TRIM66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)6.96435721
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.52446213
3adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.17080841
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.16938471
5neuron cell-cell adhesion (GO:0007158)5.08080027
6positive regulation of gamma-delta T cell activation (GO:0046645)4.88888104
7glutamate secretion (GO:0014047)4.83528267
8synaptic vesicle maturation (GO:0016188)4.73757715
9regulation of synaptic vesicle exocytosis (GO:2000300)4.66246756
10sensory perception of chemical stimulus (GO:0007606)4.64932866
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.61840599
12negative regulation of T cell mediated immunity (GO:0002710)4.58732098
13synaptic vesicle exocytosis (GO:0016079)4.57696472
14vocalization behavior (GO:0071625)4.54891805
15regulation of gamma-delta T cell differentiation (GO:0045586)4.43023174
16phosphorelay signal transduction system (GO:0000160)4.39591646
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36550897
18regulation of gamma-delta T cell activation (GO:0046643)4.33971686
19negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.33903223
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.30154968
21interferon-gamma production (GO:0032609)4.23407809
22regulation of synapse structural plasticity (GO:0051823)4.21023122
23neurotransmitter secretion (GO:0007269)4.19074562
24histone H3-K36 demethylation (GO:0070544)4.13088074
25regulation of chromatin binding (GO:0035561)4.11035018
26locomotory exploration behavior (GO:0035641)4.10033115
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04237680
28regulation of synaptic vesicle transport (GO:1902803)3.99740222
29protein localization to cilium (GO:0061512)3.98555485
30mating behavior (GO:0007617)3.98344444
31G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.93379264
32behavioral response to cocaine (GO:0048148)3.85608651
33regulation of glutamate receptor signaling pathway (GO:1900449)3.80543525
34protein localization to synapse (GO:0035418)3.74402978
35regulation of neuronal synaptic plasticity (GO:0048168)3.73127774
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65843171
37histone H3-K4 trimethylation (GO:0080182)3.65612630
38axonal fasciculation (GO:0007413)3.64842670
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.63597986
40layer formation in cerebral cortex (GO:0021819)3.61752810
41gamma-aminobutyric acid transport (GO:0015812)3.61346679
42membrane depolarization during action potential (GO:0086010)3.57667961
43neuron recognition (GO:0008038)3.56579237
44cerebellar Purkinje cell differentiation (GO:0021702)3.54344913
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52644124
46calcium ion-dependent exocytosis (GO:0017156)3.52441906
47negative regulation of microtubule polymerization (GO:0031115)3.49720228
48protein insertion into membrane (GO:0051205)3.48542185
49cellular response to ethanol (GO:0071361)3.46795608
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45028291
51synaptic vesicle endocytosis (GO:0048488)3.44251138
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42078766
53negative regulation of cell killing (GO:0031342)3.42078766
54detection of calcium ion (GO:0005513)3.40526730
55positive regulation of granulocyte differentiation (GO:0030854)3.39761484
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38397944
57neurotransmitter transport (GO:0006836)3.34545473
58regulation of B cell receptor signaling pathway (GO:0050855)3.33185681
59synaptic transmission, glutamatergic (GO:0035249)3.31423189
60regulation of histone H3-K27 methylation (GO:0061085)3.30772761
61protein polyglutamylation (GO:0018095)3.29202336
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28708600
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28332571
64activation of protein kinase A activity (GO:0034199)3.28295488
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.27325202
66negative regulation of erythrocyte differentiation (GO:0045647)3.26916689
67proline transport (GO:0015824)3.26666983
68snRNA transcription (GO:0009301)3.25969247
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.21373766
70cilium or flagellum-dependent cell motility (GO:0001539)3.21108734
71negative regulation of dendrite morphogenesis (GO:0050774)3.20927157
72positive regulation of CREB transcription factor activity (GO:0032793)3.20467177
73dopamine receptor signaling pathway (GO:0007212)3.20400143
74regulation of protein kinase A signaling (GO:0010738)3.19768796
75response to auditory stimulus (GO:0010996)3.18726647
76glutamate receptor signaling pathway (GO:0007215)3.18460698
77neuron-neuron synaptic transmission (GO:0007270)3.17647799
78cellular potassium ion homeostasis (GO:0030007)3.16688867
79B cell receptor signaling pathway (GO:0050853)3.16497326
80long-term memory (GO:0007616)3.14563630
81exploration behavior (GO:0035640)3.13623364
82positive regulation of synapse maturation (GO:0090129)3.13263593
83vesicle transport along microtubule (GO:0047496)3.12973519
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12240508
85regulation of neurotransmitter secretion (GO:0046928)3.10852287
86neurotransmitter-gated ion channel clustering (GO:0072578)3.09144920
87positive regulation of neurotransmitter transport (GO:0051590)3.08204860
88response to interleukin-15 (GO:0070672)3.06741200
89dendrite morphogenesis (GO:0048813)3.06587591
90mannose metabolic process (GO:0006013)3.05778102
91regulation of female receptivity (GO:0045924)3.05294624
92regulation of cilium movement (GO:0003352)3.04898438
93positive regulation of neurotransmitter secretion (GO:0001956)3.04134097
94histone H3-K9 demethylation (GO:0033169)3.03743565
95regulation of neurotransmitter levels (GO:0001505)3.03419826
96regulation of synaptic plasticity (GO:0048167)3.02640073
97positive regulation of histone deacetylation (GO:0031065)3.02415148
98neuronal action potential propagation (GO:0019227)3.00515074
99neuronal action potential (GO:0019228)2.99589233
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98025104
101neuromuscular process controlling posture (GO:0050884)2.97961269
102brain morphogenesis (GO:0048854)2.97819085
103prepulse inhibition (GO:0060134)2.97520577
104drug catabolic process (GO:0042737)2.97167012
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97054819
106exogenous drug catabolic process (GO:0042738)2.97032924
107auditory behavior (GO:0031223)2.95504489
108establishment of protein localization to Golgi (GO:0072600)2.95202097
109cellular response to glucagon stimulus (GO:0071377)2.94913512
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94686887
