TRIM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)6.87581851
2skeletal muscle contraction (GO:0003009)6.35788775
3substrate-independent telencephalic tangential migration (GO:0021826)6.24673894
4substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.24673894
5dopamine transport (GO:0015872)6.10177686
6peristalsis (GO:0030432)5.60909993
7drug transmembrane transport (GO:0006855)5.48227174
8regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.35870738
9regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.35870738
10lysine metabolic process (GO:0006553)5.18189871
11lysine catabolic process (GO:0006554)5.18189871
12urate metabolic process (GO:0046415)5.09079949
13phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.92582704
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.87900661
15response to muscle activity (GO:0014850)4.87250432
16regulation of relaxation of muscle (GO:1901077)4.81049221
17aminoglycoside antibiotic metabolic process (GO:0030647)4.79015853
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.67790330
19striated muscle contraction (GO:0006941)4.64678793
20tryptophan catabolic process (GO:0006569)4.64178620
21indole-containing compound catabolic process (GO:0042436)4.64178620
22indolalkylamine catabolic process (GO:0046218)4.64178620
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.63934623
24regulation of neurotransmitter uptake (GO:0051580)4.63146039
25striatum development (GO:0021756)4.62052916
26antigen processing and presentation of endogenous antigen (GO:0019883)4.56878339
27glyoxylate metabolic process (GO:0046487)4.55462555
28quaternary ammonium group transport (GO:0015697)4.45999352
29desmosome organization (GO:0002934)4.39275065
30aromatic amino acid family catabolic process (GO:0009074)4.38173143
31maternal behavior (GO:0042711)4.29629135
32actin filament-based movement (GO:0030048)4.29581763
33tryptophan metabolic process (GO:0006568)4.29443286
34drug transport (GO:0015893)4.29061587
35myofibril assembly (GO:0030239)4.28462717
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.25578356
37carnitine transport (GO:0015879)4.23575828
38amino-acid betaine transport (GO:0015838)4.23575828
39skeletal muscle fiber development (GO:0048741)4.22934441
40kynurenine metabolic process (GO:0070189)4.21103096
41behavioral response to cocaine (GO:0048148)4.20606008
42organic cation transport (GO:0015695)4.20503018
43negative regulation of cAMP-mediated signaling (GO:0043951)4.15668803
44amino-acid betaine metabolic process (GO:0006577)4.14936262
45L-phenylalanine catabolic process (GO:0006559)4.13104829
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.13104829
47cerebellar granule cell differentiation (GO:0021707)4.10202385
48cell proliferation in forebrain (GO:0021846)4.05358996
49muscle contraction (GO:0006936)4.04655398
50short-chain fatty acid metabolic process (GO:0046459)4.04076201
51adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.02534676
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.02485150
53L-phenylalanine metabolic process (GO:0006558)4.02485150
54carnitine metabolic process (GO:0009437)4.01553006
55pyrimidine ribonucleoside catabolic process (GO:0046133)4.01165601
56parental behavior (GO:0060746)3.98902128
57prepulse inhibition (GO:0060134)3.97749177
58catecholamine transport (GO:0051937)3.95576330
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93718090
60myotube cell development (GO:0014904)3.93392269
61drug catabolic process (GO:0042737)3.91991929
62fatty acid beta-oxidation (GO:0006635)3.89162495
63valine metabolic process (GO:0006573)3.88545719
64glycogen catabolic process (GO:0005980)3.88376524
65cardiac muscle hypertrophy (GO:0003300)3.86467462
66phasic smooth muscle contraction (GO:0014821)3.79659766
67neuronal action potential (GO:0019228)3.79223081
68exogenous drug catabolic process (GO:0042738)3.75655522
69auditory receptor cell stereocilium organization (GO:0060088)3.75640028
702-oxoglutarate metabolic process (GO:0006103)3.74791368
71homocysteine metabolic process (GO:0050667)3.74235151
72cysteine metabolic process (GO:0006534)3.73893627
73aspartate family amino acid catabolic process (GO:0009068)3.73757577
74transmission of nerve impulse (GO:0019226)3.73157441
75branched-chain amino acid metabolic process (GO:0009081)3.72872795
76regulation of secondary heart field cardioblast proliferation (GO:0003266)3.72535385
77regulation of cardioblast proliferation (GO:0003264)3.72535385
78muscle system process (GO:0003012)3.71459145
79response to inactivity (GO:0014854)3.71303806
80striated muscle hypertrophy (GO:0014897)3.67337165
81phosphate ion transport (GO:0006817)3.67137185
82carnitine shuttle (GO:0006853)3.63091881
83mating behavior (GO:0007617)3.60422244
84lens fiber cell development (GO:0070307)3.57258831
85ubiquinone biosynthetic process (GO:0006744)3.56783808
86glucan catabolic process (GO:0009251)3.56664213
87synaptic transmission, dopaminergic (GO:0001963)3.55722325
88carnitine transmembrane transport (GO:1902603)3.55458182
89cardiac muscle hypertrophy in response to stress (GO:0014898)3.55383310
90muscle hypertrophy in response to stress (GO:0003299)3.55383310
91cardiac muscle adaptation (GO:0014887)3.55383310
92fatty acid oxidation (GO:0019395)3.52510789
93serine family amino acid catabolic process (GO:0009071)3.51944432
94response to mercury ion (GO:0046689)3.51821864
95positive regulation of potassium ion transport (GO:0043268)3.51462000
96cytidine metabolic process (GO:0046087)3.51414786
97cytidine catabolic process (GO:0006216)3.51414786
98cytidine deamination (GO:0009972)3.51414786
99striated muscle adaptation (GO:0014888)3.48578149
100maturation of 5.8S rRNA (GO:0000460)3.47487438
101lipid oxidation (GO:0034440)3.44154420
102regulation of cell communication by electrical coupling (GO:0010649)3.43719225
103muscle fiber development (GO:0048747)3.42332422
104acetyl-CoA metabolic process (GO:0006084)3.39817313
105positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.38845061
106skeletal muscle adaptation (GO:0043501)3.38611547
107dentate gyrus development (GO:0021542)3.37739952
108ubiquinone metabolic process (GO:0006743)3.36813436
109bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36774531
110fatty acid transmembrane transport (GO:1902001)3.36548122
111tricarboxylic acid metabolic process (GO:0072350)3.34623125
