TRIP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.15229623
2nuclear pore organization (GO:0006999)6.60307607
3piRNA metabolic process (GO:0034587)6.59408977
4synaptonemal complex assembly (GO:0007130)5.64028910
5male meiosis (GO:0007140)5.53530259
6synaptonemal complex organization (GO:0070193)5.38144721
7pore complex assembly (GO:0046931)5.31281756
8mitotic sister chromatid cohesion (GO:0007064)5.11933192
9cilium or flagellum-dependent cell motility (GO:0001539)4.94426058
10monoubiquitinated protein deubiquitination (GO:0035520)4.72605006
11regulation of RNA export from nucleus (GO:0046831)4.71365997
12DNA methylation involved in gamete generation (GO:0043046)4.59529533
13gene silencing by RNA (GO:0031047)4.54405135
14regulation of histone H3-K9 methylation (GO:0051570)4.53399179
15regulation of meiosis I (GO:0060631)4.48488407
16fusion of sperm to egg plasma membrane (GO:0007342)4.39323268
17pre-miRNA processing (GO:0031054)4.35086082
18negative regulation of histone methylation (GO:0031061)4.22942509
19chromosome organization involved in meiosis (GO:0070192)4.15893830
20regulation of centriole replication (GO:0046599)4.15424253
21mitotic chromosome condensation (GO:0007076)4.08266671
22heterochromatin organization (GO:0070828)4.07817699
23histone H3-K36 demethylation (GO:0070544)4.05170638
24acrosome assembly (GO:0001675)3.92194025
25meiotic nuclear division (GO:0007126)3.92085167
26regulation of nucleobase-containing compound transport (GO:0032239)3.85633963
27hypotonic response (GO:0006971)3.83623721
28mitotic nuclear envelope disassembly (GO:0007077)3.74956902
29histone H2A monoubiquitination (GO:0035518)3.74893842
30sperm-egg recognition (GO:0035036)3.72722795
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72638642
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72638642
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.72638642
34binding of sperm to zona pellucida (GO:0007339)3.72115286
35gene silencing (GO:0016458)3.69169771
36male meiosis I (GO:0007141)3.66266496
37DNA replication-dependent nucleosome organization (GO:0034723)3.63418722
38DNA replication-dependent nucleosome assembly (GO:0006335)3.63418722
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62539453
40nuclear envelope disassembly (GO:0051081)3.62530640
41membrane disassembly (GO:0030397)3.62530640
42sister chromatid cohesion (GO:0007062)3.60584163
43spermatid development (GO:0007286)3.59860007
44NLS-bearing protein import into nucleus (GO:0006607)3.57222787
45regulation of gene silencing by RNA (GO:0060966)3.54922112
46regulation of posttranscriptional gene silencing (GO:0060147)3.54922112
47regulation of gene silencing by miRNA (GO:0060964)3.54922112
48cytoplasmic mRNA processing body assembly (GO:0033962)3.48151981
49regulation of sister chromatid cohesion (GO:0007063)3.45602297
50chromatin assembly (GO:0031497)3.45488303
51DNA methylation (GO:0006306)3.43454055
52DNA alkylation (GO:0006305)3.43454055
53sister chromatid segregation (GO:0000819)3.41465692
54cell-cell recognition (GO:0009988)3.39351742
55sperm motility (GO:0030317)3.36979872
56positive regulation of chromosome segregation (GO:0051984)3.35285411
57protein localization to chromosome, centromeric region (GO:0071459)3.31648283
58regulation of mitotic spindle organization (GO:0060236)3.29751898
59protein localization to endosome (GO:0036010)3.28236014
60chaperone-mediated protein complex assembly (GO:0051131)3.27181690
61embryonic process involved in female pregnancy (GO:0060136)3.24271144
62protein localization to kinetochore (GO:0034501)3.23183439
63spindle assembly involved in mitosis (GO:0090307)3.22826556
64regulation of spindle organization (GO:0090224)3.22565125
65chromosome condensation (GO:0030261)3.21254565
66meiotic cell cycle process (GO:1903046)3.21196425
67histone H3-K9 demethylation (GO:0033169)3.20998305
68regulation of centrosome cycle (GO:0046605)3.19391535
69mitotic sister chromatid segregation (GO:0000070)3.19388807
70multicellular organism reproduction (GO:0032504)3.18669552
71regulation of NFAT protein import into nucleus (GO:0051532)3.18498273
72negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.17803337
73plasma membrane fusion (GO:0045026)3.15912328
74paraxial mesoderm development (GO:0048339)3.15508042
75meiotic cell cycle (GO:0051321)3.14954764
76histone H3-K9 methylation (GO:0051567)3.13508497
77DNA packaging (GO:0006323)3.08481586
78meiosis I (GO:0007127)3.08201993
79meiotic chromosome segregation (GO:0045132)3.07195400
80genitalia morphogenesis (GO:0035112)3.05923834
81peptidyl-lysine dimethylation (GO:0018027)3.05277896
82DNA geometric change (GO:0032392)3.04590908
83DNA duplex unwinding (GO:0032508)3.03415129
84microtubule depolymerization (GO:0007019)3.02315559
85cell-substrate junction assembly (GO:0007044)3.02267928
86protein K6-linked ubiquitination (GO:0085020)3.01627586
87regulation of chromosome segregation (GO:0051983)3.00848206
88dosage compensation (GO:0007549)2.97527776
89hemidesmosome assembly (GO:0031581)2.97489333
90mitotic metaphase plate congression (GO:0007080)2.95948600
91protein localization to chromosome (GO:0034502)2.93167014
92regulation of translational termination (GO:0006449)2.92501776
93regulation of centrosome duplication (GO:0010824)2.92165734
94microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.91860648
95mRNA stabilization (GO:0048255)2.90856107
96RNA stabilization (GO:0043489)2.90856107
97germ cell development (GO:0007281)2.89494215
98histone lysine demethylation (GO:0070076)2.88649336
99nuclear envelope organization (GO:0006998)2.87715215
100axonemal dynein complex assembly (GO:0070286)2.87691120
101nucleus organization (GO:0006997)2.86628904
102regulation of helicase activity (GO:0051095)2.85971611
103metaphase plate congression (GO:0051310)2.85602364
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83704356
105positive regulation of SMAD protein import into nucleus (GO:0060391)2.83199894
106phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.82893268
