TRIM75P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell receptor signaling pathway (GO:0050860)7.31546228
2phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)6.30130612
3protein-chromophore linkage (GO:0018298)6.23999491
4relaxation of smooth muscle (GO:0044557)5.99305272
5multicellular organismal reproductive behavior (GO:0033057)5.66132811
6negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)5.62165630
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.09680337
8activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.95226714
9meiotic chromosome segregation (GO:0045132)4.78246753
10detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.66635879
11negative regulation of myotube differentiation (GO:0010832)4.64675702
12positive regulation of protein homooligomerization (GO:0032464)4.60000343
13transcription from mitochondrial promoter (GO:0006390)4.36723786
14multicellular organism reproduction (GO:0032504)4.28908333
15regulation of T cell receptor signaling pathway (GO:0050856)4.01157401
16viral entry into host cell (GO:0046718)3.94430611
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.88659744
18otic vesicle formation (GO:0030916)3.84862625
19attachment of spindle microtubules to kinetochore (GO:0008608)3.81556955
20intestinal epithelial cell development (GO:0060576)3.80820388
21sensory perception of chemical stimulus (GO:0007606)3.79401245
22multi-organism reproductive behavior (GO:0044705)3.77646579
23transmission of nerve impulse (GO:0019226)3.77568748
24regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.73098017
25reproductive behavior (GO:0019098)3.72177996
26positive regulation of extracellular matrix organization (GO:1903055)3.52388847
27positive regulation of uterine smooth muscle contraction (GO:0070474)3.49160441
28fusion of sperm to egg plasma membrane (GO:0007342)3.48912583
29synaptic transmission, dopaminergic (GO:0001963)3.46842289
30chaperone-mediated protein transport (GO:0072321)3.44679559
31detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.42864280
32cytoplasmic microtubule organization (GO:0031122)3.41846559
33long term synaptic depression (GO:0060292)3.36609286
34protein K6-linked ubiquitination (GO:0085020)3.32666578
35nephron tubule formation (GO:0072079)3.28284740
36mitotic metaphase plate congression (GO:0007080)3.27371664
37rRNA modification (GO:0000154)3.22179185
38limb bud formation (GO:0060174)3.14774832
39pyrimidine-containing compound salvage (GO:0008655)3.12689002
40pyrimidine nucleoside salvage (GO:0043097)3.12689002
41regulation of DNA-templated transcription, initiation (GO:2000142)3.12269586
42ectodermal placode formation (GO:0060788)3.09952230
43NLS-bearing protein import into nucleus (GO:0006607)3.02331179
44pyrimidine-containing compound transmembrane transport (GO:0072531)3.01683202
45regulation of acrosome reaction (GO:0060046)3.00899913
46negative regulation of retinoic acid receptor signaling pathway (GO:0048387)21.1919013
47male meiosis I (GO:0007141)2.99025109
48reproduction (GO:0000003)2.93161673
49negative regulation of smooth muscle contraction (GO:0045986)2.92439837
50entry into host (GO:0044409)2.91297086
51entry into other organism involved in symbiotic interaction (GO:0051828)2.91297086
52movement in host environment (GO:0052126)2.91297086
53entry into host cell (GO:0030260)2.91297086
54movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.91297086
55entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.91297086
56nitric oxide mediated signal transduction (GO:0007263)2.86122445
57glomerular visceral epithelial cell development (GO:0072015)2.83627484
58pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.81863495
59UMP biosynthetic process (GO:0006222)2.81863495
60pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.81863495
61UMP metabolic process (GO:0046049)2.81863495
62regulation of female gonad development (GO:2000194)2.73916933
63detection of chemical stimulus involved in sensory perception (GO:0050907)2.73896180
64tRNA methylation (GO:0030488)2.73466222
65rRNA methylation (GO:0031167)2.72304668
66positive regulation of interleukin-2 production (GO:0032743)2.72199166
