TRIM74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.27962163
2cellular response to exogenous dsRNA (GO:0071360)4.67211048
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.60982463
4positive thymic T cell selection (GO:0045059)4.56867457
5negative regulation of B cell apoptotic process (GO:0002903)4.46248796
6positive regulation of granulocyte differentiation (GO:0030854)4.45220979
7positive regulation of B cell differentiation (GO:0045579)4.36890334
8chaperone mediated protein folding requiring cofactor (GO:0051085)4.20429008
9cellular response to interferon-beta (GO:0035458)4.12653461
10response to muramyl dipeptide (GO:0032495)4.03179771
11definitive hemopoiesis (GO:0060216)3.89379743
12mannose metabolic process (GO:0006013)3.88784246
13response to peptidoglycan (GO:0032494)3.86738567
14response to protozoan (GO:0001562)3.83714342
15defense response to protozoan (GO:0042832)3.83516257
16UV protection (GO:0009650)3.75967170
17dosage compensation (GO:0007549)3.71646379
18response to interferon-beta (GO:0035456)3.71274845
19thrombin receptor signaling pathway (GO:0070493)3.66910897
20purine nucleotide salvage (GO:0032261)3.63917300
21autophagic vacuole fusion (GO:0000046)3.60663852
22negative thymic T cell selection (GO:0045060)3.58480775
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52645470
24regulation of hydrogen peroxide metabolic process (GO:0010310)3.51098352
25protein polyglutamylation (GO:0018095)3.46577572
26regulation of erythrocyte differentiation (GO:0045646)3.46286380
27phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.44191562
28pentose metabolic process (GO:0019321)3.38770832
29regulation of B cell apoptotic process (GO:0002902)3.37192821
30regulation of respiratory burst (GO:0060263)3.27908076
31oligosaccharide catabolic process (GO:0009313)3.26438384
32sleep (GO:0030431)3.25325854
33thymic T cell selection (GO:0045061)3.24410930
34regulation of B cell differentiation (GO:0045577)3.23095225
35negative T cell selection (GO:0043383)3.23038584
36regulation of granulocyte differentiation (GO:0030852)3.23035994
37mast cell degranulation (GO:0043303)3.23026097
38mast cell activation involved in immune response (GO:0002279)3.23026097
39peptidyl-arginine omega-N-methylation (GO:0035247)3.22632038
40leukocyte aggregation (GO:0070486)3.17581035
41imidazole-containing compound metabolic process (GO:0052803)3.15331391
42phosphatidylglycerol biosynthetic process (GO:0006655)3.14225343
43purinergic nucleotide receptor signaling pathway (GO:0035590)3.10222723
44pinocytosis (GO:0006907)3.10151772
45positive T cell selection (GO:0043368)3.09806774
46immunoglobulin mediated immune response (GO:0016064)3.09217546
47antigen processing and presentation of endogenous antigen (GO:0019883)3.05425990
48regulation of antigen processing and presentation (GO:0002577)3.03146378
49DNA deamination (GO:0045006)2.97783518
50histone H2A acetylation (GO:0043968)2.97464610
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92530324
52response to gravity (GO:0009629)2.90940573
53organelle membrane fusion (GO:0090174)2.89212943
54nucleotide salvage (GO:0043173)2.89007607
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84997445
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84997445
57peptidyl-lysine trimethylation (GO:0018023)2.84429182
58endothelium development (GO:0003158)2.82534230
59regulation of interleukin-6 biosynthetic process (GO:0045408)2.81605503
60negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81371941
61grooming behavior (GO:0007625)2.78249201
62mucosal-associated lymphoid tissue development (GO:0048537)2.75063614
63Peyers patch development (GO:0048541)2.75063614
64estrogen biosynthetic process (GO:0006703)2.74094470
65cellular hyperosmotic response (GO:0071474)2.74046258
66glycosphingolipid catabolic process (GO:0046479)2.73500338
67seminiferous tubule development (GO:0072520)2.73085374
68positive regulation of gamma-delta T cell activation (GO:0046645)2.71838231
69T cell migration (GO:0072678)2.66137468
70regulation of penile erection (GO:0060405)2.65185518
71mast cell activation (GO:0045576)2.65024831