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94106010
112activated T cell proliferation (GO:0050798)2.93644630
113cellular response to prostaglandin stimulus (GO:0071379)2.93255661
114positive regulation of membrane potential (GO:0045838)2.93022936
115regulation of heart rate by cardiac conduction (GO:0086091)2.92015168
116membrane hyperpolarization (GO:0060081)2.90121421
117regulation of postsynaptic membrane potential (GO:0060078)2.90004129
118female mating behavior (GO:0060180)2.87972736
119negative thymic T cell selection (GO:0045060)2.87921081
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87674194
121synapse assembly (GO:0007416)2.86747902
122regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86479339
123positive regulation of T cell cytokine production (GO:0002726)2.86274432
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85539931
125negative regulation of adaptive immune response (GO:0002820)2.84976171
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.84911927
127phosphatidylethanolamine biosynthetic process (GO:0006646)2.84425168
128positive regulation of type 2 immune response (GO:0002830)2.84316641
129regulation of ARF protein signal transduction (GO:0032012)2.84285174
130negative regulation of leukocyte mediated immunity (GO:0002704)2.84232381
131postsynaptic membrane organization (GO:0001941)2.83533429
132dendritic spine morphogenesis (GO:0060997)2.83287001
133intraciliary transport (GO:0042073)2.82916568
134antigen processing and presentation of endogenous antigen (GO:0019883)2.82831061
135regulation of neurotransmitter transport (GO:0051588)2.81566352
136negative T cell selection (GO:0043383)2.80775876
137organelle transport along microtubule (GO:0072384)2.80647119
138regulation of T cell mediated cytotoxicity (GO:0001914)2.80263358
139transmission of nerve impulse (GO:0019226)2.80151156
140membrane depolarization (GO:0051899)2.79301246
141long-term synaptic potentiation (GO:0060291)2.78932434
142cardiac conduction (GO:0061337)2.78888116
143positive regulation of Rap GTPase activity (GO:0032854)2.77821988
144cellular extravasation (GO:0045123)2.77166165
145synaptic transmission (GO:0007268)2.75892782
146cell migration in hindbrain (GO:0021535)2.74754610
147positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74492597
148positive thymic T cell selection (GO:0045059)2.70356490
149phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69076875
150regulation of granulocyte differentiation (GO:0030852)2.66224172
151protein targeting to Golgi (GO:0000042)2.66104123
152negative regulation of alpha-beta T cell activation (GO:0046636)2.65321383
153regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63567616
154regulation of alpha-beta T cell proliferation (GO:0046640)2.63061435
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58475606
156histone lysine demethylation (GO:0070076)2.57734237
157JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56675664
158positive T cell selection (GO:0043368)2.55955377
159phosphatidylethanolamine metabolic process (GO:0046337)2.55519050
160histone H3-K4 methylation (GO:0051568)2.55485769
161interkinetic nuclear migration (GO:0022027)2.53308830
162negative regulation of cytokine production involved in immune response (GO:0002719)2.52051315
163positive regulation of protein deacetylation (GO:0090312)2.51570642
164negative regulation of B cell mediated immunity (GO:0002713)2.51378973
165negative regulation of immunoglobulin mediated immune response (GO:0002890)2.51378973
166T cell selection (GO:0045058)2.47332365
167growth hormone receptor signaling pathway (GO:0060396)2.47315209
168regulation of T cell cytokine production (GO:0002724)2.46828194
169monoubiquitinated protein deubiquitination (GO:0035520)2.45714435
170regulation of ARF GTPase activity (GO:0032312)2.45574912
171positive regulation of Rab GTPase activity (GO:0032851)2.45553085
172regulation of Rab GTPase activity (GO:0032313)2.45553085
173thymic T cell selection (GO:0045061)2.45432658
174positive regulation of T-helper 1 type immune response (GO:0002827)2.43803256
175positive regulation of alpha-beta T cell proliferation (GO:0046641)2.42631848
176cellular response to interleukin-15 (GO:0071350)2.41820729
177histone H3-K9 modification (GO:0061647)2.41526085
178histone demethylation (GO:0016577)2.41509859
179positive regulation of B cell differentiation (GO:0045579)2.40055978
180epoxygenase P450 pathway (GO:0019373)2.39874017
181positive regulation by symbiont of host defense response (GO:0052509)2.39257372
182modulation by symbiont of host defense response (GO:0052031)2.39257372
183modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39257372
184modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39257372
185positive regulation by organism of defense response of other organism involved in symbiotic interact2.39257372
186modulation by symbiont of host immune response (GO:0052553)2.39257372
187germinal center formation (GO:0002467)2.38740561
188regulation of protein activation cascade (GO:2000257)2.38095717
189regulation of complement activation (GO:0030449)2.37890002
190leukocyte aggregation (GO:0070486)2.36241052
191lymphocyte chemotaxis (GO:0048247)2.36076218
192histone lysine methylation (GO:0034968)2.35970330
193regulation of B cell mediated immunity (GO:0002712)2.35509269
194detection of bacterium (GO:0016045)2.35335380
195complement activation, alternative pathway (GO:0006957)2.34557951
196positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.33449577
197negative regulation of Rho protein signal transduction (GO:0035024)2.32154969
198regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.31196715
199regulation of immunoglobulin mediated immune response (GO:0002889)2.30796333
200detection of other organism (GO:0098543)2.30674349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.40967344
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.18301632
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38648336
4GBX2_23144817_ChIP-Seq_PC3_Human3.37934567
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10525927
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.66845879
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65583920
8DROSHA_22980978_ChIP-Seq_HELA_Human2.64808313
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55509724
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48535811
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46908365
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46908365
13REST_21632747_ChIP-Seq_MESCs_Mouse2.46637863
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42367559
15TAF15_26573619_Chip-Seq_HEK293_Human2.30612662