67cell aggregation (GO:0098743)2.71435983
68cartilage condensation (GO:0001502)2.71435983
69sensory perception of taste (GO:0050909)2.70682335
70protein insertion into membrane (GO:0051205)2.70588605
71keratinocyte development (GO:0003334)2.69986462
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69619959
73meiosis I (GO:0007127)2.67097498
74regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.66105173
75regulation of G0 to G1 transition (GO:0070316)2.64099954
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64056937
77response to host immune response (GO:0052572)2.64056937
78tachykinin receptor signaling pathway (GO:0007217)2.61666890
79ectoderm development (GO:0007398)2.58402664
80autophagic vacuole assembly (GO:0000045)2.57550157
81regulation of uterine smooth muscle contraction (GO:0070472)2.57260495
82negative regulation of keratinocyte proliferation (GO:0010839)2.56007874
83lung epithelial cell differentiation (GO:0060487)2.55818063
84single fertilization (GO:0007338)2.55671700
85pseudouridine synthesis (GO:0001522)2.52365479
86cGMP biosynthetic process (GO:0006182)2.51855830
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50938812
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49584293
89plasma membrane fusion (GO:0045026)2.48516959
90cellular biogenic amine biosynthetic process (GO:0042401)2.47712322
91regulation of spindle organization (GO:0090224)2.46768533
92positive regulation of cAMP-mediated signaling (GO:0043950)2.46202304
93termination of RNA polymerase III transcription (GO:0006386)2.44795930
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.44795930
95startle response (GO:0001964)2.44683701
96glomerular epithelial cell development (GO:0072310)2.43282250
97galactose metabolic process (GO:0006012)2.42640935
98regulation of retinoic acid receptor signaling pathway (GO:0048385)17.6799509
99regulation of female receptivity (GO:0045924)14.9384133
100female mating behavior (GO:0060180)13.0538557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08890944
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.18955146
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.18955146
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.18955146
5ZNF274_21170338_ChIP-Seq_K562_Hela3.37373621
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.27415533
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23898147
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.15273340
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92131637
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83366011
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65988514
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40226291
13GBX2_23144817_ChIP-Seq_PC3_Human2.28360857
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17372858
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.90010385
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.85358087
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.79271530
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78674278
19TP53_22573176_ChIP-Seq_HFKS_Human1.74235740
20PHF8_20622853_ChIP-Seq_HELA_Human1.65378069
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62904040
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.62444367
23TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.61474498
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59045872
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58484818
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.55958468
27KAP1_22055183_ChIP-Seq_ESCs_Mouse1.54273958
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53961568
29GATA3_21878914_ChIP-Seq_MCF-7_Human1.53289194
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52975658
31FUS_26573619_Chip-Seq_HEK293_Human1.45246843
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.43336194
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43196439
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43196439
35ETV1_20927104_ChIP-Seq_GIST48_Human1.40703689
36HOXB7_26014856_ChIP-Seq_BT474_Human1.40176345
37P300_19829295_ChIP-Seq_ESCs_Human1.39797428
