative regulation of fatty acid transport (GO:2000192)2.33531445
138response to peptidoglycan (GO:0032494)2.33455116
139L-phenylalanine catabolic process (GO:0006559)2.32786978
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32786978
141COPII vesicle coating (GO:0048208)2.32502677
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.31789123
143regulation of apoptotic cell clearance (GO:2000425)2.31505687
144dosage compensation (GO:0007549)2.31371621
145receptor catabolic process (GO:0032801)2.31284121
146modulation by virus of host process (GO:0019054)2.31158449
147regulation of triglyceride biosynthetic process (GO:0010866)2.29579035
148cortical actin cytoskeleton organization (GO:0030866)2.29471376
149cellular response to unfolded protein (GO:0034620)2.29151894
150layer formation in cerebral cortex (GO:0021819)2.28998176
151cellular hyperosmotic response (GO:0071474)2.28450049
152regulation of early endosome to late endosome transport (GO:2000641)2.28277586
153glutamate metabolic process (GO:0006536)2.28268778
154regulation of translational termination (GO:0006449)2.28096618
155regulation of defense response to virus by virus (GO:0050690)2.27625746
156sulfur amino acid catabolic process (GO:0000098)2.26189350
157alanine transport (GO:0032328)2.25764144
158regulation of triglyceride catabolic process (GO:0010896)2.25726508
159regulation of type I interferon-mediated signaling pathway (GO:0060338)2.25608606
160regulation of T-helper 2 cell differentiation (GO:0045628)2.25478221
161cell-cell junction maintenance (GO:0045217)2.24853276
162positive regulation of phagocytosis (GO:0050766)2.24477104
163activation of Rac GTPase activity (GO:0032863)2.23511015
164very-low-density lipoprotein particle assembly (GO:0034379)2.22473653
165histone H4 deacetylation (GO:0070933)2.20873078
166modulation by virus of host morphology or physiology (GO:0019048)2.20543512
167glycolytic process (GO:0006096)2.18967714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.82001519
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25513168
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00707481
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.75147624
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.74908985
6MYC_22102868_ChIP-Seq_BL_Human2.74348676
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65349361
8KDM2B_26808549_Chip-Seq_DND41_Human2.44562867
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38910785
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.37567955
11LXR_22292898_ChIP-Seq_THP-1_Human2.29763655
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.28783261
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22628574
14TCF7_22412390_ChIP-Seq_EML_Mouse2.22588782
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16508125
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13322505
17VDR_21846776_ChIP-Seq_THP-1_Human2.12000354
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.07830709
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99057982
20CLOCK_20551151_ChIP-Seq_293T_Human1.95135471
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.93142484
22ZNF263_19887448_ChIP-Seq_K562_Human1.89860326
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85632068
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81886888
25UTX_26944678_Chip-Seq_JUKART_Human1.79991883
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76331085
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75860900
28MAF_26560356_Chip-Seq_TH1_Human1.75316589
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71198276
30KDM2B_26808549_Chip-Seq_K562_Human1.67784167
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65939548
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65761798
33RACK7_27058665_Chip-Seq_MCF-7_Human1.63144023
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63123071
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62648524
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.61201980
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.61162538
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59872954
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58091975
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56415917
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55896568
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55863251