112regulation of skeletal muscle contraction (GO:0014819)3.30592574
113adult walking behavior (GO:0007628)3.30329030
114cellular polysaccharide catabolic process (GO:0044247)3.27262917
115dicarboxylic acid biosynthetic process (GO:0043650)3.26953445
116regulation of glucokinase activity (GO:0033131)3.26684212
117regulation of hexokinase activity (GO:1903299)3.26684212
118fatty acid catabolic process (GO:0009062)3.24290760
119branched-chain amino acid catabolic process (GO:0009083)3.23869312
120cardiac muscle contraction (GO:0060048)3.23612728
121neuron fate determination (GO:0048664)3.22971748
122glucan biosynthetic process (GO:0009250)3.22244460
123glycogen biosynthetic process (GO:0005978)3.22244460
124regulation of synaptic transmission, dopaminergic (GO:0032225)3.22000004
125phosphate ion transmembrane transport (GO:0035435)3.21317285
126cellular modified amino acid catabolic process (GO:0042219)3.20101445
127muscle hypertrophy (GO:0014896)3.19794150
128biotin metabolic process (GO:0006768)3.17432980
129neuronal action potential propagation (GO:0019227)3.16327460
130indolalkylamine metabolic process (GO:0006586)3.15306180
131actin-myosin filament sliding (GO:0033275)3.15299580
132muscle filament sliding (GO:0030049)3.15299580
133cellular biogenic amine catabolic process (GO:0042402)3.14014197
134amine catabolic process (GO:0009310)3.14014197
135aromatic amino acid family metabolic process (GO:0009072)3.12670578
136monocarboxylic acid catabolic process (GO:0072329)3.12433112
137regulation of actin filament-based movement (GO:1903115)3.10945551
138regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10000147
139benzene-containing compound metabolic process (GO:0042537)3.09269104
140sex differentiation (GO:0007548)3.06413079
141ethanol oxidation (GO:0006069)3.06273468
142phosphate ion homeostasis (GO:0055062)3.05442752
143trivalent inorganic anion homeostasis (GO:0072506)3.05442752
144neuromuscular synaptic transmission (GO:0007274)3.03487856
145antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02726473
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02726473
147alpha-amino acid catabolic process (GO:1901606)3.02655843
148skeletal muscle tissue development (GO:0007519)3.01424397
149response to phenylpropanoid (GO:0080184)3.00630069
150regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.98970751
151muscle cell cellular homeostasis (GO:0046716)2.98083841
152long term synaptic depression (GO:0060292)2.96866107
153polysaccharide catabolic process (GO:0000272)2.96398252
154actomyosin structure organization (GO:0031032)2.92069225
155vitamin D metabolic process (GO:0042359)2.90102345
156asymmetric protein localization (GO:0008105)2.89067617
157hemidesmosome assembly (GO:0031581)2.87882573
158B cell receptor signaling pathway (GO:0050853)2.87763896
159positive regulation of synapse assembly (GO:0051965)2.87059781
160regulation of dopamine metabolic process (GO:0042053)2.87009077
161regulation of catecholamine metabolic process (GO:0042069)2.87009077
162cellular amino acid catabolic process (GO:0009063)2.84922633
163cellular ketone body metabolic process (GO:0046950)2.83903377
164bile acid biosynthetic process (GO:0006699)2.83377988
165sarcomere organization (GO:0045214)2.83051060
166cell morphogenesis involved in neuron differentiation (GO:0048667)2.82448580
167muscle adaptation (GO:0043500)2.82439503
168organic acid catabolic process (GO:0016054)2.81579658
169carboxylic acid catabolic process (GO:0046395)2.81579658
170fructose metabolic process (GO:0006000)2.81282550
171heart process (GO:0003015)2.80371294
172heart contraction (GO:0060047)2.80371294
173quinone biosynthetic process (GO:1901663)2.79093179
174cardiac myofibril assembly (GO:0055003)2.78402951
175creatine metabolic process (GO:0006600)2.78307371
176grooming behavior (GO:0007625)2.78128840
177cellular glucuronidation (GO:0052695)2.77719678
178regulation of membrane repolarization (GO:0060306)2.76984523
179pyrimidine nucleoside catabolic process (GO:0046135)2.76213793
180mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75179611
181actin-mediated cell contraction (GO:0070252)2.70823016
182regulation of cholesterol homeostasis (GO:2000188)2.67780703
183sulfur amino acid catabolic process (GO:0000098)2.65195656
184complement activation, classical pathway (GO:0006958)2.63938045
185phospholipid homeostasis (GO:0055091)2.61997576
186ethanol metabolic process (GO:0006067)2.61338041
187nonribosomal peptide biosynthetic process (GO:0019184)2.59648834
188glucuronate metabolic process (GO:0019585)2.56919637
189uronic acid metabolic process (GO:0006063)2.56919637
190plasma membrane repair (GO:0001778)2.55575661
191positive thymic T cell selection (GO:0045059)2.53916564
192regulation of bile acid biosynthetic process (GO:0070857)2.51554699
193excretion (GO:0007588)2.51053165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.74205613
2EZH2_22144423_ChIP-Seq_EOC_Human4.80065720
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.75910305
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.39376939
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.31465190
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.91978622
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.73007463
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.39001453
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.28714231
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.18708989
11ZNF274_21170338_ChIP-Seq_K562_Hela2.96557473
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.77739070
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.77490637
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.41685915
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37744812
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.29974984
17GBX2_23144817_ChIP-Seq_PC3_Human2.27388243
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10189869
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08696443
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08429848
21GATA1_22025678_ChIP-Seq_K562_Human1.97957524
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.94523080
23IGF1R_20145208_ChIP-Seq_DFB_Human1.93148752
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91654390
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91527894
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89965721