72peptidyl-arginine methylation (GO:0018216)2.64570398
73peptidyl-arginine N-methylation (GO:0035246)2.64570398
74response to exogenous dsRNA (GO:0043330)2.59940466
75GDP-mannose metabolic process (GO:0019673)2.58657465
76DNA strand renaturation (GO:0000733)2.58548014
77negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58017452
78valine metabolic process (GO:0006573)2.57622795
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56892186
80B cell receptor signaling pathway (GO:0050853)2.56417416
81positive regulation of antigen processing and presentation (GO:0002579)2.55113720
82branched-chain amino acid catabolic process (GO:0009083)2.54655775
83positive regulation of protein kinase C signaling (GO:0090037)2.54542188
84cellular response to dsRNA (GO:0071359)2.50560551
85actin nucleation (GO:0045010)2.50432410
86histone H3-K9 methylation (GO:0051567)2.50223421
87positive regulation of erythrocyte differentiation (GO:0045648)2.49450408
88purine-containing compound salvage (GO:0043101)2.49435807
89T cell selection (GO:0045058)2.49044296
90axoneme assembly (GO:0035082)2.44594655
91histone H3-K36 demethylation (GO:0070544)2.44188093
92positive regulation of megakaryocyte differentiation (GO:0045654)2.43802767
93glycolipid catabolic process (GO:0019377)2.41466550
94branched-chain amino acid metabolic process (GO:0009081)2.40153491
95B cell mediated immunity (GO:0019724)2.39105410
96hyaluronan catabolic process (GO:0030214)2.38354974
97aggressive behavior (GO:0002118)2.37440292
98glutathione biosynthetic process (GO:0006750)2.36731253
99nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.36421431
100viral mRNA export from host cell nucleus (GO:0046784)2.33181485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.16236960
2VDR_21846776_ChIP-Seq_THP-1_Human3.38692618
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02394686
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.96065811
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84734521
6* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.51512469
7MYC_22102868_ChIP-Seq_BL_Human2.49155653
8ELF1_20517297_ChIP-Seq_JURKAT_Human2.29790674
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27976285
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23573577
11VDR_24763502_ChIP-Seq_THP-1_Human2.16042157
12SCL_19346495_ChIP-Seq_HPC-7_Human2.15521118
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13978335
14CIITA_25753668_ChIP-Seq_RAJI_Human1.99857652
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92821885
16UTX_26944678_Chip-Seq_JUKART_Human1.91084598
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89801264
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88092385
19BCL6_27268052_Chip-Seq_Bcells_Human1.86034124
20MAF_26560356_Chip-Seq_TH1_Human1.85266435
21P68_20966046_ChIP-Seq_HELA_Human1.83363381
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81670964
23LXR_22292898_ChIP-Seq_THP-1_Human1.76587029
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76048703
25MAF_26560356_Chip-Seq_TH2_Human1.75802346
26MYB_26560356_Chip-Seq_TH2_Human1.74693147
27BCOR_27268052_Chip-Seq_Bcells_Human1.74678010
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74200501
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74075743
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72528386
31SPI1_23547873_ChIP-Seq_NB4_Human1.70866477
32XRN2_22483619_ChIP-Seq_HELA_Human1.70311416
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69928612
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63805831
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60289775
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56951673
37E2F1_20622854_ChIP-Seq_HELA_Human1.55289675
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53935651
39PHF8_20622854_ChIP-Seq_HELA_Human1.50814375
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47406889
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.46929461
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.45772692
43TCF7_22412390_ChIP-Seq_EML_Mouse1.44646247
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44376217
45GABP_19822575_ChIP-Seq_HepG2_Human1.44201788