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36822907
39RBPJ_21746931_ChIP-Seq_IB4_Human1.36138789
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35498773
41NFYB_21822215_ChIP-Seq_K562_Human1.34642350
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30856692
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30434810
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29481981
45P53_21459846_ChIP-Seq_SAOS-2_Human1.28777000
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27233520
47STAT1_20625510_ChIP-Seq_HELA_Human1.22460903
48EWS_26573619_Chip-Seq_HEK293_Human1.21944188
49GATA6_21074721_ChIP-Seq_CACO-2_Human1.19306537
50NANOG_19829295_ChIP-Seq_ESCs_Human1.19084696
51SOX2_19829295_ChIP-Seq_ESCs_Human1.19084696
52BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.18209725
53TBL1_22424771_ChIP-Seq_293T_Human1.17704102
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16226516
55MYC_19829295_ChIP-Seq_ESCs_Human1.15548169
56ERA_21632823_ChIP-Seq_H3396_Human1.14089746
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13166032
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13073803
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12148693
60TCF4_23295773_ChIP-Seq_U87_Human1.11041238
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.09900100
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08866088
63TCF4_22108803_ChIP-Seq_LS180_Human1.08083387
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07907004
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07653352
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.07230892
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07071026
68E2F1_20622854_ChIP-Seq_HELA_Human1.06939473
69VDR_23849224_ChIP-Seq_CD4+_Human1.05118156
70FOXH1_21741376_ChIP-Seq_ESCs_Human1.04841012
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04622699
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04085459
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03945583
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03532506
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.01143734
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.00554412
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00467598
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00331806
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99550759
80CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96640118
81VDR_22108803_ChIP-Seq_LS180_Human0.95987219
82GATA3_21867929_ChIP-Seq_TH1_Mouse0.95850096
83YY1_21170310_ChIP-Seq_MESCs_Mouse0.95629797
84FOXM1_23109430_ChIP-Seq_U2OS_Human0.95454394
85REST_21632747_ChIP-Seq_MESCs_Mouse0.95144009
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93827180
87RAC3_21632823_ChIP-Seq_H3396_Human0.93523274
88LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93507773
89WDR5_24793694_ChIP-Seq_LNCAP_Human0.93364849
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91106825
91STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91072025
92SMAD4_21799915_ChIP-Seq_A2780_Human0.89123712
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87554224
94MYC_18940864_ChIP-ChIP_HL60_Human0.86391530
95NCOR_22424771_ChIP-Seq_293T_Human0.84700960
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84140480
97GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.83125973
98AR_20517297_ChIP-Seq_VCAP_Human0.82432385
99STAT3_23295773_ChIP-Seq_U87_Human0.82321922
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82228442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.71303197
2MP0009780_abnormal_chondrocyte_physiolo5.87493644
3MP0000372_irregular_coat_pigmentation4.94263653
4MP0001986_abnormal_taste_sensitivity4.42037382
5MP0002163_abnormal_gland_morphology3.85702889
6MP0000566_synostosis3.41328729
7MP0005423_abnormal_somatic_nervous3.40666701
8MP0005187_abnormal_penis_morphology3.18793539
9MP0002132_abnormal_respiratory_system3.12381554
10MP0010030_abnormal_orbit_morphology2.88518896
11MP0003879_abnormal_hair_cell2.81985204
12MP0006276_abnormal_autonomic_nervous2.72825302
13MP0004381_abnormal_hair_follicle2.64734827
14MP0004885_abnormal_endolymph2.52605553
15MP0003938_abnormal_ear_development2.45633732