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.89171198
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84252915
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76295840
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75111836
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74621842
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74003232
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.69647140
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.68204822
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.68204822
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66639844
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65891350
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59963935
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.57881550
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56023337
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55160252
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.51909454
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51024052
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49090570
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48158993
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46433508
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44111444
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43055869
49ER_23166858_ChIP-Seq_MCF-7_Human1.42795378
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.41183946
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.40379555
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36606228
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36027154
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34709594
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.34545378
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.32156727
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32002429
58REST_21632747_ChIP-Seq_MESCs_Mouse1.29603584
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28324688
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27225551
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27066002
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26358245
63FUS_26573619_Chip-Seq_HEK293_Human1.25937994
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24952681
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24650310
66AR_25329375_ChIP-Seq_VCAP_Human1.24096458
67* PIAS1_25552417_ChIP-Seq_VCAP_Human1.22661907
68CBP_20019798_ChIP-Seq_JUKART_Human1.21070189
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21070189
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20799532
71AR_21572438_ChIP-Seq_LNCaP_Human1.20700475
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20054464
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19131493
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.18930086
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18043013
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17789477
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.15623235
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.14904074
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14364199
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13421126
81NANOG_19829295_ChIP-Seq_ESCs_Human1.12857345
82SOX2_19829295_ChIP-Seq_ESCs_Human1.12857345
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12428247
84RUNX_20019798_ChIP-Seq_JUKART_Human1.12355600
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12004854
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.11804947
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11712117
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.11523211
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10846064
90* OCT4_20526341_ChIP-Seq_ESCs_Human1.10661703
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10308867
92RNF2_27304074_Chip-Seq_NSC_Mouse1.09338765
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08828859
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08530861
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08476599
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08387799
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.07517835
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07105252
99DROSHA_22980978_ChIP-Seq_HELA_Human1.06166072
100CTCF_27219007_Chip-Seq_Bcells_Human1.05888718
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04939523
102IRF8_21731497_ChIP-ChIP_J774_Mouse1.04722289
103ZNF263_19887448_ChIP-Seq_K562_Human1.03986251
104GATA4_25053715_ChIP-Seq_YYC3_Human1.03892581
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.03290563
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.02961330
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.02386836
108CJUN_26792858_Chip-Seq_BT549_Human1.01612849
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01498905
110NANOG_20526341_ChIP-Seq_ESCs_Human1.01382346
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00767683
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00767683
113TCF4_23295773_ChIP-Seq_U87_Human1.00414867
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00104769
115SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99649963
116MYC_19829295_ChIP-Seq_ESCs_Human0.99069411
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.99025668
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97852922
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97526748
120FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97363116
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.97363116
122* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97342212
123CLOCK_20551151_ChIP-Seq_293T_Human0.96896105
124EGR1_19032775_ChIP-ChIP_M12_Human0.95493602
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95230718
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95005147
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94946196
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94739664
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94719691
130ERA_21632823_ChIP-Seq_H3396_Human0.94680422
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94607392
132P53_21459846_ChIP-Seq_SAOS-2_Human0.94602361
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.94507232
134STAT3_23295773_ChIP-Seq_U87_Human0.94079283
135SRF_21415370_ChIP-Seq_HL-1_Mouse0.93927899
