TRPC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.80450921
2vocalization behavior (GO:0071625)5.71870006
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.42077523
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.41944781
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27366611
6presynaptic membrane assembly (GO:0097105)5.20928239
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18949549
8protein localization to synapse (GO:0035418)4.99302054
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.97832553
10glutamate receptor signaling pathway (GO:0007215)4.87077823
11regulation of glutamate receptor signaling pathway (GO:1900449)4.84312714
12synaptic transmission, glutamatergic (GO:0035249)4.78155616
13paraxial mesoderm development (GO:0048339)4.72444755
14postsynaptic membrane organization (GO:0001941)4.50859390
15presynaptic membrane organization (GO:0097090)4.50753768
16neuron-neuron synaptic transmission (GO:0007270)4.47926704
17positive regulation of synapse maturation (GO:0090129)4.43921924
18synaptic vesicle exocytosis (GO:0016079)4.37576371
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.31259069
20neuron recognition (GO:0008038)4.25208694
21neurotransmitter-gated ion channel clustering (GO:0072578)4.24728387
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.23824641
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.09702455
24regulation of synaptic vesicle exocytosis (GO:2000300)4.02058722
25regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93551145
26startle response (GO:0001964)3.88569461
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.88345517
28glutamate secretion (GO:0014047)3.84889527
29regulation of synapse maturation (GO:0090128)3.84591979
30exploration behavior (GO:0035640)3.78948611
31locomotory exploration behavior (GO:0035641)3.76953252
32regulation of postsynaptic membrane potential (GO:0060078)3.76054692
33regulation of synaptic vesicle transport (GO:1902803)3.75767711
34axonal fasciculation (GO:0007413)3.74998221
35regulation of female receptivity (GO:0045924)3.72842466
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72742205
37regulation of neuronal synaptic plasticity (GO:0048168)3.70201061
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.68550469
39female mating behavior (GO:0060180)3.68060875
40central nervous system projection neuron axonogenesis (GO:0021952)3.64902380
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.61526473
42collagen fibril organization (GO:0030199)3.61049891
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.60657085
44long-term memory (GO:0007616)3.57177725
45neuronal action potential propagation (GO:0019227)3.57133039
46synaptic vesicle endocytosis (GO:0048488)3.56739738
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56227916
48behavioral defense response (GO:0002209)3.55110163
49behavioral fear response (GO:0001662)3.55110163
50serotonin receptor signaling pathway (GO:0007210)3.54600017
51synapse assembly (GO:0007416)3.53818766
52long-term synaptic potentiation (GO:0060291)3.52074226
53proline transport (GO:0015824)3.47193510
54chondrocyte proliferation (GO:0035988)3.45801557
55regulation of synaptic plasticity (GO:0048167)3.44538510
56regulation of dendritic spine morphogenesis (GO:0061001)3.43844095
57negative regulation of axon extension involved in axon guidance (GO:0048843)3.43344573
58positive regulation of membrane potential (GO:0045838)3.42204575
59transmission of nerve impulse (GO:0019226)3.37806422
60sequestering of extracellular ligand from receptor (GO:0035581)3.33668521
61response to histamine (GO:0034776)3.33563036
62neurotransmitter secretion (GO:0007269)3.33401249
63regulation of synapse structural plasticity (GO:0051823)3.32193030
64fear response (GO:0042596)3.30358912
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.28429867
66innervation (GO:0060384)3.27815650
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.27799480
68dendrite development (GO:0016358)3.21369517
69negative regulation of axon guidance (GO:1902668)3.20160162
70regulation of respiratory system process (GO:0044065)3.19421958
71learning (GO:0007612)3.17639856
72positive regulation of synapse assembly (GO:0051965)3.16957888
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16677626
74positive regulation of neurotransmitter secretion (GO:0001956)3.14590593
75detection of calcium ion (GO:0005513)3.13524829
76membrane depolarization (GO:0051899)3.11259447
77regulation of dendritic spine development (GO:0060998)3.10649606
78synaptic vesicle maturation (GO:0016188)3.10262841
79regulation of glutamate secretion (GO:0014048)3.08806414
80metaphase plate congression (GO:0051310)3.06355309
81long term synaptic depression (GO:0060292)3.03467626
82central nervous system neuron axonogenesis (GO:0021955)3.03223244
83cell migration involved in sprouting angiogenesis (GO:0002042)3.01961843
84anterior/posterior axis specification, embryo (GO:0008595)3.01450679
85regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.01361243
86regulation of neurotransmitter secretion (GO:0046928)3.01095368
87outer ear morphogenesis (GO:0042473)3.01027430
88cochlea development (GO:0090102)3.00558261
89regulation of vesicle fusion (GO:0031338)2.99761237
90membrane depolarization during action potential (GO:0086010)2.97824234
91synaptic transmission (GO:0007268)2.97611737
92regulation of synaptic transmission, GABAergic (GO:0032228)2.96685499
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96656052
94regulation of synapse assembly (GO:0051963)2.96448709
95membrane hyperpolarization (GO:0060081)2.95993125
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95853296
97negative regulation of activin receptor signaling pathway (GO:0032926)2.95289855
98mesenchymal-epithelial cell signaling (GO:0060638)2.94328032
99dendritic spine morphogenesis (GO:0060997)2.93805397
100behavioral response to cocaine (GO:0048148)2.90493243
101mitotic metaphase plate congression (GO:0007080)2.90401285
102regulation of synapse organization (GO:0050807)2.89850425
103neurotransmitter transport (GO:0006836)2.89774329
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89739142
105establishment of integrated proviral latency (GO:0075713)2.89100541
106associative learning (GO:0008306)2.87669233
107positive regulation of dendritic spine development (GO:0060999)2.87258925