16MP0005379_endocrine/exocrine_gland_phen2.44758100
17MP0003718_maternal_effect2.37523163
18MP0003646_muscle_fatigue2.20155317
19MP0003880_abnormal_central_pattern1.88828691
20MP0009379_abnormal_foot_pigmentation1.78964946
21MP0006292_abnormal_olfactory_placode1.70526149
22MP0000647_abnormal_sebaceous_gland1.66907493
23MP0002909_abnormal_adrenal_gland1.66864038
24MP0005410_abnormal_fertilization1.66178220
25MP0003315_abnormal_perineum_morphology1.43601980
26MP0008775_abnormal_heart_ventricle1.38905084
27MP0001968_abnormal_touch/_nociception1.37375323
28MP0005360_urolithiasis1.27897442
29MP0005551_abnormal_eye_electrophysiolog1.18442071
30MP0009384_cardiac_valve_regurgitation1.16771927
31MP0000631_abnormal_neuroendocrine_gland1.15372976
32MP0005171_absent_coat_pigmentation1.14384577
33MP0002233_abnormal_nose_morphology1.14301052
34MP0006072_abnormal_retinal_apoptosis1.12558285
35MP0002653_abnormal_ependyma_morphology1.10512676
36MP0000537_abnormal_urethra_morphology1.09526074
37MP0005395_other_phenotype1.08230352
38MP0000049_abnormal_middle_ear1.07928081
39MP0008789_abnormal_olfactory_epithelium1.06776588
40MP0002736_abnormal_nociception_after1.05870379
41MP0006035_abnormal_mitochondrial_morpho1.04787571
42MP0003119_abnormal_digestive_system1.02002468
43MP0001485_abnormal_pinna_reflex1.01966517
44MP0001963_abnormal_hearing_physiology1.00416854
45MP0006036_abnormal_mitochondrial_physio0.98999956
46MP0004130_abnormal_muscle_cell0.95074960
47MP0009333_abnormal_splenocyte_physiolog0.94067506
48MP0001501_abnormal_sleep_pattern0.93884979
49MP0005451_abnormal_body_composition0.91719282
50MP0008877_abnormal_DNA_methylation0.90530400
51MP0003693_abnormal_embryo_hatching0.88882080
52MP0000383_abnormal_hair_follicle0.88770915
53MP0003638_abnormal_response/metabolism_0.87589910
54MP0001346_abnormal_lacrimal_gland0.85852831
55MP0002210_abnormal_sex_determination0.81311917
56MP0009046_muscle_twitch0.81068166
57MP0002090_abnormal_vision0.79274865
58MP0003567_abnormal_fetal_cardiomyocyte0.77289879
59MP0002876_abnormal_thyroid_physiology0.77053768
60MP0000681_abnormal_thyroid_gland0.76500554
61MP0001293_anophthalmia0.76445816
62MP0002282_abnormal_trachea_morphology0.75315566
63MP0000750_abnormal_muscle_regeneration0.72680520
64MP0002938_white_spotting0.72628694
65MP0000026_abnormal_inner_ear0.72434084
66MP0005257_abnormal_intraocular_pressure0.72211651
67MP0002138_abnormal_hepatobiliary_system0.71110807
68MP0001929_abnormal_gametogenesis0.69375747
69MP0000230_abnormal_systemic_arterial0.69171469
70MP0010368_abnormal_lymphatic_system0.67093445
71MP0004742_abnormal_vestibular_system0.66592081
72MP0002277_abnormal_respiratory_mucosa0.60500903
73MP0003698_abnormal_male_reproductive0.58130635
74MP0004085_abnormal_heartbeat0.57747261
75MP0005367_renal/urinary_system_phenotyp0.56971557
76MP0000516_abnormal_urinary_system0.56971557
77MP0005253_abnormal_eye_physiology0.55922967
78MP0004957_abnormal_blastocyst_morpholog0.55186602
79MP0003137_abnormal_impulse_conducting0.55164612
80MP0002160_abnormal_reproductive_system0.52991384
81MP0002127_abnormal_cardiovascular_syste0.52045061
82MP0003077_abnormal_cell_cycle0.48451970
83MP0005646_abnormal_pituitary_gland0.47879396
84MP0003123_paternal_imprinting0.47762225
85MP0001984_abnormal_olfaction0.47498286
86MP0000358_abnormal_cell_content/0.47197057
87MP0001486_abnormal_startle_reflex0.46152900
88MP0004270_analgesia0.44712115
89MP0002638_abnormal_pupillary_reflex0.43360759
90MP0001764_abnormal_homeostasis0.43268557
91MP0003755_abnormal_palate_morphology0.42928969
92MP0001502_abnormal_circadian_rhythm0.42007379
93MP0008260_abnormal_autophagy0.41768234
94MP0008875_abnormal_xenobiotic_pharmacok0.40369922
95MP0009765_abnormal_xenobiotic_induced0.40320499
96MP0001851_eye_inflammation0.39533053
97MP0000653_abnormal_sex_gland0.39164801
98MP0001881_abnormal_mammary_gland0.39110022
99MP0002572_abnormal_emotion/affect_behav0.38841720
100MP0002111_abnormal_tail_morphology0.38302335

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)7.58610051
2Severe visual impairment (HP:0001141)6.08435361
3Premature skin wrinkling (HP:0100678)5.59766201