136PHF8_20622853_ChIP-Seq_HELA_Human0.93780708
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93043683
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92413683
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91616104
140AHR_22903824_ChIP-Seq_MCF-7_Human0.91249858
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91189459
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91189459
143* TCF7_22412390_ChIP-Seq_EML_Mouse0.91016224
144* MAF_26560356_Chip-Seq_TH1_Human0.90539501
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90527391
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90402659
147SMAD4_21799915_ChIP-Seq_A2780_Human0.90338231
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90327950
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90214033
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90206227
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90197013
152TP63_23658742_ChIP-Seq_EP156T_Human0.90149057
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.89642366
154EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89291901
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89038880
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88846606
157RACK7_27058665_Chip-Seq_MCF-7_Human0.88671316
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88641522
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87981680
160KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86860485
161* LXR_22292898_ChIP-Seq_THP-1_Human0.86166347
162VDR_24787735_ChIP-Seq_THP-1_Human0.85248832
163NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83924314
164* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83883793
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83740290
166RXR_22108803_ChIP-Seq_LS180_Human0.83723458
167BCAT_22108803_ChIP-Seq_LS180_Human0.83560928
168TP63_22573176_ChIP-Seq_HFKS_Human0.83476638
169HNF4A_19822575_ChIP-Seq_HepG2_Human0.83422220
170NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83104771
171GATA6_25053715_ChIP-Seq_YYC3_Human0.82067923
172P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81866542
173PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81634115
174CEBPB_22108803_ChIP-Seq_LS180_Human0.79495936
175SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77983353
176ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76934952
177GATA6_21074721_ChIP-Seq_CACO-2_Human0.75871811
178KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75751284
179GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74610387
180SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.74371209
181NFE2_27457419_Chip-Seq_LIVER_Mouse0.73954462
182FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73784470
183ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73071977
184LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72946566
185ARNT_22903824_ChIP-Seq_MCF-7_Human0.72376879
186SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70786540
187GATA2_19941826_ChIP-Seq_K562_Human0.70588929
188* MYB_26560356_Chip-Seq_TH1_Human0.69914969
189VDR_22108803_ChIP-Seq_LS180_Human0.69498517
190TCF4_18268006_ChIP-ChIP_LS174T_Human0.69473430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern7.02922354
2MP0005360_urolithiasis4.79634337
3MP0002139_abnormal_hepatobiliary_system3.92535014
4MP0002138_abnormal_hepatobiliary_system3.55577249
5MP0002254_reproductive_system_inflammat3.38237218
6MP0003195_calcinosis3.04385104
7MP0003646_muscle_fatigue2.80349056
8MP0001835_abnormal_antigen_presentation2.65145292
9MP0003136_yellow_coat_color2.61500768
10MP0005085_abnormal_gallbladder_physiolo2.51060466
11MP0005365_abnormal_bile_salt2.47798589
12MP0001790_abnormal_immune_system2.47141905
13MP0005387_immune_system_phenotype2.47141905
14MP0004019_abnormal_vitamin_homeostasis2.46456169
15MP0003252_abnormal_bile_duct2.43870149
16MP0002332_abnormal_exercise_endurance2.40366332
17MP0002837_dystrophic_cardiac_calcinosis2.36599331
18MP0005332_abnormal_amino_acid2.31822852
19MP0004043_abnormal_pH_regulation2.28126722
20MP0008875_abnormal_xenobiotic_pharmacok2.26820824
21MP0009643_abnormal_urine_homeostasis2.11373867
22MP0002796_impaired_skin_barrier2.04055876
23MP0005451_abnormal_body_composition1.97132777
24MP0000685_abnormal_immune_system1.96979725
25MP0000751_myopathy1.91552515
26MP0002234_abnormal_pharynx_morphology1.86869554
27MP0001800_abnormal_humoral_immune1.86720131
28MP0004036_abnormal_muscle_relaxation1.80966087
29MP0002136_abnormal_kidney_physiology1.77929882
30MP0004233_abnormal_muscle_weight1.67821520
31MP0001765_abnormal_ion_homeostasis1.67781703
32MP0000749_muscle_degeneration1.65148281
33MP0004510_myositis1.64276268
34MP0002653_abnormal_ependyma_morphology1.62672391
35MP0005670_abnormal_white_adipose1.58275683
36MP0002108_abnormal_muscle_morphology1.47633058
37MP0010234_abnormal_vibrissa_follicle1.45952656
38MP0004270_analgesia1.45842797
39MP0002638_abnormal_pupillary_reflex1.45539800
40MP0004084_abnormal_cardiac_muscle1.43845890
41MP0003011_delayed_dark_adaptation1.38710491
42MP0005330_cardiomyopathy1.37674162
43MP0001666_abnormal_nutrient_absorption1.36257300
44MP0005666_abnormal_adipose_tissue1.35412578
45MP0004142_abnormal_muscle_tone1.32954300
46MP0004087_abnormal_muscle_fiber1.28075022
47MP0003453_abnormal_keratinocyte_physiol1.26863069
48MP0001756_abnormal_urination1.25842442
49MP0003941_abnormal_skin_development1.24374739
50MP0005501_abnormal_skin_physiology1.23690086
51MP0008961_abnormal_basal_metabolism1.23497767
52MP0003300_gastrointestinal_ulcer1.22502621
53MP0005266_abnormal_metabolism1.21916475
54MP0002060_abnormal_skin_morphology1.21197603
55MP0002452_abnormal_antigen_presenting1.19784945
56MP0005275_abnormal_skin_tensile1.19071772
57MP0002168_other_aberrant_phenotype1.19011973
58MP0005636_abnormal_mineral_homeostasis1.18987610
59MP0005000_abnormal_immune_tolerance1.18195903
60MP0003806_abnormal_nucleotide_metabolis1.16924844
61MP0001853_heart_inflammation1.15425624
62MP0003045_fibrosis1.12582182
63MP0001873_stomach_inflammation1.11938012
64MP0000013_abnormal_adipose_tissue1.10583492
65MP0003191_abnormal_cellular_cholesterol1.10550435
66MP0002102_abnormal_ear_morphology1.10334620
67MP0005584_abnormal_enzyme/coenzyme_acti1.10079145
68MP0001529_abnormal_vocalization1.08698333
69MP0009046_muscle_twitch1.08138669
70MP0004130_abnormal_muscle_cell1.08136398
71MP0009764_decreased_sensitivity_to1.07375675