108pyrimidine nucleobase catabolic process (GO:0006208)2.86830969
109behavioral response to ethanol (GO:0048149)2.85658268
110regulation of cell fate specification (GO:0042659)2.84747514
111protein heterotrimerization (GO:0070208)2.84628695
112inner ear receptor cell development (GO:0060119)2.84548760
113regulation of synaptic transmission (GO:0050804)2.83180512
114synapse organization (GO:0050808)2.82719909
115dendrite morphogenesis (GO:0048813)2.81813160
116social behavior (GO:0035176)2.81585337
117intraspecies interaction between organisms (GO:0051703)2.81585337
118axon extension involved in axon guidance (GO:0048846)2.78169894
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.78169894
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.76714945
121ventricular cardiac muscle cell development (GO:0055015)2.71574095
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70576287
123lymphangiogenesis (GO:0001946)2.65555456
124artery development (GO:0060840)2.64113740
125negative chemotaxis (GO:0050919)2.62040760
126somite rostral/caudal axis specification (GO:0032525)2.61631837
127lung-associated mesenchyme development (GO:0060484)2.60460455
128regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.59703103
129regulation of mesoderm development (GO:2000380)2.56676149
130positive regulation of cardiac muscle cell proliferation (GO:0060045)2.55970476
131positive regulation of cardiac muscle tissue development (GO:0055025)2.55129074
132endodermal cell differentiation (GO:0035987)2.53212644
133lateral sprouting from an epithelium (GO:0060601)2.52715240
134establishment of chromosome localization (GO:0051303)2.48576321
135activin receptor signaling pathway (GO:0032924)2.48194711
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47072118
137regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.46954571
138female gonad development (GO:0008585)2.45335982
139cell adhesion mediated by integrin (GO:0033627)2.44927127
140positive regulation of cardiac muscle tissue growth (GO:0055023)2.44893069
141regulation of gene silencing by RNA (GO:0060966)2.43985208
142regulation of posttranscriptional gene silencing (GO:0060147)2.43985208
143regulation of gene silencing by miRNA (GO:0060964)2.43985208
144bone trabecula formation (GO:0060346)2.43679072
145regulation of gastrulation (GO:0010470)2.39926790
146establishment of viral latency (GO:0019043)2.39199514
147nodal signaling pathway (GO:0038092)2.38591489
148G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.38203754
149olfactory bulb development (GO:0021772)2.38076514
150regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36030595
151primitive streak formation (GO:0090009)2.35568222
152anterior/posterior axis specification (GO:0009948)2.34774410
153dorsal/ventral axis specification (GO:0009950)2.33702356
154growth hormone secretion (GO:0030252)2.33153848
155embryonic foregut morphogenesis (GO:0048617)2.32573270
156regulation of axon extension involved in axon guidance (GO:0048841)2.31491646
157negative regulation of chondrocyte differentiation (GO:0032331)2.31234850
158chromatin remodeling at centromere (GO:0031055)2.29871225
159heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.29799593
160regulation of axon guidance (GO:1902667)2.29649136
161CENP-A containing nucleosome assembly (GO:0034080)2.29106673
162substrate-dependent cell migration (GO:0006929)2.28644186
163positive regulation of catecholamine secretion (GO:0033605)2.25676240
164kinetochore organization (GO:0051383)2.24981777
165negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.24214219
166kidney mesenchyme development (GO:0072074)2.23278129
167substrate adhesion-dependent cell spreading (GO:0034446)2.22889196
168convergent extension (GO:0060026)2.21024991
169organ induction (GO:0001759)2.20308613
170neural crest cell development (GO:0014032)2.19608116
171notochord development (GO:0030903)2.19492028
172endothelial cell morphogenesis (GO:0001886)2.18464321
173cell fate commitment involved in formation of primary germ layer (GO:0060795)2.16796283
174kinetochore assembly (GO:0051382)2.16764320
175positive regulation of heart growth (GO:0060421)2.15931760
176regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.13513344
177positive regulation of protein autophosphorylation (GO:0031954)2.12156963
178chaperone-mediated protein transport (GO:0072321)2.11328974
179regulation of development, heterochronic (GO:0040034)2.09970051
180regulation of mitotic spindle checkpoint (GO:1903504)2.09657757
181regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.09657757
182glomerulus development (GO:0032835)2.09544356
183regulation of organ formation (GO:0003156)2.08918192
184regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.08830289
185protein localization to kinetochore (GO:0034501)2.08101332
186regulation of cardiac muscle tissue development (GO:0055024)2.07721299
187cellular response to BMP stimulus (GO:0071773)2.07309671
188response to BMP (GO:0071772)2.07309671
189dermatan sulfate biosynthetic process (GO:0030208)2.06989636
190nucleobase catabolic process (GO:0046113)2.06602131
191negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.06145923
192negative regulation of mitotic sister chromatid segregation (GO:0033048)2.06145923
193negative regulation of sister chromatid segregation (GO:0033046)2.06145923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47658466
2GBX2_23144817_ChIP-Seq_PC3_Human4.36412503
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.29830159
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94957890
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89642247
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78231349
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.76093305
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53527081
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.44417277
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.43512184
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42596373
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42596373
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39392927
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39001819
15REST_21632747_ChIP-Seq_MESCs_Mouse2.33723913
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33556365
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.31361542