16RUNX_20019798_ChIP-Seq_JUKART_Human2.25918481
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18962506
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16373105
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15961491
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14622237
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.10816656
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05066224
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.04176147
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01840742
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.01429160
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00049222
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97819019
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97636688
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.93782400
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90181237
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87781383
32* REST_18959480_ChIP-ChIP_MESCs_Mouse1.87476887
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.87332459
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75097618
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70245887
36SMAD4_21799915_ChIP-Seq_A2780_Human1.67886777
37SPI1_23127762_ChIP-Seq_K562_Human1.67409449
38AR_21572438_ChIP-Seq_LNCaP_Human1.66377354
39AHR_22903824_ChIP-Seq_MCF-7_Human1.65066429
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64186836
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63495549
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61778542
43MYC_22102868_ChIP-Seq_BL_Human1.59971499
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59561069
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58412000
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.52975421
47SCL_19346495_ChIP-Seq_HPC-7_Human1.51483644
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51160106
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50502760
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50239098
51TCF7_22412390_ChIP-Seq_EML_Mouse1.50134045
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.50050722
53RNF2_27304074_Chip-Seq_NSC_Mouse1.49678489
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49647946
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48789732
56GATA1_19941826_ChIP-Seq_K562_Human1.46125052
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45061892
58VDR_21846776_ChIP-Seq_THP-1_Human1.43389980
59* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43249107
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43131446
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42865233
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.42668787
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41952551
64MYB_26560356_Chip-Seq_TH2_Human1.41650484
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39521750
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38096668
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37361837
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.36664385
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34917860
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.34717433
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34637056
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.33893558
73P300_19829295_ChIP-Seq_ESCs_Human1.33262846
74MAF_26560356_Chip-Seq_TH1_Human1.31536272
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31386767
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.29522720
77ZNF274_21170338_ChIP-Seq_K562_Hela1.28535624
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27159840
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26923946
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.26777615
81* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26713546
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25000937
83GATA2_19941826_ChIP-Seq_K562_Human1.24328669
84STAT3_23295773_ChIP-Seq_U87_Human1.23193801
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22886639
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.22814812
87MYB_26560356_Chip-Seq_TH1_Human1.22665214
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21584190
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.21090415
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.20989495
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20871680
92KDM2B_26808549_Chip-Seq_DND41_Human1.20491980
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20331795
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20079071
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19636690
96MAF_26560356_Chip-Seq_TH2_Human1.19609845
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19462853
98AR_19668381_ChIP-Seq_PC3_Human1.19354624
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.19340536
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19161157
101VDR_24763502_ChIP-Seq_THP-1_Human1.19141258
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17745591
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.17608116
104GATA3_27048872_Chip-Seq_THYMUS_Human1.17393192
105VDR_24787735_ChIP-Seq_THP-1_Human1.17282275
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17163157
107RUNX2_22187159_ChIP-Seq_PCA_Human1.16183255
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15945273
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15841784
110SMC4_20622854_ChIP-Seq_HELA_Human1.14248393
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13535965
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13507904
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12427595
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12427595
115UTX_26944678_Chip-Seq_JUKART_Human1.12292957
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11699949
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11658028
118TCF4_23295773_ChIP-Seq_U87_Human1.11194727
119LXR_22292898_ChIP-Seq_THP-1_Human1.11160353
120P68_20966046_ChIP-Seq_HELA_Human1.09951235
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09808485
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.08014949
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.07779652
124IGF1R_20145208_ChIP-Seq_DFB_Human1.06368462
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05818431
126RUNX1_27514584_Chip-Seq_MCF-7_Human1.02654219
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02410844
128BCOR_27268052_Chip-Seq_Bcells_Human1.01463500
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.01049811
130RING1B_27294783_Chip-Seq_NPCs_Mouse1.00876074