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42569641
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41842737
48FOXP3_21729870_ChIP-Seq_TREG_Human1.41774181
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41339153
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38559309
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38323869
52MYB_26560356_Chip-Seq_TH1_Human1.36993708
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36817620
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34152069
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34069147
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.33812929
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33646295
58FOXP1_21924763_ChIP-Seq_HESCs_Human1.33392287
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33273474
60KDM2B_26808549_Chip-Seq_DND41_Human1.32420528
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.31557101
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31483609
63ZNF263_19887448_ChIP-Seq_K562_Human1.30714037
64KDM5A_27292631_Chip-Seq_BREAST_Human1.30638421
65VDR_23849224_ChIP-Seq_CD4+_Human1.30445980
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.29546510
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.29508312
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28268488
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27543078
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.27247192
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26955011
72SMC4_20622854_ChIP-Seq_HELA_Human1.25487351
73NCOR1_26117541_ChIP-Seq_K562_Human1.24167301
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23346662
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.23208233
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22660313
77P300_27268052_Chip-Seq_Bcells_Human1.21888606
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21380742
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.21314590
80CTCF_21964334_Chip-Seq_Bcells_Human1.21287816
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20492725
82SPI1_23127762_ChIP-Seq_K562_Human1.19746456
83GATA3_27048872_Chip-Seq_THYMUS_Human1.18992802
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.18981547
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17096972
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16931723
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.15836060
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.15737582
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12512092
90GATA1_19941826_ChIP-Seq_K562_Human1.12136277
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11927860
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11330496
93RUNX_20019798_ChIP-Seq_JUKART_Human1.10284408
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09613061
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09255906
96SPI1_20517297_ChIP-Seq_HL60_Human1.08814019
97GATA1_22025678_ChIP-Seq_K562_Human1.08197307
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07921564
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07235599
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06542123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.00098216
2MP0003436_decreased_susceptibility_to3.49801719
3MP0005058_abnormal_lysosome_morphology2.88969311
4MP0005464_abnormal_platelet_physiology2.87611987
5MP0000372_irregular_coat_pigmentation2.87396426
6MP0003172_abnormal_lysosome_physiology2.65295374
7MP0009278_abnormal_bone_marrow2.60613170
8MP0002132_abnormal_respiratory_system2.58578713
9MP0001545_abnormal_hematopoietic_system2.55083215
10MP0005397_hematopoietic_system_phenotyp2.55083215
11MP0001986_abnormal_taste_sensitivity2.47897783
12MP0002396_abnormal_hematopoietic_system2.38863553
13MP0001835_abnormal_antigen_presentation2.33178304
14MP0005075_abnormal_melanosome_morpholog2.10392835
15MP0008260_abnormal_autophagy2.06218640
16MP0002148_abnormal_hypersensitivity_rea2.04682293
17MP0000465_gastrointestinal_hemorrhage2.03634277
18MP0002398_abnormal_bone_marrow1.91625874
19MP0003191_abnormal_cellular_cholesterol1.88793053