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28857326
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18338074
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16153500
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13795228
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12929470
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12557626
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11851120
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.08609321
26TAF15_26573619_Chip-Seq_HEK293_Human2.04720655
27* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00386337
28EWS_26573619_Chip-Seq_HEK293_Human1.99399242
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.99361104
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.99060137
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97431937
32DROSHA_22980978_ChIP-Seq_HELA_Human1.96444309
33IGF1R_20145208_ChIP-Seq_DFB_Human1.96402823
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94494679
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93426867
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89811806
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89759319
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87262142
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.84415343
40P300_19829295_ChIP-Seq_ESCs_Human1.83954277
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83754301
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.83610507
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.78240326
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.77017838
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76979910
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75372145
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71670624
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68645850
49FUS_26573619_Chip-Seq_HEK293_Human1.66918868
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65526446
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.63986728
52ELK1_19687146_ChIP-ChIP_HELA_Human1.63465104
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62807903
54* BRD4_25478319_ChIP-Seq_HGPS_Human1.61906647
55VDR_22108803_ChIP-Seq_LS180_Human1.60289787
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.60244666
57ZNF274_21170338_ChIP-Seq_K562_Hela1.57996148
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55644914
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54503863
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53262316
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.51249864
62TBX3_20139965_ChIP-Seq_MESCs_Mouse1.50469114
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50234705
64* SMAD_19615063_ChIP-ChIP_OVARY_Human1.49674015
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47915969
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.47874337
67* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46435162
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.46136039
69* AR_25329375_ChIP-Seq_VCAP_Human1.43674346
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42587693
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41229824
72AR_21572438_ChIP-Seq_LNCaP_Human1.39358984
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.36794965
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36440479
75* STAT3_23295773_ChIP-Seq_U87_Human1.35927421
76RNF2_27304074_Chip-Seq_NSC_Mouse1.34253403
77TP53_18474530_ChIP-ChIP_U2OS_Human1.33394381
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33130960
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30994138
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29998968
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27175985
82TCF4_23295773_ChIP-Seq_U87_Human1.27111502
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27097942
84* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27034766
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.26936932
86* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26504095
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26204570
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.25718225
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25146247
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25146247
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.25085950
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24483359
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23899781
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.23162003
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23019445
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23019445
97* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21832152
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21586880
99ER_23166858_ChIP-Seq_MCF-7_Human1.20967834
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19912316
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19748281
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19602933
103CJUN_26792858_Chip-Seq_BT549_Human1.19201562
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18871959
105* SOX9_26525672_Chip-Seq_HEART_Mouse1.17157442
106AHR_22903824_ChIP-Seq_MCF-7_Human1.15965732
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13935385
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.13849577
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13807556
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13305001
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.12952748
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12763526
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12232250
114AR_19668381_ChIP-Seq_PC3_Human1.12143722
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11842324
116CBP_20019798_ChIP-Seq_JUKART_Human1.11665952
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11665952
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.10721485
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.09791685
120* E2F1_18555785_Chip-Seq_ESCs_Mouse1.09656961
121* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09431124
122RING1B_27294783_Chip-Seq_ESCs_Mouse1.09006184
123P53_22387025_ChIP-Seq_ESCs_Mouse1.08889264
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.08624571
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08187086
