TRIP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.20002356
2central nervous system myelination (GO:0022010)6.20002356
3fatty acid elongation (GO:0030497)5.46916619
4platelet dense granule organization (GO:0060155)5.07963184
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67525028
6L-phenylalanine catabolic process (GO:0006559)4.67525028
7presynaptic membrane assembly (GO:0097105)4.29428220
8aromatic amino acid family catabolic process (GO:0009074)4.23352147
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95826428
10L-phenylalanine metabolic process (GO:0006558)3.95826428
11bile acid biosynthetic process (GO:0006699)3.87482793
12DNA deamination (GO:0045006)3.82900778
13L-fucose catabolic process (GO:0042355)3.81224608
14fucose catabolic process (GO:0019317)3.81224608
15L-fucose metabolic process (GO:0042354)3.81224608
16tryptophan catabolic process (GO:0006569)3.80617393
17indole-containing compound catabolic process (GO:0042436)3.80617393
18indolalkylamine catabolic process (GO:0046218)3.80617393
19presynaptic membrane organization (GO:0097090)3.80491333
20activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.69942910
21cholesterol biosynthetic process (GO:0006695)3.65054210
22positive regulation of cellular amine metabolic process (GO:0033240)3.61446459
23myelination (GO:0042552)3.59845585
24very long-chain fatty acid metabolic process (GO:0000038)3.51649337
25ensheathment of neurons (GO:0007272)3.50062616
26axon ensheathment (GO:0008366)3.50062616
27tryptophan metabolic process (GO:0006568)3.45759290
28cellular biogenic amine catabolic process (GO:0042402)3.44150823
29amine catabolic process (GO:0009310)3.44150823
30long-chain fatty acid biosynthetic process (GO:0042759)3.38132931
31glyoxylate metabolic process (GO:0046487)3.37881753
32opsonization (GO:0008228)3.37633945
33glycerophospholipid catabolic process (GO:0046475)3.36553753
34eye photoreceptor cell differentiation (GO:0001754)3.36439058
35photoreceptor cell differentiation (GO:0046530)3.36439058
36anterograde synaptic vesicle transport (GO:0048490)3.36163194
37omega-hydroxylase P450 pathway (GO:0097267)3.28082968
38negative regulation of execution phase of apoptosis (GO:1900118)3.26612626
39protein neddylation (GO:0045116)3.26385973
40neuron cell-cell adhesion (GO:0007158)3.24675290
41limb bud formation (GO:0060174)3.21560898
42transmission of nerve impulse (GO:0019226)3.19979752
43neural tube formation (GO:0001841)3.17397643
44nucleotide transmembrane transport (GO:1901679)3.16112900
45regulation of collateral sprouting (GO:0048670)3.15122449
46DNA double-strand break processing (GO:0000729)3.13800910
47piRNA metabolic process (GO:0034587)3.11198693
48import into cell (GO:0098657)3.09568549
49regulation of fibrinolysis (GO:0051917)3.08193316
50oligodendrocyte differentiation (GO:0048709)3.06584445
51sterol biosynthetic process (GO:0016126)3.06203586
52kynurenine metabolic process (GO:0070189)3.05953032
53bile acid metabolic process (GO:0008206)3.03009350
54short-term memory (GO:0007614)2.97456508
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97136212
56very-low-density lipoprotein particle assembly (GO:0034379)2.94669727
57cullin deneddylation (GO:0010388)2.94250456
58regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.94153637
59L-amino acid import (GO:0043092)2.94079550
60response to xenobiotic stimulus (GO:0009410)2.90330439
61aromatic amino acid family metabolic process (GO:0009072)2.87714861
62negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.87065652
63negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.86948946
64axoneme assembly (GO:0035082)2.86678423
65response to methylmercury (GO:0051597)2.86313746
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84587604
67behavioral response to nicotine (GO:0035095)2.83807468
68NAD biosynthetic process (GO:0009435)2.83549951
69isoprenoid biosynthetic process (GO:0008299)2.81073511
70indolalkylamine metabolic process (GO:0006586)2.80831402
71pyrimidine-containing compound transmembrane transport (GO:0072531)2.77070286
72protein localization to cilium (GO:0061512)2.76511745
73protein deneddylation (GO:0000338)2.75231634
74respiratory chain complex IV assembly (GO:0008535)2.74636873
75protein-cofactor linkage (GO:0018065)2.73964168
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73947635
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73947635
78cell wall macromolecule catabolic process (GO:0016998)2.73179517
79complement activation, alternative pathway (GO:0006957)2.73089461
80proteasome assembly (GO:0043248)2.72229997
81long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.72048174
82protein carboxylation (GO:0018214)2.71728412
83peptidyl-glutamic acid carboxylation (GO:0017187)2.71728412
84coenzyme catabolic process (GO:0009109)2.65362261
85regulation of cilium movement (GO:0003352)2.65359700
86organelle disassembly (GO:1903008)2.64627082
87regulation of cholesterol esterification (GO:0010872)2.64560705
88negative regulation of lipase activity (GO:0060192)2.64078871
89positive regulation of defense response to virus by host (GO:0002230)2.64050908
90regulation of protein activation cascade (GO:2000257)2.63834743
91triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.63793713
92nucleotide transport (GO:0006862)2.62417358
93retina layer formation (GO:0010842)2.61910398
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61673928
95regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60933230
96high-density lipoprotein particle remodeling (GO:0034375)2.60335353
97tyrosine metabolic process (GO:0006570)2.60000345
98positive regulation of protein kinase C signaling (GO:0090037)2.59640112
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59309528
100regulation of interleukin-8 biosynthetic process (GO:0045414)2.58648378
101negative regulation of telomere maintenance (GO:0032205)2.57198005
102fatty-acyl-CoA biosynthetic process (GO:0046949)2.56668538
103blood coagulation, intrinsic pathway (GO:0007597)2.55873999
104response to redox state (GO:0051775)2.55519820
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54476352