4Hemiparesis (HP:0001269)4.52997342
5Dysphonia (HP:0001618)4.52036534
6Abnormal biliary tract physiology (HP:0012439)4.45660125
7Bile duct proliferation (HP:0001408)4.45660125
8Anhidrosis (HP:0000970)4.44330211
9Abnormal rod and cone electroretinograms (HP:0008323)4.33689546
10Absent eyebrow (HP:0002223)4.23051734
11Hypoplasia of the fovea (HP:0007750)4.13436958
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.13436958
13Congenital stationary night blindness (HP:0007642)4.04183232
14Conical tooth (HP:0000698)3.99014175
15Metaphyseal cupping (HP:0003021)3.98298343
16Short chin (HP:0000331)3.80460383
17True hermaphroditism (HP:0010459)3.69067633
18Male infertility (HP:0003251)3.67098245
19Increased connective tissue (HP:0009025)3.61520636
2011 pairs of ribs (HP:0000878)3.60948225
21Shoulder girdle muscle weakness (HP:0003547)3.58638636
22Pelvic girdle muscle weakness (HP:0003749)3.28517413
23Prominent supraorbital ridges (HP:0000336)3.25035433
24Abnormality of the fovea (HP:0000493)3.10560633
25Sparse eyelashes (HP:0000653)3.04475268
26Bony spicule pigmentary retinopathy (HP:0007737)2.93931136
27Cerebellar dysplasia (HP:0007033)2.93302412
28Abnormality of the hip-girdle musculature (HP:0001445)2.90338461
29Abnormality of the musculature of the pelvis (HP:0001469)2.90338461
30Attenuation of retinal blood vessels (HP:0007843)2.83522289
31Keratoconjunctivitis (HP:0001096)2.82278612
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.81866194
33Keratoconjunctivitis sicca (HP:0001097)2.78861960
34Tubular atrophy (HP:0000092)2.75409994
35Microvesicular hepatic steatosis (HP:0001414)2.68871567
36Birth length less than 3rd percentile (HP:0003561)2.67375498
37Rimmed vacuoles (HP:0003805)2.65460749
38Oligodontia (HP:0000677)2.62635443
39Glossoptosis (HP:0000162)2.61232274
40Aplasia/Hypoplasia of the macula (HP:0008059)2.55088674
41Pancreatic cysts (HP:0001737)2.53302835
42Brittle hair (HP:0002299)2.50880596
43Molar tooth sign on MRI (HP:0002419)2.48011554
44Abnormality of midbrain morphology (HP:0002418)2.48011554
45Relative macrocephaly (HP:0004482)2.46954318
46Hypoproteinemia (HP:0003075)2.46023491
47Abnormality of permanent molar morphology (HP:0011071)2.45803613
48Abnormality of the dental root (HP:0006486)2.45803613
49Taurodontia (HP:0000679)2.45803613
50Type I diabetes mellitus (HP:0100651)2.45699738
51Mesangial abnormality (HP:0001966)2.42919166
52Type II lissencephaly (HP:0007260)2.37121305
53Abnormality of the dental pulp (HP:0006479)2.36458602
54Small epiphyses (HP:0010585)2.35914199
55Hypoplastic nipples (HP:0002557)2.35470908
56Hypotrichosis (HP:0001006)2.35340049
57Aplasia/Hypoplasia affecting the retina (HP:0008061)2.33138629
58Hypercortisolism (HP:0001578)2.32060675
59Abnormality of molar (HP:0011077)2.28859531
60Abnormality of molar morphology (HP:0011070)2.28859531
61Constricted visual fields (HP:0001133)2.20916310
62Sex reversal (HP:0012245)2.20491364
63Abnormal sex determination (HP:0012244)2.20491364
64Neonatal respiratory distress (HP:0002643)2.18801994
65Ureteral duplication (HP:0000073)2.15041913
66Stenosis of the external auditory canal (HP:0000402)2.12637247
67Abnormality of macular pigmentation (HP:0008002)2.10609256
68Respiratory difficulties (HP:0002880)2.08587207
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08116597
70Absent hair (HP:0002298)2.07087308
71Severe Myopia (HP:0011003)2.02847490
72Abnormal pancreas size (HP:0012094)2.01399710
73Male pseudohermaphroditism (HP:0000037)1.99724475
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.99064148
75Soft skin (HP:0000977)1.94345689
76Abnormal tarsal ossification (HP:0008369)1.94114992
77Erythroderma (HP:0001019)1.92863026
78X-linked dominant inheritance (HP:0001423)1.90500335
79Pancreatic fibrosis (HP:0100732)1.89994678
803-Methylglutaconic aciduria (HP:0003535)1.88952999
81Neonatal short-limb short stature (HP:0008921)1.82359396
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81529190
83Aplasia/hypoplasia of the uterus (HP:0008684)1.80503673
84Hypergonadotropic hypogonadism (HP:0000815)1.78670275
85Preauricular pit (HP:0004467)1.78033516
86Periauricular skin pits (HP:0100277)1.78033516