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49398968
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49229194
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46969376
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45609899
47SPI1_23127762_ChIP-Seq_K562_Human1.44486908
48* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44408593
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.43880111
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43489957
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39882531
52GATA1_19941826_ChIP-Seq_K562_Human1.39095896
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38986572
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38714644
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37694080
56* P68_20966046_ChIP-Seq_HELA_Human1.36698320
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36104214
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34211261
59VDR_24763502_ChIP-Seq_THP-1_Human1.34065652
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33189777
61FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.32922731
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32074598
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31936094
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30641231
65CREB1_26743006_Chip-Seq_LNCaP_Human1.29538145
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.29186342
67* SMC4_20622854_ChIP-Seq_HELA_Human1.27836695
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26940917
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26785358
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26757654
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25408691
72* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24860222
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24327104
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24326986
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23899957
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.21078539
77RUNX_20019798_ChIP-Seq_JUKART_Human1.20757027
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20497694
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20104103
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20052241
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19077160
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19073891
83MAF_26560356_Chip-Seq_TH2_Human1.18942182
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18745382
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17914689
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.17792046
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.17792046
88TP53_22127205_ChIP-Seq_IMR90_Human1.17563761
89* MYB_26560356_Chip-Seq_TH2_Human1.16636711
90BCOR_27268052_Chip-Seq_Bcells_Human1.16413965
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15866192
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15123697
93ATF3_27146783_Chip-Seq_COLON_Human1.14901694
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.13671436
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12659414
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.12580932
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12093973
98BCL6_27268052_Chip-Seq_Bcells_Human1.11441522
99NCOR1_26117541_ChIP-Seq_K562_Human1.10860705
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10780788
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10652905
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10595535
103* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10448962
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10376134
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09938124
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09662644
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08750321
108FOXA2_19822575_ChIP-Seq_HepG2_Human1.08723469
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08251876
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.07361094
111MYB_26560356_Chip-Seq_TH1_Human1.07108498
112SCL_19346495_ChIP-Seq_HPC-7_Human1.05951087
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.05424891
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05111306
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.03903390
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03725878
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.03716733
