TRIP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.70155340
2muscle filament sliding (GO:0030049)5.54461043
3actin-myosin filament sliding (GO:0033275)5.54461043
4plasma membrane repair (GO:0001778)5.27258239
5regulation of vitamin D biosynthetic process (GO:0060556)5.17955516
6positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.87457062
7regulation of skeletal muscle contraction (GO:0014819)4.80534436
8regulation of membrane protein ectodomain proteolysis (GO:0051043)4.59899762
9actin-mediated cell contraction (GO:0070252)4.59796590
10cardiac myofibril assembly (GO:0055003)4.31803726
11myofibril assembly (GO:0030239)4.31235371
12regulation of vitamin metabolic process (GO:0030656)4.26600819
13regulation of cytokine secretion involved in immune response (GO:0002739)4.15168161
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.08490490
15skeletal muscle adaptation (GO:0043501)4.04205249
16activation of MAPKKK activity (GO:0000185)3.99882209
17cardiac muscle cell development (GO:0055013)3.91467015
18epithelial cell-cell adhesion (GO:0090136)3.80187199
19actomyosin structure organization (GO:0031032)3.73757380
20virion attachment to host cell (GO:0019062)3.73348885
21adhesion of symbiont to host cell (GO:0044650)3.73348885
22cardiac cell development (GO:0055006)3.72313991
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.68033535
24regulation of podosome assembly (GO:0071801)3.62618359
25actin filament-based movement (GO:0030048)3.60621908
26regulation of chronic inflammatory response (GO:0002676)3.60127526
27positive regulation of chemokine biosynthetic process (GO:0045080)3.58719780
28branching involved in labyrinthine layer morphogenesis (GO:0060670)3.54446532
29positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50741976
30regulation of T-helper 1 cell differentiation (GO:0045625)3.49432047
31adhesion of symbiont to host (GO:0044406)3.49083865
32negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.47213280
33tricarboxylic acid cycle (GO:0006099)3.44353800
34NIK/NF-kappaB signaling (GO:0038061)3.37741058
35protein localization to endosome (GO:0036010)3.35854369
36negative regulation of potassium ion transmembrane transport (GO:1901380)3.32380522
37positive regulation of heat generation (GO:0031652)3.27582890
38striated muscle atrophy (GO:0014891)3.25018622
39carnitine shuttle (GO:0006853)3.23439994
40apoptotic process involved in morphogenesis (GO:0060561)3.20954795
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20878776
42regulation of chemokine biosynthetic process (GO:0045073)3.20169945
43skeletal muscle contraction (GO:0003009)3.18368492
44regulation of gene silencing by RNA (GO:0060966)3.16337830
45regulation of posttranscriptional gene silencing (GO:0060147)3.16337830
46regulation of gene silencing by miRNA (GO:0060964)3.16337830
47IMP metabolic process (GO:0046040)3.15167966
48IMP biosynthetic process (GO:0006188)3.13860958
49pinocytosis (GO:0006907)3.11818445
50regulation of fever generation (GO:0031620)3.11562493
51paraxial mesoderm development (GO:0048339)3.09203723
52heart trabecula formation (GO:0060347)3.09052851
53negative regulation of nitric oxide biosynthetic process (GO:0045019)3.08774399
54barbed-end actin filament capping (GO:0051016)3.06212772
55positive regulation of Cdc42 GTPase activity (GO:0043089)3.05748241
56cell-substrate junction assembly (GO:0007044)3.04318383
57cardiac muscle tissue morphogenesis (GO:0055008)3.01329175
58positive regulation of SMAD protein import into nucleus (GO:0060391)2.99053809
59regulation of early endosome to late endosome transport (GO:2000641)2.97790726
60regulation of SMAD protein import into nucleus (GO:0060390)2.95917462
61regulation of mononuclear cell migration (GO:0071675)2.95516658
62hemidesmosome assembly (GO:0031581)2.95474042
63cardiac muscle contraction (GO:0060048)2.91716671
64germinal center formation (GO:0002467)2.91552715
65cell adhesion mediated by integrin (GO:0033627)2.91387489
66myeloid dendritic cell differentiation (GO:0043011)2.90105781
67fatty acid transmembrane transport (GO:1902001)2.89942945
68regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87668051
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87498226
70regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.87284556
71vascular endothelial growth factor signaling pathway (GO:0038084)2.86792936
72striated muscle contraction (GO:0006941)2.86487963
73T-helper 1 type immune response (GO:0042088)2.86387739
74regulation of tight junction assembly (GO:2000810)2.85136800
75regulation of p38MAPK cascade (GO:1900744)2.84704323
76response to muscle activity (GO:0014850)2.84517556
77muscle tissue morphogenesis (GO:0060415)2.83387726
78ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.80403213
79positive regulation of endothelial cell apoptotic process (GO:2000353)2.80071196
80regulation of cholesterol storage (GO:0010885)2.79520580
81wound healing, spreading of epidermal cells (GO:0035313)2.76898983
82regulation of interferon-alpha production (GO:0032647)2.76630685
83desmosome organization (GO:0002934)2.75711297
84creatine metabolic process (GO:0006600)2.74228217
85glycosphingolipid catabolic process (GO:0046479)2.73359090
86focal adhesion assembly (GO:0048041)2.71889730
87cell-substrate adherens junction assembly (GO:0007045)2.71889730
88regulation of heterotypic cell-cell adhesion (GO:0034114)2.71524675
89regulation of hippo signaling (GO:0035330)2.71516586