107regulation of histone H3-K27 methylation (GO:0061085)2.79268545
108peptidyl-threonine modification (GO:0018210)2.78887024
109histone demethylation (GO:0016577)2.78791810
110translesion synthesis (GO:0019985)2.78658182
111cell adhesion mediated by integrin (GO:0033627)2.75284431
112peptidyl-threonine phosphorylation (GO:0018107)2.75069041
113negative regulation of anoikis (GO:2000811)2.69761622
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.67839655
115skin morphogenesis (GO:0043589)2.65431169
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.63848641
117cell-substrate adherens junction assembly (GO:0007045)2.63256796
118focal adhesion assembly (GO:0048041)2.63256796
119cortical actin cytoskeleton organization (GO:0030866)2.59911098
120positive regulation of receptor recycling (GO:0001921)2.57285185
121negative regulation of fatty acid transport (GO:2000192)2.52402653
122positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52337013
123adherens junction assembly (GO:0034333)2.50294849
124interkinetic nuclear migration (GO:0022027)2.49323738
125regulation of necroptotic process (GO:0060544)2.44482714
126detection of molecule of bacterial origin (GO:0032490)2.42360679
127regulation of transforming growth factor beta2 production (GO:0032909)2.39943325
128stress fiber assembly (GO:0043149)2.39706320
129COPII vesicle coating (GO:0048208)2.39213892
130response to laminar fluid shear stress (GO:0034616)2.36975317
131regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36100852
132negative regulation of erythrocyte differentiation (GO:0045647)2.35825380
133pinocytosis (GO:0006907)2.33314748
134regulation of early endosome to late endosome transport (GO:2000641)2.32985765
135Golgi transport vesicle coating (GO:0048200)2.32745721
136COPI coating of Golgi vesicle (GO:0048205)2.32745721
137positive regulation of cellular response to insulin stimulus (GO:1900078)2.32723693
138positive regulation of gamma-delta T cell activation (GO:0046645)2.31329194
139iron ion import (GO:0097286)2.31118668
140corticosteroid receptor signaling pathway (GO:0031958)2.29157300
141cortical cytoskeleton organization (GO:0030865)2.28652241
142glucocorticoid receptor signaling pathway (GO:0042921)2.27918917
143protein demethylation (GO:0006482)2.25257074
144protein dealkylation (GO:0008214)2.25257074
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.24514257
146SMAD protein complex assembly (GO:0007183)2.24452387
147negative regulation of protein localization to plasma membrane (GO:1903077)2.24098062
148embryonic camera-type eye morphogenesis (GO:0048596)2.23630472
149positive regulation of protein import into nucleus, translocation (GO:0033160)2.22629150
150definitive hemopoiesis (GO:0060216)2.18176321
151positive regulation of Cdc42 GTPase activity (GO:0043089)2.16631017
152regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.15366921
153cellular response to ethanol (GO:0071361)2.14789795
154protein export from nucleus (GO:0006611)2.14064792
155membrane raft organization (GO:0031579)2.13467599
156embryonic viscerocranium morphogenesis (GO:0048703)2.13335534
157regulation of anoikis (GO:2000209)2.10712230
158phospholipid translocation (GO:0045332)2.09479548
159lipid translocation (GO:0034204)2.09479548
160positive regulation of blood vessel endothelial cell migration (GO:0043536)2.08984689
161mesodermal cell differentiation (GO:0048333)2.08713606
162activation of Rac GTPase activity (GO:0032863)2.08327234
163vesicle coating (GO:0006901)2.07692326
164hepatocyte apoptotic process (GO:0097284)2.06717465
165mammary gland epithelial cell proliferation (GO:0033598)2.06460459
166growth hormone receptor signaling pathway (GO:0060396)2.06360130
167cellular response to osmotic stress (GO:0071470)2.06077965
168cellular extravasation (GO:0045123)2.05657031
169coronary vasculature morphogenesis (GO:0060977)2.04851231
170* protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.04457755
171response to epidermal growth factor (GO:0070849)2.03571745
172platelet-derived growth factor receptor signaling pathway (GO:0048008)2.03129660
173embryonic eye morphogenesis (GO:0048048)2.02891885
174membrane protein ectodomain proteolysis (GO:0006509)2.02621046
175mRNA transcription (GO:0009299)2.00226782
176positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)1.99716956
177hippo signaling (GO:0035329)1.99674203
178positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.99573970
179positive regulation of insulin receptor signaling pathway (GO:0046628)1.99048020
180peptidyl-serine phosphorylation (GO:0018105)1.97750306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.82101412
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.68509308
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.66198161
4* SALL1_21062744_ChIP-ChIP_HESCs_Human3.95970777
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.87346368
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.60827716
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34548565
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.20465670
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17218724
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.02941368
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.88399182
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64925721
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60838314
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55587622
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44860448
16AR_21909140_ChIP-Seq_LNCAP_Human2.39786966
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30246050
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30195836
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19512712
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16411807
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16411807
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16411807
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15183468
24* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12535655
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.08543880
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05493936
27* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.00630444
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99504200
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98803088
30CLOCK_20551151_ChIP-Seq_293T_Human1.97640382
31GATA1_22025678_ChIP-Seq_K562_Human1.93333685
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83855578
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83519054
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81838867
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77861186
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77167111
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75089987
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75065152
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75065152
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73604038
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.72283980
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70102645
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69511075
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67155038
45* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63917938
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60901285
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60719769
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60013215
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57468480
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.55939001
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.54776702
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.47428655
53RUNX_20019798_ChIP-Seq_JUKART_Human1.46062478
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46037519
55PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45458410
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43919747
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42832183
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41632764
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41338643
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41028242
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40554777
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40458070
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39033955
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37771601
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37025392
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36956232
67MYC_22102868_ChIP-Seq_BL_Human1.36484417
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.35064997
69* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34397141
70TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32594097
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.30706509
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30542665
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29728752
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29178519
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27859352
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26571709
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.26439246
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.26221664
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.26221664
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.25725615
81SPI1_23127762_ChIP-Seq_K562_Human1.24641201
82* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24629246
83* PU_27001747_Chip-Seq_BMDM_Mouse1.23478981
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22798720
85* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22228154
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21893900
87TP53_16413492_ChIP-PET_HCT116_Human1.21734311
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21723237
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21691281
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20787946
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20704231
92* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20310088
93SCL_19346495_ChIP-Seq_HPC-7_Human1.18713080
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.18375028
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18197248
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17778626
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17583602
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17457745
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16631182
100VDR_24787735_ChIP-Seq_THP-1_Human1.16561034
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.16408450
102* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16396535
103* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15767652
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15113787
105MYB_26560356_Chip-Seq_TH1_Human1.14771455
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14180258
107ZNF263_19887448_ChIP-Seq_K562_Human1.13749435
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13192016
109VDR_24763502_ChIP-Seq_THP-1_Human1.11876533
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.11717596
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11022254
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10342638
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08940057
114MYC_18555785_ChIP-Seq_MESCs_Mouse1.08821271
115* KDM5A_27292631_Chip-Seq_BREAST_Human1.08586424
116TCF7_22412390_ChIP-Seq_EML_Mouse1.08435381
117VDR_21846776_ChIP-Seq_THP-1_Human1.07791876
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07357124
119TP63_19390658_ChIP-ChIP_HaCaT_Human1.06874085
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.05094348
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03847806
122GATA1_19941826_ChIP-Seq_K562_Human1.03470930
123AHR_22903824_ChIP-Seq_MCF-7_Human1.02301289
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02265375