106ubiquinone biosynthetic process (GO:0006744)2.54139856
107nicotinamide nucleotide biosynthetic process (GO:0019359)2.54052843
108pyridine nucleotide biosynthetic process (GO:0019363)2.54052843
109peroxisome fission (GO:0016559)2.53788669
110protein complex biogenesis (GO:0070271)2.53683465
111pyrimidine nucleobase catabolic process (GO:0006208)2.53162946
112response to interferon-beta (GO:0035456)2.53160089
113cilium morphogenesis (GO:0060271)2.52897777
114mannosylation (GO:0097502)2.52866975
115cholesterol efflux (GO:0033344)2.52776071
116aldehyde catabolic process (GO:0046185)2.52112750
117negative regulation of neurotransmitter secretion (GO:0046929)2.51783077
118alpha-linolenic acid metabolic process (GO:0036109)2.51260644
119regulation of timing of cell differentiation (GO:0048505)2.51092119
120preassembly of GPI anchor in ER membrane (GO:0016254)2.50512016
121positive regulation of cAMP-mediated signaling (GO:0043950)2.50057628
122fibrinolysis (GO:0042730)2.47863339
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47495585
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47495585
125signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47495585
126glucuronate metabolic process (GO:0019585)2.46593759
127uronic acid metabolic process (GO:0006063)2.46593759
128ribonucleoprotein complex disassembly (GO:0032988)2.46502069
129amino acid import (GO:0043090)2.46241911
130regulation of cellular amino acid metabolic process (GO:0006521)2.46193049
131cysteine metabolic process (GO:0006534)2.45651459
132nitrogen cycle metabolic process (GO:0071941)2.45569674
133intraciliary transport (GO:0042073)2.45251013
134regulation of complement activation (GO:0030449)2.45085651
135termination of RNA polymerase III transcription (GO:0006386)2.45074849
136transcription elongation from RNA polymerase III promoter (GO:0006385)2.45074849
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.43801461
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.43801461
139synapsis (GO:0007129)2.43513209
140activated T cell proliferation (GO:0050798)2.43305282
141neuron remodeling (GO:0016322)2.43253756
142peripheral nervous system axon ensheathment (GO:0032292)2.43083036
143myelination in peripheral nervous system (GO:0022011)2.43083036
144terpenoid biosynthetic process (GO:0016114)2.42430418
145long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.42114452
146nucleobase catabolic process (GO:0046113)2.42048428
147eosinophil chemotaxis (GO:0048245)2.41502976
148steroid biosynthetic process (GO:0006694)2.41371522
149glutathione derivative biosynthetic process (GO:1901687)2.40537720
150glutathione derivative metabolic process (GO:1901685)2.40537720
151C-terminal protein lipidation (GO:0006501)2.40308243
152water-soluble vitamin biosynthetic process (GO:0042364)2.40216613
153negative regulation of protein activation cascade (GO:2000258)2.39563218
154ubiquinone metabolic process (GO:0006743)2.39560015
155mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.38969812
156mitochondrial respiratory chain complex I assembly (GO:0032981)2.38969812
157NADH dehydrogenase complex assembly (GO:0010257)2.38969812
158fatty-acyl-CoA metabolic process (GO:0035337)2.38277036
159negative regulation of neurological system process (GO:0031645)2.37882112
160substantia nigra development (GO:0021762)2.37415024
161cellular glucuronidation (GO:0052695)2.37214793
162regulation of hexokinase activity (GO:1903299)2.36795408
163regulation of glucokinase activity (GO:0033131)2.36795408
164positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.36663147
165regulation of mitotic spindle checkpoint (GO:1903504)2.36607711
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.36607711
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.34723607
168positive regulation of interleukin-1 beta secretion (GO:0050718)2.34125518
169signal transduction involved in cell cycle checkpoint (GO:0072395)2.33655856
170C-terminal protein amino acid modification (GO:0018410)2.32434263
171male meiosis I (GO:0007141)2.30371147
172thrombin receptor signaling pathway (GO:0070493)2.30024164
173regulation of translation in response to stress (GO:0043555)2.29801277
174cellular response to interferon-beta (GO:0035458)2.29049864
175cytochrome complex assembly (GO:0017004)2.28898924
176mitochondrial respiratory chain complex assembly (GO:0033108)2.27571968
177signal transduction involved in DNA damage checkpoint (GO:0072422)2.27515187
178signal transduction involved in DNA integrity checkpoint (GO:0072401)2.27515187
179purine-containing compound salvage (GO:0043101)2.26743372
180DNA catabolic process, exonucleolytic (GO:0000738)2.26511482
181GPI anchor metabolic process (GO:0006505)2.26131630
182tyrosine phosphorylation of STAT protein (GO:0007260)2.25942862
183regulation of interleukin-1 beta secretion (GO:0050706)2.25476295
184establishment of protein localization to mitochondrial membrane (GO:0090151)2.24552254
185phosphatidylinositol acyl-chain remodeling (GO:0036149)2.23373199
186negative regulation of interleukin-12 production (GO:0032695)2.21255405
187fucose metabolic process (GO:0006004)2.20622438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.60199795
2EZH2_22144423_ChIP-Seq_EOC_Human3.29733568
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.22771319
4TAF15_26573619_Chip-Seq_HEK293_Human3.16712918
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10702413
6GBX2_23144817_ChIP-Seq_PC3_Human3.09601917
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.56628804
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.51589766
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47442469
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46620838
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31533329
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23634737
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21397415
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19484416
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.18610921
16ELK1_19687146_ChIP-ChIP_HELA_Human2.18168594
17IGF1R_20145208_ChIP-Seq_DFB_Human2.16958888