90sarcoplasmic reticulum calcium ion transport (GO:0070296)2.71348858
91positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69696949
92basement membrane organization (GO:0071711)2.68652852
93type I interferon signaling pathway (GO:0060337)2.68012943
94cellular response to type I interferon (GO:0071357)2.68012943
95response to inactivity (GO:0014854)2.67783982
96regulation of necroptotic process (GO:0060544)2.67260574
97ventricular cardiac muscle cell development (GO:0055015)2.66868167
98adherens junction assembly (GO:0034333)2.66263742
99stress fiber assembly (GO:0043149)2.65839718
100regulation of nitric oxide biosynthetic process (GO:0045428)2.65412093
101regulation of immunoglobulin secretion (GO:0051023)2.65299305
102response to type I interferon (GO:0034340)2.64961432
103protein hydroxylation (GO:0018126)2.64422179
104decidualization (GO:0046697)2.64114731
105response to peptidoglycan (GO:0032494)2.60426806
106NADH metabolic process (GO:0006734)2.58478681
107regulation of integrin activation (GO:0033623)2.56308529
108negative regulation of necroptotic process (GO:0060546)2.54608139
109cellular response to virus (GO:0098586)2.54226815
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54100729
111positive regulation of lipid storage (GO:0010884)2.53983418
112negative regulation of lipid storage (GO:0010888)2.52766283
113regulation of actin filament-based movement (GO:1903115)2.51782815
114regulation of NFAT protein import into nucleus (GO:0051532)2.51031270
115regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50929249
116ventricular cardiac muscle cell action potential (GO:0086005)2.50393969
117oligosaccharide catabolic process (GO:0009313)2.50220946
118endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49828565
119positive regulation of nitric oxide biosynthetic process (GO:0045429)2.49637825
120modulation by symbiont of host cellular process (GO:0044068)2.49190969
121protein heterotrimerization (GO:0070208)2.49144023
122cellular response to thyroid hormone stimulus (GO:0097067)2.48489760
123negative regulation of interleukin-12 production (GO:0032695)2.48285347
124endocytic recycling (GO:0032456)2.46860995
125negative regulation of cell size (GO:0045792)2.46832624
126skeletal muscle tissue regeneration (GO:0043403)2.46662106
127regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46497270
128positive regulation of myotube differentiation (GO:0010831)2.45948037
129regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45931684
130low-density lipoprotein particle clearance (GO:0034383)2.45121952
131striated muscle cell development (GO:0055002)2.44912730
132positive regulation of p38MAPK cascade (GO:1900745)2.43994823
133negative regulation of cytokine production involved in immune response (GO:0002719)2.43154836
134regulation of relaxation of muscle (GO:1901077)2.43092105
135muscle atrophy (GO:0014889)2.42256425
136fructose metabolic process (GO:0006000)2.41378420
137trophoblast giant cell differentiation (GO:0060707)2.41285345
138peptidyl-proline hydroxylation (GO:0019511)2.40754305
139regulation of coenzyme metabolic process (GO:0051196)2.40187373
140regulation of cofactor metabolic process (GO:0051193)2.40187373
141endodermal cell differentiation (GO:0035987)2.40131178
142cellular response to lipopolysaccharide (GO:0071222)2.39897499
143folic acid-containing compound biosynthetic process (GO:0009396)2.39789685
144regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.38559023
145cellular response to nicotine (GO:0071316)2.38480662
146chronic inflammatory response (GO:0002544)2.38415601
147glycolipid catabolic process (GO:0019377)2.37979760
148maternal placenta development (GO:0001893)2.36444791
149positive regulation of transcription factor import into nucleus (GO:0042993)2.35905479
150apoptotic cell clearance (GO:0043277)2.35631507
151mRNA transcription (GO:0009299)2.35564362
152heart process (GO:0003015)2.35211659
153heart contraction (GO:0060047)2.35211659
154regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.34956824
155negative regulation of heart growth (GO:0061117)2.34944537
156negative regulation of cardiac muscle tissue growth (GO:0055022)2.34944537
157striated muscle adaptation (GO:0014888)2.34448531
158muscle contraction (GO:0006936)2.34126447
159trabecula morphogenesis (GO:0061383)2.34056960
160regulation of apoptotic process involved in morphogenesis (GO:1902337)2.34047386
161establishment of endothelial barrier (GO:0061028)2.33962079
162response to activity (GO:0014823)2.33690785
163skin morphogenesis (GO:0043589)2.33650142
164establishment of apical/basal cell polarity (GO:0035089)2.33282649
165COPI coating of Golgi vesicle (GO:0048205)2.33148777
166Golgi transport vesicle coating (GO:0048200)2.33148777
167regulation of sequestering of triglyceride (GO:0010889)2.31795952
168apoptotic process involved in development (GO:1902742)2.31710873
169oxidative phosphorylation (GO:0006119)2.31180830
170regulation of acyl-CoA biosynthetic process (GO:0050812)2.30922468
171endothelial tube morphogenesis (GO:0061154)2.30019285
172morphogenesis of an endothelium (GO:0003159)2.30019285
173heterochromatin organization (GO:0070828)2.29410973
174cell migration involved in sprouting angiogenesis (GO:0002042)2.29026553
175cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27133452
176regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.26793992
177polarized epithelial cell differentiation (GO:0030859)2.25988460