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.03099052
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03096735
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02257517
121* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99700397
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99685068
123GATA3_27048872_Chip-Seq_THYMUS_Human0.98461520
124CTCF_21964334_Chip-Seq_Bcells_Human0.98396606
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97360895
126TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96704097
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95998953
128* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95752243
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95615473
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95022543
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94712744
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93964600
133DROSHA_22980978_ChIP-Seq_HELA_Human0.93648991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.86824734
2MP0008260_abnormal_autophagy3.50543118
3MP0009840_abnormal_foam_cell3.30501393
4MP0002139_abnormal_hepatobiliary_system3.18095981
5MP0003705_abnormal_hypodermis_morpholog3.12514612
6MP0003300_gastrointestinal_ulcer3.05735425
7MP0004130_abnormal_muscle_cell2.57758023
8MP0005365_abnormal_bile_salt2.47396741
9MP0005360_urolithiasis2.39425226
10MP0003303_peritoneal_inflammation2.27479328
11MP0005083_abnormal_biliary_tract2.26340490
12MP0002909_abnormal_adrenal_gland2.22983337
13MP0005058_abnormal_lysosome_morphology2.21585020
14MP0003191_abnormal_cellular_cholesterol2.16202319
15MP0008961_abnormal_basal_metabolism2.13538171
16MP0010329_abnormal_lipoprotein_level2.04910928
17MP0004510_myositis2.04025641
18MP0003252_abnormal_bile_duct2.01675776
19MP0004272_abnormal_basement_membrane1.83306043
20MP0004859_abnormal_synaptic_plasticity1.82567377
21MP0003329_amyloid_beta_deposits1.82347361
22MP0005085_abnormal_gallbladder_physiolo1.81317120
23MP0003172_abnormal_lysosome_physiology1.78138534
24MP0010234_abnormal_vibrissa_follicle1.77477527
25MP0000685_abnormal_immune_system1.72523946
26MP0005257_abnormal_intraocular_pressure1.70926886
27MP0004858_abnormal_nervous_system1.67805922
28MP0000858_altered_metastatic_potential1.63330391
29MP0000604_amyloidosis1.62829658
30MP0000013_abnormal_adipose_tissue1.62073166
31MP0004233_abnormal_muscle_weight1.62052828
32MP0009278_abnormal_bone_marrow1.59052134
33MP0001915_intracranial_hemorrhage1.58761085
34MP0000609_abnormal_liver_physiology1.58309608
35MP0003221_abnormal_cardiomyocyte_apopto1.57436353
36MP0005409_darkened_coat_color1.55976797
37MP0004947_skin_inflammation1.52477795
38MP0004185_abnormal_adipocyte_glucose1.48226434
39MP0002837_dystrophic_cardiac_calcinosis1.44174019
40MP0005076_abnormal_cell_differentiation1.43714269
41MP0005464_abnormal_platelet_physiology1.43467750
42MP0002118_abnormal_lipid_homeostasis1.37914901
43MP0005375_adipose_tissue_phenotype1.37246831
44MP0000003_abnormal_adipose_tissue1.36609463
45MP0005666_abnormal_adipose_tissue1.35200765
46MP0003075_altered_response_to1.34328712
47MP0002877_abnormal_melanocyte_morpholog1.33928721
48MP0003724_increased_susceptibility_to1.30279154
49MP0003453_abnormal_keratinocyte_physiol1.29417420
50MP0000751_myopathy1.28713834
51MP0001666_abnormal_nutrient_absorption1.28213458
52MP0005023_abnormal_wound_healing1.28144386
53MP0000747_muscle_weakness1.26760233
54MP0003828_pulmonary_edema1.21793960
55MP0002998_abnormal_bone_remodeling1.21176138
56MP0003436_decreased_susceptibility_to1.20902643
57MP0001348_abnormal_lacrimal_gland1.20484729
58MP0003045_fibrosis1.18708164
59MP0005584_abnormal_enzyme/coenzyme_acti1.16989779
60MP0002269_muscular_atrophy1.16844881
61MP0004087_abnormal_muscle_fiber1.16188278
62MP0000767_abnormal_smooth_muscle1.16107486
63MP0003122_maternal_imprinting1.15232913
64MP0005670_abnormal_white_adipose1.13808616
65MP0003183_abnormal_peptide_metabolism1.12164993
66MP0001849_ear_inflammation1.11737806
67MP0005319_abnormal_enzyme/_coenzyme1.07935467
68MP0005167_abnormal_blood-brain_barrier1.06609357
69MP0008438_abnormal_cutaneous_collagen1.04338133
70MP0005332_abnormal_amino_acid1.03482275
71MP0006054_spinal_hemorrhage1.01450801
72MP0005621_abnormal_cell_physiology1.01344166
73MP0002060_abnormal_skin_morphology1.00652039
74MP0004264_abnormal_extraembryonic_tissu1.00513966
75MP0000569_abnormal_digit_pigmentation1.00064128