87Congenital hip dislocation (HP:0001374)1.77629459
88Focal seizures (HP:0007359)1.77181360
89Sparse lateral eyebrow (HP:0005338)1.76528889
90Gastrointestinal dysmotility (HP:0002579)1.75961172
91Lip pit (HP:0100267)1.75797861
92Limb dystonia (HP:0002451)1.75481466
93Congenital malformation of the right heart (HP:0011723)1.75114033
94Double outlet right ventricle (HP:0001719)1.75114033
95Retinal dysplasia (HP:0007973)1.74596815
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.73902002
97Premature ovarian failure (HP:0008209)1.73774827
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72320197
99Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70741571
100Tinnitus (HP:0000360)1.69861112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.67048479
2FRK4.46846146
3CDK124.05688752
4LATS23.17112114
5PINK12.69890310
6MAP3K102.62206858
7ADRBK22.56246966
8MST42.48857964
9SRPK12.39108601
10STK162.23450690
11KIT2.02227652
12BRSK11.99602467
13ERBB41.97540346
14GRK11.92487006
15MARK31.82660881
16PRKD31.63468516
17PLK21.57678385
18PBK1.55060314
19PKN11.49806173
20IRAK31.48973121
21TESK21.35798308
22PLK11.33838401
23EPHA21.30203339
24STK101.28610149
25AKT21.25202052
26EPHA41.23787863
27LRRK21.21348891
28WNK31.13326242
29BRSK21.12965059
30ERBB21.12288717
31NTRK21.07945136
32PLK31.07718446
33PAK31.03065642
34DAPK20.99860271
35CSNK2A10.96700759
36NEK60.93536824
37MAP3K10.91717283
38ROCK10.86717476
39AURKA0.86406056
40ADRBK10.85842668
41TRIM280.84904277
42PRKD20.82496772
43AURKB0.82262090
44FGFR20.81267148
45NTRK30.79495408
46CSNK1A10.79148609
47CDK190.79053974
48PRKCE0.78495672
49PRKCI0.75063832
50LMTK20.73935179
51CSNK2A20.73789345
52PDK20.73069116
53BMX0.69021240
54PASK0.67745025
55MAP2K70.67385035
56STK380.66365214
57PLK40.66207718
58EPHA30.61300881
59PRKACB0.60844759
60STK40.56871482
61CDK50.56523662
62DYRK20.55265262
63CSNK1G10.55087938
64NME10.54998689
65CAMK2A0.53576782
66CDK20.53187822
67TYRO30.52761051
68MAPK110.51500423
69PRKACG0.50256662
70CDK70.50178584
71CDK11A0.50060855
72PRKCG0.47605059
73STK390.47280824
74RPS6KB10.45216085
75NEK20.44947134
76OXSR10.43922517
77MAPK140.42393552
78ATM0.42386420
79PAK60.41881438
80PRKACA0.41674139
81MAP3K50.41037446
82RPS6KA10.40808692
83DYRK30.40558580
84CDK150.39748948
85TAF10.39612420
86NUAK10.39088799
87EGFR0.38999410
88CDK10.38581561
89PIK3CA0.38195831
90TLK10.37953322
91TXK0.37735436
92PIK3CG0.37369388
93GSK3B0.37312659
94AKT10.37007080
95CSNK1E0.36955635
96PRKD10.36954579
97TAOK30.36580863
98PRKCB0.36314554
99CDK180.36097238
100MAPK130.35146277

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.96606222
2RNA polymerase_Homo sapiens_hsa030203.64466812
3Basal transcription factors_Homo sapiens_hsa030223.37337093
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32219145
5Regulation of autophagy_Homo sapiens_hsa041402.94507812
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.71878913
7Tryptophan metabolism_Homo sapiens_hsa003802.61627885
8Ribosome_Homo sapiens_hsa030102.57088851
9Folate biosynthesis_Homo sapiens_hsa007902.41593231
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33190016
11Taste transduction_Homo sapiens_hsa047422.24142585
12Nicotine addiction_Homo sapiens_hsa050332.04873786
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00283610
14Steroid biosynthesis_Homo sapiens_hsa001001.94272990
15Olfactory transduction_Homo sapiens_hsa047401.84277529
16Arginine and proline metabolism_Homo sapiens_hsa003301.69180418
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59614618
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.57717339
19Caffeine metabolism_Homo sapiens_hsa002321.57612458
20Phototransduction_Homo sapiens_hsa047441.55225206
21Oocyte meiosis_Homo sapiens_hsa041141.50441589
22Nitrogen metabolism_Homo sapiens_hsa009101.44109698
23Pyrimidine metabolism_Homo sapiens_hsa002401.43247760
24Salivary secretion_Homo sapiens_hsa049701.40006612
25Circadian entrainment_Homo sapiens_hsa047131.37491832
26Cardiac muscle contraction_Homo sapiens_hsa042601.36977244
27RNA degradation_Homo sapiens_hsa030181.36415461
28Circadian rhythm_Homo sapiens_hsa047101.36150475
29Fatty acid biosynthesis_Homo sapiens_hsa000611.31610524