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10662800
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09117597
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08715582
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06867202
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.03580642
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.02053778
24EWS_26573619_Chip-Seq_HEK293_Human1.99129118
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98301218
26AR_21572438_ChIP-Seq_LNCaP_Human1.97644769
27* VDR_23849224_ChIP-Seq_CD4+_Human1.97616357
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93356674
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90249597
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.90211849
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.90006053
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.89957008
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88507407
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87555444
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85788830
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84102047
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79688980
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77369395
39* P300_19829295_ChIP-Seq_ESCs_Human1.76847335
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73751691
41ER_23166858_ChIP-Seq_MCF-7_Human1.72573518
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71934172
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71102653
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68198633
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68198633
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.64524180
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63332373
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.62131438
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61626535
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61244696
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.61045792
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60591383
53* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58846475
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.58606209
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57806231
56VDR_22108803_ChIP-Seq_LS180_Human1.56907581
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56676404
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.56039582
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54946290
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53672781
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53051257
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52300740
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51377158
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51080643
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50368306
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49934717
67FUS_26573619_Chip-Seq_HEK293_Human1.49174734
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.48960115
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.48832976
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.48791643
71P300_18555785_Chip-Seq_ESCs_Mouse1.48692517
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47780758
73* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47390370
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47279215
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46166758
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.46141216
77* ETS1_20019798_ChIP-Seq_JURKAT_Human1.45387367
78* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44849893
79RNF2_27304074_Chip-Seq_NSC_Mouse1.44481279
80P53_22387025_ChIP-Seq_ESCs_Mouse1.43917073
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43792921
82* FOXP3_21729870_ChIP-Seq_TREG_Human1.43660536
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.43037433
84LXR_22158963_ChIP-Seq_LIVER_Mouse1.42243204
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.40589329
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38907935
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38301856
88GATA3_26560356_Chip-Seq_TH2_Human1.37234455
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37214519
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.37137277
91TP53_22573176_ChIP-Seq_HFKS_Human1.35978948
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35257205
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34710966
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.33823982
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33568069
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.33506675
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32666879
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.32136344
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31826700
100* HTT_18923047_ChIP-ChIP_STHdh_Human1.31387948
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.29845992
102SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29578104
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29370712
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29334013
105* SMAD4_21799915_ChIP-Seq_A2780_Human1.28629622
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.28435785
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28260816
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.27627699
109NANOG_19829295_ChIP-Seq_ESCs_Human1.26334977
110SOX2_19829295_ChIP-Seq_ESCs_Human1.26334977
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25398282
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25296902
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24395336
114BCAT_22108803_ChIP-Seq_LS180_Human1.24249043
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.23858291
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22956403
117CBP_20019798_ChIP-Seq_JUKART_Human1.22956403
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.22168807
119PU1_27457419_Chip-Seq_LIVER_Mouse1.21162715
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20160536