72MP0001216_abnormal_epidermal_layer1.07322989
73MP0005620_abnormal_muscle_contractility1.06953595
74MP0000609_abnormal_liver_physiology1.06761358
75MP0000383_abnormal_hair_follicle1.06287019
76MP0000747_muscle_weakness1.06126201
77MP0002876_abnormal_thyroid_physiology1.06043826
78MP0004215_abnormal_myocardial_fiber1.04789834
79MP0002166_altered_tumor_susceptibility1.04543581
80MP0000733_abnormal_muscle_development1.04161180
81MP0010329_abnormal_lipoprotein_level1.03920113
82MP0005319_abnormal_enzyme/_coenzyme1.03409366
83MP0003879_abnormal_hair_cell1.02703065
84MP0000750_abnormal_muscle_regeneration1.02632247
85MP0002009_preneoplasia1.02527994
86MP0004381_abnormal_hair_follicle1.01759346
87MP0002118_abnormal_lipid_homeostasis1.00766310
88MP0000579_abnormal_nail_morphology0.99526446
89MP0003137_abnormal_impulse_conducting0.98402760
90MP0003950_abnormal_plasma_membrane0.98295511
91MP0004947_skin_inflammation0.97429723
92MP0002106_abnormal_muscle_physiology0.97159008
93MP0003878_abnormal_ear_physiology0.95437055
94MP0005377_hearing/vestibular/ear_phenot0.95437055
95MP0002928_abnormal_bile_duct0.95365084
96MP0001544_abnormal_cardiovascular_syste0.95351033
97MP0005385_cardiovascular_system_phenoty0.95351033
98MP0001984_abnormal_olfaction0.94585253
99MP0002723_abnormal_immune_serum0.94198494
100MP0005647_abnormal_sex_gland0.92098372
101MP0005423_abnormal_somatic_nervous0.91154820
102MP0001958_emphysema0.90155754
103MP0005551_abnormal_eye_electrophysiolog0.90146602
104MP0008775_abnormal_heart_ventricle0.89934952
105MP0002184_abnormal_innervation0.89691735
106MP0002269_muscular_atrophy0.89592593
107MP0006138_congestive_heart_failure0.89532823
108MP0001346_abnormal_lacrimal_gland0.89251071
109MP0002272_abnormal_nervous_system0.88660751
110MP0009250_abnormal_appendicular_skeleto0.88570495
111MP0002972_abnormal_cardiac_muscle0.88408707
112MP0008872_abnormal_physiological_respon0.87824580
113MP0005375_adipose_tissue_phenotype0.87175923
114MP0002127_abnormal_cardiovascular_syste0.87132283
115MP0003566_abnormal_cell_adhesion0.86464925
116MP0010630_abnormal_cardiac_muscle0.85488686
117MP0005310_abnormal_salivary_gland0.82111527
118MP0001845_abnormal_inflammatory_respons0.81969855
119MP0002148_abnormal_hypersensitivity_rea0.81945594
120MP0000538_abnormal_urinary_bladder0.81810423
121MP0000026_abnormal_inner_ear0.81801908
122MP0000467_abnormal_esophagus_morphology0.81801491
123MP0008469_abnormal_protein_level0.81686588
124MP0004484_altered_response_of0.81661324
125MP0002971_abnormal_brown_adipose0.81176187
126MP0004185_abnormal_adipocyte_glucose0.80926883
127MP0004145_abnormal_muscle_electrophysio0.80676772
128MP0010678_abnormal_skin_adnexa0.80512414
129MP0002420_abnormal_adaptive_immunity0.80164437
130MP0006036_abnormal_mitochondrial_physio0.79378917
131MP0002098_abnormal_vibrissa_morphology0.78458144
132MP0001440_abnormal_grooming_behavior0.78097559
133MP0005369_muscle_phenotype0.77343525
134MP0000377_abnormal_hair_follicle0.76498318
135MP0000955_abnormal_spinal_cord0.75872067
136MP0000759_abnormal_skeletal_muscle0.75754714
137MP0001968_abnormal_touch/_nociception0.74009779
138MP0000372_irregular_coat_pigmentation0.73818977
139MP0004147_increased_porphyrin_level0.73400982
140MP0006276_abnormal_autonomic_nervous0.72205007
141MP0002734_abnormal_mechanical_nocicepti0.71767439
142MP0000230_abnormal_systemic_arterial0.69763834
143MP0002733_abnormal_thermal_nociception0.69674696
144MP0004085_abnormal_heartbeat0.68902542
145MP0002822_catalepsy0.68578668
146MP0000631_abnormal_neuroendocrine_gland0.68471725
147MP0005253_abnormal_eye_physiology0.67726136
148MP0009745_abnormal_behavioral_response0.66391709
149MP0002277_abnormal_respiratory_mucosa0.66126266
150MP0000427_abnormal_hair_cycle0.65667937
151MP0000778_abnormal_nervous_system0.65664720
152MP0009780_abnormal_chondrocyte_physiolo0.65466957
153MP0005174_abnormal_tail_pigmentation0.64895946
154MP0003938_abnormal_ear_development0.64151695
155MP0001485_abnormal_pinna_reflex0.63572371
156MP0002067_abnormal_sensory_capabilities0.63144878
157MP0005084_abnormal_gallbladder_morpholo0.61571432
158MP0002064_seizures0.60834419
159MP0001661_extended_life_span0.60583017
160MP0002078_abnormal_glucose_homeostasis0.58254695
161MP0000613_abnormal_salivary_gland0.58149898
162MP0006072_abnormal_retinal_apoptosis0.56102962
163MP0005171_absent_coat_pigmentation0.55933163
164MP0003283_abnormal_digestive_organ0.55702868
165MP0001970_abnormal_pain_threshold0.55515157
166MP0003635_abnormal_synaptic_transmissio0.50897483
167MP0005645_abnormal_hypothalamus_physiol0.49953000

Predicted human phenotypes

RankGene SetZ-score
1Abnormal finger flexion creases (HP:0006143)4.72577300
2Fibular aplasia (HP:0002990)4.58666758
3Gastrointestinal stroma tumor (HP:0100723)4.47786688
4Distal arthrogryposis (HP:0005684)4.44113751
5Gout (HP:0001997)4.24115213
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.23855177
7Agammaglobulinemia (HP:0004432)4.02663411
8Oligodactyly (hands) (HP:0001180)3.90034742
9Exercise-induced myalgia (HP:0003738)3.90018895
10Hypoplastic pelvis (HP:0008839)3.72443552
11Hyperglycinuria (HP:0003108)3.67056153
12Rimmed vacuoles (HP:0003805)3.61883661
13Right ventricular cardiomyopathy (HP:0011663)3.51333962
14Round ear (HP:0100830)3.49340975
15Ketoacidosis (HP:0001993)3.48680720
16Proximal tubulopathy (HP:0000114)3.46672386
17Muscle hypertrophy of the lower extremities (HP:0008968)3.46210800
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.44158632
19Calf muscle hypertrophy (HP:0008981)3.41567227
20Ulnar deviation of the wrist (HP:0003049)3.40970722
21Hyporeflexia of lower limbs (HP:0002600)3.39783049
22Ketosis (HP:0001946)3.30896293
23Hypokalemic alkalosis (HP:0001949)3.26999690
24Hyperuricemia (HP:0002149)3.26430986
25Increased purine levels (HP:0004368)3.26430986
26Abnormality of chloride homeostasis (HP:0011422)3.22950341
27Aplasia/hypoplasia of the uterus (HP:0008684)3.21646407
28Distal lower limb muscle weakness (HP:0009053)3.19442378
29Colitis (HP:0002583)3.19351164
30Abnormality of the left ventricular outflow tract (HP:0011103)3.18213760
31Subaortic stenosis (HP:0001682)3.18213760
32Split foot (HP:0001839)3.16519271
33Polyuria (HP:0000103)3.15019983
34Abnormality of purine metabolism (HP:0004352)3.14379116
35Muscle fiber splitting (HP:0003555)3.14106043
36Metabolic alkalosis (HP:0200114)3.13889348