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07663589
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06164819
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05970458
129JUN_21703547_ChIP-Seq_K562_Human1.05762543
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04565874
131BCAT_22108803_ChIP-Seq_LS180_Human1.04290662
132RING1B_27294783_Chip-Seq_NPCs_Mouse1.03575547
133IRF1_19129219_ChIP-ChIP_H3396_Human1.03019494
134SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02940943
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02828316
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.02546091
137PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02346249
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02280904
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00951476
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00738533
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.00211940
142CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99990971
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99868292
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99592839
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99403252
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99336248
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99052713
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.99042684
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99004069
150AR_21909140_ChIP-Seq_LNCAP_Human0.98755263
151KDM2B_26808549_Chip-Seq_REH_Human0.98207826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49206432
2MP0003880_abnormal_central_pattern5.12751645
3MP0008438_abnormal_cutaneous_collagen4.56478232
4MP0003635_abnormal_synaptic_transmissio3.72539294
5MP0009745_abnormal_behavioral_response3.28036508
6MP0002063_abnormal_learning/memory/cond3.23844807
7MP0003787_abnormal_imprinting3.03521700
8MP0004270_analgesia3.02339760
9MP0001968_abnormal_touch/_nociception3.00470645
10MP0002736_abnormal_nociception_after2.91539107
11MP0002064_seizures2.85793799
12MP0002735_abnormal_chemical_nociception2.85627982
13MP0009384_cardiac_valve_regurgitation2.85085149
14MP0010030_abnormal_orbit_morphology2.74246208
15MP0002572_abnormal_emotion/affect_behav2.72587538
16MP0005423_abnormal_somatic_nervous2.57244696
17MP0001501_abnormal_sleep_pattern2.53001503
18MP0004272_abnormal_basement_membrane2.52918637
19MP0005503_abnormal_tendon_morphology2.51057639
20MP0002272_abnormal_nervous_system2.45551088
21MP0001299_abnormal_eye_distance/2.38585156
22MP0009046_muscle_twitch2.38161994
23MP0005275_abnormal_skin_tensile2.31743670
24MP0005623_abnormal_meninges_morphology2.29323588
25MP0005646_abnormal_pituitary_gland2.27010383
26MP0002734_abnormal_mechanical_nocicepti2.25648022
27MP0003890_abnormal_embryonic-extraembry2.25523914
28MP0000778_abnormal_nervous_system2.22823096
29MP0006054_spinal_hemorrhage2.20458077
30MP0001188_hyperpigmentation2.18558551
31MP0001486_abnormal_startle_reflex2.17877203
32MP0006276_abnormal_autonomic_nervous2.17327006
33MP0003941_abnormal_skin_development2.17256316
34MP0001440_abnormal_grooming_behavior2.14031584
35MP0001984_abnormal_olfaction2.07631430
36MP0000049_abnormal_middle_ear2.02856065
37MP0002184_abnormal_innervation2.02468762
38MP0005645_abnormal_hypothalamus_physiol1.96560792
39MP0002067_abnormal_sensory_capabilities1.94969839
40MP0006292_abnormal_olfactory_placode1.93573186
41MP0001529_abnormal_vocalization1.91277409
42MP0003937_abnormal_limbs/digits/tail_de1.89140944
43MP0002822_catalepsy1.86961040
44MP0001293_anophthalmia1.82409754
45MP0003279_aneurysm1.76750499
46MP0002557_abnormal_social/conspecific_i1.75953042
47MP0002938_white_spotting1.73696846
48MP0003385_abnormal_body_wall1.73240570
49MP0002876_abnormal_thyroid_physiology1.73158037
50MP0005394_taste/olfaction_phenotype1.70144198
51MP0005499_abnormal_olfactory_system1.70144198
52MP0003755_abnormal_palate_morphology1.69899919
53MP0001958_emphysema1.66926444
54MP0003283_abnormal_digestive_organ1.66863442
55MP0001970_abnormal_pain_threshold1.65967288
56MP0003705_abnormal_hypodermis_morpholog1.63447143
57MP0010386_abnormal_urinary_bladder1.61730058
58MP0002733_abnormal_thermal_nociception1.60590628
59MP0002233_abnormal_nose_morphology1.59492818
60MP0004924_abnormal_behavior1.57406036
61MP0005386_behavior/neurological_phenoty1.57406036
62MP0005187_abnormal_penis_morphology1.52179582
63MP0005257_abnormal_intraocular_pressure1.50408362
64MP0004811_abnormal_neuron_physiology1.48256863
65MP0010368_abnormal_lymphatic_system1.45775080
66MP0002909_abnormal_adrenal_gland1.44451306
67MP0009250_abnormal_appendicular_skeleto1.44095710
68MP0002837_dystrophic_cardiac_calcinosis1.43706835
69MP0003879_abnormal_hair_cell1.37427419
70MP0001542_abnormal_bone_strength1.36935189
71MP0003942_abnormal_urinary_system1.36908367
72MP0000462_abnormal_digestive_system1.35985126
73MP0000955_abnormal_spinal_cord1.34480751
74MP0002882_abnormal_neuron_morphology1.33654213
75MP0002254_reproductive_system_inflammat1.33377035
76MP0000428_abnormal_craniofacial_morphol1.33236106
77MP0001986_abnormal_taste_sensitivity1.32966999
78MP0008569_lethality_at_weaning1.32562089
79MP0009780_abnormal_chondrocyte_physiolo1.31887226
80MP0002697_abnormal_eye_size1.28602325
81MP0005551_abnormal_eye_electrophysiolog1.26528096
82MP0003119_abnormal_digestive_system1.26397370
83MP0005171_absent_coat_pigmentation1.25070180
84MP0004858_abnormal_nervous_system1.22738097
85MP0001286_abnormal_eye_development1.21833591
86MP0010352_gastrointestinal_tract_polyps1.21797854
87MP0003935_abnormal_craniofacial_develop1.21676118
88MP0002066_abnormal_motor_capabilities/c1.19776918
89MP0005508_abnormal_skeleton_morphology1.17347827
90MP0002295_abnormal_pulmonary_circulatio1.14959917
91MP0000534_abnormal_ureter_morphology1.14614590
92MP0003566_abnormal_cell_adhesion1.13987737
93MP0001905_abnormal_dopamine_level1.13755445
94MP0008789_abnormal_olfactory_epithelium1.13492430
95MP0002152_abnormal_brain_morphology1.11789122
96MP0008932_abnormal_embryonic_tissue1.11643088
97MP0000013_abnormal_adipose_tissue1.11496314
98MP0000762_abnormal_tongue_morphology1.11329661
99MP0003329_amyloid_beta_deposits1.11253573
100MP0003950_abnormal_plasma_membrane1.09492670
101MP0004142_abnormal_muscle_tone1.08489220
102MP0000631_abnormal_neuroendocrine_gland1.07340191