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20013111
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20005562
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19671743
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18958541
125ZFX_18555785_Chip-Seq_ESCs_Mouse1.18558906
126CDX2_22108803_ChIP-Seq_LS180_Human1.17855184
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17747622
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17426980
129* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16484742
130AR_20517297_ChIP-Seq_VCAP_Human1.15976002
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14882633
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.11641878
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11210315
134* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11035668
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.10606617
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.10437063
137KDM2B_26808549_Chip-Seq_REH_Human1.09197620
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09167872
139FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09162268
140FOXA1_25329375_ChIP-Seq_VCAP_Human1.09162268
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09085535
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09085535
143AR_25329375_ChIP-Seq_VCAP_Human1.08546797
144IRF1_19129219_ChIP-ChIP_H3396_Human1.08391866
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07971286
146OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07808391
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05866574
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05866574
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05634505
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05618150
151MYC_18940864_ChIP-ChIP_HL60_Human1.02325880
152TCF4_22108803_ChIP-Seq_LS180_Human1.01801685
153CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00975049
154GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00772470
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99501489
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98274286
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97801892
158AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95633597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.90608594
2MP0004381_abnormal_hair_follicle3.76792547
3MP0002139_abnormal_hepatobiliary_system3.60176314
4MP0005409_darkened_coat_color3.53347196
5MP0005360_urolithiasis3.16586043
6MP0005085_abnormal_gallbladder_physiolo3.07566980
7MP0003880_abnormal_central_pattern2.96239717
8MP0003195_calcinosis2.92786991
9MP0008875_abnormal_xenobiotic_pharmacok2.67905460
10MP0001188_hyperpigmentation2.64798470
11MP0005084_abnormal_gallbladder_morpholo2.59609468
12MP0000920_abnormal_myelination2.57905003
13MP0005365_abnormal_bile_salt2.55529766
14MP0002837_dystrophic_cardiac_calcinosis2.49977709
15MP0000566_synostosis2.39447983
16MP0008789_abnormal_olfactory_epithelium2.30279262
17MP0008877_abnormal_DNA_methylation2.29823200
18MP0006054_spinal_hemorrhage2.29629905
19MP0009785_altered_susceptibility_to2.26695431
20MP0003690_abnormal_glial_cell2.25209774
21MP0006082_CNS_inflammation2.22483369
22MP0001835_abnormal_antigen_presentation2.19985312
23MP0002148_abnormal_hypersensitivity_rea2.16864976
24MP0005171_absent_coat_pigmentation2.13160819
25MP0009379_abnormal_foot_pigmentation2.12030300
26MP0005671_abnormal_response_to2.04328782
27MP0000569_abnormal_digit_pigmentation2.04209289
28MP0005167_abnormal_blood-brain_barrier1.94889693
29MP0004742_abnormal_vestibular_system1.93417588
30MP0001486_abnormal_startle_reflex1.85333862
31MP0008058_abnormal_DNA_repair1.85298235
32MP0005451_abnormal_body_composition1.83252000
33MP0002736_abnormal_nociception_after1.78540815
34MP0004142_abnormal_muscle_tone1.78448579
35MP0005551_abnormal_eye_electrophysiolog1.77788554
36MP0003186_abnormal_redox_activity1.77608302
37MP0005499_abnormal_olfactory_system1.68349014
38MP0005394_taste/olfaction_phenotype1.68349014
39MP0004147_increased_porphyrin_level1.66735424
40MP0002653_abnormal_ependyma_morphology1.65670226
41MP0003806_abnormal_nucleotide_metabolis1.63897401
42MP0002138_abnormal_hepatobiliary_system1.61765920
43MP0003011_delayed_dark_adaptation1.55782377
44MP0000015_abnormal_ear_pigmentation1.55770607
45MP0002876_abnormal_thyroid_physiology1.55128641
46MP0005387_immune_system_phenotype1.54014985
47MP0001790_abnormal_immune_system1.54014985
48MP0006292_abnormal_olfactory_placode1.50562264
49MP0005379_endocrine/exocrine_gland_phen1.46994917
50MP0002272_abnormal_nervous_system1.45438395
51MP0003868_abnormal_feces_composition1.44569670
52MP0001905_abnormal_dopamine_level1.43465932
53MP0005000_abnormal_immune_tolerance1.37025902
54MP0003938_abnormal_ear_development1.36837771
55MP0003950_abnormal_plasma_membrane1.35709149
56MP0002064_seizures1.35303252
57MP0009745_abnormal_behavioral_response1.34875241
58MP0001529_abnormal_vocalization1.34347156
59MP0000685_abnormal_immune_system1.33421088
60MP0001661_extended_life_span1.30401322
61MP0009697_abnormal_copulation1.29654233
62MP0005646_abnormal_pituitary_gland1.29368144
63MP0001764_abnormal_homeostasis1.28158905
64MP0003252_abnormal_bile_duct1.28100967
65MP0000516_abnormal_urinary_system1.27040383
66MP0005367_renal/urinary_system_phenotyp1.27040383
67MP0001984_abnormal_olfaction1.26898843
68MP0001800_abnormal_humoral_immune1.26435650
69MP0000778_abnormal_nervous_system1.24168944
70MP0002332_abnormal_exercise_endurance1.23678047
71MP0001845_abnormal_inflammatory_respons1.22177275
72MP0006276_abnormal_autonomic_nervous1.21066494
73MP0002723_abnormal_immune_serum1.20802581
74MP0003303_peritoneal_inflammation1.20387025
75MP0005423_abnormal_somatic_nervous1.20315082
76MP0002452_abnormal_antigen_presenting1.20064315
77MP0000462_abnormal_digestive_system1.19372177
78MP0005332_abnormal_amino_acid1.17768810
79MP0001986_abnormal_taste_sensitivity1.17509804
80MP0001666_abnormal_nutrient_absorption1.15485602
81MP0010329_abnormal_lipoprotein_level1.14919178
82MP0006036_abnormal_mitochondrial_physio1.14807372