20MP0002419_abnormal_innate_immunity1.87913702
21MP0005025_abnormal_response_to1.86069631
22MP0002420_abnormal_adaptive_immunity1.77771933
23MP0004782_abnormal_surfactant_physiolog1.75478450
24MP0003763_abnormal_thymus_physiology1.74206198
25MP0002723_abnormal_immune_serum1.73131381
26MP0001819_abnormal_immune_cell1.73012400
27MP0005000_abnormal_immune_tolerance1.72020839
28MP0009697_abnormal_copulation1.70000458
29MP0000689_abnormal_spleen_morphology1.64110594
30MP0002452_abnormal_antigen_presenting1.61947820
31MP0003183_abnormal_peptide_metabolism1.61499966
32MP0002722_abnormal_immune_system1.59156552
33MP0001800_abnormal_humoral_immune1.57431465
34MP0000716_abnormal_immune_system1.53987579
35MP0002405_respiratory_system_inflammati1.47299275
36MP0004808_abnormal_hematopoietic_stem1.46033301
37MP0002429_abnormal_blood_cell1.44592286
38MP0005646_abnormal_pituitary_gland1.42989842
39MP0003806_abnormal_nucleotide_metabolis1.40253467
40MP0001790_abnormal_immune_system1.38462565
41MP0005387_immune_system_phenotype1.38462565
42MP0005409_darkened_coat_color1.37352024
43MP0010155_abnormal_intestine_physiology1.36426761
44MP0005220_abnormal_exocrine_pancreas1.35946243
45MP0003303_peritoneal_inflammation1.34191366
46MP0002019_abnormal_tumor_incidence1.33690103
47MP0005360_urolithiasis1.30280693
48MP0001853_heart_inflammation1.23144090
49MP0000703_abnormal_thymus_morphology1.20824554
50MP0008007_abnormal_cellular_replicative1.19519981
51MP0005410_abnormal_fertilization1.18587381
52MP0009765_abnormal_xenobiotic_induced1.16651848
53MP0009333_abnormal_splenocyte_physiolog1.15797610
54MP0003866_abnormal_defecation1.15205709
55MP0008469_abnormal_protein_level1.14947144
56MP0009764_decreased_sensitivity_to1.12384256
57MP0000685_abnormal_immune_system1.09459117
58MP0006036_abnormal_mitochondrial_physio1.07278169
59MP0001533_abnormal_skeleton_physiology1.05955501
60MP0004185_abnormal_adipocyte_glucose1.02668386
61MP0000013_abnormal_adipose_tissue1.01164033
62MP0008058_abnormal_DNA_repair1.00796980
63MP0003656_abnormal_erythrocyte_physiolo1.00392302
64MP0005365_abnormal_bile_salt0.96208264
65MP0000681_abnormal_thyroid_gland0.95915946
66MP0005174_abnormal_tail_pigmentation0.95852959
67MP0009785_altered_susceptibility_to0.95498604
68MP0009763_increased_sensitivity_to0.94583846
69MP0001873_stomach_inflammation0.92672626
70MP0006054_spinal_hemorrhage0.91321167
71MP0004947_skin_inflammation0.91116278
72MP0000358_abnormal_cell_content/0.88382071
73MP0001845_abnormal_inflammatory_respons0.88310806
74MP0008995_early_reproductive_senescence0.86643795
75MP0005330_cardiomyopathy0.84126714
76MP0005377_hearing/vestibular/ear_phenot0.83154429
77MP0003878_abnormal_ear_physiology0.83154429
78MP0004147_increased_porphyrin_level0.82464401
79MP0000383_abnormal_hair_follicle0.81318936
80MP0003718_maternal_effect0.80906255
81MP0009384_cardiac_valve_regurgitation0.80251789
82MP0000015_abnormal_ear_pigmentation0.79436059
83MP0002160_abnormal_reproductive_system0.79193304
84MP0002249_abnormal_larynx_morphology0.79097545
85MP0009379_abnormal_foot_pigmentation0.79018885
86MP0000598_abnormal_liver_morphology0.77289529
87MP0008873_increased_physiological_sensi0.76578686
88MP0001764_abnormal_homeostasis0.75687502
89MP0003300_gastrointestinal_ulcer0.75270993
90MP0006292_abnormal_olfactory_placode0.75229124
91MP0005171_absent_coat_pigmentation0.72180588
92MP0002282_abnormal_trachea_morphology0.71080152
93MP0000490_abnormal_crypts_of0.70360053
94MP0000858_altered_metastatic_potential0.70240636
95MP0005671_abnormal_response_to0.69611710
96MP0002933_joint_inflammation0.68760194
97MP0003724_increased_susceptibility_to0.65691622
98MP0006035_abnormal_mitochondrial_morpho0.64714358
99MP0008961_abnormal_basal_metabolism0.64360835
100MP0009642_abnormal_blood_homeostasis0.62539269

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)5.07889259
2Elevated erythrocyte sedimentation rate (HP:0003565)4.83902157
3Prolonged bleeding time (HP:0003010)4.59375386
4Attenuation of retinal blood vessels (HP:0007843)4.04943229
5Panhypogammaglobulinemia (HP:0003139)3.96398704
6Decreased central vision (HP:0007663)3.25613236
7Epistaxis (HP:0000421)3.09705871