103MP0004484_altered_response_of1.06591595
104MP0002084_abnormal_developmental_patter1.06264326
105MP0000432_abnormal_head_morphology1.04790620
106MP0004085_abnormal_heartbeat1.04420154
107MP0009053_abnormal_anal_canal1.02397957
108MP0004215_abnormal_myocardial_fiber1.02272644
109MP0008877_abnormal_DNA_methylation0.99775290
110MP0004134_abnormal_chest_morphology0.99708350
111MP0002069_abnormal_eating/drinking_beha0.99697050
112MP0001177_atelectasis0.99331640
113MP0000767_abnormal_smooth_muscle0.98321792
114MP0004885_abnormal_endolymph0.97493898
115MP0002116_abnormal_craniofacial_bone0.97465235
116MP0002111_abnormal_tail_morphology0.95021040
117MP0002085_abnormal_embryonic_tissue0.94675799
118MP0001502_abnormal_circadian_rhythm0.93283168
119MP0003122_maternal_imprinting0.93232595
120MP0001963_abnormal_hearing_physiology0.92510241
121MP0008058_abnormal_DNA_repair0.92486353
122MP0002282_abnormal_trachea_morphology0.92325099
123MP0003121_genomic_imprinting0.92302969
124MP0003633_abnormal_nervous_system0.91930086
125MP0005248_abnormal_Harderian_gland0.91839262
126MP0002092_abnormal_eye_morphology0.91598298
127MP0001879_abnormal_lymphatic_vessel0.90680270
128MP0002932_abnormal_joint_morphology0.90644606
129MP0002752_abnormal_somatic_nervous0.89016787
130MP0002102_abnormal_ear_morphology0.85391870
131MP0003567_abnormal_fetal_cardiomyocyte0.83362595
132MP0000026_abnormal_inner_ear0.82821953
133MP0002108_abnormal_muscle_morphology0.82241329
134MP0003631_nervous_system_phenotype0.81845783
135MP0005620_abnormal_muscle_contractility0.80945711
136MP0003137_abnormal_impulse_conducting0.79834508
137MP0005391_vision/eye_phenotype0.79440317
138MP0009703_decreased_birth_body0.79136325
139* MP0005595_abnormal_vascular_smooth0.78220530
140MP0002229_neurodegeneration0.77913997
141MP0002638_abnormal_pupillary_reflex0.76978082
142MP0000569_abnormal_digit_pigmentation0.76841861
143MP0002109_abnormal_limb_morphology0.76736834
144MP0002114_abnormal_axial_skeleton0.75073314
145MP0004197_abnormal_fetal_growth/weight/0.74156976
146MP0002081_perinatal_lethality0.73727503
147MP0005084_abnormal_gallbladder_morpholo0.72707137
148MP0000163_abnormal_cartilage_morphology0.72196939
149MP0003861_abnormal_nervous_system0.71412093
150MP0003718_maternal_effect0.71122529
151MP0000749_muscle_degeneration0.70932359
152MP0005409_darkened_coat_color0.70868314
153MP0001664_abnormal_digestion0.69930598
154MP0000681_abnormal_thyroid_gland0.69421808
155MP0000015_abnormal_ear_pigmentation0.68751267
156MP0003136_yellow_coat_color0.68653322
157MP0001485_abnormal_pinna_reflex0.67631418
158MP0002751_abnormal_autonomic_nervous0.66953820
159MP0003938_abnormal_ear_development0.65490494
160MP0004742_abnormal_vestibular_system0.65125855
161MP0008874_decreased_physiological_sensi0.64700102
162MP0002234_abnormal_pharynx_morphology0.64548173
163MP0004145_abnormal_muscle_electrophysio0.62128375
164MP0008872_abnormal_physiological_respon0.58469846
165MP0000751_myopathy0.54789128
166MP0004133_heterotaxia0.54008950
167MP0000678_abnormal_parathyroid_gland0.52859572
168MP0006072_abnormal_retinal_apoptosis0.52573738
169MP0001943_abnormal_respiration0.51579178
170MP0003632_abnormal_nervous_system0.51180302
171MP0010770_preweaning_lethality0.51125117
172MP0002082_postnatal_lethality0.51125117
173MP0010769_abnormal_survival0.48905478

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.02015875
2Febrile seizures (HP:0002373)5.66118203
3Epileptic encephalopathy (HP:0200134)5.54083180
4Premature rupture of membranes (HP:0001788)5.20109360
5Hyperventilation (HP:0002883)5.08717332
6Atonic seizures (HP:0010819)4.94658788
7Focal seizures (HP:0007359)4.87062498
8Myokymia (HP:0002411)4.14541976
9Absence seizures (HP:0002121)4.04292841
10Visual hallucinations (HP:0002367)3.98538424
11Aortic dissection (HP:0002647)3.95354533
12Dialeptic seizures (HP:0011146)3.79361317
13Progressive cerebellar ataxia (HP:0002073)3.71403757
14Amblyopia (HP:0000646)3.59474746
15Generalized tonic-clonic seizures (HP:0002069)3.58198201
16Protruding tongue (HP:0010808)3.58046397
17Soft skin (HP:0000977)3.56647198
18Broad-based gait (HP:0002136)3.45673900
19Aortic aneurysm (HP:0004942)3.41915027
20Protrusio acetabuli (HP:0003179)3.31724965
21Septo-optic dysplasia (HP:0100842)3.24431184
22Abdominal situs inversus (HP:0003363)3.23013596
23Abnormality of abdominal situs (HP:0011620)3.23013596
24Abnormality of dentin (HP:0010299)3.19658966
25Broad metatarsal (HP:0001783)3.15839510
26Coronal craniosynostosis (HP:0004440)3.14725890
27Epileptiform EEG discharges (HP:0011182)3.14033304
28Excessive salivation (HP:0003781)3.10044358
29Drooling (HP:0002307)3.10044358
30Thyroid-stimulating hormone excess (HP:0002925)3.05998362
31Fibular aplasia (HP:0002990)3.00838118
32Gaze-evoked nystagmus (HP:0000640)2.92680544
33Asymmetry of the thorax (HP:0001555)2.91413254
34Poor eye contact (HP:0000817)2.88408250
35Follicular hyperkeratosis (HP:0007502)2.86617244
36Bifid tongue (HP:0010297)2.84018996
37Short tibia (HP:0005736)2.81547919
38Absent speech (HP:0001344)2.78776440
39EEG with generalized epileptiform discharges (HP:0011198)2.74324347
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.70643149
41Decreased circulating renin level (HP:0003351)2.60897758
42Ankle contracture (HP:0006466)2.60052108
43Fair hair (HP:0002286)2.58925660
44Cortical dysplasia (HP:0002539)2.56311381
45Hypsarrhythmia (HP:0002521)2.51113426
46Intestinal atresia (HP:0011100)2.50412439
47Genu recurvatum (HP:0002816)2.47255352
48Shallow orbits (HP:0000586)2.46997648
49Impaired social interactions (HP:0000735)2.44860391
50Abnormal social behavior (HP:0012433)2.44860391
51Gastroesophageal reflux (HP:0002020)2.44275264
52Medial flaring of the eyebrow (HP:0010747)2.42232067
53Gait imbalance (HP:0002141)2.42073292
54Generalized hypopigmentation of hair (HP:0011358)2.37211238
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36585511
56Inability to walk (HP:0002540)2.35732869
57Bladder diverticulum (HP:0000015)2.28734677
58Morphological abnormality of the middle ear (HP:0008609)2.27676015
59Neonatal short-limb short stature (HP:0008921)2.26591603
60Truncal ataxia (HP:0002078)2.26369811
61Colon cancer (HP:0003003)2.24410313
62Diplopia (HP:0000651)2.24304492
63Abnormality of binocular vision (HP:0011514)2.24304492
64Thickened helices (HP:0000391)2.24137995