83MP0005408_hypopigmentation1.13333297
84MP0005025_abnormal_response_to1.11700530
85MP0008872_abnormal_physiological_respon1.10924515
86MP0001485_abnormal_pinna_reflex1.10474686
87MP0002102_abnormal_ear_morphology1.10172662
88MP0001968_abnormal_touch/_nociception1.07513319
89MP0000026_abnormal_inner_ear1.07305304
90MP0001324_abnormal_eye_pigmentation1.07145836
91MP0005647_abnormal_sex_gland1.06513286
92MP0002229_neurodegeneration1.06099243
93MP0001963_abnormal_hearing_physiology1.05824683
94MP0002095_abnormal_skin_pigmentation1.05767228
95MP0006035_abnormal_mitochondrial_morpho1.04881744
96MP0000427_abnormal_hair_cycle1.04238609
97MP0002419_abnormal_innate_immunity1.03769868
98MP0003724_increased_susceptibility_to1.03737937
99MP0002067_abnormal_sensory_capabilities1.03634474
100MP0010386_abnormal_urinary_bladder1.02960859
101MP0005310_abnormal_salivary_gland1.02915408
102MP0003172_abnormal_lysosome_physiology1.02716182
103MP0004270_analgesia1.01629471
104MP0001819_abnormal_immune_cell1.00219156
105MP0005253_abnormal_eye_physiology0.99488205
106MP0002420_abnormal_adaptive_immunity0.98932263
107MP0002118_abnormal_lipid_homeostasis0.97983706
108MP0002822_catalepsy0.97263793
109MP0001346_abnormal_lacrimal_gland0.97083563
110MP0002572_abnormal_emotion/affect_behav0.96214138
111MP0000631_abnormal_neuroendocrine_gland0.95305533
112MP0002752_abnormal_somatic_nervous0.95257221
113MP0005195_abnormal_posterior_eye0.94885650
114MP0002254_reproductive_system_inflammat0.93696829
115MP0003634_abnormal_glial_cell0.93691590
116MP0009046_muscle_twitch0.92210342
117MP0001440_abnormal_grooming_behavior0.92078402
118MP0000647_abnormal_sebaceous_gland0.91971439
119MP0004885_abnormal_endolymph0.90780510
120MP0004019_abnormal_vitamin_homeostasis0.90059556
121MP0005464_abnormal_platelet_physiology0.90002309
122MP0002277_abnormal_respiratory_mucosa0.86955122
123MP0002638_abnormal_pupillary_reflex0.86007695
124MP0002909_abnormal_adrenal_gland0.84896996
125MP0009765_abnormal_xenobiotic_induced0.84580474
126MP0008469_abnormal_protein_level0.84287473
127MP0002751_abnormal_autonomic_nervous0.84285084
128MP0005410_abnormal_fertilization0.84024905
129MP0010155_abnormal_intestine_physiology0.83978932
130MP0003787_abnormal_imprinting0.82957032
131MP0000579_abnormal_nail_morphology0.82643988
132MP0003635_abnormal_synaptic_transmissio0.82021644
133MP0004215_abnormal_myocardial_fiber0.81885073
134MP0003718_maternal_effect0.80960783
135MP0001177_atelectasis0.80553618
136MP0000689_abnormal_spleen_morphology0.80505555
137MP0009764_decreased_sensitivity_to0.80082114
138MP0001853_heart_inflammation0.79926559
139MP0002090_abnormal_vision0.79555467
140MP0000383_abnormal_hair_follicle0.79548035
141MP0000371_diluted_coat_color0.79510572
142MP0006072_abnormal_retinal_apoptosis0.79154673
143MP0003937_abnormal_limbs/digits/tail_de0.77851405
144MP0001502_abnormal_circadian_rhythm0.77172461
145MP0003436_decreased_susceptibility_to0.77121796
146MP0005083_abnormal_biliary_tract0.76459786
147MP0003632_abnormal_nervous_system0.76251608
148MP0000613_abnormal_salivary_gland0.75797118
149MP0002882_abnormal_neuron_morphology0.75638733
150MP0000358_abnormal_cell_content/0.75281104
151MP0002405_respiratory_system_inflammati0.73788997
152MP0009384_cardiac_valve_regurgitation0.73520490
153MP0009250_abnormal_appendicular_skeleto0.73349710
154MP0002938_white_spotting0.73323520
155MP0002557_abnormal_social/conspecific_i0.72101563
156MP0002734_abnormal_mechanical_nocicepti0.71763060
157MP0003121_genomic_imprinting0.71596063
158MP0004883_abnormal_blood_vessel0.71522727
159MP0004133_heterotaxia0.71202665
160MP0002928_abnormal_bile_duct0.71117241
161MP0002735_abnormal_chemical_nociception0.70360658
162MP0001919_abnormal_reproductive_system0.69710077
163MP0000372_irregular_coat_pigmentation0.68971688
164MP0000762_abnormal_tongue_morphology0.68258406
165MP0005075_abnormal_melanosome_morpholog0.68176873
166MP0005645_abnormal_hypothalamus_physiol0.67930337
167MP0008260_abnormal_autophagy0.66958075
168MP0002163_abnormal_gland_morphology0.64863257

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.49868152
2Stomatitis (HP:0010280)4.37910844
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.08717014
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.08717014
5Intrahepatic cholestasis (HP:0001406)4.03626416
6Pancreatic cysts (HP:0001737)3.70620075
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46438083
8Pancreatic fibrosis (HP:0100732)3.41930730
9Abnormality of incisor morphology (HP:0011063)3.37782689
10Abnormality of secondary sexual hair (HP:0009888)3.37197712
11Abnormality of the axillary hair (HP:0100134)3.37197712
12Hyperlipoproteinemia (HP:0010980)3.24916666
13Parakeratosis (HP:0001036)3.15768688
14True hermaphroditism (HP:0010459)3.06765148
15Molar tooth sign on MRI (HP:0002419)3.00153340
16Abnormality of midbrain morphology (HP:0002418)3.00153340
17Conjugated hyperbilirubinemia (HP:0002908)2.97578272
18Nephronophthisis (HP:0000090)2.95679717
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94471962
20Joint hemorrhage (HP:0005261)2.91806443
21Abnormality of the corticospinal tract (HP:0002492)2.90740100
22Abnormality of the renal cortex (HP:0011035)2.88503824
23Increased CSF lactate (HP:0002490)2.81214741
24Neurofibrillary tangles (HP:0002185)2.79998651
25Renal cortical cysts (HP:0000803)2.73933785
26Sensory axonal neuropathy (HP:0003390)2.73736956
27Hypobetalipoproteinemia (HP:0003563)2.73491505
28Anomalous pulmonary venous return (HP:0010772)2.68391537
29Conical tooth (HP:0000698)2.63979996
30Type 2 muscle fiber atrophy (HP:0003554)2.59074593
31Deep venous thrombosis (HP:0002625)2.58738069
32Abnormality of macular pigmentation (HP:0008002)2.58577516
33Abnormality of the renal medulla (HP:0100957)2.57150419
34Medial flaring of the eyebrow (HP:0010747)2.56409772
35Abnormality of methionine metabolism (HP:0010901)2.53788054
36Renal Fanconi syndrome (HP:0001994)2.52584095
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51148241
38Septo-optic dysplasia (HP:0100842)2.50866522
39Xanthomatosis (HP:0000991)2.49081460
40Absent/shortened dynein arms (HP:0200106)2.48154482