178hippo signaling (GO:0035329)2.25606918
179regulation of translational fidelity (GO:0006450)2.25116998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.49559042
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71123870
3E2F7_22180533_ChIP-Seq_HELA_Human3.03449037
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86631342
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62360424
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57178194
7STAT3_1855785_ChIP-Seq_MESCs_Mouse2.34035436
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.30682435
9ZNF263_19887448_ChIP-Seq_K562_Human2.30251375
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28914510
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.27998414
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.15223473
13CLOCK_20551151_ChIP-Seq_293T_Human2.13614317
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01100827
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00713340
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00196825
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98145750
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.89358951
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79143942
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.76999554
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76889590
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75640081
23ATF3_27146783_Chip-Seq_COLON_Human1.74947902
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72930618
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72310633
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72310633
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72310633
28* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66096601
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64533311
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63049964
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60127377
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59976766
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59850094
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58932430
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56362816
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55710903
37RACK7_27058665_Chip-Seq_MCF-7_Human1.53555540
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50486283
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48895388
40AR_21909140_ChIP-Seq_LNCAP_Human1.43415147
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.42696711
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.42696711
43MYC_22102868_ChIP-Seq_BL_Human1.42073298
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41193347
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40427864
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39558883
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37470182
48VDR_21846776_ChIP-Seq_THP-1_Human1.37445183
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37251216
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.36161659
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36134146
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36097957
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34374929
54* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34127588
55* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33710137
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.33090418
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32888719
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.32843614
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.29909642
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29629934
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29034168
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27922373
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26968226
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26903323
65* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23779035
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23426529
67KDM2B_26808549_Chip-Seq_K562_Human1.22570717
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22412170
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22186859
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21368958
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21365977
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.21176586
73SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20543791
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20044925
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19111051
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.18388870
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17749880
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17237097
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16749284
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16675718
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16675718
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16638423
83LXR_22292898_ChIP-Seq_THP-1_Human1.16254935
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15820155
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14104217
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.13756689
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11866655
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11645164
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.10819635