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00862589
126GATA2_19941826_ChIP-Seq_K562_Human1.00629530
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99904186
128* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99704538
129KDM2B_26808549_Chip-Seq_K562_Human0.99428381
130MYB_26560356_Chip-Seq_TH2_Human0.99321073
131GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98135039
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97794845
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.97654227
134* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97366122
135* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96697779
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96485964
137* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96392920
138MAF_26560356_Chip-Seq_TH1_Human0.96248995
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96176305
140PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95370469
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94150132
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92676724
143CHD1_26751641_Chip-Seq_LNCaP_Human0.92273300
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92268472
145* FOXO3_23340844_ChIP-Seq_DLD1_Human0.91604588
146BRD4_25478319_ChIP-Seq_HGPS_Human0.91239976
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90582199
148MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90008085
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89521173
150NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88770882
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88466005
152HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86477710
153PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86035304
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85746844
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85236609
156KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81923068
157YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81872094
158KDM2B_26808549_Chip-Seq_DND41_Human0.80777310
159PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80538192
160SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79808851
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79662616
162* NANOG_16518401_ChIP-PET_MESCs_Mouse0.79171426
163ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77500170
164GATA6_25053715_ChIP-Seq_YYC3_Human0.76604050
165* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73592155
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73531433
167FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73385097
168EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73214683
169TCF4_18268006_ChIP-ChIP_LS174T_Human0.72901095
170NCOR1_26117541_ChIP-Seq_K562_Human0.72520290
171TFEB_21752829_ChIP-Seq_HELA_Human0.72380697
172P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72140003
173MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.71622578
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.70860405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.50257061
2MP0005410_abnormal_fertilization3.60881253
3MP0008057_abnormal_DNA_replication3.25741196
4MP0010094_abnormal_chromosome_stability3.16298054
5MP0010307_abnormal_tumor_latency2.90652854
6MP0003705_abnormal_hypodermis_morpholog2.84971453
7MP0003111_abnormal_nucleus_morphology2.84473135
8MP0010352_gastrointestinal_tract_polyps2.83844337
9MP0005076_abnormal_cell_differentiation2.67612242
10MP0003077_abnormal_cell_cycle2.52028950
11MP0001929_abnormal_gametogenesis2.51943891
12MP0005409_darkened_coat_color2.41134787
13MP0005451_abnormal_body_composition2.37379652
14MP0002210_abnormal_sex_determination2.34176234
15MP0000569_abnormal_digit_pigmentation2.30409067
16MP0004957_abnormal_blastocyst_morpholog2.28279025
17MP0001730_embryonic_growth_arrest2.25470731
18MP0005623_abnormal_meninges_morphology2.22195639
19MP0003698_abnormal_male_reproductive2.19003414
20MP0003123_paternal_imprinting2.15110997
21MP0010234_abnormal_vibrissa_follicle2.11383350
22MP0003693_abnormal_embryo_hatching2.06936506
23MP0002653_abnormal_ependyma_morphology2.02459413
24MP0002084_abnormal_developmental_patter1.99004487
25MP0001145_abnormal_male_reproductive1.98609915
26MP0008007_abnormal_cellular_replicative1.94927370
27MP0008260_abnormal_autophagy1.93139515
28MP0008058_abnormal_DNA_repair1.91629527
29MP0004197_abnormal_fetal_growth/weight/1.89052069
30MP0003121_genomic_imprinting1.88065390
31MP0005380_embryogenesis_phenotype1.84172054
32MP0001672_abnormal_embryogenesis/_devel1.84172054
33MP0003453_abnormal_keratinocyte_physiol1.83612055
34MP0000350_abnormal_cell_proliferation1.83478575
35MP0002009_preneoplasia1.82506912
36MP0005275_abnormal_skin_tensile1.80398643
37MP0003303_peritoneal_inflammation1.75590093
38MP0000653_abnormal_sex_gland1.73276263
39MP0002086_abnormal_extraembryonic_tissu1.72782396
40MP0003984_embryonic_growth_retardation1.70687009
41MP0002085_abnormal_embryonic_tissue1.69288252
42MP0002088_abnormal_embryonic_growth/wei1.68556809
43MP0002396_abnormal_hematopoietic_system1.68205275
44MP0003787_abnormal_imprinting1.66371382
45MP0001697_abnormal_embryo_size1.64593567
46MP0003890_abnormal_embryonic-extraembry1.60562203
47MP0003191_abnormal_cellular_cholesterol1.57763364
48MP0002166_altered_tumor_susceptibility1.57309252
49MP0003828_pulmonary_edema1.56235437
50MP0003566_abnormal_cell_adhesion1.54939589
51MP0003763_abnormal_thymus_physiology1.51325919
52MP0000537_abnormal_urethra_morphology1.49696580
53MP0010368_abnormal_lymphatic_system1.48435972
54MP0001958_emphysema1.45736498
55MP0004185_abnormal_adipocyte_glucose1.44246657
56MP0002161_abnormal_fertility/fecundity1.38007578
57MP0004264_abnormal_extraembryonic_tissu1.37962462
58MP0004947_skin_inflammation1.35813221
59MP0000733_abnormal_muscle_development1.34801407
60MP0001849_ear_inflammation1.34301015
61MP0002877_abnormal_melanocyte_morpholog1.31514478
62MP0002080_prenatal_lethality1.31493520
63MP0001293_anophthalmia1.30418476
64MP0003786_premature_aging1.28962781