76MP0003566_abnormal_cell_adhesion0.98654317
77MP0003279_aneurysm0.97459069
78MP0003763_abnormal_thymus_physiology0.97384915
79MP0008875_abnormal_xenobiotic_pharmacok0.97100572
80MP0001835_abnormal_antigen_presentation0.96965470
81MP0003195_calcinosis0.96614825
82MP0001545_abnormal_hematopoietic_system0.96433694
83MP0005397_hematopoietic_system_phenotyp0.96433694
84MP0002166_altered_tumor_susceptibility0.96277982
85MP0002078_abnormal_glucose_homeostasis0.94295162
86MP0010352_gastrointestinal_tract_polyps0.93543070
87MP0006082_CNS_inflammation0.93520716
88MP0001790_abnormal_immune_system0.92341718
89MP0005387_immune_system_phenotype0.92341718
90MP0009780_abnormal_chondrocyte_physiolo0.91163761
91MP0001958_emphysema0.90730463
92MP0000598_abnormal_liver_morphology0.90293179
93MP0003091_abnormal_cell_migration0.89418917
94MP0001730_embryonic_growth_arrest0.88004611
95MP0009384_cardiac_valve_regurgitation0.87810788
96MP0001853_heart_inflammation0.87146163
97MP0000759_abnormal_skeletal_muscle0.86931341
98MP0009643_abnormal_urine_homeostasis0.86907430
99MP0001800_abnormal_humoral_immune0.86645119
100MP0010368_abnormal_lymphatic_system0.84980881
101MP0002896_abnormal_bone_mineralization0.83145210
102MP0008469_abnormal_protein_level0.82838580
103MP0003634_abnormal_glial_cell0.82749004
104MP0000733_abnormal_muscle_development0.82543084
105MP0000920_abnormal_myelination0.81588488
106MP0001851_eye_inflammation0.80864965
107MP0002971_abnormal_brown_adipose0.80697666
108MP0005623_abnormal_meninges_morphology0.80522332
109MP0003646_muscle_fatigue0.80400578
110MP0000750_abnormal_muscle_regeneration0.78708815
111MP0005166_decreased_susceptibility_to0.78694515
112MP0003866_abnormal_defecation0.78600974
113MP0005535_abnormal_body_temperature0.78543029
114MP0002138_abnormal_hepatobiliary_system0.78518763
115MP0002419_abnormal_innate_immunity0.77987726
116MP0001533_abnormal_skeleton_physiology0.77918327
117MP0002933_joint_inflammation0.77199833
118MP0003690_abnormal_glial_cell0.77157349
119MP0001845_abnormal_inflammatory_respons0.76968628
120MP0002723_abnormal_immune_serum0.76929157
121MP0002089_abnormal_postnatal_growth/wei0.76382258
122MP0005000_abnormal_immune_tolerance0.76212117
123MP0008569_lethality_at_weaning0.76168913
124MP0002398_abnormal_bone_marrow0.75870282
125MP0003633_abnormal_nervous_system0.75859181
126MP0002452_abnormal_antigen_presenting0.75136664
127MP0003656_abnormal_erythrocyte_physiolo0.75107574
128MP0005025_abnormal_response_to0.74901504
129MP0005334_abnormal_fat_pad0.74797844
130MP0010155_abnormal_intestine_physiology0.74363582
131MP0010630_abnormal_cardiac_muscle0.73776604
132MP0001765_abnormal_ion_homeostasis0.73195064
133MP0009333_abnormal_splenocyte_physiolog0.72551563
134MP0001756_abnormal_urination0.72019987
135MP0005164_abnormal_response_to0.71710149
136MP0005390_skeleton_phenotype0.71191541
137MP0001243_abnormal_dermal_layer0.71182558
138MP0005384_cellular_phenotype0.69804217
139MP0009785_altered_susceptibility_to0.69229020
140MP0003115_abnormal_respiratory_system0.69227387
141MP0000465_gastrointestinal_hemorrhage0.68943770
142MP0001614_abnormal_blood_vessel0.68868922
143MP0003795_abnormal_bone_structure0.67958274
144MP0002405_respiratory_system_inflammati0.67038199
145MP0001819_abnormal_immune_cell0.65439748
146MP0003448_altered_tumor_morphology0.65053843
147MP0002420_abnormal_adaptive_immunity0.64136950
148MP0002254_reproductive_system_inflammat0.63583409

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.36343018
2Hyperacusis (HP:0010780)3.35317122
3Deep venous thrombosis (HP:0002625)3.14426774
4Vertebral compression fractures (HP:0002953)3.09163341
5Cerebral aneurysm (HP:0004944)2.86201111
6Flat acetabular roof (HP:0003180)2.77184615
7Abnormality of the lower motor neuron (HP:0002366)2.68614647
8Eczematoid dermatitis (HP:0000976)2.64748661
9Abnormality of the Achilles tendon (HP:0005109)2.57216114
10Insomnia (HP:0100785)2.54478259
11Xanthomatosis (HP:0000991)2.53680153
12Cholecystitis (HP:0001082)2.50792247
13Abnormal gallbladder physiology (HP:0012438)2.50792247
14Cervical subluxation (HP:0003308)2.50165989
15Achilles tendon contracture (HP:0001771)2.49331179
16Difficulty running (HP:0009046)2.46559436
17Asymmetric septal hypertrophy (HP:0001670)2.46456118
18Increased cerebral lipofuscin (HP:0011813)2.46124115
19Distal lower limb amyotrophy (HP:0008944)2.43061970