8Seborrheic dermatitis (HP:0001051)3.04813942
9Myositis (HP:0100614)2.98848586
10Recurrent fungal infections (HP:0002841)2.95637821
11Chronic mucocutaneous candidiasis (HP:0002728)2.84853278
12Recurrent cutaneous fungal infections (HP:0011370)2.84853278
13Decreased electroretinogram (ERG) amplitude (HP:0000654)2.83660589
14Microvesicular hepatic steatosis (HP:0001414)2.82746727
15Muscle stiffness (HP:0003552)2.80846039
16Obstructive lung disease (HP:0006536)2.71339548
17Chronic obstructive pulmonary disease (HP:0006510)2.71339548
18Abnormal glycosylation (HP:0012345)2.70727897
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70727897
20Abnormal protein N-linked glycosylation (HP:0012347)2.70727897
21Abnormal protein glycosylation (HP:0012346)2.70727897
22Petechiae (HP:0000967)2.67330334
23Hypertensive crisis (HP:0100735)2.59537077
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59081171
25Abnormality of polysaccharide metabolism (HP:0011012)2.59081171
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59081171
27Brushfield spots (HP:0001088)2.58929373
28Abnormality of the prostate (HP:0008775)2.55293792
29Hemorrhage of the eye (HP:0011885)2.54637150
30Aplastic anemia (HP:0001915)2.49730925
31Acute lymphatic leukemia (HP:0006721)2.48901650
32Basal cell carcinoma (HP:0002671)2.48837428
33Thrombocytosis (HP:0001894)2.46472730
34Agammaglobulinemia (HP:0004432)2.44769054
35Testicular atrophy (HP:0000029)2.42474138
36Dysautonomia (HP:0002459)2.42005190
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41252204
38Dicarboxylic aciduria (HP:0003215)2.41252204
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.40628522
40Granulocytopenia (HP:0001913)2.39133723
41Abnormality of fatty-acid metabolism (HP:0004359)2.37399751
42Progressive microcephaly (HP:0000253)2.34415215
43Spastic paraparesis (HP:0002313)2.32660500
44Increased IgE level (HP:0003212)2.31610573
453-Methylglutaconic aciduria (HP:0003535)2.31118623
46Abnormality of B cell number (HP:0010975)2.30998934
47Joint stiffness (HP:0001387)2.30928168
48Joint hemorrhage (HP:0005261)2.30399016
49Urinary glycosaminoglycan excretion (HP:0003541)2.30177046
50Mucopolysacchariduria (HP:0008155)2.30177046
51Dysostosis multiplex (HP:0000943)2.28177732
52Type I transferrin isoform profile (HP:0003642)2.27544990
53Pustule (HP:0200039)2.21459970
54Chest pain (HP:0100749)2.20471631
55Abnormality of liposaccharide metabolism (HP:0010968)2.19065667
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.19065667
57Abnormality of glycolipid metabolism (HP:0010969)2.19065667
58Increased serum ferritin (HP:0003281)2.19036293
59Abnormal biliary tract physiology (HP:0012439)2.18361381
60Bile duct proliferation (HP:0001408)2.18361381
61Chronic otitis media (HP:0000389)2.17245702
62Mesangial abnormality (HP:0001966)2.15753319
63Abnormality of macular pigmentation (HP:0008002)2.15321320
64Recurrent viral infections (HP:0004429)2.14931529
65Prostate neoplasm (HP:0100787)2.14887547
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13443242
67Increased muscle lipid content (HP:0009058)2.11415178
68Thin bony cortex (HP:0002753)2.10140005
69Bony spicule pigmentary retinopathy (HP:0007737)2.09526045
70Abnormality of iron homeostasis (HP:0011031)2.08016829
71Prolonged partial thromboplastin time (HP:0003645)2.06205862
72Failure to thrive in infancy (HP:0001531)2.05236059
73Hepatosplenomegaly (HP:0001433)2.04451267
74Cellulitis (HP:0100658)2.02053703
75B lymphocytopenia (HP:0010976)2.01641162
76Truncus arteriosus (HP:0001660)2.00747982
77Progressive muscle weakness (HP:0003323)2.00713351
78Abnormality of male internal genitalia (HP:0000022)1.97705706
79Thoracic kyphosis (HP:0002942)1.91820006
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91630505
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91422355
82Abnormality of the peritoneum (HP:0002585)1.89468776
83Vacuolated lymphocytes (HP:0001922)1.88312048
84Meningitis (HP:0001287)1.88142842
85Annular pancreas (HP:0001734)1.88092786
86Encephalitis (HP:0002383)1.87970416
87Autoimmune hemolytic anemia (HP:0001890)1.87022298
88Abnormality of the costochondral junction (HP:0000919)1.86806559