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.48154482
42Optic disc pallor (HP:0000543)2.47182436
43Complement deficiency (HP:0004431)2.46525917
44Abolished electroretinogram (ERG) (HP:0000550)2.45651029
45Decreased central vision (HP:0007663)2.45008998
46Hypophosphatemic rickets (HP:0004912)2.44790994
47Hepatocellular necrosis (HP:0001404)2.43364733
48Synostosis involving the elbow (HP:0003938)2.43108574
49Humeroradial synostosis (HP:0003041)2.43108574
50Hepatic necrosis (HP:0002605)2.42248161
51Hyperglycinemia (HP:0002154)2.37235483
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36315350
53Abnormality of the pulmonary veins (HP:0011718)2.34739538
54Fat malabsorption (HP:0002630)2.34643754
55White forelock (HP:0002211)2.31281537
56Patchy hypopigmentation of hair (HP:0011365)2.30687539
57Polyphagia (HP:0002591)2.30519570
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30197772
593-Methylglutaconic aciduria (HP:0003535)2.29079337
60Fair hair (HP:0002286)2.28270828
61Methylmalonic aciduria (HP:0012120)2.27714428
62Amyotrophic lateral sclerosis (HP:0007354)2.27499726
63Acute encephalopathy (HP:0006846)2.26297572
64Acute necrotizing encephalopathy (HP:0006965)2.25553392
65Abnormal rod and cone electroretinograms (HP:0008323)2.23875639
66Albinism (HP:0001022)2.22895856
67IgG deficiency (HP:0004315)2.21221078
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21030891
69Abnormal protein N-linked glycosylation (HP:0012347)2.21030891
70Abnormal protein glycosylation (HP:0012346)2.21030891
71Abnormal glycosylation (HP:0012345)2.21030891
72Absent septum pellucidum (HP:0001331)2.20633336
73Cupped ear (HP:0000378)2.19052070
74Abnormality of glycolipid metabolism (HP:0010969)2.17765841
75Abnormality of liposaccharide metabolism (HP:0010968)2.17765841
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.17765841
77Cerebral edema (HP:0002181)2.15721784
78Chronic mucocutaneous candidiasis (HP:0002728)2.15601363
79Recurrent cutaneous fungal infections (HP:0011370)2.15601363
80Pendular nystagmus (HP:0012043)2.14643164
81Anencephaly (HP:0002323)2.14157481
82Abnormality of glycine metabolism (HP:0010895)2.13431467
83Abnormality of serine family amino acid metabolism (HP:0010894)2.13431467
84Scanning speech (HP:0002168)2.12229479
85Steatorrhea (HP:0002570)2.09872072
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09162728
87Abnormality of the septum pellucidum (HP:0007375)2.07673781
88Progressive macrocephaly (HP:0004481)2.07237242
89Tubular atrophy (HP:0000092)2.04712003
90Generalized aminoaciduria (HP:0002909)2.04165360
91Split foot (HP:0001839)2.03941728
92Hypoplastic nipples (HP:0002557)2.02360220
93Erythroderma (HP:0001019)2.02064447
94Abnormality of the common coagulation pathway (HP:0010990)2.01992524
95Abnormal ciliary motility (HP:0012262)2.01094506
96Cutaneous melanoma (HP:0012056)1.99491754
97Abnormality of serum amino acid levels (HP:0003112)1.98670821
98Abnormal pupillary function (HP:0007686)1.98129539
99Increased serum lactate (HP:0002151)1.98091905
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.97665188
101Muscle fiber atrophy (HP:0100295)1.96447190
102Vacuolated lymphocytes (HP:0001922)1.96157051
103Congenital sensorineural hearing impairment (HP:0008527)1.96029882
104Abnormal biliary tract physiology (HP:0012439)1.95757899
105Bile duct proliferation (HP:0001408)1.95757899
106Congenital primary aphakia (HP:0007707)1.95366487
107Aplasia involving bones of the upper limbs (HP:0009823)1.95303745
108Aplasia of the phalanges of the hand (HP:0009802)1.95303745
109Aplasia involving bones of the extremities (HP:0009825)1.95303745
110Atrophy/Degeneration involving motor neurons (HP:0007373)1.94881288
111Abnormal respiratory motile cilium physiology (HP:0012261)1.94710356
112Nephrogenic diabetes insipidus (HP:0009806)1.93842602
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93371305
114Increased hepatocellular lipid droplets (HP:0006565)1.92710102
115Abnormal respiratory motile cilium morphology (HP:0005938)1.92344120
116Abnormal respiratory epithelium morphology (HP:0012253)1.92344120
117Congenital stationary night blindness (HP:0007642)1.91642175
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91228646
119Leukodystrophy (HP:0002415)1.90514298
120Sclerocornea (HP:0000647)1.90359525
121Pachygyria (HP:0001302)1.89789524
122Hyperventilation (HP:0002883)1.89219725
123Gait imbalance (HP:0002141)1.88846374
124Cystic liver disease (HP:0006706)1.88740329
125Methylmalonic acidemia (HP:0002912)1.88442271
126Abnormality of the parathyroid morphology (HP:0011766)1.88065124
127Mitochondrial inheritance (HP:0001427)1.87543019
128Thyroiditis (HP:0100646)1.87118768
129Type II lissencephaly (HP:0007260)1.87055626
130Sex reversal (HP:0012245)1.85955480
131Abnormal sex determination (HP:0012244)1.85955480
132Alacrima (HP:0000522)1.85904521
133Lactic acidosis (HP:0003128)1.85673097
134Spastic paraparesis (HP:0002313)1.85613141
135Increased IgM level (HP:0003496)1.85429217
136Amyloidosis (HP:0011034)1.85151423
137Lissencephaly (HP:0001339)1.83884472
138Stomach cancer (HP:0012126)1.83556677
139Lipid accumulation in hepatocytes (HP:0006561)1.82574866
140Hypoproteinemia (HP:0003075)1.82208521
141Mutism (HP:0002300)1.82016991
142Hypothermia (HP:0002045)1.81869417
143Thick nail (HP:0001805)1.79737828
144Epidermoid cyst (HP:0200040)1.79702870
145Attenuation of retinal blood vessels (HP:0007843)1.79066544
146Disproportionate short-trunk short stature (HP:0003521)1.78802615
147Nausea (HP:0002018)1.78402875
148Optic nerve hypoplasia (HP:0000609)1.78236858
149Abnormal delayed hypersensitivity skin test (HP:0002963)1.77117458
150Retrobulbar optic neuritis (HP:0100654)1.76952756
151Optic neuritis (HP:0100653)1.76952756
152Congenital hepatic fibrosis (HP:0002612)1.76817409
153Confusion (HP:0001289)1.76241359
154Exertional dyspnea (HP:0002875)1.76186478
155Chronic hepatic failure (HP:0100626)1.75524533
156Recurrent fungal infections (HP:0002841)1.75493270
157Prolonged neonatal jaundice (HP:0006579)1.75256414
158Peripheral hypomyelination (HP:0007182)1.75072174
159Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74402671
160Blue irides (HP:0000635)1.74215513
161Chin dimple (HP:0010751)1.73931732
162Widely spaced teeth (HP:0000687)1.73799596
163Abnormality of B cell number (HP:0010975)1.73736071
164Bifid scrotum (HP:0000048)1.73454113
165Glycosuria (HP:0003076)1.73420613
166Abnormality of urine glucose concentration (HP:0011016)1.73420613
167Type I transferrin isoform profile (HP:0003642)1.72834103
168Partial agenesis of the corpus callosum (HP:0001338)1.72796899
169Abnormality of dental color (HP:0011073)1.71520980
170Abnormal mitochondria in muscle tissue (HP:0008316)1.71438024
171Amniotic constriction ring (HP:0009775)1.70731660
172Abnormality of placental membranes (HP:0011409)1.70731660
173Abnormality of renal resorption (HP:0011038)1.69855360
174Lethargy (HP:0001254)1.69019797
175Hyperglycinuria (HP:0003108)1.68113631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.31578328
2TNIK5.28162394
3TRIM283.67743861
4STK393.50643711
5FRK3.28151346
6MAP4K23.26213813
7EIF2AK32.58062710
8ACVR1B2.44605419
9MKNK22.37089453
10PKN12.27979084
11OXSR12.26396598
12WNK32.03640788
13EPHB11.99289256
14PINK11.93644585
15PBK1.77090787
16SIK31.74684527
17IRAK11.73400690
18TLK11.72275746
19ERBB31.64369293
20MAP3K121.61919014
21NEK61.61187535
22IRAK21.60431156
23INSRR1.58674641
24TIE11.54902420
25BCR1.54027016
26MST41.53493067
27STK161.50723453
28MKNK11.47808096
29CLK11.46481920
30MAP2K71.38457809
31FES1.36304057
32EIF2AK11.35452583
33ADRBK21.32688230
34ERBB41.30865070
35FGR1.29139726
36IRAK41.27214912
37EPHA41.24739387
38MAPK151.23636987
39MAPK131.21476626
40MATK1.21025369
41IRAK31.20387699
42PHKG21.19403989
43PHKG11.19403989
44GRK11.17828112
45BMPR21.17277517
46WNK41.15537895
47GRK71.12421351
48NLK1.10710282
49CAMKK21.09953943
50FGFR21.07928123
51MAP3K31.06982879
52MUSK1.04989022
53PNCK1.04506860
54TGFBR11.01952815
55PIK3CG1.01606691
56DYRK31.01346333
57NEK11.00144682
58UHMK10.99415238
59DYRK20.97347671
60SGK2230.94555556
61SGK4940.94555556
62CAMK2A0.92529244
63PRKCE0.92112299
64CAMK2B0.90423839
65NUAK10.89925003
66FER0.85456499
67CSNK1G10.85132462
68PRPF4B0.84975551
69DYRK1A0.84070490
70PRKCQ0.82396941
71CAMK2G0.80764775
72CDK30.80543429
73SRPK10.80515540
74YES10.78320126
75CSNK1A1L0.77482399
76CAMK2D0.76857381
77MARK10.75829274
78BLK0.75007588
79MARK30.74765518
80MET0.73984389
81EIF2AK20.73963960
82BRD40.73259481
83CSNK1G30.72935341
84MAP2K40.72465563
85TEC0.70812314
86IKBKB0.68558153
87MAPKAPK50.68463134
88KSR10.67343108
89TAOK30.65509958
90WNK10.65040067
91PRKG10.63335787
92MAPKAPK30.62471126
93NTRK30.62443319
94MAP3K140.62161070
95MAP3K40.61251437
96PIK3CA0.59617477
97TNK20.59517829
98ROCK20.59297550
99GRK50.58024039
100JAK30.57034886
101TXK0.55807816
102LYN0.55188861
103ADRBK10.55060547
104MAP3K50.54795583
105PLK30.54504310
106KIT0.53865517
107ABL10.52574201
108BRSK20.52419879
109CSNK1G20.50438602
110PRKACA0.50256762
111EPHA30.46107757
112ABL20.45120488
113CSK0.44908021
114STK240.44878654
115PLK40.44780660
116NME10.44750988
117PRKCI0.44004439
118STK30.43974908
119TGFBR20.43559564
120CCNB10.42990842
121CDK190.41385967
122* EGFR0.40029845
123PRKCG0.39989628
124PTK2B0.39802513
125BMPR1B0.39568424
126ZAK0.39205275
127PRKAA20.38744755
128GSK3A0.38633520
129PAK30.38110171
130IKBKE0.37744628
131AKT30.36820832
132PLK20.36411379
133BCKDK0.36355821
134FYN0.36299664
135NTRK20.35321738
136TYRO30.34935888
137RPS6KA50.34262897
138NTRK10.34153276
139PDK20.33620070
140LIMK10.33379664
141CDK50.33261830
142CSNK1A10.33217507
143PRKD20.33036443
144PIM20.32658039
145STK38L0.32475536
146LCK0.32260563
147TYK20.31745343
148SYK0.31646008
149MYLK0.31523424
150CSNK2A10.30230751
151CDK80.29712194
152VRK10.29200409
153DAPK10.29195523
154IGF1R0.28059489

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.56123670
2Steroid biosynthesis_Homo sapiens_hsa001003.32486954
3Proteasome_Homo sapiens_hsa030503.28892651
4Fatty acid elongation_Homo sapiens_hsa000623.15126953
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71805750
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68734947
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68109659
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61570198
9Sulfur metabolism_Homo sapiens_hsa009202.49311685
10Asthma_Homo sapiens_hsa053102.44148039
11Histidine metabolism_Homo sapiens_hsa003402.36911606
12Basal transcription factors_Homo sapiens_hsa030222.32234839
13Allograft rejection_Homo sapiens_hsa053302.27818956
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25478325
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20754578
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13739960
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.12613020
18Non-homologous end-joining_Homo sapiens_hsa034502.12204208
19Butanoate metabolism_Homo sapiens_hsa006502.11931949
20Peroxisome_Homo sapiens_hsa041462.08401124
21Complement and coagulation cascades_Homo sapiens_hsa046102.00211713
22RNA polymerase_Homo sapiens_hsa030201.95982134
23Vitamin B6 metabolism_Homo sapiens_hsa007501.95155283
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.93381789
25Ether lipid metabolism_Homo sapiens_hsa005651.91450085
26Tryptophan metabolism_Homo sapiens_hsa003801.88218317
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83484962
28Oxidative phosphorylation_Homo sapiens_hsa001901.82088168
29Retinol metabolism_Homo sapiens_hsa008301.81205037
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81172666
31Type I diabetes mellitus_Homo sapiens_hsa049401.73145257
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71854323
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71053298
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67134208
35Chemical carcinogenesis_Homo sapiens_hsa052041.66629018
36beta-Alanine metabolism_Homo sapiens_hsa004101.55483637
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52245139
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49594794
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44298908
40Protein export_Homo sapiens_hsa030601.43201995
41Phototransduction_Homo sapiens_hsa047441.43072140