90KDM2B_26808549_Chip-Seq_DND41_Human1.10744595
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09998606
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09849218
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09580029
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08938079
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08748394
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08201871
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07732415
98VDR_24763502_ChIP-Seq_THP-1_Human1.06771129
99NCOR1_26117541_ChIP-Seq_K562_Human1.06619506
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06530668
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.06514373
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06482501
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06270344
104NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05956492
105TCF7_22412390_ChIP-Seq_EML_Mouse1.05596344
106XRN2_22483619_ChIP-Seq_HELA_Human1.05180315
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04917904
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04562588
109* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03834356
110GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02549639
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01870765
112SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01291288
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00498824
114TP53_22127205_ChIP-Seq_IMR90_Human1.00291549
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00265197
116* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99254314
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99235758
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.98483714
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97505744
120MAF_26560356_Chip-Seq_TH1_Human0.97102584
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96610080
122CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94762933
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.94470881
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93898991
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93389482
126TET1_21451524_ChIP-Seq_MESCs_Mouse0.93257687
127GATA6_25053715_ChIP-Seq_YYC3_Human0.93134634
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92396498
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92264764
130TFEB_21752829_ChIP-Seq_HELA_Human0.91897666
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91889980
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91778894
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91731050
134TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91713439
135* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91701758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.74576739
2MP0005451_abnormal_body_composition3.74037238
3MP0000751_myopathy3.27951692
4MP0003646_muscle_fatigue3.26681129
5MP0003705_abnormal_hypodermis_morpholog3.10478888
6MP0004084_abnormal_cardiac_muscle3.09848048
7MP0000749_muscle_degeneration2.99816919
8MP0002837_dystrophic_cardiac_calcinosis2.98658533
9MP0008438_abnormal_cutaneous_collagen2.95896347
10MP0000750_abnormal_muscle_regeneration2.87393120
11MP0005058_abnormal_lysosome_morphology2.74192806
12MP0004087_abnormal_muscle_fiber2.38554137
13MP0005330_cardiomyopathy2.36040584
14MP0003566_abnormal_cell_adhesion2.31324895
15MP0004036_abnormal_muscle_relaxation2.30438656
16MP0002254_reproductive_system_inflammat2.25477769
17MP0005275_abnormal_skin_tensile2.17106881
18MP0010352_gastrointestinal_tract_polyps2.08251506
19MP0002269_muscular_atrophy2.06400230
20MP0002106_abnormal_muscle_physiology1.99164015
21MP0010630_abnormal_cardiac_muscle1.88252064
22MP0003828_pulmonary_edema1.84389542
23MP0000759_abnormal_skeletal_muscle1.84322364
24MP0004215_abnormal_myocardial_fiber1.77443612
25MP0004145_abnormal_muscle_electrophysio1.75808657
26MP0003436_decreased_susceptibility_to1.72882622
27MP0000733_abnormal_muscle_development1.72021516
28MP0009785_altered_susceptibility_to1.67223367
29MP0004272_abnormal_basement_membrane1.66975965
30* MP0002148_abnormal_hypersensitivity_rea1.65975355
31MP0005369_muscle_phenotype1.63760124
32MP0005620_abnormal_muscle_contractility1.62937838
33MP0004130_abnormal_muscle_cell1.61501521
34MP0008775_abnormal_heart_ventricle1.60738490
35MP0005385_cardiovascular_system_phenoty1.59985368
36MP0001544_abnormal_cardiovascular_syste1.59985368
37MP0008004_abnormal_stomach_pH1.58131324
38MP0004233_abnormal_muscle_weight1.57370713
39MP0000747_muscle_weakness1.57363487
40MP0002972_abnormal_cardiac_muscle1.56353689
41MP0004947_skin_inflammation1.54689023
42MP0006082_CNS_inflammation1.54112927
43MP0003075_altered_response_to1.51706843
44MP0003279_aneurysm1.51391292
45MP0002139_abnormal_hepatobiliary_system1.48696873
46MP0005076_abnormal_cell_differentiation1.48619334
47MP0010030_abnormal_orbit_morphology1.44311961
48MP0003221_abnormal_cardiomyocyte_apopto1.42782475
49MP0003941_abnormal_skin_development1.37395776
50MP0006138_congestive_heart_failure1.35718265
51MP0003191_abnormal_cellular_cholesterol1.35653610
52MP0005023_abnormal_wound_healing1.34375577
53MP0000858_altered_metastatic_potential1.34243201
54MP0001853_heart_inflammation1.29049641
55MP0003567_abnormal_fetal_cardiomyocyte1.27544963
56* MP0005666_abnormal_adipose_tissue1.26350113
57MP0000343_altered_response_to1.25770093
58MP0002332_abnormal_exercise_endurance1.25117006