89Hepatocellular necrosis (HP:0001404)1.85283298
90Cheilitis (HP:0100825)1.85217978
91Episodic fever (HP:0001954)1.84953637
92Epiphyseal stippling (HP:0010655)1.84558118
93Recurrent skin infections (HP:0001581)1.83933878
94Progressive external ophthalmoplegia (HP:0000590)1.83613673
95Abnormality of transition element cation homeostasis (HP:0011030)1.83202567
96Delayed epiphyseal ossification (HP:0002663)1.82883964
97Fatigue (HP:0012378)1.82748544
98J-shaped sella turcica (HP:0002680)1.82512651
99Abnormal epiphyseal ossification (HP:0010656)1.82156531
100Abnormal enzyme/coenzyme activity (HP:0012379)1.79162593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.30742001
2VRK23.27528347
3MAP2K33.19213413
4MAP4K13.15441184
5SRPK13.01306503
6BCKDK2.97037581
7KIT2.45067172
8MAPK152.43427427
9TBK12.39910691
10TAOK32.25762668
11FLT32.18694773
12TESK22.15776360
13TNK22.06795048
14SMG11.95575997
15PRPF4B1.93970082
16FES1.88726292
17GRK61.84293759
18SCYL21.76349221
19NUAK11.66660372
20CSF1R1.58148175
21IRAK21.57434778
22PIM21.56929674
23ZAP701.54006994
24MAP3K141.52781130
25MAP3K111.52526459
26IKBKB1.51810233
27STK161.48296593
28BTK1.47078739
29MAP2K21.39848951
30TRIB31.35509245
31SYK1.33709375
32MAP2K61.31936993
33TEC1.21488655
34IRAK11.14521849
35JAK31.12578977
36TAOK21.10255343
37LRRK21.08487571
38ITK1.03105938
39PRKD21.00816327
40IKBKE0.99920194
41TXK0.97515544
42HCK0.97306989
43BLK0.88742847
44CCNB10.86840913
45VRK10.83597291
46CDK90.81580463
47EIF2AK20.81172950
48LCK0.79346124
49MAP3K60.78266572
50RPS6KC10.78157946
51RPS6KL10.78157946
52BMX0.77239959
53WNK40.76746461
54PRKCQ0.74176169
55PKN20.73593460
56EPHB10.73347745
57ATR0.72903258
58RPS6KA60.72864639
59MAP3K130.72460384
60RPS6KA20.67290307
61NME20.67280294
62SIK30.66556038
63KDR0.66536089
64RPS6KA50.65659879
65SIK10.63747478
66MAPK110.62913327
67MATK0.59346746
68RIPK40.58963457
69MAPK70.58732837
70MAP2K40.58047956
71LYN0.56869122
72CDK70.56005204
73MAPK30.55841726
74CDK120.54497696
75TYK20.48639439
76ADRBK10.48399687
77SIK20.47860928
78RPS6KA10.47739423
79MARK20.47613819
80CHUK0.46740432
81DYRK1B0.46658106
82PRKCI0.46597201
83MAP3K10.46530742
84PDPK10.44604654
85RAF10.44345900
86IRAK40.44196308
87CLK10.43719186
88CDK40.41497903
89CAMKK10.38831679
90MTOR0.38265979
91PKN10.37522759
92CSNK1G30.35636080
93PDK10.34154862
94MAPK40.34058460
95ARAF0.33855956
96BMPR1B0.33657702
97PASK0.32553847
98MAP3K70.31863062
99MARK30.31060248
100HIPK20.30331694

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005115.62916193
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.04886797
3Allograft rejection_Homo sapiens_hsa053302.91477038
4Asthma_Homo sapiens_hsa053102.85752098
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.65876425
6Leishmaniasis_Homo sapiens_hsa051402.32434205
7Type I diabetes mellitus_Homo sapiens_hsa049402.32383416
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31191488
9Autoimmune thyroid disease_Homo sapiens_hsa053202.27595927
10Graft-versus-host disease_Homo sapiens_hsa053322.09578874
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97411962
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93307723
13Base excision repair_Homo sapiens_hsa034101.89125642
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87482770
15Primary immunodeficiency_Homo sapiens_hsa053401.76552992
16Herpes simplex infection_Homo sapiens_hsa051681.75204421
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74597391
18Sulfur relay system_Homo sapiens_hsa041221.60623449
19Hematopoietic cell lineage_Homo sapiens_hsa046401.56656091
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56631253
21Antigen processing and presentation_Homo sapiens_hsa046121.47591203
22Sphingolipid metabolism_Homo sapiens_hsa006001.44004310
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41880759
24Ribosome_Homo sapiens_hsa030101.40073345
25Staphylococcus aureus infection_Homo sapiens_hsa051501.37994337
26RNA polymerase_Homo sapiens_hsa030201.34486622
27Acute myeloid leukemia_Homo sapiens_hsa052211.32295378
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22352041