37Increased circulating renin level (HP:0000848)3.10558476
38Neck muscle weakness (HP:0000467)3.08073254
39Generalized aminoaciduria (HP:0002909)3.05902164
40Myotonia (HP:0002486)3.04868047
41Ventricular tachycardia (HP:0004756)3.03828681
42Abnormality of glycine metabolism (HP:0010895)3.02701448
43Abnormality of serine family amino acid metabolism (HP:0010894)3.02701448
44Abnormal urine output (HP:0012590)3.01218244
45Hyperactive renin-angiotensin system (HP:0000841)3.00818406
46Synostosis involving the elbow (HP:0003938)2.95725747
47Humeroradial synostosis (HP:0003041)2.95725747
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.94054908
49Absent phalangeal crease (HP:0006109)2.93166864
50Muscle stiffness (HP:0003552)2.89946538
51Sudden death (HP:0001699)2.88939584
52Abnormality of renal excretion (HP:0011036)2.88808986
53Myoglobinuria (HP:0002913)2.87463765
54Calcaneovalgus deformity (HP:0001848)2.85438207
55Muscle fiber inclusion bodies (HP:0100299)2.85178453
56Exercise-induced muscle cramps (HP:0003710)2.84483387
57Adactyly (HP:0009776)2.84380999
58Abnormality of fatty-acid metabolism (HP:0004359)2.82010004
59Symphalangism affecting the phalanges of the hand (HP:0009773)2.81882867
60Hypomagnesemia (HP:0002917)2.76729919
61Emphysema (HP:0002097)2.72445607
62Polydipsia (HP:0001959)2.66915445
63Abnormal drinking behavior (HP:0030082)2.66915445
64Xanthomatosis (HP:0000991)2.63758586
65Hyperammonemia (HP:0001987)2.62529597
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.61786742
67Deformed tarsal bones (HP:0008119)2.57970529
68Vascular calcification (HP:0004934)2.57662664
69Abnormality of the calf musculature (HP:0001430)2.57052374
70Radial bowing (HP:0002986)2.56888195
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.54901500
72Areflexia of lower limbs (HP:0002522)2.50289776
73Dicarboxylic aciduria (HP:0003215)2.49641363
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49641363
75Abnormality of skeletal muscle fiber size (HP:0012084)2.48184564
76Increased connective tissue (HP:0009025)2.48021283
77Intrahepatic cholestasis (HP:0001406)2.47110728
78Inflammation of the large intestine (HP:0002037)2.47078176
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46389233
80Oligodactyly (HP:0012165)2.46150203
81Mitral stenosis (HP:0001718)2.45307441
82Dehydration (HP:0001944)2.44661307
83Hypoglycemic coma (HP:0001325)2.44483275
84Hypoplastic nipples (HP:0002557)2.43393003
85Alkalosis (HP:0001948)2.41385421
86Abnormality of proline metabolism (HP:0010907)2.37979049
87Hydroxyprolinuria (HP:0003080)2.37979049
88Myocardial infarction (HP:0001658)2.35551105
89Facial diplegia (HP:0001349)2.35321848
90Asymmetric septal hypertrophy (HP:0001670)2.35096829
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34599822
92Congenital stationary night blindness (HP:0007642)2.33741753
93Abnormality of nucleobase metabolism (HP:0010932)2.33627141
94Type 1 muscle fiber predominance (HP:0003803)2.32209739
95Nemaline bodies (HP:0003798)2.31482595
96Cardiovascular calcification (HP:0011915)2.31196779
97Abnormality of the pubic bones (HP:0003172)2.30699798
98Frequent falls (HP:0002359)2.30132461
99Tetany (HP:0001281)2.29592471
100Hyperglycinemia (HP:0002154)2.27512795
101Ulnar deviation of finger (HP:0009465)2.26646129
102Recurrent sinusitis (HP:0011108)2.26532705
103Fetal akinesia sequence (HP:0001989)2.24702970
104Abnormality of urine glucose concentration (HP:0011016)2.23487938
105Glycosuria (HP:0003076)2.23487938
106Bundle branch block (HP:0011710)2.20376945
107Myopathic facies (HP:0002058)2.19528201
108Recurrent bronchitis (HP:0002837)2.19071348
109Hypoplastic iliac wings (HP:0002866)2.18300450
110Gastrointestinal inflammation (HP:0004386)2.16806429
111Chronic diarrhea (HP:0002028)2.15860025
112Widely patent fontanelles and sutures (HP:0004492)2.15491045
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.13848433
114Renal tubular acidosis (HP:0001947)2.12556287
115EMG: neuropathic changes (HP:0003445)2.10821831
116Abnormality of renin-angiotensin system (HP:0000847)2.10334301
117Abnormal delayed hypersensitivity skin test (HP:0002963)2.10255230
118Hypokalemia (HP:0002900)2.09964938
119Hyperkalemia (HP:0002153)2.09673717
120Rickets (HP:0002748)2.07906471
121Malignant hyperthermia (HP:0002047)2.06881400
122Metabolic acidosis (HP:0001942)2.06208950
123EMG: myopathic abnormalities (HP:0003458)2.06004077
124Tarsal synostosis (HP:0008368)2.05550305
125Abnormality of the neuromuscular junction (HP:0003398)2.05141428
126Fatigable weakness (HP:0003473)2.05141428
127Generalized muscle weakness (HP:0003324)2.04459143
128Delayed gross motor development (HP:0002194)2.02726542
129Exercise intolerance (HP:0003546)2.02067386
130Abnormality of potassium homeostasis (HP:0011042)2.01789806
131Acute necrotizing encephalopathy (HP:0006965)2.01150061
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.98770242
133Lymphopenia (HP:0001888)1.98022986
134IgM deficiency (HP:0002850)1.97651853
135Difficulty running (HP:0009046)1.96481029
136Abnormality of magnesium homeostasis (HP:0004921)1.96115493
137Rhabdomyolysis (HP:0003201)1.93726064
138Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.92056661
139Mitochondrial inheritance (HP:0001427)1.91779390
140IgA deficiency (HP:0002720)1.91409491
141Chronic mucocutaneous candidiasis (HP:0002728)1.90673995
142Recurrent cutaneous fungal infections (HP:0011370)1.90673995
143Abnormal mitochondria in muscle tissue (HP:0008316)1.90497724
144Abnormality of the fingertips (HP:0001211)1.89413873
145Broad ribs (HP:0000885)1.88961952
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88743120
147Barrel-shaped chest (HP:0001552)1.87096002
148Increased variability in muscle fiber diameter (HP:0003557)1.86984130
149Increased intramyocellular lipid droplets (HP:0012240)1.86428337
150Restrictive lung disease (HP:0002091)1.86352250
151Synostosis involving bones of the lower limbs (HP:0009138)1.85459575
152Synostosis involving bones of the feet (HP:0009140)1.85459575
153Dilated cardiomyopathy (HP:0001644)1.85411956
154Verrucae (HP:0200043)1.81213489
155Progressive macrocephaly (HP:0004481)1.80762262
156Weak cry (HP:0001612)1.79823977
157Aplasia/Hypoplasia of the fibula (HP:0006492)1.79057191
158Congenital hip dislocation (HP:0001374)1.78959900
159Bulbar palsy (HP:0001283)1.74877912
160Muscular dystrophy (HP:0003560)1.72920660
161Large for gestational age (HP:0001520)1.72544579