65Preaxial foot polydactyly (HP:0001841)2.24106776
66Fetal akinesia sequence (HP:0001989)2.22858763
67Palpebral edema (HP:0100540)2.22567840
68Blue irides (HP:0000635)2.22374678
69Bowel diverticulosis (HP:0005222)2.22018582
70Delayed gross motor development (HP:0002194)2.20518537
71Exotropia (HP:0000577)2.18136427
72Abnormal eating behavior (HP:0100738)2.17552040
73Abnormality of the lower motor neuron (HP:0002366)2.17214717
74Abnormality of salivation (HP:0100755)2.15146467
75Impaired vibration sensation in the lower limbs (HP:0002166)2.14433854
76Congenital primary aphakia (HP:0007707)2.13483432
77Mesomelia (HP:0003027)2.13426805
78Myelomeningocele (HP:0002475)2.12028288
79Retinal dysplasia (HP:0007973)2.08268723
80Depression (HP:0000716)2.07910646
81Vascular tortuosity (HP:0004948)2.07617049
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07421502
83Nephrogenic diabetes insipidus (HP:0009806)2.05804794
84Hyperthyroidism (HP:0000836)2.04122190
85Hypoventilation (HP:0002791)2.03445294
86Progressive inability to walk (HP:0002505)2.03339953
87Widely spaced teeth (HP:0000687)2.02893459
88Atrophic scars (HP:0001075)2.02659709
89Dysmetria (HP:0001310)2.02408199
90Anophthalmia (HP:0000528)2.01767682
91Abnormal hair whorl (HP:0010721)1.98933661
92Polyphagia (HP:0002591)1.98021839
93Aortic regurgitation (HP:0001659)1.97719029
94Genital tract atresia (HP:0001827)1.94991757
95Optic nerve hypoplasia (HP:0000609)1.94884213
96Aqueductal stenosis (HP:0002410)1.94642318
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94186153
98Hypoplasia of the brainstem (HP:0002365)1.94186153
99Abnormality of the labia minora (HP:0012880)1.92770711
100Hemiparesis (HP:0001269)1.91993995
101Dysdiadochokinesis (HP:0002075)1.91989346
102Absent septum pellucidum (HP:0001331)1.90546398
103Anxiety (HP:0000739)1.88089706
104Spastic diplegia (HP:0001264)1.87879389
105Broad long bones (HP:0005622)1.87784132
106Hepatoblastoma (HP:0002884)1.87701361
107Arterial tortuosity (HP:0005116)1.86279375
108Impaired smooth pursuit (HP:0007772)1.83448469
109Cerebral inclusion bodies (HP:0100314)1.83013338
110Bilateral microphthalmos (HP:0007633)1.82490101
111Dynein arm defect of respiratory motile cilia (HP:0012255)1.82081597
112Absent/shortened dynein arms (HP:0200106)1.82081597
113Stereotypic behavior (HP:0000733)1.81563336
114Mitral valve prolapse (HP:0001634)1.80772250
115Supranuclear gaze palsy (HP:0000605)1.80361543
116Supernumerary spleens (HP:0009799)1.78838006
117Incomplete penetrance (HP:0003829)1.77960617
118Wide anterior fontanel (HP:0000260)1.77881952
119Oligodactyly (hands) (HP:0001180)1.77485378
120Infantile muscular hypotonia (HP:0008947)1.77151701
121Cutaneous finger syndactyly (HP:0010554)1.76196954
122Scanning speech (HP:0002168)1.75941401
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75866190
124Generalized myoclonic seizures (HP:0002123)1.75652463
125Esotropia (HP:0000565)1.75178085
126Omphalocele (HP:0001539)1.74311400
127Anosmia (HP:0000458)1.73502158
128Akinesia (HP:0002304)1.73366590
129Bradykinesia (HP:0002067)1.73358539
130Specific learning disability (HP:0001328)1.72396952
131Vaginal atresia (HP:0000148)1.72119783
132Abnormal ciliary motility (HP:0012262)1.71958498
133Severe Myopia (HP:0011003)1.71373664
134Abnormality of the septum pellucidum (HP:0007375)1.70951083
135Overgrowth (HP:0001548)1.70743005
136Narrow nasal bridge (HP:0000446)1.70637395
137Partial agenesis of the corpus callosum (HP:0001338)1.70549884
138Aplasia involving bones of the extremities (HP:0009825)1.69499783
139Aplasia involving bones of the upper limbs (HP:0009823)1.69499783
140Aplasia of the phalanges of the hand (HP:0009802)1.69499783
141Genetic anticipation (HP:0003743)1.69296195
142Bradycardia (HP:0001662)1.69022573
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.68931111
144Pancreatic fibrosis (HP:0100732)1.68917426
145Absent eyebrow (HP:0002223)1.68504533
146Abnormality of the middle phalanges of the toes (HP:0010183)1.67094125
147Fibular hypoplasia (HP:0003038)1.66445272
148Deep palmar crease (HP:0006191)1.66124489
149Aplasia/Hypoplasia of the hallux (HP:0008362)1.64550449
150Short hallux (HP:0010109)1.63746205
151Postaxial hand polydactyly (HP:0001162)1.63059479
152Action tremor (HP:0002345)1.62572226
153Sleep apnea (HP:0010535)1.62321006
154Decreased muscle mass (HP:0003199)1.61941034
155Pulmonic stenosis (HP:0001642)1.61252765
156Cortical visual impairment (HP:0100704)1.60443090
157Abnormal lung lobation (HP:0002101)1.59681636
158Hyperextensible skin (HP:0000974)1.57619468
159Type 1 muscle fiber predominance (HP:0003803)1.56807524
160Abnormal delivery (HP:0001787)1.56331657
161Abnormality of the antihelix (HP:0009738)1.55642346
162Wormian bones (HP:0002645)1.53828499
163Broad phalanx (HP:0006009)1.52906020
164Micropenis (HP:0000054)1.52089109
165Deformed tarsal bones (HP:0008119)1.51877513
166Renal duplication (HP:0000075)1.51508614
167Maternal diabetes (HP:0009800)1.51005348
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.50563439
169Abnormality of pain sensation (HP:0010832)1.49496968
170Impaired pain sensation (HP:0007328)1.49496968
171Vitreoretinal degeneration (HP:0000655)1.49182249
172Broad foot (HP:0001769)1.47907000
173Broad ribs (HP:0000885)1.46810149
174Gastrointestinal atresia (HP:0002589)1.46656427
175Aplasia/hypoplasia of the humerus (HP:0006507)1.46466400
176Calcaneovalgus deformity (HP:0001848)1.46043480
177Ectopia lentis (HP:0001083)1.45480992
178Dental crowding (HP:0000678)1.45009263
179Preaxial hand polydactyly (HP:0001177)1.44425680
180Renal hypoplasia (HP:0000089)1.44285437
181Abnormal umbilical cord blood vessels (HP:0011403)1.41856853
182Single umbilical artery (HP:0001195)1.41856853
183Abnormality of the fetal cardiovascular system (HP:0010948)1.41856853
184Meckel diverticulum (HP:0002245)1.41505346
185Increased number of teeth (HP:0011069)1.41190530
186Labial hypoplasia (HP:0000066)1.40605618
187Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.40461244
188Blue sclerae (HP:0000592)1.39888984
189Abnormality of the musculature of the pelvis (HP:0001469)1.39888949
190Abnormality of the hip-girdle musculature (HP:0001445)1.39888949
191Wrist flexion contracture (HP:0001239)1.39596236
192Short humerus (HP:0005792)1.37827799
193Slender build (HP:0001533)1.37005209
194Shoulder girdle muscle weakness (HP:0003547)1.36074762