20Distal upper limb amyotrophy (HP:0007149)2.42371411
21Upper limb amyotrophy (HP:0009129)2.42371411
22Elfin facies (HP:0004428)2.38705043
23Supranuclear gaze palsy (HP:0000605)2.35854521
24Bundle branch block (HP:0011710)2.35726498
25Macroorchidism (HP:0000053)2.32198829
26Enlarged penis (HP:0000040)2.31284984
27Hand muscle atrophy (HP:0009130)2.30494331
28Complement deficiency (HP:0004431)2.30305637
29Neurofibrillary tangles (HP:0002185)2.29998726
30Broad metatarsal (HP:0001783)2.26399139
31Increased connective tissue (HP:0009025)2.26309555
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.25882054
33Broad face (HP:0000283)2.24669976
34Long toe (HP:0010511)2.20538468
35Peritonitis (HP:0002586)2.20430684
36Disproportionate tall stature (HP:0001519)2.19846600
37Back pain (HP:0003418)2.19545894
38Myoglobinuria (HP:0002913)2.15167448
39Shallow orbits (HP:0000586)2.14334194
40Renovascular hypertension (HP:0100817)2.13000519
41Myocardial infarction (HP:0001658)2.12601502
42Aneurysm (HP:0002617)2.11243967
43Bladder diverticulum (HP:0000015)2.10104434
44Ketosis (HP:0001946)2.07649785
45Frequent falls (HP:0002359)2.07109867
46Abnormality of macrophages (HP:0004311)2.07083476
47Difficulty climbing stairs (HP:0003551)2.06659430
48Abnormality of glycolipid metabolism (HP:0010969)2.05811263
49Abnormality of liposaccharide metabolism (HP:0010968)2.05811263
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.05811263
51Abnormality of polysaccharide metabolism (HP:0011012)2.05563167
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05563167
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05563167
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03863577
55Striae distensae (HP:0001065)2.03680903
56Overriding aorta (HP:0002623)2.03585960
57Polycythemia (HP:0001901)2.02953403
58Amyloidosis (HP:0011034)2.01466838
59Biconcave vertebral bodies (HP:0004586)2.00961985
60Exercise-induced myalgia (HP:0003738)2.00439982
61Turricephaly (HP:0000262)1.98352521
62Hemiplegia (HP:0002301)1.97039443
63Thin bony cortex (HP:0002753)1.96803520
64Protrusio acetabuli (HP:0003179)1.96039407
65Wormian bones (HP:0002645)1.95846968
66Mitral valve prolapse (HP:0001634)1.94913606
67Neuronal loss in central nervous system (HP:0002529)1.94321967
68Abnormality of carpal bone ossification (HP:0006257)1.94077729
69Abnormality of the common coagulation pathway (HP:0010990)1.93978170
70Lymphangioma (HP:0100764)1.93179150
71Global brain atrophy (HP:0002283)1.92529285
72Arterial tortuosity (HP:0005116)1.91590133
73Stridor (HP:0010307)1.91488808
74Loss of speech (HP:0002371)1.90284319
75Vascular tortuosity (HP:0004948)1.89340998
76Abnormal ossification of hand bones (HP:0005921)1.89233030
77Thoracic kyphosis (HP:0002942)1.89168520
78Atrophic scars (HP:0001075)1.88615184
79Ulnar bowing (HP:0003031)1.87404929
80Dilatation of the ascending aorta (HP:0005111)1.86874853
81Spinal rigidity (HP:0003306)1.86547364
82Blue sclerae (HP:0000592)1.85382680
83Mitral regurgitation (HP:0001653)1.84383901
84Interstitial pulmonary disease (HP:0006530)1.83953446
85Hyperlipoproteinemia (HP:0010980)1.83931708
86Atrioventricular block (HP:0001678)1.83335466
87Polygenic inheritance (HP:0010982)1.83318245
88Ketoacidosis (HP:0001993)1.82626188
89Long palpebral fissure (HP:0000637)1.81779059
90Dysostosis multiplex (HP:0000943)1.81628883
91Cellulitis (HP:0100658)1.81494454
92Bowel diverticulosis (HP:0005222)1.81107536
93Hematochezia (HP:0002573)1.80954144
94Dysmetric saccades (HP:0000641)1.80062669
95Pointed chin (HP:0000307)1.79273731
96Broad palm (HP:0001169)1.78520431
97Increased variability in muscle fiber diameter (HP:0003557)1.77974690
98Gout (HP:0001997)1.76863224
99Stroke (HP:0001297)1.76216974
100Distal lower limb muscle weakness (HP:0009053)1.75108322
101Cerebral inclusion bodies (HP:0100314)1.75000589
102Impaired social interactions (HP:0000735)1.74960447
103Abnormal social behavior (HP:0012433)1.74960447
104Abnormality of the acetabulum (HP:0003170)1.74823036
105Ankle clonus (HP:0011448)1.74679627
106Hammertoe (HP:0001765)1.73835402
107Type 1 muscle fiber predominance (HP:0003803)1.73715887
108Obstructive sleep apnea (HP:0002870)1.72354562
109Hyporeflexia of lower limbs (HP:0002600)1.72107261
110Hypoglycemic coma (HP:0001325)1.71688285
111Late onset (HP:0003584)1.71580161
112Aortic dissection (HP:0002647)1.70135585
113Metaphyseal cupping (HP:0003021)1.70127295