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00530979
132AR_25329375_ChIP-Seq_VCAP_Human1.00141098
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98105075
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97807854
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97470784
136GATA3_26560356_Chip-Seq_TH2_Human0.97166791
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.96842308
138KDM2B_26808549_Chip-Seq_K562_Human0.96280777
139TP63_22573176_ChIP-Seq_HFKS_Human0.95965357
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.95874463
141RAC3_21632823_ChIP-Seq_H3396_Human0.94674116
142NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94537845
143OCT4_19829295_ChIP-Seq_ESCs_Human0.93733247
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93397346
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92766203
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92694281
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91949505
148SMRT_27268052_Chip-Seq_Bcells_Human0.91940585
149RXR_22158963_ChIP-Seq_LIVER_Mouse0.91715512
150* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91674681
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90815128
152WT1_19549856_ChIP-ChIP_CCG9911_Human0.90596601
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90462499
154CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89756676
155* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89493524
156RUNX1_22412390_ChIP-Seq_EML_Mouse0.89489017
157P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88874788
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88430021
159PHF8_20622854_ChIP-Seq_HELA_Human0.87793820
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87554149
161* OCT4_20526341_ChIP-Seq_ESCs_Human0.87498536
162* P300_27268052_Chip-Seq_Bcells_Human0.87357874
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86962017
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85860414
165EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85790021
166* SMAD4_21741376_ChIP-Seq_EPCs_Human0.85681399
167ER_23166858_ChIP-Seq_MCF-7_Human0.85576318
168HNF4A_19822575_ChIP-Seq_HepG2_Human0.85406447
169TP53_16413492_ChIP-PET_HCT116_Human0.85135768
170ERA_21632823_ChIP-Seq_H3396_Human0.85026367
171STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84181965
172MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84124476
173BCL6_27268052_Chip-Seq_Bcells_Human0.84121027
174* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83920528
175EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83806698
176ELF1_20517297_ChIP-Seq_JURKAT_Human0.83691530
177RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83580156
178JUN_21703547_ChIP-Seq_K562_Human0.83440278
179BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.83376794
180CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83087408
181SOX9_26525672_Chip-Seq_HEART_Mouse0.82580099
182RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82563472
183NANOG_18555785_Chip-Seq_ESCs_Mouse0.82215749
184* TP53_18474530_ChIP-ChIP_U2OS_Human0.81372665
185TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80319854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.72043220
2MP0004859_abnormal_synaptic_plasticity4.79891039
3MP0005499_abnormal_olfactory_system3.73218029
4MP0005394_taste/olfaction_phenotype3.73218029
5MP0005645_abnormal_hypothalamus_physiol3.58655665
6MP0004270_analgesia3.52663224
7MP0008789_abnormal_olfactory_epithelium3.47409507
8MP0003635_abnormal_synaptic_transmissio3.41260612
9MP0003880_abnormal_central_pattern3.31305451
10MP0003172_abnormal_lysosome_physiology2.85387765
11MP0003787_abnormal_imprinting2.80223383
12MP0002063_abnormal_learning/memory/cond2.73346944
13MP0009745_abnormal_behavioral_response2.69241507
14MP0003763_abnormal_thymus_physiology2.67328938
15MP0009046_muscle_twitch2.63929408
16MP0002734_abnormal_mechanical_nocicepti2.55211707
17MP0002064_seizures2.54948200
18MP0005310_abnormal_salivary_gland2.48418744
19MP0005360_urolithiasis2.46142357
20MP0003436_decreased_susceptibility_to2.41651830
21MP0002272_abnormal_nervous_system2.41046622
22MP0002138_abnormal_hepatobiliary_system2.40433505
23MP0001486_abnormal_startle_reflex2.39519986
24MP0005423_abnormal_somatic_nervous2.38303034
25MP0001800_abnormal_humoral_immune2.38113387
26MP0003195_calcinosis2.37855729
27MP0002184_abnormal_innervation2.32689182
28MP0002572_abnormal_emotion/affect_behav2.30167525
29MP0001835_abnormal_antigen_presentation2.28456466
30MP0005365_abnormal_bile_salt2.27263727
31MP0006276_abnormal_autonomic_nervous2.25343801
32MP0000685_abnormal_immune_system2.19026605
33MP0001968_abnormal_touch/_nociception2.15900682
34MP0005646_abnormal_pituitary_gland2.12566340
35MP0001790_abnormal_immune_system2.10665993
36MP0005387_immune_system_phenotype2.10665993
37MP0003045_fibrosis2.07917107
38MP0002396_abnormal_hematopoietic_system2.03551140
39MP0002557_abnormal_social/conspecific_i1.96770417
40MP0002822_catalepsy1.95364116
41MP0003646_muscle_fatigue1.94431797
42MP0004130_abnormal_muscle_cell1.92666575
43MP0005670_abnormal_white_adipose1.92372418
44MP0005085_abnormal_gallbladder_physiolo1.86504269
45MP0001873_stomach_inflammation1.83898629
46MP0010329_abnormal_lipoprotein_level1.83477841
47MP0000778_abnormal_nervous_system1.82912893
48MP0002067_abnormal_sensory_capabilities1.82693114
49MP0001501_abnormal_sleep_pattern1.79592484
50MP0002723_abnormal_immune_serum1.77140154
51MP0004858_abnormal_nervous_system1.75483170
52MP0001485_abnormal_pinna_reflex1.73427013
53MP0005451_abnormal_body_composition1.69737853
54MP0005671_abnormal_response_to1.65375696
55MP0005000_abnormal_immune_tolerance1.63206723
56MP0002139_abnormal_hepatobiliary_system1.61568040
57MP0002419_abnormal_innate_immunity1.60636368
58MP0002735_abnormal_chemical_nociception1.60512673
59MP0002420_abnormal_adaptive_immunity1.60505326
60MP0008057_abnormal_DNA_replication1.58340641
61MP0005025_abnormal_response_to1.58205761
62MP0001819_abnormal_immune_cell1.56650373
63MP0002736_abnormal_nociception_after1.56068999
64MP0004811_abnormal_neuron_physiology1.55030505
65MP0004381_abnormal_hair_follicle1.54989934
66MP0002452_abnormal_antigen_presenting1.54534340
67MP0002882_abnormal_neuron_morphology1.54087583
68MP0003183_abnormal_peptide_metabolism1.52921000
69MP0002132_abnormal_respiratory_system1.50612930
70MP0002398_abnormal_bone_marrow1.48114670
71MP0009115_abnormal_fat_cell1.46185938
72MP0001970_abnormal_pain_threshold1.44378873
73MP0001986_abnormal_taste_sensitivity1.44372141
74MP0002160_abnormal_reproductive_system1.43159024
75MP0002006_tumorigenesis1.42811239
76MP0008875_abnormal_xenobiotic_pharmacok1.39252876