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21469552
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21222088
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16082132
32Peroxisome_Homo sapiens_hsa041461.13020692
33Influenza A_Homo sapiens_hsa051641.09889001
34Arachidonic acid metabolism_Homo sapiens_hsa005901.06495146
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06355137
36Butanoate metabolism_Homo sapiens_hsa006501.06061350
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04482613
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04088457
39Spliceosome_Homo sapiens_hsa030400.98437000
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94553338
41Platelet activation_Homo sapiens_hsa046110.91972405
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91440579
43Pyrimidine metabolism_Homo sapiens_hsa002400.89877501
44Fructose and mannose metabolism_Homo sapiens_hsa000510.88368078
45Viral myocarditis_Homo sapiens_hsa054160.87845798
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.87435812
47Pertussis_Homo sapiens_hsa051330.86623391
48RNA transport_Homo sapiens_hsa030130.86027926
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85603759
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84769638
51B cell receptor signaling pathway_Homo sapiens_hsa046620.84543296
52Chemical carcinogenesis_Homo sapiens_hsa052040.82626486
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82510627
54Tuberculosis_Homo sapiens_hsa051520.81675959
55Glycerolipid metabolism_Homo sapiens_hsa005610.81154413
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79943578
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78168729
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76119581
59Lysine degradation_Homo sapiens_hsa003100.76025928
60Hepatitis C_Homo sapiens_hsa051600.71838789
61Epstein-Barr virus infection_Homo sapiens_hsa051690.70592920
62Lysosome_Homo sapiens_hsa041420.70049951
63Shigellosis_Homo sapiens_hsa051310.69736098
64Fatty acid metabolism_Homo sapiens_hsa012120.68393947
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.67776681
66Rheumatoid arthritis_Homo sapiens_hsa053230.67190088
67Fanconi anemia pathway_Homo sapiens_hsa034600.66911188
68Toxoplasmosis_Homo sapiens_hsa051450.66723814
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.64765022
70Fatty acid degradation_Homo sapiens_hsa000710.64154778
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63273279
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61313208
73Glutathione metabolism_Homo sapiens_hsa004800.60425271
74RNA degradation_Homo sapiens_hsa030180.59010622
75Measles_Homo sapiens_hsa051620.57847156
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56400509
77Homologous recombination_Homo sapiens_hsa034400.53458582
78Legionellosis_Homo sapiens_hsa051340.51973757
79Pentose phosphate pathway_Homo sapiens_hsa000300.51654895
80Osteoclast differentiation_Homo sapiens_hsa043800.50241378
81Carbon metabolism_Homo sapiens_hsa012000.48287790
82Pyruvate metabolism_Homo sapiens_hsa006200.47745299
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47611071
84Vitamin digestion and absorption_Homo sapiens_hsa049770.45463446
85T cell receptor signaling pathway_Homo sapiens_hsa046600.45384455
86Purine metabolism_Homo sapiens_hsa002300.43199602
87Non-homologous end-joining_Homo sapiens_hsa034500.42008204
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41520451
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41456847
90mRNA surveillance pathway_Homo sapiens_hsa030150.41092965
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38428862
92HTLV-I infection_Homo sapiens_hsa051660.37263955
93ABC transporters_Homo sapiens_hsa020100.36904323
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.36902174
95African trypanosomiasis_Homo sapiens_hsa051430.36810791
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35457108
97DNA replication_Homo sapiens_hsa030300.32872066
98Apoptosis_Homo sapiens_hsa042100.32418561
99Inositol phosphate metabolism_Homo sapiens_hsa005620.31720666
100Propanoate metabolism_Homo sapiens_hsa006400.31415640

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