162Increased muscle lipid content (HP:0009058)1.71014151
163Acute encephalopathy (HP:0006846)1.69965363
164Type II lissencephaly (HP:0007260)1.68395145
165Molar tooth sign on MRI (HP:0002419)1.67887048
166Abnormality of midbrain morphology (HP:0002418)1.67887048
167Increased CSF lactate (HP:0002490)1.67190084
168Hip contracture (HP:0003273)1.66607279
169Limb-girdle muscle atrophy (HP:0003797)1.66158594
170Pancreatic fibrosis (HP:0100732)1.64558229
171Heart block (HP:0012722)1.61495812
172Hepatocellular necrosis (HP:0001404)1.61126080
173Gowers sign (HP:0003391)1.60013913
174Ventricular fibrillation (HP:0001663)1.58596854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.85020620
2PINK13.49361431
3MAP3K143.09699131
4OBSCN3.08438291
5WNK43.06281310
6MAP4K13.02063129
7TTN2.89733751
8BCKDK2.47267214
9ERN12.36428059
10BMPR1B2.32655315
11WNK32.25492943
12IRAK32.22041411
13TYK22.11614544
14FGFR42.10253085
15JAK11.91828802
16PIK3CG1.90247751
17INSRR1.87563545
18MAP4K21.77581855
19MAP3K31.72639393
20SIK11.69742163
21MAP3K131.69518951
22MUSK1.63435023
23EPHB11.57732371
24PDK31.57035660
25PDK41.57035660
26STK241.54959844
27MAP3K71.51412123
28NME11.50297322
29OXSR11.49682432
30STK38L1.47059095
31LRRK21.44560789
32EPHA31.41837217
33PHKG21.36394239
34PHKG11.36394239
35BTK1.35574691
36MST1R1.35007269
37CSF1R1.33285547
38MARK11.31271284
39CHUK1.30709336
40MAP2K41.29083947
41IKBKB1.27994683
42WNK11.27379941
43BLK1.26204606
44ERBB31.25013347
45PTK61.23735915
46TGFBR11.22590209
47ADRBK21.22276255
48GRK11.17471610
49PRKAA21.14417912
50MAPK131.11537874
51MST41.09675593
52DYRK1B1.09508252
53TBK11.07684808
54TGFBR21.04553044
55STK101.03821090
56GRK61.01387777
57MAP2K30.99406568
58LATS10.98195393
59PKN10.96731536
60TLK10.94357951
61DAPK20.93412759
62SYK0.91732215
63MAPK150.90292571
64IKBKE0.90055517
65TRIB30.90015272
66PDK20.89827947
67FRK0.88678426
68IRAK40.87063414
69CDK120.87020918
70MAPKAPK30.83746617
71MAPK120.82561747
72CDC42BPA0.81342953
73DMPK0.80579171
74JAK30.79721748
75TRPM70.78583114
76CDK80.77735571
77PIK3CA0.77492956
78CAMK2G0.76729062
79PRKCQ0.76539391
80PTK2B0.76329538
81STK390.76106705
82MAPK110.75974341
83PRKD10.73046660
84FGFR30.72446910
85PRKAA10.72340885
86CSK0.71205050
87PRKD20.70278997
88TIE10.67127284
89TNK20.66848133
90CAMK2D0.66635137
91CAMK2A0.64765143
92CAMK2B0.64648993
93DYRK20.64571014
94MAP3K40.62148776
95SIK30.62073257
96MARK30.61702421
97SGK30.60704810
98FER0.60619191
99MAP2K10.60523870
100CAMK10.60478614
101CCNB10.60278297
102NEK10.59538773
103HCK0.59278560
104ITK0.57594817
105MAP3K100.56429489
106ADRBK10.55994420
107NUAK10.55764042
108MYLK0.55360629
109KIT0.54121412
110JAK20.51305623
111ABL10.51073370
112ZAK0.50400953
113SGK20.49523188
114ROCK10.48371457
115CAMK40.47867331
116MAP2K70.47752029
117MAPK70.46650263
118PRKACA0.46108484
119PRKG10.45750129
120PIM10.45389699
121NEK90.44437128
122SGK4940.43441586
123SGK2230.43441586
124IRAK10.43393432
125LYN0.43196128
126SIK20.42977817
127RIPK40.42971523
128GRK70.42572006
129STK30.42471768
130AKT20.41795477
131FLT30.40421448
132SGK10.38690353
133MAP2K60.38294028
134PAK30.37636820
135NLK0.36513886
136ACVR1B0.36217501
137LIMK10.34955280
138CSNK1G20.33833981
139RPS6KB10.32225227
140PRKCG0.31792674
141MOS0.29071346
142CASK0.28740125
143TAOK30.28625805
144STK110.25924985
145PNCK0.24270025
146RPS6KA30.24028386
147PRKCI0.23554798
148MAPKAPK50.22988070
149MET0.22790811
150CSNK1A10.22211394
151MAPK40.21977053
152PRKCZ0.21241568
153RPS6KA60.19685435
154PRKCE0.18363005
155CAMKK20.17158503
156CDK90.17125714
157PRKACB0.16380417
158MAP2K20.15839448
159RPS6KA10.15725316
160RPS6KB20.14565334
161PRKCA0.13579886

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.86307921
2Parkinsons disease_Homo sapiens_hsa050123.09383237
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.01859613
4Fatty acid degradation_Homo sapiens_hsa000712.98005479
5Propanoate metabolism_Homo sapiens_hsa006402.91995551
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86035677
7Oxidative phosphorylation_Homo sapiens_hsa001902.74874771
8Tryptophan metabolism_Homo sapiens_hsa003802.69992345
9Circadian rhythm_Homo sapiens_hsa047102.41635346
10Butanoate metabolism_Homo sapiens_hsa006502.36497964
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.34333574
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31845507
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29520647
14Alzheimers disease_Homo sapiens_hsa050102.28540231
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.26763483
16Phototransduction_Homo sapiens_hsa047442.22300539
17Peroxisome_Homo sapiens_hsa041462.06957365
18Fatty acid metabolism_Homo sapiens_hsa012122.03068837
19beta-Alanine metabolism_Homo sapiens_hsa004101.99842308
20Calcium signaling pathway_Homo sapiens_hsa040201.99769438
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97541719
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86416323
23Phenylalanine metabolism_Homo sapiens_hsa003601.76230548
24Pyruvate metabolism_Homo sapiens_hsa006201.75461333
25B cell receptor signaling pathway_Homo sapiens_hsa046621.74898691
26Lysine degradation_Homo sapiens_hsa003101.73303839
27Primary immunodeficiency_Homo sapiens_hsa053401.73045115
28PPAR signaling pathway_Homo sapiens_hsa033201.72860923
29Histidine metabolism_Homo sapiens_hsa003401.71604220
30Arginine biosynthesis_Homo sapiens_hsa002201.67910904
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67174795
32Huntingtons disease_Homo sapiens_hsa050161.60536190
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60038651
34Vitamin digestion and absorption_Homo sapiens_hsa049771.59001380
35Starch and sucrose metabolism_Homo sapiens_hsa005001.56414147
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56199085
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53561141
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43272192
39Oxytocin signaling pathway_Homo sapiens_hsa049211.42791648
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42068452
41Insulin secretion_Homo sapiens_hsa049111.39371190
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37700529
43Retinol metabolism_Homo sapiens_hsa008301.33758494
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33042690
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30162843
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29922175
47Amphetamine addiction_Homo sapiens_hsa050311.29089459