65MP0002060_abnormal_skin_morphology1.28382737
66MP0003656_abnormal_erythrocyte_physiolo1.24658220
67MP0003937_abnormal_limbs/digits/tail_de1.23599920
68MP0002006_tumorigenesis1.22777278
69MP0009703_decreased_birth_body1.22491376
70MP0001915_intracranial_hemorrhage1.19463793
71MP0003941_abnormal_skin_development1.16535591
72MP0001835_abnormal_antigen_presentation1.14863770
73MP0008932_abnormal_embryonic_tissue1.14362182
74MP0009053_abnormal_anal_canal1.13658181
75MP0000767_abnormal_smooth_muscle1.13419779
76MP0002796_impaired_skin_barrier1.12927207
77MP0003436_decreased_susceptibility_to1.09772131
78MP0005058_abnormal_lysosome_morphology1.09349682
79MP0009672_abnormal_birth_weight1.08595917
80MP0003091_abnormal_cell_migration1.08215581
81MP0004808_abnormal_hematopoietic_stem1.07604925
82MP0003567_abnormal_fetal_cardiomyocyte1.07054191
83MP0002998_abnormal_bone_remodeling1.06987637
84MP0006054_spinal_hemorrhage1.04154762
85MP0002697_abnormal_eye_size1.03700489
86MP0000858_altered_metastatic_potential1.03527369
87MP0003448_altered_tumor_morphology1.02846808
88MP0003119_abnormal_digestive_system1.02233815
89MP0003950_abnormal_plasma_membrane1.01962160
90MP0003115_abnormal_respiratory_system1.01692609
91MP0002092_abnormal_eye_morphology1.01659924
92MP0000428_abnormal_craniofacial_morphol1.01552740
93MP0009278_abnormal_bone_marrow1.00220403
94MP0003221_abnormal_cardiomyocyte_apopto0.99134441
95MP0002925_abnormal_cardiovascular_devel0.98456940
96MP0000432_abnormal_head_morphology0.98318371
97MP0005464_abnormal_platelet_physiology0.96781196
98MP0005666_abnormal_adipose_tissue0.96623922
99MP0008995_early_reproductive_senescence0.96149828
100MP0005023_abnormal_wound_healing0.95923764
101MP0004233_abnormal_muscle_weight0.94095103
102MP0002896_abnormal_bone_mineralization0.93901508
103MP0001851_eye_inflammation0.92723025
104MP0003935_abnormal_craniofacial_develop0.92143837
105MP0003172_abnormal_lysosome_physiology0.90972669
106MP0003183_abnormal_peptide_metabolism0.90068150
107MP0001216_abnormal_epidermal_layer0.89662304
108MP0010678_abnormal_skin_adnexa0.87987885
109MP0003868_abnormal_feces_composition0.87323611
110MP0005248_abnormal_Harderian_gland0.84280317
111MP0003279_aneurysm0.83809178
112MP0000313_abnormal_cell_death0.83221576
113MP0008438_abnormal_cutaneous_collagen0.82455531
114MP0000427_abnormal_hair_cycle0.82354435
115MP0001661_extended_life_span0.82106505
116MP0003861_abnormal_nervous_system0.82044777
117MP0003300_gastrointestinal_ulcer0.81903369
118MP0004272_abnormal_basement_membrane0.80590535
119MP0000383_abnormal_hair_follicle0.80349112
120MP0001879_abnormal_lymphatic_vessel0.79870778
121MP0003878_abnormal_ear_physiology0.78958334
122MP0005377_hearing/vestibular/ear_phenot0.78958334
123MP0002160_abnormal_reproductive_system0.78430049
124MP0005164_abnormal_response_to0.78395660
125MP0005621_abnormal_cell_physiology0.78315593
126MP0005187_abnormal_penis_morphology0.76987859
127MP0009115_abnormal_fat_cell0.76163604
128MP0003699_abnormal_female_reproductive0.75212305
129MP0003936_abnormal_reproductive_system0.74757756
130MP0004087_abnormal_muscle_fiber0.74114726
131MP0001119_abnormal_female_reproductive0.74088882
132MP0008004_abnormal_stomach_pH0.73159455
133MP0000685_abnormal_immune_system0.72971182
134MP0003045_fibrosis0.71796115
135MP0000703_abnormal_thymus_morphology0.71465683
136MP0002419_abnormal_innate_immunity0.71082413
137MP0002019_abnormal_tumor_incidence0.70985079
138MP0004084_abnormal_cardiac_muscle0.70945770
139MP0005310_abnormal_salivary_gland0.70736479
140MP0000759_abnormal_skeletal_muscle0.70524897
141MP0004036_abnormal_muscle_relaxation0.70232682
142MP0002398_abnormal_bone_marrow0.70066068
143MP0000266_abnormal_heart_morphology0.69347354
144MP0005384_cellular_phenotype0.68534070
145MP0002405_respiratory_system_inflammati0.68326507
146MP0002971_abnormal_brown_adipose0.67315359
147MP0000627_abnormal_mammary_gland0.67294224
148MP0005257_abnormal_intraocular_pressure0.66842359
149MP0004381_abnormal_hair_follicle0.66421121
150MP0001784_abnormal_fluid_regulation0.66074795
151MP0000377_abnormal_hair_follicle0.66015825
152MP0010630_abnormal_cardiac_muscle0.65338469
153MP0003755_abnormal_palate_morphology0.65041775
154MP0005367_renal/urinary_system_phenotyp0.65003171
155MP0000516_abnormal_urinary_system0.65003171
156MP0002282_abnormal_trachea_morphology0.64759242
157MP0005375_adipose_tissue_phenotype0.63040049
158MP0005397_hematopoietic_system_phenotyp0.62689606

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77349755
2Abnormality of the lower motor neuron (HP:0002366)3.82458573
3Absent/shortened dynein arms (HP:0200106)3.66719114
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.66719114
5Ependymoma (HP:0002888)3.66147847
6Abnormality of the astrocytes (HP:0100707)3.33461338
7Astrocytoma (HP:0009592)3.33461338
8Heterotopia (HP:0002282)3.18405199
9Osteolytic defects of the phalanges of the hand (HP:0009771)2.94858906
10Osteolytic defects of the hand bones (HP:0009699)2.94858906
11Papillary thyroid carcinoma (HP:0002895)2.94183231
12Volvulus (HP:0002580)2.93474261
13Neoplasm of the oral cavity (HP:0100649)2.84821264
14Arterial tortuosity (HP:0005116)2.83320849
15Selective tooth agenesis (HP:0001592)2.80893370
16Protrusio acetabuli (HP:0003179)2.75163851
17Abnormal respiratory motile cilium physiology (HP:0012261)2.74932285
18Medulloblastoma (HP:0002885)2.72116037
19Biliary tract neoplasm (HP:0100574)2.71085450
20Male infertility (HP:0003251)2.66837963
21Chronic bronchitis (HP:0004469)2.65859946
22Impulsivity (HP:0100710)2.62782090
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61810910
24Vascular tortuosity (HP:0004948)2.61558926
25Flat acetabular roof (HP:0003180)2.61517888
26Spinal cord lesions (HP:0100561)2.60329447
27Syringomyelia (HP:0003396)2.60329447
28Glioma (HP:0009733)2.60126692
29Abnormality of the labia minora (HP:0012880)2.55905847
30Rhinitis (HP:0012384)2.52265667
31Aortic aneurysm (HP:0004942)2.48385444
32Sandal gap (HP:0001852)2.47253899