195Short foot (HP:0001773)1.34844534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.97653736
2EPHA44.61784231
3CASK4.28982960
4MAP2K73.44269563
5MYLK3.22338081
6MAP3K42.89998353
7MARK12.78361840
8WNK32.48471125
9PRPF4B2.44007984
10BMPR22.36509207
11MINK12.25738853
12STK38L2.20539154
13PLK22.18960966
14BUB12.15273436
15LIMK12.03624132
16TNIK1.97274503
17MAP3K121.90642906
18NTRK21.87463219
19RIPK41.85954194
20DYRK21.83158583
21SRPK11.79145867
22ERBB31.71218544
23MKNK21.70538998
24MAP2K41.68083797
25AKT31.67090094
26PLK31.64446222
27PAK21.61763170
28SGK21.60991878
29TTK1.60280573
30FES1.60172990
31NEK91.56461879
32MKNK11.52541034
33CSNK1G11.50281072
34DAPK21.47513567
35DAPK11.45808797
36CDK191.44147406
37TRIM281.42993634
38TESK11.41369651
39SIK21.36679525
40TAOK21.35626146
41MAP3K91.34870417
42MAPK131.32681142
43PRKCG1.31855408
44SGK4941.30376701
45SGK2231.30376701
46CAMK2B1.30296666
47MAP3K61.29108830
48CAMK2A1.28336389
49LATS11.26846507
50CDC71.24676268
51KSR11.24521511
52BRSK21.21176822
53NME11.20374784
54DDR21.20245637
55PDGFRA1.18166329
56GRK51.17945711
57CCNB11.17156602
58CDK51.16828160
59ERBB41.16793421
60PNCK1.15036859
61MAP4K21.15001977
62NEK11.14906313
63PTK2B1.14380867
64CSNK1G31.13675689
65DYRK1A1.09523376
66PAK61.05202369
67CSNK1A1L1.04824060
68FER1.01981076
69SIK30.98366926
70ZAK0.98118513
71EPHB20.97220464
72PLK10.96565465
73SGK30.95260129
74STK30.95117480
75PLK40.91892715
76DYRK30.89190539
77PTK20.87630044
78ROCK10.86101997
79VRK20.85912840
80NTRK10.85743740
81ACVR1B0.84991015
82FGR0.84059489
83OXSR10.83600085
84CDK30.83590742
85STK380.83204405
86GRK10.82953986
87TNK20.79548452
88PRKCE0.78771698
89CAMKK10.78658453
90SGK10.77286400
91KSR20.76954191
92FLT30.76172356
93FGFR10.76114326
94STK240.75588703
95TTN0.74499108
96CAMK10.74357302
97CHEK20.72560371
98PBK0.72282534
99CAMK2D0.72224728
100TSSK60.71447577
101AURKB0.70927230
102STK160.70723736
103PRKD30.70202113
104PAK40.69651155
105INSRR0.68440090
106CLK10.66862973
107TGFBR10.66070416
108BRSK10.65970412
109MARK20.65611190
110YES10.63687829
111NLK0.62079143
112GRK70.60140754
113CAMKK20.59724144
114WEE10.59431696
115FRK0.59352997
116NUAK10.58996161
117DMPK0.54659439
118LATS20.54280163
119BRAF0.53995925
120TAF10.53264477
121MAP3K50.51335728
122PINK10.50665590
123CDK180.50519339
124MUSK0.49977638
125MAP3K70.49737046
126NEK20.49569696
127GRK60.48674411
128MAP3K20.48250859
129ROCK20.48007264
130CAMK2G0.46787600
131MAP3K100.46408756
132ATM0.46211966
133VRK10.44989992
134PRKD20.44652457
135CDK150.44379866
136CDK140.43987469
137MAP2K60.43880755
138PRKG10.42955386
139RPS6KA20.42056456
140PRKCH0.41983536
141PRKACA0.41387944
142RPS6KB10.41069531
143UHMK10.41027685
144ADRBK10.39525720
145CSNK1G20.38575926
146MAP3K130.38452741
147RAF10.38302206
148MAP2K10.37463520
149PHKG10.36760184
150PHKG20.36760184
151CDK11A0.36118059
152PAK30.34420291
153STK110.33783823
154RPS6KA30.32447773
155BMPR1B0.30397734
156PRKCZ0.29886307
157CAMK40.28897873
158PRKCB0.28889674
159PRKCA0.28299513
160ARAF0.26820897
161BCR0.26619432

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.88268953
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.21309735
3Circadian entrainment_Homo sapiens_hsa047133.00459873
4Synaptic vesicle cycle_Homo sapiens_hsa047212.99784378
5GABAergic synapse_Homo sapiens_hsa047272.89051701
6Morphine addiction_Homo sapiens_hsa050322.86578604
7Glutamatergic synapse_Homo sapiens_hsa047242.78855781
8Long-term potentiation_Homo sapiens_hsa047202.77709454
9Taste transduction_Homo sapiens_hsa047422.73978914
10Olfactory transduction_Homo sapiens_hsa047402.68841525
11Protein export_Homo sapiens_hsa030602.64877445
12Amphetamine addiction_Homo sapiens_hsa050312.51899484
13Serotonergic synapse_Homo sapiens_hsa047262.26466241
14Non-homologous end-joining_Homo sapiens_hsa034502.23104897
15Dopaminergic synapse_Homo sapiens_hsa047282.22616017
16Collecting duct acid secretion_Homo sapiens_hsa049662.14579918
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05276910
18Basal cell carcinoma_Homo sapiens_hsa052172.01189787
19Salivary secretion_Homo sapiens_hsa049701.98361850
20Hedgehog signaling pathway_Homo sapiens_hsa043401.94636759
21Long-term depression_Homo sapiens_hsa047301.94054679
22Hippo signaling pathway_Homo sapiens_hsa043901.93958418
23ECM-receptor interaction_Homo sapiens_hsa045121.92934345
24Insulin secretion_Homo sapiens_hsa049111.88335696
25Cholinergic synapse_Homo sapiens_hsa047251.82259118
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79967853
27Proteasome_Homo sapiens_hsa030501.79346661
28Calcium signaling pathway_Homo sapiens_hsa040201.78266377
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74569144
30Basal transcription factors_Homo sapiens_hsa030221.67538390
31Renin secretion_Homo sapiens_hsa049241.67240225
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66374304
33TGF-beta signaling pathway_Homo sapiens_hsa043501.63876212
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53318185
35Oxytocin signaling pathway_Homo sapiens_hsa049211.53297336
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52995833
37Fanconi anemia pathway_Homo sapiens_hsa034601.48557201
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47538085
39Cocaine addiction_Homo sapiens_hsa050301.38549300
40Phototransduction_Homo sapiens_hsa047441.37651443
41RNA polymerase_Homo sapiens_hsa030201.37230474
42Steroid biosynthesis_Homo sapiens_hsa001001.35925027
43Axon guidance_Homo sapiens_hsa043601.35235482
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35018770
45Gastric acid secretion_Homo sapiens_hsa049711.31733417
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30638044
47cAMP signaling pathway_Homo sapiens_hsa040241.30420439
48Mismatch repair_Homo sapiens_hsa034301.29944310
49Adherens junction_Homo sapiens_hsa045201.27863304
50Selenocompound metabolism_Homo sapiens_hsa004501.27699203
51Protein digestion and absorption_Homo sapiens_hsa049741.26814967
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26710360
53Vibrio cholerae infection_Homo sapiens_hsa051101.25507118
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25385050
55Tight junction_Homo sapiens_hsa045301.24732755
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21156084
57Homologous recombination_Homo sapiens_hsa034401.20992053
58Cell cycle_Homo sapiens_hsa041101.20268256