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.69778942
115Hypercortisolism (HP:0001578)1.69697780
116Amyotrophic lateral sclerosis (HP:0007354)1.69259042
117Mildly elevated creatine phosphokinase (HP:0008180)1.69150353
118Peripheral hypomyelination (HP:0007182)1.68799546
119Reticulocytosis (HP:0001923)1.68625787
120Lower limb amyotrophy (HP:0007210)1.67868415
121Hyperammonemia (HP:0001987)1.67779802
122Mitral stenosis (HP:0001718)1.67637544
123Rapidly progressive (HP:0003678)1.67522345
124Neonatal onset (HP:0003623)1.67445638
125Segmental peripheral demyelination/remyelination (HP:0003481)1.67128478
126Abnormality of the thoracic spine (HP:0100711)1.66939010
127Visual hallucinations (HP:0002367)1.66920147
128Abnormality of skeletal muscle fiber size (HP:0012084)1.66568145
129T lymphocytopenia (HP:0005403)1.65742101
130Urinary glycosaminoglycan excretion (HP:0003541)1.64629092
131Mucopolysacchariduria (HP:0008155)1.64629092
132Asymmetry of the thorax (HP:0001555)1.64469340
133Facial diplegia (HP:0001349)1.64080020
134Intrahepatic cholestasis (HP:0001406)1.64053782
135Abnormality of monocarboxylic acid metabolism (HP:0010996)1.64002517
136Fragile skin (HP:0001030)1.63982653
137Torticollis (HP:0000473)1.63166221
138Abnormality of the nasal mucosa (HP:0000433)1.63104919
139Abnormality of complement system (HP:0005339)1.63023324
140Resting tremor (HP:0002322)1.61339300
141Systemic lupus erythematosus (HP:0002725)1.61204547
142Sensorimotor neuropathy (HP:0007141)1.61103136
143Abnormality of the intrinsic pathway (HP:0010989)1.61080843
144Abnormality of the lumbar spine (HP:0100712)1.61030428
145Cardiomegaly (HP:0001640)1.60904767
146Depression (HP:0000716)1.60606693
147Spastic tetraparesis (HP:0001285)1.60532674
148Ankle contracture (HP:0006466)1.60343346
149Aortic aneurysm (HP:0004942)1.60207477
150Upper motor neuron abnormality (HP:0002127)1.60158169
151Coxa vara (HP:0002812)1.59765425
152Ulnar deviation of the wrist (HP:0003049)1.59705337
153Axonal loss (HP:0003447)1.59487633
154Hemorrhage of the eye (HP:0011885)1.59350493
155Hypercholesterolemia (HP:0003124)1.59233759
156Abnormality of the peritoneum (HP:0002585)1.58924068
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57528136
158Apathy (HP:0000741)1.57081275
159Joint laxity (HP:0001388)1.54573200
160Increased IgE level (HP:0003212)1.54541322
161Short nail (HP:0001799)1.53866707
162Abnormality of oral frenula (HP:0000190)1.52087543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.37067616
2PKN23.93771518
3PRPF4B3.12621219
4EEF2K3.04687634
5ERN13.03969380
6MAP3K102.45641903
7FGFR42.31489806
8CDK122.29203689
9PTK62.14882330
10SMG12.12759138
11TTN2.07843196
12RIPK11.98712096
13KSR21.89766746
14SIK11.86190783
15MAP4K11.75508112
16BCKDK1.74035033
17PRKD31.72025371
18EPHB11.61333948
19CAMKK11.57539290
20TYK21.53933731
21MAP3K91.47973775
22RET1.42925090
23TBK11.41910758
24TAOK11.40987563
25PRKCH1.39783386
26PDGFRA1.38699963
27ALK1.37144534
28LRRK21.35137832
29JAK11.30660351
30SCYL21.28133082
31MAP3K61.27039649
32MAP3K71.20725895
33TAOK21.19154679
34SIK21.18746646
35DDR21.14738704
36LMTK21.11546994
37ZAP701.09837893
38CAMK1G1.07878578
39MARK11.07393841
40IRAK31.07025718
41JAK31.06557112
42JAK21.04667404
43MAP3K31.03515789
44TYRO31.02239321
45CAMK1D1.00379114
46ARAF0.96526099
47EPHA20.95621097
48MAP3K110.95362139
49MAP3K140.95276930
50STK380.93733527
51SIK30.90563207
52PAK60.88406469
53FGFR30.87602227
54ICK0.87399163
55BMX0.83868750
56FGR0.83050965
57MAP2K30.81472976
58MAP3K20.81297845
59PHKG20.80063997
60PHKG10.80063997
61FLT30.79880162
62PDK10.79208967
63GRK60.78897070
64HCK0.78018894
65DAPK20.77635108
66MAP3K130.76084815
67KIT0.75641936
68PDGFRB0.74485913
69DYRK1B0.74345117
70IRAK40.72938692
71MAP3K10.72581724
72PDK40.71723497
73PDK30.71723497
74NEK90.71405521
75MTOR0.71008204
76CSF1R0.70933215
77PTK20.69097191
78RPS6KA20.68189463
79CAMKK20.66954573
80PAK40.66911528
81NME20.66902552
82PDPK10.62617391
83SGK30.62604346
84TESK20.62418612
85MARK20.62292722
86MOS0.61472903
87TGFBR20.61389709
88TAOK30.59562562
89DMPK0.58720648
90PRKD10.58608969
91MAPK120.58227089
92BLK0.58019937
93MST1R0.57729810
94PIM20.57344179
95FES0.57044987
96KSR10.56646106
97KDR0.56246368
98CDK60.56151208
99MAP2K40.55630591
100LATS20.55407196
101ITK0.54823337
102MAPK110.54252935
103NEK10.52716200
104CLK10.52641469
105MET0.52392437
106CDC42BPA0.51915234
107NTRK30.51461701
108LIMK10.51101371
109SYK0.50434403