33Chromsome breakage (HP:0040012)2.45248494
34Premature rupture of membranes (HP:0001788)2.44735172
35Ectopic kidney (HP:0000086)2.43029422
36Vertebral arch anomaly (HP:0008438)2.42687667
37Rhabdomyosarcoma (HP:0002859)2.40684301
38Missing ribs (HP:0000921)2.36657925
39Short 4th metacarpal (HP:0010044)2.36478572
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36478572
41Prominent nose (HP:0000448)2.35963539
42Infertility (HP:0000789)2.35892596
43Aortic dissection (HP:0002647)2.35121643
44Ankyloglossia (HP:0010296)2.33074233
45Absent frontal sinuses (HP:0002688)2.33025863
46Hypopigmentation of the fundus (HP:0007894)2.31108041
47Upper motor neuron abnormality (HP:0002127)2.30721590
48Overgrowth (HP:0001548)2.27693973
49Truncal obesity (HP:0001956)2.25598410
50Deviation of the thumb (HP:0009603)2.24100192
51Dislocated radial head (HP:0003083)2.24057934
52Mitral valve prolapse (HP:0001634)2.23656518
53Neoplasm of striated muscle (HP:0009728)2.21503346
54Increased nuchal translucency (HP:0010880)2.19000034
55Abnormality of the fingertips (HP:0001211)2.18965251
56Deep philtrum (HP:0002002)2.15605049
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15223960
58Amyotrophic lateral sclerosis (HP:0007354)2.14224937
59Abnormality of chromosome stability (HP:0003220)2.13503889
60Proximal placement of thumb (HP:0009623)2.12955411
61Spondylolisthesis (HP:0003302)2.11151254
62Asymmetry of the thorax (HP:0001555)2.10901981
63Nasal polyposis (HP:0100582)2.10135203
64Dilatation of the ascending aorta (HP:0005111)2.09803499
65Gonadotropin excess (HP:0000837)2.09470401
66Broad face (HP:0000283)2.08752367
67Abnormal spermatogenesis (HP:0008669)2.08241128
68Dysmetric saccades (HP:0000641)2.07906192
69Subacute progressive viral hepatitis (HP:0006572)2.07339988
70Malignant gastrointestinal tract tumors (HP:0006749)2.06677397
71Gastrointestinal carcinoma (HP:0002672)2.06677397
72Abnormality of oral frenula (HP:0000190)2.06078210
73Increased connective tissue (HP:0009025)2.05950821
74Short humerus (HP:0005792)2.04856212
75Wormian bones (HP:0002645)2.03385774
76Renovascular hypertension (HP:0100817)2.02718050
7711 pairs of ribs (HP:0000878)2.02344277
78Abnormal respiratory motile cilium morphology (HP:0005938)2.01998281
79Abnormal respiratory epithelium morphology (HP:0012253)2.01998281
80Cerebral aneurysm (HP:0004944)1.99803356
81Atrophic scars (HP:0001075)1.98528909
82Ankle contracture (HP:0006466)1.97805160
83Short nail (HP:0001799)1.96746281
84Abnormality of the radial head (HP:0003995)1.96415053
85Hand muscle atrophy (HP:0009130)1.95919595
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.94411425
87Hypoplastic labia majora (HP:0000059)1.91121820
88Insidious onset (HP:0003587)1.90614394
89Termporal pattern (HP:0011008)1.90614394
90Periodontitis (HP:0000704)1.89988843
91Acute myeloid leukemia (HP:0004808)1.89982089
92Azoospermia (HP:0000027)1.89629829
93High pitched voice (HP:0001620)1.89308321
94Peritonitis (HP:0002586)1.89035197
95Aneurysm (HP:0002617)1.88751868
96Eczematoid dermatitis (HP:0000976)1.87990173
97Agnosia (HP:0010524)1.86559569
98Supernumerary ribs (HP:0005815)1.86503672
99Degeneration of anterior horn cells (HP:0002398)1.84121093
100Abnormality of the anterior horn cell (HP:0006802)1.84121093
101Relative macrocephaly (HP:0004482)1.84038063
102Shallow orbits (HP:0000586)1.84037194
103Long eyelashes (HP:0000527)1.83762326
104Supernumerary spleens (HP:0009799)1.83454697
105Spontaneous hematomas (HP:0007420)1.83132386
106Aplasia/hypoplasia of the humerus (HP:0006507)1.82390274
107Facial hemangioma (HP:0000329)1.82148009
108Skull defect (HP:0001362)1.82061301
109Narrow palate (HP:0000189)1.80740158
110Viral hepatitis (HP:0006562)1.80375748
111Hypoplastic ischia (HP:0003175)1.80214428
112Metaphyseal cupping (HP:0003021)1.80115879
113Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79279400
114Gingivitis (HP:0000230)1.79055537
115Uterine leiomyosarcoma (HP:0002891)1.78949404
116Leiomyosarcoma (HP:0100243)1.78949404
117Colon cancer (HP:0003003)1.77501343
118Abnormality of the 4th metacarpal (HP:0010012)1.77224025
119Breast carcinoma (HP:0003002)1.77167673
120Cerebral inclusion bodies (HP:0100314)1.76079118
121Esophageal varix (HP:0002040)1.75295787
122Cafe-au-lait spot (HP:0000957)1.74947109
123Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74342543
124Cortical dysplasia (HP:0002539)1.74082413
125Mitral stenosis (HP:0001718)1.73347310
126Low anterior hairline (HP:0000294)1.73286199
127Short ribs (HP:0000773)1.72744278
128Coarse hair (HP:0002208)1.71698845
129Transitional cell carcinoma of the bladder (HP:0006740)1.71646734
130Abnormality of the labia majora (HP:0012881)1.71516508
131Broad thumb (HP:0011304)1.71354096
132Nephronophthisis (HP:0000090)1.70496998
133Abnormal ciliary motility (HP:0012262)1.70065880
134Myocardial infarction (HP:0001658)1.70036458
135Thin bony cortex (HP:0002753)1.69274015
136Hyperacusis (HP:0010780)1.69222716
137Basal cell carcinoma (HP:0002671)1.68792405
138Distal lower limb amyotrophy (HP:0008944)1.68775619
139Urethral obstruction (HP:0000796)1.68565353
140Bladder neoplasm (HP:0009725)1.67458472
141Bladder carcinoma (HP:0002862)1.67458472
142Disproportionate tall stature (HP:0001519)1.67000724
143Cubitus valgus (HP:0002967)1.66967566
144Persistence of primary teeth (HP:0006335)1.65696502
145Fibular hypoplasia (HP:0003038)1.65689905
146Tubular atrophy (HP:0000092)1.65377603
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.65171255
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64908585
149Upper limb amyotrophy (HP:0009129)1.64581033
150Distal upper limb amyotrophy (HP:0007149)1.64581033
151Macroorchidism (HP:0000053)1.64150013
152Abnormality of the carotid arteries (HP:0005344)1.64115450
153Vertebral compression fractures (HP:0002953)1.62222764
154Oligodactyly (HP:0012165)1.62077278
155Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.61845522
156Shawl scrotum (HP:0000049)1.61644175
157Oligodactyly (hands) (HP:0001180)1.61641727
158Joint laxity (HP:0001388)1.61594880