59MP0001533_abnormal_skeleton_physiology1.24717083
60MP0005670_abnormal_white_adipose1.23556946
61MP0003724_increased_susceptibility_to1.23024994
62MP0005623_abnormal_meninges_morphology1.22459337
63MP0001958_emphysema1.21368417
64MP0005167_abnormal_blood-brain_barrier1.19490307
65MP0001790_abnormal_immune_system1.17003713
66MP0005387_immune_system_phenotype1.17003713
67MP0010368_abnormal_lymphatic_system1.16620188
68MP0005503_abnormal_tendon_morphology1.16502755
69MP0004510_myositis1.14142252
70MP0002998_abnormal_bone_remodeling1.12815485
71MP0009764_decreased_sensitivity_to1.08907114
72MP0003950_abnormal_plasma_membrane1.06372315
73MP0003806_abnormal_nucleotide_metabolis1.06154944
74MP0003137_abnormal_impulse_conducting1.05832457
75MP0001849_ear_inflammation1.05668720
76MP0004858_abnormal_nervous_system1.05460243
77MP0004957_abnormal_blastocyst_morpholog1.04998381
78MP0000003_abnormal_adipose_tissue1.04981017
79MP0010234_abnormal_vibrissa_follicle1.04791814
80MP0005166_decreased_susceptibility_to1.04413704
81MP0000266_abnormal_heart_morphology1.04191785
82MP0004484_altered_response_of1.03444554
83MP0003984_embryonic_growth_retardation1.03215144
84MP0001542_abnormal_bone_strength1.02877642
85MP0005000_abnormal_immune_tolerance1.02868985
86MP0002088_abnormal_embryonic_growth/wei1.02499749
87MP0002108_abnormal_muscle_morphology1.02221143
88MP0002127_abnormal_cardiovascular_syste1.01667568
89MP0002060_abnormal_skin_morphology1.00134224
90MP0000767_abnormal_smooth_muscle0.99482153
91MP0005025_abnormal_response_to0.97447914
92MP0005380_embryogenesis_phenotype0.95109645
93MP0001672_abnormal_embryogenesis/_devel0.95109645
94MP0001879_abnormal_lymphatic_vessel0.94294208
95* MP0004185_abnormal_adipocyte_glucose0.94117558
96MP0002877_abnormal_melanocyte_morpholog0.93702132
97MP0002419_abnormal_innate_immunity0.92179567
98MP0001730_embryonic_growth_arrest0.91927087
99MP0010155_abnormal_intestine_physiology0.91191825
100MP0003091_abnormal_cell_migration0.90773575
101* MP0005375_adipose_tissue_phenotype0.90161275
102MP0008260_abnormal_autophagy0.90046872
103MP0002138_abnormal_hepatobiliary_system0.89227983
104MP0009333_abnormal_splenocyte_physiolog0.88367304
105MP0002796_impaired_skin_barrier0.86692715
106MP0002128_abnormal_blood_circulation0.85977672
107MP0009278_abnormal_bone_marrow0.85716858
108MP0001216_abnormal_epidermal_layer0.85435043
109MP0002925_abnormal_cardiovascular_devel0.84927594
110MP0000013_abnormal_adipose_tissue0.82812645
111MP0002086_abnormal_extraembryonic_tissu0.82715717
112MP0008469_abnormal_protein_level0.80885463
113MP0003453_abnormal_keratinocyte_physiol0.80724262
114MP0002234_abnormal_pharynx_morphology0.80689995
115MP0003693_abnormal_embryo_hatching0.78688752
116MP0004197_abnormal_fetal_growth/weight/0.78456710
117MP0002933_joint_inflammation0.77666805
118MP0001697_abnormal_embryo_size0.77284474
119MP0005165_increased_susceptibility_to0.76737450
120MP0001614_abnormal_blood_vessel0.76618784
121MP0002896_abnormal_bone_mineralization0.76285279
122MP0006036_abnormal_mitochondrial_physio0.76172676
123MP0005164_abnormal_response_to0.75915346
124MP0010307_abnormal_tumor_latency0.73949459
125MP0005501_abnormal_skin_physiology0.73865972
126MP0005257_abnormal_intraocular_pressure0.73676509
127MP0005595_abnormal_vascular_smooth0.73675017
128MP0009840_abnormal_foam_cell0.73668321
129MP0001243_abnormal_dermal_layer0.71348024
130MP0005508_abnormal_skeleton_morphology0.70846530
131MP0000350_abnormal_cell_proliferation0.70835615
132MP0005266_abnormal_metabolism0.70412044
133MP0003077_abnormal_cell_cycle0.70349230
134MP0003300_gastrointestinal_ulcer0.68708527
135MP0002085_abnormal_embryonic_tissue0.68243340
136MP0006054_spinal_hemorrhage0.67148102
137MP0003448_altered_tumor_morphology0.66001144
138MP0002080_prenatal_lethality0.65849175
139MP0009053_abnormal_anal_canal0.65266568

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)5.76406549
2Exercise-induced muscle cramps (HP:0003710)5.28596378
3Muscle fiber splitting (HP:0003555)5.15514980
4Ventricular tachycardia (HP:0004756)4.56261037
5Type 1 muscle fiber predominance (HP:0003803)4.55861218
6Exercise-induced myalgia (HP:0003738)4.42359549
7Sudden death (HP:0001699)4.39073341
8Muscle fiber inclusion bodies (HP:0100299)4.34059753
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.25993346
10Hyporeflexia of lower limbs (HP:0002600)4.19656035
11Calf muscle hypertrophy (HP:0008981)4.19354999
12Right ventricular cardiomyopathy (HP:0011663)4.07969805
13Muscle hypertrophy of the lower extremities (HP:0008968)4.05713399
14Myoglobinuria (HP:0002913)3.94490498
15Difficulty climbing stairs (HP:0003551)3.90652725
16Protrusio acetabuli (HP:0003179)3.76544780
17Difficulty running (HP:0009046)3.73629378
18Abnormality of glycolipid metabolism (HP:0010969)3.69188150
19Abnormality of liposaccharide metabolism (HP:0010968)3.69188150
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.69188150
21Distal lower limb muscle weakness (HP:0009053)3.62718280
22Rhabdomyolysis (HP:0003201)3.61973818
23Abnormality of the calf musculature (HP:0001430)3.61488625
24EMG: myopathic abnormalities (HP:0003458)3.59744659
25Nemaline bodies (HP:0003798)3.58286250
26Centrally nucleated skeletal muscle fibers (HP:0003687)3.55062887
27Premature rupture of membranes (HP:0001788)3.46040487
28Lipoatrophy (HP:0100578)3.41767157
29Nuclear cataract (HP:0100018)3.29353415
30Round ear (HP:0100830)3.24087914