77MP0003656_abnormal_erythrocyte_physiolo1.38715926
78MP0008569_lethality_at_weaning1.36684987
79MP0003252_abnormal_bile_duct1.35630615
80MP0000716_abnormal_immune_system1.33922721
81MP0003303_peritoneal_inflammation1.33068176
82MP0010234_abnormal_vibrissa_follicle1.31045545
83MP0004742_abnormal_vestibular_system1.30823811
84MP0001440_abnormal_grooming_behavior1.30381336
85MP0005551_abnormal_eye_electrophysiolog1.28080687
86MP0003300_gastrointestinal_ulcer1.28005763
87MP0008877_abnormal_DNA_methylation1.27798257
88MP0003866_abnormal_defecation1.26456746
89MP0004947_skin_inflammation1.26196717
90MP0004043_abnormal_pH_regulation1.26016557
91MP0003724_increased_susceptibility_to1.24635149
92MP0002733_abnormal_thermal_nociception1.24591070
93MP0002102_abnormal_ear_morphology1.23450894
94MP0005409_darkened_coat_color1.22220162
95MP0005386_behavior/neurological_phenoty1.21564361
96MP0004924_abnormal_behavior1.21564361
97MP0002166_altered_tumor_susceptibility1.21293314
98MP0002152_abnormal_brain_morphology1.21051226
99MP0000689_abnormal_spleen_morphology1.19844823
100MP0000955_abnormal_spinal_cord1.18756730
101MP0000703_abnormal_thymus_morphology1.18143339
102MP0005410_abnormal_fertilization1.18111965
103MP0002066_abnormal_motor_capabilities/c1.17650921
104MP0001666_abnormal_nutrient_absorption1.16410898
105MP0010155_abnormal_intestine_physiology1.15157050
106MP0001188_hyperpigmentation1.14965584
107MP0002168_other_aberrant_phenotype1.14582078
108MP0002118_abnormal_lipid_homeostasis1.14445871
109MP0005464_abnormal_platelet_physiology1.13610707
110MP0005397_hematopoietic_system_phenotyp1.13584716
111MP0001545_abnormal_hematopoietic_system1.13584716
112MP0002752_abnormal_somatic_nervous1.13104516
113MP0003879_abnormal_hair_cell1.13016773
114MP0003122_maternal_imprinting1.11707141
115MP0005187_abnormal_penis_morphology1.10963287
116MP0002909_abnormal_adrenal_gland1.10592294
117MP0000631_abnormal_neuroendocrine_gland1.09483346
118MP0002009_preneoplasia1.08741945
119MP0002722_abnormal_immune_system1.08286370
120MP0002971_abnormal_brown_adipose1.07084050
121MP0002229_neurodegeneration1.06665106
122MP0000609_abnormal_liver_physiology1.06633222
123MP0001502_abnormal_circadian_rhythm1.05634660
124MP0009780_abnormal_chondrocyte_physiolo1.04635408
125MP0002653_abnormal_ependyma_morphology1.02895981
126MP0000569_abnormal_digit_pigmentation1.02849357
127MP0002405_respiratory_system_inflammati1.02657618
128MP0003633_abnormal_nervous_system1.01758905
129MP0008961_abnormal_basal_metabolism0.99708569
130MP0002429_abnormal_blood_cell0.99209601
131MP0001661_extended_life_span0.99062661
132MP0003690_abnormal_glial_cell0.98186275
133MP0009278_abnormal_bone_marrow0.97673065
134MP0005171_absent_coat_pigmentation0.97033343
135MP0001963_abnormal_hearing_physiology0.96714968
136MP0001765_abnormal_ion_homeostasis0.95334888
137MP0002933_joint_inflammation0.95082525
138MP0008469_abnormal_protein_level0.94926190
139MP0001845_abnormal_inflammatory_respons0.94866367
140MP0002233_abnormal_nose_morphology0.94300154
141MP0005375_adipose_tissue_phenotype0.94169409
142MP0004145_abnormal_muscle_electrophysio0.94069687
143MP0000015_abnormal_ear_pigmentation0.92844516
144MP0002693_abnormal_pancreas_physiology0.91894574
145MP0005448_abnormal_energy_balance0.91790449
146MP0008874_decreased_physiological_sensi0.91298430
147MP0005666_abnormal_adipose_tissue0.89375956
148MP0002970_abnormal_white_adipose0.88063962
149MP0004885_abnormal_endolymph0.87974156
150MP0009785_altered_susceptibility_to0.87474321
151MP0001542_abnormal_bone_strength0.87360534
152MP0000372_irregular_coat_pigmentation0.86982158
153MP0001905_abnormal_dopamine_level0.85911900
154MP0003121_genomic_imprinting0.85545653
155MP0005377_hearing/vestibular/ear_phenot0.85030369
156MP0003878_abnormal_ear_physiology0.85030369
157MP0009333_abnormal_splenocyte_physiolog0.84718994
158MP0003631_nervous_system_phenotype0.83807924
159MP0002078_abnormal_glucose_homeostasis0.81899641
160MP0005334_abnormal_fat_pad0.81624094
161MP0003861_abnormal_nervous_system0.81617632
162MP0005623_abnormal_meninges_morphology0.81466565
163MP0004142_abnormal_muscle_tone0.81016503
164MP0004808_abnormal_hematopoietic_stem0.80892876
165MP0008872_abnormal_physiological_respon0.79630765
166MP0004085_abnormal_heartbeat0.79598523
167MP0002928_abnormal_bile_duct0.78494023
168MP0001348_abnormal_lacrimal_gland0.78258648
169MP0001851_eye_inflammation0.78032559
170MP0002136_abnormal_kidney_physiology0.76184285
171MP0000003_abnormal_adipose_tissue0.75057990
172MP0003634_abnormal_glial_cell0.74886111
173MP0002069_abnormal_eating/drinking_beha0.74668081
174MP0000751_myopathy0.74241500
175MP0000026_abnormal_inner_ear0.71458095
176MP0005389_reproductive_system_phenotype0.70668651
177MP0000013_abnormal_adipose_tissue0.70654196
178MP0004134_abnormal_chest_morphology0.69229786
179MP0003329_amyloid_beta_deposits0.68146375
180MP0002751_abnormal_autonomic_nervous0.67474152
181MP0003137_abnormal_impulse_conducting0.66370167
182MP0004484_altered_response_of0.65418342
183MP0002876_abnormal_thyroid_physiology0.64480737
184MP0001529_abnormal_vocalization0.63531691
185MP0003698_abnormal_male_reproductive0.61986267
186MP0001943_abnormal_respiration0.59244051
187MP0001177_atelectasis0.59201678
188MP0005535_abnormal_body_temperature0.55994765
189MP0010770_preweaning_lethality0.52444976

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)5.83051725
2Atonic seizures (HP:0010819)5.63517554
3Focal motor seizures (HP:0011153)5.50066247
4Focal seizures (HP:0007359)5.14149821
5Optic neuritis (HP:0100653)4.81856296
6Retrobulbar optic neuritis (HP:0100654)4.81856296
7Myositis (HP:0100614)4.39253448
8Orchitis (HP:0100796)4.32366340
9Myokymia (HP:0002411)4.30009002
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20241991
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.10871594
12Absence seizures (HP:0002121)4.08999995
13Pancreatic fibrosis (HP:0100732)3.86753149
14Generalized tonic-clonic seizures (HP:0002069)3.76006014
15Abnormal respiratory motile cilium physiology (HP:0012261)3.69725583
16Gait imbalance (HP:0002141)3.64857303
17Abnormality of the fingertips (HP:0001211)3.62827707
18Epileptic encephalopathy (HP:0200134)3.62603425
19Dialeptic seizures (HP:0011146)3.57733663
20Panhypogammaglobulinemia (HP:0003139)3.54539113
21Visual hallucinations (HP:0002367)3.49519163
22Hyperventilation (HP:0002883)3.46868664
23Congenital primary aphakia (HP:0007707)3.41679921
24Progressive cerebellar ataxia (HP:0002073)3.33995036
25Nephrogenic diabetes insipidus (HP:0009806)3.30998285
26Hypothermia (HP:0002045)3.23166520
27Keratoconjunctivitis sicca (HP:0001097)3.22610728
28Medial flaring of the eyebrow (HP:0010747)3.20630034