159Menstrual irregularities (HP:0000858)1.61095038
160Neonatal hypoglycemia (HP:0001998)1.60236094
161Pseudobulbar signs (HP:0002200)1.59449413
162Pelvic girdle muscle weakness (HP:0003749)1.59308293
163Thoracolumbar scoliosis (HP:0002944)1.58991958
164Advanced eruption of teeth (HP:0006288)1.58603518
165Subaortic stenosis (HP:0001682)1.58473267
166Abnormality of the left ventricular outflow tract (HP:0011103)1.58473267
167Abnormality of the nasal mucosa (HP:0000433)1.58373631
168Ulnar bowing (HP:0003031)1.57905818
169Conjunctival telangiectasia (HP:0000524)1.57898370
170Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.57720741
171T lymphocytopenia (HP:0005403)1.56249507
172Thyroid carcinoma (HP:0002890)1.55276696
173Slow saccadic eye movements (HP:0000514)1.55208514
174Cellulitis (HP:0100658)1.54505296
175Difficulty running (HP:0009046)1.54097347
176Increased variability in muscle fiber diameter (HP:0003557)1.53853728
177Mitral regurgitation (HP:0001653)1.52216887
178Renal cell carcinoma (HP:0005584)1.49738682
179Abnormal foot bone ossification (HP:0010675)1.49690760
180Colitis (HP:0002583)1.49595627
181Abnormality of skeletal muscle fiber size (HP:0012084)1.49165477
182Recurrent bacterial skin infections (HP:0005406)1.49083641
183Resting tremor (HP:0002322)1.48935626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.91964257
2PDK33.86551478
3PDK43.86551478
4CDC73.54673615
5LATS13.36834467
6NEK22.81674824
7PRPF4B2.74481292
8PDK22.35163313
9PNCK2.34041023
10STK32.10967813
11TTK2.09280708
12ICK2.07700003
13EEF2K2.02437584
14PRKD31.95984162
15BRD41.95276788
16NEK91.94433922
17PKN21.74689158
18MAP3K131.72009791
19WEE11.70341873
20MAP3K141.65154276
21EPHA21.63868979
22SMG11.56000564
23TYRO31.54588749
24AKT31.51871272
25CAMK1D1.47880386
26STK38L1.46876302
27LATS21.46431809
28MAP3K21.44730612
29SCYL21.43687707
30MAP2K31.42016614
31MTOR1.41413537
32MST1R1.37937883
33TRPM71.36841400
34ATR1.33216747
35CAMK1G1.33130477
36JAK11.32194556
37* CHEK11.31693327
38CHEK21.26264228
39NEK11.24759600
40ATM1.21494624
41RPS6KB21.18171786
42CDK61.17956099
43TRIB31.14946462
44JAK31.14087446
45PLK11.13006621
46RIPK11.12144203
47CDK41.11509869
48IRAK31.11020146
49FGR1.10471345
50TTN1.09019820
51PLK41.08748883
52STK101.07584366
53STK241.07579326
54RIPK41.06666938
55PDGFRA1.06207881
56CSK1.06064430
57SGK21.05997636
58MAP3K101.05709949
59TESK11.04042373
60ALK1.00883309
61ERN11.00464123
62CDK90.98782004
63TGFBR20.96925925
64MELK0.96573797
65TYK20.96431251
66PASK0.96003700
67SRPK10.94714561
68MARK20.94262605
69MET0.91580458
70YES10.89954555
71CDK70.89811732
72WNK10.89138442
73STK380.88366503
74MOS0.86218303
75PTK60.85539417
76ACVR1B0.84052464
77CDK20.83827814
78AURKB0.83403192
79CSNK1D0.82698033
80PIK3CG0.82193160
81ZAP700.81544046
82MAP3K30.81295304
83PDGFRB0.80599749
84STK40.79975637
85MAP3K80.79176140
86PLK30.79089427
87FGFR20.77989990
88MAP3K90.77835230
89NEK60.77248096
90MAP3K10.76182225
91CDC42BPA0.74696339
92FGFR10.74409823
93EPHB10.71285171
94SIK10.69426323
95ERBB40.68806895
96CDK10.68682965
97TSSK60.67511501
98NLK0.66066222
99BMPR20.64143731
100PTK2B0.64142437
101BLK0.63521033
102PAK20.63510538
103PDPK10.62419612
104FGFR30.61440007
105BMX0.61342696
106MAP3K70.60727036
107PAK40.60003338
108RET0.57835060
109CSF1R0.56807079
110PRKDC0.55421312
111PDK10.53417591
112DYRK30.53289990
113MAPK110.53022831
114JAK20.51581859
115DDR20.50391494
116FRK0.49484960
117LMTK20.49217164
118BRSK20.48788367
119RAF10.47722275
120NTRK10.46751186
121CSNK1E0.46702137
122MAPK140.45861659
123BTK0.45861049
124MARK30.44640316
125RPS6KB10.44640236
126MAPK100.44615006
127GSK3B0.44374513
128WNK30.44078013
129IKBKE0.43690266
130HCK0.43572703
131KSR20.43484454
132SGK4940.43274630
133SGK2230.43274630
134KSR10.43020277
135PAK60.42751727
136LRRK20.42010355
137PIM10.40985708
138DMPK0.40859594
139NUAK10.40700623
140MAP3K40.40266591
141MAPK10.39972342
142CHUK0.39034192
143PTK20.38478026
144PRKAA20.37289871
145PRKAA10.36579445
146MAP3K60.34264484
147FER0.33562967
148FLT30.33361471
149AKT10.32309833
150MAPK80.30854571
151FGFR40.30491616
152SGK30.30098570
153RPS6KA40.29173494
154EGFR0.27708761

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.70724450
2Cell cycle_Homo sapiens_hsa041102.52630363
3mRNA surveillance pathway_Homo sapiens_hsa030152.38986461
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32622874
5Fanconi anemia pathway_Homo sapiens_hsa034602.15106421
6Dorso-ventral axis formation_Homo sapiens_hsa043202.11207306
7* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.93662253
8Basal transcription factors_Homo sapiens_hsa030221.89187702
9Adherens junction_Homo sapiens_hsa045201.76961775
10Mismatch repair_Homo sapiens_hsa034301.74772287
11Lysine degradation_Homo sapiens_hsa003101.70099600
12MicroRNAs in cancer_Homo sapiens_hsa052061.70039882
13Oocyte meiosis_Homo sapiens_hsa041141.70000923
14One carbon pool by folate_Homo sapiens_hsa006701.67266577
15Non-homologous end-joining_Homo sapiens_hsa034501.65576805
16B cell receptor signaling pathway_Homo sapiens_hsa046621.63386727
17Selenocompound metabolism_Homo sapiens_hsa004501.58624231
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.56273349
19mTOR signaling pathway_Homo sapiens_hsa041501.54961260
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53394101
21Systemic lupus erythematosus_Homo sapiens_hsa053221.52130701
22Viral carcinogenesis_Homo sapiens_hsa052031.50159663
23p53 signaling pathway_Homo sapiens_hsa041151.47717882
24Spliceosome_Homo sapiens_hsa030401.45899614
25RNA degradation_Homo sapiens_hsa030181.41233896
26TGF-beta signaling pathway_Homo sapiens_hsa043501.40322594
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39540567
28Small cell lung cancer_Homo sapiens_hsa052221.38965218
29Hippo signaling pathway_Homo sapiens_hsa043901.38248951
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37938574
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31401358
32DNA replication_Homo sapiens_hsa030301.28574510
33Antigen processing and presentation_Homo sapiens_hsa046121.28250040