31Abnormality of the left ventricular outflow tract (HP:0011103)3.06703966
32Subaortic stenosis (HP:0001682)3.06703966
33Axonal loss (HP:0003447)3.00161527
34Mildly elevated creatine phosphokinase (HP:0008180)2.97408436
35Distal arthrogryposis (HP:0005684)2.97083029
36Spinal rigidity (HP:0003306)2.97048585
37Myopathic facies (HP:0002058)2.96339298
38Abnormality of skeletal muscle fiber size (HP:0012084)2.91714399
39Asymmetric septal hypertrophy (HP:0001670)2.85453661
40Ankle contracture (HP:0006466)2.83159499
41Increased variability in muscle fiber diameter (HP:0003557)2.82563615
42Ulnar deviation of the wrist (HP:0003049)2.79545097
43Myotonia (HP:0002486)2.78941693
44Atrial fibrillation (HP:0005110)2.76253884
45Systemic lupus erythematosus (HP:0002725)2.66164945
46Dilated cardiomyopathy (HP:0001644)2.65561110
47Distal lower limb amyotrophy (HP:0008944)2.65486927
48Calcaneovalgus deformity (HP:0001848)2.62993984
49Muscle stiffness (HP:0003552)2.62976010
50Cerebral aneurysm (HP:0004944)2.61491726
51Primary atrial arrhythmia (HP:0001692)2.57519937
52Supraventricular arrhythmia (HP:0005115)2.55570801
53Areflexia of lower limbs (HP:0002522)2.54982177
54Supraventricular tachycardia (HP:0004755)2.51325050
55Bulbar palsy (HP:0001283)2.51227220
56Limb-girdle muscle atrophy (HP:0003797)2.50774266
57Neck muscle weakness (HP:0000467)2.46159601
58Palpitations (HP:0001962)2.37705655
59Deformed tarsal bones (HP:0008119)2.35302848
60Testicular atrophy (HP:0000029)2.32162883
61Scapular winging (HP:0003691)2.32056432
62Dysostosis multiplex (HP:0000943)2.31594979
63Abnormality of the calcaneus (HP:0008364)2.28134112
64Loss of speech (HP:0002371)2.21575660
65Broad metatarsal (HP:0001783)2.16433698
66Interstitial pulmonary disease (HP:0006530)2.16162524
67Shallow orbits (HP:0000586)2.15714337
68Atrophic scars (HP:0001075)2.15688414
69Achilles tendon contracture (HP:0001771)2.15405054
70Myocardial infarction (HP:0001658)2.15306166
71Vacuolated lymphocytes (HP:0001922)2.10069299
72Multiple enchondromatosis (HP:0005701)2.08285875
73Ventricular arrhythmia (HP:0004308)2.05327565
74Ragged-red muscle fibers (HP:0003200)2.05175217
75Malignant hyperthermia (HP:0002047)2.04146590
76Wrist flexion contracture (HP:0001239)2.03653799
77Generalized amyotrophy (HP:0003700)2.03444428
78Abnormal atrioventricular conduction (HP:0005150)2.01275187
79Limb-girdle muscle weakness (HP:0003325)2.01023709
80Bundle branch block (HP:0011710)2.00833525
81Frequent falls (HP:0002359)2.00288974
82Muscular dystrophy (HP:0003560)1.96768787
83Hypoplastic ischia (HP:0003175)1.96547076
84Generalized muscle weakness (HP:0003324)1.95586498
85Rectal prolapse (HP:0002035)1.94377311
86Trismus (HP:0000211)1.94346064
87Abnormality of the Achilles tendon (HP:0005109)1.89764172
88Aortic dissection (HP:0002647)1.87440918
89Progressive muscle weakness (HP:0003323)1.86924885
90Increased density of long bones (HP:0006392)1.86659459
91Neurofibrillary tangles (HP:0002185)1.85946755
92Slender build (HP:0001533)1.84153621
93EMG: neuropathic changes (HP:0003445)1.83995947
94Facial diplegia (HP:0001349)1.83827848
95Thin bony cortex (HP:0002753)1.81038318
96Aneurysm (HP:0002617)1.80697308
97Absent phalangeal crease (HP:0006109)1.80503096
98Soft skin (HP:0000977)1.78998525
99Increased serum ferritin (HP:0003281)1.78960920
100Fragile skin (HP:0001030)1.77926249
101Atrioventricular block (HP:0001678)1.77606005
102Glomerulonephritis (HP:0000099)1.76868102
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76028011
104Abnormality of polysaccharide metabolism (HP:0011012)1.76028011
105Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76028011
106Abnormality of complement system (HP:0005339)1.75772015
107Heart block (HP:0012722)1.75199239
108Hip contracture (HP:0003273)1.74247722
109Increased cerebral lipofuscin (HP:0011813)1.72753822
110Cervical subluxation (HP:0003308)1.71791517
111Mesangial abnormality (HP:0001966)1.70373915
112Osteolytic defects of the hand bones (HP:0009699)1.70261568
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.70261568
114Aortic aneurysm (HP:0004942)1.69591388
115Distal upper limb amyotrophy (HP:0007149)1.69228140
116Upper limb amyotrophy (HP:0009129)1.69228140
117Abnormality of the ischium (HP:0003174)1.68812473
118Hyperacusis (HP:0010780)1.68580854
119Lower limb amyotrophy (HP:0007210)1.68035811
120Disinhibition (HP:0000734)1.67189296
121Polycythemia (HP:0001901)1.66941488
122Urinary glycosaminoglycan excretion (HP:0003541)1.66842490
123Mucopolysacchariduria (HP:0008155)1.66842490
124Cerebral inclusion bodies (HP:0100314)1.66563893
125Syncope (HP:0001279)1.66379430
126Foot dorsiflexor weakness (HP:0009027)1.66065483
127Pelvic girdle muscle weakness (HP:0003749)1.65662752
128Abnormality of the shoulder girdle musculature (HP:0001435)1.65502953
129Peritonitis (HP:0002586)1.64741880
130Rimmed vacuoles (HP:0003805)1.64043480
131Breech presentation (HP:0001623)1.63984211
132Shoulder girdle muscle weakness (HP:0003547)1.63017022
133Vertebral compression fractures (HP:0002953)1.62999934
134Reduced subcutaneous adipose tissue (HP:0003758)1.62803031
135Abnormality of macrophages (HP:0004311)1.62482439
136Proximal amyotrophy (HP:0007126)1.62375252
137Complement deficiency (HP:0004431)1.60012684
138Natal tooth (HP:0000695)1.58198048
139Selective tooth agenesis (HP:0001592)1.57773155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.58199347
2IRAK34.67084198
3TRIB33.38144496
4PKN22.91267372
5OBSCN2.82161472
6EPHA22.59070818