48Hedgehog signaling pathway_Homo sapiens_hsa043401.26504057
49ABC transporters_Homo sapiens_hsa020101.25483686
50Complement and coagulation cascades_Homo sapiens_hsa046101.23527591
51Carbon metabolism_Homo sapiens_hsa012001.19267408
52Basal cell carcinoma_Homo sapiens_hsa052171.18071988
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17186208
54Cocaine addiction_Homo sapiens_hsa050301.16483470
55Chemical carcinogenesis_Homo sapiens_hsa052041.15839018
56Sulfur metabolism_Homo sapiens_hsa009201.14268607
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13371277
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.11868594
59Renin secretion_Homo sapiens_hsa049241.11731691
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08237511
61Pentose phosphate pathway_Homo sapiens_hsa000301.06616684
62Arginine and proline metabolism_Homo sapiens_hsa003301.06253862
63Tyrosine metabolism_Homo sapiens_hsa003501.05332721
64Morphine addiction_Homo sapiens_hsa050321.05069003
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.04207135
66Selenocompound metabolism_Homo sapiens_hsa004501.02039595
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.01418359
68Bile secretion_Homo sapiens_hsa049761.00202098
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99472582
70Dopaminergic synapse_Homo sapiens_hsa047280.99202573
71Hematopoietic cell lineage_Homo sapiens_hsa046400.97878864
72Circadian entrainment_Homo sapiens_hsa047130.96148730
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.95723988
74Ether lipid metabolism_Homo sapiens_hsa005650.95004201
75Fatty acid elongation_Homo sapiens_hsa000620.94998577
76Olfactory transduction_Homo sapiens_hsa047400.89805056
77Insulin resistance_Homo sapiens_hsa049310.89473399
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88864557
79Nicotine addiction_Homo sapiens_hsa050330.88246274
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83002494
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81445875
82Axon guidance_Homo sapiens_hsa043600.81260916
83Gastric acid secretion_Homo sapiens_hsa049710.81079209
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.80180326
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80048899
86Salivary secretion_Homo sapiens_hsa049700.75184013
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.73783290
88Ovarian steroidogenesis_Homo sapiens_hsa049130.72220776
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71583740
90cAMP signaling pathway_Homo sapiens_hsa040240.71180481
91Nitrogen metabolism_Homo sapiens_hsa009100.69831407
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68215983
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67868148
94Other glycan degradation_Homo sapiens_hsa005110.66018307
95Glycerolipid metabolism_Homo sapiens_hsa005610.65473225
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64574827
97Purine metabolism_Homo sapiens_hsa002300.64469658
98Protein export_Homo sapiens_hsa030600.63657002
99Dilated cardiomyopathy_Homo sapiens_hsa054140.63438151
100Staphylococcus aureus infection_Homo sapiens_hsa051500.60476065
101Regulation of autophagy_Homo sapiens_hsa041400.60195472
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59870475
103RNA polymerase_Homo sapiens_hsa030200.58765322
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55921607
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54289945
106Melanogenesis_Homo sapiens_hsa049160.52925151
107Protein digestion and absorption_Homo sapiens_hsa049740.52193116
108Basal transcription factors_Homo sapiens_hsa030220.50941035
109Glutamatergic synapse_Homo sapiens_hsa047240.50377594
110Glutathione metabolism_Homo sapiens_hsa004800.48230265
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.47779107
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.45982060
113Toxoplasmosis_Homo sapiens_hsa051450.45055134
114Sulfur relay system_Homo sapiens_hsa041220.44855176
115Taste transduction_Homo sapiens_hsa047420.44457616
116Fat digestion and absorption_Homo sapiens_hsa049750.44354724
117Biosynthesis of amino acids_Homo sapiens_hsa012300.43116424
118Viral myocarditis_Homo sapiens_hsa054160.42803555
119Long-term depression_Homo sapiens_hsa047300.42746640
120GABAergic synapse_Homo sapiens_hsa047270.42725649
121Linoleic acid metabolism_Homo sapiens_hsa005910.42624490
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42482011
123Serotonergic synapse_Homo sapiens_hsa047260.40104181
124Glucagon signaling pathway_Homo sapiens_hsa049220.38987335
125Osteoclast differentiation_Homo sapiens_hsa043800.38643178
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37487378
127RNA degradation_Homo sapiens_hsa030180.37086466
128Tight junction_Homo sapiens_hsa045300.36931820
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.35744413
130Arachidonic acid metabolism_Homo sapiens_hsa005900.35198793
131Cardiac muscle contraction_Homo sapiens_hsa042600.34323517
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33367628
133Ribosome_Homo sapiens_hsa030100.33283232
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32768552
135Caffeine metabolism_Homo sapiens_hsa002320.31663422
136Fructose and mannose metabolism_Homo sapiens_hsa000510.30810930
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29510645
138Antigen processing and presentation_Homo sapiens_hsa046120.28057159
139Metabolic pathways_Homo sapiens_hsa011000.28041365
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.27561212
141Leishmaniasis_Homo sapiens_hsa051400.27543945
142Folate biosynthesis_Homo sapiens_hsa007900.26872218
143Small cell lung cancer_Homo sapiens_hsa052220.26337393
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25048627
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24626461
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.21512574
147Hepatitis C_Homo sapiens_hsa051600.21102153
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19835166
149AMPK signaling pathway_Homo sapiens_hsa041520.19462238
150Mineral absorption_Homo sapiens_hsa049780.18126355
151Sphingolipid metabolism_Homo sapiens_hsa006000.15896942
152Fatty acid biosynthesis_Homo sapiens_hsa000610.15645636
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15289096
154Tuberculosis_Homo sapiens_hsa051520.15123282
155Insulin signaling pathway_Homo sapiens_hsa049100.15076213

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