34Osteoclast differentiation_Homo sapiens_hsa043801.27764981
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26505412
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.26496251
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25172929
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22566181
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.21322421
40Homologous recombination_Homo sapiens_hsa034401.20043966
41Measles_Homo sapiens_hsa051621.17790328
42T cell receptor signaling pathway_Homo sapiens_hsa046601.16279396
43Basal cell carcinoma_Homo sapiens_hsa052171.15640167
44Leishmaniasis_Homo sapiens_hsa051401.09939857
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09772305
46Proteoglycans in cancer_Homo sapiens_hsa052051.09683434
47Tight junction_Homo sapiens_hsa045301.09196768
48HTLV-I infection_Homo sapiens_hsa051661.09092986
49Glucagon signaling pathway_Homo sapiens_hsa049221.08797286
50Chronic myeloid leukemia_Homo sapiens_hsa052201.08550033
51Nucleotide excision repair_Homo sapiens_hsa034201.07448171
52Hepatitis C_Homo sapiens_hsa051601.07248579
53TNF signaling pathway_Homo sapiens_hsa046681.06656567
54Platelet activation_Homo sapiens_hsa046111.05998941
55Colorectal cancer_Homo sapiens_hsa052101.05558407
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04550015
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.01993445
58Prostate cancer_Homo sapiens_hsa052151.01744452
59Focal adhesion_Homo sapiens_hsa045101.01554969
60Endometrial cancer_Homo sapiens_hsa052131.01264535
61Notch signaling pathway_Homo sapiens_hsa043301.00783455
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00131303
63Fatty acid biosynthesis_Homo sapiens_hsa000610.98734440
64ECM-receptor interaction_Homo sapiens_hsa045120.96326966
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95550950
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.95447196
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95367314
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.92935125
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92914744
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.92561676
71Apoptosis_Homo sapiens_hsa042100.90506058
72GnRH signaling pathway_Homo sapiens_hsa049120.86976651
73Vitamin B6 metabolism_Homo sapiens_hsa007500.86967429
74Pancreatic cancer_Homo sapiens_hsa052120.86696115
75Hedgehog signaling pathway_Homo sapiens_hsa043400.86214537
76Herpes simplex infection_Homo sapiens_hsa051680.85901567
77AMPK signaling pathway_Homo sapiens_hsa041520.85739457
78Renal cell carcinoma_Homo sapiens_hsa052110.85131699
79Shigellosis_Homo sapiens_hsa051310.82275622
80Thyroid cancer_Homo sapiens_hsa052160.81756080
81Malaria_Homo sapiens_hsa051440.80632427
82Viral myocarditis_Homo sapiens_hsa054160.80205228
83Epstein-Barr virus infection_Homo sapiens_hsa051690.80029829
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.79999424
85Other glycan degradation_Homo sapiens_hsa005110.79098662
86Chemokine signaling pathway_Homo sapiens_hsa040620.78358677
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78160163
88Wnt signaling pathway_Homo sapiens_hsa043100.77823450
89Tuberculosis_Homo sapiens_hsa051520.77759182
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77658321
91FoxO signaling pathway_Homo sapiens_hsa040680.76569953
92Nitrogen metabolism_Homo sapiens_hsa009100.76454674
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76435016
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76131655
95Estrogen signaling pathway_Homo sapiens_hsa049150.75950049
96Prion diseases_Homo sapiens_hsa050200.73299107
97Long-term potentiation_Homo sapiens_hsa047200.73231694
98Pathways in cancer_Homo sapiens_hsa052000.72562335
99Inositol phosphate metabolism_Homo sapiens_hsa005620.72518315
100Base excision repair_Homo sapiens_hsa034100.72341859
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72338100
102Pentose phosphate pathway_Homo sapiens_hsa000300.71048213
103Insulin resistance_Homo sapiens_hsa049310.70590789
104Non-small cell lung cancer_Homo sapiens_hsa052230.69287855
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67338235
106Alcoholism_Homo sapiens_hsa050340.67185116
107HIF-1 signaling pathway_Homo sapiens_hsa040660.65787189
108VEGF signaling pathway_Homo sapiens_hsa043700.64358005
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64254959
110Toxoplasmosis_Homo sapiens_hsa051450.63448404
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62715301
112Salmonella infection_Homo sapiens_hsa051320.61950202
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61839032
114Glioma_Homo sapiens_hsa052140.61396215
115Rap1 signaling pathway_Homo sapiens_hsa040150.60337746
116Type II diabetes mellitus_Homo sapiens_hsa049300.57703765
117Gap junction_Homo sapiens_hsa045400.55338032
118Influenza A_Homo sapiens_hsa051640.54581954
119Amoebiasis_Homo sapiens_hsa051460.54345018
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.52744006
121Bladder cancer_Homo sapiens_hsa052190.52470275
122Prolactin signaling pathway_Homo sapiens_hsa049170.51947892
123Biosynthesis of amino acids_Homo sapiens_hsa012300.50802168
124Hepatitis B_Homo sapiens_hsa051610.49921707
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49453791
126Insulin signaling pathway_Homo sapiens_hsa049100.49365993
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48276779
128ErbB signaling pathway_Homo sapiens_hsa040120.47497505
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.46042544
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44784648
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44068416
132Pyruvate metabolism_Homo sapiens_hsa006200.43616694
133Acute myeloid leukemia_Homo sapiens_hsa052210.43316814
134Endocytosis_Homo sapiens_hsa041440.42842726
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42826233
136Choline metabolism in cancer_Homo sapiens_hsa052310.41915866
137Melanoma_Homo sapiens_hsa052180.41469037

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