7NEK12.41307743
8PRPF4B2.14388816
9DMPK2.11146680
10MOS2.03865624
11MAP3K141.98710191
12PHKG21.94517700
13PHKG11.94517700
14PDK31.72748194
15PDK41.72748194
16ERN11.71351494
17MAPKAPK31.67237311
18CDC42BPA1.66981006
19BCKDK1.66963327
20MAP2K31.66621628
21PAK41.66428687
22RIPK11.65718895
23MYLK1.62177409
24LATS21.56612140
25MAP3K31.52625887
26PDGFRA1.52078203
27GRK71.50162602
28PIK3CA1.50031319
29SMG11.44403136
30RPS6KB21.41720585
31DDR21.40648583
32LMTK21.40614312
33TIE11.38697428
34PDK21.33515482
35FLT31.29769028
36STK38L1.27116172
37EEF2K1.25537089
38KDR1.23679815
39LATS11.23038252
40BUB11.21639349
41ARAF1.20442250
42LRRK21.18752080
43MAP3K101.18572761
44NEK91.17955733
45MAP3K111.14957103
46STK101.10986567
47BMX1.10535903
48PTK61.08892959
49TRPM71.06711244
50ABL21.05357919
51TGFBR11.03002642
52NME21.02771661
53MAP3K131.02338756
54RPS6KA41.00655554
55FER1.00395384
56CDK121.00154067
57TGFBR20.99875470
58ILK0.99599396
59MATK0.97611391
60IKBKB0.93436417
61MAP3K80.91786470
62EPHB20.85392484
63MAP3K10.85007639
64SIK10.83992758
65PIM20.83701902
66NME10.83672173
67EIF2AK10.82043220
68EPHB10.81275028
69PIK3CG0.81250872
70WEE10.80027588
71TBK10.79167239
72TTK0.78910407
73TESK10.76162674
74MTOR0.76084385
75MAP3K70.72642817
76FGR0.71503813
77ZAK0.69951970
78PAK20.68972335
79PTK20.68342516
80IRAK40.67373500
81JAK30.65831517
82NEK20.64511217
83STK40.64282386
84DAPK30.64210177
85FGFR40.63259873
86STK30.61403836
87IKBKE0.60915570
88BRAF0.60895362
89PRKD10.59864082
90IRAK20.57530353
91CLK10.57078199
92AKT20.56350521
93ERBB40.55585337
94MET0.55406307
95MAP3K90.55138541
96AURKB0.54733008
97PBK0.53587230
98TAOK20.51266612
99MAP2K60.51180794
100CDK70.50714804
101TYK20.50109923
102TYRO30.50054383
103TESK20.49664454
104MAP3K60.49564411
105STK240.49416710
106MAP3K50.48774271
107PIM10.48702268
108MAP2K20.48537956
109ROCK10.47523100
110PRKAA20.47066370
111ICK0.46763147
112CDK40.46441717
113MAPK40.46321122
114TAOK10.46091205
115EPHA30.44327718
116CDK60.44244873
117ZAP700.43955285
118CAMK2G0.42971514
119MAPK120.42507043
120MAPKAPK20.41791787
121CHUK0.40480006
122PDGFRB0.40199413
123DYRK1B0.39989778
124LIMK10.39836111
125PAK10.39831983
126MST1R0.39406035
127CSK0.38718118
128PLK10.38163208
129PAK30.37123920
130ALK0.36941906
131PRKG20.36839057
132KSR20.36085766
133MAPK110.35637037
134SIK30.35414092
135RPS6KL10.33971814
136RPS6KC10.33971814
137MAPK70.33237030
138PDPK10.31920062
139PKN10.30946216
140RPS6KA20.29333182

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.90394075
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.51271865
3Other glycan degradation_Homo sapiens_hsa005113.00254948
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.72781921
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42183865
6Dilated cardiomyopathy_Homo sapiens_hsa054142.39910250
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28626365
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.24016278
9Carbon metabolism_Homo sapiens_hsa012002.17078341
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13221691
11Viral myocarditis_Homo sapiens_hsa054161.93490185
12Prion diseases_Homo sapiens_hsa050201.90195415
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88879907
14Pertussis_Homo sapiens_hsa051331.86157360
15Lysosome_Homo sapiens_hsa041421.71762806
16Adherens junction_Homo sapiens_hsa045201.70855430
17Fatty acid degradation_Homo sapiens_hsa000711.66231960
18ECM-receptor interaction_Homo sapiens_hsa045121.64701607
19Osteoclast differentiation_Homo sapiens_hsa043801.64639586
20Focal adhesion_Homo sapiens_hsa045101.62306941
21Cardiac muscle contraction_Homo sapiens_hsa042601.60245951
22Biosynthesis of amino acids_Homo sapiens_hsa012301.58774579
23African trypanosomiasis_Homo sapiens_hsa051431.55337283
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.54988859
25Rheumatoid arthritis_Homo sapiens_hsa053231.51371897
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49636950
27One carbon pool by folate_Homo sapiens_hsa006701.47227627
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41687966
29Propanoate metabolism_Homo sapiens_hsa006401.40997737
30Small cell lung cancer_Homo sapiens_hsa052221.40573592
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33278242
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32936238
33HIF-1 signaling pathway_Homo sapiens_hsa040661.32311988
34Tight junction_Homo sapiens_hsa045301.31650991
35Hepatitis C_Homo sapiens_hsa051601.28941387
36Proteoglycans in cancer_Homo sapiens_hsa052051.27173477
37Galactose metabolism_Homo sapiens_hsa000521.26614161
38DNA replication_Homo sapiens_hsa030301.24323747
39Bladder cancer_Homo sapiens_hsa052191.20147095
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19028521
41Pyruvate metabolism_Homo sapiens_hsa006201.15550941
42p53 signaling pathway_Homo sapiens_hsa041151.15374086
43Allograft rejection_Homo sapiens_hsa053301.14951638
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.14490426
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13561645
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12912211
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12391561
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.11135696
49Fructose and mannose metabolism_Homo sapiens_hsa000511.10572403
50RNA transport_Homo sapiens_hsa030131.09588034
51Ribosome_Homo sapiens_hsa030101.08527419
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06622553
53Tuberculosis_Homo sapiens_hsa051521.05935235