110IKBKE0.48455957
111TESK10.48320759
112CSK0.47519193
113BTK0.46755886
114MAP3K80.46041816
115HIPK20.44732710
116EPHA30.44673492
117FGFR20.44538836
118RAF10.44386098
119MATK0.43755317
120RPS6KC10.43344923
121RPS6KL10.43344923
122PINK10.43138972
123PAK20.43102319
124MINK10.42659615
125BRD40.41514808
126RIPK40.40488121
127TGFBR10.39727052
128PRKD20.39092039
129MAP3K50.39061745
130FYN0.37273308
131NTRK10.36995989
132STK110.36876764
133IRAK20.36864498
134CDK11A0.36857168
135RPS6KA40.36825359
136CDK140.36508504
137CDK40.34255869

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.68318059
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.19493001
3Other glycan degradation_Homo sapiens_hsa005113.02594836
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72425105
5Primary bile acid biosynthesis_Homo sapiens_hsa001201.90923136
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88521452
7Arginine biosynthesis_Homo sapiens_hsa002201.84072142
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66024374
9Fatty acid degradation_Homo sapiens_hsa000711.60523990
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59990646
11Fructose and mannose metabolism_Homo sapiens_hsa000511.56732320
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45743407
13Insulin resistance_Homo sapiens_hsa049311.40792169
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39030255
15Bile secretion_Homo sapiens_hsa049761.35293455
16Shigellosis_Homo sapiens_hsa051311.31790318
17Bladder cancer_Homo sapiens_hsa052191.29703090
18Notch signaling pathway_Homo sapiens_hsa043301.29259741
19Fatty acid metabolism_Homo sapiens_hsa012121.28942344
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.28519292
21PPAR signaling pathway_Homo sapiens_hsa033201.26048412
22Type II diabetes mellitus_Homo sapiens_hsa049301.24626709
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21193296
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19463062
25B cell receptor signaling pathway_Homo sapiens_hsa046621.16519480
26Galactose metabolism_Homo sapiens_hsa000521.15275611
27Tryptophan metabolism_Homo sapiens_hsa003801.12630485
28Staphylococcus aureus infection_Homo sapiens_hsa051501.12546885
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12435959
30mTOR signaling pathway_Homo sapiens_hsa041501.12424992
31Salmonella infection_Homo sapiens_hsa051321.11219791
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11101622
33Chronic myeloid leukemia_Homo sapiens_hsa052201.09134132
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08625975
35VEGF signaling pathway_Homo sapiens_hsa043701.06769131
36Hepatitis B_Homo sapiens_hsa051611.06610417
37Vibrio cholerae infection_Homo sapiens_hsa051101.05890310
38Osteoclast differentiation_Homo sapiens_hsa043801.04779793
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04515228
40Complement and coagulation cascades_Homo sapiens_hsa046101.01656195
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.00817092
42Lysine degradation_Homo sapiens_hsa003101.00628677
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99209868
44Caffeine metabolism_Homo sapiens_hsa002320.98595980
45Hepatitis C_Homo sapiens_hsa051600.98345936
46Adherens junction_Homo sapiens_hsa045200.97726104
47ErbB signaling pathway_Homo sapiens_hsa040120.97219660
48Insulin signaling pathway_Homo sapiens_hsa049100.96951669
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95541272
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95034101
51Propanoate metabolism_Homo sapiens_hsa006400.94316637
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94123565
53Non-small cell lung cancer_Homo sapiens_hsa052230.93637518
54Acute myeloid leukemia_Homo sapiens_hsa052210.93186068
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93184023
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93174269
57Biosynthesis of amino acids_Homo sapiens_hsa012300.92573366
58Small cell lung cancer_Homo sapiens_hsa052220.91854964
59T cell receptor signaling pathway_Homo sapiens_hsa046600.91834123
60TNF signaling pathway_Homo sapiens_hsa046680.91525254
61Lysosome_Homo sapiens_hsa041420.91501330
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91261959
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91006407
64Inositol phosphate metabolism_Homo sapiens_hsa005620.90421323
65HIF-1 signaling pathway_Homo sapiens_hsa040660.89901129