29Abnormal ciliary motility (HP:0012262)3.20312880
30Chronic mucocutaneous candidiasis (HP:0002728)3.12778340
31Recurrent cutaneous fungal infections (HP:0011370)3.12778340
32Colitis (HP:0002583)3.11952033
33Anosmia (HP:0000458)3.10450870
34Limb dystonia (HP:0002451)3.10259274
35Keratoconjunctivitis (HP:0001096)3.03466067
36Molar tooth sign on MRI (HP:0002419)3.02617154
37Abnormality of midbrain morphology (HP:0002418)3.02617154
38Hypoplastic ischia (HP:0003175)3.02096068
39Encephalitis (HP:0002383)2.98163838
40Rhinitis (HP:0012384)2.97075305
41Recurrent fungal infections (HP:0002841)2.96193818
42Eczematoid dermatitis (HP:0000976)2.93685650
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.88681317
44Abnormality of macular pigmentation (HP:0008002)2.88355377
45Action tremor (HP:0002345)2.85124844
46Genital tract atresia (HP:0001827)2.84138746
47Hyperlipoproteinemia (HP:0010980)2.83145951
48Abnormal respiratory motile cilium morphology (HP:0005938)2.82493625
49Abnormal respiratory epithelium morphology (HP:0012253)2.82493625
50Prolonged bleeding time (HP:0003010)2.82400456
51Deep venous thrombosis (HP:0002625)2.81853251
52Truncal ataxia (HP:0002078)2.79643518
53Meningitis (HP:0001287)2.79119687
54Broad-based gait (HP:0002136)2.77996586
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.74799959
56Absent/shortened dynein arms (HP:0200106)2.74799959
57Ankle clonus (HP:0011448)2.73123382
58Inflammation of the large intestine (HP:0002037)2.69698264
59Hemoptysis (HP:0002105)2.67329314
60Gaze-evoked nystagmus (HP:0000640)2.65070667
61Pulmonary embolism (HP:0002204)2.63180951
62Gastrointestinal inflammation (HP:0004386)2.61497766
63Poor coordination (HP:0002370)2.58069547
64Vaginal atresia (HP:0000148)2.54523522
65Vasculitis (HP:0002633)2.54093390
66Dyschromatopsia (HP:0007641)2.53922126
67Recurrent gram-negative bacterial infections (HP:0005420)2.52241698
68Aplasia/Hypoplasia of the lens (HP:0008063)2.51965087
69Gastrointestinal infarctions (HP:0005244)2.51017695
70Decreased central vision (HP:0007663)2.49348781
71Retinal dysplasia (HP:0007973)2.48328219
72Papilledema (HP:0001085)2.47075941
73Abnormality of the ischium (HP:0003174)2.44874226
74Spontaneous hematomas (HP:0007420)2.43415514
75Genetic anticipation (HP:0003743)2.40273170
76Elevated erythrocyte sedimentation rate (HP:0003565)2.38346174
77Hypochromic anemia (HP:0001931)2.37674145
78Postaxial hand polydactyly (HP:0001162)2.35859398
79Median cleft lip (HP:0000161)2.35380656
80Urinary bladder sphincter dysfunction (HP:0002839)2.34990583
81Supranuclear gaze palsy (HP:0000605)2.34343046
82Pulmonary infiltrates (HP:0002113)2.31715514
83Arterial thrombosis (HP:0004420)2.30550889
84Protruding tongue (HP:0010808)2.30491261
85Prominent nose (HP:0000448)2.29083573
86Generalized hypopigmentation of hair (HP:0011358)2.28759866
87Bradycardia (HP:0001662)2.27477455
88Agammaglobulinemia (HP:0004432)2.27020255
89Recurrent skin infections (HP:0001581)2.26500563
90Truncal obesity (HP:0001956)2.26464472
91Dysdiadochokinesis (HP:0002075)2.26384791
92Failure to thrive in infancy (HP:0001531)2.26098776
93Hemorrhage of the eye (HP:0011885)2.24897769
94Specific learning disability (HP:0001328)2.24205958
95Obstructive sleep apnea (HP:0002870)2.23697616
96Increased IgE level (HP:0003212)2.22702753
97Joint hemorrhage (HP:0005261)2.22540956
98Complement deficiency (HP:0004431)2.22190360
99Insomnia (HP:0100785)2.21618162
100Impaired vibration sensation in the lower limbs (HP:0002166)2.20516466
101Impaired smooth pursuit (HP:0007772)2.19776709
102Central scotoma (HP:0000603)2.18527759
103Nephronophthisis (HP:0000090)2.17977066
104Torticollis (HP:0000473)2.17713508
105Fair hair (HP:0002286)2.16807749
106Postaxial foot polydactyly (HP:0001830)2.14484627
107Abnormality of the lower motor neuron (HP:0002366)2.12038297
108Chronic hepatic failure (HP:0100626)2.10325090
109Depression (HP:0000716)2.10277259
110Abnormality of pain sensation (HP:0010832)2.09350576
111Impaired pain sensation (HP:0007328)2.09350576
112Severe visual impairment (HP:0001141)2.09038452
113Blue irides (HP:0000635)2.07251211
114True hermaphroditism (HP:0010459)2.06907148
115Pustule (HP:0200039)2.05361016
116Abnormality of dentin (HP:0010299)2.04625541
117Syncope (HP:0001279)2.03575155
118Abnormal EKG (HP:0003115)2.03520908
119Keratitis (HP:0000491)2.02793310
120Abnormality of T cell physiology (HP:0011840)2.02458425
121Poor eye contact (HP:0000817)2.01822990
122Heterotopia (HP:0002282)2.01803443
123Drooling (HP:0002307)2.01608843
124Excessive salivation (HP:0003781)2.01608843
125Gingival bleeding (HP:0000225)2.00820930
126Amblyopia (HP:0000646)2.00781156
127Gangrene (HP:0100758)2.00611933
128Epistaxis (HP:0000421)2.00593814
129Postural instability (HP:0002172)2.00465961
130Fetal akinesia sequence (HP:0001989)2.00432842
131Abnormality of the endocardium (HP:0004306)1.99298248
132Abnormality of the periventricular white matter (HP:0002518)1.98904105
133Acne (HP:0001061)1.96878900
134Recurrent bacterial skin infections (HP:0005406)1.95958709
135Recurrent viral infections (HP:0004429)1.95363320
136Inappropriate behavior (HP:0000719)1.94348285
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94077724
138Gingivitis (HP:0000230)1.93832019
139Hypoplasia of the thymus (HP:0000778)1.92755362
140Prolonged partial thromboplastin time (HP:0003645)1.91793405
141Anorexia (HP:0002039)1.91154671
142Dysmetria (HP:0001310)1.90225069
143Recurrent abscess formation (HP:0002722)1.90197112
144Slow saccadic eye movements (HP:0000514)1.89542964
145Palpitations (HP:0001962)1.89302964
146Absent speech (HP:0001344)1.89290862
147Hyperkalemia (HP:0002153)1.88480640
148Insidious onset (HP:0003587)1.87678625
149Termporal pattern (HP:0011008)1.87678625
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.86525945
151Abnormality of T cells (HP:0002843)1.86285831
152Intellectual disability, moderate (HP:0002342)1.86052963
153Chronic bronchitis (HP:0004469)1.85897039
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85225454
155Dysmetric saccades (HP:0000641)1.84632169
156Abnormality of salivation (HP:0100755)1.84621017
157Choroideremia (HP:0001139)1.83600168
158Recurrent sinusitis (HP:0011108)1.83278414
159Impaired social interactions (HP:0000735)1.82386522
160Abnormal social behavior (HP:0012433)1.82386522
161Abnormality of ocular smooth pursuit (HP:0000617)1.81754984
162Left ventricular hypertrophy (HP:0001712)1.81209605
163Abnormal eating behavior (HP:0100738)1.80817287
164Agitation (HP:0000713)1.80467223
165Abnormality of the corticospinal tract (HP:0002492)1.79946728
166Nasal polyposis (HP:0100582)1.79912785
167Neoplasm of the heart (HP:0100544)1.78906497