30Calcium signaling pathway_Homo sapiens_hsa040201.28707952
31Sulfur relay system_Homo sapiens_hsa041221.28323389
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25792116
33Purine metabolism_Homo sapiens_hsa002301.19003799
34RNA transport_Homo sapiens_hsa030131.16958288
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.15166296
36Collecting duct acid secretion_Homo sapiens_hsa049661.14914775
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14099074
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13003153
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07416206
40Huntingtons disease_Homo sapiens_hsa050161.05282250
41Linoleic acid metabolism_Homo sapiens_hsa005911.03514025
42Parkinsons disease_Homo sapiens_hsa050121.01518535
43GABAergic synapse_Homo sapiens_hsa047270.99411916
44Homologous recombination_Homo sapiens_hsa034400.94712570
45Chemical carcinogenesis_Homo sapiens_hsa052040.94661416
46mRNA surveillance pathway_Homo sapiens_hsa030150.94473816
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91243158
48Spliceosome_Homo sapiens_hsa030400.89255071
49Morphine addiction_Homo sapiens_hsa050320.86395747
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.85662778
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.85412507
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82608300
53Hedgehog signaling pathway_Homo sapiens_hsa043400.81946408
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81712455
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78490848
56Oxidative phosphorylation_Homo sapiens_hsa001900.77283673
57Pentose phosphate pathway_Homo sapiens_hsa000300.75250517
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72230749
59Dorso-ventral axis formation_Homo sapiens_hsa043200.70285439
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69414830
61Cell cycle_Homo sapiens_hsa041100.69374795
62Renin secretion_Homo sapiens_hsa049240.67381136
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63180198
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58357718
65Retinol metabolism_Homo sapiens_hsa008300.58033175
66Glutamatergic synapse_Homo sapiens_hsa047240.57070217
67Galactose metabolism_Homo sapiens_hsa000520.56491990
68Ether lipid metabolism_Homo sapiens_hsa005650.56004539
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55380084
70Alzheimers disease_Homo sapiens_hsa050100.54985349
71Serotonergic synapse_Homo sapiens_hsa047260.54770815
72Ovarian steroidogenesis_Homo sapiens_hsa049130.54224996
73Metabolic pathways_Homo sapiens_hsa011000.54147681
74Insulin secretion_Homo sapiens_hsa049110.53467524
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50002568
76Non-homologous end-joining_Homo sapiens_hsa034500.49510018
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48670703
78One carbon pool by folate_Homo sapiens_hsa006700.48547682
79ABC transporters_Homo sapiens_hsa020100.46820775
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45493000
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.44642729
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.42635280
83Fanconi anemia pathway_Homo sapiens_hsa034600.41918575
84Butanoate metabolism_Homo sapiens_hsa006500.41370731
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40318188
86Proteasome_Homo sapiens_hsa030500.38474199
87cAMP signaling pathway_Homo sapiens_hsa040240.38290274
88Long-term depression_Homo sapiens_hsa047300.38185337
89Mineral absorption_Homo sapiens_hsa049780.38113306
90Arachidonic acid metabolism_Homo sapiens_hsa005900.36893818
91Lysine degradation_Homo sapiens_hsa003100.34774723
92Alcoholism_Homo sapiens_hsa050340.33030170
93Bile secretion_Homo sapiens_hsa049760.32373580
94Tight junction_Homo sapiens_hsa045300.32247791
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29806919
96Cocaine addiction_Homo sapiens_hsa050300.28551408
97Tyrosine metabolism_Homo sapiens_hsa003500.28400416
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27930373
99Glutathione metabolism_Homo sapiens_hsa004800.26210069
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.23729031

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