42Nitrogen metabolism_Homo sapiens_hsa009101.42694231
43Fatty acid degradation_Homo sapiens_hsa000711.35995684
44Legionellosis_Homo sapiens_hsa051341.35177824
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34457345
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31121468
47Selenocompound metabolism_Homo sapiens_hsa004501.27417634
48Fatty acid metabolism_Homo sapiens_hsa012121.27172538
49Propanoate metabolism_Homo sapiens_hsa006401.18302964
50Linoleic acid metabolism_Homo sapiens_hsa005911.17808840
51ABC transporters_Homo sapiens_hsa020101.17128913
52Tyrosine metabolism_Homo sapiens_hsa003501.14635116
53Viral myocarditis_Homo sapiens_hsa054161.12966560
54Vitamin digestion and absorption_Homo sapiens_hsa049771.12472057
55Arginine biosynthesis_Homo sapiens_hsa002201.12350264
56Arginine and proline metabolism_Homo sapiens_hsa003301.10878276
57PPAR signaling pathway_Homo sapiens_hsa033201.10814532
58Staphylococcus aureus infection_Homo sapiens_hsa051501.09372153
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08870805
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08186189
61Nicotine addiction_Homo sapiens_hsa050331.07558463
62Primary immunodeficiency_Homo sapiens_hsa053401.06993627
63Lysosome_Homo sapiens_hsa041421.06659760
64Homologous recombination_Homo sapiens_hsa034401.05112451
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04893859
66Glycosaminoglycan degradation_Homo sapiens_hsa005311.04727334
67Alzheimers disease_Homo sapiens_hsa050101.03432739
68Sphingolipid metabolism_Homo sapiens_hsa006001.00594483
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00040910
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98420045
71Parkinsons disease_Homo sapiens_hsa050120.98161607
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97240183
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96351438
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94627360
75RNA degradation_Homo sapiens_hsa030180.94584084
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.93485688
77Antigen processing and presentation_Homo sapiens_hsa046120.91150788
78Arachidonic acid metabolism_Homo sapiens_hsa005900.90386109
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90223170
80Fanconi anemia pathway_Homo sapiens_hsa034600.89780975
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89648843
82Glutathione metabolism_Homo sapiens_hsa004800.88494830
83Hematopoietic cell lineage_Homo sapiens_hsa046400.83633787
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83021497
85Serotonergic synapse_Homo sapiens_hsa047260.81607782
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80047684
87GABAergic synapse_Homo sapiens_hsa047270.79137652
88Glutamatergic synapse_Homo sapiens_hsa047240.79115787
89Phenylalanine metabolism_Homo sapiens_hsa003600.78713435
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77247525
91Caffeine metabolism_Homo sapiens_hsa002320.77064494
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76080573
93Tuberculosis_Homo sapiens_hsa051520.74751304
94Axon guidance_Homo sapiens_hsa043600.72420710
95Folate biosynthesis_Homo sapiens_hsa007900.71563753
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69096207
97Ovarian steroidogenesis_Homo sapiens_hsa049130.68972097
98Pyrimidine metabolism_Homo sapiens_hsa002400.68855791
99Bile secretion_Homo sapiens_hsa049760.67959936
100Phagosome_Homo sapiens_hsa041450.67818889
101Metabolic pathways_Homo sapiens_hsa011000.66713674
102Morphine addiction_Homo sapiens_hsa050320.59754335
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.59528423
104Huntingtons disease_Homo sapiens_hsa050160.58224414
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57827164
106Pyruvate metabolism_Homo sapiens_hsa006200.56649835
107Leishmaniasis_Homo sapiens_hsa051400.54029833
108RNA transport_Homo sapiens_hsa030130.53863292
109Fatty acid biosynthesis_Homo sapiens_hsa000610.53595060
110Salmonella infection_Homo sapiens_hsa051320.53590223
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.53441803
112Pertussis_Homo sapiens_hsa051330.53152032
113Fat digestion and absorption_Homo sapiens_hsa049750.52816046
114Starch and sucrose metabolism_Homo sapiens_hsa005000.52505000
115Herpes simplex infection_Homo sapiens_hsa051680.51108183
116p53 signaling pathway_Homo sapiens_hsa041150.50836097
117Collecting duct acid secretion_Homo sapiens_hsa049660.49720543
118Autoimmune thyroid disease_Homo sapiens_hsa053200.48778972
119Measles_Homo sapiens_hsa051620.46585460
120Shigellosis_Homo sapiens_hsa051310.45142059
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44914203
122Purine metabolism_Homo sapiens_hsa002300.43853153
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.43598080
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41687534
125Sulfur relay system_Homo sapiens_hsa041220.41118749
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40958907
127Taste transduction_Homo sapiens_hsa047420.39196666
128Long-term depression_Homo sapiens_hsa047300.37974161
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.36379713
130Glycerolipid metabolism_Homo sapiens_hsa005610.36054056
131Toxoplasmosis_Homo sapiens_hsa051450.30772162
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30104446
133Graft-versus-host disease_Homo sapiens_hsa053320.30066883
134Rheumatoid arthritis_Homo sapiens_hsa053230.29549051
135Prion diseases_Homo sapiens_hsa050200.27942425
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24421577
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.23534732
138Cardiac muscle contraction_Homo sapiens_hsa042600.22052656
139Ras signaling pathway_Homo sapiens_hsa040140.20248779
140African trypanosomiasis_Homo sapiens_hsa051430.18759413
141Malaria_Homo sapiens_hsa051440.18722412
142Other glycan degradation_Homo sapiens_hsa005110.16547473
143Cholinergic synapse_Homo sapiens_hsa047250.15464619
144Regulation of autophagy_Homo sapiens_hsa041400.14923247
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.12592194
146Vibrio cholerae infection_Homo sapiens_hsa051100.12588375

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