168Anxiety (HP:0000739)1.78873098
169Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78846007
170Prolonged QT interval (HP:0001657)1.77612346
171Recurrent bronchitis (HP:0002837)1.77382275
172Scanning speech (HP:0002168)1.76572069
173Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75980599
174Focal dystonia (HP:0004373)1.75287093
175Abnormality of lateral ventricle (HP:0030047)1.74921288
176Decreased circulating renin level (HP:0003351)1.74707085
177Abnormality of the pleura (HP:0002103)1.74471023
178Neonatal hypoglycemia (HP:0001998)1.73515503
179Clumsiness (HP:0002312)1.70773765
180Hypochromic microcytic anemia (HP:0004840)1.68965261
181Abnormality of complement system (HP:0005339)1.67832307
182Poikilocytosis (HP:0004447)1.66698166
183Chronic diarrhea (HP:0002028)1.66239174
184Widely spaced teeth (HP:0000687)1.65572546
185Stomatitis (HP:0010280)1.64924271
186Menorrhagia (HP:0000132)1.62170899
187Cheilitis (HP:0100825)1.61511942
188T lymphocytopenia (HP:0005403)1.58150571
189Abnormal drinking behavior (HP:0030082)1.57506445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.14758427
2NTRK33.13899866
3MAP2K73.12466459
4ERBB33.00806945
5MAP3K42.81839532
6CASK2.70243362
7DAPK22.66614748
8ARAF2.64839937
9FRK2.62822134
10CDK122.44463392
11MARK12.44317457
12TRIB32.42074493
13NTRK22.37355627
14MINK12.29118314
15ERN12.27282854
16MAPK132.23861388
17RIPK12.14771311
18BMPR22.13728555
19MAP4K12.12000044
20EPHA42.08784934
21NEK92.00428082
22PLK21.98086808
23TAOK31.94828789
24FGFR41.93540533
25EEF2K1.82209520
26FGFR31.80855378
27MAP2K41.79041712
28TYK21.75882470
29SIK21.74190368
30PRPF4B1.73382068
31BLK1.68260267
32AKT31.60514294
33MAP3K121.55584125
34BRD41.54392867
35MAP3K71.49351172
36BTK1.45772519
37SIK11.43643653
38DAPK11.41314917
39JAK11.41076308
40NLK1.40985643
41EPHA31.39826849
42EPHB11.39127307
43MAP2K31.38646588
44SGK21.33301466
45PAK61.33083277
46UHMK11.31967000
47SYK1.30156182
48TNK21.29460363
49BRAF1.28858579
50CAMKK11.26711100
51CDK51.25421685
52TXK1.24078098
53SGK2231.23461911
54SGK4941.23461911
55PHKG21.22038207
56PHKG11.22038207
57PRKCG1.21528945
58MAPK151.18064862
59TNIK1.16882820
60ZAP701.16451211
61ITK1.15176978
62JAK31.15151401
63CAMKK21.13695240
64MAPKAPK31.11323824
65FGFR21.08538761
66PLK41.08514223
67GRK51.08261028
68PKN21.07892097
69CAMK1D1.06376874
70STK381.05078321
71MAP3K131.04627498
72KSR21.04404947
73CDK191.03945640
74SGK31.02689006
75MAPK110.98919548
76PRKD30.98845979
77NTRK10.97661589
78CSNK1G20.96937334
79WNK40.96917335
80PRKAA20.96776202
81CAMK2B0.95596247
82MAP2K60.95032947
83TEC0.94006174
84HCK0.91989059
85BMPR1B0.91129132
86PAK30.90923430
87MAP3K140.90464581
88CSF1R0.89219247
89ACVR1B0.89090820
90SRPK10.88929913
91DYRK1A0.87987156
92JAK20.87390507
93SIK30.87384344
94MAPK120.86946364
95RET0.85435870
96PRKCH0.85175691
97KSR10.84936239
98LCK0.84270759
99TRPM70.82950420
100RPS6KA20.82279816
101CSK0.82238421
102CAMK2D0.81817316
103MAPKAPK50.80392757
104PIK3CG0.79501149
105GRK60.77166462
106CAMK1G0.75663220
107OXSR10.74369967
108KIT0.74301353
109MTOR0.74141309
110TYRO30.73967146
111MELK0.73895964
112CAMK2A0.72995360
113YES10.71403463
114CDK180.69211894
115CDK150.66501366
116IKBKE0.65249219
117IRAK40.65116173
118INSRR0.64914361
119PNCK0.64781840
120PIK3CA0.64327279
121MAPK70.62072366
122CSNK1A1L0.61701707
123CCNB10.61349947
124STK110.61266053
125PRKAA10.60676528
126CDK140.58573862
127CAMK2G0.58211425
128PDPK10.58199723
129LYN0.56812580
130CDK11A0.56224028
131CSNK1G30.55786571
132RIPK40.55735546
133PDK10.54444299
134PRKCQ0.53264362
135MARK30.51173600
136RPS6KB10.50358547
137PRKD20.49911204
138CAMK40.49885636
139CAMK10.49838434
140MAP2K20.49349165
141FES0.47919701
142PRKCE0.47662996
143PRKCZ0.46912026
144MARK20.46855745
145MAP3K60.46202010
146HIPK20.46200469
147FER0.45964035
148SGK10.43018645
149GRK10.41385035
150PTK2B0.40899741
151DDR20.40264368
152MAP3K20.40260212
153MAPK100.39156317
154FGR0.39013398
155ICK0.38510885
156PINK10.38351215
157PRKCB0.37433293
158RAF10.36928844
159WNK10.36572030
160MAPK80.36018911
161MAP3K10.34861620
162CDC42BPA0.34177761

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.73210847
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27521650
3Nicotine addiction_Homo sapiens_hsa050333.02226611
4GABAergic synapse_Homo sapiens_hsa047272.77982976
5Circadian entrainment_Homo sapiens_hsa047132.77347098
6Morphine addiction_Homo sapiens_hsa050322.71548919
7Phototransduction_Homo sapiens_hsa047442.65007762
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56687536
9Glutamatergic synapse_Homo sapiens_hsa047242.50098356
10Dopaminergic synapse_Homo sapiens_hsa047282.31047569
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.26452122
12ABC transporters_Homo sapiens_hsa020102.22955145
13Amphetamine addiction_Homo sapiens_hsa050312.16601191
14Long-term potentiation_Homo sapiens_hsa047202.14751256
15Taste transduction_Homo sapiens_hsa047422.07684993
16Insulin secretion_Homo sapiens_hsa049112.03198434
17Cholinergic synapse_Homo sapiens_hsa047251.96235887
18Serotonergic synapse_Homo sapiens_hsa047261.87177457
19Salivary secretion_Homo sapiens_hsa049701.81942971
20B cell receptor signaling pathway_Homo sapiens_hsa046621.74901407
21Collecting duct acid secretion_Homo sapiens_hsa049661.72252857
22Staphylococcus aureus infection_Homo sapiens_hsa051501.71561239
23Primary immunodeficiency_Homo sapiens_hsa053401.71248832
24Gastric acid secretion_Homo sapiens_hsa049711.64428670
25Complement and coagulation cascades_Homo sapiens_hsa046101.60958783
26Acute myeloid leukemia_Homo sapiens_hsa052211.58730259
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56108222
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55141790
29Linoleic acid metabolism_Homo sapiens_hsa005911.47687818
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46868201
31T cell receptor signaling pathway_Homo sapiens_hsa046601.45332459
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.42564977
33GnRH signaling pathway_Homo sapiens_hsa049121.40434768
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40404180
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36316957
36Renin secretion_Homo sapiens_hsa049241.36033545
37Lysine degradation_Homo sapiens_hsa003101.34597217
38Oxytocin signaling pathway_Homo sapiens_hsa049211.32698906
39Calcium signaling pathway_Homo sapiens_hsa040201.32571053
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.26745687
41Caffeine metabolism_Homo sapiens_hsa002321.25567959
42Insulin resistance_Homo sapiens_hsa049311.24564975
43cAMP signaling pathway_Homo sapiens_hsa040241.24494345
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21386530