54Insulin resistance_Homo sapiens_hsa049311.05796794
55Adipocytokine signaling pathway_Homo sapiens_hsa049201.05035805
56Amoebiasis_Homo sapiens_hsa051461.04392890
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04131329
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03843845
59Mismatch repair_Homo sapiens_hsa034301.03316854
60Asthma_Homo sapiens_hsa053101.03185046
61MicroRNAs in cancer_Homo sapiens_hsa052060.97325726
62Legionellosis_Homo sapiens_hsa051340.95838055
63Starch and sucrose metabolism_Homo sapiens_hsa005000.95025472
64Hippo signaling pathway_Homo sapiens_hsa043900.94861379
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93501582
66Fatty acid metabolism_Homo sapiens_hsa012120.93152726
67Base excision repair_Homo sapiens_hsa034100.91946159
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90059604
69Toxoplasmosis_Homo sapiens_hsa051450.88942440
70Proteasome_Homo sapiens_hsa030500.88108993
71Staphylococcus aureus infection_Homo sapiens_hsa051500.87061968
72Apoptosis_Homo sapiens_hsa042100.85786115
73Hepatitis B_Homo sapiens_hsa051610.85670550
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.84629207
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83315521
76Notch signaling pathway_Homo sapiens_hsa043300.81951662
77Sulfur metabolism_Homo sapiens_hsa009200.81298091
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81038418
79AMPK signaling pathway_Homo sapiens_hsa041520.80941392
80Measles_Homo sapiens_hsa051620.80709718
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80699959
82Arginine and proline metabolism_Homo sapiens_hsa003300.80320101
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.76627484
84Chronic myeloid leukemia_Homo sapiens_hsa052200.75701217
85HTLV-I infection_Homo sapiens_hsa051660.74497086
86Viral carcinogenesis_Homo sapiens_hsa052030.74158775
87* Insulin signaling pathway_Homo sapiens_hsa049100.73929495
88TGF-beta signaling pathway_Homo sapiens_hsa043500.73698729
89Spliceosome_Homo sapiens_hsa030400.72247169
90Cell cycle_Homo sapiens_hsa041100.72230455
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71786836
92Pentose phosphate pathway_Homo sapiens_hsa000300.71242811
93PPAR signaling pathway_Homo sapiens_hsa033200.70248109
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69721917
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69668408
96Thyroid cancer_Homo sapiens_hsa052160.68685532
97Sulfur relay system_Homo sapiens_hsa041220.68285188
98Shigellosis_Homo sapiens_hsa051310.68256854
99Leishmaniasis_Homo sapiens_hsa051400.68046495
100Lysine degradation_Homo sapiens_hsa003100.67404378
101Phenylalanine metabolism_Homo sapiens_hsa003600.66685690
102Parkinsons disease_Homo sapiens_hsa050120.65399223
103Graft-versus-host disease_Homo sapiens_hsa053320.65325739
104Acute myeloid leukemia_Homo sapiens_hsa052210.63540606
105Complement and coagulation cascades_Homo sapiens_hsa046100.63149417
106mTOR signaling pathway_Homo sapiens_hsa041500.62825742
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62796991
108Basal cell carcinoma_Homo sapiens_hsa052170.60319889
109Pancreatic cancer_Homo sapiens_hsa052120.60198591
110B cell receptor signaling pathway_Homo sapiens_hsa046620.60025576
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57528075
112TNF signaling pathway_Homo sapiens_hsa046680.57286220
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56784012
114Herpes simplex infection_Homo sapiens_hsa051680.55858601
115Autoimmune thyroid disease_Homo sapiens_hsa053200.55505094
116Epstein-Barr virus infection_Homo sapiens_hsa051690.55494898
117Pathways in cancer_Homo sapiens_hsa052000.54780747
118Sphingolipid metabolism_Homo sapiens_hsa006000.54635758
119Prolactin signaling pathway_Homo sapiens_hsa049170.54613114
120Malaria_Homo sapiens_hsa051440.54603956
121Glucagon signaling pathway_Homo sapiens_hsa049220.53885423
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.53650245
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53481111
124Salmonella infection_Homo sapiens_hsa051320.53348094
125Antigen processing and presentation_Homo sapiens_hsa046120.51263020
126Fat digestion and absorption_Homo sapiens_hsa049750.51131482
127Renal cell carcinoma_Homo sapiens_hsa052110.50256168
128Glutathione metabolism_Homo sapiens_hsa004800.50115801
129Selenocompound metabolism_Homo sapiens_hsa004500.48956663
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47780216
131Protein digestion and absorption_Homo sapiens_hsa049740.47111113
132Influenza A_Homo sapiens_hsa051640.45538132
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.45537484
134Arginine biosynthesis_Homo sapiens_hsa002200.45167664
135Folate biosynthesis_Homo sapiens_hsa007900.44617338
136VEGF signaling pathway_Homo sapiens_hsa043700.44460923
137Caffeine metabolism_Homo sapiens_hsa002320.44042574
138Melanoma_Homo sapiens_hsa052180.43453206
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43441183
140Hematopoietic cell lineage_Homo sapiens_hsa046400.40905565
141Vibrio cholerae infection_Homo sapiens_hsa051100.40659448
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40226758
143GnRH signaling pathway_Homo sapiens_hsa049120.39072832
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38312493
145Platelet activation_Homo sapiens_hsa046110.36840373
146Phagosome_Homo sapiens_hsa041450.36563484
147Fatty acid biosynthesis_Homo sapiens_hsa000610.36435769

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