59GnRH signaling pathway_Homo sapiens_hsa049121.19554666
60RNA transport_Homo sapiens_hsa030131.17838657
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13327739
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13193984
63Focal adhesion_Homo sapiens_hsa045101.12183818
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11861742
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10447143
66Propanoate metabolism_Homo sapiens_hsa006401.08143230
67RNA degradation_Homo sapiens_hsa030181.06560416
68Type II diabetes mellitus_Homo sapiens_hsa049301.06464399
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06293384
70Nucleotide excision repair_Homo sapiens_hsa034201.04105943
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02709818
72Gap junction_Homo sapiens_hsa045401.01969816
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01956994
74cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00989935
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98229814
76Proteoglycans in cancer_Homo sapiens_hsa052050.95237802
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93778031
78Melanogenesis_Homo sapiens_hsa049160.93509329
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93073796
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.92736927
81ErbB signaling pathway_Homo sapiens_hsa040120.90312984
82Estrogen signaling pathway_Homo sapiens_hsa049150.89717705
83Folate biosynthesis_Homo sapiens_hsa007900.89371666
84Vitamin B6 metabolism_Homo sapiens_hsa007500.88947155
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88916291
86Cardiac muscle contraction_Homo sapiens_hsa042600.88142865
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.87966350
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86671593
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85956443
90Alzheimers disease_Homo sapiens_hsa050100.85804037
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84011204
92Oxidative phosphorylation_Homo sapiens_hsa001900.83964325
93Glioma_Homo sapiens_hsa052140.83430643
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79620181
95Base excision repair_Homo sapiens_hsa034100.79170176
96mRNA surveillance pathway_Homo sapiens_hsa030150.78461616
97Sulfur metabolism_Homo sapiens_hsa009200.77752874
98Ras signaling pathway_Homo sapiens_hsa040140.77345443
99Choline metabolism in cancer_Homo sapiens_hsa052310.77231806
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74210859
101Circadian rhythm_Homo sapiens_hsa047100.73608240
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73248726
103p53 signaling pathway_Homo sapiens_hsa041150.71215110
104Spliceosome_Homo sapiens_hsa030400.70271821
105MAPK signaling pathway_Homo sapiens_hsa040100.69500698
106DNA replication_Homo sapiens_hsa030300.68824451
107Purine metabolism_Homo sapiens_hsa002300.67762408
108Pancreatic secretion_Homo sapiens_hsa049720.67519375
109Wnt signaling pathway_Homo sapiens_hsa043100.67323972
110Butanoate metabolism_Homo sapiens_hsa006500.65891599
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65429496
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63183753
113Glutathione metabolism_Homo sapiens_hsa004800.62438717
114MicroRNAs in cancer_Homo sapiens_hsa052060.62126754
115Pyruvate metabolism_Homo sapiens_hsa006200.60823657
116N-Glycan biosynthesis_Homo sapiens_hsa005100.59957804
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58137482
118Dilated cardiomyopathy_Homo sapiens_hsa054140.57066307
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56195804
120Rap1 signaling pathway_Homo sapiens_hsa040150.55476615
121Rheumatoid arthritis_Homo sapiens_hsa053230.55399829
122Pathways in cancer_Homo sapiens_hsa052000.55347541
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54848347
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54669244
125Alcoholism_Homo sapiens_hsa050340.52952425
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52695574
127Oocyte meiosis_Homo sapiens_hsa041140.50249993
128Inositol phosphate metabolism_Homo sapiens_hsa005620.50173034
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49804851
130Pyrimidine metabolism_Homo sapiens_hsa002400.49095975
131Huntingtons disease_Homo sapiens_hsa050160.48628318
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47907378
133Type I diabetes mellitus_Homo sapiens_hsa049400.47905372
134beta-Alanine metabolism_Homo sapiens_hsa004100.47807786
135Arginine and proline metabolism_Homo sapiens_hsa003300.47503176
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46957694
137Biosynthesis of amino acids_Homo sapiens_hsa012300.46533269
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45808260
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45671667
140Metabolic pathways_Homo sapiens_hsa011000.44852826
141Glucagon signaling pathway_Homo sapiens_hsa049220.44646728
142Dorso-ventral axis formation_Homo sapiens_hsa043200.44255383
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.43067449
144African trypanosomiasis_Homo sapiens_hsa051430.42266753
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41379322
146Thyroid hormone synthesis_Homo sapiens_hsa049180.40550578
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37708201
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35332507
149Phagosome_Homo sapiens_hsa041450.34050644
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33697322
151Ovarian steroidogenesis_Homo sapiens_hsa049130.32909704
152Melanoma_Homo sapiens_hsa052180.29629897
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26068559
154Endometrial cancer_Homo sapiens_hsa052130.25819730
155Parkinsons disease_Homo sapiens_hsa050120.25643693
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.22351528
157VEGF signaling pathway_Homo sapiens_hsa043700.22257942
158Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21173819
159Regulation of autophagy_Homo sapiens_hsa041400.21081983
160Chemokine signaling pathway_Homo sapiens_hsa040620.20293163
161Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18936149
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.18346443
163Colorectal cancer_Homo sapiens_hsa052100.17562157
164Prion diseases_Homo sapiens_hsa050200.17086433
165FoxO signaling pathway_Homo sapiens_hsa040680.16245724
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12493604

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