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21101172
46Cocaine addiction_Homo sapiens_hsa050301.18500342
47Osteoclast differentiation_Homo sapiens_hsa043801.15422214
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15223671
49Long-term depression_Homo sapiens_hsa047301.11194456
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11183780
51Type II diabetes mellitus_Homo sapiens_hsa049301.10404505
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08496873
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06868704
54Estrogen signaling pathway_Homo sapiens_hsa049151.04734451
55Other glycan degradation_Homo sapiens_hsa005111.03958134
56Histidine metabolism_Homo sapiens_hsa003401.03623824
57Vibrio cholerae infection_Homo sapiens_hsa051101.02450533
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.02245149
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01031330
60Gap junction_Homo sapiens_hsa045401.00750122
61ErbB signaling pathway_Homo sapiens_hsa040120.99095565
62Glioma_Homo sapiens_hsa052140.96907501
63Axon guidance_Homo sapiens_hsa043600.96503351
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95497154
65Retinol metabolism_Homo sapiens_hsa008300.95341341
66Platelet activation_Homo sapiens_hsa046110.94891365
67Alcoholism_Homo sapiens_hsa050340.91692788
68Oocyte meiosis_Homo sapiens_hsa041140.90877388
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90444131
70Melanogenesis_Homo sapiens_hsa049160.89665968
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87464253
72Measles_Homo sapiens_hsa051620.86113112
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85611841
74Graft-versus-host disease_Homo sapiens_hsa053320.85352480
75Dorso-ventral axis formation_Homo sapiens_hsa043200.85301756
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84990190
77Ether lipid metabolism_Homo sapiens_hsa005650.82842335
78Thyroid hormone synthesis_Homo sapiens_hsa049180.82829154
79Leishmaniasis_Homo sapiens_hsa051400.82550373
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81267345
81Glycerolipid metabolism_Homo sapiens_hsa005610.80969140
82Allograft rejection_Homo sapiens_hsa053300.80415178
83Autoimmune thyroid disease_Homo sapiens_hsa053200.80018218
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79358809
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.78833193
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77597424
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77583149
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.75821476
89Glucagon signaling pathway_Homo sapiens_hsa049220.75683123
90Ovarian steroidogenesis_Homo sapiens_hsa049130.75530444
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.74653815
92Renal cell carcinoma_Homo sapiens_hsa052110.73991326
93Chronic myeloid leukemia_Homo sapiens_hsa052200.73125456
94Fatty acid biosynthesis_Homo sapiens_hsa000610.71600643
95Influenza A_Homo sapiens_hsa051640.71383033
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.71260365
97MAPK signaling pathway_Homo sapiens_hsa040100.70479238
98Endometrial cancer_Homo sapiens_hsa052130.69371684
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.69351494
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67073070
101Ras signaling pathway_Homo sapiens_hsa040140.65645328
102Tuberculosis_Homo sapiens_hsa051520.64270066
103Fatty acid degradation_Homo sapiens_hsa000710.64222085
104Circadian rhythm_Homo sapiens_hsa047100.64116127
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.64111812
106Toxoplasmosis_Homo sapiens_hsa051450.63723034
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.63513428
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61408878
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61286734
110Hematopoietic cell lineage_Homo sapiens_hsa046400.61230229
111TNF signaling pathway_Homo sapiens_hsa046680.60820507
112Notch signaling pathway_Homo sapiens_hsa043300.60781477
113Chemical carcinogenesis_Homo sapiens_hsa052040.60156324
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60038543
115PPAR signaling pathway_Homo sapiens_hsa033200.59914979
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59698883
117Pancreatic cancer_Homo sapiens_hsa052120.59490256
118Cardiac muscle contraction_Homo sapiens_hsa042600.59047847
119AMPK signaling pathway_Homo sapiens_hsa041520.56980954
120Dilated cardiomyopathy_Homo sapiens_hsa054140.56011926
121Arachidonic acid metabolism_Homo sapiens_hsa005900.55531519
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.55252066
123Insulin signaling pathway_Homo sapiens_hsa049100.54348271
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53454165
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53173707
126Pancreatic secretion_Homo sapiens_hsa049720.52325135
127Chemokine signaling pathway_Homo sapiens_hsa040620.48078137
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47468115
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46447201
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45352557
131Bile secretion_Homo sapiens_hsa049760.44910460
132Prolactin signaling pathway_Homo sapiens_hsa049170.44562136
133VEGF signaling pathway_Homo sapiens_hsa043700.43109426
134Wnt signaling pathway_Homo sapiens_hsa043100.42631463
135Colorectal cancer_Homo sapiens_hsa052100.41449791
136Inositol phosphate metabolism_Homo sapiens_hsa005620.38752006
137Prion diseases_Homo sapiens_hsa050200.38507749
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37921875
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36953284
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.36683959
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34846116
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.33334423
143Rap1 signaling pathway_Homo sapiens_hsa040150.33260268
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32642214
145Tight junction_Homo sapiens_hsa045300.31514202
146Choline metabolism in cancer_Homo sapiens_hsa052310.29676579
147FoxO signaling pathway_Homo sapiens_hsa040680.29645449
148Type I diabetes mellitus_Homo sapiens_hsa049400.25846267
149Non-small cell lung cancer_Homo sapiens_hsa052230.24984328
150Endocytosis_Homo sapiens_hsa041440.24158841
151Hepatitis C_Homo sapiens_hsa051600.22184503
152Nitrogen metabolism_Homo sapiens_hsa009100.19571015
153mTOR signaling pathway_Homo sapiens_hsa041500.19175455
154Butanoate metabolism_Homo sapiens_hsa006500.18678917
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17291739
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16503441
157Alzheimers disease_Homo sapiens_hsa050100.16174079
158Phagosome_Homo sapiens_hsa041450.14859823

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