66Thyroid cancer_Homo sapiens_hsa052160.89579859
67Pertussis_Homo sapiens_hsa051330.88936855
68AMPK signaling pathway_Homo sapiens_hsa041520.88098557
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.87695245
70Carbon metabolism_Homo sapiens_hsa012000.86473459
71Influenza A_Homo sapiens_hsa051640.86267357
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85787448
73Primary immunodeficiency_Homo sapiens_hsa053400.84320759
74Apoptosis_Homo sapiens_hsa042100.84109879
75Glycerolipid metabolism_Homo sapiens_hsa005610.83040413
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82596552
77Tuberculosis_Homo sapiens_hsa051520.82443928
78Leishmaniasis_Homo sapiens_hsa051400.81992435
79Butanoate metabolism_Homo sapiens_hsa006500.81476922
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80426336
81Glioma_Homo sapiens_hsa052140.79542361
82Glucagon signaling pathway_Homo sapiens_hsa049220.78957198
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78766838
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78646396
85Phagosome_Homo sapiens_hsa041450.78390017
86Choline metabolism in cancer_Homo sapiens_hsa052310.77861063
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.77728729
88Pancreatic cancer_Homo sapiens_hsa052120.77702492
89ABC transporters_Homo sapiens_hsa020100.77316481
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76644603
91Prion diseases_Homo sapiens_hsa050200.76523478
92Prolactin signaling pathway_Homo sapiens_hsa049170.75960508
93Platelet activation_Homo sapiens_hsa046110.74720300
94Endocytosis_Homo sapiens_hsa041440.73095553
95Estrogen signaling pathway_Homo sapiens_hsa049150.72993389
96Selenocompound metabolism_Homo sapiens_hsa004500.72383737
97ECM-receptor interaction_Homo sapiens_hsa045120.71420684
98Pyruvate metabolism_Homo sapiens_hsa006200.71233664
99Toxoplasmosis_Homo sapiens_hsa051450.70001103
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.69804384
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69795228
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69251125
103Endometrial cancer_Homo sapiens_hsa052130.69188499
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.68575900
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67835059
106Amoebiasis_Homo sapiens_hsa051460.67393019
107Viral carcinogenesis_Homo sapiens_hsa052030.67349607
108Malaria_Homo sapiens_hsa051440.67342909
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67330156
110Dorso-ventral axis formation_Homo sapiens_hsa043200.66792619
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65765606
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65724425
113Fat digestion and absorption_Homo sapiens_hsa049750.65444617
114Measles_Homo sapiens_hsa051620.65088374
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64648542
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64096730
117Gastric acid secretion_Homo sapiens_hsa049710.63461581
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.61502827
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60696465
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.60473397
121Prostate cancer_Homo sapiens_hsa052150.60155089
122MicroRNAs in cancer_Homo sapiens_hsa052060.60021006
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.59898990
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59399198
125Insulin secretion_Homo sapiens_hsa049110.58759099
126Renal cell carcinoma_Homo sapiens_hsa052110.58535231
127Legionellosis_Homo sapiens_hsa051340.58046297
128Proteoglycans in cancer_Homo sapiens_hsa052050.57682582
129Fatty acid biosynthesis_Homo sapiens_hsa000610.56852143
130beta-Alanine metabolism_Homo sapiens_hsa004100.55685447
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55166921
132Pentose phosphate pathway_Homo sapiens_hsa000300.54154999
133Chemokine signaling pathway_Homo sapiens_hsa040620.54144503
134Focal adhesion_Homo sapiens_hsa045100.53343249
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53158243
136Pancreatic secretion_Homo sapiens_hsa049720.51298193
137Viral myocarditis_Homo sapiens_hsa054160.49021898
138Colorectal cancer_Homo sapiens_hsa052100.48935654
139GnRH signaling pathway_Homo sapiens_hsa049120.48004109
140Starch and sucrose metabolism_Homo sapiens_hsa005000.47995932
141Long-term potentiation_Homo sapiens_hsa047200.45214855
142Synaptic vesicle cycle_Homo sapiens_hsa047210.44764683

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